<p><strong>Clarity 10.2 expands instrument control capabilities with new control modules and updates the MS extension to help you work more efficiently.</strong></p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity</strong></a><strong> 10.2 highlights</strong></h4><ul><li>New and updated control modules</li><li>Improved MS data import and export</li><li>Obsolete hardware support ended</li></ul><h4><strong>Instrument control modules</strong></h4><p>Clarity 10.2 introduces new instrument control modules from Annuo (AS-3117, FAS-3823) and updated instrument controls form Sykam and Ecom.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Instrument_control_modules_5de26782b0.jpg" alt="DataApex: Instrument control modules" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Instrument_control_modules_5de26782b0.jpg 228w," sizes="100vw" width="380" height="260"></p><h4><strong>MS data import/export improvements</strong></h4><p>Clarity improves MS data exchange, especially for *.cdf files. MS instruments now support export and import of multiple spectral data and non-spectral signal data in the same CDF file. Import also better handles uniform sampling information, m/z Step values, scale factors, and file names with non-ASCII characters. Exporting individual chromatogram signals from MS instruments is now available through a separate Export Chromatogram dialog.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg" alt="DataApex: MS data import-export improvements" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg 228w," sizes="100vw" width="378" height="259"></p><h4><strong>Obsolete hardware support terminated</strong></h4><p>Due to changes in Windows driver security requirements, this update discontinues support for obsolete hardware, including INT7, INT9, U-PAD, U-PAD2, and CB20.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg" alt="DataApex: Obsolete hardware support terminated" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg 228w," sizes="100vw" width="378" height="259"></p><blockquote><p><strong>Explore the complete list of all changes, fixes, and additions in version 10.2.</strong></p><p><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1"><strong>See the complete changelog&nbsp;</strong></a></p></blockquote>

Clarity Chromatography Software 10.2 released!

<p><strong>Traditional EI library searching works exceptionally well when the unknown compound is already present in the spectral library. However, analytical chemists frequently encounter compounds that are structurally related to library entries but are not exact matches. NIST's EI Hybrid Search addresses this challenge by combining conventional spectral matching with mass-shifted fragment alignment, allowing the identification of analogs, derivatives, and novel compounds that may not exist in the database.</strong></p><p>This guide summarizes the workflow presented by James Little and demonstrates how to use NIST 26 Hybrid Search in conjunction with the Chromatogram Window and MS Interpreter to obtain more meaningful structural information from unknown EI GC-MS spectra.</p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/paper/33370"><strong>You can download PDF Handout for this guide HERE</strong></a></p></blockquote><h4><strong>Why Hybrid Search Matters</strong></h4><p>Conventional EI library searching relies on direct matching between an unknown spectrum and spectra stored in a library. Hybrid Search expands this concept by allowing fragment ions to be matched even when they are shifted by a consistent mass difference (Δm). This enables the software to recognize compounds that differ by substituents or structural modifications.</p><p><strong>Key advantages include:</strong></p><ul><li>Identification of structurally related compounds not present in the library</li><li>Detection of analogs, derivatives, and emerging compounds</li><li>Integration of exact fragment matches and mass-shifted matches into a single score</li><li>Improved interpretation of unknowns through proposed structural modifications</li><li>Enhanced confidence when molecular weight information is available</li></ul><p>Although Hybrid Search does not require the molecular ion to be present, performance improves significantly when the molecular weight can be estimated or constrained. In these cases, the observed mass difference between the unknown and library compounds can often be translated directly into a plausible chemical modification.</p><h4><strong>Configuring Hybrid Search</strong></h4><p>Before performing a search, the Hybrid Search settings should be configured within the NIST Library Search window.</p><p>Recommended settings:</p><ul><li>Select the Similarity search mode</li><li>Enable Hybrid Search</li><li>Keep the In Spectrum option checked under normal circumstances</li><li>Allow the software to estimate the molecular weight automatically</li><li>If the estimated molecular weight appears incorrect, manually enter a nominal molecular weight</li><li>Select all relevant libraries (NIST, Wiley, user libraries, etc.)</li><li>Save the configuration for future use</li></ul><p>The selected molecular weight used to constrain the search is displayed in the lower-right corner after the search is completed.</p><h4><strong>Optimizing the Results Display</strong></h4><p>Hybrid Search produces several unique parameters that are not shown in the default results table.