Broadband Laser-Based Infrared Detector for Gas Chromatography

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 30th September 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring to you applications by Agilent Technologies, Waters Corporation, and Thermo Fisher Scientific, and a poster from <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/companies/296">ASMS</a> by Shimadzu!<h4>1. Shimadzu: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/TP_093_Analysis_of_PFAS_in_Water_Final_05292024_8fa9fcb27d.pdf">Analysis of Volatile PFAS in Water Using Head-Space Solid Phase Microextraction- Gas Chromatography/Mass Spectrometry (HS-SPME GC/MS)</a></h4><ul><li>Poster / <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/companies/296">ASMS</a>&nbsp;</li></ul>Introduction&nbsp;Per- and Polyfluoroalkyl Substances (PFAS) are environmental pollutants with recognized health and environmental concerns due to their probable toxicity, persistence, and ubiquitousness throughout the environment, and consumer and industrial products. PFAS encompass a large family of chemicals with varying physicochemical properties. These properties not only affect their toxicity and environmental fate, but also complicates chemical analysis.In this work, a Head-Space Solid Phase Microextraction-Gas Chromatography/Mass Spectrometry (HS-SPME GCMS) analytical method was developed to analyze six classes of volatile PFAS in water. This HS-SPME method presents the advantage of simplifying sample extraction and handling for the analysis of volatile PFAS in water, hence, minimizing operational costs, potential errors, and risk of sample-cross contamination.ConclusionThis study demonstrated the use of a Shimadzu GC/MS-QP2020 NX single quadrupole instrument configured with the AOC-6000 Plus multifunctional autosampler and an automated head space solid phase microextraction unit for measurement of volatile PFAS compounds in water. Linear calibration curves were obtained for all compounds (R 2 ≥ 0.993 and RF %RSD &lt; 20 %). The HS-SPME GC/MS-QP2020 NX method demonstrated qualitative and quantitative capability of analyzing PFAS compounds.<h4>2. Thermo Fisher Scientific: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_003028_gc_ms_isq_epa_vocs_an003028_na_en_7646797ef5.pdf">Analysis of volatile organic compounds in drinking water according to U.S. EPA Method 524.4</a></h4><ul><li>Application</li></ul>GoalDemonstration of an analytical method that meets the requirements outlined in U.S. EPA Method 524.4 for the quantitation of volatile organic compounds (VOCs) in drinking water, using the Teledyne LABS Tekmar Lumin Purge and Trap (P&amp;T) concentrator paired with the AQUATek LVA autosampler system along with a Thermo Scientific™ ISQ™ 7610 MS system coupled with a Thermo Scientific™ TRACE™ 1610 gas chromatograph (GC) and Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS). Target analyte linearity, method detection limit (MDL), minimum report level (MRL), and mid-point precision and accuracy were assessed to evaluate method performance.Keywords: EPA, U.S. EPA 524.4, VOCs, phthalates, trace analysis, gas chromatography, single quadrupole mass spectrometry, selected ion monitoring, sensitivity, GRO, THM, volatiles, environmental lab, environmental sample analysis, analytical testing laboratories, ISQ 7610 MS, TRACE 1610 GC, GC-MS.IntroductionVolatile organic compounds (VOCs) are man-made contaminants in various products that pose environmental and public health risks. These compounds are regulated in drinking water, and laboratories follow regulations including U.S. EPA Method 524.2.1 A previous application note described U.S. EPA Method 524.2,2,3 which is the most common method for VOC water testing in the USA. U.S. EPA Method 524.4 is an updated method that allows for nitrogen to be used as the purge gas, thus reducing helium consumption, and is now being more widely used. Targeting 75 VOCs, this method differs by offering more method parameter flexibility but stricter quality control, including the stringent calculation of the minimum reporting level for evaluating calibration checks.Implementing U.S. EPA Method 524.4 can present multiple challenges for laboratories. Striking a balance between optimized method conditions and meeting the acceptance criteria, like detection limit requirements for various compound concentrations, is pivotal. Another major hurdle is managing the water matrix to minimize GC-MS system water introduction, which could lead to detrimental effects and delay