<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 15th September 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you posters by <strong>Agilent Technologies / ASMS, Shimadzu / ASMS </strong>and application note by <strong>EST Analytical!</strong></p><h3><strong>1. Agilent Technologies / ASMS: Beyond Aligners: Unmasking Hidden Extractables and Leachables in Orthodontic Devices</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ps_7250_extractables_leachables_asms_2025_tp_318_en_ucsf_3e88cfbf5c.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Increasingly popular in orthodontics, clear aligners promised to users’ improved comfort, compliance and flexibility. It also came with prolonged intraoral exposure. The literature on the potential for leaching components of the polymer used to manufacture the invisible aligners is sparse. Despite the benefits, user submitted cases in the FDA retrospective analysis report several adverse effect ranging from swelling, hives, itchiness and even difficulty breathing1 . Previous works examined the potential of leaching in retainers but used conditions far from the in-vivo setting2 . We used samples closest to user conditions and harnessed the power of Gas Chromatography High Resolution Mass Spectrometry (GC-HRMS) and the power of curated and annotated libraries to find candidate compounds that could be at the origin of the reported adverse effects. We also used multivariate statistics to establish relationships between the compounds and metadata.</p><h4><strong>Experimental</strong></h4><h5><strong>Sample Analysis&nbsp;</strong></h5><p>Samples were analyzed using the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=7250"><strong>Agilent 7250 accurate mass GC-qTOF</strong></a> equipped with the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=8890+GC"><strong>8890 GC</strong></a> and a DB-5MS UI column (30m x 0.25 x 0.25). The inlet temperature was 280°C and the transfer line temperature was 325°C. The oven program was as follows: 50°C for 1 min, ramp at 25°C to 170°C, hold for 1 min; then ramp at 15°C to 300°C, hold for 10 min; then ramp at 20 °C to 325°C and hold for 5 min. The solvent delay was 4 min. The data were acquired in electron ionization (EI) mode using mass range 45 to 1000 m/z. The source temperature was 230°C, and the emission current was 5 µA. A mix of alkanes was run along with the samples and blanks and an Extractables and Leachables (E&amp;L) standard mixture was run as a quality check.&nbsp;</p><h5><strong>Data Analysis&nbsp;</strong></h5><p>Retention indices were used in consolidating library matches in both the Agilent HRMS E&amp;L library and the NIST23 library. Data analysis was conducted on Unknown Analysis software from Agilent that performs compound annotation based on library matching and retention index. All compounds were individually reviewed based on ExactMass, retention index delta and library match factor (Figure 2). Canonical Correlation Analysis was performed using the FactoMineR package in R.</p><h4><strong>Conclusions</strong></h4><p>The aligners used in the current study were approved in the late 90s when E&amp;Ls methods were not as prominent or sensitive as they are today. This study stands out with:&nbsp;</p><ul><li>The first report of numerous E&amp;L compounds with known potential adverse effects in a population of clear aligner users&nbsp;</li><li>Providing an insight of the relationships between E&amp;Ls and user’s metadata such as age, DWT and TSS&nbsp;</li><li>Providing the necessary libraries to find parent compounds and their potential metabolites</li></ul><h3><strong>2. EST Analytical: Optimization of 1,4-Dioxane and Ethanol Detection Using USEPA Method 8260</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Purge_and_Trap_1_4_Dioxane_and_Ethanol_by_8260_App_Note_b669c79f53.pdf"><strong>Full PDF for download</strong></a></li></ul><p>During the manufacture of pharmaceuticals, 1, 4-Dioxane is used as a cleansing agent. It is also a byproduct of plastic manufacturing. The most likely exposure to 1, 4-Dioxane is at an industrial site. However, if any 1, 4-Dioxane is released into the environment during manufacturing there is a potential for it to migrate into ground water. The fact that 1, 4-Dioxane is so miscible in water makes degradation of the chemical challenging. Ethanol, on the other hand, has been a popular gasoline additive. Since it burns more quickly and completely than gasoline, emissions from car exhaust are decreased. The downside of this is underground storage tank leakage and fuel spills cause ground water and drinking water to be contaminated with both the fuel and the ethanol additive. Since ethanol is also very miscible in water, the detection of ethanol contamination in water can be difficult.&nbsp;</p><p>There have been several innovations that help overcome the obstacles of detecting 1, 4-Dioxane and Ethanol. The first one is the SIM mode of the mass spectrometer. This mode allows better detection of hard to extract compounds. Furthermore, mass spectrometers are now equipped to run SIM/Scan, this not only helps detect more difficult compounds, but also enables the detection of an extensive list of USEPA Method 8260 compounds without having to run the samples twice. Advancements in purge and trap sampling have also facilitated better detection of these compounds. Most effective in this has been the ability to heat the samples. However, there are drawbacks to better detection. The most problematic of these is the tendency of 1, 4-Dioxane and Ethanol to “stick” to the glass ware. This susceptibility has caused many headaches in environmental labs.&nbsp;</p><p>This application note will investigate seven variations of purge and trap sampling. The data will then be evaluated in order to recommend the optimum purge and trap sampling parameters for your lab.</p><h4><strong>Experimental</strong></h4><p>The sampling system used for this study was the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2160"><strong>EST Analytical Evolution concentrator</strong></a> affixed with a Vocarb 3000 trap. The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2159"><strong>Centurion WS autosampler</strong></a> equipped with the syringe option was employed as the autosampler. The separation and analysis were performed by an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=7890A"><strong>Agilent 7890A Gas Chromatograph (GC)</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=5975C"><strong>5975C inert XL Mass Spectrometer (MS)</strong></a>. The GC was configured with a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=9&amp;search=Rxi-624+Sil+MS"><strong>Restek Rxi-624 Sil MS</strong></a> 30m x 0.25mm x 1.4µm column. The purge and trap parameters used for this study are listed in Tables 1 and 2 while Table 3 shows the GC/MS parameters.</p><h4><strong>Conclusions</strong></h4><p>All seven purge and trap parameter iterations passed the USEPA Method 8260 requirements for linearity and method detection limits. The problem with some of the experimental parameters was found in the carryover and precision and accuracy studies. The carryover using the traditional sparge vessel showed a large amount of carryover for the Ethanol and 1, 4-Dioxane. Since the carryover was so high, the precision and accuracy data suffered. The Fritless/Bulbless sparge vessel, on the other hand, displayed much lower carryover for the Ethanol and 1, 4-Dioxane especially when the patented sparge bake was not used. However, the 1, 2, 4-Trichlorobenzene, Naphthalene and 1, 2, 3-Trichlorobenzene carryover after the 50ppb standard was above the lower limit of the curve. Thus, the sparge bake would be recommended in order to limit the carryover of the heavier compounds. The optimum purge and trap parameters proved to be the patented water extraction technique. This technique provided linearity and method detection limits that met the USEPA Method 8260 requirements, while providing excellent precision and accuracy data. During water extraction, the sample is transferred to an empty 40ml vial and then purged in the soil station of the Centurion. The “fresh” vial provides a clean sparge vessel for every sample thus limiting carryover for both the Ethanol and 1, 4-Dioxane and for the heavy compounds. This lack of carryover aided in providing optimum precision and accuracy and carryover results and would be the recommended method for examining these troublesome compounds.</p><h3><strong>3. Shimadzu / ASMS: Quantitation of Acetaldehyde, Ethylene Oxide, 2-Chloroethanol, Ethylene Glycol, 1,4-Dioxane &amp; Diethylene Glycol in PEG 3350 by using dynamic headspace GC-MS/MS</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ASMS_2025_TP_301_ad1ab4ac3e.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Polyethylene glycol 3350 (PEG 3350) is used to treat occasional constipation and it is in a class of medications called osmotic laxatives. PEG 3350 is an addition polymer of ethylene oxide and water with formula H(OCH2CH2)n OH, in which n represents the average number of oxyethylene groups. The average molecular weight of PEG 3350 is 3015–3685 g/mol (Da). Acetaldehyde, Ethylene Oxide (EtO), 2-Chloroethanol (2-CE), Ethylene Glycol (EG), 1,4- Dioxane and Diethylene Glycol (DEG) are the probable impurities of PEG 3350. All these above impurities are highly toxic &amp; hazardous substances.&nbsp;</p><p>As per the USP monograph, different chromatography techniques and sample preparation methods are used to quantify above mentioned impurities. This study reports a single sensitive and reliable analytical method for quantitation of all above impurities by using dynamic headspace (Trap) coupled with GC-MS/MS system. Limit of impurities and detail method of analysis are shown in table 1.</p><p>This study reports highly sensitive single method for the simultaneous quantification of multiple probable impurities of PEG 3350 by using dynamic headspace (Trap) coupled with triple quadrupole gas chromatography (GC-MS/MS) system.&nbsp;</p><h4><strong>Materials and methods&nbsp;</strong></h4><p>For this study, individual impurity reference standards were procured from Sigma Aldrich, whereas PEG 3350 powder sample was procured from local medical store. 10% of PEG 3350 powder sample solution (as such sample solution) and respective levels of matrixmatched calibration standard solutions were prepared in acetonitrile. Standard addition method was used to quantify impurities in the PEG 3350 sample. This method was part validated with respect to (w.r.t) precision, linearity/accuracy and sample analysis. <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=GCMS-TQ8050+NX"><strong>GCMS-TQ8050 NX</strong></a> equipped with headspace sampler <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=HS-20+NX"><strong>HS-20 NX </strong></a>(Trap) (Figure 1), manufactured by Shimadzu Corporation Japan, was used to quantify impurities in the PEG 3350 sample</p><h4><strong>Conclusion</strong></h4><ul><li>Trace level quantification of Acetaldehyde, EtO, 2-CE, 1,4-Dioxane, EG and DEG in PEG 3350 sample was successfully performed by using Shimadzu GCMS-TQ8050 NX with HS-20 NX (Trap) dynamic headspace sampler.</li><li>Dynamic headspace mode outperforms the current regulatory limits, delivering multifold times more sensitivity compared to other injection techniques.</li><li>Shimadzu GCMS-TQ8050 NX features a new highly efficient detector and superior noise reduction technology that enhance sensitivity and enables quantitation of impurities even at trace levels.</li></ul>

