Broadband Laser-Based Infrared Detector for Gas Chromatography

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 30th September 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring to you applications by Agilent Technologies, Waters Corporation, and Thermo Fisher Scientific, and a poster from <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/companies/296">ASMS</a> by Shimadzu!<h4>1. Shimadzu: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/TP_093_Analysis_of_PFAS_in_Water_Final_05292024_8fa9fcb27d.pdf">Analysis of Volatile PFAS in Water Using Head-Space Solid Phase Microextraction- Gas Chromatography/Mass Spectrometry (HS-SPME GC/MS)</a></h4><ul><li>Poster / <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/companies/296">ASMS</a>&nbsp;</li></ul>Introduction&nbsp;Per- and Polyfluoroalkyl Substances (PFAS) are environmental pollutants with recognized health and environmental concerns due to their probable toxicity, persistence, and ubiquitousness throughout the environment, and consumer and industrial products. PFAS encompass a large family of chemicals with varying physicochemical properties. These properties not only affect their toxicity and environmental fate, but also complicates chemical analysis.In this work, a Head-Space Solid Phase Microextraction-Gas Chromatography/Mass Spectrometry (HS-SPME GCMS) analytical method was developed to analyze six classes of volatile PFAS in water. This HS-SPME method presents the advantage of simplifying sample extraction and handling for the analysis of volatile PFAS in water, hence, minimizing operational costs, potential errors, and risk of sample-cross contamination.ConclusionThis study demonstrated the use of a Shimadzu GC/MS-QP2020 NX single quadrupole instrument configured with the AOC-6000 Plus multifunctional autosampler and an automated head space solid phase microextraction unit for measurement of volatile PFAS compounds in water. Linear calibration curves were obtained for all compounds (R 2 ≥ 0.993 and RF %RSD &lt; 20 %). The HS-SPME GC/MS-QP2020 NX method demonstrated qualitative and quantitative capability of analyzing PFAS compounds.<h4>2. Thermo Fisher Scientific: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_003028_gc_ms_isq_epa_vocs_an003028_na_en_7646797ef5.pdf">Analysis of volatile organic compounds in drinking water according to U.S. EPA Method 524.4</a></h4><ul><li>Application</li></ul>GoalDemonstration of an analytical method that meets the requirements outlined in U.S. EPA Method 524.4 for the quantitation of volatile organic compounds (VOCs) in drinking water, using the Teledyne LABS Tekmar Lumin Purge and Trap (P&amp;T) concentrator paired with the AQUATek LVA autosampler system along with a Thermo Scientific™ ISQ™ 7610 MS system coupled with a Thermo Scientific™ TRACE™ 1610 gas chromatograph (GC) and Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS). Target analyte linearity, method detection limit (MDL), minimum report level (MRL), and mid-point precision and accuracy were assessed to evaluate method performance.Keywords: EPA, U.S. EPA 524.4, VOCs, phthalates, trace analysis, gas chromatography, single quadrupole mass spectrometry, selected ion monitoring, sensitivity, GRO, THM, volatiles, environmental lab, environmental sample analysis, analytical testing laboratories, ISQ 7610 MS, TRACE 1610 GC, GC-MS.IntroductionVolatile organic compounds (VOCs) are man-made contaminants in various products that pose environmental and public health risks. These compounds are regulated in drinking water, and laboratories follow regulations including U.S. EPA Method 524.2.1 A previous application note described U.S. EPA Method 524.2,2,3 which is the most common method for VOC water testing in the USA. U.S. EPA Method 524.4 is an updated method that allows for nitrogen to be used as the purge gas, thus reducing helium consumption, and is now being more widely used. Targeting 75 VOCs, this method differs by offering more method parameter flexibility but stricter quality control, including the stringent calculation of the minimum reporting level for evaluating calibration checks.Implementing U.S. EPA Method 524.4 can present multiple challenges for laboratories. Striking a balance between optimized method conditions and meeting the acceptance criteria, like detection limit requirements for various compound concentrations, is pivotal. Another major hurdle is managing the water matrix to minimize GC-MS system water introduction, which could lead to detrimental effects and delay