sample reporting, thereby increasing public safety risks. Ultimately, maintaining consistency in test results to avoid sample reanalysis is crucial. Another factor for laboratories to consider is the fluctuating cost of helium, which is the analytical gas of choice for this analysis. Reducing the use of helium—a limited resource—will enable the laboratory to reduce operational costs and increase profitability.The following evaluation describes the use of the ISQ 7610 GC-MS system coupled with a TRACE 1610 GC with the Thermo Scientific™ HeSaver-H2Safer™ split/splitless injector and Teledyne LABS Tekmar Lumin P&amp;T concentrator paired with the AQUATek LVA autosampler for U.S. EPA Method 524.4.ConclusionThe combined solution of the TRACE 1610 GC coupled with the ISQ 7610 system and the Tekmar Lumin P&amp;T concentrator with the AQUATek LVA autosampler system successfully addresses the challenges of VOC analysis and provides a robust, sensitive solution needed for ensuring maximized sample throughput and regulatory method compliance for U.S. EPA Method 524.4.<ul><li>Excellent linearity for all compounds was demonstrated with the linear regression (r²≥0.995) of the calibration response factors passing all method requirements.</li><li>MDL and precision for seven 0.5 ppb standards showed no interference from excessive water and produced very reproducible results.</li><li>The precision for n=30 samples over 245 injections displayed &lt;30% RSD for all compounds as the method requires and an average recovery of 91%.</li><li>Utilizing HeSaver-H2Safer technology reduced helium consumption for the method by 4 times, which provides a significant cost savings.</li></ul><h4>3. Waters Corporation: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720008298_en_db4158391c.pdf">Extractables Analysis of Nasal Spray Devices Using Gas Chromatography and High- Resolution Mass Spectrometry With Soft Ionization</a></h4><ul><li>Application</li></ul>AbstractDue to concern about the safety of components from plastic, it is crucial to screen for and identify potential extractables and leachables (E&amp;L) in pharmaceutical packaging and medical devices. For volatile, and semi-volatile compounds, gas chromatography-mass spectrometry (GC-MS) with electron ionization (EI) is typically used. Compounds are determined using scientific libraries; however, where compounds are not listed or where the sensitivity of EI-MS is not sufficient, the identification process becomes challenging.Here, we describe an E&amp;L screening experiment using gas chromatography and a quadrupole time of flight high-resolution mass spectrometer (QToF-HRMS) with atmospheric pressure gas chromatography (APGC) for soft ionization. A data independent acquisition (DIA) strategy is utilized to aid screening and elucidation which are combined in a screening software solution.Benefits<ul><li>GC-QToF MS with APGC as an orthogonal technique to LC-QToF-MS allows for comprehensive compound coverage with increased sensitivity compared to typical EI techniques</li><li>The UNIFI™ application within the waters_connect™ platform provides customized workflows to simplify screening and structural elucidation in complex datasets</li><li>The Xevo™ G3 QTof Mass Spectrometer enables confident identification of E&amp;L components in complex matrices through novel ion optics and detection system which maximize transmission</li><li>Soft ionization using the APGC™ source allows for the detection of molecular ions from which elemental compositions can be derived to aid compound identification and confirmation&nbsp;</li><li>MSE, a data independent acquisition, increases confidence in identifications when screening against a library and provides additional information to aid structural elucidation</li></ul>Conclusion&nbsp;When undertaking E&amp;L screening analyses it is important to use a range of analytical techniques to account for different compound chemistries. GC-QToF MS with APGC as an orthogonal technique to LC-QToF-MS allowed for comprehensive compound coverage with increased sensitivity compared to typical EI techniques. Due to the soft ionization of APGC, the intact molecular ion is often present in the spectra. This combined with a data independent acquisition, MSE mode, utilizes full spectral acquisition of the accurate mass information of both precursor and fragment ions.This approach boosts confidence in component identifications when screening against an MS/MS library, while minimizing false positives. For instance, in the LC-QToF-MS