EU Regulation 396/2005: Pesticide Residue Testing and the Critical Role of QuEChERS Evaporation in Food Safety

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 4th May 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application note by<strong> Shimadzu, </strong>presentation by <strong>MDCW / JEOL</strong> and technical note by <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. MDCW / JEOL: Flow-Modulated GCxGC-QMS Analysis Without Splitting Off the GC Flow</strong></h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_16_Jensen_11e29d5022.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>This presentation by Kirk Jensen (JEOL USA) explores the feasibility of performing <strong>flow-modulated comprehensive two-dimensional gas chromatography (GC×GC) coupled with quadrupole mass spectrometry (QMS)</strong> without splitting the GC flow, which is traditionally required to protect MS systems from high carrier gas flows. The core concept builds on GC×GC, where compounds are separated using a primary and secondary column connected via a modulator, significantly increasing separation power compared to one-dimensional GC. The presentation contrasts <strong>thermal modulation</strong> (offering sharper peaks and higher theoretical sensitivity but requiring cryogenic cooling) with <strong>flow modulation</strong>, which avoids cryogens, handles volatile analytes well, and is more flexible, but typically demands higher gas flows that standard MS systems cannot tolerate .</p><p>To address this limitation, the study utilizes the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=24&amp;search=JMS-Q1600GC"><strong>JEOL JMS-Q1600GC</strong></a><strong> UltraQuad quadrupole GC-MS system</strong>, which can accept unusually high carrier gas flows (up to ~20 mL/min), enabling direct coupling with a <strong>SepSolve INSIGHT flow modulator</strong> without splitting the effluent . The analytical setup includes dual GC columns (e.g., Zebron ZB-5MSplus for the first dimension and BPX50 for the second), high secondary flow rates (~25 mL/min), and electron ionization (EI) MS detection. Additional system components include optional FID detection, bleed line control, and ChromeSpace software for data processing . This configuration allows full analyte transfer into the MS, eliminating the need for flow splitting and potentially improving detection efficiency.</p><p>Experimental results demonstrate the applicability of this approach to complex mixtures, including a <strong>pesticide mixture containing over 200 compounds</strong> and real-world samples such as perfumes and fuels. The GC×GC-MS system produced detailed two-dimensional chromatograms with high spectral quality, enabling the correct identification of approximately 120 compounds despite relatively moderate spectral match factors . Comparisons at different flow rates (e.g., 25 vs. 50 mL/min) showed that spectral integrity and compound identification remain robust, indicating that higher flow operation does not significantly compromise MS performance.</p><p>In conclusion, the work demonstrates that <strong>flow-modulated GC×GC-QMS without flow splitting is feasible</strong>, provided that the MS system can tolerate high carrier gas flows. While further optimization is needed (e.g., column selection, inlet pressure, and separation conditions), the approach offers a practical alternative to thermal modulation by eliminating cryogens and simplifying operation. Future work will focus on improving sensitivity, optimizing separations, and exploring alternative carrier gases such as hydrogen to reduce costs and expand applicability</p></div></div></div></div></div></div></section><h3><strong>2. Shimadzu: Detailed Hydrocarbon Analysis by Nexis GC-2030 Using ASTM D6730</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00863_en_eb633bc741.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>Detailed compositional analysis of gasoline in accordance with ASTM D6730 is feasible using the Nexis GC-2030.&nbsp;</li><li>By employing PONAsolution, a PONA/DHA analysis software, laborious identification tasks can be reduced, and quantitation calculations and report generation can be performed automatically.</li></ul><p>ASTM D6730 specifies the analysis of hydrocarbons in gasoline and oxygenates such as ethanol, methyl tert-butyl ether (MTBE), and ethyl tert-butyl ether (ETBE) over a boiling point range up to 225 ̊C. Identification and quantification of individual compounds in gasoline are critically important for refinery process control and product quality assurance. In this application news, we report compositional analysis of gasoline conforming to ASTM D6730 using the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexis+GC-2030"><strong>Nexis GC-2030 gas chromatograph</strong></a>. Gasoline typically comprises over 100 hydrocarbons, making identification tasks highly complex; however, PONAsolution, a PONA/DHA analysissoftware,simplifies this process.