Broadband Laser-Based Infrared Detector for Gas Chromatography

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 30th September 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring to you applications by Agilent Technologies, Waters Corporation, and Thermo Fisher Scientific, and a poster from <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/companies/296">ASMS</a> by Shimadzu!<h4>1. Shimadzu: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/TP_093_Analysis_of_PFAS_in_Water_Final_05292024_8fa9fcb27d.pdf">Analysis of Volatile PFAS in Water Using Head-Space Solid Phase Microextraction- Gas Chromatography/Mass Spectrometry (HS-SPME GC/MS)</a></h4><ul><li>Poster / <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/companies/296">ASMS</a>&nbsp;</li></ul>Introduction&nbsp;Per- and Polyfluoroalkyl Substances (PFAS) are environmental pollutants with recognized health and environmental concerns due to their probable toxicity, persistence, and ubiquitousness throughout the environment, and consumer and industrial products. PFAS encompass a large family of chemicals with varying physicochemical properties. These properties not only affect their toxicity and environmental fate, but also complicates chemical analysis.In this work, a Head-Space Solid Phase Microextraction-Gas Chromatography/Mass Spectrometry (HS-SPME GCMS) analytical method was developed to analyze six classes of volatile PFAS in water. This HS-SPME method presents the advantage of simplifying sample extraction and handling for the analysis of volatile PFAS in water, hence, minimizing operational costs, potential errors, and risk of sample-cross contamination.ConclusionThis study demonstrated the use of a Shimadzu GC/MS-QP2020 NX single quadrupole instrument configured with the AOC-6000 Plus multifunctional autosampler and an automated head space solid phase microextraction unit for measurement of volatile PFAS compounds in water. Linear calibration curves were obtained for all compounds (R 2 ≥ 0.993 and RF %RSD &lt; 20 %). The HS-SPME GC/MS-QP2020 NX method demonstrated qualitative and quantitative capability of analyzing PFAS compounds.<h4>2. Thermo Fisher Scientific: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_003028_gc_ms_isq_epa_vocs_an003028_na_en_7646797ef5.pdf">Analysis of volatile organic compounds in drinking water according to U.S. EPA Method 524.4</a></h4><ul><li>Application</li></ul>GoalDemonstration of an analytical method that meets the requirements outlined in U.S. EPA Method 524.4 for the quantitation of volatile organic compounds (VOCs) in drinking water, using the Teledyne LABS Tekmar Lumin Purge and Trap (P&amp;T) concentrator paired with the AQUATek LVA autosampler system along with a Thermo Scientific™ ISQ™ 7610 MS system coupled with a Thermo Scientific™ TRACE™ 1610 gas chromatograph (GC) and Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS). Target analyte linearity, method detection limit (MDL), minimum report level (MRL), and mid-point precision and accuracy were assessed to evaluate method performance.Keywords: EPA, U.S. EPA 524.4, VOCs, phthalates, trace analysis, gas chromatography, single quadrupole mass spectrometry, selected ion monitoring, sensitivity, GRO, THM, volatiles, environmental lab, environmental sample analysis, analytical testing laboratories, ISQ 7610 MS, TRACE 1610 GC, GC-MS.IntroductionVolatile organic compounds (VOCs) are man-made contaminants in various products that pose environmental and public health risks. These compounds are regulated in drinking water, and laboratories follow regulations including U.S. EPA Method 524.2.1 A previous application note described U.S. EPA Method 524.2,2,3 which is the most common method for VOC water testing in the USA. U.S. EPA Method 524.4 is an updated method that allows for nitrogen to be used as the purge gas, thus reducing helium consumption, and is now being more widely used. Targeting 75 VOCs, this method differs by offering more method parameter flexibility but stricter quality control, including the stringent calculation of the minimum reporting level for evaluating calibration checks.Implementing U.S. EPA Method 524.4 can present multiple challenges for laboratories. Striking a balance between optimized method conditions and meeting the acceptance criteria, like detection limit requirements for various compound concentrations, is pivotal. Another major hurdle is managing the water matrix to minimize GC-MS system water introduction, which could lead to detrimental effects and delay sample reporting, thereby increasing public safety risks. Ultimately, maintaining consistency in test results to avoid sample reanalysis is crucial. Another factor for laboratories to consider is the fluctuating cost of helium, which is the analytical gas of choice for this analysis. Reducing the use of helium—a limited resource—will enable the laboratory to reduce operational costs and increase profitability.The following evaluation describes the use of the ISQ 7610 GC-MS system coupled with a TRACE 1610 GC with the Thermo Scientific™ HeSaver-H2Safer™ split/splitless injector and Teledyne LABS Tekmar Lumin P&amp;T concentrator paired with the AQUATek LVA autosampler for U.S. EPA Method 524.4.ConclusionThe combined solution of the TRACE 1610 GC coupled with the ISQ 7610 system and the Tekmar Lumin P&amp;T concentrator with the AQUATek LVA autosampler system successfully addresses the challenges of VOC analysis and provides a robust, sensitive solution needed for ensuring maximized sample throughput and regulatory method compliance for U.S. EPA Method 524.4.<ul><li>Excellent linearity for all compounds was demonstrated with the linear regression (r²≥0.995) of the calibration response factors passing all method requirements.</li><li>MDL and precision for seven 0.5 ppb standards showed no interference from excessive water and produced very reproducible results.</li><li>The precision for n=30 samples over 245 injections displayed &lt;30% RSD for all compounds as the method requires and an average recovery of 91%.</li><li>Utilizing HeSaver-H2Safer technology reduced helium consumption for the method by 4 times, which provides a significant cost savings.