🎤 Presenter: Christopher Freye (Los Alamos National Laboratory)💾 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_1_Freye_10783a9cf3.pdf">PDF presentation</a><h3>Abstract</h3>Two-dimensional gas chromatography (<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?instrumentationItems=2">GC×GC</a>) when coupled with mass spectrometry (MS) especially high-resolution mass spectrometry (HRMS) provides the ideal technique to discover minute chemical changes. However, GC×GC analyses result in extremely large datasets (GBs of information) wherein the statistically significant chemical changes are buried within the background chemical matrix. To combat these issues, many chemometric techniques have been developed or applied. Recently we introduced a new chemometric technique for GC-MS termed alteration analysis (ALA) and two-dimensional correlation (2DCOR) which can be used to discover statistically significant chemical changes across a series of chromatograms and understand the relationship between the statistically relevant changes. ALA generates three sets of information, the basic alteration map (BAM) which is the magnitude of the change, the synchronous alteration map (SAM) which describes the linear change, and the asynchronous alteration map (AAM) which describes the non-linear change. 2DCOR can then be used to understand the relationship between the chemical changes but 2DCOR can also resolve the sequence of the changes. A workflow for GC×GC-MS will be demonstrated. Special attention will be given to what differentiates the GC×GC work flow from GC for both the ALA and 2DCOR.<h3>Video Transcription</h3>The presentation focuses on how advanced mathematical and chemometric methods can be used to extract meaningful information from highly complex chromatographic data, especially in multidimensional chromatography coupled with mass spectrometry (GC×GC-MS, LC-MS).<h4>Why traditional data analysis falls short</h4>Modern multidimensional chromatography generates extremely large datasets, often containing billions of data points. Visual inspection, peak tables, or classical identification-based workflows are impractical—especially when:<ul><li>Samples are highly complex (e.g. petroleum, metabolomics, high explosives)</li><li>Most compounds are unknown unknowns</li><li>The key question is not what the compounds are, but whether samples differ and how</li></ul>Program managers and decision-makers are primarily interested in detecting statistically significant changes, not exhaustive compound identification.<h4>Introduction of Alteration Analysis (ALA)</h4>To address subtle, trend-based changes across series of chromatograms, the speaker introduces Alteration Analysis (ALA), a chemometric approach adapted from spectroscopy and applied to chromatography.ALA quantitatively evaluates how individual data points change across multiple samples, allowing detection of:<ul><li>Extremely subtle trends</li><li>Overlapping peaks</li><li>Changes hidden in noise or baseline interference</li></ul>Key ALA outputs include:<ul><li>BAM (Basic Alteration Map): magnitude of change</li><li>SAM (Systematic Alteration Map): linear changes</li><li>AM (Alteration Map): nonlinear changes</li></ul>Even changes as small as 1% per sample can be detected reliably, including peaks that are heavily overlapped.<h4>Beyond detection: understanding relationships with 2D Correlation</h4>Once statistically significant changes are identified, two-dimensional correlation analysis (2D-COR) is used to understand relationships between changing compounds, including:<ul><li>Whether compounds are correlated or anti-correlated</li><li>The sequence of changes over time (which changes happen first)</li></ul>This is especially critical for degradation and aging studies, where intermediate species may appear and disappear before the final state—information that traditional methods like Fisher ratio or PCA often miss.<h4>Solving GC×GC challenges with tiling</h4>GC×GC data introduces additional challenges due to:<ul><li>Peak misalignment</li><li>Exponential data growth during correlation calculations</li></ul>The presenter explains how tile-based approaches reduce data dimensionality, overcome alignment issues, and make ALA and 2D correlation computationally feasible—even for massive GC×GC-MS datasets.<h4>Real-world application: explosive aging studies</h4>The methodology was applied to aging and decomposition of high explosives, where:<ul><li>Over 250 chemical changes were identified</li><li>Many intermediate species would have been missed using traditional comparisons</li><li>ALA combined with 2D correlation enabled reconstruction of degradation pathways</li><li>The most significant change was not necessarily the first change, a critical insight for risk assessment and stability studies</li></ul><h4>Key takeaway</h4>By combining Alteration Analysis and 2D correlation, the approach:<ul><li>Detects statistically guaranteed chemical changes</li><li>Handles subtle, overlapped, and noisy signals</li><li>Determines magnitude, type, interrelationships, and order of changes</li><li>Shifts chromatographic data analysis from identification-driven to decision-driven</li></ul>This math-driven workflow enables faster, more reliable interpretation of complex chromatographic datasets and provides actionable insights for applications such as explosive aging, pharmaceutical degradation, and complex mixture analysis.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote>

Discovery analysis for GCxGC trends using alteration and 2D correlation (Chris Freye, MDCW 2026)

