<p><strong>Solid Phase Extraction (SPE) is one of the most highly selective sample preparation methods, meaning that the targeted analytes and their matrices must be considered when choosing the correct SPE sorbent and format. Drying down the sorbent before elution is an important step.</strong></p><ul><li>Wash solvents are used to flush out unwanted compounds (i.e., contaminants). If the wash solvent is not completely removed, then residual wash solvent could contaminate the final elution.</li><li>If you do not dry the SPE sufficiently, it could make the final solution less concentrated and result in a reduction in sensitivity.</li><li>Drying helps physically break down the interactions between the sorbent and analyte for a more concentrated extract.</li></ul><p>After the wash solvent has been passed through the cartridge, continue to apply negative pressure (vacuum) or positive pressure. Use this pressure to dry the cartridge for 2 to 5 minutes (or until dry). Turn off the pressure and wipe the tips of the manifold needles to remove any residual solvent.</p><h5><strong>Notes</strong></h5><ol><li><strong>Reproducibility:</strong> Drying removes traces of residual sample/matrix and wash solvent from the sorbent. This produces a more concentrated final extract with a consistent volume and composition and yields better reproducibility and higher recoveries.</li><li><strong>Immiscibility:</strong> Drying is especially critical when using elution solvents that are immiscible with water (e.g. hexane, ethyl acetate, and methylene chloride). Residual water in the sorbent bed may prevent dissolution of the analyte in the elution solvent, resulting in low recoveries and irreproducibility.</li><li><strong>Over-drying: </strong>Avoid over-drying the sorbent, since in some cases, analyte recovery may decrease with excessive vacuum or drying times above 5 minutes. Dry cartridges look distinctly different from moist ones. Make a note of the cartridge appearance before and after conditioning. Also, you could touch the cartridge while it is drying; wet cartridges feel colder than dry cartridges.&nbsp;</li></ol>

Why Is It Necessary to Dry the SPE Sorbent Before Elution?

