<p><strong>Polycyclic aromatic hydrocarbons (PAHs) are a group of organic compounds with two or more fused aromatic rings. They are found in fossil fuels and are produced by the incomplete combustion of organic matter, making them ubiquitous in the environment. Due to their potential toxic effects, including carcinogenicity and endocrine disruption, PAHs are closely monitored in the environment, especially in soil and water samples.&nbsp;</strong></p><p>However, the analysis of PAHs in environmental samples presents several challenges, particularly when adhering to stringent regulatory requirements such as the <strong>U.S. EPA Method 8270E1</strong>. In this blog, we will explore these challenges and how advanced GC-MS technology can be utilized to address and overcome these challenges.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Tackling_PAH_Analysis_in_Environmental_Samples_Overcoming_the_Challenges_with_Advanced_GC_MS_Technology_8ba846d208.jpg" alt="Thermo Fisher Scientific: Tackling PAH Analysis in Environmental Samples - Overcoming the Challenges with Advanced GC-MS Technology." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Tackling_PAH_Analysis_in_Environmental_Samples_Overcoming_the_Challenges_with_Advanced_GC_MS_Technology_8ba846d208.jpg 245w," sizes="100vw" width="1024" height="576"></p><h3 id="h-challenges-in-pah-analysis" data-uw-rm-heading="level" role="heading" aria-level="2"><strong>Challenges in PAH Analysis</strong></h3><h4 id="h-1-regulatory-compliance" data-uw-rm-heading="level" role="heading" aria-level="3"><strong>1. Regulatory Compliance</strong></h4><p>Compliance with <strong>EPA Method 8270E</strong> requires specific tuning and calibration procedures. For instance, the method mandates the use of DFTPP (Decafluorotriphenylphosphine) tuning to ensure ion abundances are within acceptable limits. Additionally, maintaining consistent instrument performance over extended runs without maintenance is crucial to meet regulatory standards and ensure results are reported in a timely manner.</p><h4 id="h-2-complex-sample-matrix"><strong>2. Complex Sample Matrix</strong></h4><p>Environmental samples including soil and wastewater are complex matrices and contain interference that can affect the accurate detection and quantification of PAHs. The presence of isobaric compounds necessitates high chromatographic resolution to distinguish between closely eluting PAH compounds, such as benzo[b]fluoranthene and benzo[k]fluoranthene.</p><h4 id="h-3-wide-range-of-detection-levels"><strong>3. Wide Range of Detection Levels</strong></h4><p>PAH analysis must cover a wide range of detection levels across different matrices, from low parts-per-billion (ppb) to high parts-per-million (ppm) concentrations. This diversity necessitates a versatile analytical method capable of maintaining accuracy and precision across a broad dynamic range. Creating and managing multiple calibration curves for different concentration ranges and matrices can be time-consuming and prone to errors.</p><h3 id="h-overcoming-the-challenges-of-pah-analysis-in-environmental-samples"><strong>Overcoming the Challenges of PAH Analysis in Environmental Samples</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Tackling_PAH_Analysis_in_Environmental_Samples_Overcoming_the_Challenges_with_Advanced_GC_MS_Technology_2_e03ef1d953.jpg" alt="Thermo Fisher Scientific: Figure 1: Chromatographic separation and peak shape for 19 investigated PAHs, 5 labelled ISTD and 2 Surrogate standards in a solvent standard at 0.1 ppm acquired in SIM. Tracks of the quantification ions are reported for each peak in different colors. 1=Naphthalene-d8, 2=Naphthalene, 3=2-methyl Naphthalene, 4=1-methyl Naphthalene, 5=Acenaphthylene, 6=Acenaphthene, 7=Acenaphtene-d10 , 8=Dibenzofuran, 9=Fluorene, 10=Tribromophenol 2,4,6, 11=Phenantrene-d10 , 12=Phenantrene, 13=Anthracene, 14=Fluoranthene, 15=Terphenyl-d14, 16=Pyrene, 17=Benz[a]anthracene, 18=Chrysene-d12, 19=Chrysene 20=Benzo[b]fluoranthene, 21=Benzo[k]fluoranthene, 22=Benzo[a]pyrene, 23=Perylene-d12, 24=Dibenzo[a,h]anthracene, 25=Indeno[1,2,3-cd] pyrene, 26=Benzo[g,h,i]perylene" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Tackling_PAH_Analysis_in_Environmental_Samples_Overcoming_the_Challenges_with_Advanced_GC_MS_Technology_2_e03ef1d953.jpg 245w," sizes="100vw" width="1024" height="552"></p><p>A PAH analysis method was fully optimized on the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/484"><strong>Thermo Scientific ISQ 7610 single quadrupole GC-MS system</strong></a>, equipped with the XLXR detector to overcome these challenges. For more information on the methods details and extensive data from the analysis you can review the full application note. The highlights of the benefits of using this GC-MS system include:</p><h4 id="h-1-wide-dynamic-range"><strong>1. Wide Dynamic Range</strong></h4><p>The XLXR detector offers an extended linear dynamic range and during this study over four orders of magnitude <strong>(2.5 ppb to 20 ppm)</strong> were covered for the <strong>19 PAHs </strong>analyzed. This wide dynamic range eliminates the need for separate calibration curves for different concentration ranges, simplifying the workflow and reducing the potential for errors.</p><p>Using a single calibration curve for multiple matrices, such as soil and water, offers significant advantages:</p><ul><li><strong>Simplified Workflow</strong>: A single calibration curve across a wide dynamic range streamlines the analytical process, reducing the time and effort required to prepare and manage multiple curves.</li><li><strong>Increased Throughput</strong>: By eliminating the need for separate curves, laboratories can analyze more samples in less time, enhancing productivity and reducing turnaround times.</li><li><strong>Improved Accuracy</strong>: Combined calibration curves minimize the potential for calibration errors, ensuring consistent and reliable quantification across different sample types.</li><li><strong>Versatility Across Matrices</strong>: The ability to use a single calibration curve for different matrices (e.g., soil and water) enhances the versatility of the analytical method, making it easier to adapt to various environmental sample types without compromising accuracy.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Tackling_PAH_Analysis_in_Environmental_Samples_Overcoming_the_Challenges_with_Advanced_GC_MS_Technology_3_3_539d6ad458.jpg" alt="Thermo Fisher Scientific: Figure 2: Examples of Average Response Factor calibration curve for some of the 19 PAHs analyzed, (from left to right: Naphthalene, Dibenzofuran, Phenantrene, Fluoranthene, Benzo[b]fluoranthene), Benzo[g,h,i]perylene, annotated with the %RSD. Linearity spans over 5 orders of magnitudes, from 2.5 to 20000 ng/mL." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Tackling_PAH_Analysis_in_Environmental_Samples_Overcoming_the_Challenges_with_Advanced_GC_MS_Technology_3_3_539d6ad458.jpg 245w," sizes="100vw" width="1024" height="640"></p><h4 id="h-2-sensitivity"><strong>2. Sensitivity</strong></h4><p>The system demonstrates excellent sensitivity with low instrument detection limits (IDLs) and method detection limits (MDLs) in the low picogram range. These detection limits exceed regulatory requirements, ensuring that even trace levels of PAHs are accurately quantified, providing reliable data for environmental monitoring.</p><h4 id="h-3-robustness"><strong>3. Robustness</strong></h4><p>The GCMS system maintained consistent sensitivity and peak shape over extended runs, with no significant performance degradation after 136 injections or 52 hours of continuous operation. This robustness is crucial for continuous operation of the system, allowing laboratories to run samples over an entire weekend without user intervention. This ensures high throughput and maximizes productivity.</p><h3 id="h-conclusion"><strong>Conclusion</strong></h3><p>The <strong>Thermo Scientific ISQ 7610 GC-MS</strong> system provides a comprehensive solution to the challenges of PAH analysis in environmental samples. Its advanced features, including a wide dynamic range, excellent sensitivity, and robust performance, ensure compliance with EPA Method 8270E and improved laboratory efficiency. By leveraging the benefits of combined calibration curves, laboratories can achieve accurate, reliable, and high-throughput PAH analysis.</p><blockquote><p>For more detailed information on the capabilities of this advanced GC-MS system, please visit the <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/gas-chromatography-mass-spectrometry-gc-ms/gc-ms-systems/single-quadrupole-gc-ms.html">ISQ 7610 GC-MS product page</a>.</p><article aria-label="Tackling PAH Analysis in Environmental Samples: Overcoming the Challenges with Advanced GC-MS Technology"><div><p><strong>Visit our&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/chromatography-&amp;-mass-spectrometry/posts/?feedView=all"><strong>LinkedIn page</strong></a><strong>: </strong>#PAHAnalysis #EnvironmentalMonitoring #GCMS</p></div></article><section><h4><strong>Adam Ladak</strong></h4><div itemprop="description">Adam Ladak is the global product marketing manager for GC quadrupole mass spectrometry at Thermo Fisher, based in the UK. He started his career working in a contracting testing lab analyzing sports supplements and horse feed for prohibited substances. He has over 20 years of experience in the analytical testing industry and has worked for leading instrument manufacturers in various roles from an application specialist to a global marketing role focused on food and environmental testing. Adam is passionate about utilizing our GCMS instrumentation to meet the customer needs and solve real world problems.</div></section></blockquote>