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 9th February 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you technical note by Agilent Technologies, presentation by MDCW / University of Copenhagen and application notes by Shimadzu and Thermo Fisher Scientific!<h3>1. Agilent Technologies: What Causes Spots on <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?instrumentationItems=19&amp;manufacturerItems=1&amp;search=PLOT">PLOT Columns</a>? Will It Affect the Performance of the Column?</h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_what_causes_spots_plot_columns_affecting_performance_5994_8775en_agilent_3b7180512a.pdf">Full PDF for download</a></li></ul>Spots on porous layer open tubular (PLOT) columns are caused by small voids in the stationary phase coating inside the tube. These spots are areas where there is an uneven coating or lack of phase. It is normal to find some voids in the phase coating of PLOT columns. The stationary phase in PLOT columns is an opaque, solid, and porous material. In many Agilent PLOT columns such as the GS-Alumina phases, molecular sieves, porous polymers (Q and U), and the GS-OxyPLOT, the stationary phase is visible as a white powder. For many PLOT columns, the stationary phase fill solution is a viscous suspension of particles that are less than 10 microns in diameter. The phase is coated using a dynamic process in which a plug of fill solution is pushed through the tubing, and the plug’s speed and viscosity determines the thickness of the stationary phase layer. Once the PLOT’s stationary phase is deposited, it is held in place by electrostatic charge, chemical interactions between particles, and/or binding agents. In wall‑coated open tubular (WCOT) columns, stationary phases such as polysiloxanes or polyethylene glycols are immobilized by chemical bonding to the glass surface and cross-linking between polymer strands. Because this type of bonding and cross‑linking is not possible with PLOT phases, the result is a stationary phase layer that is both fundamentally different and inherently less stable in PLOT columns than in WCOT&nbsp;columns.<h3>2. MDCW / University of Copenhagen: One-shot tensor decomposition of full-scale GC×GC-VUV datasets for resolving petrochemical groups</h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_17_Schneide_67c8ff7866.pdf">Full PDF for download</a></li></ul>The presentation introduces a novel all-samples-at-once, shift-invariant tri-linear tensor decomposition approach for the analysis of full-scale <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?search=GC%C3%97GC-VUV">GC×GC-VUV</a> datasets, aimed at resolving and quantifying petrochemical groups. Traditional template-based or pixel-based methods struggle with retention-time shifts and co-eluting compounds, often requiring manual intervention and prior chemical knowledge. The proposed approach leverages the intrinsic low-rank structure of GC×GC-VUV data to enable robust, automated group-level analysis across multiple samples simultaneously.At the core of the method is a shift-invariant tri-linear model, conceptually related to PARAFAC and multivariate curve resolution, but extended using frequency-domain (FFT-based) modeling to explicitly account for chromatographic peak shifts. By decomposing the entire dataset in one step, the model provides accurate estimates of peak landscapes, VUV spectra, and relative peak areas, while remaining agnostic to retention-time variability. Importantly, the approach requires only a small number of tunable parameters, making it practical for routine use.The method was demonstrated on a case study involving 14 petrochemical gas-oil samples, including straight-run, hydrotreated, hydroconverted, coker, and light cycle oils. Extracted VUV spectra showed excellent agreement with reference spectra from a VUV spectral database, enabling confident assignment of components to chemical groups such as saturates, olefins, and mono- to poly-aromatics. Quantitative results exhibited high repeatability (RSD typically 3–9%) and strong correlation with established template-based reference methods.Overall, the work demonstrates that one-shot, shift-invariant tensor decomposition provides a powerful and scalable alternative to conventional GC×GC data-analysis strategies. By combining chemical interpretability, robustness to chromatographic shifts, and strong quantitative performance, the approach opens new opportunities for automated, high-confidence group-level analysis of complex petrochemical samples and beyond.<h3>3. Shimadzu: Py-Screener Ver. 3: Simultaneously Test for Substances Regulated Under RoHS, TSCA, and POPs</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00949_en_4754e50164.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>In just one analysis, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=Py-Screener">Py-Screener</a> Ver. 3 can determine levels of phthalate esters, brominated flame retardants (PBBs, PBDEs), PIP (3:1), UV-328, dechlorane plus (DP), short-chain chlorinated paraffins (SCCPs), and medium-chain chlorinated paraffins (MCCPs).&nbsp;</li><li>It can also test for SCCPs and MCCPs by electron ionization (EI) instead of negative chemical ionization (NCI).&nbsp;</li><li>PIP (3:1), UV-328, DP, and SCCPs and MCCPs can be screened without the need for corresponding reference materials.</li></ul>Countries and regulatory bodies worldwide are introducing increasingly stringent regulations on the chemical substances used in electronic devices and industrial products. The RoHS Directive and REACH regulations in the EU, the Toxic Substances Control Act (TSCA) in the USA, and the Stockholm Convention on Persistent Organic Pollutants (POPs) are also targeting an increasingly broad range of substances. Therefore, manufacturers are required to accurately identify regulated substances in their products and comply with each regulation. While Py-Screener Ver. 2 can screen for seven phthalate esters and brominated flame retardants, including substances regulated under the RoHS Directive, version 3 can also screen for PIP (3:1), which is regulated under the TSCA, as well as UV328, DP, and SCCPs and MCCPs , which are regulated under the Stockholm Convention on POPs. A list of supported substances isshown in Table 1. This article introduces the simultaneous analysis of multiple regulated substances and a case study of testing specific regulated substances in samples, using Py-Screener Ver. 3.