</p><h4><strong>PONAsolution</strong></h4><p>PONAsolution Ver.6 provides retention index libraries for each relevant standard (ASTM D6730, D6729, D5134, D6733). Identification of n-alkanes automatically corrects the retention times of the remaining several hundred components, thus streamlining the identification process. When only a specific retention region requires adjustment, the two-point identification function is useful (Fig. 1). In the two-point identification procedure, reference and sample chromatograms are compared while assigning corresponding peaks. First, click on an identified component mark in the reference data (Fig. 1, a), then click the matching sample peak (Fig. 1, b). Repeat this for a second pair of peaks. The retention times of components between these two anchor points are then automatically corrected.</p><h4><strong>Conclusion</strong></h4><p>Compositional analysis of gasoline in accordance with ASTM D6730 was performed. The combination of SH PONA Tuning Column and SH-1 PONA main column enabled separation of compounds with closely spaced retention times. Moreover, use of PONAsolution software greatly simplifies complex identification tasks.</p><h3><strong>3. Thermo Fisher Scientific: Fiber optic probes add flexibility to Raman chemical analysis</strong></h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/drx3_flex_tech_note_tn54708_bebb56b870.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Fourier Transform Infrared Spectroscopy (FTIR) and Raman Spectroscopy are non-destructive analytical techniques that rely on the interaction of electromagnetic radiation with molecular vibrations to provide information about the chemical composition and structure of a sample. Despite their similarities, there are some distinct differences between the two techniques. In principle, FTIR is based on the absorption of infrared radiation by molecules and measures changes in dipole moment during molecular vibrations. Raman spectroscopy, on the other hand, is based on the inelastic scattering of monochromatic light and measures changes in polarizability during molecular vibrations.&nbsp;</p><p>When applied to bulk chemical analysis, both FTIR and Raman spectroscopy can be used to analyze solids, liquids, and gases, but the nature of Raman spectroscopy lends some unique sampling advantages. Additionally, Raman often requires little to no sample preparation. Presented herein are application examples that highlight some of the sampling advantages of Raman spectroscopy. All the spectral data in this technical note were collected using a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2238"><strong>Thermo Scientific™ DXR3 Flex Raman Spectrometer</strong></a> equipped with a fiber optic probe. (Fiber optics are readily available for Raman spectroscopy because of the use of visible and NIR light and do not require the exotic materials associated with FTIR fiber optics.) Preliminary tests for all samples were carried out using both 532 nm and 785 nm excitations, and it was determined that the 785 nm laser set gave an overall better balance between fluorescence and Raman scattering efficiency.</p><h4><strong>Summary&nbsp;</strong></h4><p>In this technical note, the analyses of a variety of samples by Raman spectroscopy are demonstrated. All samples were analyzed without sample preparation.&nbsp;</p><ul><li>Precise and localized analysis at the focal point of the Raman-exciting laser allows sampling through glass bottles, blister packaging and plastic containers, which eliminates possible cross contamination and analyst exposure to hazardous materials. The contributions from the packaging and containers depend on the type of container material, the container thickness, and the materials’ chemical compositional complexity, but these contributions can be readily subtracted out when needed.&nbsp;</li><li>Water is a weak Raman scatterer. Raman therefore has reduced water sensitivity, making it a preferred technique for aqueous solution analysis over FTIR. As demonstrated in the analysis of an energy drink, the Raman bands from water can be subtracted from the spectrum of the aqueous solution, leading to the identification of the components of the solution.&nbsp;</li><li>Raman spectroscopy is well suited for the analysis of inorganic materials, especially in identifying the crystal phases and polymorphs, as demonstrated by the analyses of minerals and pigments in a painting.&nbsp;</li><li>Fiber optic probes provide flexibility and ease of maneuverability. This is particularly advantageous when analyzing samples that are difficult to access or manipulate, such as large containers, geological samples and paintings</li></ul><p>The DXR3 Flex has multiple sampling options available. A properly configured fiber-optic probe is arguably the most versatile accessory for the analysis of bulk solids and liquids. The advantages, both from those inherent to Raman spectroscopy and those resulting from the use of fiber optic probe, provide opportunities for a wide variety of different applications when using the DXR3 Flex Raman Spectrometer.</p>