</p><p>Additional columns should be added by right-clicking within the results table and selecting Properties. Recommended columns include:</p><ul><li>DeltaMass</li><li>dForm</li><li>pctRelForm</li><li>o.Match (equivalent to the traditional EI Normal Match score)</li></ul><p>Without these parameters, much of the structural interpretation power of Hybrid Search is lost.</p><h4><strong>Working with Spectra from the Chromatogram Window</strong></h4><p>Currently, the Chromatogram Window performs standard EI library searching. When a potentially interesting unknown is encountered:</p><ul><li>Perform the normal EI search in the Chromatogram Window</li><li>Send the spectrum to the standalone Library Search module</li><li>Perform a Hybrid Search using the enhanced Hybrid Search functionality</li></ul><p>This workflow combines rapid screening with advanced structural interpretation.</p><h4><strong>Understanding Key Hybrid Search Parameters</strong></h4><h5><strong>DeltaMass (Δm)</strong></h5><p>DeltaMass represents the mass difference between the unknown compound and the matched library compound.</p><p>A consistent Δm across multiple high-scoring hits often indicates a specific structural modification.</p><h5><strong>dForm</strong></h5><p>dForm provides a proposed elemental composition that explains the observed mass difference.</p><p>Examples include:</p><ul><li>H–1F</li><li>CH₂</li><li>O–1</li><li>C₁H₃F</li></ul><p>These transformations can suggest likely chemical modifications between the library compound and the unknown.</p><h5><strong>pctRelForm</strong></h5><p>New in NIST 26, pctRelForm estimates how frequently a given elemental transformation occurs relative to the most common transformation (CH₂ = 100%).</p><p>Interpretation:</p><ul><li>High values indicate chemically plausible and commonly observed transformations</li><li>Very low values suggest the proposed transformation may be accidental or unlikely</li></ul><h5><strong>o.Match</strong></h5><p>Represents the traditional EI match score and allows comparison between standard searching and Hybrid Search results.</p><h4><strong>Case Study: Identifying a Fluorinated Unknown</strong></h4><p>The presentation demonstrates the identification of an unknown compound with a proposed molecular weight of 152 Da.</p><p>Hybrid Search returned several high-scoring hits with consistent evidence suggesting fluorine substitution:</p><p><strong>Hit #1</strong></p><ul><li>Library MW: 134</li><li>DeltaMass: +18</li><li>dForm: H–1F</li><li>Interpretation: Addition of fluorine</li></ul><p><strong>Hit #5</strong></p><ul><li>Library MW: 138</li><li>DeltaMass: +14</li><li>dForm: CH₂</li><li>Interpretation: Related fluorinated analog</li></ul><p><strong>Hit #6</strong></p><ul><li>Library MW: 168</li><li>DeltaMass: –16</li><li>dForm: O–1</li><li>Interpretation: Structurally consistent fluorinated compound</li></ul><p>Multiple independent hits converged on the same conclusion: the unknown was likely a fluorinated analog of known aromatic compounds.</p><p>This illustrates the major strength of Hybrid Search: identifying structural relationships even when the exact compound is absent from the library.</p><h4><strong>Moving from Hybrid Search to Structural Interpretation</strong></h4><p>Once a plausible structure is identified:</p><h5><strong>Step 1 – Export the Structure</strong></h5><p>From the Hybrid Search results:</p><ul><li>Right-click the best hit</li><li>Use Send To → Default Structure Editor</li><li>Open the structure in a drawing program such as ChemSketch</li><li>Copy the proposed structure to the clipboard</li></ul><h5><strong>Step 2 – Open MS Interpreter</strong></h5><p>Within MS Interpreter:</p><ul><li>Paste the proposed structure</li><li>Load the unknown spectrum</li><li>Compare predicted fragmentation with observed ions</li><li>Evaluate isotope patterns and fragment assignments</li></ul><h5><strong>Step 3 – Validate the Proposal</strong></h5><p>Indicators of a good structural proposal include:</p><ul><li>Consistent isotope ratios</li><li>Logical fragmentation pathways</li><li>Agreement between observed and predicted fragment ions</li><li>Multiple Hybrid Search hits supporting the same structural modification</li></ul><p>In the example presented, MS Interpreter showed excellent agreement between the proposed fluorinated structure and the observed EI spectrum, although the exact positions of the fluorine and methyl substituents on the aromatic ring could not be definitively assigned.</p><h4><strong>Best Practices</strong></h4><ul><li>Always review DeltaMass, dForm, and pctRelForm together</li><li>Do not rely solely on the highest match score</li><li>Give greater weight to transformations supported by multiple independent hits</li><li>Use molecular weight information whenever possible</li><li>Confirm structural hypotheses using MS Interpreter</li><li>Consider Hybrid Search as a structure-elucidation tool rather than simply a library search tool</li></ul><h4><strong>Conclusion</strong></h4><p>NIST 26 Hybrid Search significantly extends the capabilities of conventional EI library searching by identifying structural relationships between unknown compounds and library entries. Through the use of DeltaMass calculations, elemental transformation analysis (dForm), and statistical plausibility metrics (pctRelForm), Hybrid Search provides valuable clues for elucidating compounds that are absent from spectral libraries.</p><p>When combined with MS Interpreter, it becomes a powerful workflow for the characterization of unknowns, analogs, degradation products, metabolites, and emerging compounds in EI GC-MS analysis.</p>

