<p><strong>The team of Professor&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://hocek.group.uochb.cz/en"><strong>Michal Hocek</strong></a><strong> at IOCB Prague explores the limits of the structure and function of DNA and successfully pushes forward known boundaries. An article presenting the results of their latest research has just been published in the major scientific journal </strong><i><strong>Nucleic Acids Research</strong></i><strong>. They prove that even heavily modified double helices of DNA are stable enough to be used for special applications. This discovery might expand the possibilities of utilizing modified DNA, for example, in medicine.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_b5c448f9a9.jpg" alt="ÚOCHB: Scientists from IOCB Prague are pushing the limits of DNA." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_b5c448f9a9.jpg 245w," sizes="100vw" width="1910" height="1000"></p><p>DNA consists of two long negatively charged chains that hold together even though they repel each other. This is made possible by what is known as stacking interactions and base pairing. Michal Hocek and his colleagues advanced the known limits when they modified DNA by adding an extra negative charge to each letter of the genetic code. This doubled the repulsive forces, yet the DNA double helix remained stable. They also found that such modified DNA not only holds together but that it can also be synthesized or replicated and sequenced using the enzyme DNA polymerase.</p><p><i>"Think of DNA as a scaffold on which you can attach various chemical compounds with different functions. These are small molecules, such as side chains of amino acids, which occur naturally only in peptides and proteins. In current medicine, we are able to use these molecules only to a relatively limited extent. The reason is that they are markedly unstable and get decomposed rapidly when inside an organism. One solution to this would be a stable skeleton to which they could be firmly attached. And DNA could be just such a base structure in the future,"</i> says Prof. Michal Hocek.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_Prof_Michal_Hocek_Distinguished_Chair_and_head_of_Bioorganic_and_Medicinal_Chemistry_of_Nucleic_Acids_0a8c924ac4.jpg" alt="ÚOCHB / Tomáš Belloň: Prof. Michal Hocek, Distinguished Chair and head of Bioorganic and Medicinal Chemistry of Nucleic Acids." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Scientists_from_IOCB_Prague_are_pushing_the_limits_of_DNA_Prof_Michal_Hocek_Distinguished_Chair_and_head_of_Bioorganic_and_Medicinal_Chemistry_of_Nucleic_Acids_0a8c924ac4.jpg 234w," sizes="100vw" width="1500" height="1001"></p><p>The aim of this research carried out at IOCB Prague is to create DNA molecules that will mimic other chemical compounds. This would enable us to leverage the medicinal potential of certain biomolecules that are difficult to retain in the body. Examples of such biomolecules are the already mentioned peptides or proteins.</p><p>The Hocek group has already made significant progress, although research in this direction is at its beginning worldwide. The team has, for example, succeeded at developing a novel modified aptamer, which is a short DNA sequence that can bind to a specific target molecule, most frequently a protein. Aptamers have similar properties to antibodies, but they are much more stable. For this reason, aptamers can potentially replace antibodies employed in medicine. However, the number of approved therapeutic aptamers globally can still be counted on the fingers of one hand.</p><p>The current research exploring the limits of DNA is part of a larger project led by Michal Hocek, for which he has secured a prestigious EXPRO grant from the Czech Science Foundation. This is the second time its results have drawn interest from the journal <i>Nucleic Acids Research</i>. Previously, scientists from IOCB Prague published a method for the enzymatic synthesis of fully artificial DNA. During this synthesis, all nucleotides forming natural DNA are replaced by their modified versions with attached hydrophobic (i.e. water-repelling) molecules.</p>

