<div><div id=""><div><div><div><div><strong>Extension for Detailed Hydrocarbon Analysis. It allows the determination of individual components in spark ignition engine fuels.</strong></div></div></div></div></div></div><div><div id=""><div><div><div><div><div><p>DHA Extension brings you the ability to calculate the properties of the samples directly in the chromatography software with the complete workflow of <strong>data acquisition</strong>, <strong>peak calibration</strong>, <strong>DHA calculations</strong> based on supported norms and reporting. These methods are often referred to as <strong>PONA</strong>, <strong>PIONA</strong>, <strong>O-PON</strong>A, etc.</p><p>Calculations in the <strong>DHA Extension</strong> currently support the <strong>ASTM D-6730</strong> standard and methods developed by <strong>Dani Instruments SA</strong>.</p><figure class="image"><img style="aspect-ratio:1151/879;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_2_edfc9ba1f3.jpg" alt="DataApex: DataApex Clarity DHA (Detailed Hydrocarbon Analysis) Extension" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_2_edfc9ba1f3.jpg 204w," sizes="100vw" width="1151" height="879"></figure></div></div></div></div></div></div></div><p>You can create an <strong>additional custom method</strong> based on your own laboratory condititions or we can implement a standard method as part of the DHA extension at your request.</p><p>If you request to implement another norm in the DHA Extension, please contact us at <a href="mailto:support@dataapex.com">support@dataapex.com</a>.</p><p>The DHA Extension is optional and it can only be used together with <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/999"><strong>Clarity</strong></a>.</p><p>Note that for more complex DHA calculations, Clarity DHA Extension should be complemented by specialized software (e.g. Dragon II DHA© - see the <a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/downloads/26175/view">D151 datasheet</a> for more details).</p><p><strong>The DHA Extension is an optional fully integrated addition to </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/999"><strong>Clarity software</strong></a><strong>. It can be ordered as part of a new installation or as an extension to an existing one. There are two variants to this extension:</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_bc1e53cf67.jpg" alt="DataApex: DataApex Clarity DHA (Detailed Hydrocarbon Analysis) Extension" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_bc1e53cf67.jpg 211w," sizes="100vw" width="1223" height="906"></p><h5><strong>p/n A33</strong></h5><ul><li>includes general ASTM-D6730 standard method and the possibility to create custom method.</li></ul><h5><strong>p/n A331</strong></h5><ul><li>includes additional methods developed by DANI Instruments S.p.A</li></ul><h3 data-start="49" data-end="78"><strong data-start="53" data-end="76">Norms specification</strong></h3><h4 data-start="80" data-end="102"><strong data-start="85" data-end="100">ASTM D-6730</strong></h4><ul data-start="103" data-end="302"><li data-start="103" data-end="127">Included in p/n A33.</li><li data-start="128" data-end="302">Standard Test Method for Determination of Individual Components in Spark Ignition Engine Fuels by 100-Metre Capillary (with Precolumn) High-Resolution Gas Chromatography.</li></ul><h4 data-start="304" data-end="328"><strong data-start="309" data-end="326">Custom Method</strong></h4><ul data-start="329" data-end="441"><li data-start="329" data-end="353">Included in p/n A33.</li><li data-start="354" data-end="441">Allows you to create a custom method which meets the conditions in your laboratory.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_3_f5e659a432.jpg" alt="DataApex: DataApex Clarity DHA (Detailed Hydrocarbon Analysis) Extension" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_3_f5e659a432.jpg 245w," sizes="100vw" width="1233" height="756"></p><h4><strong data-start="452" data-end="475">ASTM D-6730 by DANI</strong></h4><ul data-start="478" data-end="578"><li data-start="478" data-end="535">Method by Dani Instruments SA with cryogenic cooling.</li><li data-start="536" data-end="578">Available only at Dani Instruments SA.</li></ul><h4 data-start="580" data-end="619"><strong data-start="585" data-end="617">ASTM D 2421-02 and D 2598-02</strong></h4><ul data-start="620" data-end="720"><li data-start="620" data-end="677">Method by Dani Instruments SA with cryogenic cooling.</li><li data-start="678" data-end="720">Available only at Dani Instruments SA.</li></ul><h4><strong data-start="731" data-end="758">Extension specification</strong></h4><ul data-start="761" data-end="911"><li data-start="761" data-end="782"><strong data-start="763" data-end="776">Part No.:</strong> A33</li><li data-start="783" data-end="911"><strong data-start="785" data-end="806">Related products:</strong><ul data-start="811" data-end="911"><li data-start="811" data-end="832"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/999">Clarity</a> (p/n C50)</li><li data-start="835" data-end="864"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1000">Clarity Offline</a> (p/n C59)</li><li data-start="867" data-end="911">GC or AS Control module (p/n A23 or A26)</li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_2_d15379bcdf.jpg" alt="DataApex: DataApex Clarity DHA - Detailed Hydrocarbon Analysis Extension" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_2_d15379bcdf.jpg 245w," sizes="100vw" width="1995" height="1182"></p>

