Join us for a free two-day LECO Separation Science Workshop on September 23–24, 2026, at the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/companies/219">C³AL Laboratory</a> at Cal State LA. Registration is free, and meals and refreshments will be provided throughout the workshop.&nbsp;<h4>Registration</h4><blockquote>👉<a target="_blank" rel="noopener noreferrer" href="https://forms.cloud.microsoft/pages/responsepage.aspx?id=iYeNbqIuykW7qZP4_jUEVbznDB40eK1PgjPzhHyb__9URTFTTFA5UEEzQ1A4MUtFV0o4TEJTNlZCOS4u&amp;route=shorturl">Register HERE</a>Space is limited, register today!<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_LECO_Separation_Science_Workshop_registration_332543a18e.jpg" alt="LECO: LECO Separation Science Workshop - QR code for registration" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_LECO_Separation_Science_Workshop_registration_332543a18e.jpg 156w," sizes="100vw" width="437" height="437"></blockquote><h4>Hand-on Experience with the LECO Complex Chemical Composition Analysis Lab C3AL</h4><ul><li>Work directly with LECO instruments in the C3AL Laboratory</li><li>Learn complete analytical workflows from sample to answer</li><li>Get expert guidance from LECO application scientists</li><li>Develop methods and solve real-world challenges</li><li>Collaborate, ask questions, and build your skills</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Cal_State_LA_The_LECO_Pegasus_BTX_system_in_Cal_State_LA_s_LECO_Complex_Chemical_Compositional_Analysis_Lab_enhances_research_and_student_training_in_advanced_chemical_analysis_cover_b739e727ca.jpg" alt="Cal State LA: The LECO Pegasus BTX system in Cal State LA’s LECO Complex Chemical Compositional Analysis Lab enhances research and student training in advanced chemical analysis" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Cal_State_LA_The_LECO_Pegasus_BTX_system_in_Cal_State_LA_s_LECO_Complex_Chemical_Compositional_Analysis_Lab_enhances_research_and_student_training_in_advanced_chemical_analysis_cover_b739e727ca.jpg 227w," sizes="100vw" width="1252" height="863">The first day will focus on the fundamentals and theory of comprehensive two-dimensional gas chromatography (GC×GC), with an emphasis on understanding how GC×GC can enhance your research, solve complex analytical challenges, and support your laboratory or company goals.&nbsp;The second day will be dedicated to hands-on activities, giving participants the opportunity to work directly with LECO instrumentation, learn practical analytical workflows, and analyze their own samples with guidance from LECO application scientists.&nbsp;Whether you are new to GC×GC or looking to expand its use in your research or organization, this workshop offers a unique opportunity to learn, explore, and apply the technology in a practical setting. Space is limited, so register early!<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Cal_State_LA_LECO_QUADJET_G_Cx_GC_coupled_to_Pegasus_BT_4_D_TOM_MS_in_the_Complex_Chemical_Composition_Analysis_Lab_C_AL_077a14ae34/Cal-State-LA-LECO-QUADJET-GCxGC-coupled-to-Pegasus-BT-4D-TOM-MS-in-the-Complex-Chemical-Composition-Analysis-Lab-(CAL).jpg" alt="Cal State LA: LECO QUADJET GCxGC coupled to Pegasus BT 4D TOM MS in the Complex Chemical Composition Analysis Lab (C³AL)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Cal_State_LA_LECO_QUADJET_G_Cx_GC_coupled_to_Pegasus_BT_4_D_TOM_MS_in_the_Complex_Chemical_Composition_Analysis_Lab_C_AL_077a14ae34/thumbnail_Cal-State-LA-LECO-QUADJET-GCxGC-coupled-to-Pegasus-BT-4D-TOM-MS-in-the-Complex-Chemical-Composition-Analysis-Lab-(CAL).jpg 234w," sizes="100vw" width="1949" height="1299">