<h4>Analysis Process</h4>Py-Screener Ver. 3 can determine levels of phthalate esters and brominated flame retardants contained in products in accordance with the international analytical standards IEC62321-8 and IEC62321-3-3. It can also test for specific regulated substances (Table 1) under the same conditions and in the same analysis. In this test, background intensity and instrument sensitivity (S/N) were verified before analyzing samples. These parameters are prescribed by IEC62321-8 to ensure the accuracy of the methods used. Background intensity and instrument sensitivity were determined using a reference material (PN: 225-31003- 91) *1 that consisted of a plastic sheet that was spiked with seven phthalate esters. The results met the criteria for both parameters.The testing workflow is shown in Fig. 1. Before testing samples, calibration curves were prepared by analyzing the 1000 mg/kg phthalate ester reference material and polypropylene spiked with brominated flame retardants (ERM-EC591). A hole puncher was used to punch out two discs at a time of the phthalate ester reference material, and a cutter was used to obtain pieces of the other materials. Each material was weighed in a sample cup for analysis. During the analysis of samples, phthalate esters and some of the regulated brominated flame retardants were quantitated using a one-point calibration curve. The remaining brominated flame retardants and specific regulated substances were quantitated using the correction factor database*2 that is included with Py-Screener Ver. 3.<h4>Conclusion</h4>Py-Screener Ver. 3 successfully determined in samples the concentrations of the regulated substances PIP (3:1), UV-328, DP, and SCCPs and MCCPs. Normally, SCCP and MCCP levels are tested using NCI, but Py-Screener Ver. 3 uses EI. This enables it to test for not only SCCPs and MCCPs but also phthalate esters, brominated flame retardants, and other regulated substances in just one analysis. In addition, by using the relative correction factors linked to DEHP in the phthalate ester reference material, the levels of these regulated substances were determined without the need for the corresponding reference materials. Py-Screener Ver. 3 can also create a screening program that addresses substance restrictions under the RoHS Directive, the US TSCA, and the POPs Convention.<h3>4. Thermo Fisher Scientific: Improving low carbon steel production in specialty steel processes</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/prima_pro_process_mass_spectrometer_an1626_7fc840235f.pdf">Full PDF for download</a></li></ul>World crude steel production reached 1,691 million tonnes in 2017, up by 5.3% compared to 2016.1 While much of this capacity is still produced in primary steel processes such as basic oxygen furnaces and electric arc furnaces, the need for refined steel with greater durability and resistance to heat and corrosion has led to the increased use of vacuum degassing processes, such as VOD and RH, in secondary steel production. These processes are able to achieve ultra-low levels of residual carbon, while at the same time retaining desired levels of other alloy materials. If these processes are to achieve the required level of steel product quality, they need fast, continuous gas analysis of the furnace exhaust gas. Without accurate information on the composition of the gas leaving the furnace, any variations in the decarburization process are only detected after the event, resulting in the production of out-of-specification steel.<h4>Advantages of mass spectrometry&nbsp;</h4>Traditional Non-Dispersive Infra-Red (NDIR) analyzers are used in many conventional steelmaking processes to measure CO and CO2 , but they can only sample at atmospheric pressure. In vacuum steelmaking the process pressure changes dramatically, typically from atmospheric pressure down to less than 1 mbar, over the 20-30 minutes of the melt. So NDIR analyzers have to sample some distance downstream from the process. Analytical data is updated several minutes after the gas leaves the melt and the control system is forced to operate on historic rather than real-time data.&nbsp;Paramagnetic analyzers can be used to measure O2 , while thermal conductivity analyzers can be used to measure H2 . These analyzers also suffer from slow response, while the need to operate three different types of analyzers adds to the plant maintenance burden. Moreover, the three analyzers cannot analyze inert gases, so N2 is calculated by difference, a result that suffers from the sum of the errors of the three analytical techniques.&nbsp;Mass spectrometry operates at high vacuum so it is ideal for monitoring vacuum processes. It is also able to monitor all seven components in Table 1 in seconds rather than minutes, ensuring the plant control model is frequently updated with accurate compositional data.<h4>Precision of analysis&nbsp;</h4>At the heart of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=Prima+PRO+Mass+Spectrometer">Thermo Scientific™ Prima PRO Mass Spectrometer</a> (MS) is a magnetic sector analyzer which offers unrivalled precision and accuracy compared with other mass spectrometers. Thermo Fisher Scientific manufactures both quadrupole and magnetic sector mass spectrometers; over thirty years of industrial experience have shown the magnetic sector based analyzer offers the best performance for industrial on-line gas analysis.&nbsp;Key advantages of magnetic sector analyzers include improved precision, accuracy, long intervals between calibrations, and resistance to contamination. Typically, analytical precision is between 2 and 10 times better than a quadrupole analyzer, depending on the gases analyzed and complexity of the mixture.&nbsp;A unique feature of the Prima PRO magnet is that it is laminated. Its analysis times are similar to a quadrupole analyzer, offering the unique combination of rapid analysis and high stability. This allows the rapid and extremely stable analysis of an unlimited number of user-defined gases. The scanning magnetic sector is controlled with 24-bit precision using a magnetic flux measuring device for extremely stable mass alignment.&nbsp;The ion source is an enclosed type for high sensitivity, minimum background interference, and maximum contamination resistance. This is a high-energy (1000 eV) analyzer that offers extremely rugged performance in the presence of gases and vapors that have the potential for contaminating the analyzer. Typical performance specifications for the Prima PRO MS are shown in Table 1. Analytical performance is demonstrated by analyzing the calibration bottle over 1 hour following calibration, with an analysis time of just 6 seconds. Standard deviations measured on the calibration cylinder will be equal to or better than the stated values.

