In this technical tip from Phenomenex, the topic of gas chromatography (GC) column trimming is addressed from a troubleshooting perspective. The key question explored is whether trimming a GC column is necessary and how it impacts chromatographic performance.<h3>Why Trim a GC Column?</h3>Column trimming is primarily used to restore chromatographic performance by removing damaged or contaminated sections, typically located at the column inlet.<h5>1. Baseline Bleed, Noise, Ghost Peaks, Poor Peak Shape</h5><ul><li>Cause: Column contamination</li><li>Removing the contaminated stationary phase at the column entrance helps restore performance.</li></ul><h5>2. Elevated Baseline (Especially at High Temperature)</h5><ul><li>Cause: Column bleed</li><li>Degradation of the stationary phase due to oxygen exposure or thermal damage leads to increased baseline.</li></ul><h5>3. Ghost Peaks (Peaks Without Injection)</h5><ul><li>Cause: Residual sample or contamination</li><li>Compounds trapped at the beginning of the column can appear as peaks even when no sample is injected.</li></ul><h5>4. Peak Tailing (Asymmetrical Peaks)</h5><ul><li>Cause: Damaged or contaminated column sections</li><li>These issues result in adsorption effects or poor flow dynamics.</li></ul><h5>5. Retention Time Shifts</h5><ul><li>Cause: Contamination or damage near the inlet</li><li>Although trimming slightly changes retention time, it can correct shifts caused by inlet-side issues.</li></ul><h5>6. Baseline Noise and Spikes</h5><ul><li>Cause: Particulate matter or degraded stationary phase</li><li>These can lead to detector instability and random signal fluctuations.</li></ul><h5>7. Baseline Drift or Wander</h5><ul><li>Cause: Contamination or oxidized column sections</li><li>Removing these regions stabilizes the baseline.</li></ul><h5>8. Loss of Resolution or Sensitivity</h5><ul><li>Cause: General column degradation</li><li>Trimming removes the most exposed and damaged portions, effectively rejuvenating column performance.</li></ul><h3>How to Trim a GC Column</h3>A capillary GC column consists of:<ul><li>Polyimide outer coating (protective layer)</li><li>Fused silica tubing (fragile but flexible core)</li></ul><h3>Step-by-Step Procedure</h3><h5>1. Scoring the Column</h5><ul><li>Use a ceramic wafer</li><li>Hold it at an inclined angle</li><li>Score the polyimide coating perpendicular to the column</li></ul><h5>2. Breaking the Column</h5><ul><li>Perform a quick, decisive flick</li><li>This ensures a clean, square cut</li></ul><h5>3. Inspecting the Cut</h5>After trimming, visually inspect the column end.<h3>Examples of Column Cuts</h3><h4>Good Cut</h4><ul><li>Clean, square end</li><li>Ensures proper sealing and connection</li></ul><h5>Bad Cuts</h5><ul><li>Slight Irregularity<ul><li>Small imperfection at the edge</li><li>Can cause leaks and active sites</li></ul></li><li>Poor / Rough Cuts<ul><li>Uneven or jagged edges</li><li>Lead to:<ul><li>Poor connections</li><li>Active sites</li><li>Peak tailing</li></ul></li></ul></li></ul><h2>Conclusion</h2>Trimming a GC column is a simple yet effective troubleshooting step. By removing contaminated or damaged sections—especially near the inlet—it can resolve a wide range of chromatographic issues, including baseline instability, ghost peaks, and loss of performance.Proper cutting technique is essential to avoid introducing new problems such as leaks or active sites.

