🎤 Presenter: Christopher Freye (Los Alamos National Laboratory)💾 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_1_Freye_10783a9cf3.pdf">PDF presentation</a><h3>Abstract</h3>Two-dimensional gas chromatography (<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?instrumentationItems=2">GC×GC</a>) when coupled with mass spectrometry (MS) especially high-resolution mass spectrometry (HRMS) provides the ideal technique to discover minute chemical changes. However, GC×GC analyses result in extremely large datasets (GBs of information) wherein the statistically significant chemical changes are buried within the background chemical matrix. To combat these issues, many chemometric techniques have been developed or applied. Recently we introduced a new chemometric technique for GC-MS termed alteration analysis (ALA) and two-dimensional correlation (2DCOR) which can be used to discover statistically significant chemical changes across a series of chromatograms and understand the relationship between the statistically relevant changes. ALA generates three sets of information, the basic alteration map (BAM) which is the magnitude of the change, the synchronous alteration map (SAM) which describes the linear change, and the asynchronous alteration map (AAM) which describes the non-linear change. 2DCOR can then be used to understand the relationship between the chemical changes but 2DCOR can also resolve the sequence of the changes. A workflow for GC×GC-MS will be demonstrated. Special attention will be given to what differentiates the GC×GC work flow from GC for both the ALA and 2DCOR.<h3>Video Transcription</h3>The presentation focuses on how advanced mathematical and chemometric methods can be used to extract meaningful information from highly complex chromatographic data, especially in multidimensional chromatography coupled with mass spectrometry (GC×GC-MS, LC-MS).<h4>Why traditional data analysis falls short</h4>Modern multidimensional chromatography generates extremely large datasets, often containing billions of data points. Visual inspection, peak tables, or classical identification-based workflows are impractical—especially when:<ul><li>Samples are highly complex (e.g. petroleum, metabolomics, high explosives)</li><li>Most compounds are unknown unknowns</li><li>The key question is not what the compounds are, but whether samples differ and how</li></ul>Program managers and decision-makers are primarily interested in detecting statistically significant changes, not exhaustive compound identification.<h4>Introduction of Alteration Analysis (ALA)</h4>To address subtle, trend-based changes across series of chromatograms, the speaker introduces Alteration Analysis (ALA), a chemometric approach adapted from spectroscopy and applied to chromatography.ALA quantitatively evaluates how individual data points change across multiple samples, allowing detection of:<ul><li>Extremely subtle trends</li><li>Overlapping peaks</li><li>Changes hidden in noise or baseline interference</li></ul>Key ALA outputs include:<ul><li>BAM (Basic Alteration Map): magnitude of change</li><li>SAM (Systematic Alteration Map): linear changes</li><li>AM (Alteration Map): nonlinear changes</li></ul>Even changes as small as 1% per sample can be detected reliably, including peaks that are heavily overlapped.<h4>Beyond detection: understanding relationships with 2D Correlation</h4>Once statistically significant changes are identified, two-dimensional correlation analysis (2D-COR) is used to understand relationships between changing compounds, including:<ul><li>Whether compounds are correlated or anti-correlated</li><li>The sequence of changes over time (which changes happen first)</li></ul>This is especially critical for degradation and aging studies, where intermediate species may appear and disappear before the final state—information that traditional methods like Fisher ratio or PCA often miss.<h4>Solving GC×GC challenges with tiling</h4>GC×GC data introduces additional challenges due to:<ul><li>Peak misalignment</li><li>Exponential data growth during correlation calculations</li></ul>The presenter explains how tile-based approaches reduce data dimensionality, overcome alignment issues, and make ALA and 2D correlation computationally feasible—even for massive GC×GC-MS datasets.<h4>Real-world application: explosive aging studies</h4>The methodology was applied to aging and decomposition of high explosives, where:<ul><li>Over 250 chemical changes were identified</li><li>Many intermediate species would have been missed using traditional comparisons</li><li>ALA combined with 2D correlation enabled reconstruction of degradation pathways</li><li>The most significant change was not necessarily the first change, a critical insight for risk assessment and stability studies</li></ul><h4>Key takeaway</h4>By combining Alteration Analysis and 2D correlation, the approach:<ul><li>Detects statistically guaranteed chemical changes</li><li>Handles subtle, overlapped, and noisy signals</li><li>Determines magnitude, type, interrelationships, and order of changes</li><li>Shifts chromatographic data analysis from identification-driven to decision-driven</li></ul>This math-driven workflow enables faster, more reliable interpretation of complex chromatographic datasets and provides actionable insights for applications such as explosive aging, pharmaceutical degradation, and complex mixture analysis.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote>