DataApex Clarity DHA (Detailed Hydrocarbon Analysis) Extension

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 24th February 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies, Knauer&nbsp; </strong>and <strong>Shimadzu</strong>!</p><h4><strong>1. Agilent Technologies: Analysis of 65 Volatile Organic Compounds in Ambient Air by Canister Sampling Using an Agilent </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=8890%2F5977"><strong>8890/5977</strong></a><strong> GC/MSD</strong></h4><h5><strong>A method using both scan and SIM mode that fully meets the requirements in the HJ 759-2023 standard</strong></h5><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_voc_air_gc_msd_5994_7723en_agilent_4b88e40417.pdf"><strong>Full PDF for download</strong></a></li></ul><p>This application note introduces the use of a canister for gas sampling. Samples were introduced into an Agilent 8890 gas chromatograph (GC) with an Agilent 5977 single quadrupole mass selective detector (MSD) and the Markes Multi-Gas thermal desorption (TD), to analyze volatile organic compounds (VOCs) in the atmosphere or in semiconductor cleanrooms. The results of linearity, reproducibility, and detection limit fully met the requirements of the China method HJ759-2023. This method is widely used as a reference both in environmental laboratories and semiconductor cleanrooms. The linear correlation coefficient for all 65 compounds was greater than 0.991, with 86% of compounds having a value greater than 0.999. The results of reproducibility in scan mode varied between 0.3 to 6.8%, while results in SIM mode varied between 1.1 to 6.7%. The sampling volume was 300 mL, which resulted in detection limits of 0.013 to 0.113 nmol/mol for scan mode and 0.002 to 0.013 nmol/mol for SIM mode.&nbsp;</p><h4><strong>Experimental</strong></h4><p>This study was performed on an 8890 GC coupled to a 5977 single quadrupole GC/MSD with an electron ionization (EI) source. A Markes Multi-Gas thermal desorption sample introduction and preconcentration system was used and included three modules:</p><ul><li>CIA Advantage-xr (CIA): canister autosampler</li><li>Kori-xr: water removal module</li><li>Unity-xr: thermal desorption instrument</li></ul><p>First, three internal standards (ISTDs) were introduced into the Unity trap by CIA. Then, the sample was passed through a heated transfer line through the CIA Advantage<br>into the Kori for water removal. Finally, the sample flowed into the focusing cold trap of the Unity for preconcentration. Eventually, the Unity trap was desorbed at high temperature, and the 65 VOCs and three ISTDs all entered the GC/MSD for analysis. Figure 1 shows the flow path of the combined system.&nbsp;</p><h4><strong>Conclusion</strong></h4><p>An Agilent 8890/5977 GC/MSD system, equipped with a Multi-Gas CIA Advantage-xr TD provides a robust analytical procedure for the analysis of 65 VOCs in ambient air. This system offers a highly efficient and highly sensitive solution for the simultaneous analysis of multiple VOCs in both atmospheric quality monitoring laboratories and semiconductor cleanrooms. Based on different application requirements, users can choose to collect data in scan or SIM mode, demonstrating the flexibility of Agilent instruments. Excellent analytical performance has been achieved based on this system both in scan and SIM mode, which fully meets the requirements detailed in method HJ 759-2023.</p><h4><strong>2. Knauer: GPC vs. SPE and subsequent determination of polycyclic aromatic hydrocarbons using GC/MS</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/VEV_0081_Comparison_of_GPC_and_SPE_purification_methods_of_sludge_samples_FINAL_web_376100390f.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants generated primarily during the incomplete combustion of organic materials. The removal of PAHs from the atmosphere by dry and wet deposition processes are strongly influenced by their gas/particle partitioning. Atmospheric deposition is a major source for PAHs in soil [1] which can be determined by various extraction and purification processes, subsequently detected by a GC/MS using the reference method UNI EN 15527. Our main purpose is to demonstrate that the purification of environmental matrix with high organic component using the gel permeation chromatography purification (AZURA GPC Cleanup, FS conditioned resins CHEX/DCM), compared to a SPE purification, allows are well-defined separation time of the analytes and it can provide narrow bands without their physical chemical interaction with the column, resulting in less chance of loss of analytes [2]. This differs from other separation techniques which depend upon chemical or physical interactions to separate analytes [3].</p><h4><strong>Conclusion</strong></h4><p>The GPC cleanup procedure of mud sludge samples prior analysis of PAHs with GC/MS technique is a good alternative to SPE purification steps. Advantages like better S/N ratios and third mass identification are obvious. The automatization of the GPC Cleanup using AZURA GPC Cleanup system yields high efficiency of the application.</p><h4><strong>3. Shimadzu: Material Analysis of Microplastics in River Water - FTIR and Pyrolysis-GC-MS Analysis</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00806_en_c2c7bba8be.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>Automated pretreatment of microplastics (MPs) reduces workload and enables highly reproducible pretreatment.</li><li>Material analysis of MPs processed by the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=MAP-100"><strong>MAP-100</strong></a> device can be easily performed by <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=FTIR-ATR"><strong>FTIR+ATR.</strong></a></li><li>Highly reproducible GC-MS analysis of MPs is possible by homogeneously pulverizing samples with Cryogenic Mill (IQ MILL-2070).</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=EGA%2FPY-3030D"><strong>Pyrolysis</strong></a>-<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=GCMS-QP2020+NX"><strong>GC-MS</strong></a> can measure the weight of multiple types of plastics even when they are mixed.</li></ul><p>Microplastics (MPs) are microscopic plastic particles measuring a few µm to 5 mm in size. They are feared to have an impact on ocean pollution and ecosystems. Against this backdrop, surveys and studies on MPs in surface waters such as oceans, rivers, lakes and marshes are being conducted worldwide. Fourier Transform Infrared Spectrophotometer (FTIR) is often used for material analysis of MPs. ASTM recently published the D8401-24 standard test method for the qualitative and quantitative determination of MPs in water that uses a pyrolysis gas chromatograph mass spectrometer (Py-GC-MS). In this application news, a sample taken from a river was pretreated and analyzed for MPs using FTIR and Py-GC-MS.</p><h4><strong>Conclusion</strong></h4><p>Samples collected from river water were automatically pretreated using MAP-100, and the MPs materials were then analyzed by FTIR and Py-GC-MS. PP, PE and EVA were detected in both instruments, indicating that PP and PE are the main components (Fig. 8). Using an FTIR, individual qualitative results can be obtained easily, and the number ratios and densities can be calculated. Py-GC-MS also provides a more accurate massto material ratio (%). The system supports screening methods that take advantage of the features of each instrument, from preparation to analysis of MPs.</p>