sample reporting, thereby increasing public safety risks. Ultimately, maintaining consistency in test results to avoid sample reanalysis is crucial. Another factor for laboratories to consider is the fluctuating cost of helium, which is the analytical gas of choice for this analysis. Reducing the use of helium—a limited resource—will enable the laboratory to reduce operational costs and increase profitability.The following evaluation describes the use of the ISQ 7610 GC-MS system coupled with a TRACE 1610 GC with the Thermo Scientific™ HeSaver-H2Safer™ split/splitless injector and Teledyne LABS Tekmar Lumin P&amp;T concentrator paired with the AQUATek LVA autosampler for U.S. EPA Method 524.4.ConclusionThe combined solution of the TRACE 1610 GC coupled with the ISQ 7610 system and the Tekmar Lumin P&amp;T concentrator with the AQUATek LVA autosampler system successfully addresses the challenges of VOC analysis and provides a robust, sensitive solution needed for ensuring maximized sample throughput and regulatory method compliance for U.S. EPA Method 524.4.<ul><li>Excellent linearity for all compounds was demonstrated with the linear regression (r²≥0.995) of the calibration response factors passing all method requirements.</li><li>MDL and precision for seven 0.5 ppb standards showed no interference from excessive water and produced very reproducible results.</li><li>The precision for n=30 samples over 245 injections displayed &lt;30% RSD for all compounds as the method requires and an average recovery of 91%.</li><li>Utilizing HeSaver-H2Safer technology reduced helium consumption for the method by 4 times, which provides a significant cost savings.</li></ul><h4>3. Waters Corporation: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720008298_en_db4158391c.pdf">Extractables Analysis of Nasal Spray Devices Using Gas Chromatography and High- Resolution Mass Spectrometry With Soft Ionization</a></h4><ul><li>Application</li></ul>AbstractDue to concern about the safety of components from plastic, it is crucial to screen for and identify potential extractables and leachables (E&amp;L) in pharmaceutical packaging and medical devices. For volatile, and semi-volatile compounds, gas chromatography-mass spectrometry (GC-MS) with electron ionization (EI) is typically used. Compounds are determined using scientific libraries; however, where compounds are not listed or where the sensitivity of EI-MS is not sufficient, the identification process becomes challenging.Here, we describe an E&amp;L screening experiment using gas chromatography and a quadrupole time of flight high-resolution mass spectrometer (QToF-HRMS) with atmospheric pressure gas chromatography (APGC) for soft ionization. A data independent acquisition (DIA) strategy is utilized to aid screening and elucidation which are combined in a screening software solution.Benefits<ul><li>GC-QToF MS with APGC as an orthogonal technique to LC-QToF-MS allows for comprehensive compound coverage with increased sensitivity compared to typical EI techniques</li><li>The UNIFI™ application within the waters_connect™ platform provides customized workflows to simplify screening and structural elucidation in complex datasets</li><li>The Xevo™ G3 QTof Mass Spectrometer enables confident identification of E&amp;L components in complex matrices through novel ion optics and detection system which maximize transmission</li><li>Soft ionization using the APGC™ source allows for the detection of molecular ions from which elemental compositions can be derived to aid compound identification and confirmation&nbsp;</li><li>MSE, a data independent acquisition, increases confidence in identifications when screening against a library and provides additional information to aid structural elucidation</li></ul>Conclusion&nbsp;When undertaking E&amp;L screening analyses it is important to use a range of analytical techniques to account for different compound chemistries. GC-QToF MS with APGC as an orthogonal technique to LC-QToF-MS allowed for comprehensive compound coverage with increased sensitivity compared to typical EI techniques. Due to the soft ionization of APGC, the intact molecular ion is often present in the spectra. This combined with a data independent acquisition, MSE mode, utilizes full spectral acquisition of the accurate mass information of both precursor and fragment ions.This approach boosts confidence in component identifications when screening against an MS/MS library, while minimizing false positives. For instance, in the LC-QToF-MS