LECO Separation Science Workshop

This study presents a robust GC-MS method for direct detection and quantification of hydrogen in complex gas mixtures using electron ionization without dopants, reagent gases, or ion–molecule reactions. A modified EI source combined with a cryogenically cooled single capillary column achieved baseline separation of hydrogen from permanent gases and hydrocarbons in refinery gas while using helium as the carrier gas.The method demonstrated high sensitivity, linearity, and reproducibility across trace- and percent-level hydrogen concentrations. By simultaneously profiling other gas components in a single run, the approach simplifies conventional multi-column workflows and extends GC-MS capabilities for hydrogen analysis in complex industrial gas mixtures.<blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/ancham/article/98/26/19493/5200102/Hydrogen-Analysis-by-Gas-Chromatography-Mass#247324328">Hydrogen Analysis by Gas Chromatography–Mass Spectrometry&nbsp;</a></h4>Vladislav V. Lobodin* ; Yensil Park; Charles E. A. FinneyAnal. Chem. (2026) 98 (26): 19493–19499.<div><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acs.analchem.6c00257">https://doi.org/10.1021/acs.analchem.6c00257</a></div><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.<div><div><div><div>Hydrogen analysis in complex gas mixtures, including permanent gases, and volatile and semivolatile organic and inorganic compounds, is crucial for optimizing hydrogen production, storage and use, and ensuring reliability across diverse applications. Accurate hydrogen analysis underpins production and distribution processes such as steam methane reforming, gasification, and electrolysis, helping maintain purity and quality throughout the supply chain. (<a href="javascript:;">1</a>) Reliable hydrogen measurements are also critical for fuel cell power generation, where automotive manufacturers and fueling stations must meet strict fuel quality standards to ensure safety and performance. (<a href="javascript:;">2, 3</a>) Hydrogen is a flammable, colorless, and odorless gas that poses significant hazards in air at levels between 4 and 74%. (<a href="javascript:;">4, 5</a>)</div><div>Many industrial processes, including chemicals and petrochemicals, steel manufacturing, glass production, and electronics, depend on precise hydrogen measurements for process control, quality assurance, and energy efficiency. (<a href="javascript:;">6−9</a>) Beyond these established uses, hydrogen analysis plays a vital role in energy storage, power generation, and utilization as a fuel for transportation and grid applications (e.g., power-to-gas and sustainable integration), with monitoring required to maintain the integrity and safety of stored and injected hydrogen. (<a href="javascript:;">10, 11</a>) It is also essential for environmental monitoring, including leak detection, emissions control, (<a href="javascript:;">5, 12</a>) and geological exploration of natural hydrogen sources. (<a href="javascript:;">13−15</a>) In the aerospace industry, hydrogen analysis ensures its safe handling and optimal performance of hydrogen as a fuel or propellant. (<a href="javascript:;">16−18</a>) In addition, forensic studies also rely on hydrogen measurements to provide critical evidence in criminal investigations and legal cases. (<a href="javascript:;">19, 20</a>)</div><div>A GC coupled to thermal conductivity detector (TCD) continues to be a common method of choice for hydrogen analysis despite the detector limitations. (<a href="javascript:;">21, 22</a>) However, the use of helium as a carrier gas, despite being the most popular choice, results in complications with a TCD because the thermal conductivity for hydrogen and helium is very close and hydrogen produces a relatively low and nonlinear response. To avoid the hydrogen–helium interference, argon or nitrogen is used as the carrier gas with a TCD. However, the use of those gases compromises chromatographic resolution, significantly reduces sensitivity for the other compounds by a factor of ∼10, and can interfere with the detection of other analytes.</div><div>Besides a TCD, a helium ionization detector (HID) and an atomic emission detector (AED) are utilized by coupling to a GC to analyze hydrogen. (<a href="javascript:;">23, 24</a>) As in the case of a TCD, these detectors suffer from limitations and more importantly are not informative enough for identification of unknown chromatographic peaks during the hydrogen production development. Raman spectroscopy can detect low hydrogen concentrations but suffers from low sensitivity, complex setups, and long measurement times. Commercial systems have high detection limits and reduced precision over time, limiting practicality for dynamic or in-line applications. (<a href="javascript:;">25, 26</a>)</div><div>In contrast, GC coupled to MS serves as a powerful tool for both qualitative and quantitative analysis of various compound mixtures. (<a href="javascript:;">27</a>) Nonetheless, it has been reported that GC–MS faces challenges due to the difficulties of detecting lighter gases relative to the carrier gas (<a href="javascript:;">28, 29</a>) and direct EI in the absence of a dopant and ion–molecule reactions has been considered an impossible task. (<a href="javascript:;">29</a>)</div><div>Chromatographic analysis of hydrogen typically involved a dual-column setup to effectively separate it from other gases like O2, N2, CO, CO2, CH4, and various volatile hydrocarbons. These setups often used packed columns or molecular sieves PLOT columns, which additionally necessitated a particle trap on the detector side to block sorbent particles from entering the mass spectrometer’s ion source. (<a href="javascript:;">30, 31</a>)</div><div>In the present study, we report the development of a novel method for hydrogen analysis that employs direct EI of hydrogen and a simplified column configuration with a single capillary column. This approach is capable of detecting hydrogen across a broad concentration range, including trace levels in complex matrices. Importantly, our method also delivers compositional information for other gases in a single run, which can provide valuable context for many applications, thereby providing a significant advancement in hydrogen analysis methodology.