Thermo Scientific™ Q Exactive™ GC Orbitrap GC-MS/MS System

Next-generation high-resolution GC-MS for confident quantitation and unknown identification

The Q Exactive GC Orbitrap GC-MS/MS system is the first commercial benchtop system to combine gas chromatography with Orbitrap™ high-resolution accurate-mass (HRAM) detection. It offers unrivaled resolving power, sub-ppm mass accuracy, and the quantitation power of triple quadrupole systems — all in untargeted full-scan mode.

Designed for food safety, metabolomics, environmental, clinical, and pharmaceutical labs, this hybrid quadrupole-Orbitrap system brings unmatched performance for both discovery and targeted workflows, with robust EI/CI ionization, smart deconvolution, and intuitive software.

Key Benefits

🎯 High-resolution power for confident detection

• Up to 100,000 resolution (FWHM) at m/z 272
• Sub-1 ppm mass accuracy (internal) in routine full-scan MS
• Accurate detection even in part-per-trillion range
• Resolves coeluting peaks in complex matrices with ease

💡 Unmatched qualitative and quantitative versatility

• EI, PCI, NCI ionization with ExtractaBrite™ source (removable under vacuum)
• Full-scan sensitivity equal to SRM mode of triple quadrupoles
• PRM and MS/MS with HCD collision cell
• Variable electron voltage (VeV) for softer EI and improved identification

🧠 Advanced tools for unknown identification

• Deconvolution software with HRAM fragment interpretation
• Compatibility with NIST/Wiley libraries and HRAM spectral libraries
• Supports TraceFinder™, Compound Discoverer™, and Mass Frontier™

System Capabilities

• Mass range: 30–3000 m/z
• Mass accuracy: <1 ppm RMS (internal), <3 ppm RMS (external)
• Quantitative dynamic range: >10⁶
• In-spectrum dynamic range: >5000:1
• Scan speed: up to 18 Hz @ 12,500 resolution
• Simultaneous detection of up to 10 precursors per scan

Operation & Workflow

• Full MS, SIM, Timed SIM, PRM, polarity switching, DDA
• Automatic gain control (AGC) ensures optimal ion population in Orbitrap
• Easy maintenance with vent-free source and column exchange
• Seamless Xcalibur™ and TraceFinder™ control with automated tuning/calibration

Sample Introduction & Automation

• Compatible with TRACE™ 1310 GC with Instant Connect injectors
• Autosamplers: TriPlus RSH for full automation and microsample workflows
• Direct probes (DEP/DIP) for solid/liquid samples — no venting required

Applications

• Food safety & authenticity (pesticides, packaging migration)
• Metabolomics, environmental & clinical toxicology
• Extractables & leachables, forensics, pharmaceuticals
• Untargeted and targeted multi-analyte screening

Thermo Scientific™ Q Exactive™ GC Orbitrap GC-MS/MS System