there were just under 40 potential compounds matches in sample E48 after considering factors such as retention time match, mass accuracy below 3 ppm, and the presence of at least one fragment ion. A further 38 compound matches in sample E48 were tentatively identified using GC-QToF MS with APGC, with mass accuracy below 3 ppm, and the presence of at least one fragment ion.MSE data also aids in the structural elucidation of unknown substances by utilizing accurate mass and corresponding fragment ions, facilitating comprehensive characterization. This data increases confidence in identifications of components and assists with structural elucidation of unknowns to ultimately aid full characterization. For example an unknown with protonated m/z 284.2703 was tentatively identified as a N-(2-(1-piperazinyl)ethyl)decanamide (mass error 2.33 ppm) by the software.For the extractables analysis of nasal sprays the UNIFI application within the waters_connect platform provided SST benchmarking, screening against a library, summary plots to identify trends, filtering of AET levels, binary compare mode to isolate relevant unknowns, and a Discovery Tool for elucidation of unknowns.<h4>4. Agilent Technologies: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_voc_rubber_gasket_extracts_gc_msd_5994_7777en_agilent_6a0a6bf7d0.pdf">Analysis of Volatile Compounds Identified in Rubber Gasket Extracts Using GC/MSD and High-Resolution GC/Q-TOF</a></h4><ul><li>Application</li></ul>AbstractChemicals that are part of polymeric container closure systems (CCS) and drug delivery systems have the potential to migrate into drug products during manufacturing, storage, transport, and delivery, and must be identified in the final products to ensure their safety.This application note presents a rubber gasket extractables study using a unit mass resolution gas chromatography/mass selective detector (GC/MSD) and a high-resolution gas chromatography/quadrupole time-of-flight (GC/Q-TOF) mass spectrometer to establish a process for identifying GC-amenable extractables and leachable (E&amp;L) compounds.IntroductionElastomeric gaskets, plungers, and O-rings are common sources of leachable compounds in the manufacturing, storage, and delivery of drug products. E&amp;Ls derived from elastomeric components may impact the stability and efficacy of small and large molecule drug products1, and therefore need to be characterized thoroughly. Exposure to some E&amp;L chemicals, such as phthalates and nitrosamines, even at low levels, may cause safety concerns.2 Chemicals derived from the elastomer manufacturing process typically include accelerators, activators, antioxidants, fillers, plasticizers (including phthalates), mold release agents, and other additives3 that may leach into the final product. Some additives present in elastomer packaging materials may also contain polycyclic aromatic hydrocarbons (PAHs)4 and aliphatic hydrocarbons.GC/MS is a commonly used technique for analyzing volatile and semivolatile organic compounds in the E&amp;L space. This study demonstrates the capabilities of GC/MSD to identify GC-amenable compounds present in a solvent extract of a rubber gasket by leveraging chromatographic deconvolution in combination with retention index (RI)-based filtering. Adding a high-resolution accurate mass GC/Q-TOF into the E&amp;L workflow provided a higher number of identified chemicals. It also increased confidence in compound identification and enabled structure elucidation of unknown compounds.The study was performed in the Network Workstation configuration using Agilent OpenLab Electronic Content Management (ECM) XT as the data repository. This configuration enabled tools that facilitate compliance with various national and EU electronic record regulations, including audit trails, user authentication, role-based permission controls, and remote data storage.5ConclusionThe GC/MSD is an effective and accessible tool for the analysis of volatile and semivolatile compounds in complex E&amp;L extracts. The established workflow includes deconvolution and an RI-based library search with the data acquisition performed in a compliant environment.The high-resolution Agilent 7250 GC/Q-TOF enabled the identification of additional components with increased confidence, as well as structure elucidation of the unknown compounds.Furthermore, using the novel ultra-low bleed Agilent J&amp;W DB-5Q GC column resulted in a significant decrease in background, which helps in the identification of late-eluting compounds.

