<p><strong>At the forefront of global anti-doping efforts, the Laboratoire Anti-Dopage Français (LADF) plays a critical role in ensuring fair play and integrity in elite sports. We spoke with Dr. Magnus Ericsson, Director of LADF and a leading expert in analytical chemistry, to explore how the lab detects banned substances, manages high-throughput workflows, and leverages advanced Thermo Fisher Scientific technologies to stay ahead of constantly evolving challenges in anti-doping science.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Inside_Laboratoire_Anti_Dopage_Francais_LADF_An_Interview_with_Director_Dr_Magnus_Ericsson_6aca8272d5.jpg" alt="Thermo Fisher Scientific: Inside Laboratoire Anti-Dopage Français (LADF): An Interview with Director Dr. Magnus Ericsson" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Inside_Laboratoire_Anti_Dopage_Francais_LADF_An_Interview_with_Director_Dr_Magnus_Ericsson_6aca8272d5.jpg 245w," sizes="100vw" width="1024" height="512"></p><article><div><h3><strong>Screening and confirmation: A rigorous two-step approach</strong></h3><p>Every year, LADF analyzes tens of thousands of biological samples using a workflow aligned with World Anti-Doping Agency (WADA) guidelines. This two-step process—screening and confirmation—forms the backbone of modern doping analysis.<br><br>During the screening phase, high-throughput, non-targeted assays detect a broad spectrum of compounds. This aligns with recent advancements in mass spectrometry that allow LC-HRAM (high-resolution accurate mass) systems to scan for hundreds of substances in a single run, ensuring rapid and comprehensive coverage of the WADA Prohibited List <sup>(1)</sup>.<br><br>Suspicious samples then undergo confirmation testing using validated targeted methods that meet WADA’s stringent sensitivity and specificity criteria. LADF employs the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/485"><strong>Thermo Scientific TSQ 9610 Triple Quadrupole GC-MS/MS system</strong></a> for this task. Introduced in 2023, this triple quadrupole instrument has already supported the analysis of over 40,000 urine samples, ensuring reliable confirmatory data.<br><br><i>“The TSQ 9610 mass spectrometer has helped us to improve our workflow in the lab,”</i> says Dr. Ericsson. <i>“We started using it in 2023 and today we have analyzed more than 40,000 samples… with great success.”</i><br><br>Implementation of <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/77"><strong>Thermo Scientific TraceFinder software</strong></a> has also enabled seamless software continuity with LADF’s existing LC-MS and GC-MS platforms—minimizing training needs and ensuring consistent operations.</p><h3><strong>Unlocking historical insights with retrospective analysis</strong></h3><p>Modern anti-doping labs benefit not just from real-time detection but also from retrospective analysis, enabled by HRAM technology. LADF leverages the high-resolution <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/403"><strong>Thermo Scientific Orbitrap Exploris 120 mass spectrometer</strong></a> to re-mine stored HRAM data and search for newly -banned substances.<br><br>This capability aligns with a broader trend in doping control. HRAM instruments now routinely provide resolution &gt;60,000 FWHM and mass accuracy &lt;2 ppm, allowing researchers to revisit past datasets and identify emerging doping agents without reanalyzing physical samples (1).<br><br><i>“Working with high-resolution mass spectrometry, we have the possibility to go back and search in previously analyzed data,” </i>Dr. Ericsson explains.<br><br>Retrospective analysis is becoming increasingly vital as WADA continues to expand its list of monitored substances.</p><h3><strong>Speeding up turnaround times without sacrificing accuracy</strong></h3><p>During major competitions, laboratories are under intense pressure to deliver results rapidly. LADF tackles this challenge using <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/742"><strong>Thermo Scientific Vanquish Duo UHPLC</strong></a> paired with the Orbitrap Exploris 120 mass spectrometer, enabling parallel workflows and multiplexed analyses in 96-well formats.<br><br><i>“We are able to save maybe a couple of hours of time. And this is a huge benefit for us,”</i> notes Dr. Ericsson.<br><br>Recent advances support this approach. New UHPLC and HRAM technologies allow scan-to-scan polarity switching at &gt;1 Hz, making it possible to detect a wide array of acidic and basic substances simultaneously—significantly speeding up comprehensive screening workflows <sup>(1)</sup>.</p><h3><strong>Building toward a one-stop shop</strong></h3><p>LADF aims to become a true “one-stop shop” for anti-doping services—mirroring Thermo Fisher Scientific’s role as their trusted, all-in-one partner for laboratory technologies by consolidating their analytical infrastructure under a single provider.<br><br><i>“It’s nice to have a one-stop shop… which means that you work mostly with one major provider,” </i>says Dr. Ericsson.<br><br>Thermo Fisher Scientific has delivered leading technologies for the analysis of performance-enhancing drugs and other prohibited substances for more than a quarter century. In line with its commitment to advance the field, the technologies the company offers bolster the analytical arsenal of doping control laboratories, enabling them to provide multiple perspectives to enhance the reliability of results.<br><br>This strategic alignment not only reduces system fragmentation and compatibility issues but also enables rapid method implementation and consistent training across staff. Such standardization is key as doping tests grow more complex, involving both small molecules and peptide-based substances.</p><h3><strong>Looking ahead: The future of anti-doping analysis</strong></h3><p>As doping methods evolve, so must detection technologies. LADF continues to invest in instruments that deliver robustness, low maintenance, and ultra-sensitivity.<br><br><i>“It’s the sensitivity and the selectivity… and the possibility to increase the selectivity by doing, for instance, different MS/MS experiments,”</i> says Dr. Ericsson.<br><br>The industry trend supports this need. New approaches like stable isotope-labeled (SIL) internal standards, supercritical fluid chromatography (SFC), and top-down proteomics with Thermo Scientific Orbitrap instruments are being developed to quantify complex peptides and detect gene doping or biologics <sup>(1)</sup>.<br><br>In addition, growing concerns around unintentional doping—via contaminated supplements, food, or even environmental exposure—are pushing labs to adopt even higher sensitivity assays and more advanced data interpretation protocols <sup>(1)</sup>.<br><br>With a clear vision and cutting-edge technology, LADF is not only keeping pace with modern anti-doping demands but also setting a gold standard for scientific excellence in sport. Discover <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/forensics/antidoping.html">Thermo Fisher Scientific’s anti-doping solutions</a> and <a target="_blank" rel="noopener noreferrer" href="https://view.highspot.com/viewer/be96860291ab6345fc58cc95d9bc3156">watch Dr. Ericsson’s complete testimonial here.</a></p><h3><strong>Additional resources</strong></h3><ul><li>Video – <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=-8zRtsRkAcU">Mass Spectrometry Enables Top WADA Lab to Beat the Cheats: Athlete Doping Control</a></li><li>BBC Video – <a target="_blank" rel="noopener noreferrer" href="https://www.bbc.com/storyworks/connecting-the-dots/thermo-fisher">How can technology maintain sports integrity?</a></li><li>Testimonial – <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=mi1VHutyqPA">LCH Ludovic Bailly-Chouriberry Testimonial video for TSQ Altis Plus MS</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://assets.thermofisher.com/TFS-Assets/CMD/Technical-Notes/tn-000304-ms-testosterone-human-serum-faims-tn000304-en.pdf">TN000304 – Analysis of testosterone from human serum using FAIMS technology</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_001896_gc_ms_gc_ms_ms_tsq_9610_steroids_urine_tn001896_na_en_d1fd813050/tn-001896-gc-ms-gc-ms-ms-tsq-9610-steroids-urine-tn001896-na-en.pdf">TN001896 – Staying ahead of regulations for the analysis of steroids in urine with GC-MS/MS</a></li></ul><blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong>LinkedIn:</strong></a>&nbsp;#Antidoping, #LADF, #WADA, #SportsIntegrity</p></blockquote></div></article><section><blockquote><h4><strong>Ema Ruzic</strong></h4><p>Vertical Marketing Manager, Chromatography and Mass Spectrometry Division (CMD)</p></blockquote></section>