Trimming a GC Column: Purpose, Symptoms, and Proper Technique

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 30th March 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies, Thermo Fisher Scientific, brochure by Shimadzu and presentation by MDCW / LECO!<h3>1. Agilent Technologies: Extraction and Analysis of Pesticides from Water by Solid Phase Extraction and GC/MS</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_extraction_analysis_pesticides_water_gcms_5994_8996en_agilent_28fc35d0e7.pdf">Full PDF for download</a></li></ul>Drinking water is defined as water intended for human consumption obtained from different sources. Several guidelines/regulations exist for ensuring that undesirable substances such as pesticides are not present in excessive amounts that may be harmful to human health. These regulations ensure that water intended for human consumption can be consumed safely. In India, the Bureau of Indian Standards (BIS) has set regulatory limits for residual pesticides in drinking water (IS 10500)1 , packaged drinking water (IS 14543)2 , and natural mineral water (IS 13428).3 A total of 26 pesticides are regulated by BIS standards, of which four compounds (monocrotophos, phorate, 2,4-D, and isoproturon) are more suitable for analysis by liquid chromatography.&nbsp;EPA Method 525.2 is a general-purpose method for determination of organic compounds in finished drinking water or water from any source or treatment stage.4 This method is applicable to a range of organic compounds that are partitioned from the water sample onto a C18 organic phase packed in a disk or cartridge. The organic compounds are then eluted using a suitable eluent, concentrated, and analyzed by GC/MS.&nbsp;This application note describes the use of EPA Method 525.2 for extraction of pesticide residues at trace levels in water using solid-phase extraction (Agilent Bond Elut C18: Straight barrel cartridges, p/n 12102118) and analysis using Agilent 8890-5977 GC/MS.&nbsp;Excellent linearity with R2 &gt; 0.995 was obtained for all pesticides considered for the study. Recoveries were obtained in the range of 80–120% with associated RSDs &lt; 15% at 0.005–0.080 ng/mL level of fortification.<h4>Experimental</h4><h5>Instrument parameters</h5><ul><li>GC: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=8890">Agilent 8890</a></li><li>Column: Agilent <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=J%26W+HP-5ms">J&amp;W HP-5ms</a> UI 30 m × 0.25 mm, 0.25 μm&nbsp;</li><li>Carrier Gas: Helium, constant flow, 1.2 mL/min&nbsp;</li><li>Inlet: Agilent Multimode Inlet (MMI)</li><li>MS: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=5977">5977 GC/MS</a></li></ul><h4>Conclusion&nbsp;</h4>A simple, easy, and efficient method based on EPA 525.2 was implemented for the determination of 22 pesticides in water. The method demonstrated good sensitivity, precision, and accuracy, and allows for rapid analysis. The results demonstrate that pesticide residues can be detected below the current maximum residue levels (MRL) required by the BIS specifications. Acceptable recoveries and precision were obtained at concentrations as low as 5 ng/L for all pesticides. The method is ideally suited for use in a regulatory laboratory for the determination of pesticides in surface, drinking, and packaged drinking water.<h3>2. MDCW / LECO: Exploring PFAS in Consumer Goods Using GCxGC and High-Resolution Mass Spectrometry</h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_3_Alonso_6f61e3ea43.pdf">Full PDF for download</a></li></ul>Per- and polyfluoroalkyl substances (PFAS) are widely used in consumer and industrial products due to their unique physicochemical properties, but their persistence and potential health risks have made their detection increasingly important. This study focuses on developing an untargeted analytical approach for screening PFAS and related compounds in consumer goods using advanced chromatographic and mass spectrometric techniques.The analytical workflow combines gas chromatography with time-of-flight mass spectrometry (GC-TOFMS) and comprehensive two-dimensional gas chromatography coupled with high-resolution TOFMS (GC×GC-HRTOFMS), using systems such as the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1097">LECO Pegasus® BTX </a>and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/38">Pegasus® HRT+</a> platforms. Sample introduction is performed via thermal desorption or pyrolysis, enabling analysis of both volatile and complex matrices. High-resolution MS provides accurate mass measurements and elemental composition, which are essential for identifying unknown compounds and reducing matrix interferences.In the first case study, anti-fog solutions were analyzed and found to contain a wide range of compounds, including fluorotelomer alcohols and related PFAS species. While GC-TOFMS enabled initial screening, high-resolution TOFMS was necessary to characterize unknown compounds through accurate mass determination and complementary ionization techniques (EI and PCI). This approach allowed tentative structural assignment using external databases, demonstrating the importance of HRMS in identifying compounds not present in standard libraries.The second case study focused on chewing gum, a highly complex matrix with diverse chemical constituents and trace-level analytes. The use of GC×GC-HRTOFMS significantly improved chromatographic separation and spectral clarity, enabling detailed profiling of volatile and semi-volatile compounds. A dedicated PFAS screening workflow based on mass defect analysis and spectral filtering was applied, leveraging the characteristic CF₂ patterns of PFAS molecules to simplify data interpretation.Despite the complexity of the sample, no PFAS were detected in the chewing gum, its packaging, or the box. Overall, the study demonstrates that combining GC×GC separation, high-resolution mass spectrometry, and advanced data processing tools provides a powerful and reliable strategy for untargeted PFAS screening in complex consumer products, particularly when unknown or emerging contaminants are of concern.<h3>3. Shimadzu: Gas Chromatograph Nexis GC-2060</h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c184_e056_06c3456516.pdf">Full PDF for download</a></li></ul>The Shimadzu <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=Nexis+GC-2060">Nexis GC-2060</a> represents a new generation of gas chromatographs, built on over 70 years of GC development and designed to serve as a flexible and future-proof analytical platform. It integrates the concept of Analytical Intelligence, which enables automated system monitoring, troubleshooting, and optimization, helping both experienced and less experienced users achieve reliable and consistent results. The system is highly configurable, supporting up to two injectors, three injection units, and four detectors simultaneously, allowing a single instrument to cover multiple analytical applications.A key advantage of the Nexis GC-2060 is its versatility in sample introduction and detection. The Multi-Mode Injection Unit (MMI) supports a wide range of injection techniques, including split/splitless, PTV, direct injection, large-volume injection (LVI), and thermal desorption, significantly reducing the need for