News from LabRulezGCMS Library - Week 40, 2024

NIST, Wiley, and user-created EI mass spectral libraries are very powerful tools for the identification of organic compounds in complex mixtures by gas chromatography-mass spectrometry (GC-MS). &nbsp;This series of webinars will demonstrate the use of the NIST software suite including the NIST Search, AMDIS, and MS Interpreter for searching EI libraries. The series should be useful to a wide variety of research and developmental scientists involved in medical, environmental, industrial, forensic, and biological disciplines.<blockquote>The webinars demonstrate both Versions 3.0 (2023) and V2.4 of the NIST search. If you are using V3.0, start with Part 0. If you are using V2.4, start with Part I.</blockquote><h5>Today, we will look at:</h5><h3>Part V: Creating and Sharing User EI and MS/MS Libraries</h3><ul><li>Help Files for NIST Search</li><li>General Windows commands/functions</li><li>Creating a user library spectrum</li><li>Creating a user library spectrum: opening edit spectrum</li><li>Creating a user library spectrum: spectrum information window</li><li>Creating a user library spectrum: adding comments and synonyms</li><li>Creating a user library spectrum: using windows notepad and tags</li><li>Creating a user library spectrum: comment field display with user tags</li><li>Creating a user library spectrum: comment field display showing user tags</li><li>Tags included with Wiley libraries</li><li>Possible quality checks before adding spectra to user libraries</li><li>Addition of spectrum to user library or creating new library</li><li>(Re)Index Indices for structure, hybrid search and InChIKey for user library</li><li>NIST formatted user libraries at Eastman Chemical Company</li><li>Software essentials and approach</li><li>Excerpt of typical DOS script used in approach</li><li>Webinar References</li><li>Acknowledgements</li></ul><blockquote>Detailed Handouts including tables of content are available in the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ei_user_libraries_pt_v_2_cc2179c747/ei_user_libraries_pt_v-2.pdf">LabRulezGCMS library</a></blockquote><h4>Other parts of this series are focused on:</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=KppCCeYTWTU">Part 0: Changes in EI NIST23 Program (V3.0)</a> (video only)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/article/4438">Part I: Spectral Searches with NIST MS Search</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/article/4463">Part II: Structure Searches with MS Search and Using MS Interpreter</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/article/4494">Part III: AMDIS (NIST) for Processing EI Mass Spectral Data Files</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/article/4528">Part IV: Advanced NIST Hybrid Search of EI and MS/MS Spectra</a></li><li>Part V: Creating and Sharing User EI and MS/MS Libraries (this part)</li><li>Part VI: Creating and Using Retention Indices in NIST Software</li><li>Part VII: &nbsp;Tracking Complex Coelution with AMDIS and NIST Search</li></ul><h4>Higher quality videos can be downloaded here:</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1XGOnO6vwyJv6rPucIH-NgOTBdvH1jNDg/view?usp=sharing">Higher Quality Video Part 0</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/116Gzyh9nT4iDfJkac20K9aYarGvxpV2e/view?usp=sharing">Higher Quality Videos Pt. I-V Zipped</a></li></ul><h4>Other Webinar Resources:</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1EGlEubUOWiNy3Y3mQZWdoaUXsFKTNjjj/view?usp=sharing">Test Files Used In Part VII for Tracking Coelution in Complex Mixtures with AMDIS and NIST</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2023/04/27/nist2023-library-and-software-available-in-early-june/">New NIST23 Brochures and Purchasing</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2023/07/nist_2023_release_presentation.pdf">NIST23 ASMS Presentation Houston, TX</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://blog.sepscience.com/massspectrometry/nist-23">NIST 23 Separation Science Article by David Sparkman</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/08/20/most-current-user-manuals-for-nist-search-and-amdis/">NIST and AMDIS User Manuals</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/08/20/most-current-user-manuals-for-nist-search-and-amdis/">NIST Approach for Creating Libraries</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/08/20/most-current-user-manuals-for-nist-search-and-amdis/">Databases Listed in Version 3.0 (2023)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.acdlabs.com/resources/free-chemistry-software-apps/chemsketch-freeware/">ACD Free Software</a> (structure drawing program personal/academic use)</li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2023/04/free-drawing-program-mass-spec-calculator-professional/">Mass Spec Calculator Professional</a> (free structure drawing program)</li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2011/08/28/using-nist-search-program-with-data-processing-and-drawing-programs/">Using with Manufacturers Data Processing Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/10/11/excel-deltamass-table-for-hybrid-searches/">Delta Mass Table (Excel Format)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2023/05/deltamass_ei.pdf">Delta Mass Table (PDF format)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2023/01/25/unknown-identification-presentation-at-current-trends-in-seized-drugs-analysis-symposium/">Hybrid Search/ChemSpider/SciFinder for Illicit Drug Identifications</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2011/08/28/using-nist-search-program-with-data-processing-and-drawing-programs/">Importing Mass Spectra to NIST Search Program</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2021/01/31/nist-ms-interpreter/">MS_Interpreter Correlating Structure to Spectrum</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/09/21/nists-suggested-settings-for-amdis-filter-settings/">NIST Tutorials and Settings for AMDIS</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/09/20/using-example-file-and-spectra/">Example Files for Part III AMDIS Webinar</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/09/20/using-example-file-and-spectra/">Example Spectra/Structures in Library Format Parts I-V</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2020/09/wiley_usermanual.pdf">Wiley Library User Manual with Spectral Source Codes</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2011/08/28/using-nist-search-program-with-data-processing-and-drawing-programs/">Using with Manufacturers Data Processing Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2020/12/observations-on-spectra-in-mona-database.pdf">Components in Free MONA Libraries</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1kGdFVnYYmrE-n1trB6ngVRPrSgyHsEx7/view?usp=share_link">MONA Library in EI format</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1os21j4L87oUmQ8GhQcIvX4edk6014JJ5/view?usp=drive_link">MONA and Other Free Libraries, 60,829 EI Spectra</a> (see read_me in zip file)</li></ul>