Discovery analysis for GCxGC trends using alteration and 2D correlation (Chris Freye, MDCW 2026)

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 9th February 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you technical note by Agilent Technologies, presentation by MDCW / University of Copenhagen and application notes by Shimadzu and Thermo Fisher Scientific!<h3>1. Agilent Technologies: What Causes Spots on <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?instrumentationItems=19&amp;manufacturerItems=1&amp;search=PLOT">PLOT Columns</a>? Will It Affect the Performance of the Column?</h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_what_causes_spots_plot_columns_affecting_performance_5994_8775en_agilent_3b7180512a.pdf">Full PDF for download</a></li></ul>Spots on porous layer open tubular (PLOT) columns are caused by small voids in the stationary phase coating inside the tube. These spots are areas where there is an uneven coating or lack of phase. It is normal to find some voids in the phase coating of PLOT columns. The stationary phase in PLOT columns is an opaque, solid, and porous material. In many Agilent PLOT columns such as the GS-Alumina phases, molecular sieves, porous polymers (Q and U), and the GS-OxyPLOT, the stationary phase is visible as a white powder. For many PLOT columns, the stationary phase fill solution is a viscous suspension of particles that are less than 10 microns in diameter. The phase is coated using a dynamic process in which a plug of fill solution is pushed through the tubing, and the plug’s speed and viscosity determines the thickness of the stationary phase layer. Once the PLOT’s stationary phase is deposited, it is held in place by electrostatic charge, chemical interactions between particles, and/or binding agents. In wall‑coated open tubular (WCOT) columns, stationary phases such as polysiloxanes or polyethylene glycols are immobilized by chemical bonding to the glass surface and cross-linking between polymer strands. Because this type of bonding and cross‑linking is not possible with PLOT phases, the result is a stationary phase layer that is both fundamentally different and inherently less stable in PLOT columns than in WCOT&nbsp;columns.<h3>2. MDCW / University of Copenhagen: One-shot tensor decomposition of full-scale GC×GC-VUV datasets for resolving petrochemical groups</h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_17_Schneide_67c8ff7866.pdf">Full PDF for download</a></li></ul>The presentation introduces a novel all-samples-at-once, shift-invariant tri-linear tensor decomposition approach for the analysis of full-scale <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?search=GC%C3%97GC-VUV">GC×GC-VUV</a> datasets, aimed at resolving and quantifying petrochemical groups. Traditional template-based or pixel-based methods struggle with retention-time shifts and co-eluting compounds, often requiring manual intervention and prior chemical knowledge. The proposed approach leverages the intrinsic low-rank structure of GC×GC-VUV data to enable robust, automated group-level analysis across multiple samples simultaneously.At the core of the method is a shift-invariant tri-linear model, conceptually related to PARAFAC and multivariate curve resolution, but extended using frequency-domain (FFT-based) modeling to explicitly account for chromatographic peak shifts. By decomposing the entire dataset in one step, the model provides accurate estimates of peak landscapes, VUV spectra, and relative peak areas, while remaining agnostic to retention-time variability. Importantly, the approach requires only a small number of tunable parameters, making it practical for routine use.The method was demonstrated on a case study involving 14 petrochemical gas-oil samples, including straight-run, hydrotreated, hydroconverted, coker, and light cycle oils. Extracted VUV spectra showed excellent agreement with reference spectra from a VUV spectral database, enabling confident assignment of components to chemical groups such as saturates, olefins, and mono- to poly-aromatics. Quantitative results exhibited high repeatability (RSD typically 3–9%) and strong correlation with established template-based reference methods.Overall, the work demonstrates that one-shot, shift-invariant tensor decomposition provides a powerful and scalable alternative to conventional GC×GC data-analysis strategies. By combining chemical interpretability, robustness to chromatographic shifts, and strong quantitative performance, the approach opens new opportunities for automated, high-confidence group-level analysis of complex petrochemical samples and beyond.