Inside Laboratoire Anti-Dopage Français (LADF): An Interview with Director Dr. Magnus Ericsson

<p><strong>In the week of September 1, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><h4><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 500 GC, LC, MS and spectroscopy webinars</strong>.</h4></blockquote><h5><strong>1. Thermo Fisher Scientific: Journey through time in Pesticides analysis</strong></h5><ul><li>Tu, 2.9.2025 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5434">Registration</a></li></ul><p>Learn how automation with TSQ 9610 GC-MS/MS boosts pesticide residue analysis. Explore QuEChERS, uSPE, PTV injection, and hydrogen carrier gas opportunities.</p><h5><strong>2. Thermo Fisher Scientific: The current landscape of MOSH/MOAH analysis</strong></h5><ul><li>Th, 4.9.2025 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5356">Registration</a></li></ul><p>Join us for a webinar about Mineral Oil Saturated Hydrocarbons (MOSH) and Mineral Oil Aromatic Hydrocarbons (MOAH) contamination in food, cosmetics, and packaging materials.</p>

Webinars LabRulezGCMS Week 36/2025

<p><strong>Efficient data handling is essential in chromatographic analysis, particularly in laboratories where high throughput and standardized reporting are required. The </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity Chromatography Software</strong></a><strong> offers a feature called </strong><i><strong>post-run settings</strong></i><strong>, which allows specific actions to be performed automatically after a measurement is completed. Among these actions, automatic report generation and printing play a crucial role in ensuring data traceability and immediate availability of results.</strong></p><p>This article provides a structured, step-by-step guide on how to configure Clarity to print reports—either to PDF or directly to a physical printer—immediately after the completion of a measurement sequence.</p><h3><strong>Understanding Post-Run Settings in Clarity</strong></h3><h4><strong>What Are Post-Run Settings?</strong></h4><p>Post-run settings are predefined actions executed automatically once a chromatographic run is finished. These can include exporting results, generating reports, sending notifications, or printing.</p><h4><strong>Location of Post-Run Settings</strong></h4><ul><li><strong>Single Analysis tab</strong>: Applies settings to individual chromatographic runs.</li><li><strong>Sequence window columns</strong>: Applies settings across multiple analyses in a batch sequence.</li></ul><p>For this guide, we focus on the <strong>Sequence window</strong> to automate printing.</p><h4><strong>Materials and Tools Required</strong></h4><ul><li><strong>Clarity Chromatography Software</strong> with post-run functionality enabled</li><li>Configured <strong>chromatogram window</strong> for visualization</li><li><strong>Overlay mode</strong> (optional, for multiple chromatograms)</li><li>Defined <strong>report style</strong> specifying the content and layout of the printed report</li><li>Access to a <strong>printer</strong> (physical or virtual PDF printer)</li></ul><h4><strong>Step-by-Step Procedure</strong></h4><h5><strong>1. Display Hidden Post-Run Columns</strong></h5><p>By default, most post-run settings such as <i>Print to PDF</i> remain hidden.</p><ul><li>Navigate to the <strong>Setup Columns</strong> dialog in the Sequence window.</li><li>Enable visibility for the <i>Print to PDF</i> (or <i>Print</i>) column.</li></ul><h5><strong>2. Prepare Chromatogram Window</strong></h5><p>To ensure all relevant chromatograms are included in a single report:</p><ol><li>Open the <strong>chromatogram window</strong>.</li><li>Confirm no chromatogram is currently active.</li><li>Activate <strong>Overlay Mode</strong>.<ul><li>When enabled, multiple chromatograms can be printed together.</li><li>If disabled, each chromatogram is printed separately.</li></ul></li></ol><h5><strong>3. Configure Sequence Actions</strong></h5><ul><li>In the <strong>Sequence window</strong>, check the <strong>Open</strong> checkbox for each chromatogram to be printed.</li><li>Select <strong>Print to PDF</strong> (or <strong>Print</strong>) on the final row.</li><li>Ensure the correct <strong>report style</strong> is applied in the row where the print action will execute.</li></ul><h5><strong>4. Define Report Style</strong></h5><p>The report style determines the exact content and structure of the printed report.</p><p><strong>a) Edit Report Style</strong></p><ul><li>Click the <strong>Edit Current Report Style</strong> icon from the chromatogram tab.</li><li>Adjust default settings:<ul><li>Change <strong>Signals</strong> to <i>All</i>.</li><li>Set <strong>Tiled By</strong> to <i>Chromatograms</i> (ensures each chromatogram has its own graph).</li></ul></li></ul><p><strong>b) Configure Results Tab</strong></p><ul><li>Switch to the <strong>Results</strong> tab in report style editor.</li><li>Adjust settings:<ul><li>Set <strong>Signals</strong> to <i>All</i>.</li><li>Enable <strong>Summary Table</strong>.</li><li>Check <strong>Word Wrap Long Text</strong> for improved readability.</li><li>Select <strong>Force Inverted</strong> in the <i>Table Layout</i> section (compact format with inverted rows and columns).</li></ul></li><li>Save the customized report style.</li></ul><h5><strong>5. Execute Measurement and Generate Report</strong></h5><ul><li>Start the measurement sequence.</li><li>Upon completion, Clarity automatically generates the configured report.</li><li>The final report will include:<ul><li><strong>Graphs of all chromatograms</strong> (each displayed separately).</li><li><strong>Individual result tables</strong> for each chromatogram.</li><li><strong>Summary table</strong> with wrapped names and inverted layout for compact readability.</li></ul></li></ul><h4><strong>Discussion and Best Practices</strong></h4><ul><li><strong>Overlay Mode</strong> is critical when multiple chromatograms must be combined in a single report. Without it, each run will print independently.</li><li><strong>Report styles</strong> should be tailored to laboratory needs. Including both graphical and tabular outputs ensures clear interpretation of results.</li><li><strong>PDF printing</strong> is recommended for digital archiving, while direct printing can be reserved for physical documentation requirements.</li><li>Periodic review of <strong>report templates</strong> ensures compliance with laboratory reporting standards and regulatory requirements.</li></ul><h4><strong>Conclusion</strong></h4><p>By configuring post-run settings in Clarity, laboratories can automate the generation and printing of chromatographic reports immediately after analysis. This approach streamlines workflows, reduces manual intervention, and ensures consistent documentation across all runs. Proper customization of report styles guarantees that results are presented clearly, whether for internal review, quality control, or regulatory reporting.</p>