Tackling PAH Analysis in Environmental Samples: Overcoming the Challenges with Advanced GC-MS Technology

<p><strong>If you have had your laboratory recently fitted out with new gas lines recently, they will probably look very professional and comply </strong><a target="_blank" rel="noopener noreferrer" href="https://www.hse.gov.uk/pUbns/priced/l122.pdf"><strong>Pressure System Safety Regulations 2000</strong></a><strong> or with the </strong><a target="_blank" rel="noopener noreferrer" href="https://www.legislation.gov.uk/ukpga/1974/37/contents"><strong>Health &amp; Safety at Work Act 1974 </strong></a><strong>and with best practices from the </strong><a target="_blank" rel="noopener noreferrer" href="https://bcga.co.uk/publications/"><strong>British Compressed Gas Association</strong></a><strong> (BCGA). You may have made the decision to use gas generators which have in-built safety features. If this is not the case and you may need to have your installation inspected.</strong></p><p>The installation may terminate with one regulator or isolation valve for each gas. This may not be a problem however if you have more than one instrument or the number of instruments expand you will require separate isolation valves for each instrument. This setup enables you to keep instruments running, while maintaining or decommissioning older instruments.</p><h3><strong>Typical GC Gas Installation</strong></h3><figure class="image"><img style="aspect-ratio:941/419;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Chrom_Solutions_Analytical_Gas_Installations_ba742fee3a.jpg" alt="ChromSolutions: Analytical Gas Installations." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Chrom_Solutions_Analytical_Gas_Installations_ba742fee3a.jpg 245w," sizes="100vw" width="941" height="419"></figure><p>Also, more often than not valves and fittings to the instrument may not look so neat and tidy and could be intertwined 1/8” copper tubing. Critically this may not easily identifiable if you need to isolate, leak check, or reconfigure the gases, particularly if you have restricted access around the back of the instrument.</p><figure class="image"><img style="aspect-ratio:459/613;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Chrom_Solutions_Analytical_Gas_Installations_2_cbf39f7b65.jpg" alt="ChromSolutions: Analytical Gas Installations." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Chrom_Solutions_Analytical_Gas_Installations_2_cbf39f7b65.jpg 117w," sizes="100vw" width="459" height="613"></figure><p>Therefore, to make the identification easier <strong>ChromSolutions</strong> have developed a <strong>series of low costs products to identify valves, gas lines and sample cylinders.</strong> We have some standard 3D printing products; however, we can easily customise to <strong>gas type, valve and tag sizes to your specific requirements.</strong></p><h3><strong>Gas Line/Sample Cylinder Tags</strong></h3><p>Also printed in PLA are the<strong> gas line tags.</strong> Again they are colour coded according to<a target="_blank" rel="noopener noreferrer" href="https://bcga.co.uk/"> <strong>BCGA </strong></a><strong>– </strong><a target="_blank" rel="noopener noreferrer" href="https://bcga.co.uk/assets/BCGA%20TIS%206%20-%20Rev%203%20-%20For%20Publication.pdf"><strong>Technical information sheet 6</strong></a> : Gas cylinder identification label and colour code requirements. They will also display the <strong>gas type </strong>by its chemical symbol and can be mounted <strong>vertically or horizontally:</strong></p><figure class="image"><img style="aspect-ratio:1250/614;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Chrom_Solutions_Analytical_Gas_Installations_3_6c752f4d0f.jpg" alt="ChromSolutions: Gas Tags." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Chrom_Solutions_Analytical_Gas_Installations_3_6c752f4d0f.jpg 245w," sizes="100vw" width="1250" height="614"></figure><p>The tags provide a convenient way to easily identify the contents of gas lines. The tags are available for all commonly used laboratory gases.</p><ul><li><strong>Part Number</strong>: CS-GT-***-3D (replace *** with gas type i.e. He – Helium, O<sub>2</sub> – Oxygen etc)</li><li><strong>Product</strong>: Gas Tag</li><li><strong>Diameter (mm)</strong>: 60</li><li><strong>Height (mm)</strong>: 3</li><li><strong>Weight (g)</strong>: 6</li></ul><h3><strong>Gas Isolator Valve Box</strong></h3><p>3D printed in PLA the boxes allow mounting of an isolator valve. The box and lids are colour coded according to <a target="_blank" rel="noopener noreferrer" href="https://bcga.co.uk/"><strong>BCGA </strong></a><strong>– </strong><a target="_blank" rel="noopener noreferrer" href="https://bcga.co.uk/assets/BCGA%20TIS%206%20-%20Rev%203%20-%20For%20Publication.pdf"><strong>Technical information sheet 6</strong></a> : Gas cylinder identification label and colour code requirements. They will also display the <strong>gas type</strong> by its chemical symbol and show the <strong>on/off status</strong> of the valve. The boxes are available for<strong> all commonly used laboratory gases </strong>and can be mounted either in a vertical or horizontal orientation.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Chrom_Solutions_Analytical_Gas_Installations_4_88b53d0128.jpg" alt="ChromSolutions: 2 Way Valve Boxes." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Chrom_Solutions_Analytical_Gas_Installations_4_88b53d0128.jpg 245w," sizes="100vw" width="1289" height="377"></p><p>The boxes can be mounted either with<strong> double sided tape or screws</strong>, as single gases or as multiple boxes on a back plate. Both the individual and the single boxes can be mounted to walls or bench tops. The boxes provide a convenient way to mount an isolator valve that allows easy access and identification of the gas that the valve isolates.</p><figure class="image"><img style="aspect-ratio:756/486;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Chrom_Solutions_Analytical_Gas_Installations_5_90840d105d.jpg" alt="ChromSolutions: Valve Box." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Chrom_Solutions_Analytical_Gas_Installations_5_90840d105d.jpg 243w," sizes="100vw" width="756" height="486"></figure><figure class="image"><img style="aspect-ratio:1195/354;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Chrom_Solutions_Analytical_Gas_Installations_6_aaa6d72aac.jpg" alt="ChromSolutions: Analytical Gas Installations." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Chrom_Solutions_Analytical_Gas_Installations_6_aaa6d72aac.jpg 245w," sizes="100vw" width="1195" height="354"></figure><figure class="image"><img style="aspect-ratio:1200/753;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Chrom_Solutions_Analytical_Gas_Installations_7_1c8997096e.jpg" alt="ChromSolutions: TOGA Analyser Gas Installation with Gas Tags." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Chrom_Solutions_Analytical_Gas_Installations_7_1c8997096e.jpg 245w," sizes="100vw" width="1200" height="753"></figure><figure class="image"><img style="aspect-ratio:1209/560;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Chrom_Solutions_Analytical_Gas_Installations_8_476410e829.jpg" alt="ChromSolutions: TOGA Analyser Gas Installation with Gas Tags." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Chrom_Solutions_Analytical_Gas_Installations_8_476410e829.jpg 245w," sizes="100vw" width="1209" height="560"></figure>