Scientists from IOCB Prague are pushing the limits of DNA

<p><strong>Researchers from IOCB Prague are furthering the understanding of how medicines work and what it takes to develop their most effective variants. In one current study, they have focused on the disease caused by the protozoan parasite </strong><i><strong>Trichomonas vaginalis</strong></i><strong>, especially because of the recent appearance of strains that are resistant to conventional treatment. In an effort to find a new weak spot of this parasite, the </strong><a target="_blank" rel="noopener noreferrer" href="https://boura.group.uochb.cz/en"><strong>research group</strong></a><strong> led by Dr. Evžen Bouřa has succeeded in preparing a key enzyme complex – the proteasome. This has made it possible to gain knowledge that is indispensable for the development of new effective medicines. The research was carried out in collaboration with colleagues from the University of California San Diego. An article presenting the work has been published in the scientific journal </strong><i><strong>Nature Communications</strong></i><strong>.</strong></p><p>The proteasome is a complex protease that works as a device for recycling old proteins in cells. It is a cylindrical enzyme complex composed of seven subunits arranged in four superposed circles. When old proteins enter this cylinder, they get broken down into small pieces later used by the cell to make new proteins. If it functions incorrectly, old proteins accumulate, leading to the cell’s demise. This is why the blocking of proteasome activity is used, for example, against certain types of malignant tumours.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Vyzkum_vedcu_z_UOCHB_pomaha_vylepsovat_ucinky_lecivych_latek_Dr_Evzen_Boura_vedouci_vedecke_skupiny_Strukturni_biologie_membran_UOCHB_783ec20050.jpg" alt="IOCB Prague / Tomáš Belloň: Dr. Evžen Bouřa, head of the Structural Membrane Biology group at IOCB Prague." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Tomas_Bellon_Vyzkum_vedcu_z_UOCHB_pomaha_vylepsovat_ucinky_lecivych_latek_Dr_Evzen_Boura_vedouci_vedecke_skupiny_Strukturni_biologie_membran_UOCHB_783ec20050.jpg 234w," sizes="100vw" width="1500" height="1001"></p><div><p>In the same way, it should also be possible to treat the widespread sexually transmitted infection trichomoniasis, which increases the risk of contracting HIV. The aim is therefore to identify substances that block the function of the proteasome inside <i>Trichomonas vaginalis</i> cells. However, the proteasome of this single-cell organism had never been satisfactorily isolated, so the research group from IOCB Prague prepared an artificial proteasome that is identical to the natural one. Curiously, they used insect cells to do so. This part of their research, on which the success of the whole project was hinged, proved the most complicated. That the team has prevailed in describing the previously unknown structure of the parasite’s proteasome is therefore of critical importance.</p><p><i>‘The proteasome looks the same in every animal or protozoan, but the details of this cylindrical structure differ. It is these details that we need to know in order to create a substance that is toxic to the parasite but not harmful to the human body. That is a crucial precondition for drug development. Our greatest success is that we have been able to prepare a recombinant, artificial proteasome that can provide us with the necessary information,’</i> explains Evžen Bouřa.</p><p>The researchers used advanced electron microscopy, allowing them to see almost every single atom. Armed with this capability, they tested the effects of two potential proteasome-inhibiting substances. They saw how they bind to the active site of the proteasome and under what circumstances the proteasome stops working, which is fatal to the cell of the parasite.</p><p>The research was carried out within the <a target="_blank" rel="noopener noreferrer" href="https://nivb.cz/en/">National Institute of Virology and Bacteriology</a> (LX22NPO5103), funded by the <a target="_blank" rel="noopener noreferrer" href="https://www.uochb.cz/en/exceles">EXCELES</a> program.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_vedcu_z_UOCHB_pomaha_vylepsovat_ucinky_lecivych_latek_1_8ff5bf4e71.jpg" alt="IOCB Prague: Dr. Evžen Bouřa, head of the Structural Membrane Biology group at IOCB Prague." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_vedcu_z_UOCHB_pomaha_vylepsovat_ucinky_lecivych_latek_1_8ff5bf4e71.jpg 245w," sizes="100vw" width="1386" height="632"></p><p>&nbsp;</p></div>