</li></ul><h4>3. Waters Corporation: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720008298_en_db4158391c.pdf">Extractables Analysis of Nasal Spray Devices Using Gas Chromatography and High- Resolution Mass Spectrometry With Soft Ionization</a></h4><ul><li>Application</li></ul>AbstractDue to concern about the safety of components from plastic, it is crucial to screen for and identify potential extractables and leachables (E&amp;L) in pharmaceutical packaging and medical devices. For volatile, and semi-volatile compounds, gas chromatography-mass spectrometry (GC-MS) with electron ionization (EI) is typically used. Compounds are determined using scientific libraries; however, where compounds are not listed or where the sensitivity of EI-MS is not sufficient, the identification process becomes challenging.Here, we describe an E&amp;L screening experiment using gas chromatography and a quadrupole time of flight high-resolution mass spectrometer (QToF-HRMS) with atmospheric pressure gas chromatography (APGC) for soft ionization. A data independent acquisition (DIA) strategy is utilized to aid screening and elucidation which are combined in a screening software solution.Benefits<ul><li>GC-QToF MS with APGC as an orthogonal technique to LC-QToF-MS allows for comprehensive compound coverage with increased sensitivity compared to typical EI techniques</li><li>The UNIFI™ application within the waters_connect™ platform provides customized workflows to simplify screening and structural elucidation in complex datasets</li><li>The Xevo™ G3 QTof Mass Spectrometer enables confident identification of E&amp;L components in complex matrices through novel ion optics and detection system which maximize transmission</li><li>Soft ionization using the APGC™ source allows for the detection of molecular ions from which elemental compositions can be derived to aid compound identification and confirmation&nbsp;</li><li>MSE, a data independent acquisition, increases confidence in identifications when screening against a library and provides additional information to aid structural elucidation</li></ul>Conclusion&nbsp;When undertaking E&amp;L screening analyses it is important to use a range of analytical techniques to account for different compound chemistries. GC-QToF MS with APGC as an orthogonal technique to LC-QToF-MS allowed for comprehensive compound coverage with increased sensitivity compared to typical EI techniques. Due to the soft ionization of APGC, the intact molecular ion is often present in the spectra. This combined with a data independent acquisition, MSE mode, utilizes full spectral acquisition of the accurate mass information of both precursor and fragment ions.This approach boosts confidence in component identifications when screening against an MS/MS library, while minimizing false positives. For instance, in the LC-QToF-MS there were just under 40 potential compounds matches in sample E48 after considering factors such as retention time match, mass accuracy below 3 ppm, and the presence of at least one fragment ion. A further 38 compound matches in sample E48 were tentatively identified using GC-QToF MS with APGC, with mass accuracy below 3 ppm, and the presence of at least one fragment ion.MSE data also aids in the structural elucidation of unknown substances by utilizing accurate mass and corresponding fragment ions, facilitating comprehensive characterization. This data increases confidence in identifications of components and assists with structural elucidation of unknowns to ultimately aid full characterization. For example an unknown with protonated m/z 284.2703 was tentatively identified as a N-(2-(1-piperazinyl)ethyl)decanamide (mass error 2.33 ppm) by the software.For the extractables analysis of nasal sprays the UNIFI application within the waters_connect platform provided SST benchmarking, screening against a library, summary plots to identify trends, filtering of AET levels, binary compare mode to isolate relevant unknowns, and a Discovery Tool for elucidation of unknowns.<h4>4. Agilent Technologies: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_voc_rubber_gasket_extracts_gc_msd_5994_7777en_agilent_6a0a6bf7d0.pdf">Analysis of Volatile Compounds Identified in Rubber Gasket Extracts Using GC/MSD and High-Resolution GC/Q-TOF</a></h4><ul><li>Application</li></ul>AbstractChemicals that are part of polymeric container closure systems (CCS) and drug delivery systems have the potential to migrate into drug products during manufacturing, storage, transport, and delivery, and must be identified in the final products to ensure their safety.This application note presents a rubber gasket extractables study using a unit mass resolution gas chromatography/mass selective detector (GC/MSD) and a high-resolution gas chromatography/quadrupole time-of-flight (GC/Q-TOF) mass spectrometer to establish a process for identifying GC-amenable extractables and leachable (E&amp;L) compounds.IntroductionElastomeric gaskets, plungers, and O-rings are common sources of leachable compounds in the manufacturing, storage, and delivery of drug products. E&amp;Ls derived from elastomeric components may impact the stability and efficacy of small and large molecule drug products1, and therefore need to be characterized thoroughly. Exposure to some E&amp;L chemicals, such as phthalates and nitrosamines, even at low levels, may cause safety concerns.2 Chemicals derived from the elastomer manufacturing process typically include accelerators, activators, antioxidants, fillers, plasticizers (including phthalates), mold release agents, and other additives3 that may leach into the final product. Some additives present in elastomer packaging materials may also contain polycyclic aromatic hydrocarbons (PAHs)4 and aliphatic hydrocarbons.GC/MS is a commonly used technique for analyzing volatile and semivolatile organic compounds in the E&amp;L space. This study demonstrates the capabilities of GC/MSD to identify GC-amenable compounds present in a solvent extract of a rubber gasket by leveraging chromatographic deconvolution in combination with retention index (RI)-based filtering. Adding a high-resolution accurate mass GC/Q-TOF into the E&amp;L workflow provided a higher number of identified chemicals. It also increased confidence in compound identification and enabled structure elucidation of unknown compounds.The study was performed in the Network Workstation configuration using Agilent OpenLab Electronic Content Management (ECM) XT as the data repository. This configuration enabled tools that facilitate compliance with various national and EU electronic record regulations, including audit trails, user authentication, role-based permission controls, and remote data storage.5ConclusionThe GC/MSD is an effective and accessible tool for the analysis of volatile and semivolatile compounds in complex E&amp;L extracts. The established workflow includes deconvolution and an RI-based library search with the data acquisition performed in a compliant environment.The high-resolution Agilent 7250 GC/Q-TOF enabled the identification of additional components with increased confidence, as well as structure elucidation of the unknown compounds.Furthermore, using the novel ultra-low bleed Agilent J&amp;W DB-5Q GC column resulted in a significant decrease in background, which helps in the identification of late-eluting compounds.

