<p><strong>Gas Chromatography (GC) remains a cornerstone in analytical chemistry, particularly for impurity profiling, solvent quantification, and process monitoring. But as industries face increasing complexity—whether it’s trace-level detection in pharmaceuticals or quality control in fuels—the need for more selective, sensitive, and flexible detectors has never been greater.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Shedding_Light_on_Trace_Level_Impurity_Detection_in_Modern_GC_Workflows_3cde3edd45.jpg" alt="Thermo Fisher Scientific: Shedding Light on Trace-Level Impurity Detection in Modern GC Workflows." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Shedding_Light_on_Trace_Level_Impurity_Detection_in_Modern_GC_Workflows_3cde3edd45.jpg 245w," sizes="100vw" width="1200" height="600"></p><p>GC-LUMA embeds a next-generation vacuum ultraviolet (VUV) detector that bridges the gap between the universal simplicity of an FID, the selectivity of a mass spectrometer, and the robustness required for high-throughput laboratories. This article unpacks the core insights from a recent expert webinar that explored the technology, real-world applications, and data workflows behind the GC-LUMA system.</p><h3><strong>What makes GC-LUMA unique?</strong></h3><p>The GC-LUMA detector operates in the vacuum ultraviolet (VUV) region of the electromagnetic spectrum, where virtually all organic compounds absorb light. This gives LUMA its defining feature: universal detection, with high absorption sensitivity and the ability to differentiate compounds based on their spectral fingerprints.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Shedding_Light_on_Trace_Level_Impurity_Detection_in_Modern_GC_Workflows_2_3ce03ce7c3.jpg" alt="Thermo Fisher Scientific: Shedding Light on Trace-Level Impurity Detection in Modern GC Workflows: Thermo Scientific TRACE 1610 GC equipped with LUMA detector (VUV Analytics Inc.)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Shedding_Light_on_Trace_Level_Impurity_Detection_in_Modern_GC_Workflows_2_3ce03ce7c3.jpg 242w," sizes="100vw" width="1200" height="773"></p><article><div><p>Unlike traditional VUV detectors that rely on CCD sensors, LUMA uses a 12-channel photodiode array. Each channel corresponds to a specific wavelength band (from ~118 to 240 nm), offering low-ppb sensitivity. It supports stable, linear quantification via Beer’s Law and provides spectral selectivity that enables analysts to distinguish between structurally similar compounds, such as isomers. Another practical advantage is that the LUMA detector does not require a vacuum pump, simplifying the system’s footprint and maintenance requirements. As a result, GC-LUMA allows users to extract both quantitative and qualitative information in a single run, making it a powerful and versatile tool.</p><h3><strong>GC-LUMA in practice: pharmaceutical applications</strong></h3><p><a target="_blank" rel="noopener noreferrer" href="https://catsci.com/people/dr-sam-whitmarsh/">Dr.&nbsp;Sam Whitmarsh of CatSci Ltd</a>.&nbsp;presented several practical case studies from pharmaceutical process development, where GC-LUMA proved especially valuable. In early-stage synthesis projects, such as those involving valsartan routes, GC-LUMA was used for detailed impurity profiling. The detector’s capability to combine impurity, solvent, and water analysis into a single method proved especially useful, particularly when working with compounds that are not easily detected by FID, such as hydroxylamine or water.</p><p>One compelling use case involved the deconvolution of co-eluting solvents. In scenarios mimicking worst-case chromatographic conditions, LUMA successfully resolved overlapping peaks by identifying differences in their absorbance at specific VUV wavelengths. This ability significantly reduces the need for extensive method re-optimization and enables faster turnaround in process development.</p><p><i>“LUMA gives us the selectivity of a GC-MS, but with the ease-of-use of an FID. In some cases, it’s even an order of magnitude more sensitive than FID for low-carbon or polar compounds.”</i> – <i>S. Whitmarsh</i></p><h3><strong>Water by GC: a new frontier</strong></h3><p>Traditionally, water analysis by GC presents challenges. FID cannot detect water, and manual methods like Karl Fischer titration are time-consuming and prone to variability. GC-LUMA changes this dynamic by enabling water detection as part of the routine chromatographic workflow. The detector quantifies water across a wide concentration range, from parts per million (ppm) to percent levels, and demonstrates broad linearity, for example, from 20 ppm to 2%.</p><p>Using internal standards such as tetrahydrofuran (THF), GC-LUMA enhances reproducibility while allowing simultaneous analysis of water, solvents, and impurities. This capability is particularly relevant in oligonucleotide manufacturing and other pharmaceutical contexts where precise control of residual moisture and solvent levels is critical.</p><h3><strong>Smarter data with Chromeleon CDS</strong></h3><p>As explained by <a target="_blank" rel="noopener noreferrer" href="https://theorg.com/org/vuv-analytics/org-chart/rafael-acosta">Rafael Acosta, Product Manager at VUV Analytics Inc</a>., the integration of GC-LUMA with <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/76"><strong>Thermo Scientific Chromeleon CDS</strong></a> provides a seamless data environment that enhances usability and reproducibility. With native driver integration for TRACE 1610 GC and CDS, analysts benefit from a streamlined three-step setup process that includes wavelength range selection, acquisition frequency, and channel configuration.</p><p>Chromeleon CDS further extends the power of LUMA through automatic peak purity scoring and spectral match evaluation. Users can create and manage compound libraries from reference standards and visually confirm co-elutions or potential interferences by overlaying spectral data. In one example, positional xylene isomers, which typically co-elute chromatographically, were clearly differentiated using their VUV absorbance spectra. This integration not only improves confidence in qualitative identification but also aligns with the data integrity needs of regulated environments.</p><p><i>“Chromeleon’s intuitive approach to data analysis provides a way to visualize LUMA spectra data, obtain library matching capabilities and peak purity information, which makes your method development more robust and less questionable in terms of potential coelutions.” – R. Acosta</i></p><h3><strong>All-in-one methods: a new QC paradigm</strong></h3><p>Perhaps the most compelling outcome of GC-LUMA’s flexibility is its potential to consolidate multiple quality control tests into a single analytical method. A case study involving paracetamol illustrated how GC-LUMA could be used for identity confirmation via spectral fingerprinting, assay and impurity quantification, Class 2 residual solvent detection (such as methanol and pyridine), and water determination—all within one injection.</p><p>For QA/QC laboratories, this represents a paradigm shift. By reducing the number of instruments and analytical methods required, labs can achieve greater efficiency, consistency, and throughput. It also simplifies training, documentation, and regulatory compliance.</p><p><i>“When you start to think about application in a manufacturing environment, this could be really advantageous that you’re really coalescing quite a large number of tests into one run. And that could be very effective in terms of cost and speed to release some materials and the number of pieces of equipment that you’d need to have up and running to do that” – S. Whitmarsh</i></p><h3><strong>Filling the analytical gaps</strong></h3><p>GC-LUMA doesn’t aim to replace FID or MS. Rather, it complements them by occupying a unique space in the GC detector landscape. It offers the universality of a TCD, the selectivity of an MS, and the ease of use of an FID—but with enhanced sensitivity and spectral capability. Ideal for routine labs, process development teams, and regulated QC environments, GC-LUMA delivers more than just data: it delivers clarity, confidence, and actionable insight.</p><p>With its spectral power, method simplicity, and seamless data integration, GC-LUMA provides a compelling new option for analysts seeking to elevate their GC workflows and make better-informed decisions based on richer, more reliable information.</p><blockquote><p><strong>Want to learn more?</strong> Watch the full webinar available on-demand <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5325"><strong>Shedding Light on GC‑LUMA: Revolutionizing Trace Level Impurities Detection</strong></a>, or explore technical resources at <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/chromatography/gas-chromatography-gc/gc-systems/related-products/vuv-detector.html">VUV Detector for TRACE 1600 Series GC</a></p><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong>LinkedIn:</strong></a><strong>&nbsp;</strong>#TRACE1610 #ImpurityAnalysis #GCInnovation #PharmaQAQC</p></blockquote></div></article><section><blockquote><h4><strong>Dr. Daniela Cavagnino</strong></h4><p>Dr. Daniela Cavagnino is Product Marketing Manager for GC and Sampling Solutions. She started her career in gas chromatography at Thermo Fisher Scientific spending several years in the R&amp;D laboratories working on GC technology innovation. Then, she conveyed her technical background into product management and marketing management roles with more than 20 years’ experience in promoting GC/GCMS technology and applications in several different market segments.</p></blockquote></section>