there were just under 40 potential compounds matches in sample E48 after considering factors such as retention time match, mass accuracy below 3 ppm, and the presence of at least one fragment ion. A further 38 compound matches in sample E48 were tentatively identified using GC-QToF MS with APGC, with mass accuracy below 3 ppm, and the presence of at least one fragment ion.MSE data also aids in the structural elucidation of unknown substances by utilizing accurate mass and corresponding fragment ions, facilitating comprehensive characterization. This data increases confidence in identifications of components and assists with structural elucidation of unknowns to ultimately aid full characterization. For example an unknown with protonated m/z 284.2703 was tentatively identified as a N-(2-(1-piperazinyl)ethyl)decanamide (mass error 2.33 ppm) by the software.For the extractables analysis of nasal sprays the UNIFI application within the waters_connect platform provided SST benchmarking, screening against a library, summary plots to identify trends, filtering of AET levels, binary compare mode to isolate relevant unknowns, and a Discovery Tool for elucidation of unknowns.<h4>4. Agilent Technologies: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_voc_rubber_gasket_extracts_gc_msd_5994_7777en_agilent_6a0a6bf7d0.pdf">Analysis of Volatile Compounds Identified in Rubber Gasket Extracts Using GC/MSD and High-Resolution GC/Q-TOF</a></h4><ul><li>Application</li></ul>AbstractChemicals that are part of polymeric container closure systems (CCS) and drug delivery systems have the potential to migrate into drug products during manufacturing, storage, transport, and delivery, and must be identified in the final products to ensure their safety.This application note presents a rubber gasket extractables study using a unit mass resolution gas chromatography/mass selective detector (GC/MSD) and a high-resolution gas chromatography/quadrupole time-of-flight (GC/Q-TOF) mass spectrometer to establish a process for identifying GC-amenable extractables and leachable (E&amp;L) compounds.IntroductionElastomeric gaskets, plungers, and O-rings are common sources of leachable compounds in the manufacturing, storage, and delivery of drug products. E&amp;Ls derived from elastomeric components may impact the stability and efficacy of small and large molecule drug products1, and therefore need to be characterized thoroughly. Exposure to some E&amp;L chemicals, such as phthalates and nitrosamines, even at low levels, may cause safety concerns.2 Chemicals derived from the elastomer manufacturing process typically include accelerators, activators, antioxidants, fillers, plasticizers (including phthalates), mold release agents, and other additives3 that may leach into the final product. Some additives present in elastomer packaging materials may also contain polycyclic aromatic hydrocarbons (PAHs)4 and aliphatic hydrocarbons.GC/MS is a commonly used technique for analyzing volatile and semivolatile organic compounds in the E&amp;L space. This study demonstrates the capabilities of GC/MSD to identify GC-amenable compounds present in a solvent extract of a rubber gasket by leveraging chromatographic deconvolution in combination with retention index (RI)-based filtering. Adding a high-resolution accurate mass GC/Q-TOF into the E&amp;L workflow provided a higher number of identified chemicals. It also increased confidence in compound identification and enabled structure elucidation of unknown compounds.The study was performed in the Network Workstation configuration using Agilent OpenLab Electronic Content Management (ECM) XT as the data repository. This configuration enabled tools that facilitate compliance with various national and EU electronic record regulations, including audit trails, user authentication, role-based permission controls, and remote data storage.5ConclusionThe GC/MSD is an effective and accessible tool for the analysis of volatile and semivolatile compounds in complex E&amp;L extracts. The established workflow includes deconvolution and an RI-based library search with the data acquisition performed in a compliant environment.The high-resolution Agilent 7250 GC/Q-TOF enabled the identification of additional components with increased confidence, as well as structure elucidation of the unknown compounds.Furthermore, using the novel ultra-low bleed Agilent J&amp;W DB-5Q GC column resulted in a significant decrease in background, which helps in the identification of late-eluting compounds.