News from LabRulezGCMS Library - Week 40, 2024

NIST, Wiley, and user-created EI mass spectral libraries are very powerful tools for the identification of organic compounds in complex mixtures by gas chromatography-mass spectrometry (GC-MS). &nbsp;This series of webinars will demonstrate the use of the NIST software suite including the NIST Search, AMDIS, and MS Interpreter for searching EI libraries. The series should be useful to a wide variety of research and developmental scientists involved in medical, environmental, industrial, forensic, and biological disciplines.<blockquote>The webinars demonstrate both Versions 3.0 (2023) and V2.4 of the NIST search. If you are using V3.0, start with Part 0. If you are using V2.4, start with Part I.</blockquote><h5>Today, we will look at:</h5><h3>Part V: Creating and Sharing User EI and MS/MS Libraries</h3><ul><li>Help Files for NIST Search</li><li>General Windows commands/functions</li><li>Creating a user library spectrum</li><li>Creating a user library spectrum: opening edit spectrum</li><li>Creating a user library spectrum: spectrum information window</li><li>Creating a user library spectrum: adding comments and synonyms</li><li>Creating a user library spectrum: using windows notepad and tags</li><li>Creating a user library spectrum: comment field display with user tags</li><li>Creating a user library spectrum: comment field display showing user tags</li><li>Tags included with Wiley libraries</li><li>Possible quality checks before adding spectra to user libraries</li><li>Addition of spectrum to user library or creating new library</li><li>(Re)Index Indices for structure, hybrid search and InChIKey for user library</li><li>NIST formatted user libraries at Eastman Chemical Company</li><li>Software essentials and approach</li><li>Excerpt of typical DOS script used in approach</li><li>Webinar References</li><li>Acknowledgements</li></ul><blockquote>Detailed Handouts including tables of content are available in the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ei_user_libraries_pt_v_2_cc2179c747/ei_user_libraries_pt_v-2.pdf">LabRulezGCMS library</a></blockquote><h4>Other parts of this series are focused on:</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=KppCCeYTWTU">Part 0: Changes in EI NIST23 Program (V3.0)</a> (video only)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/article/4438">Part I: Spectral Searches with NIST MS Search</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/article/4463">Part II: Structure Searches with MS Search and Using MS Interpreter</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/article/4494">Part III: AMDIS (NIST) for Processing EI Mass Spectral Data Files</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/article/4528">Part IV: Advanced NIST Hybrid Search of EI and MS/MS Spectra</a></li><li>Part V: Creating and Sharing User EI and MS/MS Libraries (this part)</li><li>Part VI: Creating and Using Retention Indices in NIST Software</li><li>Part VII: &nbsp;Tracking Complex Coelution with AMDIS and NIST Search</li></ul><h4>Higher quality videos can be downloaded here:</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1XGOnO6vwyJv6rPucIH-NgOTBdvH1jNDg/view?usp=sharing">Higher Quality Video Part 0</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/116Gzyh9nT4iDfJkac20K9aYarGvxpV2e/view?usp=sharing">Higher Quality Videos Pt. I-V Zipped</a></li></ul><h4>Other Webinar Resources:</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1EGlEubUOWiNy3Y3mQZWdoaUXsFKTNjjj/view?usp=sharing">Test Files Used In Part VII for Tracking Coelution in Complex Mixtures with AMDIS and NIST</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2023/04/27/nist2023-library-and-software-available-in-early-june/">New NIST23 Brochures and Purchasing</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2023/07/nist_2023_release_presentation.pdf">NIST23 ASMS Presentation Houston, TX</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://blog.sepscience.com/massspectrometry/nist-23">NIST 23 Separation Science Article by David Sparkman</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/08/20/most-current-user-manuals-for-nist-search-and-amdis/">NIST and AMDIS User Manuals</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/08/20/most-current-user-manuals-for-nist-search-and-amdis/">NIST Approach for Creating Libraries</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/08/20/most-current-user-manuals-for-nist-search-and-amdis/">Databases Listed in Version 3.0 (2023)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.acdlabs.com/resources/free-chemistry-software-apps/chemsketch-freeware/">ACD Free Software</a> (structure