<p><strong>Clarity 10.2 expands instrument control capabilities with new control modules and updates the MS extension to help you work more efficiently.</strong></p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity</strong></a><strong> 10.2 highlights</strong></h4><ul><li>New and updated control modules</li><li>Improved MS data import and export</li><li>Obsolete hardware support ended</li></ul><h4><strong>Instrument control modules</strong></h4><p>Clarity 10.2 introduces new instrument control modules from Annuo (AS-3117, FAS-3823) and updated instrument controls form Sykam and Ecom.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Instrument_control_modules_5de26782b0.jpg" alt="DataApex: Instrument control modules" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Instrument_control_modules_5de26782b0.jpg 228w," sizes="100vw" width="380" height="260"></p><h4><strong>MS data import/export improvements</strong></h4><p>Clarity improves MS data exchange, especially for *.cdf files. MS instruments now support export and import of multiple spectral data and non-spectral signal data in the same CDF file. Import also better handles uniform sampling information, m/z Step values, scale factors, and file names with non-ASCII characters. Exporting individual chromatogram signals from MS instruments is now available through a separate Export Chromatogram dialog.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg" alt="DataApex: MS data import-export improvements" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg 228w," sizes="100vw" width="378" height="259"></p><h4><strong>Obsolete hardware support terminated</strong></h4><p>Due to changes in Windows driver security requirements, this update discontinues support for obsolete hardware, including INT7, INT9, U-PAD, U-PAD2, and CB20.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg" alt="DataApex: Obsolete hardware support terminated" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg 228w," sizes="100vw" width="378" height="259"></p><blockquote><p><strong>Explore the complete list of all changes, fixes, and additions in version 10.2.</strong></p><p><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1"><strong>See the complete changelog&nbsp;</strong></a></p></blockquote>

Clarity Chromatography Software 10.2 released!