complex sample preparation. The system is also equipped with next-generation detectors such as FID and TCD, offering high sensitivity, stability, and linearity, with additional detector options (ECD, FPD, FTD, BID) enabling broad application coverage.The instrument is designed to maximize laboratory efficiency and minimize downtime. Features such as tool-free column installation (ClickTek), automated startup/shutdown, Easy sTop maintenance mode, and Clean Pilot for automated column conditioning simplify routine operation and reduce manual intervention. In addition, Eco Idling technology automatically optimizes gas and power consumption during standby, significantly lowering operational costs while maintaining readiness for analysis.From an analytical performance perspective, the Nexis GC-2060 delivers excellent reproducibility and sensitivity, supported by advanced autosamplers (e.g., AOC-30) and compatibility with third-party systems. The platform supports hydrogen carrier gas for faster analysis and includes smart gas management features such as automatic gas switching. Its modular design allows seamless integration with various sample preparation systems, autosamplers, and detectors, ensuring adaptability to evolving laboratory needs.Overall, the Nexis GC-2060 combines high performance, operational efficiency, and flexibility in a single platform, making it suitable for a wide range of applications, including pharmaceutical analysis, environmental testing, food analysis, and energy-related measurements. Its scalability and continuous software updates ensure long-term usability and alignment with future analytical requirements.<h3>4. Thermo Fisher Scientific: Accurate multi-component blast furnace gas analysis maximizes iron production and minimizes coke consumption</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/epm_AN_Iron_Production_Prima_PRO_bd5de98b44.pdf">Full PDF for download</a></li></ul>Over a billion tonnes of iron a year are produced in blast furnaces, representing around 94% of global iron production¹. The blast furnace consists of a large steel stack, lined with refractory brick. Iron ore, coke and limestone are dropped into the top of the furnace and preheated air blown into the bottom through nozzles called ‘Tuyeres’. Iron oxides are reduced in the melting zone, or ‘Bosh’, forming liquid iron (called ‘hot metal’) and liquid slag. These liquid products are drained from the furnace at regular intervals, and the blast furnace will run continuously for several years, until the refractory lining needs replacing.Analysis of carbon monoxide (CO) and carbon dioxide (CO₂) give vital information on the efficiency of the reduction processes. Historically, two non-dispersive infrared (NDIR) analyzers were used, one to measure CO, the other CO₂. Additional discrete analyzers were required to monitor oxygen and hydrogen – typically paramagnetic O₂ analyzers and thermal conductivity analyzers for H₂.&nbsp;Thermo Scientific™ process mass spectrometers have been widely used for many years for key gas analysis applications in iron and steel plants, including blast furnace, basic oxygen steelmaking, coke oven gas analysis, secondary steel process control, fuel gas analysis and direct reduction iron processes²<h4>Process control requirements&nbsp;</h4>The advantages of process MS over conventional analysis techniques have been proven over many years in the iron and steel industry. The ability to measure a wide range of components on a single analyzer, coupled with advanced calibration, data transmission, and self-diagnostic software, makes the modern mass spectrometer ideal for integration into the modern plant. On blast furnaces, superior gas analysis is being used to calculate gas efficiency, mass and heat balances, and heat profiles through probe analysis, as well as being an essential tool in the early detection of cooling water leaks and sample system failures.&nbsp;Figure 2 shows 64 hours of data from a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2305">Thermo Scientific™ Prima™ PRO Process MS</a> monitoring the six gases in a blast furnace top gas every 10 seconds. The pulse every 12 hours is generated by an automatic nitrogen blowback from the sample conditioning system, to keep the sample probe clear of particulates.<h4>Hydrogen analysis&nbsp;</h4>An increase in the hydrogen level in the furnace can indicate a leak from the furnace cooling system, as water dissociates into hydrogen and oxygen in the furnace. This has implications both for plant efficiency and plant safety. Water leaks will lower the furnace temperature, causing heat loss and a consequent increase in fuel consumption. In extreme cases, damage to plant and personnel can be caused by ignition of these hazardous mixtures of explosive gases.&nbsp;Figure 4 shows a plot of top gas hydrogen concentration measured by Thermo Scientific process MS over a 24-hour period, with the departure of the measured H2 value from that predicted by the mass balance model indicating a water leak. This leak was caused by the failure of a cooling member, and the furnace was taken off blast for repair. The mass spectrometer’s ability to provide fast, accurate hydrogen analysis removes the need for an additional discrete analyzer.&nbsp;Gas composition measurement is particularly important during the end-of-campaign blowdown that takes place prior to rebuilds and relines, because explosive gas mixtures can be generated.&nbsp;<h4>Probe analysis&nbsp;</h4>The fast analysis provided by MS offers another significant advantage over discrete analyzers—a number of process streams can be analyzed using a single instrument. This is achieved using a fully automated multi-inlet system, designed to switch between sample streams at high speeds with minimal sample flushing times. For example, as well as furnace top gas, the MS can also analyze gases from probes placed above and below the burden (the furnace charge of iron ore, coke and limestone). These are known as above-burden and sub-burden probes and provide valuable information on fuel efficiency, iron conversion and furnace charging. Figure 5 shows a schematic of these two probes; they can be moved across the furnace to build a cross-sectional profile of the furnace.<h4>Summary&nbsp;</h4>Thermo Scientific process mass spectrometers have been successfully monitoring blast furnace off gas at many of the world’s iron and steel companies for over 30 years. For a blast furnace producing 5,000 tonnes a day, a reduction in coke consumption of just 10 kg per tonne of iron produced provides a payback of over $10,000 a day. Users report that the combination of fast, accurate MS gas analysis for gas efficiency, heat and mass balances and hydrogen analysis, with advanced process control and mathematical modeling, has reduced coke consumption by up to 100 kg per tonne and increased iron production. Upgrading to Prima PRO MS can therefore result in complete installation payback within a few weeks.&nbsp;<ul><li>Reduces coke consumption&nbsp;</li><li>Produces consistent quality iron&nbsp;</li><li>Reduces downstream processing costs&nbsp;</li><li>Detects water leaks fast&nbsp;</li><li>Improves thermal control of furnace&nbsp;</li><li>Enables safer operation during blowdown</li></ul>