News from LabRulezGCMS Library - Week 38, 2025

<p><strong>In the week of September 22, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. SelectScience: SelectScience Analytical Science Summit</strong></h5><ul><li>Tu, 23.9.2025 13:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5411">Registration</a></li></ul><p>Join the 5th SelectScience® Virtual Analytical Science Summit to explore the latest analytical chemistry innovations, trends, and solutions for global challenges.</p><h5><strong>2. The Analytical Scientist: Rapid Raw Material ID - From Pallet to Production 50% Faster</strong></h5><ul><li>We, 24.9.2025 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5505">Registration</a></li></ul><p>Discover how the Agilent Vaya handheld Raman with SORS accelerates raw material ID by 50%, streamlining synthetic peptide production and improving pharma manufacturing efficiency.</p><h5><strong>3. GERSTEL: Simultaneous Clean-up of Complex Matrices for the Determination of all 209 PCBs and PCDD/Fs Using the LCTech Dioxin Workflow</strong></h5><ul><li>We, 24.9.2025 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5465">Registration</a></li></ul><p>Discover how the LCTech Dioxin workflow with DEXTech Plus enables simultaneous clean-up of 209 PCBs and PCDD/Fs, ensuring precise HRMS quantification even in complex matrices like soil and fish oil.</p><h5><strong>4. Thermo Fisher Scientific: Reporting in Chromeleon Software</strong></h5><ul><li>Th, 25.9.2025 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5507">Registration</a></li></ul><p>Learn step-by-step how to build detailed Chromeleon 7.3.2 CDS reports. Discover formulas, custom variables, and best practices to streamline data analysis and reporting.</p><h5><strong>5. Agilent Technologies: UV-VIS-NIR in Battery Development</strong></h5><ul><li>Th, 25.9.2025 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/3909">Registration</a></li></ul><p>Agilent's portfolio of instruments offers the high performance and flexible accessories needed for pioneering new applications.</p>

Webinars LabRulezGCMS Week 39/2025

Flavor Characteristics of Different Varieties of Flue-Cured Tobacco Based on Headspace Gas Chromatography–Ion Mobility Spectrometry and Headspace Solid-Phase Microextraction–Gas Chromatography–Mass Spectrometry