Analytical Gas Installations

<p><strong>Relocating a Gas Chromatograph (GC) or a Gas Chromatograph-Mass Spectrometer (GC/MS) is a meticulous task that requires careful planning and execution to ensure the integrity and functionality of the instruments. These sophisticated analytical devices are sensitive to environmental changes, handling, and installation conditions. Below are the key considerations to keep in mind when undertaking such a move:</strong></p><h4><strong>Pre-Move Planning</strong></h4><p><strong>Evaluation and Inventory:</strong> Conduct a thorough evaluation of the current state of the instruments, including calibration status, performance metrics, and maintenance records. Then cooldown and prepare the instrument for its move. Inventory all components and accessories associated with the GC or GC/MS, ensuring nothing is overlooked during the move.</p><p><strong>Documentation:</strong> Compile detailed documentation of the current system performance, including methods used. Ensure gas connections are labelled and sealed and all other associated cables are labelled and packed.</p><h4><strong>Preparation for Transport&nbsp;</strong></h4><p><strong>Decontamination: </strong>Ensure the instrument and any associated components are properly decontaminated to prevent cross-contamination and adhere to safety regulations.</p><p><strong>Securing the Instrument: </strong>Properly shut down the system following manufacturer guidelines. Disconnect and cap all gas lines, power sources, and any other connections. Securely pack the instrument using original packaging materials if available, or suitable alternatives that provide ample protection against shocks and vibrations.</p><p><strong>Labeling and Documentation:</strong> Clearly label all parts and connections to facilitate reassembly at the new location. Prepare a detailed checklist to ensure all components are accounted for during packing, transport and re-installation</p><h4><strong>Transportation</strong></h4><p><strong>Environmental Control:</strong> Ensure that the transportation method maintains an environment within the operational temperature and humidity ranges specified by the manufacturer. If transporting the equipment a significant distance, consider using climate-controlled vehicles if necessary to protect the instrument from extreme temperatures or moisture.</p><p><strong>Handling:</strong> Engage professional movers experienced with laboratory equipment to handle the instrument with the necessary care. Avoid excessive tilting, jarring, or vibrations during transport, as these can damage sensitive components. Fit anti tilt and anti shock devices to the side of the packaging.</p><h4><strong>Reinstallation at the New Location</strong></h4><p><strong>Site Preparation: </strong>Verify that the new location meets the environmental requirements for the instrument, including appropriate temperature, humidity, ventilation, and clean power supply. Ensure that gas supplies, exhaust systems, and other necessary utilities are properly installed and functional. Gas supply pressures and purities, comply to manufacturers specifications. Ideally install clearly<strong> identified isolation valves</strong> for each instrument supply gas.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Chrom_Solutions_Analytical_Gas_Installations_7_1c8997096e.jpg" alt="ChromSolutions: TOGA Analyser Gas Installation with Gas Tags." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Chrom_Solutions_Analytical_Gas_Installations_7_1c8997096e.jpg 245w," sizes="100vw" width="1200" height="753"></p><p><strong>Personnel: </strong>Ensure re-installation personnel have relevant gas safety and electrical certificates for them and the equipment they use.</p><p><strong>Reassembly: </strong>Carefully unpack and reassemble the instrument, following the labels and documentation prepared during disassembly. Reconnect gas lines, power sources, and other connections according to the original configuration.</p><p><strong>Calibration and Testing: </strong>Perform the same thorough pre-move calibration and performance verification tests to ensure the instrument is operating correctly after reinstallation. Run standard samples to validate the accuracy and precision of the system, making any necessary adjustments to restore optimal performance.</p><h4><strong>Post-Move Monitoring and Maintenance</strong></h4><p><strong>Initial Monitoring:</strong> Closely monitor the instrument during initial operation at the new location to identify any issues that may have arisen during the move. Document any changes in performance and address them promptly.&nbsp;</p><p><strong>Routine Maintenance: </strong>Schedule routine maintenance and calibration checks to maintain the instrument's performance and longevity. Update all documentation to reflect the new location and any changes made during the reinstallation process.</p><h4><strong>Conclusion</strong></h4><p>Relocating a GC or GC/MS is a complex process that requires detailed planning and careful execution. By considering factors such as proper documentation, secure packaging, controlled transportation, and thorough reinstallation procedures, you can minimize the risks associated with the move and ensure the continued accuracy and reliability of your analytical instruments. Engaging experienced professionals and adhering to manufacturer guidelines will further enhance the success of the relocation. ChromSolutions can help customers navigate all these considerations to provide a be- spoke relocation service and a cost effective and successful outcome.</p><blockquote><p><strong>ChromSolutions Ltd&nbsp;</strong></p><p>What we offer at ChromSolutions is our wealth of experience in analytical instrument sales and support (over 120 years distributed through the members of our company). We can help you with a cost effective remote and a hybrid support agreement with the benefit of our partners</p></blockquote>

GC & GC/MS Relocation Quick Reference Guide

<p><strong>In the week from March 31, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Phenomenex: SPE Sorbent Quest: Discovering the Ideal Solution</strong></h5><ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Tuesday, April 1, 2025, 18:00 CEST</li><li style="tab-stops:list 36.0pt;"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4917">Registration</a></li></ul><p>Learn how to select the ideal SPE sorbent based on your analytes and impurities.</p><h5><strong>2. Shimadzu Corporation: Monitoring PFAS in Drinking Water with Point of Use Filtration Devices: Trusted Tap</strong></h5><ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Thursday, April 3, 2025, 20:00 CEST</li><li style="tab-stops:list 36.0pt;"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4838">Registration</a></li></ul><p>This webinar will be about using commercially available point-of-use (POU) filters as passive monitoring devices.</p><h5><strong>3. Thermo Fisher Scientific: Transforming Hydrocarbon Analysis with GC-VUV Technology</strong></h5><ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Tuesday, April 8, 2025, 18:00 CEST</li><li style="tab-stops:list 36.0pt;"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4933">Registration</a></li></ul><p>Join us for an insightful webinar to discover how Vacuum Ultraviolet (VUV) technology is transforming GC analysis of complex mixtures, delivering significant benefits to your laboratory operations.</p><h5><strong>4. Thermo Fisher Scientific: Analytical challenges and the effective management of nitrosamines: The evolving landscape of NDSRI analysis</strong></h5><ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Wednesday, April 9, 2025, 08:00 CEST</li><li style="tab-stops:list 36.0pt;"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4864">Registration</a></li></ul><p>In this online seminar we will present and discuss nitrite in excipients, nitrite and NDSRI analysis methods and challenges, NDSRI risk assessment, and a comprehensive and industry-accessible NDSRI database.</p>