News from LabRulezGCMS Library - Week 07, 2026

Although modern agriculture needs to be based on accurate real-time data on soil, plant, and environmental conditions, affordable, sufficiently sensitive, and robust monitoring devices for this purpose are currently missing. According to scientists, low-cost sensors based on new smart materials and printing technologies offer a suitable solution. The results of multidisciplinary research thus far and proposals for the development of these devices have been presented by researchers from Czechia, Great Britain, Spain, and the USA in a review article in the prestigious journal <a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41467-026-68778-6#Abs1">Nature Communications</a>.“Sensor technologies for monitoring plant health are still in their infancy. Only simple sensors capable of monitoring basic parameters such as pH, soil moisture, or temperature are commonly available on the market. However, if farmers are to face current challenges, including climate change, and ensure sufficient food for humanity, they need much more effective tools that will enable them to monitor, for example, various pathogens, including bacteria and fungi. In our opinion, a suitable solution is a combination of new smart materials and printing for the production of inexpensive, durable, and scalable materials,” said the article’s first author, David Panáček from CATRIN, who worked on the study during his internship at Imperial College London.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg" alt="CATRIN: David Panáček" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Soucasne_senzory_nestaci_Vedci_navrhuji_novou_cestu_ke_sledovani_zdravi_rostlin_b4014952a3.jpg 208w," sizes="100vw" width="1536" height="1152">Sensors for monitoring plant health, for example, lag behind similar devices used in human medicine. According to the authors, advances in materials science, which will enable the development of scalable sensor technologies, play a key role in this potential shift. “Printing techniques, including inkjet printing, screen printing, aerosol printing, 3D printing, and direct laser writing, offer flexible ways to produce flexible sensors, large-area sensors, and sensors integrated directly into plants. The review article summarizes recent advances in printable low-dimensional materials for agricultural sensors, analyzes their physico-chemical properties in relation to sensor performance, and discusses key challenges and future opportunities requiring interdisciplinary integration,” said one of the corresponding authors, Michal Otyepka.The research brought together materials scientists, chemists, biologists, sensing experts, and printing technology specialists. Materials research and the use of graphene-based smart materials were led by scientists from CATRIN at Palacký University and VŠB-Technical University of Ostrava. Plant biologists from CATRIN contributed their knowledge of plant development, their responses to stress conditions, and the monitoring of their properties. Researchers from Imperial College London took care of the electronics, while representatives from<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/36"> CEITEC – VUT</a> focused on printing technologies. The team also included leading experts in sensing from the Catalan Institute of Nanoscience and Nanotechnology in Barcelona, and Joseph Wang of the University of California San Diego, the “father of sensing and electrochemistry,” also contributed his extensive knowledge.“This is a groundbreaking study on this topic, which has managed to attract some truly big names in their respective fields. Last but not least, the study demonstrates that interdisciplinarity at CATRIN gives rise to completely new and promising research topics, such as plant sensing and its use for studying plant-environment interactions and smart agriculture,” added another corresponding author, Nuria De Diego.

Current sensors are not good enough. Scientists propose a new way to monitor plant health

Article

Application

Video

Presentation

Scientific article

Science and research

The Multidimensional Chromatography (MDC) Workshop draws experts in this exciting field to share and discuss their research.