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 22nd September 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies, EST Analytical, Shimadzu </strong>and <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: A Chemometric Approach for Ambient Air Monitoring Using Thermal Desorption GC/MS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_voc_8890_chemometric_ambient_air_monitoring_5994_8451en_agilent_fef7d171bb.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Monitoring VOCs is crucial for assessing air quality in industrial and urban settings. These compounds, which include propene, hexachlorobutadiene, and naphthalene, vary in volatility and encompass both polar and nonpolar chemicals. Recognizing the importance of standardized monitoring, the Bureau of Indian Standards (BIS) has developed specific methodologies for these compounds under the IS 5182 series.&nbsp;</p><p>IS 5182-27 focuses on the measurement of vapor-phase organic chemicals such as vinyl chloride and nC22 hydrocarbons in air and gaseous emissions. This method employs diffusive (passive) sampling onto sorbent tubes or cartridges, followed by TD (see Figure 1) and capillary GC analysis. The passive sampling approach offers advantages in terms of ease of deployment and cost-effectiveness, making it suitable for widespread monitoring applications.</p><p>To reveal relevant patterns and sources of variation in these large environmental datasets according to the IS-5182 guidance, this application note proposes chemometric analysis using the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=6&amp;search=TD100-xr"><strong>Markes TD100-xr automated thermal desorber</strong></a> (Figure 2) and the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890+gc"><strong>Agilent 8890 GC system</strong></a> with <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=5977c"><strong>5977C GC/MSD</strong></a> (Figure 3). Chemometrics is a discipline that uses mathematics, statistics, and formal logic to design or select optimal experimental procedures. Chemometric techniques commonly used for clustering are the hierarchical agglomerative cluster analysis and PCA with factor analysis.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>This application note highlights the comparison of different air sampling strategies and shows their effect on qualitative and quantitative analysis of VOCs. Active (pumped) sampling helped with faster analysis, which is required for controlled and sensitive real-time monitoring of ambient air. Chromatograms of air sampled at various locations showed the presence of VOCs such as benzene, toluene, ethyl benzene, and xylenes. Many common and unique compounds were found at each location. The intensity of these compounds showed variations at different locations. Fewer compounds with lower intensities were observed in air samples from a residential area, whereas more compounds with higher intensities were observed in air samples from a traffic area.&nbsp;</p><p>Passive sampling was a comparatively cost‑effective and long-term approach and provided consistent replicate results. The chromatographic overlays of different sampling times indicated an increasing trend in peak intensities with respect to time. There was a considerable rise in peak intensities for the 1-week sampling period, as compared to 24-hour sampling. There was a slight rise in peak intensities for the 2-week sampling period, as compared to 1-week sampling. The PCA plot suggested the peak distribution obtained in each dataset. One-week sampling results showed consistent replicate results. Use of the chemometrics software Agilent Mass Profiler Professional added value by providing data visualization for interpretation.</p><h3><strong>2. EST Analytical: USEPA 524.2 Method Validation Using the Evolution Purge and Trap Concentrator and the Centurion WS Autosampler</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Purge_and_Trap_524_2_Application_Note_2d327854f2.pdf"><strong>Full PDF for download</strong></a></li></ul><p>USEPA Method 524.2 calls for purge and trap sampling coupled with a Gas Chromatograph (GC) and Mass Spectrometer (MS) for separation and analysis. It has an extensive list of compounds and requires lower detection limits due to its use in drinking water testing. A 20% relative standard deviation for compound response factors is required across the calibration curve while the calibration check standard analytes have to be within 30% of the expected concentration.&nbsp;</p><p>Currently, this method calls for a 5mL or 25mL purge volume and a four minute desorb time. These method requirements can pose a challenge for the analyst due to the amount of moisture that is created. The negative effects of the increased water vapor include instability of the chromatography, band eluting and poor peak shape to name a few. A side effect of this instability is sample re-runs and lost laboratory productivity. In addition, a common practice for mitigating moisture is increasing the GC inlet split rate. This poses yet another difficulty as the increased split rate can result in reduced sensitivity. EST Analytical’s eight port valve in the Evolution purge and trap concentrator aids in limiting the water exposure because the water management of the system is not part of the desorb pathway. This feature also enables laboratories to use a smaller split ratio at the GC inlet thus increasing sensitivity.</p><h4><strong>Experimental</strong></h4><p>The sampling system used for this study was the<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2160"><strong> EST Analytical Evolution purge and trap concentrator </strong></a>and the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2159"><strong>Centurion WS autosampler</strong></a>. The concentrator was affixed with a Vocarb 3000 trap and connected to an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=7890A"><strong>Agilent 7890A GC</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=5975C"><strong>5975C inert XL MS</strong></a>. The GC was configured with a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=9&amp;search=Rxi-624+Sil+MS"><strong>Restek Rxi-624 Sil</strong></a> MS 30m x 0.25mm x 1.4µm column. Sampling parameters are listed in Table 1 while Table 2 enumerates the GC/MS parameters.</p><h4><strong>Conclusions</strong></h4><p>This study demonstrated the effectiveness of the Evolution/Centurion purge and trap sampling system. The results passed all of the USEPA Method 524.2 criteria for both linearity and detection limits. Since the Evolution bypasses the water management trap during the four minute desorb process, the amount of water effecting the experiments was limited. Furthermore, the forty to one split ratio at the GC inlet provided excellent detection limits as the system was more sensitive to the low level standard requirements of the method. The lower split rate has an added benefit of reducing laboratory helium consumption when setting it against other system’s higher split ratios. Finally, the precision and percent recovery results showed the reliability of the system in producing accurate experimental findings.</p><h3><strong>3. Shimadzu: Dual-Column Analysis of Blood AlcoholContent (BAC) Using Nitrogen Carrier Gas with </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Brevis+GC-2050"><strong>Brevis GC-2050</strong></a></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00899_en_af0d9bafe7.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Analysis of blood alcohol content (BAC) and other volatile organic compounds (VOCs) is essential for law enforcement agencies to determine alcohol intoxication and its role in traffic accidents, assaults, and injuries, as well as to identify the causes of certain criminal behaviors, poisonings, and so on.&nbsp;</p><p>Typically, this analysis is performed by a gas chromatograph (GC) that is combined with a headspace sampler (HS) and a flame ionization detector (FID). Since accurate results are essential with BAC analysis, 2 columns can be used with different separation characteristics so that cross-checking can be performed. By using an integrated HS-GC system equipped with 2 FIDs connecting to a dual-column configuration, crosschecking can be performed in a single analysis. In this system, the columns are directly connected to the transfer line using a 2-hole ferrule, which minimizes sample losses due to adsorption.&nbsp;</p><p>In addition to the high-end <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexis+GC-2030"><strong>Nexis GC-2030</strong></a>, Shimadzu also offers the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Brevis+GC-2050"><strong>Brevis GC-2050</strong></a> as a compact gas chromatography solution, and in this Application News, it is used with an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=HS-20+NX+headspace+sampler"><strong>HS-20 NX headspace sampler </strong></a>(Fig. 1) to perform BAC analysis. Hydrogen was used as the carrier gas in a similar experiment in Application News 01-00570, but in this experiment, nitrogen was used because it is a cheaper alternative carrier gas. Nitrogen generally has an adverse effect on separation, so this experiment also investigated the conditions for separation for 10 types of blood VOCs.</p><h4><strong>Separation of 10 Blood VOCs&nbsp;</strong></h4><p>A solution of 10 VOCs spiked with blood (0.1 mg/mL) was analyzed to determine the separation of methanol, acetaldehyde, ethanol, isopropyl alcohol, acetonitrile, acetone, tert-butanol, 1-propanol, methyl ethyl ketone, and ethyl acetate. The resulting chromatogram is shown in Fig. 6. All peaks were detected within 6.0 minutes in the BAC PLUS1 column and within 3.5 minutes in the BAC PLUS2 column, indicating good separation. The elution sequence of the 10 blood VOCs differed significantly between the columns, which enhanced the system’s qualitative capability. Table 4 shows the retention time of each compound and the repeatability (n=5) of the peak area ratio for the tert-butanol internal standard.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>This experiment involved dual-column analysis of blood alcohol content (BAC) by the compact Brevis GC-2050 and the HS-20 NX. Dual-column configuration enables cross-checking in a single analysis. In addition, nitrogen was used as the carrier gas instead of helium. While hydrogen enables high-speed analysis, it also requires careful handling, so from the perspective of safety, installation of various optional tools such as hydrogen sensor and stop valve have been recommended. Nitrogen gas is relatively inexpensive and easy to handle, and this experiment demonstrated that it also provides reliable results while maintaining good separation.</p><h3><strong>4. Thermo Fisher Scientific: Routine analysis of 7N high purity gallium phosphide by Glow Discharge Mass Spectrometry</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_003578_ioms_gd_ms_element_gd_plus_gallium_an003578_em_en_1666255eb4.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Gallium phosphide (GaP) is a semiconductor material used in electronic and optoelectronic devices, including light-emitting Diodes (LEDs), solar cells as well as high-frequency and high-power electronics<sup>1-5</sup>. GaP wafers offer several advances over traditional silicon wafers, including high efficiency, high-speed operation, and highpower handling capabilities<sup>4-5</sup>.&nbsp;</p><p>This application note describes the direct analysis of impurities in high purity gallium phosphide with sub-ppb detection limits using the Thermo Scientific <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1690"><strong>Element GD PLUS GD Mass Spectrometer</strong></a>.&nbsp;</p><h4><strong>Experiment&nbsp;</strong></h4><p>The flat samples are analyzed directly, with no digestion required. Instrumental conditions for the analysis with the Element GD PLUS GD-MS are shown in Table 1. Potential sample surface contaminations were removed by short presputtering within the instrument.&nbsp;</p><h4><strong>Method development&nbsp;</strong></h4><p>The developed method ensures a reliable separation of interferences from the analyte ions. The interferences PO, POH and GaGa could potentially lead to falsely high Ti, Ba and Ce results. The formation of these interferences is low in the fast-flow source of the Element GD PLUS GD-MS: 69Ga69Ga/69Ga ≈ 1 ppm and ( 31P16O1 H + 31P17O)/31P ≈ 10 ppm. They can easily be resolved at Medium Mass Resolution (R = M / Δm = 4000). This is visualized in the mass scans shown in Figures 1 and 2 with much wider mass windows than later being used for quantification. Therefore, the Medium Mass Resolution of the Element GD PLUS GD-MS enables interference free measurements of Ti, Ba and Ce in GaP matrix.</p><h4><strong>Conclusions&nbsp;</strong></h4><p>Trace contaminations in 7N high purity gallium phosphide can be determined reliably and routinely with the Element GD PLUS GD-MS without prior digestion.&nbsp;</p><p>While most analytes like Ti, Ba and La are resolved from interferences in medium mass resolution (R = 4000), high mass resolution (R = 10000) is required for Ag because of the GaAr interference. Sub-ppb detection limits, even for elements like Sb and Ge, are achieved by neglectable formation of triatomic interferences and reduced abundance sensitivity. That is enabled by the fast-flow source design and the reverse Nier-Johnson geometry.</p><p>Semiquantitative quantification of element concentrations can be performed without standard reference materials using the standard RSF factor approach. The high sensitivity of the instrument, the reliable separation of interferences in medium and high mass resolution, the outstanding peak stability, the low formation of interferences and the low abundance sensitivity enable limits of detection of 0.05 to 1 ppb for most elements.&nbsp;</p><p>The sum of all impurities in the GaP sample was below 50 ppb, implying that a purity of 7N GaP can be assessed with the instrument.</p>