<p><strong>This study describes the development and validation of a dual-column, dual-detector HS-GC-FID/FID method for the forensic analysis of ethanol and other low-molecular-weight volatile compounds in biological samples. The method demonstrated excellent linearity, low detection limits, high precision, and accuracy, and was successfully verified through international proficiency testing.</strong></p><p>In addition to routine forensic application, the study reviews current practices in forensic alcohol analysis and highlights the lack of globally harmonized analytical standards. The authors propose essential methodological recommendations to improve the reliability and evidential value of ethanol determination in forensic toxicology.</p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.mdpi.com/2039-4713/16/3/80"><strong>Dual-Column HS-GC-FID/FID Method for In-Depth Analysis of Low-Molecular-Weight Volatile Alcohols in Postmortem Biological Material&nbsp;</strong></a></h4><p>Paweł Szpot, Olga Wachełko, Kaja Tusiewicz and Marcin Zawadzki</p><p>J. Xenobiot. 2026, 16(3), 80</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.3390/jox16030080">https://doi.org/10.3390/jox16030080</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><p><strong>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.</strong></p><div><p>The determination of low-molecular-weight volatile alcohols in <span>postmortem</span> material using headspace gas chromatography (HS-GC) is routinely performed in forensic laboratories. These analyses are important not only for law enforcement agencies in the broad sense, but also for insurance companies that decide on the payment of compensation under insurance policies. Typically, routine determination of alcohols such as methanol, ethanol, isopropanol, n-propanol, and n-butanol is sufficient to establish whether death occurred as a result of poisoning with these substances. In forensic toxicology practice, however, there are also situations in which the determination of additional chemical compounds in biological material proves to be essential. One such compound is acetone, the determination of which is crucial not only in cases of acetone or isopropanol poisoning (since acetone is a metabolite of the aforementioned alcohol) [<a target="_blank" rel="noopener noreferrer" href="https://www.mdpi.com/2039-4713/16/3/80#B1-jox-16-00080">1</a>], but also in the diagnosis of ketosis caused by diabetes, hypothermia, or starvation [<a target="_blank" rel="noopener noreferrer" href="https://www.mdpi.com/2039-4713/16/3/80#B2-jox-16-00080">2</a>]. Criminal cases can be complex, and therefore, to achieve a better understanding of the circumstances preceding death, toxicological analyses are sometimes extended to also include other compounds, such as acetaldehyde [<a target="_blank" rel="noopener noreferrer" href="https://www.mdpi.com/2039-4713/16/3/80#B3-jox-16-00080">3</a>].</p><p><span>Postmortem</span> blood toxicological analysis is of particular importance because it plays a key role in determining the cause of death, especially in cases of unexplained sudden death and deaths occurring under suspicious circumstances. Even a simple screening for volatile chemical compounds can, at an early stage, allow determination of whether death resulted from poisoning or was a consequence of an underlying disease suffered by the deceased (e.g., untreated diabetes) [<a target="_blank" rel="noopener noreferrer" href="https://www.mdpi.com/2039-4713/16/3/80#B4-jox-16-00080">4</a>].</p><p>One of the fundamental assumptions in forensic toxicological investigations is that their results must have evidential value and withstand scrutiny in court. Only such results can be used, for example, to reconstruct the circumstances preceding death, determine the time of substance intake or the dose of a toxic agent, or assess whether the deceased was intoxicated. This is particularly important in cases of traffic accidents, occupational accidents, drownings, domestic violence, and deaths occurring during police custody. It is worth emphasizing that the interpretation of <span>postmortem</span> toxicological results requires particular caution due to the multitude of “confounding” factors, such as interindividual variability, substance stability, endogenous formation, the postmortem interval (PMI), and the circumstances of death. To avoid introducing additional variables that could further complicate interpretation, the applied analytical method must be reliable, i.e., accurate, selective, resistant to interference, and preferably verified through independent proficiency testing [<a target="_blank" rel="noopener noreferrer" href="https://www.mdpi.com/2039-4713/16/3/80#B5-jox-16-00080">5</a>].</p><p>In gas chromatographic analysis of low-molecular-weight alcohols, either direct injection or the headspace technique is employed [<a target="_blank" rel="noopener noreferrer" href="https://www.mdpi.com/2039-4713/16/3/80#B6-jox-16-00080">6</a>]. In the past, even highly invasive approaches were used, such as the direct injection of whole blood into the gas chromatograph injector [<a target="_blank" rel="noopener noreferrer" href="https://www.mdpi.com/2039-4713/16/3/80#B7-jox-16-00080">7</a>]. However, the headspace technique has become the most widely used technique for the determination of alcohols in forensic laboratories. This preference can be attributed to several well-established advantages, most notably that the method allows the sample to be analyzed with minimal or no preparatory steps, irrespective of the biological matrix (e.g., without extraction or protein precipitation). Additional benefits include practically negligible matrix effects, elimination of the need for inlet liners, thereby minimizing the risk of contamination or carryover within the analytical system, and reduced deterioration of the chromatographic column compared with direct injection.