News from LabRulezGCMS Library - Week 19, 2026

<p><strong>🎤Francis Femi Oloy</strong></p><p><strong>In this episode of Concentrating on Chromatography, David speaks with Francis Femi Oloy about using chromatography to uncover hidden pollutants in real-world water systems.</strong></p><p>Femi’s team analyzed polychlorinated biphenyls (PCBs) in six major rivers in southwestern Nigeria — compounds that were banned decades ago but still persist in the environment. Using a workflow that many analytical labs will recognize — liquid–liquid extraction, cleanup, rotary evaporation, nitrogen blowdown, and GC-ECD detection — they quantified 25 PCB congeners at trace levels and linked the results to ecological and human health risk.</p><h4><strong>In this conversation, we cover:</strong></h4><ul><li>Why legacy pollutants like PCBs still show up today</li><li>Choosing GC-ECD vs LC-MS for halogenated compounds</li><li>Liquid–liquid extraction and matrix cleanup strategies</li><li>Why sample concentration is critical for dilute environmental samples</li><li>How rotovap + nitrogen blowdown work together without losing volatile analytes</li><li>Seasonal trends (why wet season levels were higher)</li><li>Translating concentration data into meaningful risk assessments</li></ul><h3><strong>Video Transcription</strong></h3><section><div><div><div><div><div><div><p><strong>Persistent organic pollutants</strong> such as polychlorinated biphenyls (<strong>PCBs</strong>) remain a significant environmental concern despite decades of regulatory restrictions. In this interview, Francais Femi Oloy discusses the environmental and analytical challenges associated with monitoring PCB contamination in rivers of southwestern Nigeria, a rapidly industrializing region where urban growth, industrial activity, agriculture, and dense populations intersect with extensive aquatic systems.</p><p>Oloy explains that his interest in environmental contaminant analysis emerged from observing unexplained health problems and environmental degradation while growing up in Nigeria. This motivated his transition into organic and environmental chemistry, with a focus on identifying pollutants present in drinking water, agricultural soils, and food systems. Southwestern Nigeria, particularly the Lagos region, represents a critical environmental monitoring area due to intense industrial development, shipping activity, and widespread human dependence on rivers for domestic use, agriculture, and fishing.</p><p>Although PCBs are considered “<strong>legacy pollutants</strong>” and are no longer intentionally produced, the interview highlights why they continue to persist in aquatic environments. Old electrical transformers and aging industrial equipment still contain PCB residues, while historical contamination stored in river sediments can become remobilized during flooding, dredging, or sediment disturbance. Because PCBs are hydrophobic and resistant to degradation, they preferentially accumulate in sediments and bioaccumulate through aquatic food chains, creating long-term environmental and human exposure risks.</p><p>A major focus of the discussion centers on the analytical workflow used for PCB determination in environmental water samples. Composite river water samples were collected in amber glass bottles to avoid contamination and photodegradation, preserved with sodium azide to minimize microbial activity, and stored under cooled conditions prior to extraction. The analytical protocol employed <strong>liquid–liquid extraction</strong> using dichloromethane (DCM) and hexane to recover both polar and nonpolar PCB congeners. Oloy emphasizes that liquid–liquid extraction was selected over solid-phase extraction (SPE) because of concerns about congener retention within sorbent materials and clogging issues associated with large-volume environmental samples.</p><p>Following extraction, concentration and cleanup represented critical analytical stages due to the trace-level occurrence and volatility of PCBs. Silica and alumina cleanup procedures were used to remove matrix interferences prior to instrumental analysis. The concentration workflow combined rotary evaporation for bulk solvent reduction with nitrogen blowdown for final volume reduction to less than 1 mL, while carefully avoiding excessive temperature or complete dryness to minimize analyte loss. Oloy repeatedly stresses that improper concentration procedures are among the most common causes of analytical failure in PCB analysis.</p><p>For instrumental determination, the study utilized <strong>gas chromatography coupled with electron capture detection (GC-ECD)</strong> rather than LC-MS or GC-MS. According to Oloy, GC was preferred because PCBs are sufficiently volatile for gas chromatographic separation, while ECD provided superior sensitivity and selectivity for chlorinated compounds at environmentally relevant concentrations. The interview also discusses analytical validation strategies, including the use of surrogate standards to assess <strong>recoveries,</strong> which ranged from approximately <strong>85% to 114%</strong>, and signal-to-noise-based determination of detection limits.</p><p>The study further examined <strong>seasonal variations in PCB concentrations</strong>, revealing <strong>higher levels during the wet season</strong>. This observation was attributed to rainfall-driven runoff from contaminated infrastructure, sediment resuspension, and lower temperatures that reduce volatilization losses. To communicate toxicological relevance beyond simple concentration reporting, the researchers also calculated <strong>toxic equivalency values (TEQs)</strong>, converting mixtures of PCB congeners into biologically meaningful toxicity estimates comparable to dioxin toxicity metrics.</p><p>Beyond environmental monitoring, Oloy highlights broader research interests focused on <strong>pollutant remediation and sustainable environmental protection</strong>. His group is also involved in developing catalytic materials capable of degrading or removing persistent contaminants from environmental systems. Throughout the discussion, he emphasizes that analytical chemistry plays a central role not only in detecting pollutants, but also in enabling prevention, remediation, and long-term environmental management strategies.</p></div></div></div></div></div></div></section><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