<p><strong>🎤 Presenter:</strong> Sarah C. Foster (William &amp; Mary)</p><p>💾 <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/redirect?event=video_description&amp;redir_token=QUFFLUhqbFk5RFV6cGdVaThIVjRSQ0N3OVFkdzE5d2Y0QXxBQ3Jtc0trUHhzWGtLeTNKcFVhelU3X1E3U3A4Z1ZHUDBkME02MDl1ajk1QnpFc25ka3ZKUlhKOFVOdDZocnAwTEZZOTZEUE84cWJTUEVUVjgyY0FvT2xBcmpkenVYOVJTd3d0a1pQNVJkSENfZXFsVmF0dF9rMA&amp;q=https%3A%2F%2Fgcms.labrulez.com%2Flabrulez-bucket-strapi-h3hsga3%2FO_2_Foster_04b38f9b88.pdf&amp;v=e5w4zwhBzRY"><strong>PDF presentation</strong></a></p><h3><strong>Abstract</strong></h3><p><strong>Fermentation is a byproduct of microbial metabolism. When beverages become fermented, the microorganisms involved produce volatile organic compounds (VOCs). It is important to examine the VOC profile of fermented beverages to understand their consumer perception and health considerations. Traditionally, VOCs are detected by gas chromatography-mass spectrometry (GC-MS). However, more complex matrices, like fermented products, benefit from the enhanced separation of comprehensive two-dimensional gas chromatography (GC×GC). This study aimed to develop an understanding of the VOCs related to different fermented beverages through a nontargeted lens via comprehensive two-dimensional gas chromatography with dual detection using flame ionization detection and time-of-flight mass spectrometry (GC×GC-FID/TOFMS).&nbsp;</strong></p><p>Data analysis focused on developing a complete VOC profile of fermented products. Moreover, analysis aimed to identify differentiating VOCs to understand differences between products and distinguish the drink matrix from the microbial matrix. Results indicate that it is possible to attribute VOCs to one component of a complex sample, creating a microbial VOC profile and a base VOC profile. It was possible to discern products from one another, including contaminated products from non-contaminated products. Data visualization consisted of Principal Component Analysis (PCA) scores and loadings plots, bar chats, Hierarchical Cluster Analysis (HCA), and Partial Least Squares Discriminant Analysis (PLS-DA). Data analysis software was capable of processing and aligning samples with high levels of biological variation, making GC×GC a promising analytical tool for market research and regulation. Future studies will aim to correlate VOCs detected via GC×GC-FID/TOFMS to the microbial genetics of fermented products.</p><h3><strong>Video Transcription</strong></h3><h4><strong>1. Introduction</strong></h4><p>Sarah Foster introduces research focused on the application of comprehensive two-dimensional gas chromatography (GC×GC) for analyzing fermented beverages.</p><p>The laboratory primarily uses <strong>GC×GC</strong> for:</p><ul><li>Separation and identification of volatile organic compounds (VOCs)</li><li>Applications in forensic sciences and food sciences</li></ul><h5><strong>Forensic Applications</strong></h5><ul><li>Fingerprint residue</li><li>Gunshot residue</li><li>Pepper spray</li><li>Other trace evidence</li></ul><h5><strong>Food Science Applications</strong></h5><ul><li>Fermented beverages</li><li>Foods claiming health benefits</li></ul><p>An additional focus of the lab is transitioning GC×GC from proof-of-concept research toward real-world field applications, including improved data interpretation and presentation.</p><h4><strong>2. Challenges in Non-Targeted GC×GC Data</strong></h4><p>Working with complex, non-targeted datasets presents several challenges:</p><ul><li>Resolution of complex coelutions</li><li>Increased number of detectable features</li><li>Expansion of compound classes</li><li>Detection of low-level analytes previously masked by abundant compounds</li><li>Difficulty in longitudinal tracking due to increased data complexity</li></ul><p>While GC×GC reveals more chemical information, interpreting this data becomes more demanding.</p><h4><strong>3. Data Processing and Statistical Tools</strong></h4><h5><strong>Software Used</strong></h5><ul><li><strong>ChromaTOF</strong> – for single chromatogram peak detection and deconvolution</li><li><strong>ChromaTOF Sync 2D</strong> – alignment software for entire datasets</li><li><strong>R statistical software</strong> – for multivariate visualization<ul><li>vegan package</li><li>ComplexHeatmap package</li></ul></li></ul><h5><strong>Advantages of Sync 2D</strong></h5><ul><li>Performs peak detection and deconvolution across all chromatograms simultaneously</li><li>Generates a unified peak table for entire datasets</li><li>Facilitates trend analysis</li></ul><h5><strong>Dimensionality Reduction Techniques Used</strong></h5><ul><li>Principal Component Analysis (PCA)</li><li>Principal Coordinate Analysis (PCoA)</li><li>Hierarchical Cluster Analysis (HCA)</li></ul><p>Each data point includes:</p><ul><li>Primary retention time</li><li>Secondary retention time</li><li>Signal intensity</li></ul><h4><strong>4. Statistical Approaches Explained</strong></h4><h5><strong>PCA (Principal Component Analysis)</strong></h5><ul><li>Uses Euclidean distance</li><li>Assumes linear variance structure</li><li>Clustering based on shared analytes</li><li>Identifies key analytes driving variance</li><li>Loadings plots explain separation patterns</li></ul><h5><strong>PCoA (Principal Coordinate Analysis)</strong></h5><ul><li>Uses non-Euclidean dissimilarity (e.g., Bray–Curtis)</li><li>Emphasizes compositional differences</li><li>Better for non-linear variance structures</li></ul><h5><strong>HCA (Hierarchical Cluster Analysis)</strong></h5><ul><li>Uses Euclidean dissimilarity (in this study)</li><li>Clustering based on:<ul><li>Presence/absence</li><li>Relative abundance</li></ul></li><li>Output: dendrogram<ul><li>Short branches = more similar</li><li>Long branches = more dissimilar</li></ul></li></ul><h4><strong>5. Research Goals</strong></h4><ul><li>Apply GC×GC-TOFMS for volatile analysis and aroma profiling of mead</li><li>Investigate impact of:<ul><li>Yeast strain</li><li>Honey concentration</li></ul></li><li>Use a non-targeted analytical approach</li><li>Extract and compare chemical features across samples</li></ul><h4><strong>6. Mead Production Overview</strong></h4><p>Mead is produced by fermenting honey with filtered water. Fruits or spices may be added. It may also be barrel-aged.</p><h5><strong>Experimental Design (Silverhand Meadery Collaboration)</strong></h5><ul><li>1-gallon batches</li><li>5 yeast strains</li><li>3 honey concentrations:<ul><li>1.5 lb/gal (low alcohol, expected dry finish)</li><li>3 lb/gal (standard)</li><li>5 lb/gal (high alcohol, expected sweet finish)</li></ul></li></ul><h5><strong>Yeast Strains Tested</strong></h5><ul><li><strong>Kveik Voss</strong> – neutral with citrus notes</li><li><strong>Munich</strong> – banana, clove (esters &amp; phenols)</li><li><strong>EC1118</strong> – neutral (sparkling wine yeast)</li><li><strong>D47</strong> – tropical/white floral</li><li><strong>Abbaye</strong> – temperature-dependent:<ul><li>Low temp: banana, tropical, spicy</li><li>High temp: raisin, fig</li></ul></li></ul><p>Fermentation lasted 9 months. Stabilizers were added post-fermentation.</p><h4><strong>7. Sample Preparation</strong></h4><h5><strong>Mead Samples</strong></h5><ul><li>3 mL in 20 mL headspace vial</li><li>0.5 g salt</li><li>5 µL (500 ppm) 1-decanol internal standard</li></ul><h5><strong>Honey Samples</strong></h5><ul><li>1.5 g honey + 1.5 mL water</li><li>Salt + internal standard</li></ul><h5><strong>Water Controls</strong></h5><ul><li>3 mL water + salt + internal standard</li></ul><p>All samples were vortexed and analyzed by GC×GC-TOFMS.</p><h4><strong>8. Instrumentation</strong></h4><p>Instrument: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=24&amp;search=Pegasus+BTX+4D"><strong>LECO Pegasus BTX 4D GC×GC-TOFMS</strong></a></p><p>Features:</p><ul><li>Dual TOFMS and FID detection</li><li>Reverse fill/flush modulator</li><li>Flow splitter</li></ul><p>The modulator:</p><ul><li>Fills loop in forward direction</li><li>Flushes to secondary column</li><li>High secondary flow split between TOFMS and FID</li></ul><h4><strong>9. Initial Observations</strong></h4><p>Key compounds identified:</p><ul><li>Furfurol (heated honey marker)</li><li>2-ethylhexanol (water)</li><li>3-methylbutanol (fermentation product)</li><li>Benzaldehyde (fermentation product)</li></ul><p>Total detected: <strong>96 volatile organic compounds</strong></p><h4><strong>10. Multivariate Results</strong></h4><h5><strong>PCA Findings</strong></h5><ul><li>Four groupings largely dictated by honey concentration</li><li>1.5 lb/gal group clustered together</li><li>3 lb/gal group tightly clustered</li><li>5 lb/gal showed pattern similar to 1.5 lb/gal</li><li>Abbey yeast formed a distinct cluster</li></ul><h5><strong>PCoA Findings</strong></h5><ul><li>Similar overall patterns</li><li>Abbey yeast more distinctly separated</li><li>Likely due to Bray–Curtis dissimilarity emphasizing compositional differences</li></ul><h5><strong>HCA + Heatmap Findings</strong></h5><ul><li>Clustering aligned with PCA/PCoA trends</li><li>Abbey yeast again formed distinct grouping</li><li>Appeared to contain similar compounds but in lower relative abundances</li></ul><p>Two major overall clusters:</p><ul><li>1.5 lb/gal group</li><li>All other meads</li></ul><h4><strong>11. Compound Trends vs Honey Concentration</strong></h4><p>Observed correlations:</p><ul><li><strong>Ethyl lactate</strong>: increased with honey concentration</li><li><strong>Furfurol</strong>: increased with honey concentration</li><li><strong>3-methylbutanol</strong>:<ul><li>Decreased with honey concentration (except Abbey strain)</li></ul></li><li><strong>Ethyl octanoate</strong>:<ul><li>Highest at 3 lb/gal</li><li>Lowest at 1.5 lb/gal</li><li>Intermediate at 5 lb/gal</li></ul></li></ul><p>Abbey strain showed unique behavior, possibly explaining its distinct clustering.</p><h4><strong>12. Conclusions</strong></h4><ul><li>GC×GC-TOFMS is highly effective for aroma profiling of mead</li><li>Dimensionality reduction techniques successfully highlighted relationships between samples</li><li>Honey concentration strongly influences volatile profile</li><li>Yeast strain (especially Abbey) significantly impacts composition</li></ul><h4><strong>13. Future Work</strong></h4><ul><li>Investigate microbial environment effects on VOC production</li><li>Link microbial kinetics data to volatile profiles</li><li>Explore compound-class-specific trends</li></ul><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote>