<h4>Experimental Part</h4>The development of the method for hydrogen analysis was conducted with a GC–MS instrument employing an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7890B">Agilent 7890B GC</a> system and an Agilent <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=5977B">5977B mass spectrometer</a> (Agilent Technologies, Santa Clara, CA). The GC system was modified with a liquid N2 cryogenic valve kit (Agilent G3466A) to enable operation at low temperatures and liquid N2 (supplied from a Dewar) was used to cool the GC oven. Chromatography-grade helium with a purity of 99.9999% from Airgas (Radnor, PA) additionally passed through a helium purifier trap (model RMSH-2) from Agilent Technologies at a flow rate of 2.0 mL·min–1 was used as a carrier gas. The gas chromatograph inlet temperature was set to 200 °C. The GC oven temperature was programmed to hold at −80 °C for 2 min, subsequently ramped to 260 °C at 20 °C·min–1, and then held for 17 min. The transfer line was kept at 260 °C. A GS-GASPRO GC column (60 m long, 320 μm ID) from Agilent Technologies was used for chromatographic separation. The ion source was held at 230 °C. The EI ion source was modified by replacing a standard (350 G) magnet with a low-gauss magnet (220 G) assembly (Agilent part: G3163-60560). The hydrogen tune macros were procured from Diablo Analytical (Antioch, CA) and are described elsewhere. (<a href="javascript:;">32</a>) Both selected ion monitoring (SIM) and scan modes (recorded as a total ion chromatogram [TIC]) were utilized for detection of hydrogen and other gases. In particular, hydrogen detection was performed using SIM mode at a mass-to-charge ratio (m/z) of 2.<h4>Results and Discussion</h4><div>Here, we describe the development of a new hydrogen analysis approach that utilizes direct EI and selective detection at m/z = 2. Because the conventional EI source magnetic field is optimized to confine and focus electrons for ionization of species with m/z ≥ 10, this configuration is suboptimal for hydrogen, resulting in limited ionization efficiency and inefficient extraction of low-mass ions. The modification of the EI ion source with a low-gauss magnet is necessary to improve the formation and detection of H2+ ions. Reduction of the magnetic field strength decreases confinement of ionizing electrons emitted by the filament, thereby increasing the effective interaction volume and residence time of electrons with hydrogen molecules and enhancing ionization probability. In addition, the reduced magnetic field mitigates discrimination against low-mass ions during extraction and transmission into the mass analyzer. Collectively, these effects enhance sensitivity for H2 detection under EI conditions, eliminating the need for chemical ionization or indirect detection strategies.</div><div>In addition to the specialized hardware, custom low-mass optimization tune macros are required to achieve reliable sensitivity. We used tune macros from a hydrogen detection kit developed for Agilent MSD instruments that had been converted into standalone RGA-type mass analyzers. (<a href="javascript:;">32</a>) The tuning and mass-calibration procedure began with a low-mass autotune (lomass.u), followed by a helium optimization tune that used the helium carrier gas flowing through the column into the ion source as the tuning mixture. The optimization tune adjusts key ion–optics parameters, including repeller voltage, ion focus, electron energy, emission current, and entrance lens offset to maximize the response at m/z = 4. Additionally, ions at m/z = 69, 131, and 219 from the instrument’s calibration compound (PFTBA) were used to calibrate the mass axis, adjust the electron multiplier voltage, and set appropriate peak widths.<div>The mass spectrometry detection method involved simultaneous acquisition in SIM mode at m/z = 2 for hydrogen detection, and scan mode (at 2.4 scans s–1) within the range of m/z = 10–160 for other gases. Attempts to scan from m/z = 1.6 to 160 and subsequently extract the ion chromatogram at m/z = 2 resulted in a significantly lower signal response for hydrogen detection. Detection of hydrogen in SIM mode at m/z = 2 significantly improves the signal-to-noise (S/N) ratio and detection limit. The dwell time (the time during which the quadrupole is set at m/z = 2) was adjusted to 100 ms to enhance sensitivity. The high-resolution quadrupole settings (with peak width of 0.5 m/z) further improved S/N ratio by a factor of 2.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Anal_Chem_2026_98_26_19493_19499_Figure_1_GC_MS_analysis_of_hydrogen_standard_gas_mixtures_9439c835f2.jpg" alt="Anal. Chem. (2026) 98 (26): 19493–19499: Figure 1. GC–MS analysis of hydrogen standard gas mixtures. Upper figures show scans from m/z = 10–160, and lower figures show detection at m/z = 2. Left: 5% (50000 ppm) H2. Right: 5000 ppm of H2. Nitrogen is a balance gas." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Anal_Chem_2026_98_26_19493_19499_Figure_1_GC_MS_analysis_of_hydrogen_standard_gas_mixtures_9439c835f2.jpg 245w," sizes="100vw" width="1600" height="1022"></div><div>Standalone mass spectrometers (without GC) are often employed as RGAs, including for hydrogen detection. However, the absence of chromatographic separation limits reliable hydrogen quantification and comprehensive characterization of other species in a mixture. Furthermore, quadrupole mass spectrometers, commonly used both as RGAs and in GC–MS configurations, are subject to the “zero-blast” effect. (<a href="javascript:;">35</a>) This occurs when low DC voltage and RF amplitudes at low m/z are insufficient to prevent heavier ions from reaching the detector, leading to false signals in the low m/z range up to m/z = 4, even in the absence of corresponding low molecular weight analytes such as H2 or He. (<a href="javascript:;">36</a>) The “zero-blast” effect is particularly noticeable when measuring low levels of hydrogen amidst significantly higher concentrations of heavier gases, e.g., N2, O2, CO, Ar, CO2, H2O, hydrocarbons. This interference, which fluctuates constantly, makes the detection and resolution of hydrogen peaks at m/z = 2 highly challenging. <a href="javascript:;">Figure 1</a> shows the GC–MS analysis of two standard gas mixtures containing 50000 and 5000 ppm hydrogen with nitrogen as the balance gas. The injected sample volume was 250 μL, and the split ratio was 20:1. The upper plots display total ion chromatograms for the mass range m/z = 10–160, where the peak at 4.1 min corresponds to N2. The lower plots show extracted ion chromatograms at m/z = 2, where the peak at 3.4 min represents H2, while the peak at 4.1 min, matching the nitrogen elution time, is a false signal caused by the “zero-blast” effect. This interference is especially pronounced at lower hydrogen concentrations and would significantly affect quantitation in the absence of chromatographic resolution. By separating hydrogen into a distinct chromatographic peak with GC–MS, the “zero-blast” interference can be minimized. Therefore, efficient chromatographic separation of hydrogen from other gases is essential for reliable detection and quantification.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Anal_Chem_2026_98_26_19493_19499_Figure_4_GC_MS_analysis_of_refinery_gas_mixture_2977041c4b.jpg" alt="Anal. Chem. (2026) 98 (26): 19493–19499: Figure 4. GC–MS analysis of refinery gas mixture. Top. TIC for m/z = 10–160. Bottom. SIM at m/z = 2." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Anal_Chem_2026_98_26_19493_19499_Figure_4_GC_MS_analysis_of_refinery_gas_mixture_2977041c4b.jpg 226w," sizes="100vw" width="1600" height="1104"><a href="javascript:;">Figure 4</a> presents the gas chromatographic separation and mass spectrometric detection of a refinery gas test mixture using a combined scan (m/z = 10–160) and SIM (m/z = 2) acquisition mode. The total ion chromatogram (top panel) demonstrates excellent baseline separation of all major permanent gases and hydrocarbons, including O2, N2, CO, CH4, CO2, C2H4, C2H6, propane, propylene, n-butane, iso-butane, and various C5 isomers. Notably, even isobaric species such as N2, CO, and C2H4, each with nominal mass of 28 Da, are fully resolved chromatographically, enabling accurate identification and quantitation despite their identical molecular weights.The SIM trace at m/z = 2 (bottom panel) highlights the selective detection of hydrogen. One of the most critical regions for hydrogen separation is between 2 and 7 min, where H2 elutes well before O2, N2, CO, and CH4. This complete chromatographic resolution effectively eliminates interference from the quadrupole “zero-blast” effect and suppresses false low-mass signals that typically arise from high concentrations of heavier gases, thereby ensuring reliable and interference-free quantitation of hydrogen. The combination of efficient separation and SIM-based detection provides a robust analytical platform for accurate measurement of hydrogen in complex gas mixtures.</div></div><h4>Conclusions</h4>We successfully developed and validated a robust GC–MS method capable of directly detecting and quantifying hydrogen using EI without the need for dopants, reagent gases, or ion–molecule reaction schemes traditionally required for low-mass. By integrating specialized low-mass tuning procedures, a modified EI source, and a cryogenically cooled single-capillary column, we achieved efficient baseline chromatographic separation of hydrogen from other permanent gases, hydrocarbons, and isobaric species in complex gas mixtures. This separation was essential to eliminate false low-mass signals originating from the quadrupole “zero-blast” effect, and provided accurate, interference-free hydrogen quantitation. The method demonstrated high sensitivity and selectivity across more than 3 orders of magnitude concentration ranges from 5 to 5000 ppm, with excellent linearity (R2 = 0.9999). The combination of adjustable sample-loop volumes and tunable split ratios allowed optimization of peak shape and signal-to-noise performance for both trace-level and percent-level hydrogen concentrations. Triplicate analyses showed exceptional reproducibility, with variability below 1%, confirming suitability of the sampling approach for reliable quantitative analysis. Importantly, this approach provides simultaneous compositional information for a wide range of gases in a single analytical run, enabling comprehensive characterization of complex mixtures. This capability is particularly valuable for hydrogen production, storage, fuel-quality monitoring, geologic hydrogen exploration, industrial process control, safety and forensic applications, and environmental assessments where hydrogen must be measured alongside a panel of other gases.</div></div></div></div>

