<p><strong>In Ferbruary 2021, so far the following webinars await you in the field of GC and GCMS. More <a href="https://gcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>600 GC and LC webinars</strong>.</p>
<h5><strong>1. Agilent Technologies: Accelerated PAH screening using Intuvo GC with MS Detection</strong></h5>
<p>In this webinar, by applying direct heating technology of the Intuvo GC a screening method has been developed, offering an extraordinary injection to injection time of 9 minutes.</p>
<h5><strong>2. C&amp;EN/Agilent Technologies: Agilent OpenLab Remote Access Solutions to increase productivity</strong></h5>
<p>This webinar introduces using &quot;Thin Client&quot; technology which enables all Masshunter, ChemStation or OpenLab CDS to be accessed outside the lab, whether this is at from nearby desks, across sites, or from home. </p>
<h5><strong>3. Agilent Technologies: The Intuvo Trifecta: One Instrument, Three Analyses- Pesticides, Residual Solvents, and Terpenes</strong></h5>
<p>This presentation will examine the evolution of Agilent’s cannabis testing workflows culminating in the Intuvo Trifecta methodologies that have shifted the paradigm of cannabis testing in the gas-phase.</p>
<h5><strong>4. C&amp;EN/Eurofins: A Scientific Journey of a Niche API Achieving Breakthrough Status by the FDA for a Lifesaving Drug for Infants</strong></h5>
<p>A case study illustrating how to overcome technical challenges of an orphan drug that received FDA breakthrough status, while ensuring fast-track development milestones and stringent timelines.</p>
<h5><strong>5. Agilent Technologies: How to Get the Most Out Of Your Agilent GC Autosampler</strong></h5>
<p>In this Webinar we will elucidate how to get the most value from your Agilent 7693 and 7650 autosamplers. Topics will include maintainance or how to implement enhanced autosampler tools and features.</p>
<h5><strong>6. Shimadzu Scientific Instruments: Authentication of Essential Oils through Chiral GCMS</strong></h5>
<p>In this webinar we will talk about Chiral GCMS technique whis is one of the most useful and practical applications for the authentication of essential oils.</p>
<h5><strong>7. Agilent Technologies: Return to (and Keep!) Peak Performance for GC and GC/MS</strong></h5>
<p>This webinar will open the door to the secrets of mastering the signs of a dirty liner, “dead” or dirty column, and dirty MS source from everyday chromatograms, data and tune reports.</p>
<h5><strong>8. Agilent Technologies: Connecting Performance Improvement to Increased Production in GC/MS Analytical Workflows</strong></h5>
<p>Separation Science, in collaboration with Agilent, will go over some of the Ultra Inert GC columns, liners and supplies that are critical to achieve optimal performance and deliver consistent reliable results.</p>


GC and GCMS webinars - February 2021

<p><strong>In the week from February 8, 2021, the following webinars await you in the field of GC and GCMS. More <a href="https://gcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>600 GC and LC webinars</strong>.</p>
<h5><strong>1. Agilent Technologies: Accelerated PAH screening using Intuvo GC with MS Detection</strong></h5>
<p>In this webinar, by applying direct heating technology of the Intuvo GC a screening method has been developed, offering an extraordinary injection to injection time of 9 minutes.</p>
<h5><strong>2. GERSTEL: Distillers Analytical Seminar- Chromatography Technologies and Applications</strong></h5>
<p>This year’s event will feature talks for advanced whiskey analysis, smoke tainted wine detection and advanced GC-MS troubleshooting techniques. </p>
<h5><strong>3. Agilent Technologies: Analytical Labs: SLIMS Introductory Demonstration</strong></h5>
<p>This demonstration will focus on the implementation of a workflow and includes a complete round trip, from the original request to final reporting. </p>
<h5><strong>4. C&amp;EN/Agilent Technologies: Agilent OpenLab Remote Access Solutions to increase productivity</strong></h5>
<p>This webinar introduces using &quot;Thin Client&quot; technology which enables all Masshunter, ChemStation or OpenLab CDS to be accessed outside the lab, whether this is at from nearby desks, across sites, or from home. </p>