</p><p>However, it should be noted that in the context of postmortem samples (particularly those collected from putrefied cadavers), the impact of decomposition on analyte partitioning cannot be precisely assessed. While headspace analysis generally exhibits negligible matrix effects, pre-death specimens from the same individual are rarely available for direct comparison, making it difficult to determine the extent to which postmortem changes might influence measurements. Moreover, the blood samples are subjected to multiple dilutions with an internal standard, which further minimizes potential matrix effects.</p><p>Despite numerous established methods for the determination of volatile alcohols in postmortem biological samples, current standard approaches often face limitations that can compromise forensic reliability. Single-column analyses may be prone to co-elution and interferences from structurally similar compounds, while reliance on a single detector increases the risk of undetected fluctuations and errors. Additionally, inappropriate selection of internal standards and postmortem formation of endogenous alcohols and other volatile compounds can further bias quantification. These issues highlight a critical gap, as widely adopted methods that integrate redundant analytical controls with validated procedures to minimize errors and ensure evidential reliability remain limited.</p><p>The aim of this study was to develop a method for the determination of methanol, acetone, ethanol, n-propanol, isopropanol, and n-butanol using headspace gas chromatography with dual columns and dual-flame ionization detectors. The practical applicability of the method was demonstrated using authentic forensic samples, including putrefaction fluid and antemortem blood. This study addresses the aforementioned gap by employing a dual-column/dual-FID approach, which allows cross-verification across two independent chromatographic conditions, thereby enhancing both the accuracy and reproducibility of forensic alcohol analysis. Furthermore, this paper aims to draw the attention of toxicologists worldwide to several critical factors that can significantly influence measured ethanol concentrations, potentially leading to legal and financial consequences, such as denial of compensation due to falsely elevated ethanol levels.</p><h4><strong>2. Materials and Methods</strong></h4><h5><strong>2.4. Apparatus</strong></h5><p>A <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=2010"><strong>Shimadzu GC-2010</strong></a> Plus AF IVD system (Kyoto, Japan), fitted with an advanced flow controller (AFC), a split/splitless (SPL) inlet, and two flame ionization detectors (FID), was employed. Samples were processed and introduced via a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=HS-20"><strong>Shimadzu HS-20 static headspace autosampler</strong></a> (Kyoto, Japan), with transfer to the GC through a single SPL inlet. The HS effluent was split equally (1:1) using a SilFlow<sup>®</sup> microfluidic platform (SHI-980-10593, Trajan, Ringwood, VIC, Australia) and directed onto two capillary columns: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=50&amp;search=Zebron-BAC1"><strong>Zebron-BAC1</strong></a> (30 m × 0.32 mm i.d., 1.8 μm film; Phenomenex, Torrance, CA, USA) and Zebron-BAC2 (30 m × 0.32 mm i.d., 1.2 μm film; Phenomenex, Torrance, CA, USA). Each column fed an independent FID channel, allowing concurrent acquisition from both separations. Headspace settings and chromatographic conditions for alcohol congener analysis followed those reported previously in [<a target="_blank" rel="noopener noreferrer" href="https://www.mdpi.com/2039-4713/16/3/80#B8-jox-16-00080">8</a>].</p><h4><strong>3. Results</strong></h4><p>Validation results are shown in <a target="_blank" rel="noopener noreferrer" href="https://www.mdpi.com/2039-4713/16/3/80#table_body_display_jox-16-00080-t002">Table 2</a>. All presented values fall within the acceptable range for toxicological analysis of biological materials, in accordance with the recommendations of the German Society of Toxicological and Forensic Chemistry (GTFCh) [<a target="_blank" rel="noopener noreferrer" href="https://www.mdpi.com/2039-4713/16/3/80#B10-jox-16-00080">10</a>]. Quality-control samples were prepared at three concentrations (low, medium, and high relative to the calibration range) by spiking blank samples. Relative error (RE) values within ±15% and precision expressed as relative standard deviation (RSD) ≤ 15% were considered acceptable, in accordance with GTFCh recommendations. The method, developed in 2019, has been subjected to international proficiency testing for ETB Ethanol in blood (ARVECON) and has consistently achieved positive results in each test. Additionally, the developed method for the determination of ethyl alcohol in blood was evaluated and achieved positive results in other proficiency tests, namely: the AXIO LGC Proficiency Testing Scheme in Drugs in blood Quantitative analyte selection, PT-TX-BLD (accreditation ISO/IEC 17043) (LGC Group Limited, Guildford, UK). Furthermore, the HS-GC-FID/FID method has been successfully implemented for routine toxicological analysis in our laboratory during the past 6 years.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/J_Xenobiot_2026_16_3_80_Table_2_Validation_results_for_six_quantified_volatile_compounds_methanol_ethanol_acetone_isopropanol_n_propanol_and_n_butanol_64ddd30e8d.jpg" alt="J. Xenobiot. 