Webinars LabRulezGCMS Week 14-15/2025

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 31th March 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies </strong>and<strong> Shimadzu </strong>and<strong> poster </strong>by<strong> GC Image / MDCW!</strong></p><h3><strong>1. Agilent Technologies: Navigating Global Microplastics Regulations in Drinking Water with Vibrational Spectroscopy</strong></h3><p><strong>Ensuring accurate and reliable microplastics characterization with the 8700 LDIR</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/wp_microplastics_drinking_water_regulations_8700_ldir_5994_8166en_agilent_ea9c07e61c.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Access to clean and safe drinking water is a fundamental human right and a critical public health priority. With growing concerns about environmental pollution, emerging contaminants such as microplastics have become a major focus for regulatory bodies worldwide. Microplastic particles, originating from sources such as industrial waste, packaging, and everyday consumer products, have been detected in diverse water sources, raising concerns about both their potential health risks and environmental impact.</p><p>The accurate and reliable characterization of microplastics presents significant analytical challenges due to the diversity in size, shape, and composition of these materials. Particles range from less than 20 µm to visible fragments and can exist in various forms including spheres, fibers, and irregular shapes. Microplastics are typically composed of various types of polymer, each with distinct physical and chemical properties and unique degradation histories. Because of this complexity, analyzing microplastics requires advanced analytical techniques.&nbsp;</p><p>To address these challenges, regulatory bodies and standardization organizations have actively been developing guidelines and testing methods to monitor and control microplastics contamination in drinking water. The analytical techniques used to characterize microplastics are critical in achieving accurate and reliable outcomes when studying the impact of this emerging class of contaminant. The primary techniques used to analyze microplastics fall into two categories:&nbsp;</p><ul><li><strong>Thermo-analytical methods</strong> such as thermal extraction desorption gas chromatography-mass spectrometry (TED-GC/MS) and pyrolysis-GC/MS, which provide information about polymer type and mass1&nbsp;</li><li><strong>Vibrational spectroscopy methods</strong> including Fourier transform infrared (FTIR) spectroscopy and Raman spectroscopy, which provide information about polymer type, number of particles, and size</li></ul><p>There has been an ongoing effort for several years to standardize methods for microplastic analysis using vibrational spectroscopy. These standard methods provide structured approaches that help to ensure consistent, accurate, and reproducible microplastics analysis across different laboratories and regulatory environments.&nbsp;</p><p>Three such regulatory frameworks have been established by the following bodies:&nbsp;</p><ul><li><strong>Commission Delegated Decision (EU) 2024/1441</strong>: Supplementing Directive (EU) 2020/2184 of the European Parliament and of the Council by laying down a methodology to measure microplastics in water intended for human consumption.2</li><li><strong>California Water Boards</strong>: Policy handbook establishing a standard method of testing and reporting of microplastics in drinking water, August 9, 2022.3 The policy handbook was developed in response to State of California legislation (SB1422) requiring monitoring for microplastics. As noted in the introductory text, the method is designed to "[set] forth the requirements for conducting monitoring and reporting of microplastics in drinking water." Attachment C to that document (SWB-MP1-rev1) is a Standard Operating Procedure that describes the method as relevant to IR techniques.4&nbsp;</li><li><strong>ISO/DIS 16094-2: </strong>Water Quality — Analysis of Microplastic in Water, Part 2: Vibrational spectroscopy methods for waters with low content of suspended solids including drinking water (under development).5&nbsp;</li></ul><p>ASTM WK87463 (New Test Method for Spectroscopic Identification and Quantification of Microplastic Particles in Water Using Infrared (IR) Spectroscopy) is also under development. As this method has not yet been published, it is not covered by this white paper.6</p><h4><strong>Requirements of regulatory methods</strong></h4><h5><strong>Minimum and maximum particle size&nbsp;</strong></h5><p>It is necessary to check the accuracy of any particle-sizing data generated by the analytical method used for the analysis of microplastics. The three regulatory frameworks summarized in Table 1 specify a minimum detectable particle size of 10 to 20 µm using IR spectroscopy.&nbsp;</p><p>To demonstrate the performance of the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=1&amp;search=8700+LDIR&amp;sources=GCMS_EN-ICPMS_EN"><strong>8700 LDIR</strong></a>, 10, 20, and 50 µm NIST-traceable polystyrene latex beads were measured on a low-e slide. As shown in Figure 5, particles were detected using the automated Particle Analysis workflow within the Clarity software. The method also correctly identified the type of particles, with a hit quality index (HQI) of &gt; 0.95, demonstrating the characterization capabilities of LDIR for particles as small as 10 µm. Additional details on particle sizing using gold- and aluminum-coated filters are available in other publications.8,9</p><p>As stated in Table 1, the maximum required measurement size across the three regulatory frameworks is 5 mm for particles and 15 mm for fibers per EU 2024/1441. While LDIR analyzes particles up to 500 µm, larger particles can be detected visually and measured using an Agilent <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=1&amp;sources=GCMS_EN-ICPMS_EN&amp;search=Cary+630+FTIR"><strong>Cary 630 FTIR</strong></a> spectrometer fitted with a diamond attenuated total reflectance (ATR) module (Figure 6). A fast and simple method for identifying plastic debris in this size range is reported elsewhere.10</p><h4><strong>Conclusion&nbsp;</strong></h4><p>Microplastics are widespread in the environment, exhibiting significant variation in size, shape, color, and composition, which complicates their analysis. To address these challenges, current regulatory frameworks and emerging analytical methods offer flexibility in sampling equipment, instrumentation, and data analysis techniques, provided they meet the required analytical standards. The aim of the standardized methods is to improve the accuracy and comparability of microplastic assessments. In addition to thermo-analytical methods and vibrational spectroscopy techniques such as μ-FTIR and μ-Raman, quantum cascade laser-based IR technology has proven to be a suitable technique for microplastic analysis. This white paper demonstrates how an Agilent 8700 LDIR chemical imaging system combined with Agilent Clarity software meets the requirements of the three global regulatory frameworks, enabling accurate microplastics characterization. The laser-based system offers a fully automated workflow for the direct filter-based analysis of microplastics, resulting in significant time savings and higher sample throughput compared to conventional vibrational spectroscopy techniques.</p><h3><strong>2. Shimadzu: Analysis of Neutral PFAS in Ambient Air Using Thermal Desorption GC-MS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00865_en_8dcbc95687.pdf"><strong>Full PDF for download</strong></a></li></ul><p><strong>User Benefits:</strong></p><ul><li>A thermal desorptionGC-MS system can accurately measure quantities of volatile and semivolatile per- and polyfluoroalkyl<br>substances (PFAS) in ambient air.</li><li>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=TD-30R+thermal+desorption+system"><strong>TD-30R thermal desorption system</strong></a> can perform high-throughput analysis as it does not require solvent extraction</li></ul><p>Because of the excellent heat-resistance and water-repelling properties of per- and polyfluoroalkyl substances (PFAS), they are used in many consumable products and industrial applications. However, their resistance to degradation and concerns over their persistence in the environment and toxicity to organisms mean they are increasingly regulated throughout the world. As one of the pollution routes of PFAS, the atmospheric dispersion of PFAS exhaust gas emitted from factories using PFAS is a concern. Therefore, monitoring studies have been conducted considering the risk of long-term exposure of PFAS to the respiratory system and the spread of PFAS pollution from atmosphericdispersion of PFAS.&nbsp;</p><p>Because of the tightening of PFAS regulations, analytical methods are being developed for a variety of matrices, including water, soil, and food. While most of these methods target non-volatile (ionic) PFAS and use a liquid chromatograph-mass spectrometer (LC-MS/MS), volatile or semivolatile neutral PFAS are not easily measured by these methods, so a gas chromatograph-mass spectrometer (GC-MS) is suitable forthose compounds.&nbsp;</p><p>In this Application News, the TD-30R thermal desorption system coupled to a GC-MS system (<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=GCMS-QP2020+NX"><strong>GCMS-QP2020 NX</strong></a>) measured the quantities of nine volatile and semivolatile neutral PFAS (Table 1) in ambient air.</p><h4><strong>Spike-and-Recovery Test with Ambient Air&nbsp;</strong></h4><p>Standard solutions were prepared containing 10 ng of four FTOHs and 1 ng of three FTACs and two FOSAs and these standard solutions were added to the Tenax TA/Carboxen 1000 sample tubes. 20 L of ambient air was also collected at 100 mL/min. Spike-and-recovery test and repeatability results are shown in Table 5 and SIM chromatograms are shown in Fig. 3. The recovery rates were between 77 and 106 % and all concentration %RSD (n = 3) were below 8, showing generally good performance.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The TD-30R and GCMS-QP2020 NX were used to measure quantities of nine neutral PFAS in ambient air. The measurements of standards demonstrated favorable results for sensitivity, calibration curve linearity, and repeatability for all the targeted compounds. A spike-and-recovery test with ambient air also demonstrated favorable results for recovery and repeatability. Using the TD-30R during sample pretreatment allows the sampling tube to be analyzed directly without a solvent extraction, enabling high-throughput analysis.</p><h3><strong>3. GC Image / MDCW: Interactive Ion Peak Analysis and Differencing for Comparing Multidimensional Chromatography Data</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/GC_Image_MDCW_2025_Poster_0ffa92f068.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Comprehensive two-dimensional chromatography offers superior separation capabilities for complex mixtures, but the resulting data complexity necessitates advanced comparative analysis methods. A common scenario involves comparing two samples to identify similarities and differences. We demonstrate our methods through two applications including performing new peak detection (NPD) [1] for LC-MS data of peptide samples, and identifying and comparing common and unique compounds from pairs of GCxGC-MS chromatograms.</p><h4><strong>Approach 2: Ion Peak Matching&nbsp;</strong></h4><ul><li>Find bidirectional matching between detections in both chromatograms&nbsp;</li><li>Matching criteria: matched apex within RT tolerance, matching detection ion m/z or spectral match of &gt;750&nbsp;</li></ul><h5><strong>Data Set&nbsp;</strong></h5><ul><li>GCxGC-TOFMS public data set of different dark chocolates [5]. Mint-Lime and Orange flavors are used for this demonstration. The figures presented all have MintLime on the left and Orange on the right.&nbsp;</li><li>JEOL <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=24&amp;search=AccuTof+GC"><strong>AccuTof GC</strong></a>+ mass spectrometer with an Agilent <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=7890+GC"><strong>7890 GC</strong></a></li></ul><h5><strong>Unique Peaks Filter</strong></h5><p>Significant unique ion peaks are shown using filters:</p><ul><li>‘Unmatched’ status</li><li>SNR &gt; 150</li></ul><h5><strong>Common Peaks Filter&nbsp;</strong></h5><p>Common ion peaks are shown are shown with the ‘In Both’ filter. The figure to the left shows common peaks that have a significant response difference. Filtering was done using &gt; +200% change and &lt; -50% change.&nbsp;</p><h5><strong>Peak Comparison</strong>&nbsp;</h5><p>Common compounds are matched and allow comparison between the images. The compound response values, properties, and spectra can be viewed for both samples. Unique compounds are viewed and identified, with the SIC view used to analyze the alternate chromatogram at the RT location and ion ranges.<br>&nbsp;</p>