GC and GCMS webinars - Week 6

<p><strong>In the week from February 15, 2021, the following webinars await you in the field of GC and GCMS. More <a href="https://gcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>600 GC and LC webinars</strong>.</p>
<h5><strong>1. Shimadzu Scientific Instruments: Pyrolysis Application: What&#39;s In Your Sample?</strong></h5>
<p>During this webinar, we will take a look at a few key applications and we will discuss the system used, application need and show data of what it looked like run on a real system.</p>
<h5><strong>2. Agilent Technologies: The Intuvo Trifecta: One Instrument, Three Analyses- Pesticides, Residual Solvents, and Terpenes</strong></h5>
<p>This presentation will examine the evolution of Agilent’s cannabis testing workflows culminating in the Intuvo Trifecta methodologies that have shifted the paradigm of cannabis testing in the gas-phase.</p>
<h5><strong>3. Agilent Technologies: Agilent Pharma Virtual Symposium - Day 1</strong></h5>
<p>During this event, you will be able to listen to the Agilent and external experts discuss innovative solutions to address current challenges.</p>
<h5><strong>4. C&amp;EN/Eurofins CDMO Alphora: A Scientific Journey of a Niche API Achieving Breakthrough Status by the FDA for a Lifesaving Drug for Infants</strong></h5>
<p>A case study illustrating how to overcome technical challenges of an orphan drug that received FDA breakthrough status, while ensuring fast-track development milestones and stringent timelines.</p>
<h5><strong>5. Agilent Technologies: How to Get the Most Out Of Your Agilent GC Autosampler</strong></h5>
<p>In this Webinar we will elucidate how to get the most value from your Agilent 7693 and 7650 autosamplers. Topics will include maintainance or how to implement enhanced autosampler tools and features.</p>
<h5><strong>6. Agilent Technologies: Agilent Pharma Virtual Symposium - Day 2</strong></h5>
<p>During this event, you will be able to listen to the Agilent and external experts discuss innovative solutions to address current challenges.</p>
<h5><strong>7. Restek Corporation: GC Column Selection for the Analysis of Volatiles and Permanent Gases</strong></h5>
<p>In this webinar we will discuss the latest PLOT column technologies and how they can be applied for the separation of gases and volatiles.</p>
<h5><strong>8. Shimadzu Scientific Instruments: Authentication of Essential Oils through Chiral GCMS</strong></h5>
<p>In this webinar we will talk about Chiral GCMS technique whis is one of the most useful and practical applications for the authentication of essential oils.</p>


GC and GCMS webinars - Week 7

<p><strong>In the week from February 22, 2021, the following webinars await you in the field of GC and GCMS. More <a href="https://gcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>600 GC and LC webinars</strong>.</p>
<h5><strong>1. Teledyne Tekmar: Purge and Trap Workflows: Tips to Overcome Challenges That Can Arise From Sample Collection To Sample Analysis</strong></h5>
<p>Join us for this complimentary 30-minute webinar that will discuss tips to help overcome the challenges of common purge and trap methods.</p>
<h5><strong>2. Agilent Technologies: Return to (and Keep!) Peak Performance for GC and GC/MS</strong></h5>
<p>This webinar will open the door to the secrets of mastering the signs of a dirty liner, “dead” or dirty column, and dirty MS source from everyday chromatograms, data and tune reports.</p>
<h5><strong>3. INFICON: Micro GC vs. Benchtop GC</strong></h5>
<p>Our experts Debbie Alcorn and Roland Salentin are happy to talk to you about the differences but also the similarities between the MicroGC and the Benchtop GCs. </p>
<h5><strong>4. SelectScience/Agilent Technologies: Connecting Performance Improvement to Increased Production in GC/MS Analytical Workflows</strong></h5>
<p>Separation Science, in collaboration with Agilent, will go over some of the Ultra Inert GC columns, liners and supplies that are critical to achieve optimal performance and deliver consistent reliable results. </p>
<h5><strong>5. Restek Corporation: Challenge in GC column Selection</strong></h5>
<p>In this webinar we will cover 3 situations for column selection: 1. replace an existing column, 2. Improve the analysis and 3. New application.</p>