News from LabRulezGCMS Library - Week 14, 2026

<h3>We're excited to announce that <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity Chromatography Software</a> version 10.1.2 is now available!</h3>This minor update expands Clarity’s portfolio with new control modules.<h4>Newly added Instrument control modules</h4><ul><li>Ecom auxiliary modules</li><li>HTA ICF control modules</li><li>Spark pump</li></ul><h4>Updated Instrument control modules</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/168">Ecom</a> HPLC</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/328">Knauer</a> HPLC</li><li>Spark ICF control modules</li><li>YoungIn Chromass HPLC</li></ul><blockquote>For a complete list of module changes, see the <a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1">Changelog</a>. For more info about exciting new features directly in Clarity, explore what was introduced in the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5622">Clarity 10.1 release highlights</a>.Clarity can control 1000+ instruments; the <a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/controls">list can be previewed here</a>.</blockquote><h4>Supported Instruments in Clarity (DataApex) — Quick Guide</h4>Clarity Chromatography Software supports a wide range of chromatographs and peripherals via digital control (DD) and analog acquisition (A/D) using the Colibrick module.<h5>Gas Chromatographs (GC)</h5>Digital integration over LAN/RS232 (many via ICF):<ul><li>Agilent: 5890, 6890, 7890, 8860, 8890, Intuvo 9000</li><li>Shimadzu: GC-2010/2014, Nexis GC-2030</li><li>Thermo Fisher: TRACE 1300/1310</li><li>PerkinElmer: Clarus 400–690</li><li>Also supported: Dani, Ellutia, Young In Chromass, Apix, Fuli, GOW-MAC (selected models)</li></ul><blockquote>Note: Most Agilent 6890–8890 and Intuvo use LAN – ICF.</blockquote><h5>HPLC Systems</h5>Full system/module control:<ul><li>Agilent 1100–1290 Infinity II (ICF)</li><li>Shimadzu LC-10/20 and Nexera LC-40</li><li>PerkinElmer Flexar / NexSAR</li><li>Knauer Azura / BlueShadow / Smartline</li><li>Hitachi Chromaster / Primaide</li><li>Young In Chromass ChroZen series</li><li>Sykam S500–S600, Watrex Streamline, Hanon LC7000–7300</li></ul><h5>HPLC Modules (Pumps, Detectors, Ovens, Fraction Collectors)</h5><ul><li>Pumps: Agilent 1100–1290 families, Knauer, Shimadzu, PerkinElmer, Sykam, SSI, Ecom</li><li>Detectors: VWD/DAD(PDA)/RID/FLD/ELSD across Agilent, Shimadzu, Knauer, PerkinElmer, Young In Chromass, Ecom, etc.</li><li>Column Ovens: Agilent G1316x / G7116x, Shimadzu CTO-20/30/40, Knauer CT2.1, PerkinElmer Flexar</li><li>Fraction Collectors: Knauer FC 6.1, Teledyne FOXY series, Ecom ECF 2096, Waters Fraction Collector II</li></ul><h5>Autosamplers</h5><ul><li>Agilent GC ALS (7673/7683/7693/8697), HPLC ALS modules (G1313A–G7167C)</li><li>Shimadzu AOC-20 / AOC-5000+, SIL-10 / SIL-20 / SIL-40 series</li><li>CTC Analytics PAL, HTA autosamplers, Spark Alias/UHPLC, Knauer AS 6.1L</li><li>PerkinElmer Flexar / NexSAR AS</li></ul><h5>Other Devices</h5><ul><li>GC×GC modulators (e.g., Charles University GC×GC Modulator)</li><li>Valves &amp; switch modules (Agilent, Knauer, Shimadzu, VICI-Valco)</li><li>Degassers, flow monitors, managers, interfaces</li><li>LC-MS / GC-MS: Advion Expression CMS, Microsaic 4500 MiD, Markes BenchTOF (and others)</li><li>Balances (EA extension): Mettler Toledo, Sartorius</li></ul><h5>Analog Acquisition (Colibrick)</h5>A/D support for legacy or analog-output devices:<ul><li>GC: Agilent 5880/4890A, Varian 3xxx/3800/3900, PerkinElmer Clarus series, Thermo TRACE, Shimadzu GC-14/9A, Scion 43x/45x/83xx/85xx, etc.</li><li>HPLC Detectors: Waters 2487/2489, ESA Corona, Hitachi L-series, JASCO FP/UV, Ecom LCD series, many others</li><li>Elemental &amp; Amino Acid Analyzers: Carlo Erba/Costech ECS, Biochrom 20/30+</li></ul>If you are interested in a DEMO VERSION, contact us!