Application of GC×GC for the investigation of fermented beverages (Sarah C. Foster, MDCW 2026)

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 16th February 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you technical note by <strong>Agilent Technologies, </strong>presentation by<strong> MDCW / C³AL </strong>and<strong> </strong>application notes by<strong> BaySpec </strong>and<strong> Shimadzu!</strong></p><h3><strong>1. Agilent Technologies: Why Do Loss of Resolution and Retention Time Shift Occur After Installing a New GC Column?</strong></h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_loss_resolution_retention_time_shifts_gc_column_5994_8773en_agilent_e5e79a5f5e.pdf"><strong>Full PDF for download</strong></a></li></ul><p>When a new column is installed on an instrument that has been running an application for a long time, and all the instrument parameters are set to the same values as before, the resolution between a pair of critical analytes can drop unacceptably, creating concern that the column is defective.&nbsp;</p><p>The chromatograms that accompany columns like these will show that the retention times of the poorly resolved peaks on the new column have shifted. This difference indicates a change in linear velocity of the carrier gas, since the run conditions were the same.&nbsp;</p><p>Why did the retention times of those compounds shift under seemingly identical run&nbsp;conditions? The answer is that the run conditions are not identical because the columns are not truly identical. In any manufacturing process, products are built to tolerances. In the case of a GC capillary column, these tolerances include diameter and length. Even small differences in diameter and length will affect the actual velocity and flow rate through a column at a given head pressure.</p><h3><strong>2. BaySpec: Illicit Drug Detection &amp; Identification Using the Continuity™ Field Portable Mass Spectrometer</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Bay_Spec_App_Note_C101_Illicit_Drug_Detection_1_5bd32f3fe9.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The trafficking and abuse of illicit drugs inflict tremendous harm upon individuals, families, and communities throughout the United States and the world. Based on the report of the United Nations Office on Drugs and Crime, nearly 296 million people worldwide used drugs in 2022, with an estimated 64 million suffering from drug use disorders. The opioid epidemic alone has claimed over 160,000 lives in the United States over the past two years, highlighting the urgent need for effective measures to combat this scourge.</p><p>Traditional methods of drug detection, such as laboratory-based analysis, are often time-consuming, costly, and require specialized personnel. These limitations make it challenging to address the rapid and widespread nature of drug trafficking and abuse. Moreover, the constant evolution of synthetic drugs and new psychoactive substances poses a significant challenge for law enforcement and public health officials, as these substances often evade detection using conventional methods.&nbsp;</p><p>In recent years, portable mass spectrometry has emerged as a promising solution for the rapid detection and identification of illicit drugs. Unlike traditional laboratory instruments, portable mass spectrometers offer the advantage of on-site analysis, enabling law enforcement officers and first responders to quickly identify substances in real-time. This technology can be deployed in various settings, including border checkpoints, public events, and field investigations, providing a versatile and efficient tool for combating drug-related crimes. As the opioid crisis and the rise of synthetic drugs continue to pose significant challenges, the integration of portable mass spectrometry into drug detection strategies represents a critical step towards a safer and healthier society.</p><h4><strong>Instrumentation&nbsp;</strong></h4><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2218"><strong>BaySpec Continuity™ Portable Mass Spectrometer</strong></a> was used equipped with a Swab-APCI source, specifically designed for TSA-approved swabs. The samples on swabs were converted into vapors via the Swab vaporizer unit, which then were drawn into the ionization chamber by the built-in sampling pump.</p><h4><strong>Conclusions&nbsp;</strong></h4><p>In this study, we demonstrated the use of the Continuity™ Field Portable Mass Spectrometer equipped with a SwabAPCI ionization source for the detection and identification of various drugs. The capabilities of the instrument were assessed through the creation of calibration curves and surface sampling experiments using ten drug standards and four selected analytes: fentanyl, cocaine, methamphetamine, and MDMA. By serial diluting these standards in methanol, we established calibration curves and determined the instrument’s Limits of Detection (LODs) in MS2 mode. These experiments highlighted the instrument’s ability to detect trace amounts of drugs with high sensitivity and specificity.&nbsp;</p><p>The performance of the Continuity™ field portable mass spectrometer in both controlled and real-world scenarios underscores its potential as a rapid, on-site analytical tool. The results obtained from triplicate measurements reinforce the reliability of this method, making it a valuable asset for law enforcement and public health agencies in their efforts to combat drug-related issues. This study confirms that the portable MS system can quickly and effectively identify illicit substances, offering a practical solution for field investigations and real-time decision-making. As the landscape of illicit drug use continues to evolve, such advancements in portable analytical technology will be crucial in providing timely and accurate information for intervention and prevention strategies.</p><h3><strong>3. MDCW / C³AL: COUNTING DOUBLE BONDS: GC×GC–FID FOR PLASTIC PYROLYSIS OILS</strong></h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_26_Petr_Vozka_04ef50f601.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The presentation focuses on the analytical challenge of accurately quantifying olefins (double bonds) in plastic pyrolysis oils and alternative fuels derived from plastic waste. As chemical recycling processes such as pyrolysis and hydrothermal processing gain importance, detailed compositional analysis becomes essential. Pyrolysis oils are highly complex mixtures containing paraffins, iso-paraffins, olefins, cycloalkanes, aromatics, and multi-ring structures. Because olefin content strongly affects fuel stability and upgrading requirements, reliable quantification is critical.</p><p>Traditional bulk methods such as bromine number, bromine index, iodine value, FTIR, Raman, and NMR provide only total unsaturation and often suffer from interferences or limited selectivity. To achieve detailed group-type and compound-level analysis, the authors apply comprehensive two-dimensional gas chromatography with flame ionization detection (GC×GC–FID). This technique delivers high resolution, reduces co-elution, and enables classification of linear, branched, cyclic, and aromatic olefins across wide boiling ranges.</p><p>To further improve quantitative accuracy, a selective adsorption approach using silver-modified silica (Ag–SiO₂) solid-phase extraction is introduced. Olefins are selectively retained, and comparison of GC×GC–FID chromatograms before and after adsorption allows precise determination of olefin content. This method is shown to be cost-effective and reliable for samples containing more than 5 wt% olefins.</p><p>Additionally, the presentation explores chemical derivatization of olefins using dimethyl disulfide (DMDS) and other disulfides to improve structural identification and quantification. While effective for lighter gasoline-range samples, challenges remain for heavier fuels such as jet and diesel fractions. Ongoing work focuses on testing heavier disulfides, optimizing reaction conditions, and validating results using ¹H NMR spectroscopy and future TOFMS analysis.</p><h3><strong>4. Shimadzu: Analysis of Polycyclic Aromatic Hydrocarbons (PAHs) in Tattoo Inks Using GC-MS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_09_ssk_023_en_ff47795f55.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>&nbsp;GCMS-QP2020 NX supports effective analysis of PAHs in Tattoo inks.</li><li>It provides an MFDS-based GC-MS method for PAHs in tattoo inks, enabling compliance with Korean regulations.</li></ul><p>Tattoo inks have been utilized for diverse purposes throughout history, serving as cultural identifiers and means of personal expression. In contemporary society, tattooing extends beyond aesthetics and self-expression to include medical applications such as camouflage of scars and post-operative rehabilitation. Because these inks are injected directly into the dermal layer, rigorous safety and hygienic control are essential to ensure human health protection.&nbsp;</p><p>Among the regulated constituents in tattoo inks, polycyclic aromatic hydrocarbons (PAHs) are of particular concern. PAHs comprise over a hundred structurally related compounds, commonly generated through incomplete combustion processes, vehicle exhaust, and tobacco smoke. Several PAHs have been classified as carcinogenic, and chronic exposure may lead to bioaccumulation and subsequent adverse health effects.&nbsp;</p><p>In January 2022, the European Union implemented stringent restrictions through updated REACH regulations, limiting the presence of approximately 4,000 hazardous substances in tattoo and permanent make-up inks, including PAHs. 1) These regulations prohibit the use of carcinogenic, mutagenic, and sensitizing substances previously detected in such products. Since the enforcement date, only compliant inks are permitted for distribution and use within the EU.&nbsp;</p><p>In South Korea, tattoo inks were regulated as consumer chemical products under the Ministry of Environment until June 2025. Due to increasing safety concerns, they have since been reclassified as sanitary products under the authority of the Ministry of Food and Drug Safety (MFDS), resulting in the implementation of more stringent safety requirements. 2)&nbsp;</p><p>This application news introduces the analytical methodology for quantification of PAHs in tattoo inks based on the MFDS regulatory standards (Notice 2025-36). Samples were prepared in accordance with the prescribed protocol, and PAH concentrations were determined using gas chromatography– mass spectrometry (GC-MS) in selected ion monitoring (SIM) mode.</p><h4><strong>Analytical Conditions&nbsp;</strong></h4><p>For the determination of PAHs in tattoo inks, a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-QP2020+NX"><strong>GCMS-QP2020 NX</strong></a> system was employed, as shown in Figure 1. The instrumental parameters and selected ion monitoring (SIM) conditions used for PAH analysis are summarized in Table 1.</p><h4><strong>Conclusions</strong></h4><p>Quantitative analysis of PAHs in tattoo inks was performed using the GCMS-QP2020 NX. Sample preparation followed the procedure outlined in the MFDS ‘Standards and Specifications for Sanitary Products.’ All eight PAH analytes showed excellent linearity, with correlation coefficients (R²) exceeding 0.999. Recovery tests showed values between 81.6% and 115.1%, with relative standard deviations (%RSD) ranging from 0.11% to 3.13%, demonstrating good accuracy and precision. These results confirm that the GCMS-QP2020 NX is a suitable instrument for PAH analysis in tattoo inks.</p>