GC and GCMS webinars - Week 8

<p><strong>In the week from March 1, 2021, the following webinars await you in the field of GC and GCMS. More <a href="https://gcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>600 GC and LC webinars</strong>.</p>
<h5><strong>1. LCTech GmbH: Cannabis analysis - From Plant to Product Solution</strong></h5>
<p>In this webinar we will cover Aflatoxins and other Mycotoxins in Cannabis and Sample Clean-up for the Determinaton of Pesticide using non-dispersive QuEChERS Method.</p>
<h5><strong>2. Analytix_Ltd: Analytical pyrolysis: Opening your GC to polymer analysis</strong></h5>
<p>Analytix will be presenting a webinar on 3 March covering analytical pyrolysis and analysis of polymeric materials.</p>
<h5><strong>3. SelectScience/Agilent Technologies: Climbing the peaks of GC intelligence: Discover the smart new features in Agilent GCs</strong></h5>
<p>In this SelectScience webinar, George Reiner will introduce the new features of Agilent GC systems that have been designed to make them more intelligent and easier to use than before.</p>
<h5><strong>4. Shimadzu Scientific Instruments: Shimadzu Theory &amp; Key Principles Series - GCMS Session 5: Introduction to GCMS Method Development</strong></h5>
<p>This is the fifth webinar on fundamental concepts in GCMS. This session will cover: General method set-up, Analysis aims, Column choice, Ion selection, Improving chromatography, Improving sensitivity.</p>
<h5><strong>5. C&amp;EN/Agilent Technologies: Enabling Automated Metabolite and Lipid Extraction with the Agilent Bravo Liquid Handler</strong></h5>
<p>The Bravo Metabolomics Sample Prep Platform is built on the Bravo liquid handling system and specifically designed to prepare samples as part of the Agilent Metabolomics workflow solution.</p>