<h3>3. Shimadzu: Py-Screener Ver. 3: Simultaneously Test for Substances Regulated Under RoHS, TSCA, and POPs</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00949_en_4754e50164.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>In just one analysis, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=Py-Screener">Py-Screener</a> Ver. 3 can determine levels of phthalate esters, brominated flame retardants (PBBs, PBDEs), PIP (3:1), UV-328, dechlorane plus (DP), short-chain chlorinated paraffins (SCCPs), and medium-chain chlorinated paraffins (MCCPs).&nbsp;</li><li>It can also test for SCCPs and MCCPs by electron ionization (EI) instead of negative chemical ionization (NCI).&nbsp;</li><li>PIP (3:1), UV-328, DP, and SCCPs and MCCPs can be screened without the need for corresponding reference materials.</li></ul>Countries and regulatory bodies worldwide are introducing increasingly stringent regulations on the chemical substances used in electronic devices and industrial products. The RoHS Directive and REACH regulations in the EU, the Toxic Substances Control Act (TSCA) in the USA, and the Stockholm Convention on Persistent Organic Pollutants (POPs) are also targeting an increasingly broad range of substances. Therefore, manufacturers are required to accurately identify regulated substances in their products and comply with each regulation. While Py-Screener Ver. 2 can screen for seven phthalate esters and brominated flame retardants, including substances regulated under the RoHS Directive, version 3 can also screen for PIP (3:1), which is regulated under the TSCA, as well as UV328, DP, and SCCPs and MCCPs , which are regulated under the Stockholm Convention on POPs. A list of supported substances isshown in Table 1. This article introduces the simultaneous analysis of multiple regulated substances and a case study of testing specific regulated substances in samples, using Py-Screener Ver. 3.<h4>Analysis Process</h4>Py-Screener Ver. 3 can determine levels of phthalate esters and brominated flame retardants contained in products in accordance with the international analytical standards IEC62321-8 and IEC62321-3-3. It can also test for specific regulated substances (Table 1) under the same conditions and in the same analysis. In this test, background intensity and instrument sensitivity (S/N) were verified before analyzing samples. These parameters are prescribed by IEC62321-8 to ensure the accuracy of the methods used. Background intensity and instrument sensitivity were determined using a reference material (PN: 225-31003- 91) *1 that consisted of a plastic sheet that was spiked with seven phthalate esters. The results met the criteria for both parameters.The testing workflow is shown in Fig. 1. Before testing samples, calibration curves were prepared by analyzing the 1000 mg/kg phthalate ester reference material and polypropylene spiked with brominated flame retardants (ERM-EC591). A hole puncher was used to punch out two discs at a time of the phthalate ester reference material, and a cutter was used to obtain pieces of the other materials. Each material was weighed in a sample cup for analysis. During the analysis of samples, phthalate esters and some of the regulated brominated flame retardants were quantitated using a one-point calibration curve. The remaining brominated flame retardants and specific regulated substances were quantitated using the correction factor database*2 that is included with Py-Screener Ver. 3.<h4>Conclusion</h4>Py-Screener Ver. 3 successfully determined in samples the concentrations of the regulated substances PIP (3:1), UV-328, DP, and SCCPs and MCCPs. Normally, SCCP and MCCP levels are tested using NCI, but Py-Screener Ver. 3 uses EI. This enables it to test for not only SCCPs and MCCPs but also phthalate esters, brominated flame retardants, and other regulated substances in just one analysis. In addition, by using the relative correction factors linked to DEHP in the phthalate ester reference material, the levels of these regulated substances were determined without the need for the corresponding reference materials. Py-Screener Ver. 3 can also create a screening program that addresses substance restrictions under the RoHS Directive, the US TSCA, and the POPs Convention.