Hydrogen Analysis by Gas Chromatography–Mass Spectrometry

In the week of August 24, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Thermo Fisher Scientific: From legacy to leading edge: unlock more uptime, throughput, and confidence with modern GC-MS technology</h5><ul><li>Tu, 25.8.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6457">Registration</a></li></ul>Discover how upgrading legacy GC-MS systems to the Thermo Scientific ISQ 7610 GC-MS and TSQ 9610 GC-MS/MS can improve performance, simplify maintenance, and reduce operating costs.<h5>2. Waters Corporation: Foundations of a Sustainable, High-Performing QA Program</h5><ul><li>We, 26.8.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6448">Registration</a></li></ul>Build a sustainable, high-performing QA program in your lab. Learn the four pillars of data quality: method validation, analyst competency, control charting, and certified reference materials.

Webinars LabRulezGCMS Week 35/2026

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In 1936, the Laboratory Equipment Company introduced the first rapid carbon determinator for the American iron and steel industry.  Today, almost 80 years later, LECO is recognized globally as a leader in the development of high-quality analytical instrumentation, mass spectrometers, comprehensive two-dimensional chromatography, metallography & optical equipment as well as consumables.

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Shimadzu Corporation

PFAS &amp; Our Planet is a webinar series on PFAS testing in environmental samples, food and food contact materials, textiles and other materials. Alongside the laboratory and regulatory lens, the series addresses the broader planetary impact of PFAS, including their persistence and movement through water, soil, air, food systems, and materials. It brings together what laboratories and industry need to understand now: where PFAS rules are heading, which sample types are under increasing focus, what needs to be measured, and how those needs translate into method selection, workflow setup, and result reporting.<h4>Webinar Series Details</h4><ul><li>One registration to attend the full three-part series</li><li>Questions for experts in advance and/or live Q&amp;A</li><li>Access to recorded sessions provided</li></ul><h4>Who Should Attend:&nbsp;</h4>Environmental and water testing laboratories, food testing laboratories, food contact material and packaging laboratories, textile and materials testing laboratories, contract testing laboratories, public sector and regulatory laboratories, manufacturers of food, packaging, textiles, and consumer goods, quality, product safety, regulatory affairs, and sustainability functions, and research laboratories working on PFAS analysis.<h4>Recommended for:&nbsp;</h4>Analytical chemists, laboratory managers, QA/QC managers, regulatory affairs managers, food safety and product safety managers, environmental scientists, packaging and food contact materials specialists, textile and materials testing leads, sustainability and product stewardship managers, validation and method development scientists, and technical leaders in contract, public sector, and research laboratories.<h4>Regulatory context covered:&nbsp;</h4>EU and U.S. PFAS developments, food contact and packaging measures, environmental monitoring frameworks, OEKO-TEX requirements for textiles and materials, Singapore’s food and water surveillance activity, India’s draft PFAS-related packaging amendment, and emerging movement in parts of Southeast Asia like Thailand, Malaysia, Vietnam, Indonesia, Bangladesh and Philippines.<h3>Textiles and Materials</h3>Textiles and treated materials are facing stronger PFAS scrutiny as product restrictions widen and supply chains are asked to verify material content more clearly. This session will cover the main external reference points shaping that shift, including the EU REACH PFAS restriction process and OEKO-TEX requirements, which have become highly relevant for textile and material suppliers serving global brands.It will then step into the laboratory workflow for textiles and related materials, covering extraction and cleanup, targeted LC/MS/MS for non-volatile PFAS, selected GC/MS/MS approaches for volatile PFAS where relevant, contamination control, and reporting formats suited to product verification. Regional context will be framed around export-market pull, buyer specifications, and certification-driven testing, which are often the main drivers for suppliers in South and Southeast Asia.<blockquote>Presenter: David Saladin (Ecology Lab Team Leader, TESTEX AG, Swiss Textile Testing Institute)Presenter:&nbsp;Aimei Zou, Ph.D. (Application Scientist, Agilent Technologies, Singapore)</blockquote>

Agilent Technologies: PFAS & Our Planet: Textiles and Materials

PFAS & Our Planet: Textiles and Materials

PFAS in textiles webinar: regulations, LC-MS/MS and GC-MS/MS workflows, contamination control, and compliance for global supply chains.

<div>Reliable microplastics analysis requires both robust extraction workflows and defensible analytical techniques. In this two-part webinar, we bring together complementary approaches to address these challenges across the full analytical pipeline.The first session introduces a novel dry-ice-assisted fractionation method combined with the Agilent 8700 LDIR chemical imaging system, enabling efficient extraction and automated particle identification, sizing, and counting in complex soil and sediment samples. The second session focuses on pyrolysis–GC/MS, highlighting best practices to ensure accurate polymer identification while avoiding common pitfalls such as misidentification and background interference.Together, these approaches illustrate how combining orthogonal techniques, particle-based imaging and mass-based analysis, can strengthen data quality, improve reproducibility, and provide greater confidence in microplastics results. Attendees will gain practical insights into building robust, scalable workflows that support high-quality, defensible microplastics analysis across a range of environmental applications.<h4>Key Learning Objectives:</h4><ul><li>Build confidence in microplastics data through robust, defensible workflows</li><li>Improve data quality and reproducibility across complex sample types</li><li>Mitigate analytical risk by avoiding contamination and misidentification pitfalls</li><li>Combine complementary techniques to strengthen insight and validation</li><li>Enable scalable, routine analysis for real-world laboratory environments</li></ul><h4>Who Should Attend:</h4><ul><li>Microplastics researchers</li><li>Microplastics analysts from commercial, QA, or research labs seeking to understand key challenges in Microplastics analysis</li><li>Those interested in microplastics analysis and the development of standardized methodology around the world</li></ul><blockquote>Presenter: Subharthe Samandra (Australian Laboratory for Emerging Contaminants, School of Chemistry, The University of Melbourne, Australia)Presenter: Dr. Amy Cuthbertson (Application Engineer, Agilent Technologies Inc)Presenter: Melissa O’Meara (Forensic Science Consultant, ACS Media Group)</blockquote></div>

C&EN: Microplastics Analysis You Can Defend: From Method to Results

Microplastics Analysis You Can Defend: From Method to Results

Discover robust microplastics analysis. Learn how orthogonal LDIR imaging and Py-GC/MS workflows improve reproducibility and polymer identification

Advanced LDIR and Py-GC/MS for Microplastics Analysis

Gas chromatography (GC) challenges can arise at any stage of the analytical process, from method development and optimization to troubleshooting unexpected results and improving system performance.Join Diane Turner, FRSC, Director and Senior Consultant at Anthias Consulting (UK), for an interactive discussion covering GC troubleshooting, method development, and best practices. Drawing on more than 25 years of experience, Diane will share practical insights into optimizing key GC parameters, diagnosing common issues, and improving method reliability, efficiency, and data quality.<h4>By attending this presentation, you will:</h4><ul><li>Hear expert guidance supported by real-world examples shared during the session</li><li>Explore common GC issues and apply practical troubleshooting strategies to resolve them</li><li>Learn proven strategies for effective GC method development</li></ul>Help shape this presentation by posing a question to Diane.&nbsp;<h5>What you need to know:</h5><ul><li>Time: 9 am CDT (Chicago) / 10 am EDT (New York) / 3 pm BST (London/Lisbon) / 4 pm CEST (Paris/Berlin)</li><li>Duration: Approximately 60 minutes</li></ul><blockquote>Presenter: Diane Turner (Director and Senior Consultant, at Anthias Consulting Ltd)A Warwick University graduate, Diane completed her MSc in analytical chemistry and started her career in environmental then agrochemical science, later gaining experience as an applications chemist. Diane has developed methods and training within most industries globally for over 25 years. A Visiting Fellow at The Open University, she continues disease diagnosis research from her PhD, along with food, drug, and space applications. Diane is Past-President of the Royal Society of Chemistry (RSC) Analytical Sciences Community and Past-Chair of the Analytical Chemistry Trust Fund. Diane is a Trustee of the Recycling Organisation for Research Opportunities (RORO), amongst other committee memberships. Diane is co-author of 'Gas Chromatography-Mass Spectrometry: How Do I Get the Best Results?' and on the Editorial Board of the book series ‘Practical and Technical Guides for Lab-based Chemists’.</blockquote>

Separation Science: Expert Answers - GC Troubleshooting and Method Development

Expert Answers: GC Troubleshooting and Method Development

Join Diane Turner for an interactive GC troubleshooting webinar. Learn practical strategies for method development, optimization, and data quality.