News from LabRulezGCMS Library - Week 14, 2025

<p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5170"><strong>Get ready for Mbook 4.0!</strong></a><strong> This release introduces a modern, redesigned interface with intuitive navigation and an advanced search filtering system, making ELN management more efficient and user-friendly than ever. With a refined role architecture, enhanced experiment setup, and upgraded inventory management, Mbook 4.0 is built to optimize your laboratory workflow.</strong></p><p>With Mbook 4.0, effortlessly track projects, manage inventory, generate reports, and collaborate seamlessly - all designed to enhance efficiency and optimize every stage of your workflow. Discover the latest features and improvements below and take your chemistry lab management to the next level.</p><h4><strong>1. Modern Interface, Multi-Session, and Cross-Device Compatibility</strong></h4><p>Mbook 4.0 presents a refreshed interface with an intuitive design that simplifies navigation and enhances usability. The improved system integrates advanced filters, enabling you to efficiently search for projects, experiments, groups, users, compounds, or bottles in just a few clicks.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Figure_1a_Redesigned_Mbook_interface_3d3f9b7156.webp" alt="Mestrelab Research: Figure 1a. Redesigned Mbook interface" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Figure_1a_Redesigned_Mbook_interface_3d3f9b7156.webp 245w," sizes="100vw" width="1920" height="1080"></p><p>A major productivity boost comes with multi-session support, allowing users to open and manage multiple sessions simultaneously in separate browser tabs or windows. Effortlessly switch between projects without losing progress, compare data across different experiments, or explore your inventory while reviewing a reaction-all without losing progress.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Figure_1b_Multitasking_with_multiple_Mbook_sessions_8e72fa13db.webp" alt="Mestrelab Research: Figure 1b. Multitasking with multiple Mbook sessions" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Figure_1b_Multitasking_with_multiple_Mbook_sessions_8e72fa13db.webp 245w," sizes="100vw" width="1920" height="1080"></p><p>Additionally, Mbook is now fully compatible with web browsers on tablets and phones, providing cross-device accessibility, ensuring you can access your ELN anytime, anywhere.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Figure_1c_Mbook_accessible_across_different_devices_a5b4acfe7b.webp" alt="Mestrelab Research: Figure 1c. Mbook accessible across different devices." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Figure_1c_Mbook_accessible_across_different_devices_a5b4acfe7b.webp 245w," sizes="100vw" width="1920" height="1080"></p><h4><strong>2. Advanced Roles and Customizable Permissions</strong></h4><p>Mbook 4.0 introduces an enhanced additive role and permissions system, enabling organizations to tailor user access according to specific needs. Assign different roles to users and customize specific permissions for each role or combination of roles, ensuring improved security, seamless collaboration, and optimized workflow efficiency.</p><p>To further enhance security, new users are required to verify their email before gaining access, ensuring that only legitimate accounts are activated.</p><p>The new “Inventory manager” role has been introduced to streamline stock management, making it ideal for users dedicated to handling inventory tasks. This role can also be assigned alongside other responsibilities, offering flexibility in lab operations and ensuring more efficient resource management.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Figure_2_New_roles_and_permissions_workflow_including_the_Inventory_manager_role_a7bdbc47ae.webp" alt="Mestrelab Research: Figure 2. New roles and permissions workflow, including the Inventory manager role" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Figure_2_New_roles_and_permissions_workflow_including_the_Inventory_manager_role_a7bdbc47ae.webp 245w," sizes="100vw" width="1920" height="1080"></p><h4><strong>3. Inventory Improvements</strong></h4><p>With the new filter capabilities, locating any compound in the Compound DB or in the Stockroom is faster and more efficient, streamlining your Inventory inquiries.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Figure_3a_Advanced_filters_for_quick_compound_search_in_Mbook_Inventory_98a1763802.webp" alt="Mestrelab Research: Figure 3a. Advanced filters for quick compound search in Mbook Inventory" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Figure_3a_Advanced_filters_for_quick_compound_search_in_Mbook_Inventory_98a1763802.webp 245w," sizes="100vw" width="1920" height="1080"></p><p>Another key feature is the Bottles stock report, now available as a CSV file. This report provides a detailed overview of all bottle-related data in Mbook, allowing for more efficient inventory tracking and seamless in-situ stock verification.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Figure_3b_New_Bottles_Export_report_in_CSV_format_5cea350130.webp" alt="Mestrelab Research: Figure 3b. New Bottles Export report in CSV format" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Figure_3b_New_Bottles_Export_report_in_CSV_format_5cea350130.webp 245w," sizes="100vw" width="1920" height="1080"></p><h4><strong>4. New Experiments capabilities</strong></h4><h5><strong>Improved reaction scheme</strong></h5><p>Easily clone compounds with a single step, eliminating the need to redraw molecules and saving valuable time.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Figure_4a_9edb852456.webp" alt="Mestrelab Research: Figure 4a. Clone compounds within a reaction scheme" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Figure_4a_9edb852456.webp 245w," sizes="100vw" width="1920" height="1080"></p><h5><strong>Enhanced text editor</strong></h5><p>The experiment description section now includes:</p><ul><li><strong>New formatting options:</strong> customizable text sizes, headers, background text colors.</li><li><strong>The ability to insert images</strong>, links, formulas, tables, and quotes.</li><li><strong>Image upload support directly from your PC</strong>, tablet, or phone for quick documentation.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Figure_4b_Improved_text_editor_with_enhanced_features_d895ce7a10.webp" alt="Mestrelab Research: Figure 4b. Improved text editor with enhanced features" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Figure_4b_Improved_text_editor_with_enhanced_features_d895ce7a10.webp 245w," sizes="100vw" width="1920" height="1080"></p><h4><strong>5. Enhanced Printable Reports</strong></h4><p>All reports in Mbook have been redesigned for a more professional look, ensuring they align with your organization’s branding and compliance needs.</p><ul><li><strong>Customization Options:</strong> Display your organization’s logo or add compliance signing fields.</li><li><strong>Improved Performance</strong>: A new report engine significantly reduces generation time, allowing for faster access to reports.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Figure_5_Updated_Mbook_report_templates_6dfdb264e4.webp" alt="Mestrelab Research: Figure 5. Updated Mbook report templates" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Figure_5_Updated_Mbook_report_templates_6dfdb264e4.webp 245w," sizes="100vw" width="1920" height="1080"></p><h4><strong>6. Compound Exportation</strong></h4><p>Mbook 4.0 now supports exporting compounds from the Compound Database as CSV or SDF files. Whether you need to export a single compound or a fully configurable list, this feature provides flexibility tailored to your workflow.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Figure_6_Export_Compound_DB_as_CSV_or_SDF_files_88cde33463.webp" alt="Mestrelab Research: Figure 6. Export Compound DB as CSV or SDF files" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Figure_6_Export_Compound_DB_as_CSV_or_SDF_files_88cde33463.webp 245w," sizes="100vw" width="1920" height="1080"></p><h4><strong>7. Mnova Console Upgrade</strong></h4><p>The Mnova console in Mbook 4.0 has been updated to version 15.1, bringing enhanced data processing, visualization, and reporting capabilities.</p><ul><li><strong>Background Processing: </strong>The Mnova console now runs in the background, allowing you to continue working in Mbook while receiving a notification once processing is complete.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Figure_7_Continue_working_in_Mbook_while_Mnova_15_1_processes_data_in_the_background_24c5a3aafd.webp" alt="Mestrelab Research: Figure 7. Continue working in Mbook while Mnova 15.1 processes data in the background" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Figure_7_Continue_working_in_Mbook_while_Mnova_15_1_processes_data_in_the_background_24c5a3aafd.webp 245w," sizes="100vw" width="1920" height="1080"></p>