<h3>4. Thermo Fisher Scientific: Improving low carbon steel production in specialty steel processes</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/prima_pro_process_mass_spectrometer_an1626_7fc840235f.pdf">Full PDF for download</a></li></ul>World crude steel production reached 1,691 million tonnes in 2017, up by 5.3% compared to 2016.1 While much of this capacity is still produced in primary steel processes such as basic oxygen furnaces and electric arc furnaces, the need for refined steel with greater durability and resistance to heat and corrosion has led to the increased use of vacuum degassing processes, such as VOD and RH, in secondary steel production. These processes are able to achieve ultra-low levels of residual carbon, while at the same time retaining desired levels of other alloy materials. If these processes are to achieve the required level of steel product quality, they need fast, continuous gas analysis of the furnace exhaust gas. Without accurate information on the composition of the gas leaving the furnace, any variations in the decarburization process are only detected after the event, resulting in the production of out-of-specification steel.<h4>Advantages of mass spectrometry&nbsp;</h4>Traditional Non-Dispersive Infra-Red (NDIR) analyzers are used in many conventional steelmaking processes to measure CO and CO2 , but they can only sample at atmospheric pressure. In vacuum steelmaking the process pressure changes dramatically, typically from atmospheric pressure down to less than 1 mbar, over the 20-30 minutes of the melt. So NDIR analyzers have to sample some distance downstream from the process. Analytical data is updated several minutes after the gas leaves the melt and the control system is forced to operate on historic rather than real-time data.&nbsp;Paramagnetic analyzers can be used to measure O2 , while thermal conductivity analyzers can be used to measure H2 . These analyzers also suffer from slow response, while the need to operate three different types of analyzers adds to the plant maintenance burden. Moreover, the three analyzers cannot analyze inert gases, so N2 is calculated by difference, a result that suffers from the sum of the errors of the three analytical techniques.&nbsp;Mass spectrometry operates at high vacuum so it is ideal for monitoring vacuum processes. It is also able to monitor all seven components in Table 1 in seconds rather than minutes, ensuring the plant control model is frequently updated with accurate compositional data.<h4>Precision of analysis&nbsp;</h4>At the heart of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=Prima+PRO+Mass+Spectrometer">Thermo Scientific™ Prima PRO Mass Spectrometer</a> (MS) is a magnetic sector analyzer which offers unrivalled precision and accuracy compared with other mass spectrometers. Thermo Fisher Scientific manufactures both quadrupole and magnetic sector mass spectrometers; over thirty years of industrial experience have shown the magnetic sector based analyzer offers the best performance for industrial on-line gas analysis.&nbsp;Key advantages of magnetic sector analyzers include improved precision, accuracy, long intervals between calibrations, and resistance to contamination. Typically, analytical precision is between 2 and 10 times better than a quadrupole analyzer, depending on the gases analyzed and complexity of the mixture.&nbsp;A unique feature of the Prima PRO magnet is that it is laminated. Its analysis times are similar to a quadrupole analyzer, offering the unique combination of rapid analysis and high stability. This allows the rapid and extremely stable analysis of an unlimited number of user-defined gases. The scanning magnetic sector is controlled with 24-bit precision using a magnetic flux measuring device for extremely stable mass alignment.&nbsp;The ion source is an enclosed type for high sensitivity, minimum background interference, and maximum contamination resistance. This is a high-energy (1000 eV) analyzer that offers extremely rugged performance in the presence of gases and vapors that have the potential for contaminating the analyzer. Typical performance specifications for the Prima PRO MS are shown in Table 1. Analytical performance is demonstrated by analyzing the calibration bottle over 1 hour following calibration, with an analysis time of just 6 seconds. Standard deviations measured on the calibration cylinder will be equal to or better than the stated values.