Shedding Light on Trace-Level Impurity Detection in Modern GC Workflows

<h3><strong>Introduction</strong></h3><p>In chromatographic data analysis, efficient handling of measured chromatograms is crucial for productivity and accuracy. This technical guide provides a step-by-step explanation of how to open and manage chromatograms that were measured as part of a sequence using <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><span><strong>Clarity Chromatography Software</strong></span></a>. The procedures outlined are based on a demonstration video from DataApex’s official YouTube channel and are tailored for users seeking a streamlined analytical workflow.</p><h3><strong>Tools and Software</strong></h3><ul><li><strong>Software</strong>: Clarity Chromatography Software by DataApex</li><li><strong>System Requirements</strong>: PC with sufficient RAM to handle multiple chromatograms in memory</li><li><strong>Prerequisites</strong>:<ul><li>A completed measurement sequence</li><li>Access to the Sequence and Chromatogram windows in the software</li></ul></li></ul><h3><strong>Method 1: Opening Chromatograms from the Sequence Window</strong></h3><h4><strong>Step 1: Navigate to the Sequence Window</strong></h4><ul><li>Open the <i>Sequence</i> window within Clarity.</li><li>Load a previously measured sequence.</li></ul><h4><strong>Step 2: Expand the Status Cell</strong></h4><ul><li>Locate the <strong>status cell</strong> in a row corresponding to a finished measurement.</li><li>If the row produced chromatograms, the status cell is expandable.</li><li>Click on the <strong>arrow icon</strong> in the status cell to reveal a local menu.</li></ul><h4><strong>Step 3: Select Chromatograms to Open</strong></h4><ul><li>In the local menu, select one or more chromatograms you wish to open from that row.</li><li>The chromatograms will open in <strong>overlay mode</strong>.</li></ul><h4><strong>Note on Overlay Mode</strong></h4><ul><li>Overlay mode is <strong>automatically enabled</strong> when multiple chromatograms are opened using this method.</li><li>By default, <strong>a maximum of 20 chromatograms</strong> can be opened in overlay mode.</li><li>If more chromatograms are selected, the earliest one opened will be automatically closed.</li></ul><h4><strong>Optional: Adjust the Overlay Limit</strong></h4><p>To change the default overlay limit:</p><ol><li>Go to the <strong>Instrument window</strong> menu.</li><li>Navigate to: <code>Setting</code> &gt; <code>User Options</code></li><li>In the <strong>General tab</strong>, locate the <strong>Limit</strong> section.</li><li>Adjust the maximum number of chromatograms allowed in overlay mode.</li></ol><blockquote><p>⚠️ <strong>Recommendation</strong>: Set a reasonable limit based on your system’s memory capacity. Opening too many chromatograms simultaneously can lead to performance issues.</p></blockquote><h3><strong>Method 2: Opening All Chromatograms from the Chromatogram Window</strong></h3><h4><strong>Step 1: Navigate to the Chromatogram Window</strong></h4><ul><li>Ensure that no chromatograms are currently open, or manually close them if needed.</li></ul><h4><strong>Step 2: Use the File Menu</strong></h4><ul><li>Go to the <strong>File</strong> menu.</li><li>Select <strong>Open Chromatograms from Sequence</strong> to invoke the file selection dialog.</li></ul><h4><strong>Step 3: Select and Confirm</strong></h4><ul><li>Choose the desired <strong>measured sequence</strong> from the dialog box.</li><li>Confirm the selection.</li></ul><p>All chromatograms associated with the selected sequence will now open simultaneously in the chromatogram window.</p><h3><strong>Conclusion</strong></h3><p>Clarity Chromatography Software offers flexible options for opening chromatograms measured in a sequence. Whether accessed from the Sequence window for selective viewing or from the Chromatogram window for batch loading, both approaches enhance the user’s ability to review data efficiently. By adjusting overlay settings to match system capabilities, users can tailor the experience to their specific workflow needs.</p><blockquote><p>For further video tutorials and advanced tips, visit the <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@DataapexPrague"><strong>DataApex YouTube Channel</strong></a>.</p></blockquote>

 How to open chromatograms from a sequence 

<p><strong>In this technical tip, we will address a common issue encountered in Gas Chromatography (GC) analysis: Broad solvent peaks/fronts. These distorted solvent’s peak shapes can adversely affect the accuracy and reliability of your results making determination of early eluting compounds very difficult. Let's explore possible causes and suggest remedies:</strong></p><h3><strong>Symptom: Broad solvent peaks / fronts</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Peak_Shape_Problems_Broad_Solvent_Peaks_Fronts_b4c36131a7.jpg" alt="Phenomenex: Peak Shape Problems: Broad Solvent Peaks/Fronts" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Peak_Shape_Problems_Broad_Solvent_Peaks_Fronts_b4c36131a7.jpg 245w," sizes="100vw" width="627" height="352"></p><h4><strong>Possible Cause &nbsp;/ &nbsp;Suggested Remedy</strong></h4><ul><li><strong>Bad column installation:</strong> Reinstall column.</li><li><strong>Injector leak:</strong> Find and fix leak.</li><li><strong>Injection volume too large:</strong> Decrease sample size.</li><li><strong>Injection temperature too low:</strong> Increase injection temperature so the entire sample is vaporized “instantly”. An injection temperature higher than the temperature limit of the column will not damage the column.</li><li><strong>Split ratio is too low:</strong> Increase split ratio.</li><li><strong>Column temperature too low:</strong> Increase column temperature. Use a lower boiling solvent.</li><li><strong>Initial column temperature too high for splitless injection:</strong> Decrease the initial column temperature. Use a less volatile solvent so the initial column temperature is at least 10°C below the boiling point of the solvent.</li><li><strong>Purge time too long (splitless injection):</strong> Use a shorter purge activation time.</li><li><strong>Septum purge plugged or turned off:</strong> Remove plug or turn septum purge on.</li></ul><p>By addressing these potential causes and implementing the suggested remedies, you can easily overcome the issue of broad solvent peaks/fronts, improving the peak shape and the overall accuracy of your GC analysis.</p>