drawing program personal/academic use)</li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2023/04/free-drawing-program-mass-spec-calculator-professional/">Mass Spec Calculator Professional</a> (free structure drawing program)</li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2011/08/28/using-nist-search-program-with-data-processing-and-drawing-programs/">Using with Manufacturers Data Processing Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/10/11/excel-deltamass-table-for-hybrid-searches/">Delta Mass Table (Excel Format)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2023/05/deltamass_ei.pdf">Delta Mass Table (PDF format)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2023/01/25/unknown-identification-presentation-at-current-trends-in-seized-drugs-analysis-symposium/">Hybrid Search/ChemSpider/SciFinder for Illicit Drug Identifications</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2011/08/28/using-nist-search-program-with-data-processing-and-drawing-programs/">Importing Mass Spectra to NIST Search Program</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2021/01/31/nist-ms-interpreter/">MS_Interpreter Correlating Structure to Spectrum</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/09/21/nists-suggested-settings-for-amdis-filter-settings/">NIST Tutorials and Settings for AMDIS</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/09/20/using-example-file-and-spectra/">Example Files for Part III AMDIS Webinar</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/09/20/using-example-file-and-spectra/">Example Spectra/Structures in Library Format Parts I-V</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2020/09/wiley_usermanual.pdf">Wiley Library User Manual with Spectral Source Codes</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2011/08/28/using-nist-search-program-with-data-processing-and-drawing-programs/">Using with Manufacturers Data Processing Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2020/12/observations-on-spectra-in-mona-database.pdf">Components in Free MONA Libraries</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1kGdFVnYYmrE-n1trB6ngVRPrSgyHsEx7/view?usp=share_link">MONA Library in EI format</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1os21j4L87oUmQ8GhQcIvX4edk6014JJ5/view?usp=drive_link">MONA and Other Free Libraries, 60,829 EI Spectra</a> (see read_me in zip file)</li></ul>

Effective Use of EI Mass Spectral Databases in Unknown Identifications - Part V: Creating and Sharing User EI and MS/MS Libraries

Article

Application

Poster

Scientific article

Video

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

James Little/Mass Spec Interpretation Services

The Analytical Scientist

Agilent Technologies

Thermo Fisher Scientific

SelectScience

Join us on October 15th for a Live from the Lab for professionals from environmental and food testing labs.This hybrid event will be live streamed from our Customer Solution Center in Paris and explores the latest solutions and workflows to overcome challenges in environmental and food contaminant testing.You will have the opportunity to hear from Thermo Fisher Scientific and leading industry experts who will discuss and demonstrate new and advancing workflows to meet and exceed European regulations. We will delve into hot topics such as PFAS, pesticides, persistent organic compounds, and automation, providing you with valuable insights and strategies to tackle these issues effectively.Register now to secure your slot at one of the in-person events across Europe, or to join remotely from your desk.This is a unique opportunity to connect with industry professionals, so join us to explore, network, and collaborate on your future projects.<h3>Preliminary agenda</h3>10:15 Live streaming of this event to ‘satellite’ locations and online audience10:30 Introduction, Jeff Stubbs, Business Development Manager, Environment and Food Safety, Thermo Fisher Scientific10:55 Detecting PFAS in drinking water to meet regulations across Europe - New automated sample preparation high-resolution MS solution to achieve ppt detection limits, A Ganci, V Thibert and B Gauriat, Senior Product Application Specialists, Thermo Fisher Scientific11:35 Break12:05 New ready-to-go pesticide residue solution for faster, more confident results, Z Julian, Product Marketing, B Gauriat, and J Moriceau Senior Product Application Specialists Thermo Fisher Scientific12:45 Low-level contaminant testing in environmental water matrices – high-resolution GCMS approach to meet future regulations, John Quick, Principal Scientist, ALS Environmental Ltd13:15 Closing comments13:30 End of live streaming