GC Troubleshooting and Method Development Expert Answers

On the surface this would appear to be a simple separation; however, there are several challenges related to this analysis. We will discuss typical techniques utilized for resolving and detecting permanent gases including CO2 and Hydrogen. Other topics will include cryogenic techniques, column isolation, and the use of the “Select Permanent Gas column”.<blockquote>Speaker: Mark Sinnott&nbsp;Mark Sinnott works for Agilent Technologies as a Technical Support Engineer in the Consumables and Supplies Division (CSD). In his position at Agilent, Mark performs technical support and applications assistance to gas chromatographers worldwide. He has more than 22 years of experience in gas chromatography, including environmental analysis of compounds in air, soil and water matrices, including dissolved gas analysis for the electrical industry. Mark holds a Master’s Degree in Chemistry from California State University, Sacramento, and currently resides in Twin Falls Idaho.</blockquote>

Agilent Technologies: Becoming A Better Chromatographer Webinar Series

The Hidden Challenges of Permanent Gas Analysis and How to Solve Them

Master permanent gas analysis in GC. Explore solutions for separating CO2 and hydrogen, including cryogenic methods and column isolation techniques

Overcoming Challenges in Permanent Gas GC Analysis

In this SelectScience® TechTalk, Dr. Stefan Christian Gaugler, Professor of Applied Analytics at the Institute for Chemistry and Bioanalytics, University of Applied Sciences Northwestern Switzerland (FHNW), will provide an up-to-date overview of per- and polyfluoroalkyl substances (PFAS), focusing on their environmental impact, regulatory landscape, and associated analytical challenges. Highlighting the growing concern surrounding PFAS contamination across Europe, alongside the complexity arising from their chemical diversity and persistence.The session will explore current analytical workflows and sample preparation techniques, including the use of a novel PFAS-selective polymer for micro solid-phase extraction (µSPE), supporting efficient and automated analysis across diverse sample matrices. Attendees will gain insight into approaches for detecting both ultra-short and long-chain PFAS, as well as practical strategies to improve sensitivity, selectivity, and sustainability in PFAS analysis.<h4>What will this webinar cover?</h4><ul><li>The environmental relevance and regulatory developments surrounding PFAS in Europe.</li><li>The analytical challenges associated with PFAS diversity, including ultra-short and long-chain compounds.</li><li>Modern analytical workflows for PFAS detection using LC-MS/MS and GC-MS/MS techniques.</li><li>The advantages of novel PFAS-selective polymer-based µSPE methods for efficient and automated sample preparation.</li></ul><blockquote>Speaker: Prof. Dr. Stefan Christian Gaugler (Professor of Applied Analytics at the Institute for Chemistry and Bioanalytics, University of Applied Sciences Northwestern Switzerland (FHNW))Prof. Dr. Stefan Christian Gaugler is a researcher and lecturer at FHNW with a background in life sciences and analytical chemistry, driven by a long-standing interest in translating complex biomarker diagnostics into accessible solutions. Over the past 14 years, his work has focused on microsampling technologies, particularly dried blood spot (DBS) analysis.He currently leads the micro lab at FHNW, where the team operates one of the world’s most technologically advanced dried blood spot laboratories and develops advanced methods for trace analysis of emerging contaminants. Alongside his research, he teaches advanced analytical techniques and laboratory automation, with a strong focus on bridging academia and real-world application.His current work, including this presentation, focuses on advancing PFAS analysis to better understand and address their impact on human health and the environment.</blockquote><blockquote>Moderator: Cameron Smith-Craig (Pharma and Applied Sciences Editor, SelectScience)</blockquote>

SelectScience: Advancing PFAS analytics across complex matrices

Advancing PFAS analytics across complex matrices

Discover automated µSPE solutions for PFAS analysis. Learn strategies from FHNW experts to overcome matrix challenges for ultra-short & long chains.