The Multidimensional Chromatography Workshop

The Czech Advanced Technology and Research Institute (CATRIN) at Palacký University is a cutting-edge scientific hub dedicated to advancing research in the fields of nanotechnology, biotechnology, and biomedicine. At its core, CATRIN boasts outstanding scientific teams, featuring international researchers. We emphasize interdisciplinarity, foster global collaborations, and work to translate our research findings into practical applications.

CATRIN

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Agilent Technologies

Thermo Fisher Scientific

SelectScience

Shimadzu Corporation

Waters Corporation

<h5>Session 1: Milk adulteration</h5>
There are so many food frauds that are a threat to consumers. Learn about a complete GC based solution on how to detect adulteration in milk. We will also cover workflows using ion chromatography to profile milk glycans, lactose and carbohydrates to ensure quality products.
<h5>Session 2: Mineral oil saturated hydrocarbons and aromatic hydrocarbons (MOSH/MOAH)</h5>
A 10 year old topic that is still the focus of chemists all over the world. Here, a fully automated solution will be presented, based on the LC/GC technique that is widely used in this field.
<blockquote>
Presenter: Daniela Cavagnino (Product Marketing Manager, GC and Autosampler and Applied Technologies, Thermo Fisher Scientific)
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Daniela Cavagnino received the master’s degree in chemistry at the University of Milan, Italy. She started her career in gas chromatography at Thermo Fisher Scientific spending several years in the R&amp;D laboratories working on GC technology innovation. Then, she conveyed her technical background into product management and marketing management roles with more than 10 years’ experience in promoting GC/GC-MS technology and applications in several different market segments.
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<blockquote>
Presenter: Jorn Hofsteenge (Analytical Support Specialist, Interscience BV, Netherlands)
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Jorn is currently working withInterscience BV, Netherlands as an analytical specialist. He is a graduate in chemistry with specialization in forensic chemistry. He has around 10 years of experience and possesses a wide range of knowledge and skills in the fields of analytical chemistry and organic chemistry.
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<blockquote>
Presenter: (Wai-Chi Man, Product Marketing Manager, IC/SP, Thermo Fisher Scientific)
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Recently moved into Product Marketing from Application Sales Support role within ThermoFisher Scientific but was a customer.
</blockquote>
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Specialised in Ion Chromatography (IC) for over 32 years with 35 years in Analytical Chemistry experience in a wide range of techniques (IC, LC, GC, CE, MS, NMR, ICP, FTIR etc). Spent 7 Years at Wellcome Research supporting Structural Elucidation for Medicinal Chemists using a wide range of analytical instrumentation. A total of 20 Years in the Pharma industry as part of GlaxoSmith Kline, from Research to transferring methods to Manufacturing. Worked on and responsible for many drugs from anti-viral to respiratory.
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Have been working for ThermoFisher Scientific since 2011 working with a wide range of customers from varies industry, providing ion chromatography support in method development, troubleshooting, sample preparation, trainings, seminars, events and workshops. Within this time, I have built a greater knowledge, skill and understanding within varies areas in IC such as IC-MS, IC-ICP-MS, HPAE-PAD analysis, metabolomics and polar pesticides.
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I am passionate in promoting STEM (Science Technology Engineering Mathematics) to future Scientists by encouraging, nurturing and supporting them.
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Thermo Fisher Scientific: Emerging Topics in Food Safety

Food integrity and QC

Webinar will cover topics like Milk adulteration or Mineral oil saturated hydrocarbons and aromatic hydrocarbons (MOSH/MOAH) analysis.

<h5>Session 1: Beer off flavours</h5>
What would you do if suddenly the taste of your beer was different? This is a big issue for manufacturers and where GC-MS analysis can help. 
<h5>Session 2: Beer Integrity and quality</h5>
Beer, malt and wort testing is essential to producing a quality product, off flavours are the way to turn your customers off your products. Many of the tests performed on beer samples can require multiple analyzers, but there is another way to analyze multiple parameters at the same time.
The Thermo Scientific Gallery Plus Beermaster discrete analyzer can deliver reliable analyses for multiple tests such as bitterness, acidity and sugar content—all from a single sample and run up to 350 tests per hour. This system’s automated workflow and fast analysis work together to ensure high throughput and low cost-per-test. Because the instrument operates without manual intervention, your staff can enjoy walkaway productivity and focus on more strategic tasks in the lab. More testing, from fewer instruments and with fewer techs.
This webinar will show how you can work smarter and ensure the quality of your product.
<h3>Who should attend:</h3>
<ul>
<li>Lab managers and analysts that have analytical challenges when testing food and beverages</li>
<li>QA/QC and research laboratories that want to keep up to date and also be ready for future challenges</li>
<li>Lab leaders who want to leverage the full analytical potential of their analytical instrumentation</li>
<li>Scientists/chemists/analysts interested in using isotope fingerprints for food analysis</li>
</ul>
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Presenter: Spencer Britton (Senior Quality Lab Specialist, Creature Comforts Brewing Company, Athens)
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Spencer Britton is a Senior Quality Lab Specialist at Creature Comforts Brewing Company in Athens, GA. Before joining the brewing industry in May 2017, he worked in a biopharmaceutical laboratory focusing on protein chemistry and ELISA development. Spencer is passionate about ensuring quality products and practices, which has led him to collaborate across the brewing industry to help establish key testing protocols.
</blockquote>

Food integrity and QC - Maintaining quality in the brewing process

This webinar will show how you can work smarter and ensure the quality of your product. Topics like Beer off flavours or Beer Integrity and quality.