GC and GCMS webinars - Week 9

<p><strong>For this reason among other benefits, a number of gas chromatography (GC) professionals are converting to hydrogen gas using a hydrogen generator as their carrier gas supply. In this blog, we explain exactly why.</strong></p>
<h3><strong>Reliable and convenient</strong></h3>
<p>As a <strong>non-renewable resource</strong>, helium gas is becoming increasingly scarce, leading to <strong>supply shortages</strong> and an <strong>increase in costs</strong> for numerous industries, including analytical laboratories. For labs relying on helium, a lack of supply can cause delays in sample analysis and a general disruption to day-to-day workflow.</p>
<p>Working with an in-house hydrogen generator, on the other hand, is a more <strong>reliable</strong>, <strong>inexpensive</strong> and <strong>convenient</strong> way of performing GC analysis. With a hydrogen generator, labs can produce their <strong>own high purity carrier gas supply</strong> without having to depend on cylinder deliveries or go over their budget due to a sudden spike in helium prices. Once installed, a hydrogen generator stays in your lab, <strong>eliminating</strong> all the logistical hassles associated with <strong>scheduling helium gas orders</strong>, planning cylinder <strong>changeovers</strong> and <strong>installation</strong>. A gas generator provides peace of mind, knowing you have access to a constant supply of hydrogen gas and not having to worry about running out of carrier gas mid-analysis.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Peak_Scientific_Proc_prejit_v_plynove_chromatografii_z_helia_na_vodik_23e10778b1/Peak-Scientific-Proc-prejit-v-plynove-chromatografii-z-helia-na-vodik.jpg" alt="Peak Scientific: Carrier gas Hydrogen as an alternative to Helium in gas chromatography (GC)"/></p>
<h3><strong>Safe</strong></h3>
<p>Unlike a pressurized gas cylinder, a hydrogen generator <strong>does not store high volumes of gas</strong> which could pose a potential <strong>safety hazard</strong>. When working with a gas cylinder, laboratory staff have to be on the lookout for any signs of <strong>leaks</strong> or <strong>damage</strong> on the cylinder in order to prevent any explosion or fire risk due to such high volumes of pressurized gas. </p>
<p>With a hydrogen generator, however, labs can minimize these risks. A hydrogen generator will only <strong>generate the amount of hydrogen gas</strong> required <strong>to meet instrument need</strong>, meaning very small volumes of gas are stored at any one time. Performing analysis with a hydrogen generator also <strong>eliminates the requirement of transporting cylinders</strong> which could potentially be dangerous if not handled carefully.</p>
<p>Labs working with hydrogen generator can also restrict outside contact and <strong>limit Covid-19 contact transmission</strong>. Once installed, a hydrogen generator can be operated fully operated by a lab’s members of staff, allowing labs to eliminate contact with third party suppliers.</p>
<p>Beyond the absence of pressurized gas storage, a hydrogen generator comes equipped with advanced built-in fail-safe technology. These safety features prompt the hydrogen generator to <strong>shutdown in the unlikely event of a leak</strong>, maintaining safety in the lab.</p>
<h3><strong>Environmentally friendly</strong></h3>
<p>A hydrogen generator only requires a one-time delivery for installation. From then on, your hydrogen generator stays in the lab, <strong>eliminating regular cylinder deliveries</strong>, thereby reducing your lab’s overall carbon footprint.</p>
<p>Another environmentally friendly consideration is the process by which hydrogen gas is generated. A hydrogen generator <strong>produces hydrogen gas from deionized water</strong>, offering a <strong>renewable alternative</strong> to helium gas. Producing hydrogen gas from deionized water is also in contrast to the energy-intensive process of steam reformation methane, which is the most common method of obtaining cylinder hydrogen.</p>
<h3><strong>Shorter run times</strong></h3>
<p><strong>Speedier analysis</strong> is another advantage to using hydrogen gas instead of helium. Hydrogen gas has a higher optimal linear velocity than helium, therefore in many cases increasing a lab’s throughput by improving analysis speed.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Peak_Scientific_Van_Deemter_curve_732bf227c1/Peak-Scientific-Van-Deemter-curve.jpg" alt="Peak Scientific: Van Deemter curve"/></p>
<p>As demonstrated in <a href="https://www.techstreet.com/standards/jis-k-2536-4-2011?product_id=1824663"><strong>the gasoline analysis</strong></a> of <strong>Fig. 1</strong>, the analysis time <strong>was shortened</strong> with hydrogen carrier gas. Since hydrogen gas can flow gas at a lower supply pressure than helium, it is suitable for high speed analysis using <strong>a narrow bore capillary column</strong>.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Peak_Scientific_Zkraceni_analyzy_benzinu_zemenou_nosneho_plynu_helia_za_vodik_4130ab91f0/Peak-Scientific-Zkraceni-analyzy-benzinu-zemenou-nosneho-plynu-helia-za-vodik.png" alt="Fig. 1 Peak Scientific: Shortening the analysis of gasoline by changing the carrier gas helium to hydrogen "/></p>
<h3><strong>Making the switch</strong></h3>
<p>If you’re looking to convert to hydrogen gas, you need to consult <a href="https://gcms.labrulez.com/library?search=gas%20chromatography%20method%20list&amp;mainauthorItems=34"><strong>the GC Method list</strong></a> to confirm <strong>your method</strong> can indeed use hydrogen gas as an alternative to helium. It’s also important to refer to your method translation software for a <strong>simulation of the effect</strong> of changing carrier gas. There are GC instruments facilitating this conversion, such as <a href="https://www.shimadzu.com/an/products/gas-chromatography/gas-chromatograph/nexis-gc-2030/index.html"><strong>Nexis GC-2030</strong></a> by Shimadzu, which allows GC practitioners to switch carrier gas in the same sample run without adjusting any setups. You can refer to our <a href="https://gcms.labrulez.com/library?search=7%20Steps%20to%20changing%20carrier%20gas%20from%20Helium%20to%20Hydrogen&amp;mainauthorItems=34"><strong>step-by-step guide</strong></a> for more information on converting carrier gas.</p>
<p>For a safe and reliable source of hydrogen gas, Peak Scientific’s <a href="https://www.peakscientific.com/products/hydrogen/"><strong>Precision Hydrogen Trace</strong></a> range of hydrogen generators make the switch even easier with user friendly touchscreen operation. Specifically designed for GC and also suitable for <strong>FID</strong>, Precision Hydrogen Trace is available in various flow rates for all lab gas requirements, all available at a maximum purity of <strong>99.99999%</strong>. Offering greater safety, Precision Hydrogen Trace comes in a compact and space-saving design, maximizing your lab’s <strong>floorspace</strong>.  </p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/application::product.product/Peak-Precision-Hydrogen-Trace-250-500-1200-GC-Carrier-Gas-Hydrogen-Generators.jpg" alt="Peak Scientific: Hydrogen gas generator Precision Hydrogen Trace"/></p>
<p>Although helium is a popular carrier gas choice in GC, the difficulty in obtaining the gas has made more labs reconsider their gas supply, seeing an increase in the <strong>shift of carrier gas from helium to hydrogen gas</strong>. When all aspects are considered, it is easy to understand what’s driving the switch: the unrivalled <strong>reliability</strong> and <strong>peace</strong> of mind that can only be provided by a hydrogen generator.</p>


Why switch from helium to hydrogen gas for GC?