Tracking Toxic PCBs in River Water using Gas Chromatography–Electron Capture Detection

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<p>New technologies and methods are continually pushing the field of metabolomics by expanding the metabolite landscape interrogated within a single sample. One exciting approach is to exploit and integrate the orthogonality of both liquid chromatography (LC) and gas chromatography (GC), coupled to high-resolution mass spectrometers, into a metabolomics workflow. In this presentation, Dr. John A. Bowden, Assistant Professor in the Department of Physiological Sciences in the College of Veterinary Medicine at the University of Florida, will examine a diverse suite of reference materials using a multi-platform metabolomics approach. Utility of the multi-platform metabolomics approach will be explored for the analysis of a novel in vitro gastrointestinal model to assess the effects of ubiquitous chemicals on the microbiome. Measurement of emerging volatile per- and polyfluoroalkyl substances (PFAS) will also be discussed.</p>
<h3><strong>Key learning objectives:</strong></h3>
<ul>
<li>Learn how to implement metabolomics experiments for both gas chromatography and liquid chromatography mass spectrometry using the Thermo Scientific Orbitrap Exploris GC 240 mass spectrometer and Thermo Scientific Q-Exactive Orbitrap mass spectrometer</li>
<li>Learn how high-resolution accurate mass data can provide broader coverage and a deeper understanding of samples, including detection of merging compounds</li>
<li>Learn how in vitro techniques can be used to assess the effects of ubiquitous chemicals on the microbiome</li>
</ul>
<h3><strong>Who should attend?</strong></h3>
<ul>
<li>Research scientists with a focus on metabolomics, exposomics and emerging contaminants</li>
<li>Analytical chemists</li>
<li>Laboratory managers</li>
<li>Gas and liquid chromatography mass spectrometry users</li>
</ul>
<blockquote>
<p><strong>Presenter: Dr. John Bowden (Assistant Professor, University of Florida)</strong></p>
</blockquote>
<blockquote>
<p>Dr. John A. Bowden is an Associate Professor in the Department of Physiological Sciences in the College of Veterinary Medicine at the University of Florida (UF). He also has a joint appointment in the Department of Chemistry and has affiliations with the Center for Human and Environmental Toxicology and the Engineering School of Sustainable Infrastructure &amp; Environment. He received his Ph.D. in analytical chemistry from UF under the guidance of Dr. Richard A. Yost in 2009. After a two-year postdoctoral fellowship at Saint Louis University, he joined the National Institute of Standards and Technology (NIST) as an NIST/NRC postdoctoral fellow in 2011, working at the Hollings Marine Laboratory in Charleston, SC, where he would later serve as a research chemist until 2018. In his current position, his research is focused on employing novel mass spectrometric methods at the chem/bio interface, with an expanding interest in the fields of metabolomics, lipidomics and exposomics.</p>
</blockquote>
<blockquote>
<p><strong>Presenter: Dr. Juan Henao (Lipidomics Scientist, BERG Health)</strong></p>
</blockquote>
<blockquote>
<p>Dr. Juan Henao is a Lipidomics Scientist at BERG Health in Framingham, MA, USA. He completed his PhD at the University of Waterloo in Nutritional Lipidomics with Dr. Ken Stark, as well as a Postdoctoral position at the University of Florida with Dr. John Bowden. Juan’s expertise is in method development using LCMS and GCMS for lipidomics, metabolomics and environmental contaminants. </p>
</blockquote>
<blockquote>
<p><strong>Moderator: Sarah Thomas (Editorial Team, SelectScience)</strong></p>
</blockquote>
<blockquote>
<p>Sarah studied biology at the University of Bath, UK, and has worked in the Pharmaceutical Sciences Department of St. Jude Children’s Research Hospital, Memphis. As a member of the Editorial team, Sarah plays an integral role in shaping the content on SelectScience.</p>
</blockquote>