Effective Use of EI Mass Spectral Databases in Unknown Identifications - Part V: Creating and Sharing User EI and MS/MS Libraries

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Application

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Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

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My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

James Little/Mass Spec Interpretation Services

Anton Paar

Agilent Technologies

Bruker

Phenomenex

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Quantum Analytics

SelectScience

Waters Corporation

Leaks are problematic for any operation that uses gas tubing and fittings. Even small gas leaks can lead to safety issues, reduced productivity, and increased costs.
<ul>
<li>Leaks can introduce water and air into the gas flow and tubing.
</li>
<li>Persistent, unidentified leaks can saturate gas filters faster than expected and cause decreased sensitivity and/or elevated baselines in instrument detectors, such as GC, GC/MS, ICP-MS, or ICP-OES.
</li>
<li>Leaks can also lead to shortened lifetimes of some consumables, especially in GC systems.
</li>
<li>Further, leaks allow the gas to flow out of the fitting and can cause loss of production and revenue if trying to produce or collect and supply the gas.
</li>
</ul>
Also, if gas is being consumed at a higher rate than expected because of leakage, gas supply costs will increase. Checking for and eliminating leaks from the gas source to the terminus can reduce safety concerns and reduce costs through decreased use of cylinders or fewer refills by the gas supply company.
Join us as we explore how to identify signs of leaks, address any existing leaks, and prevent future leaks.
<blockquote>
Presenter: Alex Ucci (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
In his current position at Agilent, Alex provides application assistance and technical support for sample preparation products as well as GC and LC consumables. Before he joined Agilent in 2014, Alex was a graduate student at the Pennsylvania State University researching the morphology and surface properties of aerosol particles using a wide variety of analytical techniques. He has an MS degree in chemistry.
</blockquote>

Agilent Technologies: Sealing the Deal: Strategies for Leak-Free GC

Sealing the Deal: Strategies for Leak-Free GC

We explore how to identify signs of leaks, address any existing leaks, and prevent future leaks.

Join us on October 15th for a Live from the Lab for professionals from environmental and food testing labs.This hybrid event will be live streamed from our Customer Solution Center in Paris and explores the latest solutions and workflows to overcome challenges in environmental and food contaminant testing.You will have the opportunity to hear from Thermo Fisher Scientific and leading industry experts who will discuss and demonstrate new and advancing workflows to meet and exceed European regulations. We will delve into hot topics such as PFAS, pesticides, persistent organic compounds, and automation, providing you with valuable insights and strategies to tackle these issues effectively.Register now to secure your slot at one of the in-person events across Europe, or to join remotely from your desk.This is a unique opportunity to connect with industry professionals, so join us to explore, network, and collaborate on your future projects.<h3>Preliminary agenda</h3>10:15 Live streaming of this event to ‘satellite’ locations and online audience10:30 Introduction, Jeff Stubbs, Business Development Manager, Environment and Food Safety, Thermo Fisher Scientific10:55 Detecting PFAS in drinking water to meet regulations across Europe - New automated sample preparation high-resolution MS solution to achieve ppt detection limits, A Ganci, V Thibert and B Gauriat, Senior Product Application Specialists, Thermo Fisher Scientific11:35 Break12:05 New ready-to-go pesticide residue solution for faster, more confident results, Z Julian, Product Marketing, B Gauriat, and J Moriceau Senior Product Application Specialists Thermo Fisher Scientific12:45 Low-level contaminant testing in environmental water matrices – high-resolution GCMS approach to meet future regulations, John Quick, Principal Scientist, ALS Environmental Ltd13:15 Closing comments13:30 End of live streaming

Thermo Scientific: Solutions for environmental and food contaminant testing

Solutions for environmental and food contaminant testing

New and advancing workflows to meet and exceed European regulations.