News from LabRulezGCMS Library - Week 40, 2024

NIST, Wiley, and user-created EI mass spectral libraries are very powerful tools for the identification of organic compounds in complex mixtures by gas chromatography-mass spectrometry (GC-MS). &nbsp;This series of webinars will demonstrate the use of the NIST software suite including the NIST Search, AMDIS, and MS Interpreter for searching EI libraries. The series should be useful to a wide variety of research and developmental scientists involved in medical, environmental, industrial, forensic, and biological disciplines.<blockquote>The webinars demonstrate both Versions 3.0 (2023) and V2.4 of the NIST search. If you are using V3.0, start with Part 0. If you are using V2.4, start with Part I.</blockquote><h5>Today, we will look at:</h5><h3>Part V: Creating and Sharing User EI and MS/MS Libraries</h3><ul><li>Help Files for NIST Search</li><li>General Windows commands/functions</li><li>Creating a user library spectrum</li><li>Creating a user library spectrum: opening edit spectrum</li><li>Creating a user library spectrum: spectrum information window</li><li>Creating a user library spectrum: adding comments and synonyms</li><li>Creating a user library spectrum: using windows notepad and tags</li><li>Creating a user library spectrum: comment field display with user tags</li><li>Creating a user library spectrum: comment field display showing user tags</li><li>Tags included with Wiley libraries</li><li>Possible quality checks before adding spectra to user libraries</li><li>Addition of spectrum to user library or creating new library</li><li>(Re)Index Indices for structure, hybrid search and InChIKey for user library</li><li>NIST formatted user libraries at Eastman Chemical Company</li><li>Software essentials and approach</li><li>Excerpt of typical DOS script used in approach</li><li>Webinar References</li><li>Acknowledgements</li></ul><blockquote>Detailed Handouts including tables of content are available in the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ei_user_libraries_pt_v_2_cc2179c747/ei_user_libraries_pt_v-2.pdf">LabRulezGCMS library</a></blockquote><h4>Other parts of this series are focused on:</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=KppCCeYTWTU">Part 0: Changes in EI NIST23 Program (V3.0)</a> (video only)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/article/4438">Part I: Spectral Searches with NIST MS Search</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/article/4463">Part II: Structure Searches with MS Search and Using MS Interpreter</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/article/4494">Part III: AMDIS (NIST) for Processing EI Mass Spectral Data Files</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/article/4528">Part IV: Advanced NIST Hybrid Search of EI and MS/MS Spectra</a></li><li>Part V: Creating and Sharing User EI and MS/MS Libraries (this part)</li><li>Part VI: Creating and Using Retention Indices in NIST Software</li><li>Part VII: &nbsp;Tracking Complex Coelution with AMDIS and NIST Search</li></ul><h4>Higher quality videos can be downloaded here:</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1XGOnO6vwyJv6rPucIH-NgOTBdvH1jNDg/view?usp=sharing">Higher Quality Video Part 0</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/116Gzyh9nT4iDfJkac20K9aYarGvxpV2e/view?usp=sharing">Higher Quality Videos Pt. I-V Zipped</a></li></ul><h4>Other Webinar Resources:</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1EGlEubUOWiNy3Y3mQZWdoaUXsFKTNjjj/view?usp=sharing">Test Files Used In Part VII for Tracking Coelution in Complex Mixtures with AMDIS and NIST</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2023/04/27/nist2023-library-and-software-available-in-early-june/">New NIST23 Brochures and Purchasing</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2023/07/nist_2023_release_presentation.pdf">NIST23 ASMS Presentation Houston, TX</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://blog.sepscience.com/massspectrometry/nist-23">NIST 23 Separation Science Article by David Sparkman</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/08/20/most-current-user-manuals-for-nist-search-and-amdis/">NIST and AMDIS User Manuals</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/08/20/most-current-user-manuals-for-nist-search-and-amdis/">NIST Approach for Creating Libraries</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/08/20/most-current-user-manuals-for-nist-search-and-amdis/">Databases Listed in Version 3.0 (2023)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.acdlabs.com/resources/free-chemistry-software-apps/chemsketch-freeware/">ACD Free Software</a> (structure drawing program personal/academic use)</li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2023/04/free-drawing-program-mass-spec-calculator-professional/">Mass Spec Calculator Professional</a> (free structure drawing program)</li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2011/08/28/using-nist-search-program-with-data-processing-and-drawing-programs/">Using with Manufacturers Data Processing Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/10/11/excel-deltamass-table-for-hybrid-searches/">Delta Mass Table (Excel Format)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2023/05/deltamass_ei.pdf">Delta Mass Table (PDF format)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2023/01/25/unknown-identification-presentation-at-current-trends-in-seized-drugs-analysis-symposium/">Hybrid Search/ChemSpider/SciFinder for Illicit Drug Identifications</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2011/08/28/using-nist-search-program-with-data-processing-and-drawing-programs/">Importing Mass Spectra to NIST Search Program</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2021/01/31/nist-ms-interpreter/">MS_Interpreter Correlating Structure to Spectrum</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/09/21/nists-suggested-settings-for-amdis-filter-settings/">NIST Tutorials and Settings for AMDIS</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/09/20/using-example-file-and-spectra/">Example Files for Part III AMDIS Webinar</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/09/20/using-example-file-and-spectra/">Example Spectra/Structures in Library Format Parts I-V</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2020/09/wiley_usermanual.pdf">Wiley Library User Manual with Spectral Source Codes</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2011/08/28/using-nist-search-program-with-data-processing-and-drawing-programs/">Using with Manufacturers Data Processing Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2020/12/observations-on-spectra-in-mona-database.pdf">Components in Free MONA Libraries</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1kGdFVnYYmrE-n1trB6ngVRPrSgyHsEx7/view?usp=share_link">MONA Library in EI format</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1os21j4L87oUmQ8GhQcIvX4edk6014JJ5/view?usp=drive_link">MONA and Other Free Libraries, 60,829 EI Spectra</a> (see read_me in zip file)</li></ul>