Lib Search: Similarity EI Hybrid Search for Spectra Sent from Chromatogram Window

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 22nd June 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you brochure by <strong>Agilent Technologies, </strong>application note<strong> </strong>by<strong> Shimadzu </strong>and posters by <strong>MDCW / William &amp; Mary </strong>and <strong>Waters Corporation / ASMS!</strong></p><h3><strong>1. Agilent Technologies: Operational efficiency for your GC and GC/MS labs with the </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B"><strong>Agilent 8890B gas chromatography system</strong></a></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/br_8890b_gc_5994_9205en_agilent_fb5db29527.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><h4><strong>Analyze more samples every day with faster cycle times&nbsp;</strong></h4><p>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B"><strong>8890B GC </strong></a>provides faster maximum oven temperature ramps and cooldown rates for conventional dual-channel GC. If you want even faster cycle times, an optional rapid cooling fan is available.&nbsp;</p><h4><strong>Achieve excellent repeatability across multiple injections&nbsp;</strong></h4><p>Consistent retention time and area count performance are the cornerstone of what you can expect from the 8890B GC. The system also meets all specifications required for regulatory methods such as USP Method &lt;467&gt; (residual solvents).</p><h4><strong>Shine a new light on your connections and components&nbsp;</strong></h4><p>Make maintenance easier and faster with a built-in oven light that illuminates the internal space on the 8890B GC. That means you can perform tasks like troubleshooting and column installation in less time—and with fewer errors.</p><h4><strong>Boost GC performance with capillary flow technology&nbsp;</strong></h4><ul><li><strong>Backflush</strong> significantly reduces timing between injections, increasing productivity.&nbsp;</li><li><strong>Purged Ultimate unions</strong> provide leak-free connections, reducing downtime.&nbsp;</li><li><strong>Flow splitters</strong> enable data collection from up to three detectors.&nbsp;</li><li><strong>New CFT calculators</strong> let you download calculated setpoints to your method—avoiding time-consuming, error-prone manual input.&nbsp;</li><li><strong>Multidimensional chromatography:&nbsp;</strong><ul><li><strong>Deans Switch</strong> facilitates heart cutting, enabling resolution of trace compound in complex matrices.&nbsp;</li><li><strong>GC x GC flow modulation</strong> enables multidimensional chromatography without the need for cryogen</li></ul></li></ul><h4><strong>Helium conservation module&nbsp;</strong></h4><p>Extend the life of your helium tanks by up to 30 times. The Agilent helium conservation module allows you to use helium for your GC runs and switch to a different gas (typically nitrogen) when your GC is idle. That means you can achieve better control of laboratory operating expenses and avoid workflow disruptions.</p><h4><strong>Alternative carrier gas support&nbsp;</strong></h4><p>Alternative carrier gases like hydrogen and nitrogen are popular low-cost options.&nbsp;</p><p>The <strong>Agilent Hydrogen Sensor Module Series 2 </strong>option adds built-in peace of mind when operating with H2 gas.&nbsp;</p><p>The <strong>Agilent HydroInert source </strong>minimizes sensitivity loss and spectral anomalies associated with H2. It also:&nbsp;</p><ul><li>Maintains spectral fidelity, even for compounds highly susceptible to hydrogenation.&nbsp;</li><li>Improves peak shape for high-boilers, especially polycyclic aromatic hydrocarbons (PAHs)</li></ul><h3><strong>2. MDCW / William &amp; Mary: Decomposition Analysis Using Differing Data Processing Methods to Identify Volatile Organic Compounds</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/P_25_Weina_2ae94f0998.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>When a body decomposes it emits volatile organic compounds (VOCs). VOCs from decomposing remains have been studied before,1 however there is a gap that remains in the knowledge on VOCs that evolve from submerged decomposing remains. 2 In this study, submerged animal tissue was tested to see how the VOCs can be utilized in forensic settings.&nbsp;</p><p>This study used data obtained last summer using comprehensive two-dimensional gas chromatography – time-of-flight mass spectrometry (GC×GC-TOFMS). Pigs (Sus scrofa domesticus) are often used as analogs in decomposition studies due to similarities with humans. 3 In this study, pork belly samples were submerged in mason jars filled with water and stored at different temperatures. The GC×GC-TOFMS instrument was used to collect odor from above water samples for a period of twelve days.</p><p>GC×GC is often used to analyze complex odor profiles. When analyzing samples with GC×GC, there is a lack of standardization to process the data acquired from time trials. There is a need to discover effective ways to track VOCs for chemical identification and longitudinal analysis.</p><p>The goal of this research was to compare different software approaches to analyze GC×GC longitudinal data to achieve accurate analyte identification, representation of data over time, and effective class characterization.</p><h4><strong>Methods</strong></h4><p>For the first four days, 5 mL of water was taken and run on the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37"><strong>GC×GC-TOFMS</strong></a>. Thereafter, the samples were sampled and run every three days until day twelve. Data were analyzed initially using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/41"><strong>ChromaTOF</strong></a> (LECO Corporation). The samples were then analyzed using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/348"><strong>ChromaTOF Tile </strong></a>and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1873"><strong>ChromaTOF Sync 2D</strong></a> to compare how they can be used in a forensic setting.</p><p>Peak tables were curated in Tile and Sync 2D. Then, ChromaTOF was used as a guide to confirm which peaks were identified correctly. If the compound was correctly identified, the peak would be accepted or kept on the table. If not correctly identified, the peak would either be rejected or deleted. Once the tables were complete from the different software approaches, they were exported to Excel for further comparison.</p><p>In excel, the relevant hits that were identified as decomposition VOCs were compared across the software approaches. The compounds that were most commonly found were compared to existing literature on decomposition VOCs. From there, two tables were built; where one table was compounds confirmed with literature and the other table was compounds not confirmed with literature.</p><p>Comparison between software approaches included looking at different criteria to see which method was the most effective and efficient. The criteria included how long the software approach took, the number of compounds found in each software approach, the accuracy of peak area in the software approach compared to ChromaTOF data, and principal component analysis (PCA) comparison to see which software approach was best used for forensic practice or research.