Mbook 4.0 What’s New – Top Features

<p><strong>In a laboratory environment, water quality plays a crucial role in conducting analytical methods, preparing chemical solutions, and ensuring the accuracy and reproducibility of experiments. Even minimal contamination can negatively impact analytical results, making it essential to ensure an appropriate level of water purity.&nbsp;</strong></p><p>Modern laboratory applications require different levels of water purification depending on the specific process requirements, and the choice of a suitable system depends on several factors, including the quality of the feed water, the required purity, the technological solution, and operational costs. This article focuses on the key aspects to consider when selecting a laboratory water purification system.</p><h4><strong>Required Water Quality&nbsp;</strong></h4><p>When selecting a water purification system, it is essential to determine the required water quality according to its intended use:&nbsp;</p><ul><li><strong>Type I (ultrapure water)</strong> – suitable for sensitive analytical methods such as HPLC, ICP-MS, or PCR.&nbsp;</li><li><strong>Type II (pure water)</strong> – used for buffer preparation, culture media, or clinical applications.&nbsp;</li><li><strong>Type III (technical water)</strong> – suitable for washing laboratory glassware, autoclaves, or other technical applications.&nbsp;</li></ul><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/download/Watrex_Water_2024.pdf?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky"><strong>View the Watrex Praha Water System Catalog.&nbsp;</strong></a></p></blockquote><h4><strong>Feed Water Quality&nbsp;</strong></h4><p>Before selecting a system, it is advisable to analyze the feed water, which may come from the municipal water supply or pre-treated sources, to allow the supplier to recommend the most suitable system for your needs. Parameters such as ion content, organic substances, and microbial contamination can influence the suitability of a specific system.&nbsp;</p><h4><strong>Purification Technologies&nbsp;</strong></h4><p>Modern water purification systems combine several technologies to achieve the required purity:&nbsp;</p><ul><li><strong>Filtration</strong> – mechanical filtration is the first step in the purification process, removing solid particles such as sediments, rust, and other mechanical impurities. Filters with different pore sizes (e.g., 5 μm or 0.2 μm) are used depending on the required water purity.&nbsp;</li><li><strong>Activated Carbon</strong> – this step removes chlorine, organic contaminants, and certain volatile organic compounds (VOCs). Activated carbon absorbs chemicals that could affect analytical methods or cause unwanted reactions.&nbsp;</li><li><strong>Reverse Osmosis (RO)</strong> – one of the most effective methods for removing dissolved salts, heavy metals, bacteria, and most organic impurities. This technology uses a semi-permeable membrane that allows water to pass through while retaining most contaminants, significantly reducing water conductivity.&nbsp;</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_10_obr_2_f34963c57b.jpg" alt="Watrex img.2: Reverse osmosis filter connection scheme. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_10_obr_2_f34963c57b.jpg 245w," sizes="100vw" width="1600" height="947"></p><ul><li><strong>Deionization (DI)</strong> – this method uses ion exchange resins to replace cations (e.g., Ca²⁺, Mg²⁺, Na⁺) and anions (e.g., Cl⁻, SO₄²⁻) with hydrogen (H⁺) and hydroxide (OH⁻) ions, resulting in nearly ion-free water. This technology is essential for producing ultrapure water.&nbsp;</li><li><strong>Ultraviolet (UV) Radiation </strong>– used for water disinfection and organic matter breakdown. UV radiation at a wavelength of 185 nm effectively reduces total organic carbon (TOC) content, while UV at 254 nm is used for bacterial and viral inactivation.&nbsp;</li><li><strong>Ultrafiltration (UF)</strong> – this technology utilizes membranes with pore sizes smaller than 0.01 μm, effectively removing bacteria, endotoxins, pyrogens, and other biological contaminants. It is essential in applications requiring the elimination of biological contamination, such as buffer preparation for cell cultures.&nbsp;</li><li><strong>Electrodeionization (EDI) </strong>– an advanced technology combining ion exchange resins with an electrochemical regenerator, enabling continuous operation without chemical regeneration. The result is water with exceptionally low conductivity and minimal contamination.&nbsp;</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_10_1_e24a944b21.jpg" alt="Watrex img.3: Types of purification technologies. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_10_1_e24a944b21.jpg 245w," sizes="100vw" width="1600" height="755"></p><p>The choice of the right combination of these technologies depends on the required water purity and its laboratory application.&nbsp;</p><h4><strong>Capacity and Flow Rate&nbsp;</strong></h4><p>The system selection should match the laboratory's daily water consumption. For example, small laboratories may require 10–50 L/day, while large research facilities may need hundreds of liters per day. The system's flow rate should be sufficient for efficient operation and rapid container filling.&nbsp;</p><h4><strong>Maintenance, Service, and Supplier Selection&nbsp;</strong></h4><p>When selecting a system, it is important to consider operating costs, including filter replacement, resin exchange, and other components. Regular maintenance is essential for maintaining optimal functionality and water quality.&nbsp;</p><p>In addition to technical parameters, the availability of spare parts and manufacturer service support should also be considered. Reputable suppliers typically offer warranty and post-warranty service, which is crucial for the long-term reliability of the system. Thanks to its own service team, <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky"><strong>Watrex Praha</strong></a> provides all needs from maintenance and service to the availability of all necessary spare parts and filters for its <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/kategorie-produktu/water-purification/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky"><strong>own water systems</strong></a> or HealForce brand water systems.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The selection of a laboratory water purification system should be carefully considered based on the specific requirements of the workplace. Key factors include the required water purity, feed water parameters, purification technologies, capacity, operating costs, and service availability. Investing in the right system ensures optimal conditions for laboratory experiments and the protection of sensitive analytical methods. At Watrex Praha, we are fully available to assist you in selecting the best solution for your needs! Contact us at watrex@watrex.com or visit our website at <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky"><strong>www.watrex.com.</strong></a></p>

Selection of a Water Purification System for the Laboratory: Key Factors and Recommendations

<p><strong>In the week from April 7, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Thermo Fisher Scientific: Transforming Hydrocarbon Analysis with GC-VUV Technology</strong></h5><ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Tuesday, April 8, 2025, 18:00 CEST</li><li style="tab-stops:list 36.0pt;"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4933">Registration</a></li></ul><p>Join us for an insightful webinar to discover how Vacuum Ultraviolet (VUV) technology is transforming GC analysis of complex mixtures, delivering significant benefits to your laboratory operations.</p><h5><strong>2. Agilent Technologies: Convert Your Deconvoluted AMDIS Libraries to *.L or Editable *.mslibrary.xml Formats to Use in MassHunter Library Searches</strong></h5><ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Tuesday, April 8, 2025, 20:00 CEST</li><li style="tab-stops:list 36.0pt;"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4957">Registration</a></li></ul><p>Join this webinar and learn a step-by-step process to convert an AMDIS library to *.L and or *.mslibrary.xml formats and how to create a deconvoluted library from MassHunter Unknowns Analysis.</p><h5><strong>3. Thermo Fisher Scientific: Analytical challenges and the effective management of nitrosamines: The evolving landscape of NDSRI analysis</strong></h5><ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Wednesday, April 9, 2025, 08:00 CEST</li><li style="tab-stops:list 36.0pt;"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4864">Registration</a></li></ul><p>In this online seminar we will present and discuss nitrite in excipients, nitrite and NDSRI analysis methods and challenges, NDSRI risk assessment, and a comprehensive and industry-accessible NDSRI database.</p><h5><strong>4. Agilent Technologies: A Look at the New MassHunter 13 Interface</strong></h5><ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Thursday, April 10, 2025, 20:00 CEST</li><li style="tab-stops:list 36.0pt;"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4958">Registration</a></li></ul><p>Join this webinar and learn what project-based organization is and the features located in the new interface (including Optimizer and RTL).</p>