Thermo Scientific: Solutions for environmental and food contaminant testing

Solutions for environmental and food contaminant testing

New and advancing workflows to meet and exceed European regulations.

<ul>
<li>Discuss what GC-MS/MS is and what applicaitons it is used for (Dioxins, POPs, etc.)
</li>
<li>Transition into an overview of APGC as a solution
</li>
<li>Discuss challenges or limitations of the current GC/MS/MS technology
</li>
<li>Share why using nitrogen as a carrier gas for GC/MS/MS analysis is optimal
</li>
</ul>
Webinar Learning Objectives:
<ul>
<li>Understanding GC-MS/MS and Its Applications:- Discuss the principles of gas chromatography-mass spectrometry (GC-MS/MS) and its role in analytical chemistry.- Explore specific applications of GC-MS/MS, including its use in detecting dioxins, persistent organic pollutants (POPs), and other environmental contaminants.
</li>
<li>Introduction to APGC (Atmospheric Pressure Gas Chromatography):-. Provide an overview of Atmospheric Pressure Gas Chromatography (APGC) as an alternative solution to traditional GC-MS/MS.- Highlight the advantages and unique features of APGC, such as improved sensitivity, reduced matrix effects, and enhanced selectivity.
</li>
<li>Challenges and Innovations in GC-MS/MS Technology:- Identify the current challenges and limitations faced by GC-MS/MS technology.- Discuss recent innovations and advancements aimed at overcoming these challenges.- Emphasize the importance of using nitrogen as a carrier gas for GC-MS/MS analysis, considering its inertness, availability, and compatibility with various detectors.
</li>
</ul>
<blockquote>
Prtesenter: Frank Dorman (Senior Principal Market Development Mgr, Waters Corporation)
</blockquote>
<blockquote>
Frank Dorman is currently Senior Principal Market Development Manager for Waters focusing on their global environmental business and, concurrently, a Resident Scholar in the Chemistry Department at Dartmouth College in Hanover, NH where he is active in teaching analytical chemistry to undergraduates and graduate students.
</blockquote>
<blockquote>
In his role at Waters, Frank manages the research-focused environmental market, external collaborations, and interfaces with R&amp;D for new product development. Prior to this, Frank was an Associate Professor in the Department of Biochemistry and Molecular Biology (BMB) sat Penn State University in University Park, PA. At Penn State, Frank served as a member of the Graduate Faculty in: Biochemistry, Microbiology and Molecular Biology (BMMB), Chemistry (CHEM), Biogeochemistry (BGC) and the Forensic Science Program (FRNSC) and the Center for Molecular Toxicology and Carcinogenesis. Franks scientific interests are in gas and liquid chromatography and fundamental characterization, instrumentation and column development, as well as mass spectrometry and atomic spectroscopy as applied to trace analysis in complex sample matrices.
</blockquote>
<blockquote>
Presenter: Sarah Dowd (Principal Mass Spectrometry Applications Specialist, Waters Corporation)
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<blockquote>
Sarah Dowd joined Waters as a mass spectrometry application specialist in 2015 after earning her PhD in analytical chemistry from the University of Illinois at Urbana Champaign.
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<blockquote>
In her eight years at Waters in the Americas application lab, Sarah has collaborated with many customers looking to expand the MS capabilities of their laboratories with Water&#39;s instruments and software. Specializing in analyses in food, environmental, and polymeric materials characterization, she has done extensive work looking at environmental contaminants with tandem quadrupole and high resolution mass spectrometers.
</blockquote>
<blockquote>
One of the hot topics for the past couple of years is the analysis of per- and polyfluoroalkyl substances (PFAS) and Sarah has collaborated with customers and other scientists within Waters to guide the next phase of PFAS testing with Waters mass spectrometry systems.
</blockquote>

Waters Corporation: APGC Roundtable: Unveiling the Pathways of GC-MS/MS Evolution

APGC Roundtable: Unveiling the Pathways of GC-MS/MS Evolution

Discuss what GC-MS/MS is and what applicaitons it is used for (Dioxins, POPs, etc.)