Scientists from IOCB Prague help to improve medical drugs

<p><strong>In the week from October 14, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Thermo Fisher Scientific: Solutions for environmental and food contaminant testing</strong></h5><div><div><ul><li><div>Tu, 15.10.2024 10:30 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4238">Registration</a></div></li></ul></div><p>New and advancing workflows to meet and exceed European regulations.</p></div><h5><strong>2.&nbsp;Agilent Technologies: MassHunter Acquisition Q-TOF Part II – Advance Settings</strong></h5><div><div><ul><li><div>Tu, 15.10.2024 14:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4343">Registration</a></div></li></ul></div><p>Join us for an in-depth exploration of advanced settings in MassHunter Acquisition for Q-TOF systems.</p></div><h5><strong>3.&nbsp;Agilent Technologies: Sealing the Deal: Strategies for Leak-Free GC</strong></h5><div><div><ul><li><div>Tu, 15.10.2024 17:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/3920">Registration</a></div></li></ul></div><p>We explore how to identify signs of leaks, address any existing leaks, and prevent future leaks.</p></div><h5><strong>4.&nbsp;Phenomenex: Solid Phase Extraction Troubleshooting Tips and Tricks</strong></h5><div><div><ul><li><div>Tu, 15.10.2024 19:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4338">Registration</a></div></li></ul></div><p>Identify the common challenges associated with solid phase extraction methods.</p></div><h5><strong>5.&nbsp;Technology Networks/Thermo Fisher Scientific: Streamlining Data for Superior Therapeutic Manufacturing</strong></h5><div><div><ul><li><div>We, 16.10.2024 17:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4377">Registration</a></div></li></ul></div><p>This webinar explores how to implement digitization to accelerate decision-making, meet regulatory demands and eliminate bottlenecks in biotherapeutic development.</p></div><h5><strong>6.&nbsp;Waters Corporation: Empower Tips: Ask Me Anything About Processing Data - Part 2</strong></h5><div><div><ul><li><div>Th, 17.10.2024 16:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4360">Registration</a></div></li></ul></div><p>This is the second in our three-part Ask Me Anything webinar series on one of the most frequently asked about topics - processing data.</p></div><h5><strong>7.&nbsp;Bruker: Introduction to Nanoscale Infrared Spectroscopy and Imaging with Photothermal AFM-IR</strong></h5><div><div><ul><li><div>Th, 17.10.2024 17:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4361">Registration</a></div></li></ul></div><p>We kindly invite you to join us for this live webinar: An Introduction to Nanoscale Infrared Spectroscopy and Imaging with Photothermal AFM-IR.</p></div><h5><strong>8.&nbsp;SelectScience/SepSolve Analytical: Investigating the impact of volatile compounds on the flavor profiles of foods and drinks</strong></h5><div><div><ul><li><div>Th, 17.10.2024 17:00 CEST</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4358">Registration</a></div></li></ul></div><p>Explore how innovative extraction and enrichment techniques, combined with state-of-the-art GC–MS analyses can deliver more detailed and accurate volatile profiles.</p></div>

Webinars LabRulezGCMS Week 42/2024

Article

Webinars

Scientific article

Science and research

Video

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Ústav organické chemie a biochemie AV ČR