Webinars LabRulezGCMS Week 15/2025

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 7th April 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you brochures by <strong>Agilent Technologies, Shimadzu, </strong>application note by<strong> Thermo Fisher Scientific </strong>and poster by<strong> University of Liège / MDCW!</strong></p><h3><strong>1. Agilent Technologies: Ensure Composition, Purity, and Calorific Value</strong></h3><p><strong>Agilent natural gas analyzers</strong></p><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/br_nga_gc_analyzer_5994_8260en_agilent_1_6070086f28.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>Produce Accurate, Reliable Data and Maximize Product Quality</strong></h4><p>Before it can be sold, natural gas must meet specifications for calorific value and purity. Accordingly, collection, processing, transmitting, and distribution require an array of analytical capabilities.</p><h5><strong>Confidently measure permanent gases and hydrocarbon content with Agilent natural gas analyzers&nbsp;</strong></h5><p>Agilent natural gas analyzers (NGAs) are based on <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=8890+GC"><strong>Agilent 8890 GC</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=990+micro+GC"><strong>990 Micro GC systems</strong></a>. Each is factory configured and chemically tested to deliver the results you need, fast, while saving you precious startup time.&nbsp;</p><p>Choose from standard or extended configurations, or for a solution for sour natural gas. Our ability to create custom analyzers, along with specialty hardware and modifications, allows you to customize a natural gas analyzer for your specific needs.</p><h4><strong>Agilent 8890 fast GC&nbsp;</strong></h4><h5><strong>Precisely analyze natural gas&nbsp;</strong></h5><p>Separating complex mixtures of hydrocarbons and permanent gases (oxygen, nitrogen, and carbon dioxide) can be difficult on a single-channel GC. The Agilent 8890 natural gas analyzer is configured for one or two channels and conforms to ASTM D1945, GPA 2261, and GPA 2286 methods.&nbsp;</p><ul><li>A second thermal conductivity detector (TCD) channel improves hydrogen detection and linearity.&nbsp;</li><li>Optional flame ionization detector (FID) enables low-level hydrocarbon analysis.&nbsp;</li><li>Customized reporting simplifies data review and processing. OpenLab CDS reporting provides calculations in mole, weight, or volume percentages, and calculated heat content. It also offers the calorific value add-on.</li></ul><h4><strong>Agilent 990 Micro GC&nbsp;</strong></h4><h5><strong>Precision results in seconds&nbsp;</strong></h5><p>Agilent 990 Micro GC natural gas analyzers cover key GPA, ISO, and GB/T methods, and they provide accurate compositional data and calculated physical properties. Their small size and mobility make them ideal for labs, pilot plants, and field work—delivering the information you need anytime, anywhere.&nbsp;</p><ul><li>Ready-to-go configuration and methods include proven hardware and software.&nbsp;</li><li>Reporting is based on standardized GPA, ISO, and GB/T calculation methods.</li><li>Options include sample pressure reduction, filtering, and automated stream selection valves.&nbsp;</li><li>Natural gas odorant monitoring is available in an optional extra channel.&nbsp;</li></ul><p>Additionally, the Agilent 990 Micro GC PRO is designed for online process environments and features onboard data collection, integration, and result generation.&nbsp;</p><ul><li>Control processes by directing automatic user-defined information to an external system.&nbsp;</li><li>Eliminate the need for an external computer by using our onboard setup feature.&nbsp;</li><li>Meet industry standards with confidence through various communication protocols, such as Modbus, FTP, and 4-20 mA.&nbsp;</li><li>Enable online monitoring of calorific value and odorants (such as THT or DMS).&nbsp;</li><li>Deliver quick analysis of dissolved gases in mud-logging during drilling operations that need to be constantly monitored.</li></ul><h4><strong>Agilent </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=GC+gasifier+"><strong>GC gasifier&nbsp;</strong></a></h4><h5><strong>Reliably introduce liquefied gas into your GC&nbsp;</strong></h5><p>The Agilent GC gasifier accessory safely controls the transition of liquefied gas to a gaseous state without discrimination or adsorption due to its inert flow path. So you can feel confident that the sample in the line is the sample being analyzed.</p><ul><li>Samples are delivered to the GC system under constant flow and pressure.&nbsp;</li><li>Control and monitor the gasifier with ease through the GC user interface.&nbsp;</li><li>Seamlessly switch between two samples—or one sample plus a calibration standard or purge gas.&nbsp;</li><li>Purge N2 gas without the need to disconnect samples</li></ul><h4><strong>Capture, analyze, and share data: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=OpenLab+CDS"><strong>OpenLab CDS</strong></a><strong> works the way you do&nbsp;</strong></h4><p>OpenLab CDS is a chromatography data system that combines productivity, usability, and the highest level of data integrity. With a single user interface, you can control your Agilent LC, GC, Micro GC, single quadrupole LC/MS, and GC/MS, as well as other vendors’ instruments in the lab, to streamline training and support. Built-in tools provide time-saving steps in analysis, interpretation, and reporting workflows while technical controls ensure work quality, effective records management, and enhanced data security.&nbsp;</p><p>Reporting for natural gas analyzers (as with refinery gas analyzers) can be done through OpenLab CDS with the built-in NGA/RGA reporting tool or through Diablo Analytical, which can take data from OpenLab CDS, ChemStation or EZChrom.&nbsp;</p><p>The OpenLab reporting feature for NGA lets you generate a custom calculation file, a constants file, and a report template for conditions defined in GPA, ASTM, or ISO standards. FPS (foot-pound-second)- based calculations (Btu) are used by GPA, ASTM, and other organizations in the United States. Metric-based calculations (meter-kilogram-second) are used for reporting natural gas composition and physical property calculations according to ISO 6976 for EU and GB/T 11062 for China.&nbsp;</p><p><strong>Note: </strong>Optionally the 990 Micro GC can be equipped with a PRO license. In this process-mode, which is usually highly automated and unattended, the instrument communicates compositional analysis results and calculated physical property data directly to a remote process computer. All data is handled on board (via browser-based access), and this does not require OpenLab CDS.</p><h3><strong>2. University of Liège / MDCW: Identification of Antifungal Volatile Organic Compounds (Vocs) from Streptomyces Scabiei 87-22 Using GC×GC-TOF-MS</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Poster_Djulia_Bensaada_workshop_a1731538ea.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Plant pathogens harm food production and the economy, while synthetic fungicides pose health and environmental risks, emphasizing the need for new alternatives.<sup>1 </sup>Streptomyces scabiei 87-22 shows promises by producing antifungal volatile organic compounds (VOCs). This study seeks to identify the VOCs responsible for their antifungal effects, with the aim to open the door to developing environmentally friendly biofungicides.<sup>2</sup>&nbsp;</p><h4><strong>Study inception</strong></h4><ul><li>In vitro experiments were conducted on Alternaria solani, Gibberella zeae, and Penicillium sp. NS1 to assess antifungal activity</li><li>Different growth conditions of Streptomyces scabiei 87-22 were evaluated</li><li>using five culture media: MHB, LB, TSB, ISP2, and ISP6&nbsp;</li></ul><h4><strong>Results and discussion</strong></h4><ul><li>20 Antifungal VOCs were identified in the different samples</li><li>VOCs production depend on the culture media</li><li>Some VOCs are inherent to the culture media</li><li>Non targeted approach is needed&nbsp;</li></ul><h4><strong>Conclusion and perspectives</strong></h4><p>Out of 25 identified VOCs, 4 demonstrated antifungal activity in vitro, highlighting their potential as antifungal agents. Conduct antifungal tests on the remaining 19 VOCs to fully evaluate their potential. Extend the study to a broader range of bacterial strains to assess their antimicrobial spectrum.</p><h3><strong>3. Shimadzu: Gas Chromatography Detector VGA-100 / VGA-101</strong></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c180_e102_01f0ccb1eb.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>Meet the alternative with a vacuum ultraviolet (VUV) detector for Gas Chromatography</strong></h4><p>The VUV (Vacuum Ultraviolet) detector is designed to collect absorption spectrum of compounds eluted from GC in the wavelength range of 120 nm to 240 nm (vacuum ultraviolet region). It consists of a deuterium lamp, ¬ow cell, grating device and detection device. Hydrocarbons, such as fuels, have strong absorption in the range of 115 nm to 185 nm (due to σ→σ* and π→→π* transitions), making the VUV detector an ideal choice for fuel analysis.&nbsp;</p><p>The VUV wavelength region is typically characterized by signi cant background absorption. Traditionally, very high-energy photons generated by a synchrotron facilities were used to obtain VUV spectrum. The VGA-100/101 VUV detector minimizes background absorption to an exceptional degree, enabling easy acquisition of VUV spectrum.</p><h4><strong>Gas Chromatography detection in a whole new light</strong></h4><h5><strong>VUV analysis system offers…</strong></h5><ul><li><strong>Identification performance specialized for fuel analysis</strong><ul><li>Full spectrum detection in the vacuum ultraviolet (VUV) wavelength region enhances identi cation performance of various hydrocarbon compounds.</li><li>Excellent oven performance of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=nexis+gc-2030"><strong>Nexis GC-2030</strong></a> improves identi cation performance with retention index.</li></ul></li><li><strong>Full compliance with ASTM official standards</strong><ul><li>A multi-method architecture that allows testing of different fuels and methods on the same analyzer without changing hardware.</li><li>Dedicated spectral libraries for various ASTM of cial methods</li></ul></li><li><strong>Enhanced analysis support functions</strong><ul><li>Time Interval Deconvolution™ (TID™) to easily deconvolve co-eluting analytes.</li><li>Push-button, automated data analysis and reporting using VUV Analyze™ Software.</li></ul></li></ul><h3><strong>4. Thermo Fisher Scientific: Thermo Scientific Orbitrap GC-MS HRAM Flavor and Fragrances Library</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ps_003097_gc_orbitrap_gc_ms_flavor_fragrances_ps003097_na_en_206f484d12.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Flavors and fragrances analysis aims to give a comprehensive characterization of samples to determine their origin (natural or synthetic), assess their quality, ensure product consistency, and comply with regulatory standards. This analysis is crucial for industries such as food, beverages, cosmetics, and perfumery to develop and maintain consistent product formulations and control. With such a high number of possible compounds, a library is an essential tool to support compound identification within a fast time frame. The Thermo Scientific™ Orbitrap™ GC-MS<strong> </strong>Flavor and Fragrances Library is a high-resolution, accuratemass (HRAM) spectral library for electron ionization (EI) GC-MS. It contains 411 compounds, which cover over eleven different chemical classes.</p><p>When used in combination with powerful Orbitrap technology and data processing tools such as <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1759"><strong>Thermo Scientific™ Compound Discoverer™ software</strong></a>, accurate flavor and fragrance identification can be quickly achieved. The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/472"><strong>Thermo Scientific™ Orbitrap Exploris™ GC mass spectrometers </strong></a>provide unique advantages for flavor and flagrance analysis over alternative instrumental techniques. Orbitrap technology allows analytical chemists to gain data certainty and achieve unprecedented selectivity using a full-scan acquisition, enabling:&nbsp;</p><ul><li>The targeting of an unlimited number of analytes down to triple quadrupole level detection limits&nbsp;</li><li>Identification of unknowns driven by spectral matching and sub-ppm mass accuracies&nbsp;</li><li>Retrospective screening of compounds not known to be of interest at time of acquisition</li></ul><p>Furthermore, the consistent sub-ppm mass accuracy delivered by the system, regardless of peak intensity, allows for confident targeting of compounds within narrow mass accuracy windows. The Thermo Scientific Orbitrap GC-MS Flavor and Fragrances Library enables a rapid and customizable set-up of a screening method, which allows users to quickly implement this powerful technology. Included in this Library are:&nbsp;</p><ul><li>High-resolution, accurate-mass spectral library acquired at 60,000 mass resolving power (FWHM m/z 200)&nbsp;</li><li>Spectra for 411 flavor compounds across eleven categories refined and curated with elemental composition of each EI fragment verified (Figure 1)&nbsp;</li><li>Compound information list showing chemical categories, odors, rendition index values, and GC column types used&nbsp;</li><li>Kovats retention index entries&nbsp;</li><li>Can be used in combination with existing unit mass libraries.&nbsp;</li></ul><p>The Orbitrap GC-MS Flavor and Fragrances Library can be used to quickly apply the theoretical masses for each analyte into a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/77"><strong>Thermo Scientific™ TraceFinder™ software</strong></a> fullscan screening or quantitation processing method. Also included for each compound is an accurate mass reference spectrum acquired on an Orbitrap GC-MS system at 60,000 resolving power.&nbsp;</p><p>This spectral library can be used as a standalone reference or in conjunction with the unknowns screening functionality of Compound Discoverer software (Figures 2 and 3) or TraceFinder software. Each software utilizes chromatographic deconvolution followed by accurate mass spectral library search to identify untargeted compounds.</p>