News from LabRulezGCMS Library - Week 9, 2025

<p><strong>In today's data-driven world, analytical software plays a pivotal role in transforming raw data into actionable insights. These tools are the backbone of decision-making processes in industries ranging from finance and healthcare to marketing and logistics. As the volume and complexity of data continue to grow, the need for more sophisticated and efficient analytical tools becomes paramount. This necessitates regular upgrades to analytical software, ensuring that businesses can keep pace with technological advancements and evolving market demands.&nbsp;</strong></p><h3><strong>The Necessity of Analytical Software Upgrades</strong>&nbsp;</h3><p>Due to the complexity of the decision to upgrade software it can be always dismissed, however it should be reviewed annually to see if the benefits outweigh the disadvantages.</p><p><strong>Enhanced Performance and Speed:</strong> As datasets become larger and more complex, the processing power of older software versions often falls short. Upgrades typically come with improved algorithms and more efficient processing capabilities, allowing for quicker and more data analysis with faster generation of insights.</p><p><strong>Advanced Features and Capabilities: </strong>New versions of analytical software often include cutting-edge features such as pattern recognition visualisation, real-time data processing, and trending analytics. These capabilities enable laboratories to increase instrument uptime and troubleshoot instrument and analytical issues more swiftly.&nbsp;</p><p><strong>Improved User Experience:</strong> Upgrades frequently focus on user interface enhancements, making the software more intuitive and easier to navigate. This reduces the learning curve for new users and enhances productivity for experienced users.</p><p><strong>Compliance Enhancements:</strong> With the increasing prevalence of cyber threats, ensuring data security is more critical than ever. Upgraded software versions often come with advanced compliance with the latest industry standards, providing digital traceability of methods and results.</p><p><strong>Integration with Modern Technologies:</strong> Analytical software must integrate seamlessly with other tools and platforms used by businesses. Upgrades ensure compatibility with the latest technologies, such as Microsoft Office/Adobe products and LIMS data platforms, facilitating a more cohesive and efficient data integration.</p><figure class="image"><img style="aspect-ratio:997/661;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Chrom_Solutions_Software_Upgrades_Quick_Reference_Guide_a3c46947cc.jpg" alt="ChromSolutions: Software Upgrades Quick Reference Guide." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Chrom_Solutions_Software_Upgrades_Quick_Reference_Guide_a3c46947cc.jpg 235w," sizes="100vw" width="997" height="661"></figure><h3><strong>Challenges in Upgrading Analytical Software</strong></h3><p>Despite the clear benefits, upgrading analytical software can present several challenges:</p><p><strong>Costs: </strong>New software may not be back compatible with your existing PC, operating system software, instrument firmware and drivers. Even the initial investment required for new software licenses, training, and implementation can be substantial. Businesses must carefully evalu- ate the cost-benefit ratio to ensure a positive return on investment.</p><p><strong>Implementation Time:</strong> Upgrading software can be a time-consuming process, potentially leading to temporary disruptions in operations. Effective planning and project management are crucial to minimize downtime and ensure a smooth transition.&nbsp;</p><p><strong>Training: </strong>New software versions often come with new features and interfaces, requiring staff to undergo training. This can temporarily reduce productivity as employees adapt to the new system.&nbsp;</p><p><strong>Data Migration: </strong>Ensuring a seamless transfer of methods and data from the old system to the new one can be complex. Businesses must ensure that data integrity is maintained and that no critical information is lost during the migration process.</p><h3><strong>The Impact of Upgraded Analytical Software</strong></h3><p><strong>Empowered Decision-Making:</strong> With access to more sophisticated analytical tools, businesses can make more informed and accurate decisions. Enhanced analytical capabilities allow for deeper insights into market trends, customer behavior, and operational efficiencies.</p><p><strong>Competitive Advantage:</strong> Companies that leverage the latest analytical tools can gain a significant competitive edge. By quickly adapting to market changes and identifying new opportunities, businesses can stay ahead of their competitors and capture a larger market share.&nbsp;</p><p><strong>Operational Efficiency: </strong>Upgraded software often includes automation features that streamline repetitive tasks, reducing the burden on human resources. This allows employees to focus on higher- value activities, improving overall operational efficiency.&nbsp;</p><p><strong>Cost Savings:</strong> While there is an initial investment associated with upgrading software, the long-term cost savings can be substantial. Improved efficiency, reduced downtime, and the ability to make better business decisions can lead to significant financial benefits.&nbsp;</p><p><strong>Enhanced Customer Experience: </strong>Advanced analytical tools enable businesses to gain a deeper understanding of their customers' needs and preferences. This allows for more personalized and targeted marketing efforts, enhancing the overall customer experience and driving loyalty.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Chrom_Solutions_Software_Upgrades_Quick_Reference_Guide_2_852a31cf7b.jpg" alt="ChromSolutions: Software Upgrades Quick Reference Guide." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Chrom_Solutions_Software_Upgrades_Quick_Reference_Guide_2_852a31cf7b.jpg 245w," sizes="100vw" width="1724" height="653"></p><h3><strong>Conclusion</strong></h3><p>The rapid evolution of technology necessitates regular upgrades to analytical software, providing businesses with the tools they need to stay competitive in a data-driven world. While there are challenges associated with the upgrade process, the benefits far outweigh the drawbacks. Enhanced performance, advanced features, improved user experience, and robust security measures are just a few of the advantages that upgraded analytical software brings to the table. By investing in the latest analytical tools, businesses can make more informed decisions, improve operational efficiency, and ultimately achieve greater success in their respective markets. ChromSolutions can help customers navigate all these considerations to provide a cost effective and successful outcome.</p><h3><strong>ChromSolutions Ltd</strong></h3><p>What we offer at ChromSolutions is our wealth of experience in analytical instrument sales and support (over 120 years distributed through the members of our company). We can help you with a cost effective software upgrades with the benefit of our partners.</p>