Effective Use of EI Mass Spectral Databases in Unknown Identifications - Part V: Creating and Sharing User EI and MS/MS Libraries

Article

Application

Poster

Scientific article

Video

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

James Little/Mass Spec Interpretation Services

Separation Science

Agilent Technologies

Phenomenex

Restek Corporation

The installation and care of your GC column is of the utmost importance. Whether you are new to the practice of gas chromatography, or would like a refresher, join us as we discuss proper column installation and handling for all Agilent GCs, including the Agilent Intuvo 9000 GC. We will also address the common modes of column degradation and some of the misconceptions that people have concerning column degradation. Lastly, we will discuss ways that you can protect and maintain your column performance and extend its lifetime while minimizing instrument downtime.
<blockquote>
Presenter: Alex Ucci (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
In his current position at Agilent, Alex provides application assistance and technical support for sample preparation products as well as GC and LC consumables. Before he joined Agilent in 2014, Alex was a graduate student at the Pennsylvania State University researching the morphology and surface properties of aerosol particles using a wide variety of analytical techniques. He has an MS degree in chemistry.
</blockquote>
<blockquote>
Presenter: Ryan Birney (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
In Ryan’s current role at Agilent, he provides application assistance and technical support for GC and Spectroscopy. He has been supporting Agilent in technical and sales roles for the past seven years. Ryan came to Agilent from industry, and has an BS degree in Biochemistry.
</blockquote>

Agilent Technologies: Tips and Tricks: Best Practices for Column Installation and Care of GC Columns

Tips and Tricks: Best Practices for Column Installation and Care of GC Columns

Whether you are new to the practice of GC, or would like a refresher, join us as we discuss proper column installation and handling for all Agilent GCs.

Tips and Tricks: GC Column Installation and Care

Do you face difficulty in selecting the most appropriate GC column for your analysis? Are you always wondering which column will work best for your application or if the existing column will work for your application or not?
In this webinar, we will discuss:
<ul>
<li>Things to consider while choosing GC Columns
</li>
<li>GC Column types
</li>
<li>Stationary Phase Polymers
</li>
<li>Low Bleed Phases
</li>
<li>Ultra Inert columns
</li>
<li>Suitable columns for Critical Applications
</li>
</ul>
Join us in this live webinar to discuss on various aspects of GC column selection.
<blockquote>
Presenter: Sunil B Lakhmapure (Technical Support Specialist, Agilent Technologies)
</blockquote>
<blockquote>
Sunil holds 19 year plus experience in the analytical field with major exposure to LC/GC with Single Quad, Triple Quad and high resolution (QToF) mass spectroscopy. Started career in Pharma R&amp;D as a scientist with hands on experience on high end instruments like LC/MS, XRD &amp; NMR. Developed &amp; published application notes using Chromatographic techniques on real world samples/issues at various levels.
</blockquote>