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Agilent Technologies

LECO

SelectScience

<p><strong>E&amp;L compounds span a range from volatile or semi volatile to nonvolatile and elemental. No single analytical tool can analyze all E&amp;Ls. Whether you are scouting or conducting a targeted screening, suspect screening, or nontargeted screening, Agilent can help with a wide range of analytical technologies and years of expertise for the accurate identification and quantification of potential E&amp;Ls.</strong></p>
<p><strong>Register now and attend this webinar to learn:</strong></p>
<ol>
<li><p>Latest trends &amp; applications in E&amp;L analysis</p>
</li>
<li><p>Advanced GC/MS | GC/HR-MS based workflows and solutions offered by Agilent</p>
</li>
<li><p>Role of statistical analysis in extractable profiling</p>
</li>
<li><p>Regulatory landscape in E&amp;L analysis</p>
</li>
<li><p>Understanding the quantitation approach</p>
</li>
</ol>
<p>*<em>Register for all the webinars and get complementary access to The experts guide to Pharmaceutical Impurity Analysis e-book.</em></p>
<blockquote>
<p><strong>Presenter:</strong> Dr. Kuldeep Sharma (Sales Development Manager - Pharma, Agilent Technologies)</p>
</blockquote>
<blockquote>
<p>Kuldeep Sharma has over 19 years of experience in area/s of Bioanalytical research, Drug metabolism &amp; pharmacokinetics and Pharma regulatory compliance. He has accomplished PhD in Biotechnology. His professional journey covers over 12 years in Analytical research (associated with R&amp;D’s of Zydus Cadila, Lambda, Pliva and Jubilant Biosys) and last 7 years in analytical instruments sales, marketing &amp; business development. With over 21 research articles published in international Journals, He presents convention of continues learning.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Dr. Soma Dasgupta (Application Engineer - GC/MS, Agilent Technologies)</p>
</blockquote>
<blockquote>
<p>With over 17 years of extensive experience in gas chromatography, Dr. Soma has explored diverse facets of this analytical technique, addressing inquiries across various sectors, from ensuring food safety to advancing pharmaceutical analyses. Her academic journey includes doctoral research at the University of Pune, where her focus was on developing comprehensive methods for analyzing agro-chemicals in fruits and vegetables.</p>
</blockquote>
<blockquote>
<p>Previously, having served as a Field Application Specialist for three years, she honed her expertise in the practical applications of gas chromatography. Since joining Agilent Technologies, she have been an integral part of a dynamic team dedicated to providing solutions that cater to our customers&#39; analytical needs. Her specialization encompasses multi-residue method development, with a specific focus on pesticides and environmental applications, as well as expertise in identifying genotoxic impurities in pharmaceuticals.</p>
</blockquote>
<blockquote>
<p>Throughout her career, She has contributed significantly to the field, with a portfolio of more than 25 publications, application notes, and a book chapter.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Mr. Ankush Sharma (Regional Marketing Program Manager- APAC (Pharma &amp; Biopharma), Agilent Technologies)</p>
</blockquote>
<blockquote>
<p>Ankush Sharma is a seasoned professional with over 12 years of extensive experience in sales and marketing across the pharmaceutical and biopharmaceutical sectors. His professional journey commenced with a strong educational foundation, earning a Master&#39;s degree in Biotechnology. Building upon this knowledge, he furthered his academic pursuits by obtaining a Master&#39;s in Business Administration with a specialization in Sales and Marketing, demonstrating his commitment to blending scientific understanding with strategic business acumen. For the past five years, he has been an integral part of Agilent, serving as the Regional Marketing Program Manager for the India and now Asia-Pacific (APAC) region for Pharma and Biopharma Markets. </p>
</blockquote>


Agilent: Advanced GC/MS | GC/HR-MS Based Workflow for Extractable and Leachable Analysis

Advanced GC/MS | GC/HR-MS Based Workflow for Extractable and Leachable Analysis

Agilent can help with a wide range of analytical technologies and years of expertise for the accurate identification and quantification of potential E&Ls.

GC/MS | GC/HRMS for Extractables and Leachables

<p><strong>Nick Jones will regularly invite key leaders of the NTS space from all industries to present and discuss their groundbreaking work. This series promises not only to delve deeper into the intricacies of non-targeted screening but also to foster collaboration and knowledge exchange among experts and enthusiasts alike. Secure your spot now and embark on a journey of discovery in chemical analysis, with each instalments of our monthly webinar series delivering fresh perspectives and invaluable insights.</strong></p>
<blockquote>
<p><strong>Presenter:</strong> Dr. Katelynn A. Perrault Uptmor (William &amp; Mary, USA)</p>
</blockquote>
<blockquote>
<p>Dr. Perrault Uptmor, PI of the Nontargeted Separations Laboratory at William and Mary, will present on her work of screening samples using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GCXGC-TOFMS) in forensic applications as novel types of evidence appear. Dr. Perrault Uptmor will detail initial approaches to method development for new samples and show recent applications related to chemical profiling of deposited fingermarks, organic gunshot residue and decomposition odor. She will further discuss the implications of GCXGC-TOFMS sample visualization in the context of expert testimony for communicating screening processes in forensic casework within the courtroom.</p>
</blockquote>


LECO: Non-targeted screening in forensics, a discussion of method development and screening of forensic samples using GCXGC-TOFMS

Non-targeted screening in forensics, a discussion of method development and screening of forensic samples using GCXGC-TOFMS

