In this technical tip from Phenomenex, the topic of gas chromatography (GC) column trimming is addressed from a troubleshooting perspective. The key question explored is whether trimming a GC column is necessary and how it impacts chromatographic performance.<h3>Why Trim a GC Column?</h3>Column trimming is primarily used to restore chromatographic performance by removing damaged or contaminated sections, typically located at the column inlet.<h5>1. Baseline Bleed, Noise, Ghost Peaks, Poor Peak Shape</h5><ul><li>Cause: Column contamination</li><li>Removing the contaminated stationary phase at the column entrance helps restore performance.</li></ul><h5>2. Elevated Baseline (Especially at High Temperature)</h5><ul><li>Cause: Column bleed</li><li>Degradation of the stationary phase due to oxygen exposure or thermal damage leads to increased baseline.</li></ul><h5>3. Ghost Peaks (Peaks Without Injection)</h5><ul><li>Cause: Residual sample or contamination</li><li>Compounds trapped at the beginning of the column can appear as peaks even when no sample is injected.</li></ul><h5>4. Peak Tailing (Asymmetrical Peaks)</h5><ul><li>Cause: Damaged or contaminated column sections</li><li>These issues result in adsorption effects or poor flow dynamics.</li></ul><h5>5. Retention Time Shifts</h5><ul><li>Cause: Contamination or damage near the inlet</li><li>Although trimming slightly changes retention time, it can correct shifts caused by inlet-side issues.</li></ul><h5>6. Baseline Noise and Spikes</h5><ul><li>Cause: Particulate matter or degraded stationary phase</li><li>These can lead to detector instability and random signal fluctuations.</li></ul><h5>7. Baseline Drift or Wander</h5><ul><li>Cause: Contamination or oxidized column sections</li><li>Removing these regions stabilizes the baseline.</li></ul><h5>8. Loss of Resolution or Sensitivity</h5><ul><li>Cause: General column degradation</li><li>Trimming removes the most exposed and damaged portions, effectively rejuvenating column performance.</li></ul><h3>How to Trim a GC Column</h3>A capillary GC column consists of:<ul><li>Polyimide outer coating (protective layer)</li><li>Fused silica tubing (fragile but flexible core)</li></ul><h3>Step-by-Step Procedure</h3><h5>1. Scoring the Column</h5><ul><li>Use a ceramic wafer</li><li>Hold it at an inclined angle</li><li>Score the polyimide coating perpendicular to the column</li></ul><h5>2. Breaking the Column</h5><ul><li>Perform a quick, decisive flick</li><li>This ensures a clean, square cut</li></ul><h5>3. Inspecting the Cut</h5>After trimming, visually inspect the column end.<h3>Examples of Column Cuts</h3><h4>Good Cut</h4><ul><li>Clean, square end</li><li>Ensures proper sealing and connection</li></ul><h5>Bad Cuts</h5><ul><li>Slight Irregularity<ul><li>Small imperfection at the edge</li><li>Can cause leaks and active sites</li></ul></li><li>Poor / Rough Cuts<ul><li>Uneven or jagged edges</li><li>Lead to:<ul><li>Poor connections</li><li>Active sites</li><li>Peak tailing</li></ul></li></ul></li></ul><h2>Conclusion</h2>Trimming a GC column is a simple yet effective troubleshooting step. By removing contaminated or damaged sections—especially near the inlet—it can resolve a wide range of chromatographic issues, including baseline instability, ghost peaks, and loss of performance.Proper cutting technique is essential to avoid introducing new problems such as leaks or active sites.