Peak Shape Problems: Broad Solvent Peaks/Fronts

<h4><strong>Have you explored what’s new in </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759"><strong>Thermo Scientific Compound Discoverer software</strong></a><strong>, version 3.4?</strong></h4><p>In case you missed it, earlier this year we released version 3.4 – bringing new capabilities to small molecule researchers. Get ready to elevate your compound identification and analysis experience with this new version packed with groundbreaking features and enhancements.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Why_Compound_Discoverer_3_4_Software_is_Worth_Your_Attention_c08c06da12.jpg" alt="Thermo Fisher Scientific: Why Compound Discoverer 3.4 Software is Worth Your Attention!" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Why_Compound_Discoverer_3_4_Software_is_Worth_Your_Attention_c08c06da12.jpg 245w," sizes="100vw" width="1536" height="614"></p><article><div><h3><strong>Here’s a look at some of the key updates and why you should be excited:</strong></h3><h4><strong>1.&nbsp;LipidSearch (MKI) is now integrated</strong></h4><ul><li>The new <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1740"><strong>LipidSearch </strong></a>(MKI) node simplifies lipid identification, making it faster and more accurate. And here’s the best part: you don’t need to install separate software!</li></ul><h4><strong>2. Improved quality control for small molecule experiments</strong></h4><ul><li>A new QC node leverages internal standards to automatically detect and group in-source fragments, ensuring accurate and reliable results.</li></ul><h4><strong>3.&nbsp;Improved compound identification</strong></h4><ul><li>Connect to the latest version of the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1764"><strong>mzCloud </strong></a>Spectral database (2.0), which includes over 16.5 million spectra, 32,000 MS<sup>n</sup> trees and extensive metadata such as compound classes and CAS numbers. Providing deeper insight and better identification confidence.</li></ul><h4><strong>4.&nbsp;Performance boost</strong></h4><ul><li>Experience up to 8x faster processing speeds for various nodes, including alignment, detecting compounds, fill gaps, and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1762"><strong>mzLogic</strong></a>, ensuring that your data analysis is completed in record time.</li></ul><h4><strong>5. New spectral library and mass list parameters</strong></h4><ul><li>Now, you can use different sets of parameters for various spectral libraries or mass lists, allowing for precise matching and prioritization.</li></ul><h4><strong>6. Smarter feature detection and component assembly</strong></h4><ul><li>Separate feature detection and component assembly for greater flexibility and performance. New nodes streamline the creation of grouped feature tables and efficiently group ions and in-source fragments.</li></ul><h4><strong>7.&nbsp;New molecular networking capabilities</strong></h4><ul><li>Inject seed compounds (a compound of interest that is not present in the data set) into your molecular networks to form clusters with related compounds, helping you interpret complex networks more effectively. This feature is particularly useful for PFAS-related studies!</li></ul><h4><strong>8.</strong>&nbsp;<strong>Seamless Integration with the Thermo Scientific Ardia Platform</strong></h4><ul><li>Connect to the<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1821"><strong>Ardia Platform</strong></a> for direct raw data access and result file uploads, streamlining your workflow and enabling easy sharing of result files!</li></ul><blockquote><h3><strong>Excited to learn more?</strong></h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4863"><strong>Take a look at our webinar</strong></a> where we dive deep into these new features and demonstrate how Compound Discoverer 3.4 Software can elevate your workflows, including pesticides. &nbsp;&nbsp;</li><li>Stay ahead with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759"><strong>Compound Discoverer Software</strong></a> —where innovation meets precision!</li><li><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong>LinkedIn:</strong></a><strong>&nbsp;</strong>#CompoundDiscoverer #SmallMolecules #Software</li></ul></blockquote></div></article><section><blockquote><h5><strong>Zoe Julian</strong></h5><p>Zoe Julian is a Product Marketing Manager for Chromatography and Mass Spectrometry software at Thermo Fisher Scientific. With over 12 years' experience of working with chromatography and mass spectrometry techniques with a background in GC and GC-MS(/MS) organic environmental analysis, she has helped many laboratories and industries improve their workflows through a unique understanding of their challenges. Transitioning to a focus on Chromeleon CDS she has shown customers how software solutions can improve their productivity and support their day-to-day operations.</p></blockquote></section>

Why Compound Discoverer 3.4 Software is Worth Your Attention!