Food integrity - Maintaining quality in the brewing process

Automation series: The #ConnectedLaboratory is real!
Have you joined the &quot;Meet the #ConnectedLaboratory&quot; series last year? If not have a look <a href="https://lcms.labrulez.com/webinars?search=%23ConnectedLaboratory&amp;tags=5">@Meet the #ConnectedLaboratory</a> to learn how easy it can be to get back some of your valuable time or complement your existing automation solutions in a flexible way.
Ready to take the next step? Learn how OneLab can become your sample preparation partner, get access to liquid handling tips &amp; tricks, be the first to learn about the newest additions and learn from your peers, sharing their experience implementing the #ConnectedLaboratory.
<h3>Part 4: Meet your peers and see how they implemented the #ConnectedLaboratory</h3>
Hear how existing users have implemented the #ConnectedLaboratory.
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Presenter: Evelien Dejaegere (Marketing Manager Chemistry EMEA, Waters Corporation)
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Evelien joined Waters in 2005 and is currently a Marketing Manager in the European Chemistry organization. She is passionate on leveraging products and solutions to solve analytical challenges &quot;from sample to result&quot; with the aim to help advancing science and basically make our world a better place.
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Recently, Evelien has a focus on laboratory automation workflows, helping customers turn samples into results with robustness, reliability and reproducibility. Involved with product development and commercialization, Evelien is keenly interested in learning about the challenges faced in the analytical laboratory, in order to facilitate the development of enabling technologies.
</blockquote>

Waters Corporation: Automation series The #ConnectedLaboratory is real!

The #ConnectedLaboratory is real! - Part 4: Meet your peers and see how they implemented the #ConnectedLaborator

Hear how existing users have implemented the #ConnectedLaboratory.

Meet your peers. Implementation the #ConnectedLaboratory

Quality is imperative throughout the entire development, validation, and final release testing of any therapeutic product. Often involving many complex and multifaceted challenges, vendors have a responsibility to ensure that their products meet defined criteria to deliver reliability and peace of mind to the end user.
In this online seminar series, software specialists will discuss how a modern chromatography data system (CDS) can provide a secure software platform from its early design, offering all the tools you need to maintain the integrity of your data, while alleviating concerns associated with regulatory audits.
If you would like to attend a webinar but are unable to join live, please do still register as all registrants will receive an on-demand link which you can use to watch the webinar after the live date.
<h3>Webinar 3. Ensuring system quality to deliver easier audits</h3>
<ul>
<li>Find out how you can prepare for an inevitable audit</li>
<li>Learn about current regulatory requirements and what this means for your lab</li>
<li>Discover expert hints and tips for an effective system review</li>
</ul>
<blockquote>
Presenter: Patrick Kenny (Software Compliance Product Manager, Thermo Fisher Scientific)
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Patrick Kenny holds BS and MS degrees in chemistry from the University of Massachusetts Dartmouth and University of Massachusetts Amherst. Kenny spent 13 years in management and director roles in pharmaceutical laboratories. In these roles, he represented the chemistry lab in FDA, EMA, ISO, QP and customer audits. Kenny’s extensive regulated-lab management experience gives him a unique insight into the challenges lab managers face on a daily basis. He uses this knowledge to help customers best utilize their software to achieve regulatory compliance while realizing high productivity.
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Ensuring system quality to deliver easier audits

Find out how you can prepare for an inevitable audit. Learn about current regulatory requirements and what this means for your lab.

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Presenter: Bryan White (Agilent Technologies)
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Agilent Technologies: Strategies to Mitigate for Rising Helium Gas Costs

Strategies to Mitigate for Rising Helium Gas Costs

This webinar describes analytical methods used for screening of extractables and leachables (E&amp;L) in pharmaceutical packaging and product.
Extractables analysis was performed by Direct TD-GCMS, while leachables by liquid injection-GCMS. Identification was carried out using NIST 14 Library and Shimadzu Polymer Additives Library. Instead of time-consuming solvent extraction procedure, a simpler Direct Thermal Desorption technique is used to perform extraction of the extractable compounds from polymer packaging. The result of extractables is compared with leachables analysis result from the product contained in the packaging.
Learning Objectives:
<ul>
<li>To provide a general knowledge of Extractables and Leachables
</li>
<li>To provide a simpler solution to E&amp;L screening
</li>
</ul>
<blockquote>
Presenter: Cynthia Lahey (Assistant Manager, Shimadzu (Asia Pacific) Pte Ltd)
</blockquote>
<blockquote>
Cynthia started working with GC and GCMS in Shimadzu (Asia Pacific) in 2003, including various techniques such as headspace, SPME, thermal desorption and pyrolyzer. She has delivered numerous GC &amp; GCMS training courses, participated in international seminars, workshops and conferences as well as developed application notes for Shimadzu (Asia Pacific).
</blockquote>