2026, 16(3), 80: Table 2. Validation results for six quantified volatile compounds: methanol, ethanol, acetone, isopropanol, n-propanol, and n-butanol. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_J_Xenobiot_2026_16_3_80_Table_2_Validation_results_for_six_quantified_volatile_compounds_methanol_ethanol_acetone_isopropanol_n_propanol_and_n_butanol_64ddd30e8d.jpg 180w," sizes="100vw" width="1238" height="1073"></p><p>Chromatograms of all compounds analyzed using the presented method, collected on two columns (Zebron ZB-BAC1 and Zebron ZB-BAC2), are shown in <a target="_blank" rel="noopener noreferrer" href="https://www.mdpi.com/2039-4713/16/3/80#fig_body_display_jox-16-00080-f001">Figure 1</a>. During routine toxicological examinations, we analyzed various biological fluids, including standard matrices such as whole blood, serum, plasma, vitreous humor, and urine, as well as less commonly studied matrices such as bile, putrefaction fluid, and gastric contents.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/J_Xenobiot_2026_16_3_80_Figure_1_Chromatograms_of_ISTD_and_LOQ_of_volatile_compounds_obtained_from_two_columns_3826b6b870.jpg" alt="J. Xenobiot. 2026, 16(3), 80: Figure 1. Chromatograms of ISTD and LOQ of volatile compounds obtained from two columns (Zebron ZB-BAC1 and Zebron ZB-BAC2) and two flame ionization detectors. The retention time of tert-butanol (ISTD) on the first column was 2.848, and on the second it was 3.131. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_J_Xenobiot_2026_16_3_80_Figure_1_Chromatograms_of_ISTD_and_LOQ_of_volatile_compounds_obtained_from_two_columns_3826b6b870.jpg 236w," sizes="100vw" width="1600" height="1056"></p><p>Chromatograms from representative authentic cases are shown in <a target="_blank" rel="noopener noreferrer" href="https://www.mdpi.com/2039-4713/16/3/80#fig_body_display_jox-16-00080-f002">Figure 2</a>, including putrefaction fluid (containing 0.4‰ of ethanol) compared with a standard whole blood sample containing 1.38‰ ethanol.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/J_Xenobiot_2026_16_3_80_Figure_2_A_Chromatograms_of_putrefaction_fluid_with_ethanol_concentration_of_0_4_B_chromatograms_of_antemortem_blood_sample_with_ethanol_concentration_of_1_38_fe782ce3d1.jpg" alt="J. Xenobiot. 2026, 16(3), 80: Figure 2. (A) Chromatograms of putrefaction fluid (with ethanol concentration of 0.4‰); (B) chromatograms of antemortem blood sample (with ethanol concentration of 1.38‰). Results were provided for both columns: Zebron ZB-BAC1 and Zebron ZB-BAC2." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_J_Xenobiot_2026_16_3_80_Figure_2_A_Chromatograms_of_putrefaction_fluid_with_ethanol_concentration_of_0_4_B_chromatograms_of_antemortem_blood_sample_with_ethanol_concentration_of_1_38_fe782ce3d1.jpg 245w," sizes="100vw" width="1600" height="453"></p><h4><strong>5. Conclusions</strong></h4><p>The findings presented in this study demonstrate that reliable forensic determination of ethanol and other volatile compounds requires a comprehensive analytical strategy that extends beyond routine instrumental analysis. Despite the long-standing use of alcohol determinations in forensic practice, significant methodological limitations persist, particularly with respect to selectivity, internal standard selection, and control of pre-analytical and analytical variables. Based on a critical evaluation of currently published methods and supported by experimental evidence and authentic forensic casework, several key methodological principles emerge as essential for ensuring the evidential reliability of ethanol analysis in forensic toxicology. These principles are summarized below:</p><div><ul><li>Using two columns with different polarities combined with two detectors.</li><li>Avoiding internal standards such as n-propanol, n-butanol, and other substances that are formed <span>postmortem</span> in forensic investigations.</li><li>Utilizing tert-butanol as an internal standard in forensic toxicological practice.</li><li>Analysis of quality-control (QC) concentrations defined by law for DUI threshold limits, with verification that precision and accuracy remain within acceptable ranges.</li><li>Ensuring that sample preparation is performed in facilities free from exposure to airborne organic solvent vapors, particularly methanol and ACN (which are routinely used for protein precipitation in other toxicological analyses).</li><li>Preparation of analytical batches including two replicates of each sample, analyzed in a forward- and reverse-order sequence (e.g., samples 1–5 followed by 5–1) to verify analytical consistency.</li><li>Verification of internal standards and blank samples in each batch to ensure the absence of contamination during the pre-analytical phase.</li><li>Ensuring compliance with the acceptance criterion of a maximum 5% deviation between results, based on four measurements per sample.</li><li>Careful chromatographic evaluation and critical assessment of peak shape, symmetry, and resolution to minimize the risk of undetected interferences, particularly when using detectors such as FID, where retention time is the sole discriminating parameter.</li><li>Routine performance of independent proficiency tests to assess whether the method meets required accuracy and precision standards.</li><li>Biological fluids intended for forensic toxicology testing should be collected in tubes containing sodium fluoride (NaF) and stored under controlled conditions in a refrigerator maintained at 2–8 °C.</li></ul></div></div>