How to print a report from Sequence in Clarity software

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 1st September 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you poster by <strong>Agilent Technologies / ASMS </strong>and application notes by <strong>EST Analytical</strong> and <strong>Shimadzu!</strong></p><h3><strong>1. Agilent Technologies / ASMS: Analysis of Phthalates Using GC/MS With Hydrogen Carrier Gas: The Importance of Reducing Interferences and Contamination&nbsp;</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ps_5977c_phthalates_hydrogen_gas_asms_2025_mp_359_en_agilent_d51f599179.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Due to the price of helium (He), many laboratories are looking for alternative carrier gases for their gas chromatography/mass spectrometry (GC/MS) methods. This work describes the evaluation of a single quadrupole GC/MS method for the analysis of 19 phthalates using hydrogen carrier gas and an EI source 1 . The method provides excellent peak shape, resolution, sensitivity, and a 13 min run time. Calibration curves were linear for 16 of the phthalates, with the remaining 3 alkoxy phthalates requiring a quadratic fit. Except for DINP and DIDP (mixtures of isomers), all compounds could be quantitated at low pg levels. Specific attention to the consumables used and their preparation before use is discussed and is important for reaching the lowest calibration levels.</p><h4><strong>Experimental</strong></h4><ul><li><strong>GC: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890+gc"><strong>Agilent 8890 GC</strong></a> with <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7693A"><strong>Agilent 7693A automatic liquid sampler</strong></a> and tray</li><li><strong>Column: </strong>Agilent HP-5MS UI 20 m x 0.18 mm id x 0.18 µm (p/n 19091S-577UI)</li><li><strong>MSD: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=5977C+GC%2FMSD"><strong>Agilent 5977C Inert Plus GC/MSD</strong></a></li></ul><h4><strong>Conclusions</strong></h4><ul><li>The Agilent 5977C GC/MSD and 8890 GC, when used with the method described here, provide excellent peak shape, resolution, sensitivity, and a 13 min run time..&nbsp;</li><li>The combination of hydrogen carrier and the Agilent J&amp;W HP-5ms 180 µm diameter column allowed for reduced analysis time relative to helium and a 250 µm diameter column .&nbsp;</li><li>Calibration curves were linear for 14 of the phthalates from 1 to 1,000 pg. DMEP and DBEP required quadratic curve fits, and DMEP and DEHP were calibrated from 2.5 to 1,000 pg. DINP and DIDP were calibrated from 50 to 20,000 pg with a linear fit.&nbsp;</li><li>Specific attention to the consumables used and their preparation before use is important for reaching the lowest calibration levels.</li></ul><h3><strong>2. EST Analytical: The Determination of Flavors in E-Liquids Using Purge and Trap Concentration</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Purge_and_Trap_E_Liquid_Compound_Sampling_Using_Purge_and_Trap_5c709b52f0.pdf"><strong>Full PDF for download</strong></a></li></ul><p>E-liquid can be composed of propylene glycol or vegetable glycerin alone or can be a combination of the two. Propylene glycol is less viscous and carries better flavor. It also acts as a preservative. However, it does produce less vapor and some people are allergic to it. Vegetable glycerin, on the other hand, is much denser, is super hypoallergenic and produces more vapor. The drawback to the vegetable glycerin is that it is not a preservative, so the vape liquid will not last as long. Both glycerin and propylene glycol readily dissolve in water, so preparing the samples to test by purge and trap was relatively easy. Conversely, as the E-liquid emitted a strong odor of the added flavors, only a small amount of the solution could be used for analysis. The volatile flavor components of the vape liquid were examined by dissolving the solution in water and sampling the water using purge and trap.</p><h4><strong>Experimental</strong></h4><p>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2160"><strong>Evolution purge and trap concentrator </strong></a>was configured with a Vocarb 3000 trap. The trap was conditioned at 260ºC for one hour. The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2159"><strong>Centurion WS syringe autosampler</strong></a> was set in water mode in order to run 5 ml samples. Next, samples were prepared using 10ul of vape solution dissolved in 100mls of de-ionized water. The parameters for the autosampler/purge and trap concentrator and the Gas Chromatograph/Mass Spectrometer (GC/MS) are outlined in Tables 1 and 2.</p><h4><strong>Conclusions</strong></h4><p>Since vape solution readily dissolves into water, purge and trap sampling proved to be an excellent technique for the determination of the volatile compounds in the E-liquids. Purge and trap sampling is an exhaustive sampling technique, so the results were very reproducible and provided the sensitivity to determine the lower level compounds in the solution. Furthermore, it was found that nicotine addition to the solution has an effect some of the compounds in the solution. So, the taste of the vape liquid is affected by the amount nicotine in the mix.</p><h3><strong>3. Shimadzu: Determination of Nitrobenzene Compounds in Nifedipine by GCMS&nbsp;</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_03_gcms_589_en_23eda751e7.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>User Benefits</strong></h4><ul><li>The direct dissolution protocol without pre-treatment, significantly enhancing analytical efficiency.</li><li>The specificity of the method is ensured by monitoring the characteristic ions of nitrobenzene compounds in selected ion monitoring (SIM) mode, which provides robust resistance to interferences.</li></ul><p>Nifedipine, a dihydropyridine calcium channel blocker with vasodilatory properties, is primarily indicated for the clinical management of hypertension and angina pectoris. Its synthetic route commences with 2-nitrotoluene as the starting material. Notably, the intermediate 2-nitrobenzyl alcohol, the byproduct 2- nitrobenzyl bromide, the reaction product 2-nitrobenzaldehyde, and potential impurities (3-nitrobenzaldehyde and 4- nitrobenzaldehyde) all contain nitrobenzene moieties, rendering them candidatesfor monitoring as potential genotoxic impurities. Previous studies have demonstrated that 2-nitrobenzaldehyde and 4-nitrobenzaldehyde exhibit mutagenicity in the Ames test, while 2-nitrotoluene has shown carcinogenicity in animal experiments. In accordance with the toxicological concern threshold (TTC) control approach specified in ICH M7, a threshold of 1.5 μg/day is recommended for genotoxic impurities in pharmaceuticals intended for lifelong administration. In this study, a method for the determination of six genotoxic impurities in nifedipine was developed using a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-QP2050"><strong>Shimadzu GCMSQP2050</strong></a> gas chromatography mass spectrometry. This method features simplified sample preparation, high sensitivity, and favorable repeatability, thereby enabling effective monitoring of the six nitrobenzene compounds as genotoxic impurities in nifedipine pharmaceutical.</p><h4><strong>Analytical Conditions</strong></h4><p>The analytical conditions are shown in Table1. <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-QP2050"><strong>GCMS-QP2050</strong></a> system was used for this Application News.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>A GC-MS method was established for the quantification of six nitrobenzene genotoxic impurities in nifedipine pharmaceuticals using a Shimadzu GCMS-QP2050 system. The calibration curves showed excellent linearity within the concentration range of 20-200 μg/L, with correlation coefficients (R&gt;0.999). Precision was evaluated through six replicate injections of the 50 μg/L standard solution, and the relative standard deviations (RSDs) of peak areas for all analytes were less than 4%. Spike recovery experiments were performed at three concentration levels (0.005, 0.01, and 0.032 μg/g) in actual matrices, resulting in recovery rates ranging from 95.85% to 117.64%. This method is characterized by simplified sample preparation, high sensitivity (IDLs of 0.263-0.496 μg/L), and good repeatability. Overall, it provides a validated analytical strategy for quality control monitoring of the target genotoxic impurities.</p>

