Bioanalytical samples often need pretreatment before SPE. Each matrix presents challenges like protein removal, red blood cell lysis, glucuronide hydrolysis, or tissue homogenization.

Learn how GC column dimensions—length, internal diameter (ID), and film thickness—impact resolution, sensitivity, capacity, and run time for better method optimization.

Solid phase extraction enables clean-up, pre-concentration, and solvent switching. Proper solvent choice and SPE mode are key for effective solid sample preparation.

What parameters should I consider when selecting a GC column for my application?

How much sample can I load onto my SPE device? Is it linked to the concentration of my analyte of interest?

This whitepaper explains how to calculate the content of fatty acid methyl esters (FAME) and the linoleic acid methyl ester in biodiesel fuel according to ISO 14103 in Clarity.

Gas Chromatography (GC) Column Conditioning, Testing and Checks

How is normal phase (NP) SPE different from reversed phase (RP) SPE? How do I decide which one to use?

When installing your capillary GC column, making accurate connections is essential to ensure trouble free operation. In this technical tip we provide advice on the best way to achieve this.

Explore solvent and pH conditions for Reversed Phase, Normal Phase, and Strong Ion-Exchange SPE. Guidelines cover analyte types, sample matrices, and key steps from conditioning to elution.