Dual-Column HS-GC-FID/FID Method for In-Depth Analysis of Low-Molecular-Weight Volatile Alcohols in Postmortem Biological Material

<p><strong>In the week of June 29, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Metrohm: Simplifying Through-Container Testing with Raman Spectroscopy in the Pharmaceutical Industry</strong></h5><ul><li>Mo, 29.6.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6308">Registration</a></li></ul><p>In this webinar, we will demonstrate a more robust and practical alternative to SORS for see-through Raman analysis.</p><h5><strong>2. SelectScience: End-to-end PAT: Connecting advanced analytics and data across the bioprocess lifecycle</strong></h5><ul><li>Mo, 29.6.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6307">Registration</a></li></ul><p>Learn how integrated PAT strategies combining NMR, Raman, IR, and digital workflows enable continuous process understanding, smoother tech transfer, and QbD from development to GMP manufacturing.</p>

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INFICON

<p><strong>Agilent is delighted to welcome you to the #SuperSmartGC Virtual Meeting.</strong></p>
<p>This is a virtual event to share the latest in Agilent&#39;s smart, connected Gas Chromatography instruments.</p>
<p>We will introduce the new <strong>8697 headspace sampler</strong> with, intelligent self-awareness; Agilent&#39;s first headspace sampler with integrated GC communication. Prevent downtime and troubleshoot problems with the knowledge you can migrate your legacy methods with confidence.</p>
<p>The meeting is a mix of live presentations and on-demand content you can join and view, wherever you are and whenever you can.</p>
<p><strong>Live broadcast presentation with Q&amp;A from 1:30 PM CEST</strong></p>
<h5><strong>1. Experiences and Learnings from Implementation of Intuvo 9000 GC/MS in forensic drug testing</strong></h5>
<blockquote>
<p><strong>Presenter: Ailidh Wilson</strong> (Forensic Examiners, Scottish Police Authority Forensic Services)<br/><strong>Presenter: Christina Johnson</strong> (Forensic Examiners, Scottish Police Authority Forensic Services)</p>
</blockquote>
<h5><strong>2. Blood Alcohol Analysis in Forensic Testing</strong></h5>
<blockquote>
<p><strong>Presenter: Abbey Fausett</strong> (Application Specialist, Agilent Technologies, USA)</p>
</blockquote>
<h5><strong>3. Climbing the peaks of GC Intelligence. Life with your Smart GC from Agilent</strong></h5>
<blockquote>
<p><strong>Presenter: George Reiner</strong> (GC Software Product Manager)<br/><strong>Presenter: James McCurry</strong> (Senior Applications Chemist, Agilent Technologies Inc, USA)</p>
</blockquote>
<p>As always this is your meeting - feel free to chat with other users and our team of experts, give us your feedback and requests for development. </p>
<p>Register today and stay up-to-date with the latest technological developments.</p>


Agilent Technologies: Agilent SuperSmartGC Virtual Meeting 19 May

Agilent SuperSmartGC Virtual Meeting 19 May

<ul>
<li><p>Do you do gas analysis and want to optimize them?</p>
</li>
<li><p>Do you want to perform gas analysis in the future?</p>
</li>
<li><p>Do you follow the newest trends and want to be updated?</p>
</li>
</ul>
<p>We would like to show you how to optimize and simplify your measurement routine to reduce errors, save time and increase the sample throughput.</p>
<h3><strong>We will be covering the following topics:</strong></h3>
<ul>
<li>Online measurement</li>
<li>Automation using Valco Valve</li>
<li>Handling large amounts of data</li>
<li>Reduce errors, save time and increase the sample throughput.</li>
</ul>


INFICON: Easy Analysis of Multiple Gas Samples 

Easy Analysis of Multiple Gas Samples 

<p><strong>Fast GC means different things to different people.  You may not have the latest and greatest GC system out there, but that doesn’t mean that you can’t shorten up your analysis and increase your throughput.</strong></p>
<p>We will also discuss capabilities within your system that you may have not known about, and how to exploit them.  Speed does not come without sacrifice.  We will also talk about the ‘potential’ negatives of speeding up your analysis. </p>
<blockquote>
<p><strong>Presenter: Simon Jones (GC Applications Engineer/Scientist, Agilent Technologies, Inc.)</strong></p>
</blockquote>
<blockquote>
<p>Simon Jones has over 23 years of GC experience. For the last 15 years, he has been with Agilent as a GC applications engineer/scientist based out of the GC column manufacturing facility if Folsom California. In his roles he has assisted with application development, troubleshooting chromatographic issues, and assisting with instrument configurations. Prior to joining Agilent in 2005, he worked in an analytical lab for the power industry, developing and optimizing testing methodologies for insulating fluids and materials in transformers.</p>
</blockquote>


Agilent Technologies: What Does Fast GC Really Mean? How To Speed Up your Analysis With Out Changing The Hardware

What Does Fast GC Really Mean? How To Speed Up your Analysis With Out Changing The Hardware

<blockquote>
<p><strong>Presenter: Chris Goss (InnoTech Alberta, Research Technologist)</strong></p>
</blockquote>
<blockquote>
<p>Chris has worked in gas chromatography for 20+ years after graduating from the University of Alberta. The last 20 years doing research, method development, and standard methods for the petroleum testing industry</p>
</blockquote>
<blockquote>
<p><strong>Presenter: Lee Marotta (Principal Field Application Scientist, PerkinElmer)</strong></p>
</blockquote>


PerkinElmer University Online Learning: Gas Chromatography Spring 2021 Semester

Advanced Applications Using Micro-fluidic Switching (Dean Switch, Splitting and Backflushing)

<blockquote>
<p><strong>Presenter:  Alex Maitan (Field Application Specialist, PerkinElmer)</strong></p>
</blockquote>
<blockquote>
<p><strong>Presenter: Tom Kwoka (Product Specialist, PerkinElmer)</strong></p>
</blockquote>
<blockquote>
<p><strong>Presenter: Leeman Bennington (Sr. Field Application Scientist, PerkinElmer)</strong></p>
</blockquote>