APGC Roundtable: Unveiling the Pathways of GC-MS/MS Evo

Join us for an exclusive one-day hybrid event, here we&#39;ll explore the latest trends and innovations in microplastics analysis. The morning session will be live-streamed and recorded, allowing virtual articipation for those unable to attend in person.
We are excited to invite you to a special hybrid event in partnership with i3 Membrane, where we will delve into the latest trends and innovations in microplastics analysis. Whether you join us in person or virtually, you’ll gain invaluable insights and hands-on experience.
Event also available in live stream
<h3>Agenda:</h3>
<ul>
<li>Morning session: Gain key insights into <a href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=microplastics+analysis">microplastics analysis</a>, as well as <a href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=PFAS">PFAS</a> and other environmental contaminants, through engaging presentations by top researchers and industry experts.
</li>
<li>Afternoon session: Participate in interactive workshops designed to enhance your practical skills in sample preparation. This provides a unique opportunity to master advanced techniques and methodologies under the guidance of professionals. Attend a live demo on the IR QCL-based <a href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=8700+LDIR">8700 LDIR</a>. Additionally, enjoy a guided laboratory tour offering an exclusive glimpse into the state-of-the-art facilities at the HEREON campus.
</li>
</ul>
<h5>9:15 a.m. - Welcome</h5>
<h5>9:20 a.m. - From Macroplastics to Mesoplastics: Challenges and Solutions</h5>
<ul>
<li>Dr. Marion Börger, Agilent Technologies,</li>
<li>Dr. Andreas Kerstan, Agilent Technologies</li>
</ul>
<h5>9:40 a.m. - i3 Membrane Session: Filter Membranes/Packaging - Jacobs</h5>
<ul>
<li>Kathrin Hahn, i3 Membrane</li>
</ul>
<h5>10:00 a.m. - Exploring Microplastic Sources and Distribution in Australian Soils</h5>
<ul>
<li>Subharthe Samandra, University of Melbourne</li>
</ul>
<h5>10:20 a.m. - Advancing Analysis: Eurofins&#39; Path to ISO 17025 Accreditation for Microplastics Testing</h5>
<ul>
<li>Julia Jäger, Eurofins</li>
</ul>
<h5>10:40 a.m. - Coffee Break</h5>
<h5>11:00 a.m. - Validation and Application of LDIR Imaging to Analyze Microplastics in Marine Samples</h5>
<ul>
<li>Lars Hildebrandt, Hereon</li>
</ul>
<h5>11:20 a.m. - Applying Multiple Analytical Techniques to Answer Open Questions About Offshore Wind</h5>
<ul>
<li>Alexa Zonderman, Hereon</li>
</ul>
<h5>11:40 a.m. - Sample-Based Subsampling Strategies to Analyze Large Quantities of Particles in LDIR</h5>
<ul>
<li>Manuel Andrade, University La Coruna</li>
</ul>
<h5>12:00 p.m. - Beyond the Surface: Spotlight on Plastic [Metal(loid)] Additive Leaching and Unseen Contaminants</h5>
<ul>
<li>Ole Klein, Hereon</li>
</ul>
<h5>12:20 p.m. - Microplastics back in food- Advantages of Thermal Desorption for a wide range of Samples</h5>
<h5>12:40 p.m. - Struggling with Solvent Effects During the Analysis of PFAS</h5>
<ul>
<li>Dr. Axel Ritter, Agilent Technologies</li>
</ul>
<h5>1:00 p.m. - Lunch Break</h5>
<h5>2:00 p.m. - An Analytical Toolbox to Unravel PFAS Source Fingerprints</h5>
<ul>
<li>Frank Menger, Hereon</li>
</ul>
<h5>2:20 p.m. - LDIR for Assessment of Microplastics in the VAMAS Ring Trial and Tissue in a Murine Infection Model</h5>
<ul>
<li>Christoph Krafft, IPHT</li>
</ul>
<h5>2:40 p.m. - Label-Free Infrared Spectroscopic Micro- and Nanoplastics Detection in Complex Matrices</h5>
<ul>
<li>Markus Brandstetter, Recendt</li>
</ul>
<h5>3:00 p.m. - Break in Dividing the Guests into Subgroups</h5>
<h5>3:10 p.m. - Lab Visits: Organic Lab, Microplastics Lab, Sample Prep, LDIR, and Other Techniques</h5>
<h5>4:50 p.m. - Wrap up</h5>
<h3>Meeting Information</h3>
<ul>
<li>Date: 29 October 2024
</li>
<li>Time: 9:00 a.m. to 4:50 p.m. CEST
</li>
<li>Location: GITZ GmbH, Max-Planck-Straße 2, 21502 Geesthacht, Germany 
</li>
<li>Meals included: Enjoy complimentary lunch and snacks during the event.
</li>
</ul>
Limited spots available! Hurry, to secure yours today.
<blockquote>
<a href="https://explore.agilent.com/microplameeting24#form">Secure your spot</a>
</blockquote>

Agilent Microplastics Meeting 2024

We'll explore the latest trends and innovations in microplastics analysis.