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 11th August 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you poster by <strong>Agilent Technologies / ASMS, application note </strong>by<strong> Shimadzu </strong>and technical note by<strong> Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies / ASMS: Fully Automated Workflow for Volatile PFAS Analysis in Food Contact Materials Using GC-Triple Quadrupole</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ps_7010d_pal_autusampler_pfas_asms_2025_tp_456_en_agilent_50ffdde82b.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The analysis of per- and polyfluoroalkyl substances (PFAS) in food contact materials (FCMs) is crucial due to potential health and environmental concerns. Increased PFAS testing is needed to meet public demands and new regulations. Gas Chromatography coupled with Triple Quadrupole Mass Spectrometry (GC/TQ) offers a robust and sensitive method for detecting volatile PFAS. However, manual sample preparation could pose a bottleneck, impacting lab productivity. This study presents a robust and fully automated method using the PAL3 platform with GC/TQ for quantifying more than 30 volatile PFAS in FCMs, such as paper coffee cups. The automation approach minimizes human error, improving reliability and reproducibility for routine analysis and safety assessments of PFAS in FCMs.</p><h4><strong>Experimental</strong></h4><h5><strong>Automated Sample Preparation</strong>&nbsp;</h5><p>The integrated 120 cm <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=PAL3"><strong>PAL3</strong> <strong>Series 2 RTC autosampler</strong></a><strong>,</strong> paired with the Agilent <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7010D+GC%2FMS"><strong>7010D GC/TQ</strong></a>, facilitated a fully automated PFAS quantitation workflow using a paper cup matrix. It served as an automated liquid handling platform for preparing calibration standards, extracting samples, and injecting them into the GC/TQ system, equipped with essential tools and modules.</p><h5><strong>GCMS Instrumentation&nbsp;</strong></h5><p>The 7010D GC/TQ with HES 2.0 ion source was coupled to an Agilent <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890+GC"><strong>8890 GC</strong></a> system equipped with an MMI inlet and splitless liner (p/n 5190-2293). SWARM autotune optimized the instrument settings. The Agilent 8890 GC, operated in pulsed splitless mode with a splitless inlet liner, was used for analysis. The PAL3-GC/TQ system, managed by <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=MassHunter+Acquisition+software"><strong>MassHunter Acquisition 13.0 software</strong></a>, provided an integrated single-software experience. <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=MassHunter+Optimizer"><strong>MassHunter Optimizer</strong></a> was used to obtain MRM transitions for 34 targets, along with collision energies1 . Instrument operating conditions and parameters are given in the table below</p><h4><strong>Conclusions</strong></h4><ul><li>This study demonstrated a robust, fully automated method for analyzing volatile PFAS in FCMs using the PAL3 Series 2 RTC autosampler and Agilent 7010D GC/TQ system.&nbsp;</li><li>Method detection limits (MDL), linearity, retention time (RT) precision, area precision, and QC recovery was performed to assess the workflow performance.&nbsp;</li><li>The MassHunter Optimizer simplified method development, while the HES 2.0 ion source provided exceptional sensitivity, achieving sub-ppb MDLs.&nbsp;</li><li>For all FTOHs, an LOQ of 20 μg/kg with recoveries of 65% to 135% and %RSD &lt; 10% were achieved, highlighting the high extraction efficiency, accuracy and reliability of the automated workflow.&nbsp;</li><li>Automation reduces human errors, decreases chemical usage, and enhances productivity, offering reliable trace-level volatile PFAS monitoring in FCMs for regulatory guidance.</li></ul><h3><strong>2. Shimadzu: Analysis of Benzene and Toluene by </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Brevis+GC-2050"><strong>Brevis GC-2050</strong></a><strong> Using ASTM D3606&nbsp;</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00902_en_41581fffcc.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>User Benefits</strong></h4><ul><li>Quantitation of benzene and toluene in fuels based on ASTM D3606 is possible.&nbsp;</li><li>Highly accurate backflush analysis is possible by using the SMI flow device.&nbsp;</li><li>The compact design of the Brevis GC-2050 enables space-saving in the laboratory.</li></ul><p>Benzene and toluene are widely used as feedstocks for chemical products, but due to concerns about their effects on human health, the permissible concentrations of these two compounds are specified in various regulations. ASTM D3606 1) provides two quantification methods (Procedures A and B) for benzene and toluene in automotive fuels. The corresponding concentrations of benzene and toluene are 0.12-5.2 Vol% and 0.4-19.7 Vol% when using Procedure A and 0.10-5.0 Vol% and 2.0-20.0 Vol% when using Procedure B. In this Application News article, benzene and toluene were quantified by Procedure A in ASTM D3606. Satisfactory linearity of the calibration curves and reproducibility of the quantitation values could be obtained for both compounds.</p><h4><strong>System Configuration and Analysis Conditions</strong></h4><p>Table 1 shows the system configuration and analysis conditions. The compact <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Brevis+GC-2050"><strong>Brevis GC-2050,</strong></a> with a width of about 35 cm, can contribute to space-saving in the laboratory while also demonstrating high analytical performance. In procedure A, benzene and toluene are measured with a backflush system using a capillary column. Backflush has the advantage of shortening the analysis time. Fig. 1 shows a schematic diagram of the backflush system. In addition to the FID detector (FID1) connected to the Wax analytical column, a second FID detector (FID2) which is connected to the restrictor tube, is used for monitoring to determine the timing of backflushing. The gas that flows through the columns is supplied from the injection port (SPL) and digital flow controller (AUX-APC). This is connected to discs called an SMI Flow Disc and 2-DET Splitter, which are used to split the flow to the two detectors. The SMI Flow Disc is a flow device for capillary analysis, and has the features of minimal leakage, a low dead volume, a low heat capacity, and inertness. For this reason, the device has the advantages that the temperature inside the device easily follows the temperature of the column oven, and it is also possible to analyze components with high adsorptivity. Before backflushing, the SPL pressure is set high, and during the backflush operation, the gas in the pre-column is made to flow in the reverse direction (backflushed) by changing the pressures of the SPL and AUX-APC. In this experiment, the initial backflush time was set to 3.1 min to match the elution time of toluene (Fig. 2).</p><h4><strong>Conclusion</strong></h4><p>Using the Brevis GC-2050, an analysis of benzene and toluene as specified in ASTM D3606 was conducted. The analysis time could be shortened by using a backflush system. As the quantitation values of benzene and toluene were within the standard range for both reproducibility and repeatability, satisfactory results were obtained.</p><h3><strong>3. Thermo Fisher Scientific: How NeverVent technology enables consistent uptime for continued lab operation&nbsp;</strong></h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/sl_003311_gc_vacuum_probe_interlock_nevervent_food_beverage_sl003311_na_en_529ea8c8af.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>Benefit summary&nbsp;</strong></h4><ul><li>Eliminates unnecessary downtime&nbsp;</li><li>Maintains productivity&nbsp;</li><li>Simplifies maintenance&nbsp;</li><li>Enables disruption-free ionization type change&nbsp;</li><li>Increases ROI</li></ul><h4><strong>What is NeverVent technology and how does it work?&nbsp;</strong></h4><p><strong>Thermo Scientific™ NeverVent ™ technology</strong> is unique to <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products?category=5&amp;manufacturerItems=3"><strong>Thermo Fisher Scientific’s GC-MS products</strong></a>. It allows for routine maintenance, exchange of ionization mode, and direct probe work to be performed without the need to break the vacuum of the mass spectrometer:&nbsp;</p><ul><li><strong>Removing/replacing the ionization source:</strong> Utilizing the vacuum probe interlock (VPI) in combination with an isolation valve, the ionization source can be removed the from the system without venting the MS. The source can either be cleaned or replaced with a spare clean source, and samples can be run without long stabilization times which would be required if the system was vented.&nbsp;</li><li><strong>Changing ionization type: </strong>Using the VPI, the ionization source can be replaced with a different type of ionization source, for example, switching from Electron Ionization (EI) to Chemical ionization (CI) within a few minutes.&nbsp;</li><li><strong>Using direct sampling probes: </strong>The VPI also allows the use of direct probes on some NeverVent GC-MS systems. This enables direct sampling into the MS system, bypassing the GC separation, and is useful in compound characterization and when analyzing very difficult to volatilize samples like oils or metal complexes.&nbsp;</li><li><strong>Changing the GC column without venting: </strong>When performing common column maintenance like trimming, or replacing the column entirely, the V-Lock Source Plug allows the MS to be sealed off from inside the manifold. Columns can be exchanged or maintained without ever breaking vacuum.</li></ul><h4><strong>What are the benefits to NeverVent technology?&nbsp;</strong></h4><p>NeverVent technology allows a significant increase in instrument uptime. On a traditional GC-MS when performing maintenance, such as ionization source cleaning or column exchange, the MS must be vented. Venting the MS introduces air and moisture into the system. Once the maintenance is performed, the system is then pumped back down to vacuum and a stabilization period is required to ensure air and moisture are evacuated from the system. This process often takes overnight to complete and means samples cannot be run until the following day.</p><p>&nbsp;Due to the unique design of a NeverVent GC-MS system, the vacuum is maintained which means samples can be run shortly after the maintenance is performed. This could be the difference betwen running a batch of samples overnight or waiting for a system to be ready to run. Utilizing NeverVent technology eliminates unnecessary instrument downtime due to venting the systems during maintenance, thus increasing productivity. Figure 2 highlights the time savings that can be achieved with NeverVent technology.&nbsp;</p><p>For a typical GC-MS system where maintenance on the source is performed every three months, NeverVent technology can give you an extra four days of operation per year. When adding in column and ionization mode changings, the productivity gains are even more significant.</p>