Agilent Technologies: Practical Advice on GC Column Selection

Practical Advice on GC Column Selection

Do you have a new GC column to install? Do you often wonder about the nuances of GC column installation and how to get your new column up and running? Do you often wonder for how long you should condition the column and at what temperature?
In this webinar, we will discuss:
<ul>
<li>Column construction
</li>
<li>Column Unboxing
</li>
<li>Column Installation
</li>
<li>Leak and Installation Check
</li>
<li>Preventive measures for better column life 
</li>
<li>Corrective measures in case you run into a problem
</li>
</ul>
Join us in this webinar to understand a hassle-free GC column installation and how to take care of your GC column.
<blockquote>
Presenter: Dr. Rajni Mujoo (Technical Support Specialist, Chemistries &amp; Supplies Division, Agilent Technologies)
</blockquote>
<blockquote>
Dr. Rajni is working with us as Technical Support Specialist in Chemistries and Supplies Division at Agilent Technologies since 2011. She has a Ph.D degree in Food Science from CFTRI, Mysore and Post Doctorate from Department Of Food Science, Michigan State University. She also has four International Presentations &amp; 13 publications in reputed National &amp; International journals to her credit. Rajni has a total work experience of 16 yrs spread across research and Sales building expertise in different Instrument techniques.
</blockquote>

Agilent Technologies: Best Practices for GC Column Installation and Care

Best Practices for GC Column Installation and Care

Understand a hassle-free GC column installation and how to take care of your GC column.

In this webinar we will zoom into the key developments and challenges in capillary GC’.
Choice of tubing, stationary phase chemistries and deactivation chemistries will be discussed and how to reach maximum practical column life time.

Restek: ITA-SPA live | The Art and Science of next generation GC Capillary Column Production

ITA-SPA live | The Art and Science of next generation GC Capillary Column Production

Choice of tubing, stationary phase chemistries and deactivation chemistries will be discussed and how to reach maximum practical column life time.

Science of next generation GC Capillary Column Production

Column selection for solvents is basically is divided into 3 situations: Some want to replace an existing column and need a similar type to do the exact separation.
Here the challenge is to find the exact similar phase technology, which has become more difficult with the introduction of the proprietary “arylene” stabilized phases.
The other situation is that the user wants to improve the analysis. Here there are many different drivers for selecting a “different” column. This can be a shorter analysis time(cost per analysis) where shorter columns of similar ID will help out, but also smaller bore columns will allow us to maintain efficiency and reduce the run time. Some need a better separation, lower detection limits, need more robust solutions , eliminate column coupling or just have a longer column life time. Several examples will be shared.
The last situation is when user has a new application where one needs to develop a new method for. Here columns can be selected based on optimal dimensions and phase chemistries. To select the best possible phase one can now also use the ProEZGC chromatogram modeler and use this to select the phase with maximum resolution of target components.
Presenter: Jaap de Zeeuw

Restek: Column selection and optimization for Solvent analysis

Column selection and optimization for Solvent analysis

Column selection and optimization for Solvent analysis.