Get the most out of your mass spectrometer using the new DB-5Q and HP-5Q columns, which simplify mass spectral identification and deliver confident analysis of active compounds with unparalleled uptime of your instrument.As mass spectrometry continues to push the boundaries of sensitivity and speed, customers need a column that can do the same. The combination of our existing ultra inert (UI) and high-temperature (ht) features, combined with our new ultra low-bleed technology, enables our customers to reach lower levels of detection, accelerate sample throughput, improve data quality and reliability.<h4>Key learning objectives:</h4><ul><li>See what the new DB-5Q and HP-5Q columns can offer you by delivering ultra-low bleed, ultra-inert performance, and ultra-fast conditioning, combined with outstanding column durability.</li></ul><h4>Who should attend:</h4><ul><li>Anyone who uses gas chromatography – especially those using MS detection.</li></ul><blockquote>Presenter: Jan-Willem Marinissen (Technical Support Engineer, Agilent Technologies)Jan Willem Marinissen is a technical support engineer within the organization for the consumables and supplies division in the EMEA region.His working experience in the last decades has been in the field of chromatography in the broadest sense, that is, HPLC, sample prep and GC techniques.</blockquote>

Agilent Technologies: Get the Most Out of Your MS

Get the Most Out of Your MS

Get the most out of your mass spectrometer using the new DB-5Q and HP-5Q columns.

<h4>Key Learning Points:</h4><ul><li>Identify the common challenges associated with solid phase extraction methods &nbsp;</li><li>Understand and troubleshoot the recovery, contamination and reproducibility issues &nbsp;</li><li>Learn how to find and apply solutions to develop robust and reproducible extraction methods for their sample preparation needs</li></ul><h4>Who Should Attend:</h4><ul><li>Any scientists who wants to learn about solid phase extraction and it’s associated challenges, common troubleshooting steps and solutions to develop robust and reproducible extraction methods for their sample preparation needs</li></ul><blockquote>Presnter: Namrata Saxena (Technical Manager, Phenomenex)Namrata is the Technical Manager for the Asia-Pacific region in Phenomenex and is based in Sydney, Australia. As a member of the global technical team, she is responsible for assisting external customers as well as internal marketing and sales teams of Phenomenex for multifarious technical queries. She specifically support company’s bio-products portfolio through external and internal seminars/webinars, trainings and also contribute in biologics related technical content creation.Before joining Phenomenex she had worked as a Product Specialist and spent several years in stationary phase chemistry, column manufacturing and method development groups in a German company Bischoff Chromatography GmbH.Namrata has a post graduate degree with specialization in Analytical Chemistry. Her competence and focus lies in biotherapeutics characterization through liquid chromatography, antibodies and oligonucleotide chemistry, gene therapy and new bio-therapeutic modalities.</blockquote>

Phenomenex: Solid Phase Extraction Troubleshooting Tips and Tricks

Solid Phase Extraction Troubleshooting Tips and Tricks

Identify the common challenges associated with solid phase extraction methods.

This webinar will guide you through optimizing your Q-TOF for superior data quality by selecting the most suitable tune mode for your samples.We will delve into various MS acquisition modes, including MS only, All Ions (QRAI), Auto MS/MS (directed MS/MS; targeted MS/MS), and PRM mode.Learn how to fine-tune method settings to enhance your data quality and achieve the best analytical results. Whether you’re a seasoned user or new to QTOF, this session will provide valuable insights to elevate your mass spectrometry.<blockquote>Presenter: &nbsp;Stefan Schaebler (Application Specialist LC/MS, Agilent Technologies)Stefan completed his PhD in Biology, specializing in LC-MS-based lipidomics and metabolomics. Following his doctoral studies, he joined Agilent Technologies as an LC/MS Application Specialist. In this role, Stefan focuses on small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</blockquote>

Agilent Technologies: MassHunter Masterclass Months

MassHunter Acquisition Q-TOF Part II – Advance Settings

Join us for an in-depth exploration of advanced settings in MassHunter Acquisition for Q-TOF systems.