SelectScience: A multi-platform metabolomics approach for exposure science using mass spectrometry

A multi-platform metabolomics approach for exposure science using mass spectrometry

<p><strong>In this tutorial, Fernanda Rey-Stolle and Prof. Antonia Garcia from the Centre of Excellence in Metabolomics and Bioanalysis (CEMBIO) will discuss:</strong></p>
<ul>
<li>GC-MS versus other analytical techniques for metabolic profiling</li>
<li>Main steps in the metabolomics workflow</li>
<li>Type of biological samples and strategies for volatile derivatives</li>
<li>Internal standards, why and how many?</li>
<li>Pre-processing data and identification: deconvolution, libraries &amp; retention index</li>
<li>Quantification. Discussion of particular aspects, target ion and multiple derivatives</li>
<li>Applications in health and disease</li>
<li>High resolution vs low resolution MS. Strengths for identification of unknowns. A case study.</li>
</ul>
<blockquote>
<p><strong>Presenter: Antonia García (Professor of Analytical Chemistry at Pharmacy Faculty, San Pablo CEUUniversity, Madrid)</strong></p>
</blockquote>
<blockquote>
<p>She is currently Professor of Analytical Chemistry at Pharmacy Faculty, Universidad San Pablo CEU, Madrid (Spain) and cofounder members of the Centre for Metabolomics and Bioanalysis of San Pablo CEU University (Madrid, Spain) in 2008. Her research has been focused on development and validation of chromatographic methods for metabolomics based on mass spectrometry multiplatforms (LC, CE and GC) in the study of several diseases such as cancer, diabetes, obesity, infectious, lung and cardiovascular diseases. 8 supervised theses. National and international grants as PI. Journal of Pharmaceutical and Biomedical Analysis Editorial Board member.</p>
</blockquote>
<blockquote>
<p><strong>Presenter: Fernanda Rey-Stolle (Senior Lecturer and Researcher, San Pablo CEU University, Madrid)</strong></p>
</blockquote>
<blockquote>
<p>She is senior lecturer and researcher at San Pablo CEU University since 1994. Since 2013 she is a member of CEMBIO (Centre of Excellence in Metabolomics and Bioanalysis), focusing her research on the application of the GC-MS technique to metabolomic studies. She has participated in 16 Projects and/or Research Contracts, in 2 of them as PI. She is coauthor of 43 articles and has presented more than 50 oral communications and posters in relevant International Congresses. She has been a member of the scientific/organizing committee of 9 International and National congresses.</p>
</blockquote>


Agilent Technologies: Low and High Resolution GCMS for Untargeted Metabolomics

Low and High Resolution GCMS for Untargeted Metabolomics

We will discuss: GC-MS versus other analytical techniques for metabolic profiling,  Main steps in the metabolomics workflow, Type of biological samples...