News from LabRulezGCMS Library - Week 36, 2025

<p><strong>For most reversed-phase SPE applications using a silica-based SPE media (e.g. those using </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1507"><strong>Strata™ C18-E</strong></a><strong>), cartridges (or wells in the case of 96-well plates) are initially conditioned using an organic solvent such as methanol, followed by rinsing with water or a buffer. If silica-based SPE media is allowed to dry out for extended periods of time during these conditioning steps, they may exhibit poor retention for target analytes, especially if the target compounds are polar in nature. It is therefore essential that SPE users pay close attention to their methods during this crucial conditioning step in order to obtain accurate and reproducible results.&nbsp;</strong></p><p>The figure below shows two <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1546"><strong>Strata C18-T </strong></a>cartridges (1 gm/6 mL) that were loaded with 4 mL of a blue dye (CuCl2). The cartridge on the left (A) was first conditioned using 12 mL of methanol, then was dried for ten minutes under high vacuum (10” of Hg), followed by 12 mL of water. As you can see from the figure, the blue dye is found uniformly distributed throughout the sorbent bed. In contrast, the cartridge on the right hand side (B) was conditioned with methanol, followed immediately by water without any drying. Under these conditions, the blue dye is visible as a tight, focused band at the head of the sorbent bed. After elution, recovery from cartridge B was far greater than was the recovery from cartridge A (the dried cartridge). This difference in recovery can be attributed primarily to the poor retention of the dye compound due to drying of the sorbent bed.&nbsp;</p><h3><strong>Tips to Prevent Accidental over-drying to prevent loss of Analyte</strong></h3><ul><li>Don’t allow your bed to dry out at any step (unless it is specifically indicated in the method).</li><li>Use gravity flow as an alternative to vacuum to prevent over-drying.</li><li>Centrifuge at low velocities (e.g. 500 RPM) or use positive pressure.</li><li>Switch to an equivalent polymeric sorbent, such as Strata-X, which do not display shifts in retention and recovery due to periodic drying</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Over_Drying_of_Silica_Based_SPE_Cartridges_Can_Lead_to_Poor_Sample_Recovery_0839e0ef05.jpg" alt="Phenomenex: Over-Drying of Silica-Based SPE Cartridges Can Lead to Poor Sample Recovery: A. Silica C18 sorbent dried after conditioning with methanol; B. Silica C18 sorbent conditioned without drying." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Over_Drying_of_Silica_Based_SPE_Cartridges_Can_Lead_to_Poor_Sample_Recovery_0839e0ef05.jpg 245w," sizes="100vw" width="548" height="312"></p>