News from LabRulezGCMS Library - Week 07, 2026

Although modern agriculture needs to be based on accurate real-time data on soil, plant, and environmental conditions, affordable, sufficiently sensitive, and robust monitoring devices for this purpose are currently missing. According to scientists, low-cost sensors based on new smart materials and printing technologies offer a suitable solution. The results of multidisciplinary research thus far and proposals for the development of these devices have been presented by researchers from Czechia, Great Britain, Spain, and the USA in a review article in the prestigious journal <a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-026-68778-6#Abs1">Nature Communications</a>.“Sensor technologies for monitoring plant health are still in their infancy. Only simple sensors capable of monitoring basic parameters such as pH, soil moisture, or temperature are commonly available on the market. However, if farmers are to face current challenges, including climate change, and ensure sufficient food for humanity, they need much more effective tools that will enable them to monitor, for example, various pathogens, including bacteria and fungi. In our opinion, a suitable solution is a combination of new smart materials and printing for the production of inexpensive, durable, and scalable materials,” said the article’s first author, David Panáček from CATRIN, who worked on the study during his internship at Imperial College London.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg" alt="CATRIN: David Panáček" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg 208w," sizes="100vw" width="1536" height="1152">Sensors for monitoring plant health, for example, lag behind similar devices used in human medicine. According to the authors, advances in materials science, which will enable the development of scalable sensor technologies, play a key role in this potential shift. “Printing techniques, including inkjet printing, screen printing, aerosol printing, 3D printing, and direct laser writing, offer flexible ways to produce flexible sensors, large-area sensors, and sensors integrated directly into plants. The review article summarizes recent advances in printable low-dimensional materials for agricultural sensors, analyzes their physico-chemical properties in relation to sensor performance, and discusses key challenges and future opportunities requiring interdisciplinary integration,” said one of the corresponding authors, Michal Otyepka.The research brought together materials scientists, chemists, biologists, sensing experts, and printing technology specialists. Materials research and the use of graphene-based smart materials were led by scientists from CATRIN at Palacký University and VŠB-Technical University of Ostrava. Plant biologists from CATRIN contributed their knowledge of plant development, their responses to stress conditions, and the monitoring of their properties. Researchers from Imperial College London took care of the electronics, while representatives from<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/36"> CEITEC – VUT</a> focused on printing technologies. The team also included leading experts in sensing from the Catalan Institute of Nanoscience and Nanotechnology in Barcelona, and Joseph Wang of the University of California San Diego, the “father of sensing and electrochemistry,” also contributed his extensive knowledge.“This is a groundbreaking study on this topic, which has managed to attract some truly big names in their respective fields. Last but not least, the study demonstrates that interdisciplinarity at CATRIN gives rise to completely new and promising research topics, such as plant sensing and its use for studying plant-environment interactions and smart agriculture,” added another corresponding author, Nuria De Diego.

Current sensors are not good enough. Scientists propose a new way to monitor plant health

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The Multidimensional Chromatography (MDC) Workshop draws experts in this exciting field to share and discuss their research.

The Multidimensional Chromatography Workshop

The Czech Advanced Technology and Research Institute (CATRIN) at Palacký University is a cutting-edge scientific hub dedicated to advancing research in the fields of nanotechnology, biotechnology, and biomedicine. At its core, CATRIN boasts outstanding scientific teams, featuring international researchers. We emphasize interdisciplinarity, foster global collaborations, and work to translate our research findings into practical applications.

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Have you been wondering how the new features in the 8890 can help your lab? Do you know the new features the 8890 has to offer?
The 8890 has integrated tools that can help your lab with productivity. The new tools can also help your lab maintain, troubleshoot, and monitor your GC’s usage. Join this webinar to learn more about these features and find out how you can implement them in your lab.
<blockquote>
Presenter: Jamie Wetuski
</blockquote>

Agilent Technologies: Agilent 8890 Features to Improve Lab Productivity

Agilent 8890 Features to Improve Lab Productivity

Have you been wondering how the new features in the 8890 can help your lab? Do you know the new features the 8890 has to offer?

Traditional analytical workflows often involve sample preparation techniques requiring the use of large volumes of raw samples and organic solvents. The goal is to drive up recovery and sensitivity as it pertains to obtaining low levels of analyte detection.
Modern SPE technology has emerged to minimize sample and solvent consumption, while providing analytical sensitivity that is comparable to traditional workflows. The Biotage® MIKRO plate incorporates a common 96-well plate format for high throughput analysis and a robust, loosely packed 2 mg polymeric sorbent for the extraction of a variety of analytes.
Presented here is a brief overview of common but essential workflows in a microelution format, fully automated on the Biotage® Extrahera LV-200 sample preparation instrument. Workflows are simple, cost effective, and include discussions of drugs of abuse, steroids, catecholamines, and metanephrines.
<h5>Attendees will:</h5>
<ul>
<li>learn the unique differences between microelution and conventional SPE</li>
<li>better understand the application benefits of Mikro SPE</li>
<li>learn how to troubleshoot to improve analyte recovery</li>
<li>gain a direct comparison of the performance of traditional SPE workflow vs Mikro SPE automated workflow</li>
</ul>
<blockquote>
Presenter: Amber Cain (Application Scientist, Biotage)
</blockquote>
<blockquote>
Amber has 10 years of experience, largely involved in contract research organization work from bioanalytical pharmaceutical testing and metabolomics. She has extensive experience with SPE and other sample preparation techniques as well as LC-MS/MS.
</blockquote>