Testing for Residual Solvents and Terpenes in Cannabis

<p><strong>With these fundamentals you will learn all the ins and outs on the LC-GC coupling, GC×GC and Time-of-Flight MS to able to determine MOSH and MOAH in food products.</strong></p>
<h3><strong>Day one on 28th April, 02.00 pm (CEST) features:</strong></h3>
<h4><strong>1. &quot;Fundamentals on LC-GC Coupling&quot;</strong></h4>
<p>The  analysis  of  MOSH/MOAH  is  very  highly  complex  and  has  several  challenges. MOSH/MOAH is not a single analyte, it is a complex mixture of different compounds. The composition of this mixture is always different. Another challenge  is,  that  natural  compounds  in  the  samples  are  coeluting  with  the  mineral oil compounds and have to be removed before getting a good result. The lecture covers following topics:</p>
<ul>
<li>Background of MOSH/MOAH and contamination sources</li>
<li>Analysis of MOSH/MOAH using LC-GC-FID</li>
<li>Technology of the LC-GC coupling</li>
<li>Sample clean up using automated epoxidation</li>
<li>Sample cleanup using automated AlOx cleanup</li>
<li>Strategies for the data analysis for LC-GC-FID data</li>
<li>Coupling of LC-GC-FID system with other techniques</li>
<li>Summary</li>
</ul>
<blockquote>
<p>Presenter: Dr. Andreas Bruchmann (Axel Semrau GmbH &amp; Co KG, Managing Director, Sprockhövel, Germany)</p>
</blockquote>
<blockquote>
<p>After studying Analytical Chemistry at the University of Bochum, Andreas Bruchmann joined Axel Semrau in 1992. He worked in different departments before becoming Managing Director in 2010. Now he is responsible for the business unit Chromatography, which supplies worldwide automated application solutions for the food and pharmaceutical industry. He was  involved in the development of the CHRONECT MOSH/MOAH Workstation from the beginning in 2010.</p>
</blockquote>
<h4><strong>2. &quot;Principles and Instrumentation of GC×GC and ToF-MS&quot;</strong></h4>
<p>Comprehensive  two-dimensional  gas  chromatography,  or  GC×GC,  is  a  relatively new form of chromatography in  which  every  peak  eluting  from  the  first column is subjected to a very fast separation  on  a  second  column  with  a  different  stationary  phase.  In  this  way two dimensional separations are obtained  where  peaks  that  coeluted  on  the  first  column  are  separated  on  the second. This gives the technique a unique  separation  power.  Additional  advantages    include    an    improved    sensitivity and group-type selectivity. It is this latter feature that makes GC×GC ideal for MOSH/MOAH separations. The saturated species can be separated from the unsaturated or aromatic ones.</p>
<p>Because   the   peaks   generated   in   GC×GC  are  extremely  narrow,  very  fast   detectors   are   needed.   Peak   widths can be as low as 0.2 seconds at  base-line,  requiring  detectors  that  have  scan  rates  of  100  Hz  or  more.  This is not a problem for the flame-ion-ization  detector  (FID),  but  it  requires  the  use  of  fast  scanning  time-of-flight  (ToF)  mass  spectrometers.  With  such  devices scan rates as high as 500 Hz can  be  obtained.  In  ToF-MS  devices  short pulses of ions are shot into a flight tube and the time it takes for the ions to reach the end of the tube is measured. Lighter  ions  travel  fast  and  have  a  relatively  short  flight  time  whereas  the  heavier  ions  require  longer  to  traverse  the  tube.  The  principles  and  optimization of ToF MS analysers and their  combination  with  GC×GC  will  be discussed with special attention for the compromise between scan speed, sensitivity and mass resolution.</p>
<blockquote>
<p>Presenter: Prof. Dr. Ir. Hans-Gerd Janssen (University of Wageningen, Laboratory for Organic Chemistry and Unilever R&amp;D, Wageningen, the Netherlands)</p>
</blockquote>
<p>This Workshop is free of charge and will continue on Day 29th April, 02:00 pm (CEST) with the presentation by Prof. Giorgia Purcaro</p>
<p><strong>&quot;LC-GC×GC–ToF-MS/FID: A Powerful Platform for MOSH&amp;MOAH Determination&quot;.</strong></p>
<p>Please register also for the second day of the MOSH/MOAH Workshop!</p>


Pixabay/Vane Monte: LECO MOSH/MOAH Workshop - Fundamentals On Comprehensive MOSH/MOAH Analysis

LECO MOSH/MOAH Workshop - Fundamentals On Comprehensive MOSH/MOAH Analysis – Day 1