<p><strong>In the period from March 8 to March 19, 2021, the following webinars await you in the field of GC and GCMS. More <a href="https://gcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>600 GC and LC webinars</strong>.</p>
<h5><strong>1. Restek Corporation: Choosing a different carrier gas in GC</strong></h5>
<p>In this webinar we will discuss several options to choose from carrier gases in GC and what the implications are when moving from helium to nitrogen or to hydrogen.</p>
<h5><strong>2. Wasson-ECE Instrumentation: Technical Advances in Process GC-MS (8. - 11. 3. 2021)</strong></h5>
<p>Join us to learn how Wasson-ECE is bringing GC-MS out of the lab for real-time analysis of process streams. STOP WAITING for results to come back from the lab! </p>
<h5><strong>3. Agilent Technologies: 1st Agilent Lab Informatics Virtual Summit</strong></h5>
<p>In this 1-day Virtual Summit don’t miss the opportunity to hear and speak with Agilent Lab Informatics experts.</p>
<h5><strong>4. C&amp;EN/JEOL: A New Platform for GC-MS Analysis of Complex Samples</strong></h5>
<p>In this presentation, we will discuss a new, completely redesigned high-resolution time-of-flight mass spectrometer for GC-MS analysis that combines a new TOF analyzer with integrated software.</p>
<h5><strong>5. Agilent Technologies: Introduction to the Agilent 990 Micro GC</strong></h5>
<p>This webinar will discuss mobile gas chromatograph Agilent 990 Micro GC applications, hardware advancements, new wireless capabilities and the new industrial designed field case.</p>
<h5><strong>6. Shimadzu Scientific Instruments: Analysis of Siloxanes in Biogas using TD-GC-MS</strong></h5>
<p>In this webinar we will talk about analysis of Siloxanes in Biogas using TD-GC-MS (thermal desorption - gas chromatography - mass spectrometry).</p>
<h5><strong>7. PerkinElmer: Fundamentals of Thermal Desorption; Absorbing the Ins &amp; Outs</strong></h5>
<p>The theory and function of thermal desorption will be covered including differences between passive and active sampling.</p>


GC and GCMS webinars - Week 10 & 11

<p><strong>In the week from March 15, 2021, the following webinars await you in the field of GC and GCMS. More <a href="https://gcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>600 GC and LC webinars</strong>.</p>
<h5><strong>1. Agilent Technologies: 1st Agilent Lab Informatics Virtual Summit</strong></h5>
<p>In this 1-day Virtual Summit don’t miss the opportunity to hear and speak with Agilent Lab Informatics experts.</p>
<h5><strong>2. Shimadzu Scientific Instruments: Pyrolysis Ask an Expert</strong></h5>
<p>Join us for the final webinar in a three-part series about PY-GC/MS. In this webinar presented by Shimadzu, you will have the opportunity to speak with the experts! </p>
<h5><strong>3. C&amp;EN/JEOL: A New Platform for GC-MS Analysis of Complex Samples</strong></h5>
<p>In this presentation, we will discuss a new, completely redesigned high-resolution time-of-flight mass spectrometer for GC-MS analysis that combines a new TOF analyzer with integrated software.</p>
<h5><strong>4. Anatune: The Progression of SIFT-MS Through Breath and Clinical Applications - Day 1</strong></h5>
<p>Topics Day 1: An introduction; Oral malodour and its diagnosis and measurement; Validation of Electronic Nose with the SIFT-MS; Identify Differences in The Breath Volatile Profiles.</p>
<h5><strong>5. Agilent Technologies: Introduction to the Agilent 990 Micro GC</strong></h5>
<p>This webinar will discuss mobile gas chromatograph Agilent 990 Micro GC applications, hardware advancements, new wireless capabilities and the new industrial designed field case.</p>
<h5><strong>6. Anatune: The Progression of SIFT-MS Through Breath and Clinical Applications - Day 2</strong></h5>
<p>Topics Day 2: Testing Viral Filters by SIFT-MS; VOCs analysis by SIFT-MS following treatment of meat by Cold Atmospheric Plasma; Exhaled Breath Analysis Using Full-Scan SIFT-MS Data</p>
<h5><strong>7. Restek Corporation: Restek’s Workflows and Products for the Cannabis Market</strong></h5>
<p>Don’t reinvent the wheel! Join us to learn more about our testing solutions, literature and resources, and some of our first-hand experiences in this market. </p>
<h5><strong>8. Shimadzu Scientific Instruments: Analysis of Siloxanes in Biogas using TD-GC-MS</strong></h5>
<p>In this webinar we will talk about analysis of Siloxanes in Biogas using TD-GC-MS (thermal desorption - gas chromatography - mass spectrometry).</p>
<h5><strong>9. PerkinElmer: Fundamentals of Thermal Desorption; Absorbing the Ins &amp; Outs</strong></h5>
<p>The theory and function of thermal desorption will be covered including differences between passive and active sampling.</p>