Get the most out of your mass spectrometer using the new DB-5Q and HP-5Q columns, which simplify mass spectral identification and deliver confident analysis of active compounds with unparalleled uptime of your instrument.As mass spectrometry continues to push the boundaries of sensitivity and speed, customers need a column that can do the same. The combination of our existing ultra inert (UI) and high-temperature (ht) features, combined with our new ultra low-bleed technology, enables our customers to reach lower levels of detection, accelerate sample throughput, improve data quality and reliability.<h4>Key learning objectives:</h4><ul><li>See what the new DB-5Q and HP-5Q columns can offer you by delivering ultra-low bleed, ultra-inert performance, and ultra-fast conditioning, combined with outstanding column durability.</li></ul><h4>Who should attend:</h4><ul><li>Anyone who uses gas chromatography – especially those using MS detection.</li></ul><blockquote>Presenter: Jan-Willem Marinissen (Technical Support Engineer, Agilent Technologies)Jan Willem Marinissen is a technical support engineer within the organization for the consumables and supplies division in the EMEA region.His working experience in the last decades has been in the field of chromatography in the broadest sense, that is, HPLC, sample prep and GC techniques.</blockquote>

Agilent Technologies: Get the Most Out of Your MS

Get the Most Out of Your MS

Get the most out of your mass spectrometer using the new DB-5Q and HP-5Q columns.

This webinar will guide you through optimizing your Q-TOF for superior data quality by selecting the most suitable tune mode for your samples.We will delve into various MS acquisition modes, including MS only, All Ions (QRAI), Auto MS/MS (directed MS/MS; targeted MS/MS), and PRM mode.Learn how to fine-tune method settings to enhance your data quality and achieve the best analytical results. Whether you’re a seasoned user or new to QTOF, this session will provide valuable insights to elevate your mass spectrometry.<blockquote>Presenter: &nbsp;Stefan Schaebler (Application Specialist LC/MS, Agilent Technologies)Stefan completed his PhD in Biology, specializing in LC-MS-based lipidomics and metabolomics. Following his doctoral studies, he joined Agilent Technologies as an LC/MS Application Specialist. In this role, Stefan focuses on small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</blockquote>

Agilent Technologies: MassHunter Masterclass Months

MassHunter Acquisition Q-TOF Part II – Advance Settings

Join us for an in-depth exploration of advanced settings in MassHunter Acquisition for Q-TOF systems.

We’ll explore how outlier setup can help you focus on samples and compounds that require your attention, ensuring accurate and reliable results.Additionally, you’ll learn how viewing compounds and calibration at a glance can expedite data review, making the process faster and more intuitive.Finally, we’ll demonstrate how easily you can summarize your results in comprehensive reports or export them to Excel, streamlining your workflow and enhancing productivity.Don’t miss this opportunity to enhance your data analysis skills with MassHunter Quant!<blockquote>Presenter: Peter Kornas (LC/MS Applikationsspezialist, Agilent Technologies)Peter Kornas has more than 10 years of experience in the development and validation of analytical methods for the determination of pesticides, mycotoxins and contaminants using LC/MS/MS. Before joining Agilent as an LC/MS application specialist in 2018, he worked as an analytical chemist in the food industry. During this time, he was responsible for the development and validation of analytical methods and worked in close coordination with Regulatory Affairs to ensure compliance with the legal requirements of the LC/MS method portfolio.</blockquote>

MassHunter Quant – A Fast and Easy Way from Data to Results

Join us and discover how quickly a quantitation method can be set up, enabling efficient data processing.

Join us for an insightful webinar where we will explore the critical aspects of differentiating good from bad data and how this distinction can significantly influence your results. From screening to quantification, discover the value of targeted data analysis workflows using non-targeted data with our innovative software and hardware.Find by Formula algorithm. Learn to identify the most suitable MS/MS approach for your experiments, initiate quantitation for your compounds of interest, and incorporate retention times (RTs) and MS/MS spectra into a custom database and library.This session is designed to enhance your understanding and application of Q-TOF data analysis, ensuring robust and reliable outcomes.<blockquote>Presenter: Hannah Florance (Agilent Technologies)Hannah has had multiple roles in the life sciences, starting as a protein chemist, before moving into proteomics and then metabolomics. A major part of her time working in academia involved running LC and GCMS core facilities supporting projects ranging from synthetic biology to cancer research. She is currently an LCMS applications specialist for Agilent. Presenter: Stefan Schaebler (Application Specialist LC/MS, Agilent Technologies)Stefan completed his PhD in Biology, specializing in LC-MS-based lipidomics and metabolomics. Following his doctoral studies, he joined Agilent Technologies as an LC/MS Application Specialist. In this role, Stefan focuses on small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</blockquote>

MassHunter Qual – The Solid Pillar in Q-TOF Data Analysis

We will explore the critical aspects of differentiating good from bad data and how this distinction can significantly influence your results.