Chromatography software Upgrades Quick Reference Guide

<p>Every chromatographer knows that selecting the right fitting components is essential for the smooth operation of an HPLC system. One of the critical elements is the <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/suppliers/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky"><strong>NUT</strong></a> – the part responsible for <strong>ensuring the ferrule creates a secure, leak-free connection</strong>.</p><h4><strong>What should you consider when choosing a nut?</strong></h4><h5><strong>#1 Thread Types Matter</strong></h5><p><strong>External or internal?</strong> Each has its specific applications. Most nuts have “external threads“,however Some nuts have “internal threads”.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Picture_1_Different_between_Externally_Threaded_and_Internally_Threaded_Nuts_eec6ae8c86.jpg" alt="Watrex: Picture 1: Different between ExternallyThreaded and Internally-Threaded Nuts." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Picture_1_Different_between_Externally_Threaded_and_Internally_Threaded_Nuts_eec6ae8c86.jpg 245w," sizes="100vw" width="1667" height="833"></p><h5><strong>#2 Head Geometry</strong></h5><p><strong>Knurled, hexagonal, square, winged? </strong>The right design makes tightening easier. Nuts come in various head designs, each suited to specific needs:</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Picture_2_Variants_of_head_geometry_20a9a263d9.jpg" alt="Watrex: Picture 2: Variants of head geometry." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Picture_2_Variants_of_head_geometry_20a9a263d9.jpg 245w," sizes="100vw" width="1667" height="833"></p><h5><strong>#3 Size Matters!</strong></h5><p><strong>Nut Length:</strong> Long nuts work well in angled or tight spaces, while short nuts suit compact systems. Thru-Hole Diameter: Matches the tubing’s outer diameter.</p><h5><strong>#4 Materials</strong></h5><p><strong>Stainless steel or polymer?</strong> Each material has unique advantages for diferent applications.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Picture_3_Materials_in_which_nuts_can_be_found_8541810917.jpg" alt="Watrex: Picture 3: Materials in which nuts can be found." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Picture_3_Materials_in_which_nuts_can_be_found_8541810917.jpg 245w," sizes="100vw" width="1667" height="833"></p><h3><strong>Why does it matter?</strong></h3><p>Choosing the right nut ensures precision, reliability, and ease of use for your HPLC system.</p><p><strong>Choose from our suppliers: </strong><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/suppliers/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky"><strong>Vici, IDEX and Optimize Technologies</strong></a><strong>.</strong></p><p><strong>Need Help Choosing the Right Nut?</strong> Contact us at: watrex@watrex.com</p>

4 things you should know about the chromatography nuts!