News from LabRulezGCMS Library - Week 39, 2025

<p><strong>In the week of September 29, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Thermo Fisher Scientific: Advanced analytical methods in polymer science, Part 1</strong></h5><ul><li>Tu, 30.9.2025 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5455">Registration</a></li></ul><p>Free webinar on polymer science! Learn how rheology, FTIR, NIR, Raman, XRF, and XRD enhance polymer analysis, quality control, and material design. Live sessions with expert speakers.</p><h5><strong>2. Thermo Fisher Scientific: Advanced analytical methods in polymer science, Part 2</strong></h5><ul><li>We, 1.10.2025 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5456">Registration</a></li></ul><p>Discover cutting-edge applications in polymer science! Learn about plastic sorting, multilayer analysis, and marine waste extrusion from leading experts.</p><h5><strong>3. Thermo Fisher Scientific: Advanced analytical methods in polymer science, Part 3</strong></h5><ul><li>Th, 2.10.2025 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5457">Registration</a></li></ul><p>Explore hyphenated techniques in polymer science! Learn Rheo-Raman, Raman-assisted extrusion, and TGA-IR for advanced material analysis in this free webinar.</p>

Webinars LabRulezGCMS Week 40/2025

Synthesis and Identification of 3-Oxazolines in Cocoa

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 29th September 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies </strong>and<strong> EST Analytical, </strong>poster by<strong> Shimadzu </strong>and smart note by <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: Equimolar Response to ASTM D5623 Relevant Sulfur Compounds</strong></h3><p><strong>Using an </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=8890+GC"><strong>Agilent 8890 gas chromatograph</strong></a><strong> and </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=8355%C2%A0SCD"><strong>8355 sulfur chemiluminescence detector (GC/SCD)</strong></a></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_equimolar_response_astm_d5623_sulfur_compounds_5994_8562en_agilent_62a37181e4.pdf"><strong>Full PDF for download</strong></a></li></ul><p>For many years, the use of a sulfur-specific detector in the petroleum industry has been invaluable for accurately identifying low levels of sulfur-containing compounds in petroleum at various stages of production.<sup>1</sup> Many environmental and health requirements limit the amount of sulfur allowed in the final petroleum product. The presence of sulfur also has the potential to poison the catalytic processes that take place during petroleum refining.&nbsp;</p><p>Along with the determination of low sulfur levels in a petroleum sample, a detector may also need to measure high sulfur levels and total sulfur content. A detector with a high linear range is essential in making both low-level and high‑level determinations of sulfur in a petroleum sample.&nbsp;</p><p>In this application note, an Agilent 8355 SCD was used to measure 19 sulfur-containing compounds within a standard sample. The 8355 SCD is ideal for the widely used ASTM&nbsp;D5623 method<sup>2</sup> because of its ability to obtain linear and equimolar responses to sulfur compounds with minimal hydrocarbon interference. When comparing the equimolar response of analytes containing different numbers of sulfur atoms, the response should be double for the analytes containing two sulfur atoms compared to those with one&nbsp;sulfur atom.&nbsp;</p><p>Another advantage of the 8355 SCD is the ability to use it in tandem with an FID. This combination allows monitoring solvent elution through the GC system, assisting in the detection of the coelution of solvents with analyte peaks. These coelutions can cause peak distortion, which might be mistaken for activity issues within the GC system.</p><h4><strong>Methods&nbsp;</strong></h4><h5><strong>Instrumentation&nbsp;</strong></h5><p>Two <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=8890+GC"><strong>Agilent 8890 GC systems</strong></a> were equipped with an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=8355%C2%A0SCD"><strong>8355&nbsp;SCD</strong></a>. Both GC/SCD systems were run in the same manner to confirm equimolar results. A third GC system was also configured with a tandem flame ionization detector sulfur chemiluminescence detector (FID/SCD) to allow the determination of the solvent peak elution from the system. This third system also served as another confirmation of the equimolar results that were obtained from the other two GC/SCD systems. Sample introduction for all systems was completed with an Agilent <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=7693A+automatic+liquid+sampler"><strong>7693A automatic liquid sampler</strong></a> with a 5 µL syringe. The sample volume for each injection was 1.0 µL. All analyses were performed with a split/splitless inlet in split mode.&nbsp;</p><p>The GC/SCD parameters are provided in Table 1. Note that an Agilent DB-Sulfur SCD GC column (part number G3903-63002) was used in this study because of the low column bleed and excellent inertness and performance for sulfur compound analysis. When using the SCD, be aware that stationary phase bleed from the GC column can lead to fouling of the ceramic tubes within the detector. This phenomenon can cause poor SCD performance, such as decreased sensitivity, and may require more frequent maintenance. Proper GC column selection (such as the DB-Sulfur column) is important to ensure lower column bleed into the detector and will reduce fouling of ceramic tubes, reducing instrument downtime.</p><h4><strong>Results and discussion</strong></h4><h5><strong>Use of GC/FID for solvent elution determination&nbsp;</strong></h5><p>Determination of the solvent peak elution can be a challenge when using a sulfur-selective detector such as the SCD. Many times, the large, fronting solvent peak may coelute with analytes of interest, causing distortion of the analyte peak shape (peak tailing, fronting, or broadening) and poor chromatographic separation. This poor peak shape, caused by column overloading, can be mistaken for activity issues in the system or hydrocarbon interferences, leading to unnecessary troubleshooting or inlet/column maintenance. Determination of the solvent peak elution time is recommended to ensure that coelution does not occur with any of the analytes of interest. To confirm the solvent elution time, a tandem GC/FID/SCD system was used. The GC/FID/SCD system puts the FID in-line before the SCD analysis, allowing the user to obtain both FID and SCD signals from a single injection, thus confirming the solvent retention time and determining any solvent/analyte coelutions.&nbsp;</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The Agilent 8355 sulfur chemiluminescence detector, paired with an Agilent 8890 GC, was evaluated by analyzing 19&nbsp;sulfur‑containing compounds relevant to ASTM D5623. The SCD met the specifications of the test method, including an equimolar response to the analyzed sulfur compounds and a wide range of linearity to a sulfur-containing standard. The 8355 SCD shows excellent area reproducibility, and when used in tandem with a flame ionization detector, the system can aid in the determination of solvent peak elution through the GC system.</p><h3><strong>2. EST Analytical: Reducing Carryover in Environmental Water Samples</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Purge_and_Trap_Reducing_Carryover_in_Environmental_Water_Samples_6e5ba0a008.pdf"><strong>Full PDF for download</strong></a></li></ul><p>In order to mitigate carryover, many environmental labs resort to running sample dilutions or adding blank samples after a highly contaminated sample. Both of these solutions are not ideal and can lead to a loss of analyte detection when diluting or a loss of profits when blank samples need to be run.</p><p>Since, the primary source of carryover for water samples is the sparge vessel, purge and trap manufactures have incorporated a rinsing step in which the sparge vessel is “washed” with hot water in order to clean up the volatile compounds that may still reside in the sparge vessel. Expanding on the idea of limiting volatile compounds in the sparge vessel, EST Analytical developed a patented process of heating the sparge vessel during the bake step of the purge and trap process (Patent Number: US 8,075,842 B1) . This engineering innovation essentially performs two bakes; as a result both the trap and the sparge vessel are “cleaned” at the same time. No other concentrator is or can be engineered to do this.