News from LabRulezGCMS Library - Week 33, 2025

<h3><strong>Introduction</strong></h3><p>The <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity Chromatography Software</strong></a> provides advanced tools for managing chromatographic sequences. Correct configuration of <strong>sequence options</strong> is crucial, as it defines how the sequence table operates, how runs are executed, and how results are stored. This article provides a step-by-step guide to setting up sequence options, based on an instructional video demonstration.</p><h3><strong>Accessing the Sequence Options Dialog</strong></h3><ol><li>Open the <strong>Sequence Window</strong>.</li><li>Select the <strong>Options</strong> icon from the toolbar, or choose the <strong>Options</strong> item from the Sequence menu.</li><li>The <strong>Sequence Options dialog</strong> will appear, containing several configurable sections.</li></ol><h3><strong>Sequence Description</strong></h3><p>At the top of the dialog, you will find a <strong>Description field</strong>. This is a free-text area where you can enter notes or identifiers for the sequence. Although optional, it is useful for documenting specific experiment details.</p><h3><strong>Sequence Mode</strong></h3><p>This section controls how Clarity handles the start of a sequence:</p><ul><li><strong>Passive Mode</strong><ul><li>Clarity waits for an external start signal (e.g., from a connected device).</li><li>Commonly used for <strong>manual injections</strong> or with <strong>uncontrolled autosamplers</strong>.</li><li>The run begins when triggered by an external event, such as turning a manual injection valve.</li></ul></li><li><strong>Active Mode</strong> <i>(default option)</i><ul><li>Clarity manages the entire process.</li><li>It waits for all devices to be ready, then signals the autosampler to inject.</li><li>Once injection is complete, the run starts automatically.</li><li>Suitable for the majority of automated workflows.</li></ul></li></ul><p>For more detailed instrument-specific settings, refer to <strong>Chapter 6 of the Getting Started Manual</strong>.</p><h4><strong>Idle Time in Active Mode</strong></h4><p>You can configure a <strong>delay (idle time)</strong> between the end of one run and the start of the next injection.<br>This feature is useful if:</p><ul><li>Devices require additional stabilization time.</li><li>Too many commands at once could cause communication issues.</li></ul><h3><strong>Sequence Row Selection</strong></h3><p>This field allows you to specify which rows in the <strong>sequence table</strong> will be executed.</p><ul><li>The software automatically sets the corresponding checkboxes in the <strong>Run column</strong>.</li><li>You may still manually adjust them afterwards.</li></ul><h3><strong>Counter Variable Settings</strong></h3><p>The <strong>counter variable</strong> can be configured here to increment automatically during the sequence.</p><ul><li>The counter can be used for labeling runs or files.</li><li>It increments with every new run in the sequence.</li><li>Depending on configuration, it may or may not reset.</li></ul><h3><strong>File Name Conflict Resolution</strong></h3><p>When multiple analyses are initiated from one row, <strong>file naming conflicts</strong> may occur. Two options are available:</p><ul><li><strong>Automatic (default)</strong><ul><li>Clarity appends a <strong>vial or injection variable</strong> to the file name, preventing duplication.</li></ul></li><li><strong>Manual</strong><ul><li>The user resolves conflicts manually before saving.</li></ul></li></ul><h3><strong>Calibration and Sequence Usage</strong></h3><p>This section allows you to define the type of <strong>calibration cloning</strong> used within the sequence.</p><ul><li>For a full explanation of calibration settings, refer to the<a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=aX-BwAXb0dI&amp;list=PLSPrHzY76_FRTmmtEUbaaQj2NrrGM3PCC"> <strong>Calibration playlist</strong></a> provided by Clarity.</li></ul><h3><strong>After Sequence Is Finished</strong></h3><p>At the end of the sequence, you can set a <strong>shutdown method</strong> for devices.</p><ul><li>For example, powering down pumps or turning off detectors.</li><li>A detailed explanation is available in the related tutorial: <i>“</i><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=B2NHqaNf05Q"><i><strong>How to Shut Down Devices After the Sequence Is Finished</strong>.</i></a><i>”</i></li></ul><h3><strong>Saving and Applying Settings</strong></h3><p>Once configuration is complete:</p><ol><li>Click <strong>OK</strong> to save the sequence options.</li><li>The parameters will apply immediately to the open sequence file.</li></ol><h3><strong>Example Configuration (from video demonstration)</strong></h3><ul><li><strong>Mode:</strong> Active</li><li><strong>Idle Time:</strong> 5 minutes</li><li><strong>Rows Executed:</strong> Only rows 2 and 4</li><li><strong>Row 4:</strong> End vial edited to allow multiple measurements</li><li><strong>File Name Conflicts:</strong> Solved automatically by appending the vial variable</li><li><strong>Counter Variable:</strong> Starts at 5, increments with each run, never resets</li></ul><h3><strong>Conclusion</strong></h3><p>Configuring sequence options in <strong>Clarity Chromatography Software</strong> ensures smooth operation, consistent data handling, and efficient automation. By mastering the settings for <strong>sequence mode, idle time, file naming, calibration, and shutdown methods</strong>, analysts can tailor workflows to specific laboratory requirements.</p><blockquote><h4><strong>For further guidance, users are encouraged to consult:</strong></h4><ul><li><strong>Chapter 6 of the Getting Started Manual</strong></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=aX-BwAXb0dI&amp;list=PLSPrHzY76_FRTmmtEUbaaQj2NrrGM3PCC"><strong>Calibration tutorials</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=B2NHqaNf05Q"><strong>Device shutdown video guide</strong></a></li></ul></blockquote>

How to set the Sequence Options in Clarity SW

<p><strong>In the week of August 18, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p class="cke-user_style-important"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p class="cke-user_style-important"><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Shimadzu Corporation: Faster, Smarter Analysis For FAMEs And Pesticides</strong></h5><ul><li>We, 20.8.2025 09:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5351">Registration</a></li></ul><p>Explore how Shimadzu’s AOC-6000 Plus and Peakintelligence AI streamline GCMS and LCMS food workflows—boosting speed, throughput, and efficiency in FAME and pesticide analysis.</p><h5><strong>2. Thermo Fisher Scientific: Chromeleon CDS connections – Exploring options for interfaces</strong></h5><ul><li>We, 20.8.2025 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5383">Registration</a></li></ul><p>Learn how to integrate Chromeleon CDS with other software to streamline workflows, boost data integrity, and enhance lab efficiency. Live Q&amp;A with Thermo Fisher experts.</p><h5><strong>3. GERSTEL: Decoding Odors - Detection and Identification</strong></h5><ul><li>Th, 21.8.2025 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5405">Registration</a></li></ul><p>Discover the GERSTEL ODP 4 and ODI software for scent detection and identification using Sensory Directed Analysis, with real-world applications and expert tips.</p><h5><strong>4. Thermo Fisher Scientific: How to process MS data in Chromeleon CDS software</strong></h5><ul><li>Th, 21.8.2025 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5362">Registration</a></li></ul><p>Join us for an insightful webinar on MS Data Processing using Thermo Scientific Chromeleon 7.3.2 software.</p><h5><strong>5. Agilent Technologies: Comprehensive Guide to GC Column Bleed: From Troubleshooting to Prevention</strong></h5><ul><li>Th, 21.8.2025 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5040">Registration</a></li></ul><p>Join us as we distinguish between abnormal and normal bleed as well share some tips and tricks to control your bleed.</p>