<p><strong>Reaching further in your metabolomics study with IC, GC and LC-MS analysis.</strong></p>
<p>The comprehensive analysis of small endogenous and exogenous molecules in a biological system results in a better understanding of metabolomic processes. The characterization of metabolic phenotypes enables biomarker discovery, disease taxonomy, and tracking treatment effects. </p>
<p>The metabolomic challenge includes a large number of compounds with diverse physicochemical properties. This leads to new analytical challenges when a more comprehensive coverage of the metabolic landscape is needed.</p>
<p>High-resolution accurate mass measurement (HRAM) mass spectrometry (MS) is an essential tool in metabolome analysis. Thermo Scientific Orbitrap-based mass spectrometers provide a leading combination of sensitivity, mass accuracy, and resolving power that helps answer the most challenging analytical tasks.</p>
<p>MS, however, suffers from disadvantages such as ion suppression and the differentiation of isomers. The combination of MS with separation techniques addresses such issues. Different chromatographic approaches can be used and fine-tuned to a specific set of metabolites, including polar and ionic compounds, glycans, volatile compounds, and steroids. The comprehensive analysis of the metabolome, however, requires a combination of this method.</p>
<h3><strong>We will present three topics:</strong></h3>
<ul>
<li>The untargeted screening workflow for identification and comparison of different wine origin using the GC Orbitrap technology and Compound discoverer,</li>
<li>The combination of Ion Chromatography (IC) with HRAM to determine polar and ionic components, </li>
<li>A HPLC-Orbitrap example study to showing the changes observed in mice plasma composition depending on the diet type.</li>
</ul>
<p>All experimental data were processed with the Thermo Scientific Compound Discoverer software, to comprehensively profile the samples, detect more compounds, and identify unknowns. </p>
<p>We will introduce our newest member of the LC-MS family, the Thermo Scientific Orbitrap Exploris mass spectrometer.</p>
<h3><strong>What you will learn:</strong></h3>
<ul>
<li>MS instrumentation designed for exceptional usability resulting in increased productivity in metabolomics</li>
<li>Benefits of high-resolution accurate mass spectrometry (HRAM) in unknown analysis and research</li>
<li>Analytical solutions for sample profiling</li>
<li>Examples of complete IC-MS, GC-MS, and LC-MS workflows for unknown identification using Orbitrap technology and Compound Discoverer software</li>
</ul>
<blockquote>
<p><strong>Presenter: Anas Kamleh (Expert Sales Support, Metabolomics, Thermo Fisher Scientific)</strong></p>
</blockquote>
<blockquote>
<p>Anas joined Thermo Fisher Scientific in 2015 as an application specialist in metabolomics. He is driving a new role since 2018 that entitles supervising collaboration projects and ensuring our hardware and software products provide the best experience for Orbitrap metabolomics users. His industrial and academic background extend to close to 15 years of experience in the field of metabolomics spanning a PhD thesis from University of Strathclyde, Scotland and postdoctoral research positions at Imperial College London and Karolinska Institutet in Stockholm, Sweden.</p>
</blockquote>
<blockquote>
<p><strong>Presenter: Racha Mailler (Sales Support Specialist GCMS/MS, EFS-Industrial, Thermo Fisher Scientific)</strong></p>
</blockquote>
<blockquote>
<p>Racha joined Thermo Fisher Scientific in 2016 as Technical support specialist for GC and GC/MS. She is driving a new role since 2018 as an application specialist for GC, GCMS and Orbitrap technologies. Her role has expand to cover EMEA zone. Her everyday job is to help our GCMS users getting the best out of their instrument by training them on the software and advising them with the method development. Racha holds a PhD degree in Analytical chemistry from the university of Lille 1.</p>
</blockquote>
<blockquote>
<p><strong>Presenter: Detlef Jensen (Sr. Expert, SST, EFS-Industrial, Thermo Fisher Scientific)</strong></p>
</blockquote>
<blockquote>
<p>Detlef holds a Ph.D. in Chemistry from the Technical University Berlin/Germany. For more than 30 years, he covered many positions at Dionex, now Thermo Fisher Scientific in ion chromatography. Since March 2013, he has been supporting our users and field teams all over Europe in his role as European Ion Chromatography Expert.</p>
</blockquote>


Thermo Scientific: Omics Winter Webinars - Metabolomics session 4: Chromatographic solutions