By attending this presentation, you will learn:
<ul>
<li>How the Agilent Inert Flow Path technology is utilized to protect samples from injection to detection.</li>
</ul>
<h5>Event Overview</h5>
Flow path inertness is vital to your analysis. It is also at the cutting edge of GC and GC/MS analysis. The Agilent Inert Flow Path ensures the inertness of every surface that touches your sample, so you can achieve the parts-per-billion—or parts-per-trillion—detection levels that today’s analyses demand.
Originally, Agilent laid the groundwork for flow path inertness with Agilent J&amp;W Ultra Inert columns, the first GC columns proven to deliver on the promise of consistent column inertness and exceptionally low column bleed. Since the introduction of Ultra Inert technology, Agilent has continued to lead the way with Ultra Inert inlet liners, fittings, ferrules, guard columns, and retention gaps.
Agilent also offers inert vials, inlets, and MS sources to reduce interactions at all points of GC and GC/MS analysis. By minimizing activity along every step of the GC and GC/MS flow path, Agilent Inert Flow Path solutions improve system performance and ensure better results. In this webinar, we will discuss vials, inlets, liners, fittings, columns, and sources that protect sample integrity and allow for low-level detection. The Agilent Inert Flow Path is compatible with both helium and hydrogen carrier gas, as well as alternative carrier gases. Specific parts and strategies to maximize analysis will be discussed.
<h5>What does it cover?</h5>
<ul>
<li>The Agilent Inert flow path, including vials, the inlet, liners, fittings, columns, and MS ionization sources and how combining them will lead to overall improvements in data quality.</li>
</ul>
<h5>Why should you attend?</h5>
<ul>
<li>Anyone looking to gain a better understanding of strategies and recommended supplies that can be implemented to speed up your GC(MS) method and what is necessary to translate a method to a different carrier gas</li>
<li>Laboratory technicians, researchers, and scientists wishing to learn more about how Agilent systems offer protection for analysis</li>
</ul>
<h5>What you need to know:</h5>
Date: 23 - 24 April, 2024
Start times:
<ul>
<li>Broadcast #1: 23 April - 10 am EDT (New York) / 3 pm BST (London) / 4 pm CEST (Paris/Berlin)</li>
<li>Broadcast #2: 23 April - 11 am PDT (Los Angeles) / 1 pm CDT (Chicago) / 2 pm EDT (New York)</li>
<li>Broadcast #3: 24 April - 10 am SGT (Singapore) / 10 am CST (Beijing) / 11 am JST (Tokyo) / 12 pm AEST (Melbourne) / 2 pm NZST (Auckland)</li>
</ul>
Duration: Approximately 60 minutes
<blockquote>
Presenter: Vanessa Abercrombie (Gas Chromatography Applications Chemist, Agilent Technologies)
</blockquote>
<blockquote>
Vanessa Abercrombie is a GC Applications Chemist at Agilent Technologies in Folsom, CA. Vanessa has a broad background in GC and GC/MS, including experience as an instrument chemist at Bode Technology in Virginia, working under contract to the FBI’s Laboratory Division. Prior to that, Vanessa worked for ETS Labs in St. Helena, CA, as an Analytical Chemist, where she researched and developed quantitative separations by GC/MS and UHPLC for beer, wine, and spirits. She holds a Master of Forensic Science from George Washington University and a Bachelor of Arts in Chemistry from Sonoma State University.
</blockquote>
<blockquote>
Presenter: Samuel Haddad, Ph.D (Application Development Chemist, Agilent Technologies)
</blockquote>
<blockquote>
Samuel Haddad is a GC Application Development Chemist at Agilent Technologies in Wilmington, Delaware. Samuel specializes in GC and GC/MS applications of trace analysis in environmental and heavy matrix samples. His specialty includes sample preparation techniques to separate analytes from matrix components and extraction from a wide variety of matrices, including water, fish, aquatic life, soil, and complex fluids. Samuel holds a Ph.D. in Environmental Science from Baylor University and a B.S. in Biology from Southern Illinois University Edwardsville.
</blockquote>

Separation Science: From Injection to Detection: Agilent Ultra Inert Is Your (Flow) Path to a Successful GC Analysis

From Injection to Detection: Agilent Ultra Inert Is Your (Flow) Path to a Successful GC Analysis

Learn how the Agilent Inert Flow Path technology is utilized to protect samples from injection to detection.

Agilent Ultra Inert Is Your Path to a Successful GC Analysis

Whether you are new to the practice of gas chromatography (GC) or would like a refresher, the installation and care of your GC column is of the utmost importance.
Join us as we discuss proper column installation and handling for all Agilent GCs, including the Intuvo 9000. We’ll also address the common modes of column degradation and some misconceptions that people have concerning column degradation. Lastly, we’ll discuss ways that you can protect and maintain your column’s performance and extend its lifetime while minimizing instrument downtime.
<blockquote>
Presenter: Ryan Birney (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
In Ryan’s current role at Agilent, he provides application assistance and technical support for GC and Spectroscopy. He has been supporting Agilent in technical and sales roles for the past seven years. Ryan came to Agilent from industry, and has an BS degree in Biochemistry.
</blockquote>
<blockquote>
Presnter: Alex Ucci (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
In his current position at Agilent, Alex provides application assistance and technical support for sample preparation products as well as GC and LC consumables. Before he joined Agilent in 2014, Alex was a graduate student at the Pennsylvania State University researching the morphology and surface properties of aerosol particles using a wide variety of analytical techniques. He has an MS degree in chemistry.
</blockquote>

Agilent: Becoming a Better Chromatographer

Chromatography Column Care 101: From Setup to Longevity

Join us as we discuss proper column installation and handling for all Agilent GCs, including the Intuvo 9000.