Webinars LabRulezGCMS Week 34/2025

<h4><strong>No Peaks - Some or all peaks are missing from the run</strong></h4><p><strong>How many times have you found that some or all peaks are suddenly missing from the run?</strong></p><p>In this month’s GC technical tip, we explore some of the possible causes and solutions to overcome peak disappearance, by evaluating three possible scenarios that should cover all possible real cases.</p><h3><strong>Symptom: All Peaks Missing</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Peak_Shape_Problems_No_Peaks_b0d5e8c344.jpg" alt="Phenomenex: Peak Shape Problems: No Peaks" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Peak_Shape_Problems_No_Peaks_b0d5e8c344.jpg 245w," sizes="100vw" width="1516" height="943"></p><h4><strong>Possible Cause &nbsp;/ &nbsp;Suggested Remedy</strong></h4><ul><li><strong>Defective or clogged syringe.:</strong> Try a new or proven syringe.</li><li><strong>“Blown” septum or massive leaks at the inlet.:</strong> Find and fix leaks.</li><li><strong>Problems with carrier gas flow.:</strong> Adjust gas flow.</li><li><strong>Column may be broken or installed in the wrong detector or inlet.:</strong> If breakage is close to the beginning or end, cut off the short piece. Breakage in the middle can be repaired with a press-fit connector. For multiple breakages, replace or reinstall the column.<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/GC_Column_Instalation_Guide_73f12586a8.pdf"><i><strong>See column installation</strong></i></a><i>.</i></li></ul></li><li><strong>The detector is not functioning or is not connected to the recorder or integrator.:</strong> Ensure detector is working properly. (e.g. is the flame in a FID lit?) Check connection to the output device.</li><li><strong>Incorrect injector temperature:</strong><ul><li><strong>Injector too cold: sample is not vaporized.: </strong>Cold injector: check injector and oven temperature with an accurate thermometer. If accurate, increase temperature as necessary, but do not exceed the maximum temperature limit of the column. Inject the sample directly onto the column.</li><li><strong>Injector too hot: thermally labile sample is decomposing.: </strong>Hot injector: check injector and oven temperature with an accurate thermometer. If accurate, reduce temperature as necessary, ensuring compatibility with sample and column minimum limit.</li></ul></li></ul><h3><strong>Symptom: No Peaks After Solvent Peak</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Peak_Shape_Problems_No_Peaks_2_5f1459f9d3.jpg" alt="Phenomenex: Peak Shape Problems: No Peaks" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Peak_Shape_Problems_No_Peaks_2_5f1459f9d3.jpg 245w," sizes="100vw" width="1481" height="943"></p><h4><strong>Possible Cause &nbsp;/ &nbsp;Suggested Remedy</strong></h4><ul><li><strong>Sample volume is too high.:</strong> Inject less sample or use a higher split ratio.</li><li><strong>For FID detectors, the flame is blown out by the solvent peak.:</strong> Check the detector temperature.</li><li><strong>Carrier gas flow is too high.:</strong> Reduce the flow rate.</li><li><strong>Incorrect column temperature; column is too hot and sample is eluting in solvent peak.:</strong> Check oven temperature with an accurate thermometer. If accurate, reduce temperature as necessary, ensuring compatibility with sample and column minimum limit.</li><li><strong>Column cannot separate components from solvent.:</strong> Change solvent or column.</li></ul><h3><strong>Symptom: Some Peaks Missing</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Peak_Shape_Problems_No_Peaks_3_be7fd462a8.jpg" alt="Phenomenex: Peak Shape Problems: No Peaks" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Peak_Shape_Problems_No_Peaks_3_be7fd462a8.jpg 245w," sizes="100vw" width="1453" height="886"></p><h4><strong>Possible Cause &nbsp;/ &nbsp;Suggested Remedy</strong></h4><ul><li><strong>Activity in the inlet liner or column if the missing peak is an active compound.:</strong> Clean or replace the inlet liner. Ensure an inert column is used. If necessary, replace the column. <i><strong>See column installation</strong>.</i></li></ul><p>When some or all peaks are missing in a GC analysis most causes are related to the detector, which plays a crucial role, but do not dismiss other possible causes, such as a defective syringe, an improper injection or an activated column or liner.</p><p>See you on the next technical tip, feel free to contact us if you need support in troubleshooting or for your method development.</p>