<p><strong>Polycyclic aromatic hydrocarbons (PAHs) are a prominent class of organic compounds that have raised significant concerns due to their presence in various environmental and food matrices. These compounds are composed of multiple aromatic rings and are primarily formed during the incomplete combustion of organic matter. Sources of PAHs range from natural processes like forest fires to human activities such as vehicle emissions, tobacco combustion, and food preparation techniques like grilling or smoking.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Unveiling_the_Advanced_Workflow_for_PAH_Analysis_in_Smoke_Flavored_Foods_427c35f34b.jpg" alt="Thermo Fisher Scientific: Unveiling the Advanced Workflow for PAH Analysis in Smoke Flavored Foods." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Unveiling_the_Advanced_Workflow_for_PAH_Analysis_in_Smoke_Flavored_Foods_427c35f34b.jpg 234w," sizes="100vw" width="1024" height="683"></p><p>In the food industry, PAHs are particularly relevant in the context of smoke-flavored products. While smoke flavorings enhance the sensory properties of foods, they also pose potential risks due to the formation of PAHs during the smoking process. As such, stringent analytical methods are essential for detecting and quantifying PAHs to ensure consumer safety. In this blog, we explore a comprehensive <strong>GC-MS/MS</strong> workflow specifically designed for <strong>PAH analysis in smoke-flavored foods</strong>, with a focus on innovation in <strong>sample preparation, instrumental sensitivity,</strong> and <strong>regulatory compliance</strong>.</p><h3 id="h-understanding-smoke-flavors-and-pahs"><strong>Understanding smoke flavors and PAHs</strong></h3><p>Smoke flavorings are derived from the controlled combustion of specific wood types, which are subsequently condensed, fractionated, and purified. These flavorings are used in foods such as fish, meat, sauces, and even snacks to replicate traditional smoking processes. <strong>The primary flavoring components</strong> include <strong>phenols </strong>and <strong>carbonyl compounds</strong> (aldehydes and ketones).</p><p>However,<strong> </strong>PAHs can also be introduced during this process. Examples include <strong>naphthalene</strong> (two aromatic rings), <strong>anthracene</strong>, and <strong>phenanthrene</strong> (three aromatic rings), which are considered<strong> lower molecular weight PAHs</strong>, alongside <strong>heavier compounds </strong>such as <strong>benzo(a)pyrene</strong> and <strong>coronene</strong>. Regulatory frameworks in the European Union (e.g., Regulation (EC) No. 2065/2003) ensure that only authorized smoke flavoring products are used, with maximum allowable levels for PAHs.</p><h3 id="h-the-challenges-of-pah-analysis-in-food-matrices"><strong>The challenges of PAH analysis in food matrices</strong></h3><p>Analyzing PAHs in food matrices, particularly those with high-fat content, presents unique challenges. These include:</p><ol><li><strong>Complexity of matrices</strong>: Foods like smoked trout and tofu contain fats and proteins that can interfere with analytical detection.</li><li><strong>Stringent detection requirements</strong>: Regulatory limits demand detection of PAHs at extremely low concentrations (picogram to femtogram levels).</li><li><strong>Sample throughput</strong>: Laboratories need workflows that are both sensitive and efficient to handle routine analysis of multiple samples daily.</li></ol><h3 id="h-a-comprehensive-workflow-for-pah-analysis"><strong>A comprehensive workflow for PAH analysis</strong></h3><h5><strong>1. Sample preparation: The foundation of accurate results</strong></h5><p>Sample preparation is a critical step in PAH analysis, especially for fat-containing matrices. A robust and systematic approach minimizes matrix interferences and enhances analyte recovery. The workflow includes:</p><ul><li><strong>Homogenization</strong>: A 5-gram sample is weighed and homogenized in a glass tube. Internal standards are added, followed by equilibration for 10 minutes.</li><li><strong>Liquid extraction</strong>: Samples are extracted using hexane in an ultrasonic bath. This process is repeated five times to ensure thorough extraction.</li><li><strong>Evaporation and cleanup</strong>: Extracts are evaporated to 1 mL and subjected to Solid Phase Extraction (SPE). Two SPE steps are employed:<ul><li><strong>Primary SPE (HyperSep Florisil)</strong>: Removes major interferences.</li><li><strong>Secondary SPE (HyperSep Phenyl)</strong>: Further purifies the sample for precise GC-MS/MS analysis.</li></ul></li></ul><h5><strong>2. Advanced instrumentation: The role of GC-MS/MS</strong></h5><p>Instrumentation plays a pivotal role in achieving the sensitivity required for PAH detection. The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/485"><strong>Thermo Scientific TSQ 9610 GC-MS/MS</strong></a> system incorporates cutting-edge technologies to address the demands of PAH analysis:</p><ul><li><strong>Advanced electron ionization (AEI)</strong>: This ion source provides superior sensitivity through highly efficient ionization and a tightly focused ion beam. This ensures robustness even with challenging matrices.