The evolution of MS continues to push the limits of detection in GC. As source technologies advance, column technology must advance as well. For example, increased detection of analytes also results in increased detection of background like column bleed. Therefore, GC column technology that lowers bleed can enhance your sensitivity and data accuracy.
In this webinar, we’ll examine how column attributes like bleed, thermal stability, and inertness can translate into practical data quality improvements. When used in conjunction with a novel ion source, we’ll illustrate achievable data parameters like sensitivity limits at trace levels, retention time consistencies, and data accuracy for active analytes when combining both column and source technologies.
<blockquote>
Presenter: Vanessa Abercrombie (Gas Chromatography Applications Chemist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Vanessa Abercrombie is a GC Applications Chemist at Agilent Technologies in Folsom, CA. Vanessa has a broad background in GC and GC/MS, including experience as an instrument chemist at Bode Technology in Virginia working under contract to the FBI’s Laboratory Division. Prior to that, Vanessa worked for ETS Labs in St. Helena, CA as an Analytical Chemist where she researched and developed quantitative separations by GC/MS and UHPLC for beer, wine and spirits.
</blockquote>

Agilent Technologies: Get the Most Out of Your MS: Novel Column Chemistry Raises the Bar on Sensitivity and Data Accuracy

Get the Most Out of Your MS: Novel Column Chemistry Raises the Bar on Sensitivity and Data Accuracy

We’ll examine how column attributes like bleed, thermal stability, and inertness can translate into practical data quality improvements.

Get the Most Out of Your MS: Novel Column Chemistry

Key Learning Points:
<ul>
<li>Learn about important applications in food testing and current trends</li>
<li>Understand how unique and new column selectivity is helping in food testing </li>
<li>Recieve an overview of available new column selectivity, and relevant applications</li>
</ul>
Who Should Attend:
Any new GC users in the food testing industries looking for insight on unique and new applications
<blockquote>
Presenter: Duilio Romanello (Senior Technical Specialist, Phenomenex)
</blockquote>
<blockquote>
Duilio Romanello graduated with his Bachelors of Science in Pharmaceutical Chemistry and Technology from University of Bologna. Duilio then joined Phenomenex in 2008 as an Inside Technical Sales Consultant becoming Team Leader in Italy for GC/SPE in 2010 and then for the Env/Food Team.
</blockquote>
<blockquote>
Since 2016 he has been covering the role of Account Manager for the South of Italy working remotely and acting as GC Specialist. Since November 2023 he is Senior Technical Specialist for the Technical team at Phenomenex.
</blockquote>

Phenomenex: Advancing Food Testing Using New and Unique GC Column Selectivities

Advancing Food Testing Using New and Unique GC Column Selectivities

Learn about important applications in food testing and current trends.  Recieve an overview of available new column selectivity, and relevant applications.

Food Testing Using New and Unique GC Column Selectivities

Get the most out of your mass spectrometer using the new DB-5Q and HP-5Q columns, which simplify mass spectral identification and deliver confident analysis of active compounds with unparalleled uptime of your instrument.As mass spectrometry continues to push the boundaries of sensitivity and speed, customers need a column that can do the same. The combination of our existing ultra inert (UI) and high-temperature (ht) features, combined with our new ultra low-bleed technology, enables our customers to reach lower levels of detection, accelerate sample throughput, improve data quality and reliability.<h4>Key learning objectives:</h4><ul><li>See what the new DB-5Q and HP-5Q columns can offer you by delivering ultra-low bleed, ultra-inert performance, and ultra-fast conditioning, combined with outstanding column durability.</li></ul><h4>Who should attend:</h4><ul><li>Anyone who uses gas chromatography – especially those using MS detection.</li></ul><blockquote>Presenter: Jan-Willem Marinissen (Technical Support Engineer, Agilent Technologies)Jan Willem Marinissen is a technical support engineer within the organization for the consumables and supplies division in the EMEA region.His working experience in the last decades has been in the field of chromatography in the broadest sense, that is, HPLC, sample prep and GC techniques.</blockquote>

Agilent Technologies: Get the Most Out of Your MS

Get the Most Out of Your MS

Get the most out of your mass spectrometer using the new DB-5Q and HP-5Q columns.

GCMS webinars focusing on Columns | LabRulez GCMS