Peak Shape Problems: No Peaks

<p><strong>Gas chromatography (GC) is one of the most widely used analytical techniques in chemistry, pharmaceuticals, food safety, and environmental monitoring. A GC system typically consists of an autosampler, injector, columns, detectors, and a data system. Each of these modules plays a critical role in ensuring accurate, reproducible separations and quantitation.</strong></p><p>Like any complex instrument, GC systems are subject to wear and tear. Certain components are exposed to high temperatures, corrosive gases, and mechanical stress, making them more prone to failure.</p><h4><strong>Which Parts Break Down Most Often and Why?</strong></h4><ul><li><strong>Inlets (Split/Splitless, PTV, On-Column):</strong> High thermal cycling, septum punctures, and contamination from dirty samples can damage inlet bodies, liners, and seals.</li><li><strong>EPC Modules (Electronic Pneumatic Control):</strong> Precision electronics and valves regulating carrier and detector gases are sensitive to leaks, dirt, and aging, leading to flow instability.</li><li><strong>Detectors (ECD, FID, SCD, NCD):</strong> Detector assemblies rely on delicate components such as filaments, burners, or electrodes, which degrade over time.</li><li><strong>Oven Components:</strong> Fans, heaters, and exhaust deflectors can fail due to prolonged high-temperature operation.</li><li><strong>Electronic Boards and Power Supplies:</strong> Provide stable operation for all modules; aging components can lead to intermittent failures.</li></ul><h4><strong>What Needs to Be Replaced Frequently?</strong></h4><ul><li><strong>Septum and liners:</strong> Daily to weekly, depending on use.</li><li><strong>O-rings, seals, ferrules:</strong> Regular wear items, replaced as part of routine maintenance.</li><li><strong>Detector components (ECD cells, FID jets, SCD/NCD burners):</strong> Replaced when signal stability drops.</li><li><strong>EPC modules and valves:</strong> Every few years, or when gas flows become unstable.</li></ul><p>Proactive replacement of these consumable and wear parts prevents downtime and ensures your GC delivers consistent results.</p><h3><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=366"><strong>Offered GC Spare Parts</strong></a></h3><h5><strong>1.&nbsp;Agilent: Quartz Heater Burner XCD, G3488-60203 (Tested)</strong></h5><p>Quartz heater burner for Agilent 8355/8255 xCD detectors. Provides stable high-temperature combustion for accurate sulfur and nitrogen detection in GC chemiluminescence analysis.</p><ul><li><strong>Price:</strong> €1,900.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/483">Detailed offer can be found here</a></li></ul><h5><strong>2. Agilent: ECD EPC Manifold for GC 7890, G3433-60533 (Tested)</strong></h5><p>EPC manifold ensures precise gas flow to the ECD for stable and sensitive halogen compound analysis. OEM part for optimal performance.</p><ul><li><strong>Price:</strong> €2,250.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/481">Detailed offer can be found here</a></li></ul><h5><strong>3. Agilent: GC 6890 EPC Flow Control Module, G1531-69720 (Tested)</strong></h5><p>EPC flow control module for Agilent 6890 GC. Ensures precise carrier gas regulation for consistent chromatographic performance. Ideal for service or system restoration.</p><ul><li><strong>Price:</strong> €1,650.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/480">Detailed offer can be found here</a></li></ul><h5><strong>4. Agilent: SSL Manifold Assembly, G3452-60852 (Tested)</strong></h5><p>Critical mechanical and pneumatic subassembly used in Agilent GC/MS systems equipped with a Split/Splitless inlet.</p><ul><li><strong>Price: </strong>€1,650.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/459">Detailed offer can be found here</a></li></ul><h5><strong>5. Agilent: SSL with EPC Assembly, 100 PSI for 8890 GC, G3547-60100 (Refurbished)</strong></h5><p>High-pressure SSL inlet with EPC for Agilent 8890 GC, supporting split/splitless modes, precise flow control, and fast heating—ideal for trace-level and routine GC applications.</p><ul><li><strong>Price:</strong> €2,900.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/433">Detailed offer can be found here</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Agilent_SSL_with_EPC_Assy_100_PSI_for_8890_GC_ab9e45f919.jpg" alt="Agilent: SSL with EPC Assembly, 100 PSI for 8890 GC, G3547-60100" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Agilent_SSL_with_EPC_Assy_100_PSI_for_8890_GC_ab9e45f919.jpg 208w," sizes="100vw" width="1600" height="1200"></p><h5><strong>6. Agilent: 8890 EPC Module, Cool On-Column, G3450-60405 (New)</strong></h5><p>EPC module designed for precise carrier gas regulation in Agilent 8890 GC systems equipped with a Cool On-Column (COC) inlet.</p><ul><li><strong>Price:</strong> €2,200.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/402">Detailed offer can be found here</a></li></ul><h5><strong>7. Agilent: GC Exhaust Deflector, G1530-80650 (New)</strong></h5><p>Exhaust deflector assembly safely redirects heated exhaust from the oven fan away from surrounding components in Agilent GC systems.</p><ul><li><strong>Price: </strong>€250.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/400">Detailed offer can be found here</a></li></ul><h5><strong>8. Agilent: Split/Splitless Inlet Module incl. EPC for GC 7890, G3452-60800 (New)</strong></h5><p>Complete inlet with EPC module for Agilent 7890 GC, ensuring consistent and accurate sample injection.</p><ul><li><strong>Price: </strong>€2,600.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/394">Detailed offer can be found here</a></li></ul><h5><strong>9. Agilent: DPS-B Digital Power Supply Board, 01050-69374 (New)</strong></h5><p>Core electronic module responsible for providing regulated power and digital control interfaces to key subsystems within Agilent GC instruments.</p><ul><li><strong>Price</strong>: €300.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/363">Detailed offer can be found here</a></li></ul><h5><strong>10. Agilent: Split/Splitless Inlet Body, G3452-64000 (New / Refurbished)</strong></h5><p>Split/Splitless inlet body including heater/sensor and insulation, designed for use with Agilent 7890 GC systems.</p><ul><li><strong>Condition:</strong> New</li><li><strong>Price: </strong>€3,400.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/358">Detailed offer can be found here</a></li><li><strong>Condition:</strong> Refurbished</li><li><strong>Price:</strong> €2,600.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/327">Detailed offer can be found here</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Agilent_Technologies_Split_Splitless_inlet_body_2_fcdc711b29.jpg" alt="Agilent: Split/Splitless Inlet Body, G3452-64000" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Agilent_Technologies_Split_Splitless_inlet_body_2_fcdc711b29.jpg 215w," sizes="100vw" width="1597" height="1161"></p><h5><strong>11. Agilent: Deactivated Sample Probe for G1888 Headspace Sampler, 2322700011 (New)</strong></h5><p>Deactivated sample probe for the G1888 headspace sampler ensuring clean transfer of volatiles with minimal adsorption for accurate GC analysis.</p><ul><li><strong>Price:</strong> €250.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/551">Detailed offer can be found here</a></li></ul><h5><strong>12. Agilent: Small Circuit Board for 7694 Headspace Sampler, 415-305-HSP (New)</strong></h5><p>Small circuit board for the 7694A headspace sampler; detects carousel position for accurate vial alignment and reliable automated handling.</p><ul><li><strong>Price:</strong> €250.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/550">Detailed offer can be found here</a></li></ul><h5><strong>13. Agilent: Sample Vial Motor Drive Belt for 7694 Headspace Sampler, 301-010-HSP (New)</strong></h5><p>Motor drive belt for the 7694A headspace sampler; ensures smooth vial handling and dependable autosampling.</p><ul><li><strong>Price:</strong> €120.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/549">Detailed offer can be found here</a></li></ul><h5><strong>14. Agilent: Temperature Controller Board for G1888A Headspace Sampler, 3411500113 (New)</strong></h5><p>Temperature controller board (replaces board #1 or #2) for stable temperature control and reliable sample heating in the G1888A.</p><ul><li><strong>Price: </strong>€350.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/548">Detailed offer can be found here</a></li></ul><h5><strong>15. Agilent: Horizontal Loader Drive Belt for 7694 Headspace Sampler, 301-007-HSP (New)</strong></h5><p>Horizontal loader drive belt for the 7694A; enables smooth vial transfer and reliable automated sample handling.</p><ul><li><strong>Price: </strong>€95.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/547">Detailed offer can be found here</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Agilent_Horizontal_loader_drive_belt_for_7694_headspace_sampler_301_007_HSP_2_6d8335ed2c.jpg" alt="Agilent: Horizontal Loader Drive Belt for 7694 Headspace Sampler, 301-007-HSP" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Agilent_Horizontal_loader_drive_belt_for_7694_headspace_sampler_301_007_HSP_2_6d8335ed2c.jpg 208w," sizes="100vw" width="1700" height="1275"></p><h5><strong>16. Agilent: Syringe Motor Assembly for 7673 ALS, 07673-60890 (New)</strong></h5><p>Syringe motor assembly for 7673A/7673B/G1513A ALS; delivers precise syringe control for consistent automated injections.</p><ul><li><strong>Price:</strong> €215.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/546">Detailed offer can be found here</a></li></ul><h5><strong>17. Agilent: Turret Motor Assembly for 7673 ALS, G1513-60810 (New)</strong></h5><p>Turret motor assembly for 7673 ALS G1513A; ensures precise vial positioning for reliable automated injections.</p><ul><li><strong>Price:</strong> €215.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/545">Detailed offer can be found here</a></li></ul>