</p><h4><strong>Experimental</strong></h4><p>The sampling system used for this study was the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2160"><strong>EST Analytical Evolution concentrator</strong></a> and the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2159"><strong>Centurion WS autosampler</strong></a>. The concentrator was affixed with a Vocarb 3000 trap and connected to an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=7890A"><strong>Agilent 7890A GC </strong></a>and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=5975C"><strong>5975C inert XL MS</strong></a>. The GC was configured with a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=9&amp;search=Rxi-624+Sil+MS"><strong>Restek Rxi-624 Sil</strong></a> MS 30m x 0.25mm x 1.4µm column. Refer to Table 1 for the sampling method parameters and Table 2 for GC/MS parameters.</p><h4><strong>Conclusions</strong></h4><p>The Evolution purge and trap concentrator with its patented technique of heating the sparge vessel during the bake process proved to reduce carryover by almost half when comparing with hot water rinses alone. The advantages of reduced carryover are many. Primary among them is the ability to run more samples during the twelve hour tune window. This increase in productivity translates to more laboratory profits and better use of instrument time.</p><h3><strong>3. Shimadzu / AOAC: Analysis of PFAS in juice using Head-Space Solid Phase Microextraction-Gas Chromatography/Mass Spectrometry (HS-SPME GCMS)</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/aoac_2025_t010_9967ebebff.pdf"><strong>Full PDF for download</strong></a></li></ul><p>PFAS contaminate water and food through packaging that can leach volatile PFAS from plastics and inks or coatings. This work developed a headspace SPME GCMS method to analyze six volatile PFAS classes in juices. The United States Food and Drug Administration has tested for PFAS in a broad range of foods and beverages as part of its Total Diet Study. Juice matrices differ in flavor, sugar, as well as manufacturing practices, and packaging, with the latter two potentially introducing PFAS contamination. The former differences between products can impact PFAS detection.</p><h4><strong>Materials and Methods</strong></h4><p>The SPME method used in this study is based on a method published by Bach et.al. (2016). An HS-SPME method is used to improve method performance when analyzing complex aqueous samples over direct immersion. The optimized parameters of the instrument method for the targeted PFAS are listed in table 1.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=GCMS-TQ8040+NX"><strong>Shimadzu GCMS-TQ8040 NX triple quadrupole instrument</strong></a>, configured with an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=AOC-6000+Plus+SPME"><strong>AOC-6000 Plus SPME</strong></a> unit, was used to measure PFAS in different juice samples. Without isotope dilution, matrix effects caused recoveries to fall outside of acceptable criteria. Method blanks showed no detectable PFAS, and calibration demonstrated excellent linearity (R² ≥ 0.993). This HS-SPME GCMS-TQ8040 NX method demonstrated quantitative capability for analyzing nanogram-per-liter PFAS compounds in complex juice matrices. This application highlights a simple, fast, robust, precise, and accurate workflow for measuring volatile PFAS in challenging matrices.</p><h3><strong>4. Thermo Fisher Scientific: Safe use of carrier hydrogen for air monitoring with Multi-Gas TD-GC-MS</strong></h3><ul><li>Other document (smart note)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/sn_003958_gc_single_quad_gc_ms_isq_7610_environmental_sn003958_na_en_8216fc7021.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Monitoring volatile organic air compounds, also known as hazardous air pollutants (HAPs), is crucial for maintaining air quality in urban and industrial environments due to their significant health risks. The growing concerns about these potentially dangerous volatile organic compounds in ambient air, particularly in urban areas and from industrial emissions, have led to the development of numerous national and international regulations. The use of Thermal Desorption (TD) coupled with GC-MS is the analytical technique of choice to enrich volatile organic compounds from air and quantify them at trace levels.1 In gas chromatography, the choice of carrier gas is pivotal for the separation and detection of VOCs. Helium has traditionally been the preferred carrier gas for analyzing volatile organic air toxics due to its inertness and performance benefits. However, hydrogen is becoming increasingly popular due to economic and supply considerations. Each carrier gas has unique advantages and challenges, and the choice should be guided by specific analytical requirements, cost constraints, and safety protocols. As the demand for sustainable and cost-effective solutions grows, hydrogen is expected to play a more significant role in monitoring hazardous air pollutants in urban and industrial settings.</p><p>Thermal Desorption is an established way to analyze VOCs in a wide variety of sample types. This smart note highlights the use of the new Multi-Gas TD system (Markes International) that allows a safe use of carrier hydrogen for the analysis of VOCs in air, enhancing operational flexibility and supporting more sustainable laboratory practices.&nbsp;</p><h4><strong>Experimental&nbsp;</strong></h4><p>In this study, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=7&amp;search=TD100-xr"><strong>Markes TD100-xr™ Multi-Gas system</strong></a>, coupled with the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/486"><strong>Thermo Scientific™ TRACE™ 1610 gas chromatograph</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/484"><strong>Thermo Scientific™ ISQ™ 7610 single quadrupole mass spectrometer,</strong></a> was employed to accurately detect and quantify compounds for effective air monitoring. This combination leverages several technological advancements to optimize analytical performance and operational efficiency.</p><p>The comparison between helium and hydrogen carrier gas was carried out using the same analytical column. The method conditions for all analytes could be easily transferred. Flow rates were adjusted using the split ratio calculator available in the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/76"><strong>Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</strong></a> Instrument Method Wizard (Figure 1) to maintain the same split level and therefore the same amount of transferred sample. A further factor facilitating rapid adoption of hydrogen carrier gas in laboratories is that existing columns and consumables can be used without restrictions.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The use of the Markes TD100-xr Multi-Gas system combined with the ISQ 7610 GC-MS for the analysis of VOC in air allows for a safe use of carrier hydrogen, making it a viable alternative to helium and offering an effective solution for laboratories facing the challenges of helium scarcity and rising costs, while maintaining the accuracy and reliability of VOC detection and quantification.&nbsp;</p><ul><li>The comparative analysis clearly confirmed that using hydrogen carrier gas in gas chromatography offers substantial benefits over helium. The significant reduction in retention time, as shown by the 60% decrease for 1,2,3-trichlorobenzene, leads to faster analysis without compromising the separation efficiency.&nbsp;</li><li>Enabling shorter analysis time, hydrogen enhances laboratory productivity, reduces costs, and contributes to more sustainable practices.&nbsp;</li><li>The results also indicate that both helium and hydrogen can be used effectively as carrier gases without impacting the response linearity for the VOC compounds under evaluation. Laboratories can confidently use hydrogen as an alternative to helium for quantitative analysis, ensuring accurate and reliable analytical results.</li><li>When using multiple carrier gases, the ISQ 7610 NeverVent technology is key to easily switching from helium to hydrogen and back to helium with no venting required, making this operation very quick and safe.&nbsp;</li></ul><p>In conclusion, coupling the Markes TD100-xr Multi-Gas system with the ISQ 7610 single quadrupole GC-MS offers a robust and flexible solution for air monitoring. This integration enhances operational efficiency, reduces costs, and maintains high data integrity, making it an invaluable tool for modern analytical laboratories.</p>