SeparationScience: The Might of MIKRO: Rethinking Routine Analytical Workflows through Volume Reduction and Solvent Consumption

The Might of MIKRO: Rethinking Routine Analytical Workflows through Volume Reduction and Solvent Consumption

An overview of common but essential workflows in a microelution format, fully automated on the Biotage® Extrahera LV-200 sample preparation instrument.

Analytical Workf. - Volume Reduction and Solvent Consumption

Cannabis testing focuses on harm reduction, by testing for unwanted pesticides, heavy metals and biological contamination. Cannabis and hemp products are tested just before being sold to consumers. While this single point testing mostly ensures the safety of the consumer, it does not safe the producer from process waste and product losses. In-process analytics is a valuable addition to cannabis and hemp production designs.
An IR Platform will be presented as a rapid, reliable and cheap platform for QC step.
<blockquote>
Presenter: Markus Roggen, PhD (President/CSO, Delic Labs)
</blockquote>
<blockquote>
Dr. Markus Roggen is President and Chief Scientific Officer of Delic Labs, a licensed cannabis and psilocybin research laboratory focused on extraction optimization, analytical testing, and process development. Delic Labs is one of a handful of research labs licensed for both cannabis and psilocybin in Canada. Dr. Roggen received his PhD in organic chemistry from the Federal Institute of Technology in Zürich (ETHZ). His research was recognized with numerous awards.
</blockquote>

Agilent Technologies: Cannabis & Hemp analysis with FTIR

Cannabis & Hemp analysis with FTIR

An IR Platform will be presented as a rapid, reliable and cheap platform for QC step.

During this webinar we will take a look at some of the latest trends and hot topics that are being observed within regulated laboratories. We will also discuss various processes that you need to implement in order to remain compliant with the latest regulatory guidance and minimize your inspection risk.
<h5>Specific topics that will be covered will include:</h5>
<ul>
<li>Custom Analytical Instrument Qualification (AIQ) based on User Requirement Specifications (URS)
</li>
<li>Repair Qualification (RQ)
</li>
<li>Hidden costs of Self-Qualification
</li>
<li>Computer System Validation (CSV)
</li>
</ul>
<blockquote>
Presenter: Garry Wright (European Laboratory Compliance Specialist, Agilent Technologies)
</blockquote>
<blockquote>
Garry Wright is the European Laboratory Compliance Specialist for Agilent Technologies and a member of the Agilent Compliance Council. Garry worked in Regulated Pharmaceutical industry for 20 years prior to joining Agilent.
</blockquote>
<blockquote>
His industrial experience focussed on development and implementation of Quality Management Systems, GMP training and Compliance Auditing. Garry’s role within Agilent is to provide Compliance Consulting services to Agilent and our customer network.
</blockquote>
<blockquote>
Garry has presented topics relating to Regulatory Compliance, Data Integrity and Instrument Qualification at a variety of Compliance forums over the last 7 years since joining Agilent.
</blockquote>

Agilent Technologies: How to Minimize Compliance Risk in Regulated Laboratories

How to Minimize Compliance Risk in Regulated Laboratories

During this webinar we will take a look at some of the latest trends and hot topics that are being observed within regulated laboratories.