News from LabRulezGCMS Library - Week 15, 2025

<p><strong>In the week from April 14, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Bruker: Conserving knowledge: Non-invasive manuscript analysis by means of micro-XRF and hyperspectral imaging</strong></h5><ul><li>Tuesday, April 15, 2025, 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5014">Registration</a></li></ul><p>This webinar explores ink analysis using spatially resolved micro-XRF and recent advances in co-registering NIR transmission to determine ink composition.</p><h5><strong>2. Separation Science: Unlock New Possibilities with the Fully Loaded Brevis GC-2050: Expanded Inlets, New Detectors, Lower Costs</strong></h5><ul><li>Tuesday, April 15, 2025, 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4894">Registration</a></li></ul><h5>Join us for an insightful webinar on how the Brevis GC-2050 can transform your lab operations.</h5><h5><strong>3. Restek Corporation: GC Troubleshooting: Tips and Tricks</strong></h5><ul><li>Tuesday, April 15, 2025, 14:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4921">Registration</a></li></ul><p>In this troubleshooting session we will discuss the purpose and impact of the critical parts and setup used in split and splitless injection and how they impact your results.</p><h5><strong>4. Agilent Technologies: Create Libraries with Your Data</strong></h5><ul><li>Tuesday, April 15, 2025, 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4959">Registration</a></li></ul><p>Join this webinar and learn how to build a personal library using standards or compounds found in a sample.</p><h5><strong>5. GERSTEL: Advantages and Capabilities of the GERSTEL TDU for Sample Extraction and Introduction</strong></h5><ul><li>Tuesday, April 15, 2025, 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4922">Registration</a></li></ul><p>This webinar will illustrate the GERSTEL Thermal Desorption Unit, highlighting the hardware components, thermal desorption process, and extraction techniques with examples.</p><h5><strong>6. Agilent Technologies: Evolving Landscape on Control of Excipients Quality in Pharmaceutical Products</strong></h5><ul><li>Wednesday, April 16, 2025, 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5049">Registration</a></li></ul><p>Join this webinar to hear IPC and Agilent experts share their views on the role of Pharmacopeias in ensuring the quality of pharmaceutical products and excipients.</p><h5><strong>7. Separation Science: Switching to Hydrogen Carrier Gas: An Analyst’s Guide to GC-MS Method Conversion</strong></h5><ul><li>Wednesday, April 16, 2025, 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4877">Registration</a></li></ul><p>In this webinar, join Dr. Andreas Kapaklis and Anika Maier from TESTEX as they share their experiences in implementing hydrogen carrier gas in their thermal desorption (TD)–GC–MS workflow.</p><h5><strong>8. Agilent Technologies: Navigating Nitrosamines – Back to Basics</strong></h5><ul><li>Thursday, April 17, 2025, 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4873">Registration</a></li></ul><p>This session will help companies begin their journey with nitrosamines, covering key steps to ensure a sufficient nitrosamines risk assessment.</p><h5><strong>9. Agilent Technologies: Increase Confidence in Your Component Identification and Eliminate Components with Similar Spectra More Efficiently</strong></h5><ul><li>Thursday, April 17, 2025, 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4960">Registration</a></li></ul><p>Join this webinar and learn what retention indices (RIs) are, how they are measured, and how RIs can help minimize spectral false positives and misidentification.</p><h5><strong>10. Shimadzu Corporation: Ask Us Anything About the Analysis of PFAS</strong></h5><ul><li>Thursday, April 17, 2025, 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4839">Registration</a></li></ul><p>We will host a live panel discussion. Top experts in the field will provide their perspectives and answer your questions about PFAS testing in diverse environmental samples.</p>

Webinars LabRulezGCMS Week 16/2025

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Webinars LabRulezGCMS Week 16/2025

Selection of a Water Purification System for the Laboratory: Key Factors and Recommendations

Mbook 4.0 What’s New – Top Features

News from LabRulezGCMS Library - Week 15, 2025

Webinars LabRulezGCMS Week 15/2025

GC & GC/MS Relocation Quick Reference Guide

News from LabRulezGCMS Library - Week 14, 2025

Tackling PAH Analysis in Environmental Samples: Overcoming the Challenges with Advanced GC-MS Technology

Webinars LabRulezGCMS Week 14-15/2025

Analytical Gas Installations

Upcoming events

36th MassSpec Forum Vienna 2026

US HUPO 2026

Thermo Fisher Scientific at US HUPO 2026

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Small Size, Big Impact – High-Performance Benchtop GC and GC/MS with the Agilent 8850 GC

Dynamic Blender

Ask Me Anything About Managing Computerized System Risks to Data Integrity