News from LabRulezGCMS Library - Week 40, 2025

<p><strong>In the week of October 6, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. LECO: Sloppy Disposal – A Combination of Targeted and Non-Targeted GCxGC-HRT Investigations of DDT Manufacturing Waste Products</strong></h5><ul><li>Tu, 7.10.2025 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5510">Registration</a></li></ul><p>Explore targeted and untargeted GC×GC-HRT sediment core analysis of DDT waste from deep-sea dumps near Los Angeles, revealing persistent pollutants and their environmental impact.</p><h5><strong>2. Agilent Technologies: Seminar 1 – OpenLab CDS - The Control Panel and Data Acquisition</strong></h5><ul><li>Tu, 7.10.2025 18:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/555">Registration</a></li></ul><p>The Control Panel is the gatekeeper to the system. Explore software features supporting user authentication, system configuration, acquisition methods, and reporting.</p><h5><strong>3. Agilent Technologies: Hydrogen Value Chain: Fueling Green Mobility</strong></h5><ul><li>We, 8.10.2025 07:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5540">Registration</a></li></ul><p>Learn how Agilent GC solutions ensure hydrogen purity by detecting trace impurities and supporting certification for fuel-cell and industrial applications.</p><h5><strong>4. New Food magazine: From Calibration to Confidence: Building Trust in Process NIR</strong></h5><ul><li>We, 8.10.2025 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5395">Registration</a></li></ul><p>Build trust in Process NIR by aligning lab and production teams. Learn how to validate results, overcome doubt, and integrate NIR for real-time quality control in food production.</p><h5><strong>5. Thermo Fisher Scientific: Reduce manual integrations: Optimize data processing with detection parameters and algorithms</strong></h5><ul><li>We, 8.10.2025 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5385">Registration</a></li></ul><p>Master detection in Chromeleon CDS—learn to configure parameters, choose the right algorithms, and boost data accuracy. Live Q&amp;A with Thermo Fisher experts.</p><h5><strong>6. Technology Networks: Advancing Therapeutic Protein Production With Real-Time Analysis</strong></h5><ul><li>Th, 9.10.2025 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5511">Registration</a></li></ul><p>Discover how precise, non-destructive, real-time insights into protein production empower teams to make faster, data-driven decisions.</p><h5><strong>7. Agilent Technologies: Common Pitfalls in GC Chromatography: What to Avoid</strong></h5><ul><li>Th, 9.10.2025 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5042">Registration</a></li></ul><p>Learn about common GC pitfalls that can cause analytical issues and discover strategies to avoid them for more robust chromatography.</p><h5><strong>8. Shimadzu Corporation: GC-SCD for Petroleum Products: Comparison of Commercially Available Sulfur Chemiluminescence Detectors by ASTM D5623</strong></h5><ul><li>Th, 9.10.2025 20:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5512">Registration</a></li></ul><p>Compare three GC-SCD systems for sulfur analysis in petroleum per ASTM D5623. Learn about sensitivity, robustness, and ways to cut maintenance costs in sulfur speciation.</p>