With ever-increasing demands on your time, labor, and resources, optimizing your workflow is essential. Learn best approaches from GC-TOFMS experts to enhance your one- and two-dimensional gas chromatography applications (GC-MS and GCxGC-MS) in this collection of short webinars.
<h4>Switching to Hydrogen Carrier Gas</h4>
With an open ion source design, using hydrogen as a carrier gas for gas chromatography can save both time and money. Analyses are quicker, data quality is effectively the same, and a renewable hydrogen generator can slash the cost of helium. See examples of 1D and 2D method transfer, time savings, and real-life examples of data quality for various environmental and aroma applications in this webinar.
<h4>GC-MS Analysis Workflow</h4>
Small time savings throughout the workflow can add up to big savings. See aroma and flavor examples of how automated sample prep and elevated Time-of-Flight Mass Spectrometry (TOFMS) analysis, followed by software solutions to compare and evaluate data and results, can save your lab time and resources.
<ul>
<li>Part I: ChromaTOF® Sync for GC-MS Analysis</li>
<li>Part II: ChromaTOF Tile for GCxGC-MS Analysis</li>
</ul>
<h4>Discovery Workflow Best Practices</h4>
When you don&#39;t know what you&#39;re looking for, as is often the case with environmental contaminants and pollutants, the task can seem daunting, but high-resolution TOFMS and GCxGC is a powerful combination for non-target searches. With the tools included with the Pegasus® HRT+4D and the Multi-Mode Source™ (MMS™), identification of unknowns can be vastly improved and assigned higher confidence.

LECO: Enhanced GC-MS Workflow Solutions Webinar

Enhanced GC-MS Workflow Solutions Webinar

Learn best approaches from GC-TOFMS experts to enhance your one- and two-dimensional gas chromatography applications (GC-MS and GCxGC-MS).

The analysis of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) in food samples is a challenging application. Don´t miss this opportunity to ask our experts all your questions regarding the fully automated LC/GC workflow for MOAH/MOAH analysis.
We start with a brief introduction where we talk about upcoming changes in the legal requirements for MOSH/MOAH analysis. The remaining time is fully dedicated to your questions.
There are three ways to submit your questions:
<ul>
<li>Fill out the box on the webinar registration form</li>
<li>For more detailed questions, you can email us at: analyze.eu@thermofisher.com</li>
<li>Ask your questions on the day using the chat function during the live session</li>
</ul>
Of course you are welcome to join even if you don´t have a specific question, so you can pick up useful information and build up expertise.
<blockquote>
Presenter: Jeroen Weyts (SampleQ Analytical Support GC-MS, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Presenter: Jorn Hofsteenge (SampleQ Analytical Support GC)
</blockquote>
<blockquote>
Presenter: Inge de Dobbeleer (Sample Q Account Manager)
</blockquote>
<blockquote>
Presenter: Petra Gerhards (Regional Marketing Manager for GC &amp; GC-MS, EMEA, Thermo Fisher Scientific)
</blockquote>

Thermo Fisher Scientific: Ask-the-experts session on MOSH/MOAH analysis

Ask-the-experts session on MOSH/MOAH analysis

Don´t miss this opportunity to ask our experts all your questions regarding the fully automated LC/GC workflow for MOAH/MOAH analysis.

How do you know if your peak is “pure”? How do you know if your sample conforms to your gold standard? OpenLab CDS provides the tools to answer these questions. This seminar will show you how.
<blockquote>
Presenter: Richard Mutkoski (Laboratory Informatics Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Richard Mutkoski has been a field representative for over 27 years for both hardware and software. In his current role as an Informatics Application Engineer, Rich presents technical solutions of the OpenLab suite of products to customers worldwide. Prior to his tenure at Agilent Rich spent 15 years in a variety of Pharma QA/QC and R&amp;D positions providing him a unique understanding of those workflows, bottlenecks and challenges.
</blockquote>

Agilent Technologies: Save Time Using the New Integration Optimizer in OpenLab CDS

Save Time Using the New Integration Optimizer in OpenLab CDS

How do you know if your peak is “pure”? How do you know if your sample conforms to your gold standard?

Polarizers are a common accessory on UV-VIS-NIR spectrometers. Though not needed for every measurement, there are certain common experiments where it is important to have one.
We will discuss in this presentation how polarizers operate in the spectrometer and some examples of when they are needed for transmission and reflection spectroscopy.
<blockquote>
Presenter: Scott Melis, PhD (Application Scientist, Agilent Technologies, Inc.)
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<blockquote>
Scott Melis has a PHD in Physics from Georgetown University in Washington, DC and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications. Projects that he worked with include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.
</blockquote>

Agilent Technologies: When Do I Need a Polarizer on my UV-Vis-NIR?