</p><h4><strong>Conclusions</strong></h4><p>Sync 2D showed the capability of showing trends in decomposition compounds</p><ul><li>This software approach can be used in research environment where longitudinal data is needed to determine the trends of decomposition data&nbsp;</li><li>Best purpose: research applications requiring longitudinal tracking&nbsp;</li></ul><p>Coefficient of Variance’s and Fold Change’s PCA plots showed their ability for clear class differentiation&nbsp;</p><ul><li>The two software approaches can be used to distinguish water containing decomposition in a crime scene&nbsp;</li><li>Best purpose: comparison at a single point and time [detailed analysis]&nbsp;</li></ul><p>Fisher Ratio showed a proficiency in identifying top differentiating compounds and showed aptitude for class differentiation&nbsp;</p><ul><li>The software approach would be helpful for cursory analysis for crime scene evidence&nbsp;</li><li>Best purpose: quick comparison of biggest difference for swift identification</li></ul><h3><strong>3. Shimadzu: Determination of Ester and Linolenic Acid Methyl Ester Contents in Biodiesel According to EN 14103:2020</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_05_sca_180_054_en_93d1029b72.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=2060"><strong>NexisTM GC-2060</strong></a> provides reliable analysis of biodiesel samples regarding their ester and linolenic acid methyl ester contents using hydrogen as a cost-effective carrier gas&nbsp;</li><li>It delivers excellent repeatability and provides appropriate safety measures for the use of hydrogen as carrier gas&nbsp;</li><li>The optional multi-mode injection unit (MMI) offers performance equivalent to a conventional split-splitlessinjection unit (SPL), significantly reducing maintenance downtime</li></ul><p>Biofuels play an important role in enabling countriesto meet their greenhouse gas reduction targets. They can be produced from a range of raw materials, including plant oils, animal fats, and used cooking oils. Biodiesel is mainly being produced from rapeseed, soybean, and palm oils. Due to this diversity of feedstocks, continuous quality control is necessary as the quality of the raw material has an enormousimpact on the quality of the biodiesel.&nbsp;</p><p>The EN 14103:2020 describes the determination of total ester content and linolenic acid methyl ester content in biodiesel by means of gas chromatography with flame ionization detection (GC-FID). The total ester content covers a range of fatty acid methyl esters (FAME) from C6 to C24, and linolenic acid methyl ester is investigated separately as interfering reactive compound that might influence long-term stability of the biodiesel. According to the standard, the total ester content must be greater than 90 % (m/m) and the linolenic acid methyl ester content shall be between 1 and 15 % (m/m)1.</p><p>This study shows the analysis of biodiesel originating from rapeseed,soybean, and palm oil using the Nexis GC-2060.</p><h4><strong>Multi-Mode Injection Unit as Alternative&nbsp;</strong></h4><p>Shimadzu’s multi-mode injection unit (MMI) offers reliable splitsplitless mode functionality over a broad range of carbon numbers. It allows analysis of biodiesel samples with high repeatability and provides chromatographic results comparable to those measured with SPL as dedicated split-splitless injection unit. The use of MMI significantly shortens maintenance downtime from tens of minutes for a classical split-splitless injection unit to just a few minutes. Figure 3 gives a direct comparison of an exemplary rapeseed-based biodiesel sample measured with SPL (top) and MMI (bottom).</p><h4><strong>Conclusion</strong></h4><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=2060"><strong>Nexis GC-2060</strong></a> provides reliable analysis of biodiesel samples regarding their ester and linolenic acid methyl ester content according to EN 14103:2020, covering the various ester types commonly in use. It allows repeatable analysis using hydrogen as a cost-effective carrier gas. The optional multi-mode injection unit (MMI) can be selected as alternative to a classical splitsplitlessinjection unit (SPL).</p><h3><strong>4. Waters Corporation / ASMS: Putting the (Atmospheric) Pressure on Forever Chemicals: A Targeted Analysis of GC Amenable PFAS using APGC–MS/MS</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009413_dfa4082b45.pdf"><strong>Full PDF for download</strong></a></li></ul><p>This poster presents a targeted analytical method for the determination of gas chromatography (GC)-amenable PFAS compounds using atmospheric pressure gas chromatography coupled with tandem mass spectrometry (APGC-MS/MS). The study addresses a key limitation of conventional LC-MS/MS methods, which are highly effective for many PFAS but less suitable for more volatile species such as fluorotelomer alcohols (FTOHs), fluorotelomer acrylates (FTAcr), and fluorotelomer acetates (FTOAc). By incorporating GC-MS/MS analysis, laboratories can obtain a more complete characterization of PFAS contamination across environmental, biological, and food-contact materials.</p><p>The analytical workflow utilized an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890"><strong>Agilent 8890 gas chromatograph</strong></a> equipped with an autosampler and coupled to a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/554"><strong>Waters Xevo TQ Absolute tandem mass spectrometer</strong></a> operated with APGC ionization in positive-ion mode. Separation was performed on an Rtx-200 capillary column, while data acquisition and quantification were managed using <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544"><strong>waters_connect software</strong></a>. Unlike traditional electron ionization (EI), APGC generated intact protonated molecular ions, significantly improving sensitivity and selectivity for GC-amenable PFAS. A method covering 35 PFAS compounds was developed, achieving lower limits of quantification (LLOQs) of 0.025–0.1 ng/mL for most analytes.</p><p>Several sample types were evaluated, including wastewater, surface water, soil, fish tissue, shrimp, and food-packaging materials. Environmental and biological samples were prepared according to EPA Method 1633A and had previously been analyzed by LC-MS/MS, allowing the GC-MS/MS method to serve as a complementary technique. Food-packaging samples were extracted with methanol containing ammonium hydroxide and analyzed for targeted PFAS. While no target PFAS were detected in the tested packaging materials, multiple GC-amenable PFAS were found in environmental samples. Fluorotelomer alcohols were the most frequently detected compounds, with wastewater and ski-wax-impacted soils showing the highest concentrations.</p><p>The results demonstrate that APGC-MS/MS provides a sensitive and robust solution for the analysis of volatile PFAS classes that may be missed by LC-MS/MS alone. The method delivered accurate quantification, effective chromatographic separation, and reliable recovery in spiked samples. The authors conclude that combining APGC-MS/MS with established LC-MS/MS workflows enables a more comprehensive assessment of PFAS contamination, particularly for emerging fluorotelomer compounds and other GC-amenable PFAS that are increasingly relevant in environmental monitoring and food-packaging investigations.</p></div></div></div></div></div></div></section></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 26, 2026