Trimming a GC Column: Purpose, Symptoms, and Proper Technique

<h3>We're excited to announce that <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity Chromatography Software</a> version 10.1.2 is now available!</h3>This minor update expands Clarity’s portfolio with new control modules.<h4>Newly added Instrument control modules</h4><ul><li>Ecom auxiliary modules</li><li>HTA ICF control modules</li><li>Spark pump</li></ul><h4>Updated Instrument control modules</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/168">Ecom</a> HPLC</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/328">Knauer</a> HPLC</li><li>Spark ICF control modules</li><li>YoungIn Chromass HPLC</li></ul><blockquote>For a complete list of module changes, see the <a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1">Changelog</a>. For more info about exciting new features directly in Clarity, explore what was introduced in the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5622">Clarity 10.1 release highlights</a>.Clarity can control 1000+ instruments; the <a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/controls">list can be previewed here</a>.</blockquote><h4>Supported Instruments in Clarity (DataApex) — Quick Guide</h4>Clarity Chromatography Software supports a wide range of chromatographs and peripherals via digital control (DD) and analog acquisition (A/D) using the Colibrick module.<h5>Gas Chromatographs (GC)</h5>Digital integration over LAN/RS232 (many via ICF):<ul><li>Agilent: 5890, 6890, 7890, 8860, 8890, Intuvo 9000</li><li>Shimadzu: GC-2010/2014, Nexis GC-2030</li><li>Thermo Fisher: TRACE 1300/1310</li><li>PerkinElmer: Clarus 400–690</li><li>Also supported: Dani, Ellutia, Young In Chromass, Apix, Fuli, GOW-MAC (selected models)</li></ul><blockquote>Note: Most Agilent 6890–8890 and Intuvo use LAN – ICF.</blockquote><h5>HPLC Systems</h5>Full system/module control:<ul><li>Agilent 1100–1290 Infinity II (ICF)</li><li>Shimadzu LC-10/20 and Nexera LC-40</li><li>PerkinElmer Flexar / NexSAR</li><li>Knauer Azura / BlueShadow / Smartline</li><li>Hitachi Chromaster / Primaide</li><li>Young In Chromass ChroZen series</li><li>Sykam S500–S600, Watrex Streamline, Hanon LC7000–7300</li></ul><h5>HPLC Modules (Pumps, Detectors, Ovens, Fraction Collectors)</h5><ul><li>Pumps: Agilent 1100–1290 families, Knauer, Shimadzu, PerkinElmer, Sykam, SSI, Ecom</li><li>Detectors: VWD/DAD(PDA)/RID/FLD/ELSD across Agilent, Shimadzu, Knauer, PerkinElmer, Young In Chromass, Ecom, etc.</li><li>Column Ovens: Agilent G1316x / G7116x, Shimadzu CTO-20/30/40, Knauer CT2.1, PerkinElmer Flexar</li><li>Fraction Collectors: Knauer FC 6.1, Teledyne FOXY series, Ecom ECF 2096, Waters Fraction Collector II</li></ul><h5>Autosamplers</h5><ul><li>Agilent GC ALS (7673/7683/7693/8697), HPLC ALS modules (G1313A–G7167C)</li><li>Shimadzu AOC-20 / AOC-5000+, SIL-10 / SIL-20 / SIL-40 series</li><li>CTC Analytics PAL, HTA autosamplers, Spark Alias/UHPLC, Knauer AS 6.1L</li><li>PerkinElmer Flexar / NexSAR AS</li></ul><h5>Other Devices</h5><ul><li>GC×GC modulators (e.g., Charles University GC×GC Modulator)</li><li>Valves &amp; switch modules (Agilent, Knauer, Shimadzu, VICI-Valco)</li><li>Degassers, flow monitors, managers, interfaces</li><li>LC-MS / GC-MS: Advion Expression CMS, Microsaic 4500 MiD, Markes BenchTOF (and others)</li><li>Balances (EA extension): Mettler Toledo, Sartorius</li></ul><h5>Analog Acquisition (Colibrick)</h5>A/D support for legacy or analog-output devices:<ul><li>GC: Agilent 5880/4890A, Varian 3xxx/3800/3900, PerkinElmer Clarus series, Thermo TRACE, Shimadzu GC-14/9A, Scion 43x/45x/83xx/85xx, etc.</li><li>HPLC Detectors: Waters 2487/2489, ESA Corona, Hitachi L-series, JASCO FP/UV, Ecom LCD series, many others</li><li>Elemental &amp; Amino Acid Analyzers: Carlo Erba/Costech ECS, Biochrom 20/30+</li></ul>If you are interested in a DEMO VERSION, contact us!

DataApex Clarity Chromatography software 10.1.2 just released!