When Do I Need a Polarizer on my UV-Vis-NIR?

We will discuss how polarizers operate in the spectrometer and some examples of when they are needed for transmission and reflection spectroscopy.

Do you regularly perform quality control or product screening of polymers? Then you know that this task usually requires several different technologies to determine critical parameters such as density, intrinsic viscosity, hydroxyl value, melt flow index, and more
In our upcoming webinar, Maria Angeles Cartes Dominguez and Wim Guns, both from Metrohm, present an alternative method for routine QC and screening of polymers. 
This multi-parameter approach is based on Near-Infrared Spectroscopy (NIRS) and allows manufacturers and processors to determine multiple chemical and physical QC parameters all at the same time, in less than a minute, and without any sample preparation required. In fact, NIRS has been proven a solution that helped some of our customers to reduce the costs of their routine QC of polymers by up to 90%. Register for this webinar and learn:
<ul>
<li>What NIRS is and how this technology works</li>
<li>How NIRS compares to traditional wet chemistry</li>
<li>How NIRS is applied as per ASTM guidelines</li>
<li>Application examples for NIRS from the polymer sector</li>
</ul>
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Presenter: Wim Guns (International Sales Support, Metrohm International Headquarters)
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Wim Guns is based in The Netherlands and has a degree in chemical engineering. After 20 years of involvement with NIRS for FOSS, Wim joined the Metrohm organization in 2013. Wim is responsible for NIRS sales support and second line support for all Metrohm affiliates and distributors.
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Presenter: Maria Angeles Cartes Dominguez, PhD (Product Specialist Spectroscopy, Metrohm International Headquarters)
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<blockquote>
Dr. Maria Cartes studied Chemistry. After finishing her PhD studies on ethylene polymerization at the University of Seville (Spain), she moved to Switzerland to work there as a Post-doc. In the beginning of 2021 Maria joined Metrohm where she works as Product Specialist spectroscopy at the Competence Center Spectroscopy, providing NIRS international support and product training.
</blockquote>

Metrohm: NIRS for polymers – a faster solution for product screening and QC

NIRS for polymers – a faster solution for product screening and QC

In our upcoming webinar, Maria Angeles Cartes Dominguez and Wim Guns, both from Metrohm, present an alternative method for routine QC and screening of polymers.

NIRS for polymers – solution for product screening and QC

The growing demand for battery production has increased the importance for battery manufacturers to ensure that production workflows are efficient and cost-effective. With the complexity of battery manufacturing workflows, there is a high-value need to ensure that the performance and safety of pre-production testing of raw materials, in-process monitoring of intermediate components, and end-products meets specific industry standards.
With the support of a modern laboratory information management system (LIMS), an organization can centrally organize the data generation through battery quality management workflows, and successfully access, analyze, and share data and information to increase time and efficiency. Implementing a LIMS can aggregate data in a meaningful way, seamlessly share that data, and drive insightful decision-making. With the right informatics tools to support production, battery manufacturers can build a strong foundation for improved quality and efficiency making sure that industry standards are met.
Attend this presentation to...
<ul>
<li>discover how LIMS can improve traceability, data integrity, and efficiency in battery cell manufacturing workflows</li>
<li>learn what the benefits of implementing a LIMS into your battery manufacturing organization today would be.</li>
</ul>
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Presenter: Tareq Al-Najjar (Global Strategic Account Executive, Energy – Digital Science Solutions, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Tareq has extensive experience identifying, establishing, and expanding market/product presence in the oil, gas, and energy arenas. With his most recent experience as the VP of International Business Development/Investor Relations at Vacom Systems LLC from 2015–2022, Tareq joined the Thermo Fisher Scientific team in February 2022 to bring his expertise into the LIMS sector. Tareq has a Bachelor of Science Degree in Electrical and Computer Engineering from the University of Utah and a Master of Business Administration (MBA) from the University of Utah David Eccles School of Business.
</blockquote>

Separation Science: How LIMS can benefit battery manufacturing workflows

How LIMS can benefit battery manufacturing workflows

An upcoming presentation outlining the benefits of implementing a laboratory information management system into battery cell manufacturing workflows.