Article

Product

Application

Academy

Video

Software

Poster

Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

DataApex

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

James Little/Mass Spec Interpretation Services

LECO PEGASUS BTX GC-TOFMS

Discover the LECO Pegasus BTX GC-TOFMS: next-generation TOF technology with femtogram sensitivity, StayClean® ion source, and full-spectrum acquisition for GC and GC×GC applications.

<p><strong>The Pegasus BTX represents the culmination of nearly 30 years of LECO innovation in time-of-flight mass spectrometry for GC and GC×GC applications. Designed for laboratories that demand uncompromising sensitivity, speed, and robustness, the BTX delivers full-spectrum data at all times—even during targeted analyses—so no chemical information is ever lost.</strong></p><h3><strong>Why Pegasus BTX?</strong></h3><p><strong>See Everything, All the Time</strong><br>Collect complete mass range data while running targeted methods. Never miss unknowns or unexpected components hidden in complex matrices.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_LECO_PEGASUS_BTX_GC_TOFMS_Collect_full_mass_range_data_even_when_performing_targeted_analyses_Never_miss_another_clue_ee49884729.jpg" alt="LECO PEGASUS BTX GC-TOFMS: Collect full mass range data, even when performing targeted analyses. Never miss another clue..jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_LECO_PEGASUS_BTX_GC_TOFMS_Collect_full_mass_range_data_even_when_performing_targeted_analyses_Never_miss_another_clue_ee49884729.jpg 245w," sizes="100vw" width="771" height="350"></p><p><strong>Advanced Deconvolution Algorithms</strong><br>Powerful spectral deconvolution extracts clean, interpretable spectra—even from the densest chromatograms.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_LECO_PEGASUS_BTX_GC_TOFMS_Even_in_the_densest_of_matrices_uncovering_analytes_is_easier_than_ever_with_the_help_of_clean_spectra_0a5a1afa9b.jpg" alt="LECO PEGASUS BTX GC-TOFMS: Even in the densest of matrices, uncovering analytes is easier than ever with the help of clean spectra..jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_LECO_PEGASUS_BTX_GC_TOFMS_Even_in_the_densest_of_matrices_uncovering_analytes_is_easier_than_ever_with_the_help_of_clean_spectra_0a5a1afa9b.jpg 245w," sizes="100vw" width="712" height="350"></p><p><strong>StayClean® Ion Source – No Routine Cleaning</strong><br>The proven StayClean® direct-extraction EI source eliminates the need for source cleaning, even after prolonged exposure to heavy matrices, maximizing uptime.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_LECO_PEGASUS_BTX_GC_TOFMS_Stay_running_with_the_Stay_Clean_ion_source_which_requires_no_cleaning_even_after_sustained_heavy_matrix_exposure_8954521617.jpg" alt="LECO PEGASUS BTX GC-TOFMS: Stay running with the StayClean­® ion source, which requires no cleaning, even after sustained heavy matrix exposure..jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_LECO_PEGASUS_BTX_GC_TOFMS_Stay_running_with_the_Stay_Clean_ion_source_which_requires_no_cleaning_even_after_sustained_heavy_matrix_exposure_8954521617.jpg 245w," sizes="100vw" width="729" height="350"></p><p><strong>Sensitivity in Spades</strong><br>Achieve trace-level detection down to <strong>femtogram levels</strong> using either helium or hydrogen carrier gas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_LECO_PEGASUS_BTX_GC_TOFMS_Trace_level_detection_with_helium_or_hydrogen_carrier_gases_no_analytes_escape_detection_d3eb2da878.jpg" alt="LECO - LECO PEGASUS BTX GC-TOFMS -Trace-level detection with helium or hydrogen carrier gases - no analytes escape detection.jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_LECO_PEGASUS_BTX_GC_TOFMS_Trace_level_detection_with_helium_or_hydrogen_carrier_gases_no_analytes_escape_detection_d3eb2da878.jpg 245w," sizes="100vw" width="711" height="350"></p><p><strong>New Generation TOF Technology</strong><br>A novel ion path and detector design delivers extraordinary sensitivity in a compact benchtop footprint—revealing analytes that escape conventional GC-MS systems.</p><p><strong>Built for Reliability</strong><br>Backed by LECO’s commitment to robustness, every BTX includes a <strong>two-year detector warranty</strong>, underscoring confidence in ion path and detector integrity.</p><h3><strong>Proven Platform, Elevated Performance</strong></h3><p>Building on more than 8 years of field-proven Pegasus BT systems, the BTX retains what users trust—<a target="_blank" rel="noopener noreferrer" href="https://www.leco.com/documents/app-notes/203-821-569/?_gl=1*121vl09*_up*MQ..*_ga*OTgyMzg3MTkuMTc2NzgxMTMwNA..*_ga_KRDSR1XM7X*czE3Njc4MTEzMDQkbzEkZzAkdDE3Njc4MTEzMDQkajYwJGwwJGgw*_ga_K8NYKVEKHY*czE3Njc4MTEzMDQkbzEkZzAkdDE3Njc4MTEzMDQkajYwJGwwJGgxNjI1OTMyNjA5"><strong>StayClean® ion source</strong></a><strong>, ultrafast full-spectrum acquisition, and 5 orders of linear dynamic range</strong>—while pushing sensitivity and performance to a new level. It is ideally suited for demanding, non-targeted and discovery-driven workflows across:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.leco.com/applications/petrochemical-analysis/?_gl=1*1819onr*_up*MQ..*_ga*OTgyMzg3MTkuMTc2NzgxMTMwNA..*_ga_KRDSR1XM7X*czE3Njc4MTEzMDQkbzEkZzAkdDE3Njc4MTEzMDQkajYwJGwwJGgw*_ga_K8NYKVEKHY*czE3Njc4MTEzMDQkbzEkZzAkdDE3Njc4MTEzMDQkajYwJGwwJGgxNjI1OTMyNjA5"><strong>Petroleum &amp; energy</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.leco.com/industry/agriculture-environmental/?_gl=1*o0u7vp*_up*MQ..*_ga*OTgyMzg3MTkuMTc2NzgxMTMwNA..*_ga_KRDSR1XM7X*czE3Njc4MTEzMDQkbzEkZzAkdDE3Njc4MTEzMDQkajYwJGwwJGgw*_ga_K8NYKVEKHY*czE3Njc4MTEzMDQkbzEkZzAkdDE3Njc4MTEzMDQkajYwJGwwJGgxNjI1OTMyNjA5"><strong>Environmental analysis</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.leco.com/applications/metabolomics/?_gl=1*1ttdc4g*_up*MQ..*_ga*OTgyMzg3MTkuMTc2NzgxMTMwNA..*_ga_KRDSR1XM7X*czE3Njc4MTEzMDQkbzEkZzAkdDE3Njc4MTEzMDQkajYwJGwwJGgw*_ga_K8NYKVEKHY*czE3Njc4MTEzMDQkbzEkZzAkdDE3Njc4MTEzMDQkajYwJGwwJGgxNjI1OTMyNjA5"><strong>Life sciences</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.leco.com/industry/pharma/?_gl=1*121vl09*_up*MQ..*_ga*OTgyMzg3MTkuMTc2NzgxMTMwNA..*_ga_KRDSR1XM7X*czE3Njc4MTEzMDQkbzEkZzAkdDE3Njc4MTEzMDQkajYwJGwwJGgw*_ga_K8NYKVEKHY*czE3Njc4MTEzMDQkbzEkZzAkdDE3Njc4MTEzMDQkajYwJGwwJGgxNjI1OTMyNjA5"><strong>Pharmaceuticals</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.leco.com/industry/food-safety/?_gl=1*121vl09*_up*MQ..*_ga*OTgyMzg3MTkuMTc2NzgxMTMwNA..*_ga_KRDSR1XM7X*czE3Njc4MTEzMDQkbzEkZzAkdDE3Njc4MTEzMDQkajYwJGwwJGgw*_ga_K8NYKVEKHY*czE3Njc4MTEzMDQkbzEkZzAkdDE3Njc4MTEzMDQkajYwJGwwJGgxNjI1OTMyNjA5"><strong>Food safety</strong></a></li><li>Forensic and other complex-matrix applications</li></ul><h3><strong>Key Technical Specifications</strong></h3><ul><li><strong>Ionization Source:</strong> Electron Ionization (StayClean® direct-extraction, open style)</li><li><strong>Mass Analyzer:</strong> Time-of-Flight with dual-stage single reflectron</li><li><strong>Detector:</strong> Scintillator–Photomultiplier Tube (extended lifetime)</li><li><strong>Mass Range:</strong> 10–1500 m/z</li><li><strong>Mass Resolution:</strong> &gt;1,100 at m/z 219</li><li><strong>Spectral Acquisition Rate:</strong> 1–500 spectra/s (up to 35,000 transients/s)</li><li><strong>Detection Limit (He carrier gas):</strong> 10 fg OFN, Quant S/N &gt;10</li><li><strong>Detection Limit (H₂ carrier gas):</strong> 10 fg OFN, Quant S/N &gt;10</li><li><strong>IDL:</strong> &lt;4 fg (8 replicates of 10 fg OFN)</li><li><strong>Precision:</strong> &lt;5 % RSD (15 injections of 100 fg OFN)</li><li><strong>Linear Dynamic Range:</strong> 5 orders of magnitude</li></ul>