DataApex Clarity Chromatography software 10.1.2 just released!

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Join our upcoming webinar on the MassHunter Quant Screener Tool to discover how to harness the power of quantitative analysis for effective screening and identification of potential suspect compounds.This session will provide in-depth guidance on creating methods from PCDL databases, evaluating result parameters, and generating straightforward summary reports. Additionally, learn how retention time (RT) prediction can enhance your screening process by significantly accelerating and simplifying large database searches.Don’t miss this opportunity to elevate your analytical capabilities!<blockquote>Presenter: &nbsp;Jonathan Spencer (Application Specialist, Agilent Technologies)Jonathan studied BSc Natural Sciences at the University of Nottingham and later went on to Sheffield Hallam University to study a MSc in Forensic Science.Following graduation, he spent 2 years as a Confirmatory Analyst in an anti-doping and forensic toxicology lab, before joining Agilent as an LC/MS Applications Scientist. At Agilent, he focuses on small molecule applications using LC/TQ and LC/Q-TOF in fields of like food, forensic and environmental analysis.</blockquote>

Agilent Technologies: MassHunter Masterclass Months

MassHunter Quant Screener Tool

Discover how to harness the power of quantitative analysis for effective screening and identification of potential suspect compounds. 

Join us on the hunt for the needle in the haystack!This session will delve into best practices for untargeted feature finding, focusing on achieving the optimal balance between sample coverage and processing speed using Profinder and the new MassHunter Explorer. We will explore techniques to differentiate between features and noise by applying the right filters for quality checking your data. Additionally, the webinar will cover essential aspects of compound identification, including database matching, formula generation, and structure elucidation.This is a must-attend event for anyone looking to enhance their analytical capabilities and streamline their data processing workflows.<blockquote>Presenter: &nbsp;Stefan Schaebler (Application Specialist LC/MS, Agilent Technologies)Stefan completed his PhD in Biology, specializing in LC-MS-based lipidomics and metabolomics. Following his doctoral studies, he joined Agilent Technologies as an LC/MS Application Specialist. In this role, Stefan focuses on small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</blockquote>

Finding the Needle in the Haystack Part I: From Complex Samples to Compounds of Interest

The best practices for untargeted feature finding, focusing on achieving the optimal balance between sample coverage and processing speed.

From Complex Samples to Compounds of Interest

The hunt goes on, let's find the needle in the haystack:Join us for an insightful webinar where we delve into the world of chemometrics to enhance your data interpretation skills. Learn how to select the appropriate statistical tools to make sense of your data and identify features of interest by visualizing trends and changes using various clustering and grouping approaches. We will also cover the construction of class prediction models to differentiate between sample cohorts effectively.Finally, gain a deeper understanding of your findings by mapping them onto relevant metabolomic pathways, providing essential context for your research.<blockquote>Presenter: Hannah Florance (Application Specialist LC/MS, Agilent Technologies)Hannah has had multiple roles in the life sciences, starting as a protein chemist, before moving into proteomics and then metabolomics. A major part of her time working in academia involved running LC and GCMS core facilities supporting projects ranging from synthetic biology to cancer research. She is currently an LCMS applications specialist for Agilent. Presenter: Shaun Reeksting (Application Specialist LC/MS, Agilent Technologies)Shaun completed his PhD in Biochemistry, specializing in molecular parasitology a focus in metabolomics. Following his doctoral studies, he worked in accredited industry laboratories and academia core-facilities before joining Agilent Technologies as an LC/MS Application Engineer.In this role, Shaun focuses on environmental small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</blockquote>

Finding the Needle in the Haystack Part II; All Things Chemometric

Join us for an insightful webinar where we delve into the world of chemometrics to enhance your data interpretation skills.

All Things Chemometric

In our last session, we will tackle compliance as we will delve into the critical aspects of compliance and its significance for your laboratory.Discover what compliance entails and why it is essential for maintaining the integrity and reliability of your lab’s operations. We will explore the various configurations available to meet your specific regulatory requirements, ensuring you have the necessary tools and knowledge to stay compliant.Additionally, gain valuable insights into content management, audit trails, and applications that streamline your compliance processes, making your lab more efficient and secure.Don’t miss this opportunity to enhance your understanding of working in a regulated environment and ensure your lab’s success.<blockquote>Presenter: &nbsp;Christian Hegmanns (Application Specialist LC/MS, Agilent Technologies, Waldbronn, Germany.)Christian Hegmanns is a state-certified food chemist and works at Agilent as an LC/MS application specialist.With over 10 years of experience in the field of instrumental analysis, Christian develops customer-oriented solutions for a variety of applications with a focus on food analysis.</blockquote>

MassHunter Compliance – Working in a Regulated Environment

We will tackle compliance as we will delve into the critical aspects of compliance and its significance for your laboratory.