News from LabRulezGCMS Library - Week 08, 2026

Article

Application

Academy

Video

Presentation

The Multidimensional Chromatography (MDC) Workshop draws experts in this exciting field to share and discuss their research.

The Multidimensional Chromatography Workshop

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in industrial, government and academic laboratories.

Phenomenex

Separation Science

Agilent Technologies

PerkinElmer

Restek Corporation

SelectScience

Waters Corporation

<p><strong>The application of gas chromatography and vacuum ultraviolet spectroscopy (GC-VUV)  has rapidly evolved from a new disruptive technology to an invaluable scientific technique in the modern analytical laboratory.  The adoption of GC-VUV is due in large part to its universal detection capabilities, unique selectivity, sensitivity, and deconvolution capabilities. The technical capabilities of the detector combined with a portfolio of flexibile and versatile standard methods makes it an ideal technique for R&amp;D and routine analysis.</strong></p>
<blockquote>
<p><strong>Presenter:  Alex Maitan (Field Application Specialist, PerkinElmer)</strong></p>
</blockquote>
<blockquote>
<p><strong>Presenter: Dan Wispinski (Standard Methods Development Manager, VUV Analytics)</strong></p>
</blockquote>


PerkinElmer University Online Learning: Gas Chromatography Spring 2021 Semester

The Evolution of GC-VUV

<p><strong>Agilent is delighted to welcome you to the #SuperSmartGC Virtual Meeting.</strong></p>
<p>This is a virtual event to share the latest in Agilent&#39;s smart, connected Gas Chromatography instruments.</p>
<p>We will introduce the new <strong>8697 headspace sampler</strong> with, intelligent self-awareness; Agilent&#39;s first headspace sampler with integrated GC communication. Prevent downtime and troubleshoot problems with the knowledge you can migrate your legacy methods with confidence.</p>
<p>The meeting is a mix of live presentations and on-demand content you can join and view, wherever you are and whenever you can.</p>
<p><strong>Live broadcast presentation with Q&amp;A from 1:30 PM CET</strong></p>
<h5><strong>1. Introducing the 8697 Headspace Sampler</strong></h5>
<blockquote>
<p><strong>Presenter: Cassie Eisele</strong> (Product Manager, Agilent Technologies Inc, USA)</p>
</blockquote>
<h5><strong>2. Climbing the peaks of GC Intelligence, Life with your Smart GC from Agilent.</strong></h5>
<blockquote>
<p><strong>George Reiner</strong> (GC Software Product Manager, Agilent Technologies Inc, USA)<br/><strong>James McCurry</strong> (Senior Applications Chemist, Agilent Technologies Inc, USA)</p>
</blockquote>
<h5><strong>3. Residual Solvents Analysis with the Agilent 8697 Headspace Sampler</strong></h5>
<blockquote>
<p><strong>Ian Eisele</strong> (Applications Specialist, Agilent Technologies Inc, USA)</p>
</blockquote>
<p>As always this is your meeting - feel free to chat with other users and our team of experts, give us your feedback and requests for development. </p>
<p>Register today and stay up-to-date with the latest technological developments.</p>