LECO PEGASUS BT GC-TOFMS

Compact GC-TOFMS delivering full mass range data in every run, high sensitivity, NonTarget Deconvolution® and StayClean® EI source for reliable non-target and routine GC-MS analysis.

<p><strong>The Pegasus BT GC-TOFMS is a compact, high-performance benchtop gas chromatography time-of-flight mass spectrometer designed to deliver comprehensive chemical information with exceptional sensitivity, speed, and reliability. It combines advanced TOF mass spectrometry hardware with LECO’s powerful </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/41"><strong>ChromaTOF® software</strong></a><strong> to support both routine and advanced analytical workflows.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_Pegasus_BT_2_bc8a8d0505.jpg" alt="LECO PEGASUS BT GC-TOFMS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_Pegasus_BT_2_bc8a8d0505.jpg 238w," sizes="100vw" width="932" height="612"></p><p>Designed for laboratories that need to analyze more samples, generate more data, and achieve results faster, the Pegasus BT acquires full-range mass spectral data in every run—ensuring that no analytes are missed, even in highly complex matrices. Industry-leading sensitivity, combined with <strong>NonTarget Deconvolution® (NTD®)</strong>, enables confident identification and quantification of both known and unknown compounds by effectively separating co-eluting peaks and minimizing matrix interferences.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_PEGASUS_BT_GC_TOFMS_7_be16be31ec.jpg" alt="LECO PEGASUS BT GC-TOFMS: NonTarget Deconvolution® (NTD®) Automated deconvolution ensures that coeluting peaks and matrix interferences don't hinder your analyses.StayClean Ion Source Open-style EI source virtually eliminates downtime associated with source cleaning*, which means you can spend your time running more samples.  *Even after 3,000 sludge injections, source has not needed cleaning." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_PEGASUS_BT_GC_TOFMS_7_be16be31ec.jpg 245w," sizes="100vw" width="768" height="432"></p><p>The system features LECO’s proven <strong>StayClean® open-style EI ion source</strong>, which virtually eliminates downtime associated with source cleaning and allows extended operation even with challenging sample matrices. Its compact benchtop footprint makes the Pegasus BT an ideal solution for laboratories with limited space, without compromising analytical performance.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_PEGASUS_BT_GC_TOFMS_6_047f81e642.jpg" alt="LECO PEGASUS BT GC-TOFMS: " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_PEGASUS_BT_GC_TOFMS_6_047f81e642.jpg 245w," sizes="100vw" width="616" height="375"></p><p>Fully integrated <strong>ChromaTOF® software</strong> provides automated deconvolution, quantification, reporting, batch processing, and long-term data mining. The Pegasus BT GC-TOFMS is ideally suited for pesticide analysis, metabolomics, petroleum and fuel characterization, food, flavor, and fragrance analysis, and other demanding GC-MS applications.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_PEGASUS_BT_GC_TOFMS_2_cc1a963b9e.jpg" alt="LECO PEGASUS BT GC-TOFMS: ChromaTOF® software" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_PEGASUS_BT_GC_TOFMS_2_cc1a963b9e.jpg 245w," sizes="100vw" width="943" height="566"></p><h3><strong>Key Features</strong></h3><ul><li><strong>Benchtop GC-TOFMS</strong> with full-range mass spectral acquisition in every analysis</li><li><strong>Industry-leading sensitivity</strong> for trace-level detection</li><li><strong>NonTarget Deconvolution® (NTD®)</strong> for reliable separation of co-eluting compounds and suppression of matrix interferences</li><li><strong>StayClean® open-style EI ion source</strong> for minimal maintenance and reduced downtime</li><li><strong>High sample throughput with excellent repeatability</strong></li><li><strong>Compact footprint </strong>with uncompromised analytical performance</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_PEGASUS_BT_GC_TOFMS_5fd6d4a332.jpg" alt="LECO PEGASUS BT GC-TOFMS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_PEGASUS_BT_GC_TOFMS_5fd6d4a332.jpg 245w," sizes="100vw" width="1220" height="591"></p><h3><strong>Applications</strong></h3><ul><li>Pesticides and environmental contaminants</li><li>Petroleum products, fuels, and fuel marker analysis</li><li>Metabolomics and non-target screening</li><li>Food, flavor, and fragrance analysis</li><li>Characterization of complex matrices and unknown identification</li></ul><h5><strong>&nbsp;Calibration curve in strawberry matrix: Cyprodinil</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_PEGASUS_BT_GC_TOFMS_3_6a4f0ecc50.jpg" alt="LECO PEGASUS BT GC-TOFMS: The calibration curve at left shows excellent linearity, and sensitivity easily meets all standard requirements." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_PEGASUS_BT_GC_TOFMS_3_6a4f0ecc50.jpg 245w," sizes="100vw" width="871" height="480"></p><h5><strong>Characterization of fuel markers at trace levels is easy and routine</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_PEGASUS_BT_GC_TOFMS_4_33217d7f2e.jpg" alt="LECO PEGASUS BT GC-TOFMS: Full TIC chromatogram of a spiked commercial diesel sample." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_PEGASUS_BT_GC_TOFMS_4_33217d7f2e.jpg 237w," sizes="100vw" width="742" height="489"></p>