Over-Drying of Silica-Based SPE Cartridges Can Lead to Poor Sample Recovery

<h4><strong>What is a laboratory nitrogen generator and when is one used?</strong></h4><p>A laboratory nitrogen generator is a machine that is able to separate nitrogen molecules from the air around it by using a compressed air source. By removing the vast majority of oxygen molecules and other impurities from an air source, these machines are able to produce high purity or ultra-high purity nitrogen gas needed to run a variety of different laboratory applications and instruments.</p><p>There are many <strong>applications that require a lab to use a nitrogen gas generator</strong>, with LC-MS, GC, ICP, ELSD, and sample preparation/blowdown evaporation being the most common. Each application will have specific nitrogen requirements (flow rate, purity level, etc.) which will determine the exact type of N2 generator needed by the lab.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_Gas_Flow_and_Purity_Requirements_by_Application_e018a3a5df.jpg" alt="Organomation: Gas Flow and Purity Requirements by Application" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_Gas_Flow_and_Purity_Requirements_by_Application_e018a3a5df.jpg 245w," sizes="100vw" width="1167" height="461"></p><p>N2 gas generators aren’t the only way labs are able to obtain nitrogen. Let’s get into some other common sources, and discuss when they may be a better fit.</p><h4><strong>Common ways labs obtain nitrogen</strong></h4><p>Although nitrogen generators are a must-have for many laboratories, there are some instances where they just don’t make sense. Some labs may have a nitrogen consumption rate that is just too high for a generator to meet. On the other hand, some may require such a low amount of gas that the purchase of a generator can’t be justified.</p><h4><strong>So what are the common nitrogen gas sources for labs and who should be using each?</strong></h4><h5><strong>1. Nitrogen Tanks, Cylinders, or Dewars</strong></h5><p>Ordering nitrogen gas from a third party vendor and having it delivered to your facility in tanks, cylinders, or Dewars is a great option for labs who have a very low or sporadic need for nitrogen. It’s a convenient way to get a small amount of N2 gas which may only be needed for a single project, without committing to the purchase of a new piece of equipment.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_nitrogen_7_cb5c6ba92d.jpg" alt="Organomation: Nitrogen Tanks, Cylinders, or Dewars" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_nitrogen_7_cb5c6ba92d.jpg 234w," sizes="100vw" width="438" height="292"></p><h5><strong>2. Built-In Nitrogen Source</strong></h5><p>Some large analytical or manufacturing companies have full nitrogen systems installed directly in their building which are able to supply gas to an entire lab or labs, depending on the size. This allows lab techs to have a constant supply of N2 gas piped directly to their fume hood or workstation. Due to the cost and space requirements, this is only a worthwhile investment for large laboratories with very high nitrogen consumption requirements.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_nitrogen_6_07dce4d97c.jpg" alt="Organomation: Built-In Nitrogen Source" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_nitrogen_6_07dce4d97c.jpg 229w," sizes="100vw" width="450" height="306"></p><h5><strong>3. Nitrogen Generator</strong></h5><p>Investing in a nitrogen gas generator is an ideal choice for labs who fall in the middle of options 1 and 2. If your application requires N2 on a regular basis, but doesn’t necessitate a building-wide gas source, a generator is the perfect accommodation. Most are completely plug-and-play, meaning once it’s set up, you can simply turn it on or off as needed, without any reconfiguration.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_nitrogen_5_70f9f8c6ac.jpg" alt="Organomation: Nitrogen Generator" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_nitrogen_5_70f9f8c6ac.jpg 231w," sizes="100vw" width="460" height="311"></p><h4><strong>Which nitrogen generator technology is right for me?</strong></h4><p>There are two common types of N2 generators, differentiated by the way they separate nitrogen molecules from the air. There are membrane-based generators and PSA generators.</p><h5><strong>1. Membrane-Based</strong></h5><p>The technology behind membrane-based nitrogen generators is…you guessed it…a membrane. This type of generator contains a series of <strong>narrow, semi-permeable fibers located in a porous membrane</strong>. As compressed air is passed through, some gas molecules such as oxygen, carbon dioxide and water vapor are able to permeate the fibers quite easily and are vented off, while nitrogen molecules pass through much slower. This results in a <strong>high purity nitrogen stream (95-99% purity) </strong>from the membrane outlet.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_nitrogen_4_015d9a533e.jpg" alt="Organomation: NITRO-GEN" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_nitrogen_4_015d9a533e.jpg 98w," sizes="100vw" width="221" height="351"></p><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1902"><strong>Organomation’s NITRO-GEN</strong></a> is a popular membrane-based N2 generator for sample preparation that is used by analytical laboratories worldwide. Producing <strong>up to 20 L/min at up to 99% purity</strong>, this lightweight generator is suitable for those using blowdown evaporation for solvent concentration. Find out how the NITRO-GEN supplies high purity nitrogen for a sample concentrator.</p><h5><strong>2. PSA (Pressure Swing Adsorption) Technology</strong></h5><p><strong>PSA generators </strong>work by using two columns of tightly packed material called Carbon Molecular Sieve (CMS). Compressed air will pass through one CMS column, which will adsorb all oxygen, water vapor and other molecules, while allowing nitrogen to pass through and be stored in an accumulation tank. Once one sieve becomes saturated, compressed air will be diverted to the second CMS column, allowing the first one to depressurize, releasing all adsorbed impurities through an outlet. This process repeats over and over, leaving behind N2 gas with a <strong>98-99.999% purity.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_nitrogen_3_2cea8f24ba.jpg" alt="Organomation: NITRO-GEN+ " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_nitrogen_3_2cea8f24ba.jpg 156w," sizes="100vw" width="600" height="600"></p><p>As this technology tends to produce a slightly higher purity and flow rate than with membranes, PSA generators are a great choice for both <strong>sample preparation and LC-MS applications</strong>. The <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1901"><strong>NITRO-GEN+</strong></a> is an affordable PSA generation solution that is able to produce <strong>up to 35 L/min</strong>, meeting all your sample prep and analytical needs. Find out how the NITRO-GEN+ can be your laboratory’s all-in-one nitrogen generation solution.</p><h4><strong>The true cost of tank-based nitrogen solutions</strong></h4><p>Although seen as the popular and “traditional” nitrogen generation solution by many, the process of purchasing N2 tanks is quite pricey, especially for those consuming gas on a weekly or daily basis. There are many associated costs with tank-based solutions including the cost of the actual nitrogen, tank rentals, and required delivery. Let’s take a look at how much one analytical lab could be spending on tanks in just one year.</p><blockquote><p><strong>** This example uses estimated pricing. Your actual costs may vary.</strong></p></blockquote><p>A <strong>typical nitrogen tank costs around $50</strong>. It’s also common for vendors to charge a monthly rental fee, which is often around $20 each month, per <strong>individual cylinder</strong>. On top of that, you’ll be charged for delivery – for this example, let’s say the lab orders their tanks locally and it only costs them $25 per delivery.</p><p>Now, let’s estimate the nitrogen consumption for this particular lab. Let’s say they need 30 L/min of nitrogen for 4 hours a day, 5 days a week. That equals 36,000 liters of nitrogen per week, or about 5 cylinders. Over the course of a whole year, that’s nearing 2 million liters and over 250 nitrogen cylinders.</p><p>In just one year, this lab would be spending over $18,000 in nitrogen tanks alone! For most, this just isn’t feasible.</p><h4><strong>Is it cheaper to generate my own nitrogen?</strong></h4><p>Acquiring a generator and producing your own nitrogen is a sure way to cut back on these extensive costs. Laboratory generators that are able to produce moderate flow rates and purity levels can range anywhere from $5,000 to $40,000. This one-time payment plus any required maintenance are the only things you have to take care of. No more worrying about rental costs, delivery costs, or wondering why the price of tanks has suddenly increased.</p><p>Depending on a lab’s nitrogen consumption levels, the payback period on a N2 generator could be as little as 1-3 years.</p><p>Determine how long it would take your lab to pay off a generator by using this simple <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/would-a-nitrogen-generator-make-sample-preparation-more-affordable"><strong>nitrogen generator payback period calculator,</strong></a> and see how much you could be saving.</p><h4><strong>All the headaches you can save by adding on-site nitrogen generation</strong></h4><p>Now that you’ve seen how much money a generator can save you compared to tanks, let’s dive deeper into all the headaches nitrogen generators can save you to determine if generating nitrogen in your lab is worthwhile.</p><h5><strong>1. No need to purchase, store, or handle nitrogen cylinders</strong></h5><p>Not only are tank-based nitrogen solutions expensive, they are also quite time-consuming and labor-intensive. Having to dedicate a closet or a corner of the lab to store extra tanks or remembering to order more when you’re running low are just minor inconveniences. Not to mention, high-pressure tanks can be a danger to those handling them.</p><h5><strong>2. Never run out of nitrogen again</strong></h5><p>With tanks, you always have to make sure you have enough for the day or week ahead. Running out of nitrogen unexpectedly can cause major hiccups in your workflow, and can even ruin the analysis/test you’re currently working on. With a nitrogen generator, you’ll always have a steady stream of high purity nitrogen available when you need it.</p><h5><strong>3. Never pause your operation to replace N2 tanks</strong></h5><p>Let’s say you’re in the middle of concentrating down some analytical samples using a nitrogen dryer, and your nitrogen tank has just run out. You’re forced to stop the evaporation process, disconnect the empty tank, move it aside, bring in a new tank, recalibrate it, and hook it up to the evaporator. All the while your samples are sitting in the open air with the risk of oxidizing or otherwise becoming contaminated. With the constant gas supply a N2 generator provides, you’ll never have to worry about this happening.</p><h5><strong>4. Reduce waste and be more eco-friendly</strong></h5><p>Utilizing a laboratory generator can help <strong>reduce your carbon footprint </strong>by eliminating the need to participate in tank exchanges and having nitrogen cylinders shipped to and from your laboratory. Since you’re generating nitrogen from the air around you, you’ll never require a refill or replacement.</p><h4><strong>Why nitrogen is ideal for drying samples</strong></h4><p>Labs using nitrogen blowdown evaporation, a common sample preparation step before analysis, are major drivers of the nitrogen generation market. Have you ever wondered why nitrogen is used to dry down excess solvent? It’s actually quite simple.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_nitrogen_2_6c56104216.jpg" alt="Organomation: nitrogen is ideal for drying samples" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_nitrogen_2_6c56104216.jpg 236w," sizes="100vw" width="866" height="572"></p><h5><strong>1. It has the fastest evaporation rate.</strong></h5><p>Studies have proven that nitrogen gas yields the fastest evaporation rates compared to other inert gasses. Evaporation rate is dependent on the humidity of the atmosphere. So what’s the most effective way to reduce humidity levels? – by purging the atmosphere with nitrogen, aka nitrogen blowdown evaporation.</p><h5><strong>2. It poses minimal risks to samples &amp; lab techs.</strong></h5><p>Dry nitrogen is considered an inert gas, meaning it is chemically inactive. Unlike compressed air that contains high levels of oxygen and other impurities, dry nitrogen will not deteriorate your samples in any way during the evaporation process. N2 is also non-flammable, meaning it will not increase the risk of a chemical combustion, which is especially important when working with other flammable or reactive solvents.</p><h5><strong>3. It's affordable.</strong></h5><p>Nitrogen gas is far more affordable than other inert gasses such as helium or argon. And as you’ve learned thus far, this is especially true when using a nitrogen generator which can provide an endless supply of high purity N2.</p><h4><strong>Installing a nitrogen generation system for sample preparation</strong></h4><p>Nitrogen generators have been used and trusted for sample concentration for years, specifically in conjunction with the <strong>TurboVap, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?manufacturerItems=540&amp;search=N-EVAP"><strong>N-EVAP,</strong></a><strong> and RapidVap</strong>. Once you've narrowed down your options, it's important to also take a look at the key considerations for installing a generator in your lab.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_nitrogen_e00163c1b6.jpg" alt="Organomation: Baylor University - Robbins College of Health and Human Services Supplying multiple nitrogen dryers with one generator" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_nitrogen_e00163c1b6.jpg 209w," sizes="100vw" width="2000" height="1500"></p><p>To conclude, let's take a look at some real-life examples of laboratories who have integrated a nitrogen generator into their sample preparation workflow to see just how impactful it can be.</p><blockquote><p>If you have any questions or would like assistance with your nitrogen generator journey, please reach out to <strong>sales@organomation.com</strong> or call our team at <strong>978-838-7300</strong>.</p></blockquote>