Advancing PFAS Analytics Across Complex Matrices via µSPE

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h4>Something new is on the horizon for isotopic analysis</h4>Over the past several years, Orbitrap-based isotope ratio analysis has evolved into a powerful approach for investigating isotopic composition with molecular-level detail, opening new possibilities across environmental and geochemical studies, metabolism research, food authenticity, and beyond.Now we're taking the next step.Join us for a first look at the next generation of Thermo Scientific Orbitrap IRMS.Discover how new Orbitrap IRMS is streamlining the complete isotope analysis workflow—from method development and data acquisition to calibration, data processing, and reporting.You'll hear from Thermo Fisher Scientific application specialists and Prof. Douglas Morrison (SUERC), who will share practical experience and insights gained from applying the technology across environmental and bioscience research.<h5>During the webinar, you'll see how to:</h5><ul><li>Configure isotope methods with new, dedicated workflow tools</li><li>Acquire high-quality isotope data using automated sample/reference strategies</li><li>Process and calibrate isotope ratios in an integrated software environment</li><li>Generate confident isotopic insights from samples</li></ul><blockquote>Presenter: Dr. Sukanya Sengupta (Application Specialist, Thermo Fisher Scientific)Sukanya is a geochemist with PhD and postdoctoral research experience, from University of Göttingen, in isotope ratio mass spectrometry (IRMS) and triple oxygen isotope ratios of terrestrial samples. Since joining Thermo Fisher Scientific in Bremen in 2020, she has supported ICP-OES, ICP-MS, and IRMS customers with method and application development for routine and research analytical workflows.Presenter:&nbsp;Dr. Brett Davidheiser (Field Application Scientist, Thermo Fisher Scientific)Brett has a wide experience in isotope ratio mass spectrometry from his PhD at the University of Glasgow, running a stable isotope lab at CU Boulder, to his work at Thermo Fisher Scientific as applications scientist. He is currently involved in helping new users come up to speed with Thermo Scientific Orbitrap IRMS technology for natural abundance isotope ratio analysis.Presenter:&nbsp;Prof. Douglas J. Morrison (Professor of Isotope Bioscience, SUERC – Centre for the Isotope Sciences, University of Glasgow)With a PhD from the University of Strathclyde, using stable isotopes to investigate human physiology, Douglas has a strong track record of using stable isotopes in the biosciences and currently leads the Stable Isotope Biochemistry Laboratory at SUERC. Using classical compound-specific isotope analyses, and more recently Orbitrap isotope ratio mass spectrometry, underpins his research into molecular mechanisms driving health and disease in humans with a major focus on the gut and gut microbiome.</blockquote></div></div></div>

Thermo Fisher Scientific: Powerful isotopic insights, elevated

Powerful isotopic insights, elevated

Join us for a first look at the next generation of Thermo Scientific Orbitrap IRMS.

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Accelerating the adoption of renewable fuels is central to the global energy transition, but analyzing complex matrices like Sustainable Aviation Fuel (SAF) and biodiesel can pose new challenges.In this latest session on Shimadzu’s Digital Classrooms, discover practical strategies into navigating these shifts with Shimadzu's latest innovations. Get insights into how to streamline fuel characterization, ensure strict quality control, and maintain asset reliability using the new Nexis GC-2060, Transformer Oil Gas Analysis (TOGAS) systems, dedicated System GC solutions, GC-SCD sulfur analysis, and LC-based technologies.We will also demonstrate how to expand your laboratory's R&amp;D capabilities using Plasmion SICRIT® technology for direct GC-LCMS coupling—giving you the advanced insights needed to optimize both conventional petrochemicals and next-generation renewable fuels. Register Now!<h4>Learning Objectives</h4><ul><li>Explore applications of Transformer Oil Gas Analysis (TOGAS) for transformer condition monitoring and energy infrastructure reliability</li><li>Discover Shimadzu's latest Nexis GC-2060 and System GC solutions for energy, refinery, petrochemical, and fuel testing laboratories</li><li>Applications of GC, LC, and GC-SCD technologies in HPI, SAF, and biodiesel analysis</li><li>Understand how SICRIT® technology enables direct GC coupling to LC-MS systems for advanced fuel and petrochemical research</li></ul><blockquote>Presenter: Peter, Puah Perng Yang (Market Specialist Chemical, Shimadzu Asia Pacific)Presenter:&nbsp;Elvi Horiyanto (Product Specialist, GC, Shimadzu Asia Pacific)Presenter:&nbsp;Dr. Jan Bucek (Head of Global Sales, Plasmion GmbH)</blockquote></div></div></div>

Shimadzu: Powering Energy Security and the Energy Transition: Advanced Analytical Solutions for Petroleum and Renewable Fuels

Powering Energy Security and the Energy Transition: Advanced Analytical Solutions for Petroleum and Renewable Fuels

Shimadzu webinar on SAF, biodiesel and petrochemical analysis using GC, LC, GC-SCD, TOGAS and SICRIT GC-LCMS coupling.

Analytical Solutions for Petroleum and Renewable Fuels

This webinar introduces the fundamental components of a gas chromatograph and explains the role of columns and stationary phase selectivity in compound separation. Different injection techniques, compound types, and factors influencing chromatographic performance will be discussed. In addition, the webinar covers the theoretical background of method optimization and efficient GC separation.<h4>Key Learnings:</h4><ul><li>Understanding GC fundamentals improves method development and troubleshooting.</li><li>Stationary phase selectivity and injection technique strongly influence separation performance.</li><li>Optimization strategies help achieve more efficient and reliable GC separations</li></ul>

Basics. Principles of GC

This webinar introduces the fundamental components of a gas chromatograph and explains the role of columns and stationary phase selectivity.