Metabolomics session 4: Chromatographic solutions

<div><h3><strong>Decoding Metabolic Responses in Complex Biology</strong></h3><p><strong>Join us for our latest webinar introducing ecTOF for life sciences applications. This next‑generation GC‑MS platform is designed to expand metabolite coverage and improve unknown annotation in complex samples.</strong></p><p>Most GC‑MS systems force you to pick between EI (great fragmentation, sometimes ambiguous IDs) and CI (better molecular ion, complementary information). The ecTOF acquires EI and CI data simultaneously in a single analysis, giving you more mass spectrometric evidence for each compound without extra runs or compromises.</p><h4><strong>What this means for your lab:</strong></h4><ul><li><strong>Detect more metabolites</strong> including those missed by EI‑only</li><li><strong>Increase confidence</strong> in spectral library matches and annotations</li><li><strong>Reduce false positives</strong> and speed up unknown triage</li><li><strong>Boost throughput</strong> with richer data per injection</li></ul><p>In this webinar, our esteemed speakers Dr. Volker Behrends and Dr. Sonja Klee will show how <strong>GC-MS-based profiling including novel ecTOF-based analysis was applied to assess the impact of MRSA infection on host central carbon metabolism</strong> with or without treatment.</p><p>We’ll walk through how GC-MS and specifically the ecTOF helps characterize metabolite shifts in a challenging cell model (A549 cells infected with S. aureus USA300 LAC and treated with different drugs), showing how EI+CI improves identification confidence and expands the detectable chemical space. The same principles and workflows apply broadly to host–pathogen studies, drug metabolism, toxicology, and systems biology.</p><p><strong>Discover how in even complex samples, ecTOF’s parallel EI+CI data enables clearer annotations and deeper biological interpretation.</strong></p><h4><strong>Key Learning Objectives</strong></h4><ul><li>How dual EI+CI in one run increases metabolite coverage and improves unknown identification</li><li>Practical ways to reduce ambiguity in spectral matching and raise confidence in annotations</li><li>How ecTOF integrates with existing GC methods, with no need to choose between EI or CI</li><li>Real‑world results from complex biological samples, with takeaways that translate to any GC‑MS metabolomics workflow</li></ul><h4><strong>Who Should Attend</strong></h4><ul><li>Life science researchers investigating complex molecular mechanisms in biological context</li><li>Metabolomics researchers expanding beyond targeted panel measurements</li><li>Exposomics and environmental health scientists mapping biological responses to broad and potentially undiscovered chemical stimuli.</li><li>Toxicology, food, and fragrance labs seeking broader chemical coverage</li><li>Core facilities &amp; omics method developers modernizing GC‑MS capability</li><li>LC‑MS users who want complementary coverage for better coverage of the metabolome</li></ul><blockquote><p><strong>Presenter:</strong> Dr. Volker Behrends, Ph.D., Associate Professor of Microbial Metabolism, School of Medicine and Biosciences, University of West London, London, UK</p><p>Dr. Volker Behrends is Associate Professor of Microbial Metabolism in the School of Medicine and Biosciences at the University of West London. His research focuses on how bacterial pathogens remodel host environments, using GC-MS–based metabolomics to track metabolite dynamics during infection. His group integrates microbial physiology with quantitative metabolomics to map metabolic fluxes and investigate how repurposed drugs alter pathogen behavior and host–pathogen interactions.</p><p><strong>Presenter: </strong>Dr. Sonja Klee, Product Manager ecTOF, TOFWERK, Thun, Switzerland</p><p>Dr .Sonja Klee is the product manager for the ecTOF platform at TOFWERK AG in Thun, Switzerland. She obtained her Ph.D. in physical chemistry from the University of Wuppertal. She was awarded a Wolfgang Pauli Study Award from the DGMS and was a Marie Curie Fellow at the CLOUD TRAIN network at CERN. She is a board member of the Swiss Group Mass Spectrometry (DGMS) and a member of the steering committee for BP4NTA (BestPractice4NonTargetAnalysis) working group.</p></blockquote></div>

Bruker: ecTOF: Advancing Metabolomics with Next‑Generation GC‑HRMS and Dual EI+CI Insight

ecTOF: Advancing Metabolomics with Next‑Generation GC‑HRMS and Dual EI+CI Insight

Discover how simultaneous EI + CI acquisition on ecTOF unlocks metabolome coverage and more annotation for untargeted and semi-targeted GC‑MS workflows

GCMS webinars focusing on GC/MS/MS, OMICS - page 1