Volatile profiling of food and beverages is crucial for understanding and enhancing their quality, safety, and consumer appeal. Analysing these volatiles presents several challenges due to the diversity of chemical classes, their varying concentrations, and the complex matrices involved, which can be problematic for conventional gas chromatography–mass spectrometry (GC–MS) approaches.Join Prof. Kieran Kilcawley, Principal Research Officer at Teagasc Food Research Centre and Adjunct Professor, University College Cork and Technological University Dublin, as he explores how innovative extraction and enrichment techniques, combined with state-of-the-art GC–MS analyses, can overcome these difficulties and deliver more detailed and accurate volatile profiles.Key learning objectives<ul><li>Understand the critical role volatile compounds play in shaping the flavor and overall quality of food and beverages</li><li>Learn about the latest techniques for the sensitive extraction and analysis of aroma-active compounds, including high-capacity sorptive extraction and comprehensive two-dimensional gas chromatography (GCxGC).</li><li>Explore practical applications through case studies, including volatile profiling of whiskey, analysis of fatty acids in dairy products, and evaluating the impact of cooking temperature on the volatile profile of beef</li></ul>Who should attend?<ul><li>Food scientists who want to understand more about profiling, odour perception, sensory evaluation, and food authenticity analysis.</li><li>R&amp;D food scientists and analytical scientists who want to enhance their understanding of analysing complex samples.</li><li>GC(–MS) users eager to hear about the latest instrument developments.</li></ul>Certificate of attendanceAll webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.<blockquote>Presenter: Prof. Kieran Kilcawley (Principal Research Officer, Teagasc Food Research Centre and Adjunct Professor, University College Cork and Technological University Dublin)Prof. Kieran Kilcawley oversees the flavor chemistry facility at Teagasc, where he conducts extensive research on flavors in various foods and beverages. He became an Adjunct Professor in the Department of Food and Nutritional Sciences at University College Cork in 2020 and in the School of Food Science and Environmental Health at the Technological University Dublin in 2024. His expertise encompasses advanced gas chromatography and mass spectrometry, including olfactometry, as well as aroma extraction, method development and validation, data processing, and chemometrics.Moderator: Carrie Haslam (Associate Editor, SelectScience)</blockquote>

SelectScience: Investigating the impact of volatile compounds on the flavor profiles of foods and drinks

Investigating the impact of volatile compounds on the flavor profiles of foods and drinks

Innovative extraction and enrichment techniques with GC–MS analyses for detailed and accurate volatile profiles.

Impact of volatile compounds on the flavor profiles

This is the second in our three-part Ask Me Anything webinar series on one of the most frequently asked about topics - processing data. The Components tab in the Processing Method displays many fields of information, giving you options about peak identification, calibration, reference peaks, and fields used in conjunction with custom fields.In Part 2 of this series, we will discuss:<ul><li>Peak identification</li><li>Calibration options including external and internal calibration</li><li>Reference Peaks for peak identification and calibration</li><li>Impurity fields</li><li>CCompRef1, 2, 3, and CConst1-7</li><li>Fields related to chemical structures</li></ul>Please join us for a lively discussion as we explore this topic. As always, please bring your questions for this exclusive opportunity to ask our experts anything about Empower Software.<blockquote>Presenter: Neil Lander (Principal Product Manager, Informatics, Waters Corporation)Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager focusing on Informatics solutions. He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.</blockquote>

Waters Corporation: Empower Tips: Ask Me Anything About Processing Data - Part 2

Empower Tips: Ask Me Anything About Processing Data - Part 2

This is the second in our three-part Ask Me Anything webinar series on one of the most frequently asked about topics - processing data.

Empower Tips: Ask Me Anything About Processing Data

We kindly invite you to join us for this live webinar: An Introduction to Nanoscale Infrared Spectroscopy and Imaging with Photothermal AFM-IR. Infrared (IR) spectroscopy is a commonly used characterization technique for organic materials and many inorganic compounds and crystals. While powerful, it is limited by the diffraction limit to resolution on the order of several microns, and the lateral resolution is strongly dependent on the wavelength. Photothermal AFM-IR&nbsp;is a novel technique which offers IR spectroscopy and imaging on materials with a lateral resolution 1000x better than traditional FTIR and &lt;1 nm detection sensitivity with model-free interpretation. AFM-IR achieves this by using an AFM probe as the detector of photothermal expansion. This opens a variety of applications on both organic and inorganic materials where nanometer sensitivity and resolution are key.<div> In this webinar we will:</div><ul><li>Introduce the photothermal AFM-IR technique</li><li>Explore the surprisingly simple mechanism underlying the technique</li><li>Highlight a few of its many broad applications</li><li>Offer a demonstration of photothermal AFM-IR on the Dimension IconIR system</li></ul><blockquote>Presenter: Peter De Wolf, Ph.D., (Director of Technology &amp; Application Development)Peter De Wolf is director for AFM technology &amp; application development at Bruker Nano Surfaces, covering all applications related to Scanning Probe Microscopy (SPM). He obtained his PhD from IMEC, Belgium on the development of new SPM methods for 2D carrier profiling in semiconductors and has more than 25 years of experience on SPM. He is the author and co-author of over 30 publications related to electrical characterization using SPM. He also owns several SPM patents, and developed several new SPM modes for electrical characterization.Presenter: Cassandra Phillips, Ph.D. (Application Scientist, Bruker)Cassandra did her Ph.D. at the University of Toronto exploring the photophysics of boron nitride nanotubes using scattering scanning nearfield optical microscopy (s-SNOM) and computational models. She has been working at Bruker Nano Surfaces and Metrology since September 2019 as an Applications Scientist focusing on nanoscale IR spectro-microscopy and other correlated imaging techniques realized with atomic force microscopy.Presenter: Dr. Qichi Hu, (Senior Applications Scientist )Qichi is currently a Senior Staff Applications Scientist at Bruker Nano. He received a bachelor’s degree from Peking University and Ph.D. from University of British Columbia. He then did postdocs in U.S. university and national labs. Qichi has been working on nanoIR development and applications for over a decade, at Anasys and now at Bruker.</blockquote>