</li><li><strong>NeverVent technology</strong>: Unique design features allow vent-free column and ion source exchanges, maximizing instrument uptime.</li><li><strong>Dual filament design</strong>: Extends the operational lifespan and reduces maintenance frequency.</li></ul><h5><strong>3. Importance of glass quality in analytical accuracy</strong></h5><p>The quality of glass materials used in vials and liners significantly impacts analytical outcomes. <strong>Thermo Fisher Scientific’s LinerGold technology</strong> addresses the challenges posed by active glass surfaces that can adsorb PAHs, leading to signal loss or contamination. By providing highly inert glass materials, the workflow ensures consistent and accurate results.</p><h3 id="h-results-and-key-findings"><strong>Results and key findings</strong></h3><p>The GC-MS/MS workflow for PAH analysis has been rigorously tested on various food matrices, demonstrating its robustness and reliability. Key findings include:</p><ul><li><strong>Ultra-low detection limits</strong>: The system achieves femtogram-level detection, with examples such as chrysene (150 fg in smoked trout) and coronene (320 fg in smoked trout).</li><li><strong>Precision and reproducibility</strong>: Calibration curves for compounds like pyrene and benzo(k)fluoranthene exhibit excellent linearity, ensuring reliable quantification.</li><li><strong>Wide applicability</strong>: The workflow performs well across diverse matrices, from smoked trout to tofu, maintaining compliance with regulatory limits.</li></ul><h3 id="h-regulatory-compliance-and-consumer-safety"><strong>Regulatory compliance and consumer safety</strong></h3><p>Ensuring compliance with EU regulations is a cornerstone of PAH analysis in smoke-flavored foods. The presented workflow not only meets these standards but also provides a scalable solution for routine laboratories. By integrating advanced sample preparation, state-of-the-art instrumentation, and high-quality consumables, laboratories can confidently deliver accurate and reliable results.</p><h3 id="h-conclusions-and-future-perspectives"><strong>Conclusions and future perspectives</strong></h3><p>The detection and quantification of PAHs in smoke-flavored foods require a synergistic approach that combines meticulous sample preparation with innovative GC-MS/MS technology. The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/485"><strong>Thermo Scientific TSQ 9610</strong></a> system, with its AEI source and <strong>NeverVent technology</strong>, sets a new benchmark in analytical sensitivity and robustness.</p><p>This workflow underscores the importance of quality at every step—from sample preparation to vial selection—to achieve the necessary detection limits and regulatory compliance. As analytical demands evolve, these advancements pave the way for safer food production and enhanced consumer protection.</p><blockquote><h5><strong>Additional information:</strong></h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/485">TSQ 9610 Triple Quadrupole GC-MS</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/products-and-services/promotions/industrial/chromatography-columns-consumables-available-online.html">Chromatography Columns and Consumables Now Available Online</a></li></ul></blockquote><div><div><blockquote><h5><strong>Join our free webinars:</strong></h5><p>20.3.2025 English, 11 am CET, 1 hour<br><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4756">Advanced workflow for PAH analysis of smoke flavored foods</a></p><p>25.3.2025 German, 11 am CET, 1 hour<br><a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/4835418/2EEB616DFE5F57C6587BA5984198FE55">Innovativer Workflow für die PAK-Analyse in Lebensmitteln mit Raucharoma</a><br><br>After the actual dates they are available on demand using the same links.</p></blockquote></div></div><blockquote><h5><strong>Visit us on </strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong>LinkedIn:</strong></a><strong> </strong>#SmokeFlavors #Pah #GCMS #Consumables</h5></blockquote><section><blockquote><h4><strong>Petra Gerhards</strong></h4><p>Petra Gerhards, Dipl-Ing, is Regional Marketing Manager of GC and GC-MS for EMEA at Thermo Fisher Scientific. She has more than 29 years of experience in the fields of GC-MS, SPE and LC-MS. Since joining the regional team she has contributed to workflow solutions combining vials and closures with SPE solutions, GC-MS and LC-MS. She works with KOL's on data for regional specific marketing campaigns, organizes in-house seminars and works on customer specific solutions. Her main expertise is in the field of doping and drugs-of-abuse analysis.</p></blockquote></section>