Agilent Technologies: Agilent SuperSmartGC Virtual Meeting

Agilent SuperSmartGC Virtual Meeting

<p>It is estimated that over 35% of irreproducibility has been attributed to manual errors in the performance of experiments and data reporting, which results in unnecessary costs totaling around $28 billion in order to repeat experimental work (The Economics of Reproducibility in Preclinical Research. PLOS Biology 13(6): e1002165).</p>
<p>Automation looks to increase efficiency, speed, and reproducibility and lower costs by replacing manual methods. The majority of results generated with manual manipulation are still captured via paper and susceptible to error. If you have ever tried to repeat a method from a colleague’s laboratory notebook, you know how challenging this can be and this is compounded if colleagues cannot be physically there to go through it with you.</p>
<h5><strong>This virtual event brings you three webinars from experts in the field of automation who will discuss how you can work smarter by:</strong></h5>
<ul>
<li>Using automated pipetting to increase accuracy, consistency and efficiency</li>
<li>Leveraging automated sample preparation, liquid handling and cloud-native software to accelerate your development and derisk transferring methods between operators on a global scale</li>
<li>Understanding compliance and sample traceability as part of the automated workflow</li>
</ul>
<h5>Session 1 - 15:00 BST / 16:00 CEST / 10:00 EDT / 07:00 PDT</h5>
<p><strong>Improving efficiency and reproducibility by automating common LC-MS sample preparation protocols</strong></p>
<ul>
<li>Speakers: Melvin Blaze and Kathryn Brennan, Waters Corporation</li>
</ul>
<h5>Session 2 - 16:00 BST / 17:00 CEST / 11:00 EDT / 08:00 PDT</h5>
<p><strong>Automating endotoxin testing using the Andrew+ Pipetting Robot</strong></p>
<ul>
<li>Speaker: Dr. Robert D’Ordine, Senior Scientist, Associates of Cape Cod</li>
</ul>
<h5>Session 3 - 17:00 BST / 18:00 CEST / 12:00 EDT / 09:00 PDT</h5>
<p><strong>Follow that sample: The importance of compliance and traceability in the automated laboratory</strong></p>
<ul>
<li>Speakers: Heather Longden and Guillaume Mignard, Waters Corporation</li>
</ul>
<h3><strong>Who Should Attend?</strong></h3>
<p>The content of this event is ideal for those interested in learning more about how to increase their laboratory efficiency with simple-to-use and easy-to-implement affordable automation solutions. In addition, any pharmaceutical or CRO laboratory that transfers methods often and is looking to de-risk and improve success.</p>
<blockquote>
<p><strong>Presenter: Dr. Melvin Blaze (Principal Scientist, Waters Corporation)</strong></p>
</blockquote>
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<p>Dr. Melvin Blaze (Ph.D. in chemistry, University of Illinois at Chicago) is currently working for Waters Corporation as a principal scientist. He is involved in the research and development of solid-phase extraction (SPE) and automated sample preparation. He has over 10 years of combined experience in food, beverage and pharmaceutical research, specializing in small molecule analysis ranging from new chemical entities and antibiotics to endogenous metabolites in biological, food, beverage and pharmaceutical matrices using state-of-the-art separation and mass spectrometry techniques.</p>
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<p><strong>Presenter: Kathryn Brennan (Applications Scientist, Waters Corporation)</strong></p>
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<p>Kathryn Brennan (B.S. in environmental science, UMass Amherst) joined Waters Corporation as an applications scientist in 2018. Prior to joining Waters, she spent two years working for an environmental CRO conducting pesticide analysis studies. Kathryn’s focus since joining Waters Corporation has been leveraging the use of Waters instrumentation, columns, and consumables for method development, application support, and product development. With a strong emphasis on sample preparation, her work includes automating sample preparation workflows using Waters automated platforms, as well as Hamilton robotics, for liquid handling and solid-phase extraction processes with the intention of providing more efficient and robust LC-MS applications.</p>
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<p><strong>Presenter: Dr. Robert D’Ordine (Senior Research Scientist, Associates of Cape Cod, Inc. )</strong></p>
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<p>Robert is a senior research scientist in research and development at Associates of Cape Cod, Inc.  Robert is an author on 20 peer-reviewed publications and patents and has over 20 years of experience in biotechnology, working in areas ranging from genomics and protein characterization to biochemistry and diagnostics. Robert has 10 years of experience with LAL-based assays and specializes in glucan detection methods. In his current role, Robert interfaces with quality control, product development, clinical development and technical services engaging in automated assay adaptation, methods development, design and analysis of experiments, and technical problem solving.</p>
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<p><strong>Presenter: Heather Longden (Senior Marketing Manager, Pharmaceutical Intelligence, Waters Corporation)</strong></p>
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<p>After a number of years in training, supporting and selling Waters Software, Heather&#39;s current role is as a specialist in compliance to e-record regulations, acting as a resource to the global informatics community at Waters and the users of all Waters informatics products. </p>
</blockquote>
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<p>Heather’s work involves helping design the compliance into Waters informatics products and services, attending and presenting at specialist conferences, keeping up to date on the latest interpretations and amendments to the regulations and disseminating this information to the Waters field and corporate organizations, as well as Waters customers.Heather is active in the ISPE GAMP Community of Practice and the ISPE New England Chapter where she is called on as an expert in data integrity, specifically around the chromatographic analysis process</p>
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<p><strong>Presenter: Guillaume Mignard (OneLab Product Designer and Owner, Andrew Alliance, A Waters Company)</strong></p>
</blockquote>
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<p>Guillaume started his career as user experience and interface designer for business software at the time it was a trend only for web marketing website. After joining Andrew Alliance Software team in 2017, he became product designer and product owner of OneLab, a cloud-native software platform for making lab automation accessible to every scientist. He is responsible of the strategic direction of OneLab, the design and implementation of every features as well as the diffusion of what it is released to stakeholders and customers.</p>
</blockquote>