Nitrogen Generators for Sample Preparation: Everything You Need To Know

<p><strong>This article provides a structured explanation of how to create and manage a measurement sequence in </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity Chromatography Data System</strong></a><strong> (CDS). It is based on the instructional video “</strong><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=FWaakYQ2ED8"><strong>How to Prepare a Sequence</strong></a><strong>” and reformatted into a comprehensive technical article.</strong></p><h3><strong>Introduction</strong></h3><p>In chromatography workflows, <strong>sequences</strong> are used to define a set of analytical runs in a structured, automated manner. By carefully preparing a sequence, users can save time, reduce errors, and ensure consistency across multiple injections and vials.</p><p><strong>This guide covers:</strong></p><ul><li>Creating a new sequence in Clarity</li><li>Filling and managing sequence rows</li><li>Configuring multiple injections and vial ranges</li><li>Assigning sample types and calibration levels</li><li>Using fill functions to accelerate sequence preparation</li><li>Saving the sequence for measurement</li></ul><h3><strong>Tools and Software</strong></h3><ul><li><strong>Clarity CDS software</strong> with the sequence editor</li><li>Access to appropriate <strong>methods and sample lists</strong> prepared in advance</li><li>Knowledge of vial numbering and sample IDs for the autosampler</li></ul><h3><strong>Step-by-Step Procedure</strong></h3><h4><strong>1. Creating a New Sequence</strong></h4><ol><li>Open the <strong>Sequence window</strong> in Clarity.</li><li>Click <strong>New</strong> to create a fresh sequence table.</li><li>In the first row, enter the required details, such as:<ul><li><strong>Method name</strong></li><li><strong>Sample name</strong></li><li><strong>File name format</strong> (e.g., change variable from <i>Sample ID</i> to <i>Sample</i>)</li></ul></li></ol><blockquote><p>⚠️ <i>Tip:</i> Values from the first row are automatically copied to new rows, ensuring consistency.</p></blockquote><h4><strong>2. Defining Sequence Rows</strong></h4><ul><li>Check the <strong>Run</strong> box to activate the first row.</li><li>Add as many rows as your application requires.</li><li>In the example case:<ul><li>A total of <strong>four rows</strong> were defined.</li><li>Rows can represent repeated injections from one vial or samples across multiple vials.</li></ul></li></ul><h4><strong>3. Configuring Multiple Injections and Vial Ranges</strong></h4><ul><li><strong>Multiple injections from one vial</strong>:<ul><li>Example: Row 1 → set <strong>Number of injections per vial</strong> = 2.</li></ul></li><li><strong>Defining vial ranges</strong>:<ul><li>Example: Row 4 → set <strong>End vial number</strong> = 7 to cover vials 4 through 7.</li></ul></li></ul><h4><strong>4. Assigning Sample Types and Calibration Levels</strong></h4><ol><li>Mark the <strong>Sample type</strong> for each row.<ul><li>Example: The first three rows are defined as <strong>Standards</strong>.</li></ul></li><li>Assign <strong>Calibration levels</strong>:<ul><li>Enter <i>Level 1</i> in the first row.</li><li>Select the corresponding cells for rows 1–3.</li><li>Use <strong>Fill Series</strong> from the right-click menu to automatically increment levels (1, 2, 3).</li></ul></li></ol><h4><strong>5. Using Fill Down and Fill Series Functions</strong></h4><p>To speed up sequence preparation, Clarity provides convenient functions:</p><ul><li><strong>Fill Down</strong>: Copies a selected cell’s value into the rows below.</li><li><strong>Fill Series</strong>: Automatically generates incremental values across selected cells.</li></ul><p>Example applications:</p><ul><li>Fill down method names, injection volumes, or vial numbers.</li><li>Fill series for calibration levels or sequence numbering.</li></ul><h4><strong>6. Saving the Sequence</strong></h4><p>Once all parameters are set:</p><ol><li>Click <strong>Save</strong>.</li><li>Assign a descriptive sequence name for future reference.</li><li>The sequence is now fully prepared and ready for measurement.</li></ol><h3><strong>Discussion and Best Practices</strong></h3><ul><li><strong>Consistency:</strong> Use “Fill Down” to avoid manual repetition and reduce errors.</li><li><strong>Calibration:</strong> Always double-check calibration levels when working with standards.</li><li><strong>Efficiency:</strong> Plan vial positions and injection counts before building the sequence.</li><li><strong>File Management:</strong> Define a logical file naming convention early to maintain clarity in data processing.</li></ul><h3><strong>Conclusion</strong></h3><p>By following this structured approach in Clarity CDS, laboratory staff can efficiently prepare sequences for chromatography runs. The combination of sequence rows, vial configuration, and automated fill functions ensures faster setup, minimized manual errors, and improved consistency across analytical measurements.</p><p>With a properly saved sequence, the system is fully ready for automated data acquisition and subsequent analysis.</p>