<p><strong>With these fundamentals you will learn all the ins and outs on the LC-GC coupling, GC×GC and Time-of-Flight MS to able to determine MOSH and MOAH in food products.</strong></p>
<p>The second part on Day 29th April, 02:00 pm (CEST) features the presentation:</p>
<h4><strong>&quot;LC-GC×GC–ToF-MS/FID: A Powerful Platform for MOSH&amp;MOAH Determination&quot;</strong></h4>
<p>Mineral oil hydrocarbons (MOHs) are a  very  complex  mixture  of  isomers  mainly associated with two classes of compounds, namely MOSH (composed of    linear,    branched,    and    alkyl-substituted cyclo-alkanes) and MOAH (which  includes  primarily  alkyl-substi-tuted  (poly)aromatic  hydrocarbons  at  a different number of fused rings). The analysis of such a contaminant in food is a challenging task, mainly due to the high complexity of the matrices and the high affinity with the lipid fraction and many of its components. Moreover, FID detection needs to be employed since it gives a virtually equal response per unit of mass for all hydrocarbons, avoiding the  calibration  problems  encountered  with mass spectrometry (MS) (reference standards not available). Nevertheless, the lack of a confirmatory method and the  capability  to  discriminate  natural  interferences  from  real  contamination  remains still an actual problem. In this context,   the   hyphenated   LC-GC-FID   method,  longly  proposed  as  the  most  suitable solution for this determination, fails to provide a solution. On the other side, GC×GC has been proposed for confirmatory  purposes  and  improved  the separation of interferents. Moreover, the  improved  separation  in  the  2D  space  also  allows  a  more  detailed  characterization of the contamination, providing  information  relevant  to  the  toxicological   evaluation.   However,   GC×GC failed to provide quantitative data in the specific MOSH and MOAH case. </p>
<p>A powerful LC-GC×GC-ToFMS/FID  platform  has  been  proposed  to  merge the two separation techniques’ assets,   achieving   an   extraordinary   performance level for both qualitative and quantitative purposes. Moreover, a novel quantification strategy has been proposed to overpass the limitation of the usual two-dimensional software to deal  with  the  specific  requirement  of  MOSH and MOAH quantification (i.e., mainly  the  subtraction  of  the  riding  peaks).  Therefore,  such  a  platform  seems  the  most  suitable  candidate to  meet  the  EFSA  and  the  European  Union’s   current   requirements   for   a   full   characterization   of   the   MOH   contamination in food. </p>
<blockquote>
<p>Presenter: Prof. Giorgia Purcaro (University of Liège, Gembloux Agro-Bio Tech, MS Food Science and Technology; PhD in Food Science, Liège, Belgien)</p>
</blockquote>
<p>This Workshop is free of charge. </p>


LECO MOSH/MOAH Workshop - Fundamentals On Comprehensive MOSH/MOAH Analysis

LECO MOSH/MOAH Workshop - Fundamentals On Comprehensive MOSH/MOAH Analysis – Day 2

<p><strong>Wasson-ECE Instrumentation has been designing, building, and applicating turn-key gas chromatographs for over 35 years. Beverage-Grade Carbon Dioxide Analyzers are a specialty, and our beverage industry customers appreciate the versatility and sensitivity of our instruments. Both lab and on-line versions are available and address gas or liquid phase CO2.</strong></p>
<h3><strong>Learn how our analyzers deliver:</strong></h3>
<ul>
<li><p>Speciated sulfurs, oxygenates, permanent gases, toxics, refrigerants, hydrocarbons, and more – in a single analyzer. Why speciated? Because knowing that you have “sulfur” is less diagnostically useful than knowing exactly which one! </p>
</li>
<li><p>Completely customizable analyte list.</p>
</li>
<li><p>Generate dynamic COAs, meet product specs, and increase profitability.</p>
</li>
<li><p>100%  We guarantee our analyzers AND we guarantee their results.</p>
</li>
</ul>
<h3><strong>This configuration allows for:</strong></h3>
<ul>
<li><p>ppb-level detection of the analytes you really need to see</p>
</li>
<li><p>unambiguous quantitation of co-eluting compounds</p>
</li>
<li><p>identification of the compound causing that mystery peak in your chromatogram</p>
</li>
<li><p>removal of the guesswork in your chromatography!</p>
</li>
</ul>
<p>We&#39;ve mastered lab and process beverage-grade CO2 analysis - and we&#39;ll show you the data to prove it!</p>


Pixabay/Rudy and Peter Skitterians: Monitoring ppb Impurities in Beverage-Grade Carbon Dioxide

Monitoring ppb Impurities in Beverage-Grade Carbon Dioxide

We love combined GC-MS/FID/TCD for beverage-grade CO2 analysis! Why? Meet specs without guessing what's in your carbon dioxide!