SelectScience: Leveraging automation technologies to work smarter

Virtual Event: Leveraging automation technologies to work smarter

<p><strong>Separation Science, in collaboration with Thermo Fisher Scientific, offers the first instalment of a three-part Instrument Selection Discussion Series where Laboratory Professionals gain knowledge on the choices of instrument available and which is most recommended for specific applications.</strong></p>
<p>Ensuring the safety of the world’s food supply is critical, but identifying and quantifying contaminants such as pesticides can be a significant challenge, particularly in widely differing environments under a variety of regulatory frameworks.</p>
<p>This webinar discussion forum, part 1 of the &#39;Instrument Selection Discussion Series&#39; takes a look at the pros and cons of LC-QqQ and GC-QqQ for the analysis of pesticides in food and agricultural matrices. Industry and technology experts will provide their insights on the various instrumental setups and workflows for analysing real-work samples and aim to address questions such as:</p>
<ul>
<li>What are the main challenges in the QqQ analysis of a comprehensive list of pesticides?</li>
<li>What are the most challenging sample matrices for pesticides analysis with QqQ instruments?</li>
<li>How can GC-MS/MS, LC-MS/MS or High Resolution Accurate Mass (HRAM) technology address counterfeiting issues?</li>
<li>Will laboratories use QqQ and HRAM as a complementary approach?</li>
<li>What will be the key improvements to these instrumental workflows in the near future?</li>
</ul>
<h5><strong>Our expert panelists for this discussion forum are:</strong></h5>
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<h5><strong>Bert Popping (FOCOS)</strong></h5>
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<p>Bert advises technology providers, food manufacturers, start-up companies, not-for-profit organizations, investors and laboratories on strategic food safety solutions and emerging technologies. Bert previously worked as Chief Scientific Officer and Director Scientific Development and Regulatory Affairs for global contract laboratories, and has 25 years of experience in the food testing industry.</p>
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<h5><strong>Katie Banaszewski (NOW Foods)</strong></h5>
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<p>Katie is the Analytical Lab Manager NOW Foods where she uses her 15 years of industry experience to lead, motivate and inspire a team of Analytical Chemists and Method Development Scientists. During her time at NOW, Katie has lead the development and implementation of a routine pesticide residue monitoring program and plays an integral role in growing the company’s analytical capabilities.</p>
</blockquote>
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<h5><strong>Łukasz Rajski (EURL-FV, University of Almería)</strong></h5>
</blockquote>
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<p>Łukasz is an expert in the development and validation of analytical methods for pesticide residues in food, working with advanced mass spectrometry techniques (both high-resolution and triple quadrupole) coupled to ultra-high performance liquid chromatography and high-performance ion chromatography.</p>
</blockquote>


Pixabay/Martin Ludlam: The Challenges of Pesticide Analysis - LC or GC Triple Quadrupole?

The Challenges of Pesticide Analysis - LC or GC Triple Quadrupole?