Webinars LabRulezGCMS Week 41/2025

<p><strong>This study provides the first description of the essential oil distilled from Aiouea dubia, a native Andean species. Chemical analyses by GC–MS and GC-FID identified major terpenes including germacrene D, γ-muurolene, limonene, δ-cadinene, cyclosativene, and (E)-β-caryophyllene.</strong></p><p>Enantioselective GC revealed 11 chiral terpenes, with (−)-α-pinene and (−)-3-carene occurring in enantiopure form and others as scalemic mixtures. Given its high limonene and β-caryophyllene content, the oil shows potential antibacterial and anti-inflammatory properties, highlighting its promise in cosmeceutical applications.</p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c05278"><strong>The Chemical and Enantioselective Analysis of a New Essential Oil Produced by the Native Andean Species Aiouea dubia (Kunth) Mez from Ecuador</strong></a></h4><p>Katherin Fiallos, Yessenia E. Maldonado, Nixon Cumbicus, and Gianluca Gilardoni*</p><p>ACS Omega 2025, 10, 38, 44077–44086</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acsomega.5c05278">https://doi.org/10.1021/acsomega.5c05278</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><p><strong>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.</strong></p><p>Since ancient times, plants have been used as drugs and as a source of fragrances, for both cosmetic and ritual purposes. With the introduction of the scientific method, these properties have been attributed to the presence of secondary or specialized metabolites, whose purification and structure elucidation greatly contributed to the progress of medicinal chemistry and cosmetology. Nowadays, most of the European botanical species have been phytochemically investigated, and their metabolic profiles are quite well-known. Therefore, in search for new natural products, chemists are currently focusing on the flora of so-called “megadiverse countries”, whose biodiversity includes a great fraction of all biological species around the world. <a href="javascript:void(0);">(1)</a> Among the megadiverse countries, Ecuador is included. In this territory, historical and logistical reasons avoided that most of the native and endemic botanical species could be so far studied for their metabolic content. <a href="javascript:void(0);">(2,3)</a> For these reasons, our group has been investigating the Ecuadorian biodiversity for more than 20 years, in search for new natural molecules, biologically active compounds, and unprecedented essential oils (EOs). <a href="javascript:void(0);">(4−9)</a> In this context, some of the authors recently described a volatile fraction from <i>Aiouea montana</i> (Sw.) R. Rohde, whose composition was dominated by a peculiar, sulphurated compound, responsible for the strong unpleasant smell of the leaves. <a href="javascript:void(0);">(10)</a> On the other hand, the leaves of the less common <i>Aiouea dubia</i> did not present a similar smell but a pleasant, quite sweet fragrance. From the botanical point of view, the genus <i>Aiouea</i> Aubl. is currently considered, by some botanists, the correct classification for all the Neotropical taxa, that were previously included into the genera <i>Phoebe</i> and <i>Cinnamomum</i>. <a href="javascript:void(0);">(11)</a> The taxon <i>Aiouea</i> is therefore native of America, and it includes 73 species with an accepted name, whereas the reported synonyms are more than 200. <a href="javascript:void(0);">(12)</a> For what concerns <i>A. dubia</i>, this species is a shrub, treelet or tree, native of the Andes, and diffused from Venezuela to Peru. <a href="javascript:void(0);">(12−14)</a> In Ecuador, this plant grows in the range between 2000 and 3000 m above the sea level, being described in the provinces of Loja and Zamora-Chinchipe. <a href="javascript:void(0);">(14)</a> Some synonyms are also reported for <i>A. dubia</i>, such as <i>Aiouea granatensis</i> Mez, <i>Aiouea jelskii</i> Mez, <i>Aiouea tambillensis</i> Mez, <i>Aiouea truxillensis</i> Kosterm, <i>Cryptocarya dubia</i> Kunth, <i>Endocarpa corymbosa</i> Raf., <i>Laurus hypericifolia</i> Willd. ex Nees, and <i>Persea hypericifolia</i> Nees. So far, to the best of the authors’ knowledge, only the EOs from <i>Aiouea costaricensis</i>, <i>Aiouea maguireana</i>, and <i>A. montana</i> have been investigated within this genus, whereas no literature has been found describing the chemical and the enantiomeric profiles of any volatile fraction from <i>A. dubia</i> or its synonyms. <a href="javascript:void(0);">(10,15,16)</a> With these premises, the species <i>A. dubia</i> (Kunth) Mez (Lauraceae) was selected to be analyzed for the chemical and enantiomeric compositions of its EO. Main purposes of the present study were contributing to the preservation of the Ecuadorian biodiversity through the phytochemical knowledge and identifying potential sources of new natural products, suitable to be the object of bioeconomic applications.</p><h3><strong>Methods</strong></h3><h4><strong>Qualitative (GC–MS) Chemical Analyses</strong></h4><p>The qualitative chemical composition of <i>A. dubia</i> EO was carried out through gas chromatography, using mass spectrometry as a detection technique (GC–MS). The GC instrument was a gas chromatograph model <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=3&amp;search=trace+1310"><strong>Trace 1310</strong></a>, purchased from Thermo Fisher Scientific (Waltham, MA, USA). The GC was coupled with a single quadrupole mass spectrometer (MS) model <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=3&amp;search=ISQ+7000"><strong>ISQ 7000</strong></a>, purchased from the same provider. The qualitative analyses were conducted with two capillary columns, based on stationary phases of different polarity: 5%-phenyl-methyl-polysiloxane (<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1785"><strong>TR-5 ms, nonpolar</strong></a>) and polyethylene glycol (<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1791"><strong>TR-Wax, polar</strong></a>), purchased form Thermo Fisher Scientific (Waltham, MA, USA). Both columns were characterized by the following dimensions: 30 m in length, internal diameter of 0.25 mm, and film thickness of 0.25 μm. The thermal program was 50 °C for 10 min, followed by an initial gradient of 2 °C/min up to 170 °C, then a second gradient of 10 °C/min up to 230 °C, which was finally maintained for 20 min. All the injections were conducted in split mode (40:1), with helium as a carrier gas, provided by Indura s.a. (Guayaquil, Ecuador), and maintained at the constant flow of 1 mL/min. Injector and transfer line were set at the temperature of 250 °C. The mass spectrometer detector was equipped with an electron ionization source, set at the ionization energy of 70 eV. The detector was operated in SCAN mode, detecting ions within the mass range of 40–400 amu. Both ion source and quadrupole temperatures were 250 °C. All the EO constituents were identified by comparison of each MS spectrum and linear retention index (LRI) with data from literature. The LRIs were calculated according to Van den Dool and Kratz, <a href="javascript:void(0);">(67)</a> based on a series of homologous <i>n</i>-alkanes in the range C<sub>9</sub>–C<sub>24</sub>. The alkanes were provided by Merck (Sigma-Aldrich, St. Louis, MO, USA).</p><h4><strong>Quantitative (GC-FID) Chemical Analyses</strong></h4><p>The quantitative chemical analyses were conducted with the same GC instrument and the same columns described for the qualitative ones, but with a flame ionization detector (FID), set at 280 °C, instead of the mass spectrometer. Carrier gas, constant flow, injection temperature and mode, and oven thermal program were the same as the qualitative analyses. All the detected compounds were quantified calculating the relative response factor (RRF) of each constituent according to the respective combustion enthalpy, as described by Chaintreau. <a href="javascript:void(0);">(68,69)</a> The integration areas, corrected by the RRFs, were applied to two six-point calibration curves (one for each column), that were traced using <i>n</i>-nonane as internal standard and isopropyl caproate as calibration standard. The internal standard was provided by Merck (Sigma-Aldrich, St. Louis, MO, USA), whereas the calibration standard was synthesized in the authors’ laboratory and purified to 98.8% (GC-FID purity). Both curves produced coefficients of determination <i>R</i><sup>2</sup> &gt; 0.998, with standard dilutions prepared as previously described in literature. <a href="javascript:void(0);">(70)</a></p><h3><strong>Results and Discussion</strong></h3><h4><strong>Chemical Analysis</strong></h4><p>The dry leaves of <i>A. dubia</i> afforded, after preparative steam-distillation, a clear pale-yellow oil, characterized by a sweet light fragrance. The distillation yield, by weight, was 0.3%. A total of 69 compounds were detected and quantified on at least one of two chromatographic columns. The columns were coated with different stationary phases, being 5%-phenyl-methyl-polysiloxane a nonpolar phase and polyethylene glycol a polar phase. The great difference in polarity among these two phases ensured that chromatographic properties were also different enough to obtain a good separation, for almost all compounds, on at least one column. Furthermore, different chromatographic properties produced different linear retention indices for a same compound, ensuring a more reliable identification through the coincide of both linear retention indices with data from literature. Finally, these specific stationary phases are the most used in EO analysis, ensuring that a lot of literature is available as a source of reference linear retention indices. The total mass of the quantified components corresponded to 85.1%–82.8% of the whole oil mass, expressed as the sum of all quantified compounds on the nonpolar and polar column, respectively. This volatile fraction was dominated by sesquiterpenes and sesquiterpenoids, corresponding together to 65.5%–61.4% of the total amount. Major components of the EO (≥3.0% on at least one column) were germacrene D (12.2%–11.7%, <strong>45</strong>), γ-muurolene (7.6%–7.2%, <strong>44</strong>), limonene (6.8%–6.2%, <strong>14</strong>), δ-cadinene (6.4%–5.9%, <strong>51</strong>), cyclosativene (6.0%–5.5%, <strong>32</strong>), and (<i>E</i>)-β-caryophyllene (4.4%–4.0%, <strong>36</strong>). The chemical structures of the main EO components are represented in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c05278#fig1">Figure 1</a>, whereas the gas chromatographic (GC) profiles, obtained on a nonpolar and a polar stationary phase, are respectively represented in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c05278#fig2">Figure 2</a> and <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c05278#fig3">Figure 3</a>. The complete qualitative and quantitative analyses are reported in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c05278#tbl1">Table 1</a>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2025_10_38_44077_44086_Figure_1_Major_components_ab66263628.jpg" alt="ACS Omega 2025, 10, 38, 44077–44086: Figure 1. Major components (≥3.0% on at least one column) of A. dubia leaf EO. The numbers refer to Table 1: limonene (14), cyclosativene (32), (E)-β-caryophyllene (36), γ-muurolene (44), germacrene D (45), and δ-cadinene (51)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2025_10_38_44077_44086_Figure_1_Major_components_ab66263628.jpg 245w," sizes="100vw" width="3222" height="670"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2025_10_38_44077_44086_Figure_2_GC_MS_profile_of_A_dubia_EO_on_a_5_phenyl_methyl_polysiloxane_stationary_phase_b4f398739b.jpg" alt="ACS Omega 2025, 10, 38, 44077–44086: Figure 2. GC–MS profile of A. dubia EO on a 5%-phenyl-methyl-polysiloxane stationary phase. The peak numbers refer to major compounds (≥3.0% on at least one column) in Table 1." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2025_10_38_44077_44086_Figure_2_GC_MS_profile_of_A_dubia_EO_on_a_5_phenyl_methyl_polysiloxane_stationary_phase_b4f398739b.jpg 245w," sizes="100vw" width="4123" height="1894"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2025_10_38_44077_44086_Figure_3_GC_MS_profile_of_A_dubia_EO_on_a_polyethylene_glycol_stationary_phase_f279bd70c9.jpg" alt="ACS Omega 2025, 10, 38, 44077–44086: Figure 3. GC–MS profile of A. dubia EO on a polyethylene glycol stationary phase. The peak numbers refer to major compounds (≥3.0% on at least one column) in Table 1." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2025_10_38_44077_44086_Figure_3_GC_MS_profile_of_A_dubia_EO_on_a_polyethylene_glycol_stationary_phase_f279bd70c9.jpg 245w," sizes="100vw" width="4142" height="1902"></p><h3><strong>Conclusions</strong></h3><p>The steam-distilled dry leaves of <i>A. dubia</i> produced an EO, with the non-negligible yield of 0.3% by weight. This volatile fraction was characterized by a pleasant, sweet smell, similar to the one of other sesquiterpene-based oils. Being dominated by germacrene D and due to the high enantiomeric excess of its levorotatory enantiomer, this EO could act as an attractant for the insects of the genus <i>Heliotis</i>. Despite <i>A. dubia</i> currently is an only wild species, its leaf EO could be considered commercially promising, due to its high distillation yield. Cosmeceutical science could be the main application field for this volatile fraction. In fact, the high content of limonene and (<i>E</i>)-β-caryophyllene suggested that <i>A. dubia</i> EO could present antibacterial and anti-inflammatory properties, like other oils of similar composition. Future research should experimentally investigate the biological activities of this EO, with a special focus on the two main properties deduced since literature. In fact, for cosmeceutical applications, antibacterial and anti-inflammatory capacities are possibly more interesting than other biological activities, whose actions imply a systemic mechanism instead of a topic effect.</p>