The Indian pharmaceutical industry is constantly seeking faster, more efficient ways to ensure product quality while reducing testing time and operational costs. Traditional methods such as HPLC are highly effective but can be time-consuming and require extensive sample preparation.Join this webinar to discover how the Agilent TRS100 Quantitative Pharmaceutical Analysis System uses Transmission Raman Spectroscopy to provide rapid, non-destructive analysis of intact tablets and capsules. Learn how TRS100 enables fast content uniformity testing, assay, identification, and solid-state analysis with minimal sample handling, helping laboratories improve throughput and accelerate decision-making.<h4>Why Attend?</h4><ul><li>Learn how to perform rapid content uniformity testing on intact tablets and capsules.</li><li>Reduce analysis time and eliminate sample preparation.</li><li>Increase laboratory productivity while reducing solvent and consumable use.</li><li>Explore applications in assay, identification, polymorph, and crystallinity analysis.</li><li>Understand how TRS complements existing HPLC workflows in pharmaceutical QC.</li></ul><h4>Who Should Attend?</h4><ul><li>QC and QA Managers</li><li>Analytical and Pharmaceutical Scientists</li><li>Formulation and R&amp;D Scientists</li><li>Manufacturing and Process Development Teams</li><li>Regulatory and Compliance Professionals</li></ul><h4>What You Will Learn</h4><ul><li>Fundamentals of Transmission Raman Spectroscopy</li><li>How the Agilent TRS100 performs whole-tablet analysis</li><li>Applications in content uniformity and solid-state characterization</li><li>Benefits of implementing rapid, non-destructive testing in pharmaceutical laboratories</li></ul>Join us to see how the Agilent TRS100 is helping pharmaceutical laboratories in India accelerate quality control while maintaining confidence in analytical results.<blockquote>Speaker: Sounik Saha (Dr., Dr. Reddy’s Laboratories, India)Dr. Sounik Saha, PhD, is a Material Science Expert and analytical R&amp;D leader at Dr. Reddy’s Laboratories, India with extensive experience in advanced material characterization.He completed his PhD from the Indian Institute of Science, Bangalore in 2011, followed by postdoctoral research at internationally renowned institutions including UT Southwestern Medical Center, Dallas, USA, and Mayo Clinic, Rochester, USA. He joined Dr. Reddy’s Laboratories in 2015 as part of the Advanced Characterization Technology Laboratory, where he has contributed significantly to strengthening advanced analytical capabilities for complex pharmaceutical product development. He led the Analytical Material Sciences Team at Novartis, India from 2021 to 2025 before joining back at Dr. Reddy’s Laboratories.Dr. Saha specializes in state-of-the-art spectroscopic and microscopic characterization techniques and plays a key role in designing robust analytical strategies for complex generic product development. He has been instrumental in implementing Near-Infrared Spectroscopy and Transmission Raman Spectroscopy-based PAT initiatives across R&amp;D and manufacturing at Dr. Reddy’s Laboratories, contributing to successful regulatory filings and approvals for multiple high-value oral solid dosage products.His work effectively bridges advanced materials science, analytical innovation, regulatory expectations, and practical product development outcomes.Title of talk “Non-Destructive Analytical Technologies as Alternatives to Conventional approaches: Regulatory Expectations and Practical Insights”</blockquote><blockquote>Speaker: Ms. Vijaya Jyothi (Product Specialist - Spectroscopy, Agilent Technologies India Pvt. Ltd.)Vijaya Jyothi is a seasoned product specialist at Agilent Technologies. She manages the spectroscopy division, having extensive expertise in spectroscopy applications across diverse industries, offering deep insights and solutions tailored to varied analytical needs.</blockquote>

Agilent Technologies: Fast, Non-Destructive Pharmaceutical Analysis with the Agilent TRS100

Fast, Non-Destructive Pharmaceutical Analysis with the Agilent TRS100

Optimize pharmaceutical QC with the Agilent TRS100. Replace tedious sample prep with rapid, non-destructive analysis of whole tablets and capsules

Rapid Non-Destructive Pharma Analysis: Agilent TRS100

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>As laboratories grow, managing data across multiple instruments, users, and locations becomes increasingly complex. If you are looking to improve efficiency, strengthen data integrity, simplify administration, and support regulatory compliance through centralized data management and standardized workflows, you need to join this webinar.Are you currently using software on individual workstations? Do you have multiple software packages to run different vendor instruments? Discover how deploying Thermo Scientific™ Chromeleon™ software can help you. This session will explore how transitioning to a networked deployment can deliver greater scalability, enhanced collaboration, streamlined management, and a foundation for future digital transformation. Attendees will gain practical insights into the business and operational benefits of Chromeleon software across a wide range of industries.<h4>Who should attend?</h4><ul><li>Current Chromeleon workstation users&nbsp;</li><li>Those running multiple software packages looking to reduce training efforts</li><li>Laboratory managers and supervisors</li><li>Chromatography and analytical scientists</li><li>Laboratory IT and informatics professionals</li><li>Quality assurance and compliance personnel</li><li>Organizations looking to improve operational efficiency, data management, and scalability across their laboratories</li></ul><blockquote>Presenter: Kimy Young (Senior Manager, Software Product Specialists, Thermo Fisher Scientific)Kimy Young is the Senior Manager of software product specialists at Thermo Fisher Scientific. She has been with Thermo Fisher since November 2015. Her background includes administration of Chromeleon CDS, laboratory information management systems (LIMS), Quality Assurance (QA), and IT projects.Presenter: Juan Carmona (Chromeleon CDS Specialist, Thermo Fisher Scientific)Juan Carmona is a Chromeleon Specialist at Thermo Fisher Scientific based out of Pflugerville, TX. He has been with Thermo Fisher Scientific for over 15 years. At Thermo Fisher Scientific, he is currently focusing on expanding the customer base using Chromeleon CDS for small networks and enterprise deployments. Prior to joining this group, he was part of the GC/GCMS Center of Excellence team providing support for the product line.</blockquote></div></div></div>

Thermo Fisher Scientific: Chromeleon software webinar series

Drive lab collaboration and efficiency with a networked chromatography and mass spectrometry data system

Discover how Chromeleon CDS network deployment improves data management, compliance, scalability, and workflow efficiency across analytical laboratories.