<div><div><div>Conventional GC-HRMS using EI data alone for non-target studies suffers from ambiguous identification of unknowns in NIST library searches due to less specific fragmentation, missing molecular ion signals or compound absence in the reference library. Library searches become prone for false positive assignment. To increase compound identification certainty, the addition of the molecular information, e.g., via CI is mandatory.See how a novel GC-HRMS approach with simultaneous EI and CI data acquisition in a single GC run dramatically improves the quality of information and identification certainty. Non-target studies in wastewater analysis, human metabolites, vegan food similarity and material emission prove a game-changing power of the system.Why to join this webinar:<ul><li>Understand the power of simultaneous EI and CI-HRMS data in single GC runs</li><li>Learn how to get to a safe and confident identification of unknowns in suspect and non-target GC-MS</li><li>Get to know a novel CI source with unmatched performance due to a wide selection of reagent ions and “zero” instrument downtime&nbsp;</li><li>Accelerate your analysis and post-processing time plus optimize your instrument uptime with no need of hardware switching</li></ul><blockquote>Presenter: Arnd Ingendoh (VP Business Development Applied Markets, Bruker Daltonics GmbH &amp; Co KG)Arnd Ingendoh received his PhD in biophysics 1994 in the group of Franz Hillenkamp and Michael Karas who developed and invented MALDI. Following two years at ThermoFisher and Bruker in Japan and the USA as an application specialist, he moved through various management positions at Bruker Daltonics in Germany with +15 years of service as Senior Vice President for Commercial Operations EMEA.After 25 years at Bruker, he changed to a start-up company from New Zealand, Syft Technologies, to build the European commercial organization as the Vice President Europe for real-time mass spectrometry applications like air monitoring, food quality testing and monitoring of industrial processes. In 2023, he rejoined Bruker as the VP Business Development for the Applied Mass Spectrometry division. His goal is to develop and introduce novel and potentially disruptive technologies for the applied markets. Aside of his commercial activities, Arnd had active roles in academic education, e.g. as a Guest Professor at the University of Vienna. He is author or co-author of more than 60 publications.Presenter: Sonja Klee (Produkt Manager ecTOF, TOFWERK AG)Dr. Sonja Klee is Product Manager at TOFWERK, a leading mass spectrometer manufacturer based in Switzerland. Her journey in mass spectrometry began during her undergraduate studies in Chemistry at the University of Wuppertal, Germany, where she delved into ionization and mass spectrometry fundamentals in the group of Thorsten Benter. Both fundamental research and practical applications continued through her academic studies with her PhD in Physical Chemistry in 2014 on chemical ionization mechanisms in mass spectrometry for which she received the Wolfgang-Paul-Study Award of the German Society for Mass Spectrometry (DGMS). Following this, Dr. Klee was awarded a Postdoctoral Marie Curie Fellowship to contribute to the CLOUD TRAIN Network at CERN, Switzerland.Focus of this tenure was conducting complex experiments within the EU research program "CLOUD" utilizing various TOFWERK mass spectrometers. After her two-year postdoctoral position, she continued with TOFWERK, leveraging her expertise in ionization and mass spectrometry development in several key roles, including Leading Coordinator for Ion Source Technology and Project Manager. Dr. Klee's extensive research background and industrial experience have significantly contributed to the development and introduction of the ecTOF product line, a breakthrough solution for GC-MS based compound identification. Recognized for her expertise and leadership in the field, Dr. Klee was elected as an official board member of the Swiss Group for Mass Spectrometry (SGMS) in 2023. Here, she manages the "Education" portfolio, reflecting her commitment to advancing knowledge and innovation in mass spectrometry.</blockquote></div></div></div>

Bruker: Removing Barriers in Non-target GC/MS for the Confident Identification of Unknowns

Removing Barriers in Non-target GC/MS for the Confident Identification of Unknowns

Podívejte se, jak nový přístup GC-HRMS se současným sběrem dat EI a CI v jediném GC cyklu výrazně zlepšuje kvalitu informací a jistotu identifikace.