Keep Your GC Running: Essential Spare Parts for Every Lab

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 18th August 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you poster by <strong>Agilent Technologies / ASMS </strong>and application note<strong> </strong>by<strong> Shimadzu!</strong></p><h3><strong>1. Agilent Technologies / ASMS: New Pollutant Screening of Environmental Samples Using High-Resolution GC/Q-TOF and Accurate Mass Spectral Library of Emerging Environmental Pollutants&nbsp;</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ps_7250_pdcl_library_pal3_suremass_asms_2025_thp_083_en_agilent_3f1ac53d50.pdf"><strong>Full PDF for download</strong></a></li></ul><p>This paper conducts qualitative and semi - quantitative analysis of complex GC/Q-TOF sample data by using high-resolution, accurate-mass gas chromatography/quadrupole time-of-flight mass spectrometry (GC/Q-TOF), an accurate mass spectral library of environmental pollutants specifically created for emerging pollutant screening, and analytical software with a screening process platform. Actual environmental water samples are used to verify the sensitivity, accuracy, and spiked recovery rate of the solution. All results confirm that this solution is simple, stable, and effective, providing technical support for emerging pollutant screening.</p><h4><strong>Experimental</strong></h4><h5><strong>Instrument Analysis&nbsp;</strong></h5><p>The samples were analyzed by <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890+GC"><strong>Agilent 8890 GC</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7250+GC%2FQ-TOF"><strong>7250 high resolution accurate mass GC/Q-TOF system</strong></a>, It was configurated with a mid-column backflush setup (Figure 1). A 55.5 - min retention time locked GC oven temperature program is utilized which is listed in Table 1. The key mass spectrometry parameters of the GC/Q-TOF are as follows: It operates in the Electron Ionization (EI) mode with an energy of 70 electron volts, conducts detection in the time-of-flight scan mode within a mass-to-charge ratio range of 50 - 1000. The spectral acquisition rate is 5 Hz, and both the interface temperature and the source temperature are set at 280 °C. Data analysis is performed with the assistance of MassHunter data analysis software. The high-resolution accurate mass spectral library employed in the screening process is independently created by the laboratory.</p><h5><strong>Data Analysis&nbsp;</strong></h5><ul><li>The data processing used Agilent <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=Masshunter+software"><strong>Masshunter data analysis software</strong></a>, including Suremass.&nbsp;</li><li>The target screening of new pollutants was based on an independently created by the laboratory GC/Q-TOF PCDL library<sup>1</sup>.</li></ul><h4><strong>Conclusions&nbsp;</strong></h4><ul><li>Based on the currently collected list of new pollutants, a truly meaningful new pollutant PCDL high-resolution spectral library has been created.&nbsp;</li><li>This work demonstrated a total workflow for targeted screening and semi-quantification in real water sample.&nbsp;</li><li>The confidence in identification of new pollutants was enhanced by stable RT and excellent mass accuracy as a result of using an RTL backflush method and highresolution accurate mass measurement.</li></ul><h3><strong>2. Shimadzu: Analysis of SAF Using Comprehensive Two- Dimensional Gas Chromatography (GC× GC)&nbsp;</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00862_en_f1ee0a435f.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>User Benefits</strong></h4><ul><li>By comparing chromatograms obtained as two-dimensional images, it can be utilized for quality control Inspection of SAF.</li><li>Changing the column combination customizes separation characteristics to the sample composition.</li><li>Utilizing the FASST (Fast Automated Scan/SIM Type) allows for the simultaneous analysis of the composition of SAF and the quantitative analysis of antioxidants.</li></ul><p>SAF (Sustainable Aviation Fuel) produced from waste cooking oil, used paper, and sugarcane has gained attention in recent years from the perspective of achieving a carbon neutral society. The physical properties of SAF,such as combustibility, vary depending on its components. Therefore, component analysis of SAF is crucial; however, since SAF is a mixture of various hydrocarbons, complete separation of each component is extremely challenging. Comprehensive two-dimensional gas chromatography (GC×GC), which utilizes the separation characteristics of two different types of columns, is an effective method for analyzing SAF with such a complex composition. Additionally, the GCMS-QP2050 enables ultra-fast scanning (30,000 u/sec), which improves the separation of adjacent peaks and allows for high-precision qualitative analysis(Application News No.01-00788-EN).</p><p>In this application, two types of SAF (A and B) and one intermediate product from the SAF production process (C) were measured using a combination of GC×GC with a non-polar column as the first column and a medium-polarity column as the second column. The two-dimensional images allow for a visual representation of the composition distribution, making quality control Inspection. Moreover, high separation of paraffins and naphthenes using a combination of a medium-polar column as the first column and a non-polar column asthe second column, as well as the quantification of antioxidants in SAF, which are regulated by concentration in ASTM D2425 will be introduced.</p><h5><strong>System Configuration</strong></h5><ul><li><strong>GC Model</strong>: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexis%E2%84%A2+GC-2030"><strong>Nexis GC-2030</strong></a> / <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=AOC-30i"><strong>AOC-30i</strong></a></li><li><strong>MS Model</strong>: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-QP2050"><strong>GCMS-QP2050</strong></a> (TMP exhaust: 255 L/sec)</li><li><strong>Injection Port</strong>: SPL</li><li><strong>Modulator: </strong>ZX1 thermal modulator (ZOEX corp.)</li><li><strong>Nitrogen generator: </strong>MT-24F (System Instruments Co., Ltd.)</li><li><strong>Software</strong>:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Labsolutions+GCMS"><strong>Labsolutions<sup>TM</sup> GCMS</strong></a></li><li>GC Image (GC Image, LLC)</li></ul></li><li><strong>Library: </strong>NIST Mass Spectral Library</li></ul><h4><strong>Conclusion</strong></h4><p>Three SAF samples were measured using a combination of lowpolar to medium polar columns and compared the twodimensional images. The two-dimensional images allow for intuitive comprehension of the distribution of each component, making it easy to identify differences in composition and conducting quality control Inspection. Additionally, in the measurement of SAF using a combination of medium-polar to non-polar columns, the separation of paraffins and naphthenes was improved. Furthermore, by utilizing the FASST, composition analysis of SAF and quantitative analysis of antioxidants were simultaneously performed, which are regulated by concentration in ASTM D2425.</p>

News from LabRulezGCMS Library - Week 34, 2025

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News from LabRulezGCMS Library - Week 34, 2025

Peak Shape Problems: No Peaks

How to set the Sequence Options in Clarity SW

Why Compound Discoverer 3.4 Software is Worth Your Attention!

Keep Your GC Running: Essential Spare Parts for Every Lab

Webinars LabRulezGCMS Week 34/2025

News from LabRulezGCMS Library - Week 33, 2025

Peak Shape Problems: Broad Solvent Peaks/Fronts

How to open chromatograms from a sequence

Shedding Light on Trace-Level Impurity Detection in Modern GC Workflows

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36th MassSpec Forum Vienna 2026

US HUPO 2026

Pittcon 2026

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Food contaminant testing: Powerful workflow solutions for evolving residue analysis - from pesticides to PFAS

Small Size, Big Impact – High-Performance Benchtop GC and GC/MS with the Agilent 8850 GC

Dynamic Blender