How to create a sequence in Clarity software

<p><strong>Gas chromatography coupled with mass spectrometry (GC/MS) is one of the most widely used analytical techniques for the separation, identification, and quantification of volatile and semi-volatile compounds. At the heart of most benchtop GC/MS systems lies the single quadrupole (SQ) mass detector, also known as a mass selective detector (MSD).</strong></p><h4><strong>What is a Single Quadrupole Detector?</strong></h4><p>A quadrupole mass spectrometer consists of four precisely aligned metal rods that create oscillating electric fields. Ions generated in the ion source are filtered by the quadrupole depending on their mass-to-charge ratio (m/z). Only ions of a selected m/z value reach the detector at any given time, enabling selective ion monitoring (SIM) as well as full scan acquisition.</p><h4><strong>Main Components of a SQ GC/MSD</strong></h4><ul><li><strong>Ion Source</strong> – commonly electron ionization (EI) or chemical ionization (CI), where analyte molecules are ionized.</li><li><strong>Quadrupole Mass Filter</strong> – four rods generating alternating RF/DC voltages, allowing passage of ions with a specific m/z.</li><li><strong>Detector</strong> – typically an electron multiplier that amplifies ion signals into measurable currents.</li><li><strong>Vacuum System</strong> – turbomolecular and roughing pumps that maintain high vacuum for ion transmission.</li><li><strong>Electronics &amp; Control</strong> – power supplies, RF/DC generators, and data system software.</li></ul><h4><strong>Advantages of Single Quadrupole Detectors</strong></h4><ul><li><strong>Robustness and reliability</strong> – decades of proven performance in routine laboratories.</li><li><strong>High sensitivity</strong> – suitable for trace analysis in complex matrices.</li><li><strong>Versatility</strong> – applicable across environmental, food safety, pharmaceutical, petrochemical, and forensic fields.</li><li><strong>Ease of use</strong> – streamlined hardware design with wide support for software and service.</li><li><strong>Cost efficiency</strong> – more affordable compared to high-resolution or tandem mass spectrometry systems.</li></ul><h4><strong>Typical Applications</strong></h4><ul><li>Environmental analysis (e.g., VOCs, pesticides, dioxins)</li><li>Food safety (residues, contaminants, flavors)</li><li>Pharmaceutical QC and impurity profiling</li><li>Petrochemical characterization</li><li>Forensic and toxicological investigations</li></ul><h3><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=19"><strong>Available Bazaar Systems and Accessories</strong></a></h3><h5><strong>1. Agilent 5977 GC/MS System (Refurbished)</strong></h5><p>Reliable, versatile GC/MS system designed for environmental, food, chemical, petrochemical, and forensic applications. Combines advanced GC and MS technologies for high sensitivity.</p><ul><li><strong>Price: </strong>on request</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/83">Detailed offer can be found here</a></li></ul><h5><strong>2. Agilent 5975 (G3171A) Mass Spectrometer (Refurbished)</strong></h5><p>Robust GC/MSD with high precision and reliability, widely used in environmental, food safety, pharma, and forensic labs.</p><ul><li><strong>Price:</strong> on request</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/82">Detailed offer can be found here</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_Agilent_5975_B_MS_05a462cc81.jpg" alt="LabRulez : Agilent 5975 (G3171A) Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_Agilent_5975_B_MS_05a462cc81.jpg 107w," sizes="100vw" width="940" height="1373"></p><h5><strong>3. Agilent 5973 GC/MS System (Refurbished)</strong></h5><p>Versatile system offering sensitivity, reliability, and flexibility for a wide application range.</p><ul><li><strong>Price:</strong> on request</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/81">Detailed offer can be found here</a></li></ul><h5><strong>4. Agilent 5977B HES Analyzer, G7077-67797 (Tested)</strong></h5><p>Replacement analyzer assembly with <strong>High-Efficiency Source (HES)</strong> for Agilent 5977B GC/MSD. Increases sensitivity for trace analysis.</p><ul><li><strong>Price: </strong>€6,875.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/478">Detailed offer can be found here</a></li><li>Two pieces available - <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/461">details of the second item can be found here</a></li></ul><h5><strong>5. Agilent 5977 EI Extraction Analyzer, G7077-69201 (Tested)</strong></h5><p>Analyzer assembly designed for electron ionization (EI) in Agilent 5977 systems.</p><ul><li><strong>Price:</strong> €6,875.00</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/462">Detailed offer can be found here</a></li></ul><h5><strong>6. Agilent Electron Ionization (EI) Extraction Source Assembly, G3870-67720 (New)</strong></h5><p>EI source assembly for Agilent 5977 and 7000 series GC/MS systems.</p><ul><li><strong>Price: </strong>on request</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/331">Detailed offer can be found here</a></li></ul><h5><strong>7. Agilent 7890A/5975C GC/MSD (G3440A/G3174A) (Refurbished)</strong></h5><p>Configured system with 7890A GC and 5975C MSD plus GC PAL autosampler.</p><ul><li><strong>Price: </strong>on request</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/261">Detailed offer can be found here</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_Agilent_7890_A_5975_C_GC_MSD_G3440_A_G3174_A_Refurbished_4239620b6b.jpg" alt="LabRulez: Agilent 7890A/5975C GC/MSD (G3440A/G3174A)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_Agilent_7890_A_5975_C_GC_MSD_G3440_A_G3174_A_Refurbished_4239620b6b.jpg 175w," sizes="100vw" width="1247" height="1112"></p><h5><strong>8. Agilent 6890N/5973N GC/MSD System (SSL, PTV, FID) (Refurbished)</strong></h5><p>Advanced GC/MSD system with multiple inlets (SSL, PTV), detectors (FID, MSD). Designed for complex matrices in environmental, pharma, and petrochemical labs.</p><ul><li><strong>Price:</strong> on request</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/257">Detailed offer can be found here</a></li></ul><h5><strong>9. Agilent GC/MSD (6850/5975B) Purge and Trap System (Refurbished)</strong></h5><p>Special configuration of 6850 GC and 5975B MSD with purge and trap for volatile organic compound analysis.</p><ul><li><strong>Price: </strong>on request</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/235">Detailed offer can be found here</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_Agilent_6850_5975_B_Purge_and_Trap_GCMSD_system_6903543f4c.jpg" alt="LabRulez: Agilent GC/MSD (6850/5975B) Purge and Trap System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_Agilent_6850_5975_B_Purge_and_Trap_GCMSD_system_6903543f4c.jpg 216w," sizes="100vw" width="1428" height="1035"></p>