Unveiling the Advanced Workflow for PAH Analysis in Smoke Flavored Foods

<p><strong>For analytical scientists working with chromatography and mass spectrometry, protecting sensitive information is crucial. Advances in instrument and software technology, combined with increased demands for in-depth analytics, has significantly increased the volume of valuable data that must be safeguarded from unauthorized access and potential breaches. One effective strategy to enhance security is to centralize data management, storing data away from the initial point of acquisition. Let us explore how this approach can significantly strengthen security for chromatography and mass spectrometry users and facilitate adherence to regulatory compliance measures surrounding electronic records.&nbsp;</strong></p><h4><strong>Understanding the analytical science landscape&nbsp;</strong></h4><p>Chromatography and mass spectrometry are critical techniques in many fields including pharmaceuticals, environmental analysis and biochemistry. The data generated from these methods includes intricate details about potentially proprietary chemical compositions and biological information. Protecting this data is crucial to maintaining the integrity of scientific research and the competitive edge of organizations.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Enhanced_Security_Through_Centralized_Data_Management_A_guide_for_Chromatography_and_Mass_Spectrometry_Users_95f6d464f1.webp" alt="Thermo Fisher Scientific: Enhanced Security Through Centralized Data Management - A guide for Chromatography and Mass Spectrometry Users" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Enhanced_Security_Through_Centralized_Data_Management_A_guide_for_Chromatography_and_Mass_Spectrometry_Users_95f6d464f1.webp 245w," sizes="100vw" width="1200" height="600"></p><h4><strong>The data security challenge&nbsp;</strong></h4><p>Data acquisition, processing, storage and reporting has traditionally been conducted on isolated, static hardware-bound workstations. This approach presents significant security risks:</p><ul><li><strong>Single point of failure: </strong>An isolated system with poor backup strategies can be vulnerable to catastrophic data loss via accidental damage or environmental changes. Any compromise can lead to data corruption, loss or unauthorized alterations.&nbsp;</li><li><strong>Accessibility and convenience: </strong>Storing and processing data in a noisy lab environment can be inconvenient and impractical. Technical staff are often competing for access to instruments using the same workstation that others need for processing. This often leads to users manually transferring data outside of a controlled system for processing elsewhere. &nbsp;</li></ul><h4><strong>The case for centralized data management&nbsp;</strong></h4><p>Centralizing data management involves storing data in a central server location, away from the initial point of data acquisition. Here is how this approach can enhance security and usability for chromatography and mass spectrometry users:</p><ul><li><strong>Reduced risk:</strong> A centralized system that has redundancies and backups in place can alleviate the risks associated with a single point of failure. Attackers trying to gain access will also have to deal with robust security measures not typically seen with isolated workstations&nbsp;</li><li><strong>Enhanced data integrity: </strong>With separate systems for acquisition and storage, the integrity of the data is better preserved. Any unauthorized changes on the acquisition workstation will not directly affect the stored data.&nbsp;</li><li><strong>Remote access and flexibility</strong>: Centralized data storage allows users to securely and conveniently access data from anywhere without manual transfer or copying the data.&nbsp;</li></ul><h4><strong>Data retention, integrity and auditing&nbsp;</strong></h4><p>Compliance with regulatory bodies such as the FDA (Food and Drug Administration) and &nbsp;EMA (European Medicines Agency) involves meeting stringent requirements for data integrity, security and retention. Centralized data management can help meet these requirements.</p><ul><li><strong>Data integrity and audit trails:</strong> Separating acquisition from storage lets organizations ensure long-term raw data integrity and traceability by controlling access and providing audit trails.&nbsp;</li><li><strong>Secure data retention: </strong>Regulations often mandate that data submissions be stored securely for extended periods. Dedicated data storage solutions can be designed to meet these requirements of large data volumes in a cost-effective way, while also protecting data from unauthorized access, accidental damage and environmental threats. &nbsp;</li></ul><h4><strong>Practical implementation considerations for data security&nbsp;</strong></h4><p>Chromatography and mass spectrometry users looking to deploy a centralized data management system should consider some data security essentials:</p><ul><li><strong>Secure data transfer protocols:</strong> Use of encrypted channels for transferring data from the acquisition point to the central storage system.&nbsp;</li><li><strong>Robust authentication mechanisms:</strong> Multi-factor authentication (MFA) to control access to both acquisition and storage systems. Single sign-on (SSO) systems also offer convenience.&nbsp;</li><li><strong>Accessible audit trails and monitoring: </strong>Conducting regular security audits and continuous monitoring to detect and respond to potential threats promptly.&nbsp;</li><li><strong>Leverage cloud solutions:</strong> Consider using cloud-based solutions that offer built-in security features for both data acquisition and storage. Many cloud providers offer specialized services that can help segregate these functions securely.&nbsp;</li><li><strong>Compliance-focused data management: </strong>Ensure that the data management strategy aligns with regulatory requirements for data integrity, security and retention. This includes maintaining detailed records of data acquisition, storage, and processing activities.&nbsp;</li></ul><h4><strong>Conclusion&nbsp;</strong></h4><p>Centralizing data management by storing data away from the initial point of acquisition is a powerful strategy to enhance data security and facilitate regulatory compliance. Centralized data can be securely managed and shared remotely, allowing users to access data independently from the lab-bound workstations used for acquisition. Adopting secure data transfer protocols and robust authentication mechanisms can be made easier with modern cloud solutions. Scientists should feel empowered by these tools to protect their valuable data and maintain the integrity of their research. &nbsp;</p>