Non-target GC/MS for the Identification of Unknowns

Following the success of our last Ask the Expert session, we’re back with a part 2 focusing on GC and GC/MS workflows. This time, our panel is discussing your questions on maintenance, troubleshooting, and column care. Whether you’re aiming to improve accuracy, solve recurring issues, maximize productivity, and extend the life of your GC or GC/MS system, this session is for you. Our expert panel will address key challenges and share best practices, tips, and tricks to keep your GC/GCMS in peak condition while answering your burning questions.Key Topics:<ul><li>How to maintain your GC/GCMS for optimal performance</li><li>Troubleshooting common issues in GC and GC/MS</li><li>Best practices for column care and extending your column’s life</li><li>Tips for improving accuracy and reproducibility in results</li><li>How to ensure efficiency and productivity across your workflows</li></ul>Who Should Attend:<ul><li>Lab managers, analysts, and technicians using GC or GC/MS</li><li>Anyone looking to optimize their GC workflows for long-term performance</li></ul><blockquote>Presenter: Dr. Anshu Kumari Singh (Technical Support Manager, Agilent Technologies)Dr. Anshu Kumari Singh is the Technical Support Manager for India in the Chemistries and Supplies Division. She has more than 20 years of experience in this industry. She is leading a team of highly qualified Individuals responsible for providing technical support to customers. She provides support to customers on queries related to applications, products and troubleshooting for GC and LC columns and Supplies. She also conducts workshops, trainings and seminars for the customers helping them in understanding the chemistry behind GC &amp; HPLC columns and Sample Preparation Products. Dr. Anshu holds a Doctorate degree from Indian Agricultural Research Institute, New Delhi and is based out of Delhi.Presenter:&nbsp; Mr. Praveen Arya (Application Engineer - GC/MS, Agilent Technologies)Praveen Arya, Application Engineer at Agilent technologies, has a commitment and appreciation for Gas-phase residue applications. In 2005, Mr. Praveen Arya completed his M.Sc. in Food Technology . After post-graduation, he served as a Senior Analyst at SGS, Gurgaon- a commercial testing laboratory for 6 years and developed expertise in Residue analysis using sophisticated chromatographic instruments such as LCMS and GCMS. After that, in 2011, He joined Agilent Technologies as an Application Engineer where he supported country-wide GCMS customers for resolving application issues and method development. He has more than 18 years of experience in residue analysis in food and environmental samples using various high end chromatographic and spectrometric techniques (GC, GCMS, GCMS/MS, TDS, Headspace, Purge &amp; trap etc.). His area of specialization includes new analytical method development and validation as per national and international guidelines.Presenter:&nbsp; Mr. Anuraj Kumar (Customer Application Engineer - GC/GCMS, Agilent Technologies)Anuraj has overall 10+ years of experience in handling Gas Phase products. Working with Agilent since 4+ years and looking for GC &amp; GCMS products as core Post Sales application engineer for PAN India. Previously he had worked with multiple pharmaceutical R&amp;D as an Research Scientist in Teva, Fresenius kabi &amp; Jubilant Life Sciences.Presenter:&nbsp; Mr. Sunil B Lakhmapure (Technical Support Specialist, Agilent Technologies)Sunil holds 19 year plus experience in the analytical field with major exposure to LC/GC with Single Quad, Triple Quad and high resolution (QToF) mass spectroscopy. Started career in Pharma R&amp;D as a scientist with hands on experience on high end instruments like LC/MS, XRD &amp; NMR. Developed &amp; published application notes using Chromatographic techniques on real world samples/issues at various levels.</blockquote>

Agilent: Decoding GC & GC/MS: Maintenance, Troubleshooting, and Best Practices

Decoding GC & GC/MS: Maintenance, Troubleshooting, and Best Practices

Challenges, best practices, tips, and tricks to keep your GC/GCMS in peak condition.

GC & GC/MS: Maintenance, Troubleshooting, Best Practices

With the need for risk assessment and testing plans looming on the horizon, join us to learn about the challenges of low-level nitrosamine detection for both LCMS and GCMS applications.We will explore the pressing questions of coming regulation, including guidance on NDSRIs, the differing use cases of the 4 Procedures of USP &lt;1469&gt; and how Shimadzu can be your partner in creating solutions to meet these requirements.As you prepare for the August 1, 2025 deadline, whether your needs will be nitrosamine discovery with LCMS-QTOF or high-sensitivity QC monitoring with headspace GC-MS/MS, Shimadzu has the hardware and applications to help you succeed.We will host a Q&amp;A session after the presentation to address any questions or comments.<blockquote>Presenter: Brian Domanski (Strategic Collaboration Scientist, Shimadzu Scientific Instruments)Brian has over 10 years working to provide LC and SFC solutions for Pharma, as well as experience with a wide range of chromatography techniques including RP, NP, HILIC, IEX, SEC/GPC, and IC. His focus also includes scalable Informatics and Data Integrity solutions.</blockquote>

Shimadzu: Are you Nitrosamine Ready? Solutions for Nitrosamine Analysis

Are you Nitrosamine Ready? Solutions for Nitrosamine Analysis

Join us to learn about the challenges of low-level nitrosamine detection for both LCMS and GCMS applications.

Solutions for Nitrosamine Analysis by LCMS and GCMS

<div pardot-region="webinar-information" pardot-region-type="pardot" id="description" data-id="30577" data-hml-enabled="1">LECO will regularly invite key leaders of the NTS space from all industries to present and discuss their groundbreaking work. This series promises not only to delve deeper into the intricacies of non-targeted screening but also to foster collaboration and knowledge exchange among experts and enthusiasts alike.Secure your spot now and embark on a journey of discovery in chemical analysis, with each instalments of our monthly webinar series delivering fresh perspectives and invaluable insights.Dr. Levermore will explore the composition of ambient particulate matter and its implications for occupational health, using advanced mass spectrometry techniques to uncover the sources and characteristics of airborne particles in various work environments.Don't miss this opportunity to gain valuable knowledge from an expert in environmental analysis.&nbsp;</div><div pardot-region="speaker-information" pardot-region-type="pardot" id="speakers" data-id="30580" data-hml-enabled="1"><div><div>Presenter: Dr.Joseph Levermore (Imperial College, London)Joining us from Imperial College London, Dr. Joseph Levermore will present his research on 'What is in Our Air? High-Resolution and Comprehensive Mass Spectrometry Analysis of Ambient Particulate Matter in Occupational Environments Across the United Kingdom.' Dr. Levermore will explore the composition of ambient particulate matter and its implications for occupational health, utilizing advanced mass spectrometry techniques to uncover the sources and characteristics of airborne particles in various work environments. He will highlight the critical importance of understanding air quality for worker safety and public health, providing valuable insights into the air we breathe.</div></div></div>

LECO: Environmental Non-Targeted Screening: What is in our Air? High-Resolution and Comprehensive Mass Spectrometry Analysis of Ambient Particulate Matter

Environmental Non-Targeted Screening: What is in our Air? High-Resolution and Comprehensive Mass Spectrometry Analysis of Ambient Particulate Matter

Dr. Levermore will explore the composition of ambient particulate matter and its implications for occupational health, using advanced MS techniques.