Single Quadrupole Mass Detectors (SQ) in GC/MS

<p><strong>From September until the end of 2025, the global GC/MS community can look forward to a diverse program of conferences, scientific schools, and training courses. These events are a great opportunity to discover new trends, learn advanced methods, and network with peers from around the world. Whether you are interested in fundamental research, applied solutions, or software training, there is plenty to choose from in the upcoming months.</strong></p><h5><strong>Shimadzu at 10th Lipidomics Forum</strong></h5><ul><li>14–17 September 2025 | Vienna, Austria</li><li><strong>Organizer:</strong> Shimadzu Corporation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/907">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_at_10th_Lipidomics_Forum_aae43f6640.jpg" alt="Shimadzu: Shimadzu at 10th Lipidomics Forum" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_at_10th_Lipidomics_Forum_aae43f6640.jpg 245w," sizes="100vw" width="1390" height="390"></p><h5><strong>10th Lipidomics Forum</strong></h5><ul><li>14–17 September 2025 | Vienna, Austria</li><li><strong>Organizer: </strong>University of Vienna</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/896">More information and registration at this link</a></li></ul><h5><strong>14th International Conference on Instrumental Methods of Analysis (IMA-2025)</strong></h5><ul><li>14–17 September 2025 | Kefalonia, Greece</li><li><strong>Organizer:</strong> National Technical University of Athens</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/795">More information and registration at this link</a></li></ul><h5><strong>53rd Conference on Synthesis and Analysis of Drugs 2025</strong></h5><ul><li>17–19 September 2025 | Kurdějov, Czech Republic</li><li><strong>Organizer: </strong>Masaryk University</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/678">More information and registration at this link</a></li></ul><h5><strong>21th ISC ‘Modern Analytical Chemistry’</strong></h5><ul><li>18–19 September 2025 | Prague, Czech Republic</li><li><strong>Organizer: </strong>European Chemical Society (EuChemS)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/839">More information and registration at this link</a></li></ul><h5><strong>MSACL 2025 – 15th Annual Conference &amp; Exhibits</strong></h5><ul><li>21–26 September 2025 | Montréal, Canada</li><li><strong>Organizer:</strong> MSACL</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/731">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MSACL_2025_cover_image_762faaf59f.jpg" alt="MSACL: MSACL 2025" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MSACL_2025_cover_image_762faaf59f.jpg 245w," sizes="100vw" width="1920" height="1080"></p><h5><strong>7th International Mass Spectrometry School (IMSS) 2025</strong></h5><ul><li>21–26 September 2025 | Vorau, Styria, Austria</li><li><strong>Organizer:</strong> International Mass Spectrometry Foundation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/906">More information and registration at this link</a></li></ul><h5><strong>Mass Spectrometry Symposium 2025</strong></h5><ul><li>23–26 September 2025 | Costa Mesa, CA, USA</li><li><strong>Organizer: </strong>Local MS societies (CASSS)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/897">More information and registration at this link</a></li></ul><h5><strong>ISSS 2025 – 29th International Symposium on Separation Sciences</strong></h5><ul><li>25–27 September 2025 | Belgrade, Serbia</li><li><strong>Organizer:</strong> International Symposium on Separation Sciences (ISSS)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/730">More information and registration at this link</a></li></ul><h5><strong>GDCh Science Forum Chemistry 2025</strong></h5><ul><li>29 September – 1 October 2025 | Karlsruhe, Germany</li><li><strong>Organizer:</strong> Gesellschaft Deutscher Chemiker (GDCh)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/755">More information and registration at this link</a></li></ul><h5><strong>International Symposium on Preparative and Process Chromatography (PREP) 2025</strong></h5><ul><li>29 September – 2 October 2025 | Philadelphia, PA, USA</li><li><strong>Organizer: </strong>LD Organisation srl</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/899">More information and registration at this link</a></li></ul><h5><strong>21st Raman Imaging Symposium</strong></h5><ul><li>29 September – 1 October 2025 | Ulm, Germany</li><li><strong>Organizer: </strong>Oxford Instruments</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/898">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/21st_Raman_Imaging_Symposium_13c3033654.jpg" alt="Oxford: 21st Raman Imaging Symposium" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_21st_Raman_Imaging_Symposium_13c3033654.jpg 245w," sizes="100vw" width="1200" height="627"></p><h5><strong>SciX 2025</strong></h5><ul><li>5–10 October 2025 | Covington, KY, USA</li><li><strong>Organizer</strong>: The Federation of Analytical Chemistry and Spectroscopy Societies (FACSS)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/796">More information and registration at this link</a></li></ul><h5><strong>ASMS – 39th Asilomar Conference on Mass Spectrometry</strong></h5><ul><li>10–15 October 2025 | Monterey, CA, USA</li><li><strong>Organizer: </strong>ASMS</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/747">More information and registration at this link</a></li></ul><h5><strong>Gulf Coast Conference (GCC) 2025</strong></h5><ul><li>14–15 October 2025 | Galveston, Texas, USA</li><li><strong>Organizer: </strong>Gulf Coast Conference</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/905">More information and registration at this link</a></li></ul><h5><strong>Live from the Lab: Solutions for Environmental and Food Contaminant Testing</strong></h5><ul><li>16–23 October 2025 | Europe / North America / Online</li><li><strong>Organizer:</strong> Thermo Fisher Scientific</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/920">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Live_from_the_Lab_Solutions_for_Omics_Research_9cbb774bb0.jpg" alt="Thermo Fisher Scientific: Live from the Lab - Solutions for environmental and food contaminant testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Live_from_the_Lab_Solutions_for_Omics_Research_9cbb774bb0.jpg 245w," sizes="100vw" width="1541" height="686"></p><h5><strong>SOFT 2025</strong></h5><ul><li>26–31 October 2025 | Portland, OR, USA</li><li><strong>Organizer: </strong>Society of Forensic Toxicologists</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/767">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/SOFT_2025_1c3812bfee.jpg" alt="Society of Forensic Toxicologists Inc.: SOFT 2025" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_SOFT_2025_1c3812bfee.jpg 245w," sizes="100vw" width="1360" height="747"></p><h5><strong>ASMS – 36th Fall Workshop</strong></h5><ul><li>3–4 November 2025 | Seattle, WA, USA</li><li><strong>Organizer</strong>: ASMS</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/746">More information and registration at this link</a></li></ul><h5><strong>The International Doctoral Conference on Advances in Chemistry (IDCAC 2025)</strong></h5><ul><li>7–8 November 2025 | University of Chemistry and Technology, Prague</li><li><strong>Organizer: </strong>UCT Prague</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/911">More information and registration at this link</a></li></ul><h5><strong>AAPS 2025 PHARMSCI 360</strong></h5><ul><li>9–12 November 2025 | San Antonio, TX, USA</li><li><strong>Organizer: </strong>AAPS</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/753">More information and registration at this link</a></li></ul><h5><strong>24th Human Proteome Organization World Congress (HUPO) 2025</strong></h5><ul><li>9–13 November 2025 | Toronto, Canada</li><li><strong>Organizer: </strong>HUPO</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/732">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/HUPO_2025_24th_Human_Proteome_Organization_World_Congress_cover_image_jpg_1256bb4d21.jpg" alt="HUPO 2025: 24th Human Proteome Organization World Congress" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_HUPO_2025_24th_Human_Proteome_Organization_World_Congress_cover_image_jpg_1256bb4d21.jpg 245w," sizes="100vw" width="1280" height="720"></p><h5><strong>SETAC North America 46th Annual Meeting</strong></h5><ul><li>16–20 November 2025 | Portland, Oregon, USA</li><li><strong>Organizer:</strong> SETAC</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/754">More information and registration at this link</a></li></ul><h5><strong>Eastern Analytical Symposium (EAS) 2025</strong></h5><ul><li>17–19 November 2025 | Plainsboro, NJ, USA</li><li><strong>Organizer: </strong>Eastern Analytical Symposium and Exposition</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/902">More information and registration at this link</a></li></ul><h5><strong>Invited Lecture – Jana Roithová</strong></h5><ul><li>18 November 2025 | IOCB Prague</li><li><strong>Organizer: </strong>IOCB Prague</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/709">More information and registration at this link</a></li></ul><h5><strong>TIAFT 2025</strong></h5><ul><li>23–27 November 2025 | Auckland, New Zealand</li><li><strong>Organizer: </strong>The International Association of Forensic Toxicologists</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/768">More information and registration at this link</a></li></ul><h5><strong>The Gas Chromatographers’ Training Seminar</strong></h5><ul><li>24–25 November 2025 | Online</li><li><strong>Organizer: </strong>Phenomenex</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/741">More information and registration at this link</a></li></ul><h5><strong>Sample Preparation Seminar</strong></h5><ul><li>2–3 December 2025 | Online</li><li><strong>Organizer:</strong> Phenomenex</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/742">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Phenomenex_Training_Courses_2025_c4712b0acc.jpg" alt="Phenomenex: Phenomenex Training Courses 2025" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Phenomenex_Training_Courses_2025_c4712b0acc.jpg 245w," sizes="100vw" width="1539" height="907"></p>

Global GCMS Conferences and Training 2025 – LabRulez

<p><strong>In the week of September 8, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><h4><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 500 GC, LC, MS and spectroscopy webinars</strong>.</h4></blockquote><h5><strong>1. Separation Science: Smart Chromatography Methods for Faster Tech Transfer: A Cross-Platform Case Study</strong></h5><ul><li>Tu, 9.9.2025 17:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5391">Registration</a></li></ul><p>In this session, we’ll take a closer look at why method transfer is such a challenge today — and more importantly, how to fix it.</p><h5><strong>2. Thermo Fisher Scientific: Scalable Pyrolysis-GC-MS for Mapping Plastic Exposure in Environments and Biology</strong></h5><ul><li>We, 10.9.2025 18:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5454">Registration</a></li></ul><p>Join us for this insightful webinar where experts will explore complementary Pyrolysis-GC-MS approaches to detecting and profiling micro- and nano-plastics (MNPs).</p><h5><strong>3. C&amp;EN: Making Sense of Microplastics Data Using YABE, a Reporting Tool for the Agilent 8700 LDIR</strong></h5><ul><li>Th, 11.9.2025 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5421">Registration</a></li></ul><p>Learn how YABE simplifies microplastics data from the Agilent 8700 LDIR. Discover its role in harmonizing analysis, improving reporting, and advancing global plastics research.</p>

Webinars LabRulezGCMS Week 37/2025

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Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

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