Non-targeted screening in forensics using GCXGC-TOFMS

<p><strong>LECO will regularly invite key leaders of the NTS space from all industries to present and discuss their groundbreaking work. This series promises not only to delve deeper into the intricacies of non-targeted screening but also to foster collaboration and knowledge exchange among experts and enthusiasts alike. Secure your spot now and embark on a journey of discovery in chemical analysis, with each instalments of our monthly webinar series delivering fresh perspectives and invaluable insights.</strong></p><blockquote><p><strong>Presenter:</strong> Prof. John Langley (University of Southampton, UK)</p><p>Prof. John Langley, Head of Characterisation and Analytics, Chemistry, from University of Southampton, a leading expert in sustainable fuels, will present on the latest advancements in renewable and sustainable fuel analysis. As the demand for eco-friendly alternatives like Sustainable Aviation Fuel (SAF) and Hydrotreated Vegetable Oils (HVOs) grows, so do the analytical challenges associated with their stability, complexity, and integration into traditional fuel matrices, such as diesel.</p><p>In this session, Prof. Langley will explore how these next-generation fuels introduce new hurdles for quality measurement, requiring innovative hyphenated techniques, including GC-MS and comprehensive two-dimensional gas chromatography (GCxGC-MS). Attendees will gain insights into the crucial role of these methods in evaluating fuel quality, especially as renewable fuels are blended with conventional fuels.</p><p>He will further discuss how GCxGC-MS is pivotal for comparing and analyzing different HVOs, providing clarity on how these tools enable the screening of differences and similarities across various renewable fuel sources. This webinar will offer invaluable perspectives for anyone involved in fuel analytics, energy sustainability, or related industries.</p></blockquote>

LECO: Non-Targeted Screening in Sustainable Fuels: Exploring Method Development and Fuel Quality Assessment Using GCxGC-MS and Hyphenated Techniques

Non-Targeted Screening in Sustainable Fuels: Exploring Method Development and Fuel Quality Assessment Using GCxGC-MS and Hyphenated Techniques

Exploring Method Development and Fuel Quality Assessment Using GCxGC-MS and Hyphenated Techniques

Non-Targeted Screening in Sustainable Fuels

<p><strong>This session will provide a comprehensive introduction to the user interface, ensuring you can navigate with ease. Discover the various acquisition modes available and learn how to select the best one for your specific application.</strong></p><p>Additionally, we will explore the innovative Intelligent Reflex feature, highlighting its benefits in boosting your productivity.</p><p>Whether you’re new to MassHunter or looking to refine your skills, this webinar is designed to enhance your understanding and efficiency.</p><blockquote><p><strong>Presenter:</strong> Christian Hegmanns (Application Specialist LC/MS, Agilent Technologies, Waldbronn, Germany)</p><p>Christian Hegmanns is a state-certified food chemist and works at Agilent as an LC/MS application specialist.</p><p>With over 10 years of experience in the field of instrumental analysis, Christian develops customer-oriented solutions for a variety of applications with a focus on food analysis.</p></blockquote>

Agilent Technologies: MassHunter Masterclass Months

MassHunter Acquisition Q-TOF Part I – Basic Overview

Join us for an insightful webinar where we delve into the essentials of MassHunter Acquisition Q-TOF. 

<p><strong>This webinar will guide you through optimizing your Q-TOF for superior data quality by selecting the most suitable tune mode for your samples.</strong></p><p>We will delve into various MS acquisition modes, including MS only, All Ions (QRAI), Auto MS/MS (directed MS/MS; targeted MS/MS), and PRM mode.</p><p>Learn how to fine-tune method settings to enhance your data quality and achieve the best analytical results. Whether you’re a seasoned user or new to QTOF, this session will provide valuable insights to elevate your mass spectrometry.</p><blockquote><p><strong>Presenter:</strong> &nbsp;Stefan Schaebler (Application Specialist LC/MS, Agilent Technologies)</p><p>Stefan completed his PhD in Biology, specializing in LC-MS-based lipidomics and metabolomics. Following his doctoral studies, he joined Agilent Technologies as an LC/MS Application Specialist. In this role, Stefan focuses on small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</p></blockquote>

MassHunter Acquisition Q-TOF Part II – Advance Settings

Join us for an in-depth exploration of advanced settings in MassHunter Acquisition for Q-TOF systems.