HR and GCxGC GC/MS of Ambient Particulate Matter

The complete Solution for Food Analysis: Presented by Retsch, CEM, Shimadzu and EltraAccurate and rapid food analysis is becoming increasingly important as regulations become stricter and consumers become more demanding. This expert day on food analysis will give you a comprehensive overview of the optimal steps from sample preparation to analysis, familiarize you with modern methods and bring you up to date.Registration is free of charge and without obligation.<div><div><div><div><div><h3>Heavy metals and pesticides in highly processed&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</h3>In the third part of the webinar series the focus is on analytics. Each step of food processing presents a source of contamination, which is why highly processed foods (ultra-processed foods (UPF)) should be viewed critically.Heavy metals are analyzed using ICP-MS and pesticides using GCMS/MS and SFC-LCMS/MS. You have the opportunity to get in touch with device experts and discuss your questions.</div></div>In this webinar, you will learn more about:<ul><li>How to measure pesticides in difficult samples using LC-MS/MS and SFC-MS/MS</li><li>Determination of pesticides in food samples using GC-MS/MS with hydrogen as carrier gas</li><li>Challenges and solutions for heavy metal analysis</li><li>How much heavy metals are lurking in trend food products?</li></ul>Presenters: Uwe Oppermann, Stéphane Moreau, Waldemar Weber and Johannes Hesper</div></div></div>

Heavy metals and pesticides in highly processed

Heavy metals are analyzed using ICP-MS and pesticides using GCMS/MS and SFC-LCMS/MS. 

<div>Join us for the first-ever Semicon e-Symposium, a one-day virtual event featuring expert discussions on crucial topics in the semiconductor industry, including yield improvement, sustainability, PFAS analysis, and advanced analytical techniques.Here’s why you don’t want to miss this:<ul><li>Discover how leading-edge analytical solutions are driving innovation, featuring a plenary talk by Dr. Stefanie Fingerhut from Merck KGaA on transforming semiconductor materials for mobile technology.</li><li>Explore key advancements in vacuum technology and regulatory updates.</li><li>Gain actionable insights from experts in GC-ICP-MS, UV-Vis spectroscopy, and a special talk by Inès Tendero from Technic France on the analysis of silicon in high-purity matrices.</li></ul>This is a must-attend event for anyone looking to stay informed on key trends and cutting-edge advancements in semiconductor manufacturing. Don’t miss out—register today!<h4>Agenda</h4>8:30 a.m. How Analytical Techniques Contribute to Yield Improvement and Environmental Sustainability in the Semiconductor Industry<ul><li>Gernot Hudin, Agilent Technologies</li></ul>9:00 a.m. Plenary Talk: The Hidden Connection: Merck's Advanced Analytical Techniques Transforming Semiconductor Materials for Mobile Technology<ul><li>Dr. Stefanie Fingerhut, Merck KGaA</li></ul>9:45 a.m. Agilent ICP-MS Supplies Selection Tips for the Semiconductor Industry&nbsp;<ul><li>Alain Desprez, Agilent Technologies</li></ul>10:00 a.m. PFAS 'Forever Chemicals'—Forever a Problem?<ul><li>Shifen Xu, Agilent Technologies</li></ul>10:30 a.m. Quantitative Workflow for the Analysis of PFAS in Semiconductor Lubricant with LC-MS (Q-TOF)<ul><li>Peter Kornas, Agilent Technologies</li></ul>11:00 a.m. Agilent Vacuum in Semiconductor Market<ul><li>Fabio Ardissone, Agilent Technologies</li></ul>11:30 a.m. GC, GC/MS, and GC-ICP-MS in Semiconductor: What, Why, and How?<ul><li>Stephane Decouflet, Agilent Technologies</li></ul>12:00 p.m. Lunch break1:00 p.m. Semiconductor Application of Single Particle ICP-MS<ul><li>Yoshinori Shimamura, Agilent Technologies</li></ul>1:30 p.m. Is It Possible to Identify Organic Solvents by ICP-MS?<ul><li>Katsuo Mizobuchi, Agilent Technologies</li></ul>2:00 p.m. Special talk: Analysis of Si in High-Purity Matrix for Semiconductor Application&nbsp;<ul><li>Inès Tendero, Technic France</li></ul>2:30 p.m. Measuring the Band Gap Energy Using UV-Vis Spectroscopy<ul><li>Marcus Schulz, Agilent Technologies</li></ul>2:45 p.m. Recap—closing session<ul><li>Gernot Hudin, Agilent Technologies</li></ul></div>

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