<p><strong>The new 8697 Headspace Sampler is the first Agilent headspace sampler to have integrated communication with the Agilent 8890, 8860, and Intuvo 9000 GCs. With its 48-vial capacity over two removable racks, it is considered ideal for those customers wanting to run a full day or night’s worth of samples. Integrated intelligence with the Agilent GCs means a true system approach to GC analysis, promising a smoother GC workflow. This allows you to get the results you need when, and where, you need them.</strong></p>
<p>The analysis of residual solvents in the pharmaceutical industry is one example of when this is required. These volatile organic compounds are typically essential to the production of pharmaceuticals but are unwanted in the final products. USP &lt;467&gt; defines the acceptable limits of these residual solvents, classifies them into three categories, and provides procedures for their analysis.</p>
<p>In this expert webinar, Cassie Eisele and Abbey Fausett, from Agilent Technologies, will present the new hardware and discuss the instrument intelligence features released with this instrument. They will also explore two application notes using the new 8697 headspace sampler for USP &lt;467&gt; residual solvents and blood alcohol analysis.</p>
<h3><strong>Learning outcomes:</strong></h3>
<p>Learn about the key features of the new Agilent 8697 headspace sampler and discover two key headspace methods:</p>
<ul>
<li>Residual solvent analysis</li>
<li>Blood alcohol analysis</li>
</ul>
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<p><strong>Presenter: Cassie Eisele (GC Sample Introduction Product Manager, Agilent)</strong></p>
</blockquote>
<blockquote>
<p>Cassie Eisele started with Agilent in 2009, after finishing her degree in biomedical engineering at Cornell University. For the first five years of her career, Cassie was doing technical support, walking customers through fixing their hardware and software so they could get back to their analysis.Since then, Cassie has been the GC Sample Introduction Product Manager. She has helped introduce new products and managed the product lineglobally to ensure the instruments are meeting customers’ needs.</p>
</blockquote>
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<p><strong>Presenter: Abbey Fausett (GC Applications Chemist, Agilent)</strong></p>
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<p>Abbey Fausett is an application chemist within Agilent’s Gas Phase Separation Division, located in Wilmington, Delaware. Prior to coming on board with Agilent, she worked as a methods chemist for the US Army in several locations, developing and validating analytical methods for material permeability, air sampling, and dispersion pattern experiments using military threat compounds and simulants. </p>
</blockquote>
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<p><strong>Moderator: Finn Price (Editorial Team, SelectScience)</strong></p>
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SelectScience: Simplify life in the lab with the new 8697 Headspace Sampler

Simplify life in the lab with the new 8697 Headspace Sampler

<p><strong>The Agilent GC Q-TOF delivers full-spectrum, high-resolution, accurate-mass data with a wide dynamic range for identifying and quantifying GC-amenable compounds. Whether it’s used in complex metabolomics studies, the routine analysis of dioxins, pesticide screening or compound identification in challenging matrices, quadrupole time-of-flight GC/MS provides the ultimate in performance.</strong></p>
<p>The 8890 GC continues Agilent&#39;s legacy as the provider of proven gas chromatography systems that deliver reliability and high performance. The most configurable gas chromatography system addresses whatever your specific analysis demands.</p>
<p>Together the 8890 GC and 7250 Q-TOF are designed for real-world analysis and built for laboratory robustness.</p>


Agilent Technologies: The versatile 7250 GCQTOF: From the knowns to the unknowns, MSMS and Accurate Mass

The versatile 7250 GCQTOF: From the knowns to the unknowns, MSMS and Accurate Mass

<p><strong>More and more companies are choosing to look toward financing options as opposed to capital expenditure to fund their laboratory purchases.  We discuss the benefits of this approach.​</strong></p>
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<p><strong>Presenter: Richard Styles (Director of Leasing EMEAI, Waters)</strong></p>
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<p>Richard has been with Waters for 5 years developing innovative, tailor made finance solutions for our customers. He has over 30 years of domestic and international experience through management roles at bank based and manufacturer captive leasing companies.​</p>
</blockquote>


StartupStockPhotos: Waters Corporation - Meet the Experts Webinars

Meet the Experts - Part 1 - Alternative Procurement Strategies

<p><strong>Solid phase microextraction (SPME) is a non-exhaustive technique that has been a game changer in the sample preparation area since its introduction in the early 90s.</strong></p>
<p>In this webinar, we will discuss the basics and principles of SPME. We will go over different experimental parameters that are critical in SPME method development and discuss the SPME Arrow to show how it can help you achieve great results with outstanding robustness and reliability.</p>
<p> After the webinar we will have a live Q&amp;A session.</p>


Restek: Solid phase microextraction (SPME): principle and introduction to the SPME-arrow configuration

Solid phase microextraction (SPME): principle and introduction to the SPME-arrow configuration

<h5><strong>In this webinar you will have an opportunity to discuss and learn:</strong></h5>
<ul>
<li><p>Critical components of GC</p>
</li>
<li><p>Different types of injection mode &amp; detectors</p>
</li>
<li><p>Importance of different column parameters for development &amp; column selection</p>
</li>
<li><p>What is Gas Chromatography and a typical Chromatogram?</p>
</li>
<li><p>Types of sample introduction techniques</p>
</li>
<li><p>Comparison on types of detectors and its selectivity</p>
</li>
<li><p>Digital and touch less customer support options</p>
</li>
</ul>
<blockquote>
<p><strong>Presenter: Sunil B Lakhmapure (Technical Support Specialist Consumables, Agilent Technologies Debesh)</strong></p>
</blockquote>
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<p><strong>Presenter: Shivangi Kanwasia (Account Manager, Services and Support Division, Agilent Techologies India)</strong></p>
</blockquote>
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<p><strong>Presenter: Preethi Warrier (Application Engineer , Solution Support, Agilent Technologies)</strong></p>
</blockquote>


Agilent Technologies: Enhance Your Lab Productivity Series

Enhance Your Lab Productivity Series – GC Basic

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<p><strong>Presenter: Richard Mutkoski (Laboratory Informatics Application Engineer, Agilent Technologies, Inc.)</strong></p>
</blockquote>
<blockquote>
<p><strong>Presenter: Kelly Beard (GC and GCMS Application Scientist, Agilent Technologies, Inc.)</strong></p>
</blockquote>


Agilent Technologies: Keep your GCMS Lab Open Using Agilent OpenLAB CDS Software