GC and GCMS webinars - Week 11

<h3><strong>1. Gas Source</strong></h3>
<p><strong>Helium</strong> is becoming increasingly expensive with reports of its price having doubled in some regions between 2013 and 2015. Added to its increased price, supply cannot be ensured in certain regions which is increasing the number of labs looking to change to hydrogen.</p>
<p><strong>Hydrogen generator:</strong> A hydrogen generator providing carrier grade hydrogen (99.9999%) such as the Peak Scientific <a href="https://www.peakscientific.com/products/hydrogen/"><strong>Precision Hydrogen Trace</strong></a> is recommended as a safe source of hydrogen that will ensure prolonged column life and the highest quality of analysis.</p>
<p><strong>Supply tubing:</strong> Supply of hydrogen should be provided through new stainless steel or analytical grade copper tubing. It is important to change the tubing that was previously used to supply helium to the GC, since over time, deposits can build up on the inside of the tubing which hydrogen will strip out, causing higher background signal for a longer period of time.</p>
<h3><strong>2. Hydrogen Safety</strong></h3>
<p>Safe use of hydrogen: Since Hydrogen is an explosive gas, it is essential that health and safety in the lab is not compromised and many labs will have restrictions on the use of hydrogen cylinders in the lab.</p>
<p><strong>LEL:</strong> The lower explosive level (LEL) of hydrogen is 4% in air. Therefore a leak of hydrogen from a cylinder containing around 8000L hydrogen into a well vented laboratory has the potential to reach the LEL very quickly without warning and could create an explosive atmosphere. Added to concerns about large gas leaks, is the cumbersome nature of cylinders which must be moved when replaced, again posing a potential health and safety hazard.</p>
<p><strong>Gas Generator:</strong> A Peak Scientific Precision hydrogen generator is an ideal source of hydrogen gas, capable of supplying multiple GCs with UHP hydrogen for carrier gas and detector gas, whilst containing a very low volume of gas (less than 0.3L) at a low pressure. Precision hydrogen generators have a number of safety features that will detect any internal or external leaks between the generator and GC and will shut down the generator accordingly.</p>
<p><strong>Leak detector:</strong> Peak also offer an in-oven hydrogen detector that will shut down the generator if a significant hydrogen leak is detected within the GC oven.</p>
<h3><strong>3. Hardware</strong></h3>
<p>It is important to check the recommendations from  your  GC  manufacturer  regarding  use  of  hydrogen  carrier  gas  in  your  GC.  Each  manufacturer  will  have  tested  their  GCs  for  use  with  hydrogen  and  may  have  specific  recommendations  depending  on  the  model  that   you   are   using.   Hardware   changes,   if   required,  are  most  likely  to  need  to  be  made  on GC-MS systems.</p>
<p><strong>Vacuum Pump:</strong> If you are using a GC-MS, it is important  to  ensure  that  your  vacuum  pump  is  efficient  enough  to  maintain  the  vacuum  in  the  source.  Pumping  efficiency  is  reduced  for  lighter  molecules,  so  check  the  guidelines  from  your  GC  manufacturer  to  ensure  that  your pumping system can cope with hydrogen carrier  gas.  If  you  are  purchasing  a  new  GC-MS system, make your supplier aware that you plan  to  use  hydrogen  carrier  gas  so  that  the  correct vacuum pump is supplied.</p>
<p><strong>Ion  Source:</strong>  Depending  on  the  manufacturer  of your GC-MS, it is possible to get hydrogen upgrade kits, or replacement components for the  ion  source  which  will  improve  sensitivity  when  using  hydrogen  carrier  gas  for  analysis  of  certain  compounds.  If  you  are  purchasing  a  new  GC-MS  system,  consult  your  supplier  regarding  which  ion  source  will  be  supplied  with   the   GC-MS   to   avoid   extra   cost   and   downtime at a later date.</p>
<h3><strong>4. Consumables</strong></h3>
<p><strong>Column:</strong>  For  standard  GC,  there  is  very  little  that  needs  to  be  changed  when  switching  from  helium  to  hydrogen.  By  using  a  method  translation  software,  you  can  simulate  the  effect  of  changing  carrier  gas  on  carrier  gas  pressure and oven ramp rates so that you can produce   a   revalidated   method.   Depending   on  your  GC  method  parameters,  it  may  not  be  necessary  to  change  to  a  narrower  bore  column,  unless  the  inlet  pressure  becomes very  low  in  the  translated  method,  however  there  are  benefits  to  using  a  narrow  bore  column,  which  the  properties  of  hydrogen  carrier gas facilitates. By moving to a narrower bore column, the number of theoretical plates is  increased,  giving  potential  for  improved  efficiency and better sample separation.</p>