<p><strong>Join us for an insightful webinar where we will explore the critical aspects of differentiating good from bad data and how this distinction can significantly influence your results. From screening to quantification, discover the value of targeted data analysis workflows using non-targeted data with our innovative software and hardware.</strong></p><p>Find by Formula algorithm. Learn to identify the most suitable MS/MS approach for your experiments, initiate quantitation for your compounds of interest, and incorporate retention times (RTs) and MS/MS spectra into a custom database and library.</p><p>This session is designed to enhance your understanding and application of Q-TOF data analysis, ensuring robust and reliable outcomes.</p><blockquote><p><strong>Presenter:</strong> Hannah Florance (Agilent Technologies)</p><p>Hannah has had multiple roles in the life sciences, starting as a protein chemist, before moving into proteomics and then metabolomics. A major part of her time working in academia involved running LC and GCMS core facilities supporting projects ranging from synthetic biology to cancer research. She is currently an LCMS applications specialist for Agilent.<br><br><strong>Presenter:</strong> Stefan Schaebler (Application Specialist LC/MS, Agilent Technologies)</p><p>Stefan completed his PhD in Biology, specializing in LC-MS-based lipidomics and metabolomics. Following his doctoral studies, he joined Agilent Technologies as an LC/MS Application Specialist. In this role, Stefan focuses on small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</p></blockquote>

MassHunter Qual – The Solid Pillar in Q-TOF Data Analysis

We will explore the critical aspects of differentiating good from bad data and how this distinction can significantly influence your results.

<p><strong>Join our upcoming webinar on the MassHunter Quant Screener Tool to discover how to harness the power of quantitative analysis for effective screening and identification of potential suspect compounds.</strong></p><p>This session will provide in-depth guidance on creating methods from PCDL databases, evaluating result parameters, and generating straightforward summary reports. Additionally, learn how retention time (RT) prediction can enhance your screening process by significantly accelerating and simplifying large database searches.</p><p>Don’t miss this opportunity to elevate your analytical capabilities!</p><blockquote><p><strong>Presenter:</strong> &nbsp;Jonathan Spencer (Application Specialist, Agilent Technologies)</p><p>Jonathan studied BSc Natural Sciences at the University of Nottingham and later went on to Sheffield Hallam University to study a MSc in Forensic Science.</p><p>Following graduation, he spent 2 years as a Confirmatory Analyst in an anti-doping and forensic toxicology lab, before joining Agilent as an LC/MS Applications Scientist. At Agilent, he focuses on small molecule applications using LC/TQ and LC/Q-TOF in fields of like food, forensic and environmental analysis.</p></blockquote>

MassHunter Quant Screener Tool

Discover how to harness the power of quantitative analysis for effective screening and identification of potential suspect compounds. 

<p><strong>Join us on the hunt for the needle in the haystack!</strong></p><p>This session will delve into best practices for untargeted feature finding, focusing on achieving the optimal balance between sample coverage and processing speed using Profinder and the new MassHunter Explorer. We will explore techniques to differentiate between features and noise by applying the right filters for quality checking your data. Additionally, the webinar will cover essential aspects of compound identification, including database matching, formula generation, and structure elucidation.</p><p>This is a must-attend event for anyone looking to enhance their analytical capabilities and streamline their data processing workflows.</p><blockquote><p><strong>Presenter:</strong> &nbsp;Stefan Schaebler (Application Specialist LC/MS, Agilent Technologies)</p><p>Stefan completed his PhD in Biology, specializing in LC-MS-based lipidomics and metabolomics. Following his doctoral studies, he joined Agilent Technologies as an LC/MS Application Specialist. In this role, Stefan focuses on small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</p></blockquote>

Finding the Needle in the Haystack Part I: From Complex Samples to Compounds of Interest

The best practices for untargeted feature finding, focusing on achieving the optimal balance between sample coverage and processing speed.