Shimadzu: E&L Screening in Pharma Packaging and Product by GCMS

E&L Screening in Pharma Packaging and Product by GCMS

Analytical methods used for screening of extractables and leachables (E&L) in pharmaceutical packaging and product.

The COVID-19 pandemic has brought unprecedented challenges for the communities and economies worldwide, causing a profound effect on the lives of billions of people.
While government and communities are trying to contain the spread, researchers are aggressively focusing their efforts towards finding a treatment and/or vaccine. Science is more important now than ever before.
This webinar will feature the current analytical technologies and solutions that Shimadzu is committed to provide – such as analytical techniques for drug testing and vaccine research, production and testing of sanitizers and personal protective equipment and analysis of medical sewage waste.
<h5>Learning Objectives:</h5>
<ul>
<li>Comprehensive workflow for Pharma, PPE manufacturing and Environmental monitoring
</li>
<li>Explore solutions accelerating research
</li>
<li>Informatics workflows enabling remote operations and monitoring
</li>
</ul>
<blockquote>
Presenter: Sandhya (Sandy) Nargund (Deputy General Manager, Shimadzu (Asia Pacific) Pte. Ltd.)
</blockquote>
<blockquote>
Sandy has over 22 years’ experience in Analytical field with various roles starting from Pharma QC to Mass Spectrometry expert in supporting advance MS technologies. Sandy has wide experience on Mass Spectrometry while working as ‘Application Specialist’ and has conducted many users training and workflow trainings for small molecules and proteomics using LC-MS/MS, GC-MS/MS and High-resolution MS. She is currently working as Deputy General Manager in Shimadzu Asia Pacific, Singapore and is responsible for managing and promoting Shimadzu&#39;s analytical products range including Spectroscopy, Chromatography and Mass Spectrometry in region and to provide technical support on various applications in food safety, Pharma, Clinical and other markets.
</blockquote>
<blockquote>
Presenter: Jackie (Product Specialist (GC &amp; GCMS), Shimadzu (Asia Pacific) Pte. Ltd.)
</blockquote>
<blockquote>
After graduating from the National University of Singapore, Jackie has garnered over 6 years of research, training and facilitation experience. Jackie meets scientists from various industries to share technical knowledge and collect feedback, understanding their problems and helping them find well-suited solutions in GC-related analyses.
</blockquote>

Shimadzu: Analytical Technologies for COVID-19 Challenges: Drug Repurposing | Vaccine Research | PPE & Material Testing | Environmental Monitoring

Analytical Technologies for COVID-19 Challenges: Drug Repurposing | Vaccine Research | PPE & Material Testing | Environmental Monitoring

The current analytical technologies and solutions that Shimadzu is committed to provide.

Analytical Technologies for COVID-19 Challenges

Formation of nitrosamines, particularly NDMA, is prevalent in water treatment plants using chloramine as a disinfectant.
NDMA is classified as a B2 carcinogen based on the induction of tumors at multiple sites in different mammal species exposed to NDMA by various routes. EPA 521 has been provided as the validated extraction and analytical procedure for monitoring of nitrosamines in drinking water. However, this method was developed using large volume injections (20 µL) and ion trap spectrometers in MS/MS chemical ionization (CI) mode (with methanol or acetonitrile). To avoid the complexity of large volume injections and CI, we present the alternative gas chromatography triple quadrupole electron ionisation method. Additionally, calibrants were prepared via an auto-sampler, from 1000 µg/ml commercially available standards.
Learning Objectives:
Introduction and background on nitrosamines analysis in water samples Development of GC-MS/MS electron ionisation method Learn about the method application on field samples
<blockquote>
Presenter: Crystal Yeong (Ph.D.) (Senior Field Application Chemist, Shimadzu (Asia Pacific) Pte Ltd)
</blockquote>
<blockquote>
Crystal Yeong is a senior field application chemist for GC and GCMS at Shimadzu (Asia Pacific) Pte Ltd in Singapore. She has experience in forensic applications, nitrosamines impurities detection and PAH analyses in edible oils. Prior to joining Shimadzu, she was a lab analyst with the Ministry of Home Affairs, Singapore. Crystal holds a PhD in Inorganic Chemistry and B.Sc. in Chemistry &amp; Biological Chemistry from Nanyang Technological University.
</blockquote>

Shimadzu: Monitoring Nitrosamines in Water using GC-MS/MS via Electron Ionisation and Quantitation Comparison with GC-MS via Chemical Ionisation

Monitoring Nitrosamines in Water using GC-MS/MS via Electron Ionisation and Quantitation Comparison with GC-MS via Chemical Ionisation

Alternative gas chromatography triple quadrupole electron ionisation method.