LECO PEGASUS BT 4D GC×GC-TOFMS

LECO PEGASUS BT 4D GC×GC-TOFMS combines comprehensive two-dimensional GC with fast TOFMS to improve separation, sensitivity, and confidence in qualitative and quantitative analysis of complex samples.

<p><strong>The LECO PEGASUS BT 4D GC×GC-TOFMS is a high-performance benchtop system that combines comprehensive two-dimensional gas chromatography (GC×GC) with time-of-flight mass spectrometry (TOFMS) to deliver unmatched separation power, sensitivity, and confidence in compound identification. Designed for laboratories facing highly complex samples, the PEGASUS BT 4D enables qualitative and quantitative analysis in a single run while maximizing productivity and data quality.</strong></p><p>By coupling GC×GC separation with fast TOFMS acquisition, the system <strong>dramatically increases chromatographic peak capacity and resolves co-eluting compounds </strong>that are difficult or impossible to distinguish by conventional 1D GC-MS. Enhanced signal-to-noise ratios translate into lower detection limits, improved linearity, and more reliable quantification—even in challenging matrices.</p><h3><strong>What GC×GC Brings to Your Analysis</strong></h3><p>GC×GC modulation refocuses and reinjects analytes from the first column into a second column with a different stationary phase, providing structured chromatograms that improve interpretability of complex data. This approach improves both separation efficiency and interpretability of results, allowing you to identify more compounds with greater confidence and consistency.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_PEGASUS_BT_4_D_G_Cx_GC_TOFMS_c9ad0bd186.jpg" alt="LECO PEGASUS BT 4D GC×GC-TOFMS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_PEGASUS_BT_4_D_G_Cx_GC_TOFMS_c9ad0bd186.jpg 245w," sizes="100vw" width="1029" height="594"></p><h3><strong>Confident Identification and Quantification</strong></h3><p>The PEGASUS BT 4D excels in both comprehensive screening and targeted applications. Spectral deconvolution combined with high-speed TOFMS acquisition reveals analytes present in complex matrices, while GC×GC separation minimizes matrix interferences for superior quantitative performance. What was once a marginal library match in GC-MS becomes a confident identification in GC×GC-TOFMS.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_PEGASUS_BT_4_D_G_Cx_GC_TOFMS_2_4e033e866c.jpg" alt="LECO PEGASUS BT 4D GC×GC-TOFMS: Quantitative analysis using the Pegasus BT 4D" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_PEGASUS_BT_4_D_G_Cx_GC_TOFMS_2_4e033e866c.jpg 245w," sizes="100vw" width="1443" height="637"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_PEGASUS_BT_4_D_G_Cx_GC_TOFMS_3_18eebd600d.jpg" alt="LECO PEGASUS BT 4D GC×GC-TOFMS: Qualitative analysis using the Pegasus BT 4D" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_PEGASUS_BT_4_D_G_Cx_GC_TOFMS_3_18eebd600d.jpg 210w," sizes="100vw" width="1442" height="1069"></p><h3><strong>Robust Design for High-Throughput Labs</strong></h3><p>Equipped with LECO’s proven StayClean® ion source, the PEGASUS BT 4D minimizes routine maintenance and downtime, even when analyzing dirty or complex samples. Integrated with <strong>ChromaTOF®</strong> software, the system provides seamless instrument control, automated data processing, and powerful qualitative and quantitative tools within a single platform.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_PEGASUS_BT_4_D_G_Cx_GC_TOFMS_c2644cd38e.jpg" alt="LECO - PEGASUS BT 4D GCxGC-TOFMS.jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_PEGASUS_BT_4_D_G_Cx_GC_TOFMS_c2644cd38e.jpg 202w," sizes="100vw" width="1099" height="849"></p><h3><strong>Key Benefits</strong></h3><ul><li>Exceptional chromatographic resolution and peak capacity with GC×GC</li><li>Enhanced sensitivity and lower detection limits through modulation-based signal focusing</li><li>High-speed TOFMS acquisition for accurate deconvolution of narrow GC×GC peaks</li><li>Reliable identification and quantification of analytes</li><li>Reduced maintenance with the StayClean® ion source</li><li>Fully integrated ChromaTOF® software for acquisition, processing, and reporting</li></ul><h3><strong>Applications</strong></h3><p>The LECO PEGASUS BT 4D GC×GC-TOFMS is ideally suited for demanding applications across environmental analysis, petrochemical and energy research, food and flavor/fragrance analysis, forensics, life sciences, and metabolomics—anywhere complex mixtures require maximum separation power and analytical confidence.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_PEGASUS_BT_4_D_G_Cx_GC_TOFMS_4_8e8ec115ec.jpg" alt="LECO PEGASUS BT 4D GCxGC-TOFMS: Excellent Sensitivity" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_PEGASUS_BT_4_D_G_Cx_GC_TOFMS_4_8e8ec115ec.jpg 244w," sizes="100vw" width="974" height="625">With the PEGASUS BT 4D, you can <strong>predict, quantify, and identify more compounds with confidence</strong>, turning complex data into clear, actionable results.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_PEGASUS_BT_4_D_G_Cx_GC_TOFMS_5_625fed2f0d.jpg" alt="LECO PEGASUS BT 4D GCxGC-TOFMS: Identify MORE with confidence/non-target analysis" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_PEGASUS_BT_4_D_G_Cx_GC_TOFMS_5_625fed2f0d.jpg 240w," sizes="100vw" width="1034" height="672"></p>