<p><strong>Inlet:</strong> Inlet liners should be changed regularly to   ensure   that   the   system   stays   free   of   contaminants.  When  running  samples  with  hydrogen   carrier   gas,   tapered   liners   are   recommended  since  these  minimise  contact  with  the  gold  seal  in  GC  systems  that  have  a  gold seal.</p>
<p><strong>Septa:</strong>  Changing  inlet  septa  is  a  routine  part  of GC maintenance and should be conducted regularly  to  avoid  leaks  in  the  system  and  prevent contamination.</p>
<h3><strong>5. Method</strong></h3>
<p>It is essential to confirm that your method can be  used  with  hydrogen  carrier  gas.  If  you  are  using any regulated methods (eg. EPA, ASTM), first  check  what  carrier  gases  are  permitted.  If  hydrogen  is  permitted,  then  research  your  method(s) of interest to see whether there are any application notes on this method?</p>
<p><strong>Method     translation     software:</strong>    Method     translation software is available from a variety of  sources  and  can  be  used  to  calculate  GC  settings  when  using  hydrogen  carrier  gas.  This will enable you to optimise your method and  explore  column  options  prior  to  actually  setting  the  system  up  with  hydrogen  carrier  gas.</p>
<p><strong>Use  of  chlorinated  solvents:</strong>  Formation  of  hydrochloric acid (HCl) through reaction of Cl and  H₂  is  often  cited  as  a  potential  problem  for  GC  and  GC-MS  when  using  hydrogen  carrier  gas  since  HCl  will  damage  the  GC  system.  Reactions  between  H₂  carrier  gas  and  analytes  or  solvent  will  normally  occur  in the inlet, so reducing the residence time of your  sample  in  the  inlet  is  key.  Use  of  pulsed  splitless or pulsed split injection can help with reducing residence time of sample in the inlet, reducing the opportunity for formation of HCl or  reactions  between  hydrogen  and  analytes  occurring.</p>
<p><strong>Inlet   temperature:</strong>   Using   the   lowest   inlet   temperature   possible   for   the   method   will   reduce  the  potential  for  reactions  between  solvents, analytes and hydrogen.</p>
<h3><strong>6. System setup</strong></h3>
<p><strong>Column conditioning:</strong> When setting up a new GC system with hydrogen carrier gas, you will need  to  condition  the  column.  Ensure  that  the end of the column is outside the GC oven when  you  condition  the  column  to  prevent  a  build-up  of  hydrogen  within  the  GC  oven  as  this could present a risk of explosion.</p>
<p><strong>Ion source bakeout:</strong> If you are setting up a GC-MS, it is common to see performance problems when  tuning  the  system,  or  running  samples  shortly after setting up with hydrogen carrier gas. This can be seen as high hydrocarbon-like background  and  a  high  m/z  29  peak.  Baking  out  the  ion  source  can  quickly  resolve  these  issues, with background settling down after an overnight back-out. Details of how to bake out your MSD can be found manufacturers’ guides and webinars covering use of GC-MS systems with hydrogen carrier gas.</p>
<h3><strong>7. Performance checkout</strong></h3>
<p><strong>Signal to noise:</strong> Signal to noise is often reduced when  comparing  results  of  samples  run  with  helium  compared  with  hydrogen  (2-5  times  depending  on  the  system).  The  reduction  in  signal to noise can be improved by using SIM detection on a single quadrupole system.</p>
<p><strong>Fragmentation patterns:</strong> If ion ratios change, it is likely that too much Hydrogen is present in the ion source. This problem can be mitigated by   reducing   the   column   ID   and   therefore   reducing   the   carrier   gas   flow   rate,   thus   reducing the volume of Hydrogen entering the ion source.</p>
<p><strong>Peak  tailing:</strong>  Polar  components  may  suffer  more   significantly   from   Peak   tailing   when   using  hydrogen  carrier  gas.  After  baking  out  the ion source, peak tailing should reduce and will normally reduce for most compounds after a few days.</p>
<p><strong>Background:</strong> A  few  days  following  changing  carrier gas, the background signal should drop to a consistent level.</p>
<blockquote>
<p><strong>Ed Connor Dr.Sc.</strong> is a GC Product Specialist, Peak Scientific, Inchinnan Business Park, Scotland, UK . Prior to joining Peak, Ed  completed  his  Dr.Sc.  at  ETH  Zurich  in  Switzerland  using  GC-MS to look at herbivore induced plant volatiles and their interaction with beneficial insects. He then joined the University of  Zurich  where  his  work  focused  primarily  on  volatile  collection methods and analyses using GC-MS and GC-FID.</p>
</blockquote>