Join our upcoming webinar on the MassHunter Quant Screener Tool to discover how to harness the power of quantitative analysis for effective screening and identification of potential suspect compounds.This session will provide in-depth guidance on creating methods from PCDL databases, evaluating result parameters, and generating straightforward summary reports. Additionally, learn how retention time (RT) prediction can enhance your screening process by significantly accelerating and simplifying large database searches.Don’t miss this opportunity to elevate your analytical capabilities!<blockquote>Presenter: &nbsp;Jonathan Spencer (Application Specialist, Agilent Technologies)Jonathan studied BSc Natural Sciences at the University of Nottingham and later went on to Sheffield Hallam University to study a MSc in Forensic Science.Following graduation, he spent 2 years as a Confirmatory Analyst in an anti-doping and forensic toxicology lab, before joining Agilent as an LC/MS Applications Scientist. At Agilent, he focuses on small molecule applications using LC/TQ and LC/Q-TOF in fields of like food, forensic and environmental analysis.</blockquote>

MassHunter Quant Screener Tool

Discover how to harness the power of quantitative analysis for effective screening and identification of potential suspect compounds. 

Join us on the hunt for the needle in the haystack!This session will delve into best practices for untargeted feature finding, focusing on achieving the optimal balance between sample coverage and processing speed using Profinder and the new MassHunter Explorer. We will explore techniques to differentiate between features and noise by applying the right filters for quality checking your data. Additionally, the webinar will cover essential aspects of compound identification, including database matching, formula generation, and structure elucidation.This is a must-attend event for anyone looking to enhance their analytical capabilities and streamline their data processing workflows.<blockquote>Presenter: &nbsp;Stefan Schaebler (Application Specialist LC/MS, Agilent Technologies)Stefan completed his PhD in Biology, specializing in LC-MS-based lipidomics and metabolomics. Following his doctoral studies, he joined Agilent Technologies as an LC/MS Application Specialist. In this role, Stefan focuses on small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</blockquote>

Finding the Needle in the Haystack Part I: From Complex Samples to Compounds of Interest

The best practices for untargeted feature finding, focusing on achieving the optimal balance between sample coverage and processing speed.

From Complex Samples to Compounds of Interest

Volatile profiling of food and beverages is crucial for understanding and enhancing their quality, safety, and consumer appeal. Analysing these volatiles presents several challenges due to the diversity of chemical classes, their varying concentrations, and the complex matrices involved, which can be problematic for conventional gas chromatography–mass spectrometry (GC–MS) approaches.Join Prof. Kieran Kilcawley, Principal Research Officer at Teagasc Food Research Centre and Adjunct Professor, University College Cork and Technological University Dublin, as he explores how innovative extraction and enrichment techniques, combined with state-of-the-art GC–MS analyses, can overcome these difficulties and deliver more detailed and accurate volatile profiles.Key learning objectives<ul><li>Understand the critical role volatile compounds play in shaping the flavor and overall quality of food and beverages</li><li>Learn about the latest techniques for the sensitive extraction and analysis of aroma-active compounds, including high-capacity sorptive extraction and comprehensive two-dimensional gas chromatography (GCxGC).</li><li>Explore practical applications through case studies, including volatile profiling of whiskey, analysis of fatty acids in dairy products, and evaluating the impact of cooking temperature on the volatile profile of beef</li></ul>Who should attend?<ul><li>Food scientists who want to understand more about profiling, odour perception, sensory evaluation, and food authenticity analysis.</li><li>R&amp;D food scientists and analytical scientists who want to enhance their understanding of analysing complex samples.</li><li>GC(–MS) users eager to hear about the latest instrument developments.</li></ul>Certificate of attendanceAll webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.<blockquote>Presenter: Prof. Kieran Kilcawley (Principal Research Officer, Teagasc Food Research Centre and Adjunct Professor, University College Cork and Technological University Dublin)Prof. Kieran Kilcawley oversees the flavor chemistry facility at Teagasc, where he conducts extensive research on flavors in various foods and beverages. He became an Adjunct Professor in the Department of Food and Nutritional Sciences at University College Cork in 2020 and in the School of Food Science and Environmental Health at the Technological University Dublin in 2024. His expertise encompasses advanced gas chromatography and mass spectrometry, including olfactometry, as well as aroma extraction, method development and validation, data processing, and chemometrics.Moderator: Carrie Haslam (Associate Editor, SelectScience)</blockquote>

SelectScience: Investigating the impact of volatile compounds on the flavor profiles of foods and drinks

Investigating the impact of volatile compounds on the flavor profiles of foods and drinks

Innovative extraction and enrichment techniques with GC–MS analyses for detailed and accurate volatile profiles.

GCMS webinars focusing on GC/MS | LabRulez GCMS