LECO Pegasus GC-HRT+

Ultra-high-resolution GC-TOFMS with up to 50,000 FWHM, <1 ppm mass accuracy, and 200 spectra/s. Pegasus GC-HRT+ delivers unmatched sensitivity and confident identification in complex samples.

<p><strong>Now with even higher sensitivity, the Pegasus GC-HRT+ is designed to meet the most demanding analytical challenges. This high-performance GC-TOFMS delivers industry-leading mass accuracy, full-range acquisition at exceptional speed, precise isotopic abundance, and ultra-high mass resolution—all within a single injection.</strong></p><p>Folded Flight Path (FFP) technology combined with a novel data acquisition system enables up to <strong>50,000 FWHM resolution</strong>, <strong>&lt;1 ppm mass accuracy</strong>, and <strong>acquisition rates up to 200 spectra/s</strong>, supporting rich analyte discovery and high-confidence identification in highly complex samples.</p><h3><strong>Key features</strong></h3><ul><li><strong>Mass accuracy ≤1 ppm</strong> with peak capacity at least <strong>2× higher</strong> than conventional MS platforms</li><li><strong>Encoded Frequent Pushing (EFP)</strong> for markedly increased sensitivity, expanded dynamic range, and wide mass range</li><li><strong>Folded Flight Path (FFP)</strong> technology for ultra-high resolution, enhanced sensitivity, and advanced TOF focusing</li><li><strong>KADAS®</strong> ion-statistics-based acquisition to reduce noise, ensure mass accuracy, and minimize file size</li><li><strong>Ultra High Resolution + HRD</strong> to resolve highly isobaric ions (mass differences ~0.02 amu)</li><li><strong>Multi-Mode Source (MMS):</strong> EI, Positive CI, and ECNI in one system</li></ul><h3><strong>Models</strong></h3><ul><li><strong>Pegasus GC-HRT+</strong> – Full-scale GC-TOFMS</li></ul><h3><strong>Options</strong></h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/82"><strong>L-PAL3 Automated Sample Injector</strong></a></li></ul>

LECO Pegasus GC-HRT+ 4D

High-resolution GC×GC-TOFMS system combining extreme separation power, up to 200 spectra/s acquisition, and advanced HR deconvolution for confident identification of unknowns in complex samples.

<p><strong>The Pegasus GC-HRT+ 4D from </strong><span><strong>LECO</strong></span><strong> combines comprehensive two-dimensional gas chromatography (GC×GC) with high-resolution time-of-flight mass spectrometry (TOFMS) and advanced High-Resolution Deconvolution (HRD). Designed for the most complex sample matrices, the system enables detection, separation, and confident identification of more analytes than ever before. </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/41"><strong>ChromaTOF® software</strong></a><strong>, purpose-built for HRT+ instrumentation and GC×GC workflows, integrates advanced qualitative and quantitative tools into a single, user-friendly data system.</strong></p><h3><strong>Key Features</strong></h3><ul><li><strong>Compact benchtop design</strong> that saves valuable laboratory space</li><li><strong>Industry-leading sensitivity</strong> with proprietary deconvolution algorithms for clean, high-quality spectra</li><li><strong>High acquisition speed</strong> up to 200 spectra/s to properly define ultra-narrow GC×GC peaks (&lt;200 ms)</li><li><strong>Complete historical mass-spectral record</strong> retained for future data mining and reprocessing</li><li><strong>Proven Pegasus reliability and durability</strong> in a modern, space-efficient format</li></ul><h3><strong>GC×GC Performance Explained</strong></h3><p>GC×GC achieves exceptionally high peak capacity by trapping compounds eluting from the first column and reinjecting them into a second column for rapid secondary separation. These second-dimension separations occur within seconds, producing extremely narrow peaks that demand very high spectral acquisition rates. The Pegasus GC-HRT+ 4D meets and exceeds this requirement, enabling robust spectral deconvolution and confident compound identification in highly complex samples.</p><h3><strong>Available Configurations</strong></h3><ul><li><strong>Pegasus GC-HRT+ 4D with Liquid Nitrogen Thermal Modulator</strong></li><li><strong>Pegasus GC-HRT+ 4D with Cryogen-Free Modulator</strong></li></ul><h3><strong>Optional Accessories</strong></h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/82"><strong>L-PAL3 Autosampler</strong></a></li></ul>

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