7 Steps to changing carrier gas from Helium to Hydrogen

<p><strong>In the week from March 22, 2021, the following webinars await you in the field of GC and GCMS. More <a href="https://gcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>700 GC and LC webinars</strong>.</p>
<h5><strong>1. Restek Corporation: Analysis of Amines in GC</strong></h5>
<p>In this webinar we will discuss several solutions for amine analysis focusing on volatile amines as well as for amine/alcohol/water mixtures.</p>
<h5><strong>2. Separation Science/Markes International: Introducing the POD Sampler: The Latest Development in Radial Diffusive Sampling for VOCs</strong></h5>
<p>Separation Science, in collaboration with Markes International, offers a presentation covering the next generation in radial diffusive sampler – the POD Sampler.</p>
<h5><strong>3. Phenomenex: Getting Low With Sample Preparation: How to Achieve Less Background Interference and Lower Limits of Detection</strong></h5>
<p>This webinar will focus on how to develop an easy sample preparation method using solid supported liquid extraction (SLE) to achieve a fast clean-up solution from biological matrices.</p>
<h5><strong>4. GERSTEL: Enhanced Extraction using a Combination of Stir Bar Sorptive Extraction and Thin Film Solid Phase Microextraction</strong></h5>
<p>Enhanced Extraction using a Combination of SBSE and Thin Film SPME.</p>
<h5><strong>5. Quantum Analytics/Frontier Lab: Deformulation and Failure Analysis of Polymers using Pyrolysis-GC/MS</strong></h5>
<p>Learn how pyrolysis-GC/MS can deliver better efficiency and accuracy in polymer deformulation and failure analysis applications.</p>
<h5><strong>6. Anatune/GERSTEL: Aroma Analysis: Finding Flexibility in Flavour and Fragrance</strong></h5>
<p>Aroma and flavour analysis is a complex tasks and requires multiple approaches to get the most data on yours products. GERSTEL automation enables many different techniques to be used on one platform at one time.</p>
<h5><strong>7. Agilent Technologies: WAX Column Technology Update and Recent Applications</strong></h5>
<p>In this webinar, we will discuss the advances in WAX column technology, the benefits of each of these columns, and what applications they may be able to help. </p>
<h5><strong>8. VWR/Avantor: How to double your sample capacity in less time with an existing autosampler!</strong></h5>
<p>Join us to review sample handling efficiencies for LC and GC autosamplers that you can implement into your workflow.</p>
<h5><strong>9. SGS: Chemical Characterization of Medical Device Materials According to ISO 10993-18:2020</strong></h5>
<p>This presentation will focus on the analytical considerations of medical device extractable and leachable (E&amp;L) studies as per the new ISO 10993-18 chapter.</p>
<h5><strong>10. Technology Networks/Victus Capital Ventures: Uncovering the Lineage of Extraction and the Future of the Craft</strong></h5>
<p>During this webinar we will discuss the history of extraction, the most common methodologies of extraction and the technical developments of each and the future of cannabis extraction and innovations.</p>


GC and GCMS webinars - Week 12

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GC and GCMS webinars - Week 12

7 Steps to changing carrier gas from Helium to Hydrogen

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Why switch from helium to hydrogen gas for GC?

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