Bruker: Introduction to Nanoscale Infrared Spectroscopy and Imaging with Photothermal AFM-IR

Introduction to Nanoscale Infrared Spectroscopy and Imaging with Photothermal AFM-IR

An Introduction to Nanoscale Infrared Spectroscopy and Imaging with Photothermal AFM-IR.

Nanoscale IR Spectroscopy / Imaging with Photothermal AFM-IR

Unlock a new level of precision and ease in your industrial operations with our upcoming webinar on FTIR gas analysis. Traditionally, gas analyzers demanded extensive expertise and complex setups, but Bruker has revolutionized this with cutting-edge technology that simplifies and accelerates the process of analyzing gaseous mixtures.Discover how innovative FTIR-based gas analysis systems, the Bruker MATRIX II-MG Series and the OMEGA 5 Gas Analysis System offer unparalleled dynamic range and effortless integration into any industrial setting. User-friendly interface and intuitive software make around-the-clock monitoring a breeze, providing real-time alerts when critical thresholds are missed. From power plants to production facilities, Bruker’s FTIR-based gas analyzers fit seamlessly into your existing workflows with remote control capabilities designed to enhance your operational efficiency.Join us to explore how state-of-the-art FTIR technology can transform your approach to gas analysis, making it simpler, more accurate, and adaptable to even the harshest industrial environments.Key takeaways will include:<ul><li>Modern FTIR gas analysis methods can dramatically simplify your operations.</li><li>Advanced analyzers that can easily integrate into your existing infrastructure.</li><li>Robust equipment designed to withstand challenging industrial conditions.</li><li>Elevate your gas analysis game and drive unparalleled efficiency in your production processes. Don’t miss out—click here to register today!</li></ul>

Quantum Analytics: Unleashing the Power of FTIR-Based Gas Analysis

Unleashing the Power of FTIR-Based Gas Analysis

State-of-the-art FTIR-based gas analysis technology can transform your approach to gas analysis

BET surface area of excipients and APIs plays a vital role in determining dissolution rates of tablets and capsules. Understanding the surface area helps decode issues related to dissolution rate failures and reduces time lost to trial and error. Learn how to comply with USP 846 (specific surface area, ultra-low surface area samples) using nitrogen instead of expensive krypton.<blockquote>Presenter: Robin IsyasDr. Robin Isyas is the Global Product Manager at Anton Paar and is based in Boynton Beach Florida USA. He has a diverse experience of 20 years in the industry. After his Ph.D. in UV Vis Spectroscopy, he worked as a research scientist in the Pharmaceutical industry. With a successful stint in research, he moved to the Analytical instrumentation industry where he held multiple leadership roles in Sales, Marketing, and Product Management. In his current role as Global Product Manager, he is responsible for developing new technologies in the field of Surface Area and Pores by working in collaboration with different industries like Pharmaceuticals, Cement, Food, Cosmetics, EV Battery, Carbon, Catalyst etc. &nbsp;</blockquote>

Anton Paar: BET surface area measurement of excipients and its impact on dissolution rates

BET surface area measurement of excipients and its impact on dissolution rates

Learn how to comply with USP 846 (specific surface area, ultra-low surface area samples) using nitrogen instead of expensive krypton.