Monitoring Nitrosamines in Water using GC-MS/MS

Forensic chemists face the challenge of identifying new psychoactive substances (NPS), whereby the general structures of controlled drugs are modified to evade legislative banning.
Hence, a plethora of synthetic cathinones and cannabinoids has been available to the public, causing a global social problem. It is therefore crucial that analytical methods are developed for identifying and differentiating new analogues of synthetic drug substances, to prevent potential trading and abuse. Additionally, drug legislation is made more challenging with the use of synthetic cannabinoid containing products, typically marketed as “herbal mixtures”, which consists of analogues of synthetic cannabinoids. In this study, simultaneous multi-reaction monitoring (MRM) and product ion scan (PIS) acquisition methods have been developed for detection and differentiation of isomeric synthetic cannabinoids.
Data were acquired using a GC-MS/MS system (GCMS-TQ8050, Shimadzu Corporation, Japan) in electron ionization mode. Two classes of synthetic cannabinoids were analysed. They are a mixture of JWH-018 (1-pentyl-3-(1-naphthoyl)indole) and its seven other structural isomers, and a mixture of four positional isomers of fluoro-PB-22 (Quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate).
<h5>Learning Objectives</h5>
<ul>
<li>Background of New Psychoactive Substance (NPS) and the types of synthetic cannabinoids
</li>
<li>Method development for the differentiation of eight structural isomers of JWH-018
</li>
<li>Method development for the differentiation of four positional isomers of Fluoro-PB-22
</li>
<li>Method applications on NPS-fortified samples
</li>
</ul>
<blockquote>
Presenter: Crystal Yeong (Ph.D.) (Senior Field Application Chemist, Shimadzu (Asia Pacific) Pte Ltd)
</blockquote>
<blockquote>
Crystal Yeong is a senior field application chemist for GC and GCMS at Shimadzu (Asia Pacific) Pte Ltd in Singapore. She has experience in forensic applications, nitrosamines impurities detection and PAH analyses in edible oils. Prior to joining Shimadzu, she was a lab analyst with the Ministry of Home Affairs, Singapore. Crystal holds a PhD in Inorganic Chemistry and B.Sc. in Chemistry &amp; Biological Chemistry from Nanyang Technological University.
</blockquote>

Shimadzu: Using MRM/Product Ion Scan Mode in GC-MS/MS to Perform Detection and Differentiation of Synthetic Cannabinoids

Using MRM/Product Ion Scan Mode in GC-MS/MS to Perform Detection and Differentiation of Synthetic Cannabinoids

Simultaneous multi-reaction monitoring and product ion scan acquisition methods have been developed for detection and differentiation of isomeric cannabinoids.

Using MRM/Product Ion Scan Mode in GC-MS/MS

This webinar provides a glimpse of the cutting-edge technology Shimadzu GCMSMS offers in the field of food safety.
Agricultural industry faces a huge challenge of producing increasing quantities of food. While meeting such expanding global food demand, the safety and sustainability of food supply is of utmost importance. With the use of chemicals, significant reduction in crop losses and thus increased yield has been achieved. However, the resulting pesticide residues is of growing concern with its potential health risks. The exponential growth of chemical hazards and their regulations have brought several challenges to the food safety industry. It is particularly challenging for laboratories to accurately analyse large amounts of samples and detect the non-compliant ones. 
Understanding current laboratory requirements, GCMS-NX series along with its robust and sensitive hardware provides simplified user-friendly software for handling large multi-component data. Along with the unmatched hardware performance, Shimadzu also offers customizable databases and method packages as a total solution. 
<blockquote>
Presenter: Durvesh Sawant (Senior Application Chemist, Shimadzu Analytical India Pvt. Ltd.)
</blockquote>
<blockquote>
Mr. Durvesh Sawant has completed his Masters in Bioanalytical Sciences, having overall more than 8 years of experience in Analytical Chemistry.
</blockquote>
<blockquote>
His expertise lies in analysis of residual contaminants in various food matrices and pharmaceutical products with cutting edge technology like GCMS/GCMSMS. He has hands on experience on critical sample preparation techniques. He has participated as a speaker in various Food safety Seminars across India and as a trainer in FSSAIs’ trainers’ training program conducted in National Research Centre for Grapes, Pune.
</blockquote>

Shimadzu: Shimadzu GCMSMS Solutions for Food Safety

Shimadzu GCMSMS Solutions for Food Safety

Glimpse of the cutting-edge technology Shimadzu GCMSMS offers in the field of food safety.