The Chemical and Enantioselective Analysis of a New Essential Oil Produced by the Native Andean Species Aiouea dubia (Kunth) Mez from Ecuador

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 6th October 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you poster by <strong>Agilent Technologies / AOAC, </strong>application notes by<strong> EST Analytical </strong>and<strong> Shimadzu </strong>and brochure by <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies / AOAC: Method Translation for the Analysis of Vanilla Extracts Using a Compact, Single Channel GC-FID and Carrier Gas Switching Module</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ps_vanilla_single_channel_gcfid_carrier_gas_aoac_2025_w020_en_agilent_17c7d568c9.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Vanilla is a flavor variety that has been heavily impacted by changes in consumer habits as well as by supply and demand of vanilla beans used to produce high-quality vanilla extracts. Unfortunately, these market conditions, increase the likelihood of adulteration in vanilla extracts by use of aroma chemicals that are not naturally occurring. Common adulterants are coumarin (C), ethyl vanillin (EV), eugenol (E), and guaiacol (G).2,3 Adulteration impacts the standard of identity for vanilla extracts established by the U.S. FDA; therefore, flavor companies rely on QC labs to implement reliable and sensitive analysis techniques for screening incoming raw ingredients against expected purity standards before the ingredient can enter a flavor formula on the manufacturing floor. Screening is typically executed with gas chromatography (GC)- based methods adapted from those used in a R&amp;D lab. However, differences in column length, diameter, and phase can make it seem challenging to harmonize GC methods across the R&amp;D and QC functions within a company due to the different analysis objectives of the respective laboratories.&nbsp;</p><h4><strong>Experimental Goals</strong></h4><ul><li>Demonstrate the ease of the Agilent Method Translator in harmonizing GC methods for multiple columns and gases&nbsp;</li><li>Establish method precision, linearity, and resolution on standards of vanilla-like adulterants using the translated methods&nbsp;</li><li>Successfully showcase the method translation using store-bought extracts to verify the integrity of the fastest GC method on samples containing matrix&nbsp;</li><li>Screen for and quantify any vanilla adulterants in the samples of vanilla extracts with the goal of detecting no adulterants using the fastest GC method.</li></ul><h4><strong>Experimental&nbsp;</strong></h4><ul><li><strong>GC System:</strong> <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8850+GC"><strong>Agilent 8850 GC</strong></a> with <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7693A+Automatic+Liquid+Sampler"><strong>7693A Automatic Liquid Sampler</strong></a></li></ul><h4><strong>Conclusions</strong></h4><h5><strong>Method Translation</strong></h5><ul><li>The method translator tool provided an easy conversion of a 50-minute-long method to one that is &lt; 5 minutes resulting in a speed gain of 10-fold and 14-fold, for He and H2 carrier gases, respectively (Figures 2 and 3)&nbsp;</li><li>Resolution of analytes were &gt;4 on the 60 m and &gt;3.5 on the 10 m DB-1 columns (Table 2)</li><li>Precision was &lt;1.85% RSD and &lt;2.5% RSD for He and H2 carrier, respectively (Table 3)</li><li>Linearity was demonstrated from 10 ppm to 100,000 ppm for He and H2 carrier with R2 ranging from 0.9997 to 1.0000&nbsp;</li></ul><h5><strong>Carrier Gas Switching</strong></h5><ul><li>He and H2 carrier gases were alternated line by line in a sequence table for increased analytical efficiency and higher throughput while demonstrating the flexibility the helium conservation module provides its users while also eliminating manual changes to plumbed gases at the GC EPC Module.</li></ul><h3><strong>2. EST Analytical: Optimizing 8260 Sample Throughput - Solutions for the Determination of Bromomethane by Purge and Trap</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Purge_and_Trap_Solutions_for_the_Determination_and_Stability_of_Bromomethane_by_P_and_T_App_Note_Rev_2_177c75d029.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The United States Environmental Protection Agency’s (USEPA) Method 8260 has an extensive list of compounds of interest. In order to purge and trap these analytes, there needs to be an analytical trap able to trap these compounds and desorb them to the Gas Chromatograph/Mass Spectrometer (GC/MS) both accurately and efficiently. Due to the broad range of compounds on the Method 8260 list, there are many issues to take into account. Purge efficiency, molecular weight, volatility, and water are among the most problematic issues. The purge and trap concentrator and analytical trap must be able to account for all of these concerns.&nbsp;</p><p>The most commonly used analytical trap is the Vocarb® 3000 due to its ability to trap and desorb the extensive analyte list both effectively and correctly. However, the Vocarb® 3000 trap is not without its drawbacks. One of which is Bromomethane degradation in the trap over time. This application will examine the Vocarb® 3000 and a custom trap along with the optimum trap temperature parameters for the stability of Bromomethane.&nbsp;</p><h4><strong>Experimental</strong></h4><p>The purge and trap concentrator used for this study was the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2160"><strong>EST Analytical Evolution</strong></a>. The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2159"><strong>Centurion Water and Soil autosampler</strong></a> equipped with the syringe option was employed as the autosampler. Separation and analysis of the volatile compounds was performed by the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=7890A"><strong>Agilent 7890A Gas Chromatograph (GC) </strong></a>and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=5977B"><strong>5977B Mass Spectrometer</strong></a> (MS). The GC was configured with a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=9&amp;search=Rxi-624+Sil+MS"><strong>Restek Rxi624 Sil MS</strong></a> 30m x 0.25mm x 1.4µm column. The purge and trap parameters and analytical traps used for this study are listed in Tables 1 and 2 while Table 3 details the GC/MS parameters.</p><h4><strong>Conclusions</strong></h4><p>Initially, all of the traps and heating parameters used in the EST Analytical Evolution met USEPA method 8260 requirements and could be used in the laboratory. However, the custom trap and the higher temperature desorb and bake showed a lower response when compared to using a lower temperature desorb and bake. Furthermore, over time, the custom trap and higher temperature desorb and bake displayed lower recoveries of Bromomethane which could in turn affect the continuing calibration standards. The Vocarb® 3000 trap with the lower temperature desorb and bake proved to be the optimum method for sampling USEPA Method 8260 compounds. The technique met all of the method requirements and exhibited the best response and stability not only for Bromomethane but also for the rest of the extensive compound list.</p><h3><strong>3. Shimadzu: Quantitative Analysis of Furan and Alkylfurans in Processed Food Using Headspace GC-MS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00906_en_878a49b98e.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Furan and alkylfurans are aromatic compounds with a fivemembered ring structure. Furan and some alkylfurans, such as 2-methylfuran, 3-methylfuran, and 2,5-methylfuran (furan with a hydrocarbon chain attached), are found in processed food. They are generated through a variety of pathways during heat treatment of the food. Some countries have studied these compounds and concluded they are a health concern. 1) At present, no country has set permissible levels for furan or alkylfurans in food. But since they are harmful substances that are generated unintentionally during the processing of food, analyzing them is becoming increasingly important. In this Application News, the levels of furan and alkylfurans in commercially available processed food were measured.</p><h4><strong>Equipment&nbsp;</strong></h4><p>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-QP2050"><strong>GCMS-QP2050</strong></a> gas chromatograph mass spectrometer has a compact design for a smaller installation footprint. When combined with the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=HS-20+NX"><strong>HS-20 NX headspace sampler</strong></a>, the GCMSQP2050 can simply and accurately measure furan and alkylfuran levels in processed food. The DuraEase ion source, which is specifically designed for durability and ease of maintenance, also providesreduced maintenance requirements.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>In this Application News, headspace GC-MS analysis was used to measure levels of furan and alkylfurans in processed food. Analysis of standard samples produced good results in terms of separation, calibration curve linearity, and repeatability. Analyzing food samples and comparing the results obtained by the external standard method and the standard addition method showed that the matrix effects differed depending on the sample.</p><h3><strong>4. Thermo Fisher Scientific: Everything You Need in a GC Detector: VGA-100 Gas Chromatography Detector for TRACE 1600 Series GC</strong></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/br_003592_gc_vuv_detector_vga_100_isomers_br003592_na_en_0a48830aff.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>Performance synergy—the VGA-100 detector and the </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/483"><strong>TRACE 1600 Series GC</strong></a><strong>&nbsp;</strong></h4><p>VUV absorbance and gas chromatography offer a perfect match, joining insights on light absorption in the VUV range with each compound’s unique gas phase absorption features. The innovative VUV absorption technology of the VGA-100, combined with the robust and reliable performance of the Thermo Scientific™ TRACE™ 1600 Series gas chromatograph, offers a powerful analytical solution to support timecritical laboratory demands.&nbsp;</p><p>Harnessing breakthrough gas chromatography technology, VGA-100 provides unmatched precision and data quality with faster results and higher sample volume. Experience analytical insights with a system designed for ease of use that delivers accurate, reportable results across a diverse range of industries.</p><h4><strong>Explore the benefits of VUV technology&nbsp;</strong></h4><p>The unique capabilities of the VGA-100 detector for the TRACE 1600 Series GC help solve common challenges, such as correct isomer identification, poor selectivity, long method run times, analyte co-elution, burdensome data processing and analysis, and method scalability to production environments.&nbsp;</p><h5><strong>Expand detectable compounds.&nbsp;</strong></h5><p>Access to a wider range of analytes with enhanced sensitivity towards impurities as well as accurate sample profiling, thanks to the combined universal and selective response of the VGA-100 detector.&nbsp;</p><h5><strong>Unambiguous identification.&nbsp;</strong></h5><p>The VGA-100 universal mass-sensitive detector delivers comprehensive data for robust analysis. Data provided in 3D (time, wavelengths, and intensity) supports reliable identification through spectra that can be matched to a dedicated library, including isomers discrimination.&nbsp;</p><h5><strong>Ease of use and maintenance.&nbsp;</strong></h5><p>Robust and easy to set up and operate, the VGA‑100 requires minimal maintenance, with no vacuum pumps required. An intuitive design supports high demands for throughput and compliance, supporting the needs of both research and quality control laboratories.&nbsp;</p><h5><strong>Faster analysis.&nbsp;</strong></h5><p>Obtain rapid and accurate results with the advanced capabilities of VUV technology, complemented by the fast and efficient chromatographic separation of the TRACE 1600 Series GC.&nbsp;</p><h5><strong>VUV Analyze Software for push-button simplicity&nbsp;</strong></h5><p>The advanced post-acquisition processing capabilities of VUV Analyze™ Software (VUV Analytics, Inc.) allows laboratories to generate meaningful results with just the push of a button. This cutting-edge software platform swiftly analyzes complex chromatographic and spectral data, delivering method-specific results and reports. By automating the analysis process, VUV Analyze Software significantly streamlines and speeds up each run while minimizing errors, leading to greater confidence in results.</p>

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News from LabRulezGCMS Library - Week 41, 2025

The Chemical and Enantioselective Analysis of a New Essential Oil Produced by the Native Andean Species Aiouea dubia (Kunth) Mez from Ecuador

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Flavor Characteristics of Different Varieties of Flue-Cured Tobacco Based on Headspace Gas Chromatography–Ion Mobility Spectrometry and Headspace Solid-Phase Microextraction–Gas Chromatography–Mass Spectrometry

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