<h3><strong>Navigate where you want to go from the main exhibition hall:</strong></h3>
<ul>
<li>Technology Booths</li>
<li>Auditorium: New Technologies</li>
<li>Software Center: Smart Alerts, OpenLab CDS, I-Lab, Compliance Services</li>
<li>Resource Center: Company and Career Information</li>
<li>Demonstration Center</li>
<li>Meetings focusing on BioPharma &amp; Pharma and Food &amp; Environmental Solutions</li>
<li>Networking Lounge</li>
</ul>
<h3><strong>Live broadcast presentations with speakers Q&amp;A</strong></h3>
<h5><strong>Innovation at Agilent - accelerating next generation science</strong></h5>
<p>Speaker: Darlene J.S. Solomon, Ph.D. (Chief Technology Officer and Senior Vice President, Agilent Technologies, USA)</p>
<h5><strong>Vitamin and Amino Acid analysis for nutritional labelling</strong></h5>
<p>Speaker: Ansuman Mahato (LC Application Specialist, Agilent Technologies, India)</p>
<h5><strong>OpenLab - Benefits of Virtualization and Cloud Environments</strong></h5>
<p>Speaker: William Goodman (Director of Product Management for Software &amp; Informatics, Agilent Technologies, USA)</p>
<h5><strong>Enabling science. Simplifying services with CrossLab Lab-Wide Services</strong></h5>
<p>Speakers: Brian Duffy (Service Business Consultant, Agilent Technologies, USA)</p>
<p>Speakers: Brittany Stille (Product Manager of Lab-Wide Instrument Services, Agilent Technologies, USA)</p>
<h5><strong>Assessment of Residual Solvents in pharmaceuticals to updated ICH Q3C R8/USP 467</strong></h5>
<p>Speaker: Ian Eisele (Application Scientist, Agilent Technologies, USA)</p>
<h5><strong>OpenLab - An Integrated Informatics systems for greater efficiency and data integrity</strong></h5>
<p>Speaker: Thomas Schmidt (Marketing Director for Software &amp; Informatics, Agilent Technologies, Germany)</p>


Agilent Technologies: Agilent Science and Technology Virtual Symposium 

2021 Agilent Science and Technology Virtual Symposium

Advancing Science Together. Innovation in life science and applied chemicals with you in mind. ASTvS 2021 is live across several continents.

<p><strong>Sharing the latest in Agilent&#39;s latest technology developments and capabilities, new applications and some customer stories.</strong></p>
<p>Topics include safety, taste profiling, quality and general safety of raw materials and final products. </p>
<p>The meeting is a mix of live presentations and on-demand content you can join and view, wherever you are and whenever you can.</p>
<h5><strong>14:00 CEST Botanicals by headspace-SPME arrow-GCxGC-MSD/FID</strong></h5>
<p><em>Speaker: Andrew Ward (JSB, UK)</em></p>
<p><strong>Abstract:</strong> Gins are a neutral spirit flavoured with various botanicals. Hundreds of botanicals are used to flavour gin, most commonly juniper with other seeds, herbs, roots and fruits.  The large numbers of compounds contributing to the aroma and flavour of gins coupled with the fact that flavour- and fragrance-key components can be present at very low concentrations makes chemical profiling challenging.</p>
<p>GCxGC-MS is the ideal analytical technique to accommodate the complexity of the samples due to its enhanced peak capacity and sensitivity. Sample preparation and sample introduction introduce further challenges due to the complex nature of the samples. Headspace-SPME Arrow is a fully automated sample preparation technique with the ability to extract targeted key compounds present a low concentrations whilst avoiding matrix compounds present at high concentrations. The combination of HSSPME Arrow with GCxGC-MSD/FID is a very powerful tool in the comparative analysis of samples with complex matrices.</p>
<h5><strong>15:00 CEST Scotch Whisky profiling by accurate mass GCMS and differential analysis using Mass Profiler</strong></h5>
<p><em>Speaker: Praveen Kutty (Application Chemist, Agilent Technologies, UK)</em></p>
<p><strong>Abstract:</strong> Scotch whisky has been distilled since at least the 15th century from malted barley and water.  Two type of whisky are commonly found; blended and single malt, from a single distillery.</p>
<p>Single Malt Scotch can be classified by its region such as Highland, Speyside, Island, Lowland and the taste is influenced by the water, the grain, the fuel source to toast the grain and the barrel the spirit is aged in.  The presentation will demonstrate an untargeted analysis of variety of  whisky samples using Agilent 7250 GC/Q-TOF and differential analysis workflow using MPP to identify unique features of different whisky classes to determine if a blind sample can be identified by this approach.</p>


GCMS webinars focusing on GC - page 31