From Complex Samples to Compounds of Interest

<p><strong>The hunt goes on, let's find the needle in the haystack:</strong></p><p>Join us for an insightful webinar where we delve into the world of chemometrics to enhance your data interpretation skills. Learn how to select the appropriate statistical tools to make sense of your data and identify features of interest by visualizing trends and changes using various clustering and grouping approaches. We will also cover the construction of class prediction models to differentiate between sample cohorts effectively.</p><p>Finally, gain a deeper understanding of your findings by mapping them onto relevant metabolomic pathways, providing essential context for your research.</p><blockquote><p><strong>Presenter:</strong> Hannah Florance (Application Specialist LC/MS, Agilent Technologies)</p><p>Hannah has had multiple roles in the life sciences, starting as a protein chemist, before moving into proteomics and then metabolomics. A major part of her time working in academia involved running LC and GCMS core facilities supporting projects ranging from synthetic biology to cancer research. She is currently an LCMS applications specialist for Agilent.<br><br><strong>Presenter:</strong> Shaun Reeksting (Application Specialist LC/MS, Agilent Technologies)</p><p>Shaun completed his PhD in Biochemistry, specializing in molecular parasitology a focus in metabolomics. Following his doctoral studies, he worked in accredited industry laboratories and academia core-facilities before joining Agilent Technologies as an LC/MS Application Engineer.</p><p>In this role, Shaun focuses on environmental small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</p></blockquote>

Finding the Needle in the Haystack Part II; All Things Chemometric

Join us for an insightful webinar where we delve into the world of chemometrics to enhance your data interpretation skills.

All Things Chemometric

<p><strong>Volatile profiling of food and beverages is crucial for understanding and enhancing their quality, safety, and consumer appeal. Analysing these volatiles presents several challenges due to the diversity of chemical classes, their varying concentrations, and the complex matrices involved, which can be problematic for conventional gas chromatography–mass spectrometry (GC–MS) approaches.</strong></p><p>Join Prof. Kieran Kilcawley, Principal Research Officer at Teagasc Food Research Centre and Adjunct Professor, University College Cork and Technological University Dublin, as he explores how innovative extraction and enrichment techniques, combined with state-of-the-art GC–MS analyses, can overcome these difficulties and deliver more detailed and accurate volatile profiles.</p><p><strong>Key learning objectives</strong></p><ul><li>Understand the critical role volatile compounds play in shaping the flavor and overall quality of food and beverages</li><li>Learn about the latest techniques for the sensitive extraction and analysis of aroma-active compounds, including high-capacity sorptive extraction and comprehensive two-dimensional gas chromatography (GCxGC).</li><li>Explore practical applications through case studies, including volatile profiling of whiskey, analysis of fatty acids in dairy products, and evaluating the impact of cooking temperature on the volatile profile of beef</li></ul><p><strong>Who should attend?</strong></p><ul><li><strong>Food scientists</strong> who want to understand more about profiling, odour perception, sensory evaluation, and food authenticity analysis.</li><li><strong>R&amp;D food scientists and analytical scientists</strong> who want to enhance their understanding of analysing complex samples.</li><li><strong>GC(–MS) users</strong> eager to hear about the latest instrument developments.</li></ul><p><strong>Certificate of attendance</strong></p><p>All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.</p><blockquote><p><strong>Presenter:</strong> Prof. Kieran Kilcawley (Principal Research Officer, Teagasc Food Research Centre and Adjunct Professor, University College Cork and Technological University Dublin)</p><p>Prof. Kieran Kilcawley oversees the flavor chemistry facility at Teagasc, where he conducts extensive research on flavors in various foods and beverages. He became an Adjunct Professor in the Department of Food and Nutritional Sciences at University College Cork in 2020 and in the School of Food Science and Environmental Health at the Technological University Dublin in 2024. His expertise encompasses advanced gas chromatography and mass spectrometry, including olfactometry, as well as aroma extraction, method development and validation, data processing, and chemometrics.</p><p><strong>Moderator:</strong> Carrie Haslam (Associate Editor, SelectScience)</p></blockquote>

SelectScience: Investigating the impact of volatile compounds on the flavor profiles of foods and drinks

Investigating the impact of volatile compounds on the flavor profiles of foods and drinks

Innovative extraction and enrichment techniques with GC–MS analyses for detailed and accurate volatile profiles.

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