Enhanced Security Through Centralized Data Management: A guide for Chromatography and Mass Spectrometry Users

Petr Viewegh’s Microcosm and Macrocosm

<p><strong>In the week from February 24, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong data-start="64" data-end="165">1. Agilent Technologies: Detecting Microplastics in Cannabis: An Analysis Using LDIR Spectroscopy</strong></h5><ul data-start="167" data-end="214"><li data-start="167" data-end="201">Tu, 25.2.2025</li><li data-start="202" data-end="214"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/2772">Registration</a></li></ul><p data-start="216" data-end="280">Detecting Microplastics in Cannabis: An Analysis Using LDIR Spectroscopy.</p><h5><strong data-start="282" data-end="393">2. Separation Science/Biotage: Automated Sample Preparation for Multi-Residue Pesticide Analysis by LC-MS and GC-MS</strong></h5><ul data-start="395" data-end="443"><li data-start="395" data-end="430">We, 26.2.2025</li><li data-start="431" data-end="443"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4724">Registration</a></li></ul><p data-start="445" data-end="600">Learn how Biotage's automated preparation workflow can analyze the entire panel and produce results equivalent to manual preparation.</p><h5><strong data-start="602" data-end="718">3. LECO: Detailed Hydrocarbon Type Analysis of Aviation Fuels: Navigating the Challenges of Evolving Feed Stocks</strong></h5><ul data-start="720" data-end="768"><li data-start="720" data-end="755">We, 26.2.2025</li><li data-start="756" data-end="768"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4687">Registration</a></li></ul><p data-start="770" data-end="979">This webinar will review both historical and contemporary analytical methods used for HTA, with a focus on the evolving challenges associated with achieving accurate identification and quantification with GCxGC</p><h5><strong data-start="602" data-end="718">4. Wiley: Advances in Spectral Identification: SmartSpectra, Classifications, &amp; More!</strong></h5><ul data-start="720" data-end="768"><li data-start="720" data-end="755">We, 26.2.2025</li><li data-start="756" data-end="768"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4789">Registration</a></li></ul><p data-start="770" data-end="979">This webinar covers the latest advances in spectral analysis, including Wiley’s KnowItAll models, SmartSpectra, and functional group analysis tools.</p>

Webinars LabRulezGCMS Week 9/2025

Ionic liquid coating for stir bar sorptive extraction and its application for extraction and nontargeted screening analysis via TD-GC–Orbitrap-HRMS of pollutants in river water

<p><strong>In the week from March 3, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong data-start="64" data-end="165">1. Agilent Technologies: </strong><strong>Application of GC/MS for the Analysis of Poly-Aromatic Hydrocarbons (PAHs) and Pesticides in Drinking Water According to the Directive EU 2020/2184</strong></h5><div><div><ul><li><div>We, 5.3.2025 14:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4712">Registration</a></div></li></ul></div><p>The main analytical techniques for the analysis of PAHs and pesticides in GC/MS in drinking water, with particular attention to the Solid Phase Micro-Extraction (SPME) technique.</p></div>

Webinars LabRulezGCMS Week 10/2025

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Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

DataApex

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

Thermo Fisher Scientific

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

ChromSolutions Ltd was formed in 2004 and has a wealth of experience in sample preparation for chromatography and spectroscopy techniques. With over 120 years of collective experience ChromSolutions offer an independent source of advice and solutions for modern analytical challenges.

ChromSolutions

WATREX Prague is the distributor and producer of HPLC techniques in the Czech Republic and Slovakia. Main Chromatografic and Related Techniques Supported: LC, GPC, IC, IEC, Automated SPE, LC Columns and special column packings, LC method development, Software development, Laboratory Robots.

Unveiling the Advanced Workflow for PAH Analysis in Smoke Flavored Foods

Webinars LabRulezGCMS Week 10/2025

Ionic liquid coating for stir bar sorptive extraction and its application for extraction and nontargeted screening analysis via TD-GC–Orbitrap-HRMS of pollutants in river water

Chromatography software Upgrades Quick Reference Guide

4 things you should know about the chromatography nuts!

Petr Viewegh’s Microcosm and Macrocosm

Enhanced Security Through Centralized Data Management: A guide for Chromatography and Mass Spectrometry Users

News from LabRulezGCMS Library - Week 9, 2025

DataApex Clarity DHA (Detailed Hydrocarbon Analysis) Extension

Webinars LabRulezGCMS Week 9/2025

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Food contaminant testing: Powerful workflow solutions for evolving residue analysis - from pesticides to PFAS

Small Size, Big Impact – High-Performance Benchtop GC and GC/MS with the Agilent 8850 GC

Dynamic Blender