🎤Jessica WhitehouseHaloacetic acids (HAAs) are disinfection byproducts formed when chlorine or bromine reacts with organic matter in water—and some are linked to serious health concerns. In this episode of Concentrating on Chromatography, we sit down with Jessica Whitehouse, MSc student at the University of Calgary, to discuss how she developed a GC-MS method to detect and quantify HAAs in real-world water samples.During her undergraduate research at Thompson Rivers University, Jessica tackled a major challenge faced by many academic labs: how to analyze regulated environmental contaminants without access to GC-ECD instrumentation. &nbsp;Using dispersive liquid–liquid microextraction, derivatization, and GC-MS, she built a faster, more accessible workflow—and applied it to tap water, swimming pools, and hot tubs.<h4>In this conversation, we cover:</h4><ul><li>What haloacetic acids are and why they matter</li><li>Why standard EPA methods can be difficult for smaller or teaching-focused labs</li><li>How GC-MS can be adapted for HAA analysis</li><li>The challenges of derivatization and temperature program optimization</li><li>Unexpected findings in brominated vs. chlorinated HAAs</li><li>Why pool and hot tub water can show surprisingly high HAA levels</li><li>The excitement (and frustration) of first-time method development</li><li>Advice for undergraduate and early-career analytical chemists</li></ul>Jessica also shares how this project led directly to her current MSc research on ozone and nanobubble water disinfection, where she’s now expanding into ion chromatography.Whether you work in environmental analysis, chromatography, GC-MS, or are just starting your journey in analytical chemistry, this episode offers practical insight into real lab constraints, method development, and the joy of finding your first analyte peak.<h3>Video Transcription</h3><h4>Introduction</h4>Haloacetic acids (HAAs) are an important class of disinfectant byproducts formed when organic matter present in water reacts with chemical sanitizers. Because several HAAs are associated with adverse health effects, their determination remains relevant in environmental and public health analysis. This interview highlights the academic pathway and research experience of Jessica, whose undergraduate work focused on the development of a gas chromatography–mass spectrometry (GC-MS) method for the analysis of HAAs in pool and hot tub water.Her project emerged from a combination of academic interest in analytical chemistry, practical experience with water testing, and the constraints of instrument availability in an undergraduate research setting. The resulting workflow illustrates how method adaptation, critical problem-solving, and persistence can enable meaningful analytical research even when standardized methods are not directly accessible.<h4>Academic Background and Entry into Analytical Chemistry</h4>Jessica completed a Bachelor of Science in Chemistry with a minor in Physics at Thompson Rivers University in British Columbia. Her interest in analytical chemistry developed during her second year of study, when coursework revealed the quantitative and detail-oriented nature of the discipline. This emphasis on numerical interpretation, precision, and method development aligned strongly with her academic strengths and motivated her to pursue analytical research.Her specific interest in water chemistry originated even earlier through practical work in a pool and hot tub store, where she became familiar with routine water testing and the chemical factors influencing water quality. This early exposure led naturally into undergraduate research under the supervision of Dr. Sharon Brewer, whose expertise in water analysis provided an ideal foundation for the project.<h4>Haloacetic Acids as Disinfectant Byproducts</h4>Haloacetic acids are a subset of disinfectant byproducts generated when sanitizing agents react with natural organic matter in water. In treated recreational water systems such as pools and hot tubs, disinfectants are essential for microbial control, yet they can also lead to formation of unwanted chemical byproducts. Because some HAAs are considered potentially harmful, their occurrence and concentration warrant analytical attention.In this study, both chlorinated and brominated HAAs were of interest. Although the tested water systems were primarily sanitized using chlorine-based products, the occurrence of brominated HAAs emerged as a notable and somewhat unexpected finding.<h4>Analytical Challenges and Method Selection</h4>A major challenge in the project was the lack of access to the instrumentation required for the standard EPA-based method initially considered for HAA analysis. The available protocol depended on GC-ECD instrumentation, which was not accessible at the university. This limitation required the development of an alternative strategy based on the instruments available locally.GC-MS was selected as the most practical analytical platform. To support this approach, Jessica identified a literature source describing a similar method that could be adapted to her research aims. In parallel, dispersive liquid–liquid microextraction was introduced into the workflow as a means of sample preparation, providing valuable methodological experience beyond the standard undergraduate laboratory curriculum.This adaptation illustrates a common reality in academic research: analytical methodology is often shaped not only by ideal regulatory procedures, but also by local instrument access, scheduling limitations, and the practical needs of the researcher.<h4>Need for Derivatization in GC-MS Analysis</h4>A central analytical issue was that HAAs are inherently nonvolatile, which makes them poorly suited to direct GC analysis. To enable gas chromatographic separation, derivatization was required to convert the analytes into more volatile derivatives with more favorable boiling characteristics.In this method, derivatization with octanol was employed. This modification improved volatility and also generated larger fragments, which aided mass spectral interpretation by making the analyte fragmentation patterns easier to distinguish. Thus, derivatization served both chromatographic and mass spectrometric purposes.<h4>Optimization of the GC Temperature Program</h4>Considerable effort was devoted to optimization of the GC temperature program. The main difficulty did not arise solely from the analytes themselves, but from the derivatization reagent. Octanol produced a broad and persistent chromatographic feature, including a significant shoulder extending into later retention times. This complicated separation and increased pressure to keep the method sufficiently short for routine sample throughput.Among the analytes, monochloroacetic acid proved especially problematic. Because it differed only subtly in structure and produced overlapping behavior relative to the octanol-derived background, its signal was difficult to isolate confidently. Although chlorine-containing fragments could be observed, precise assignment remained challenging. This difficulty underscores how small structural differences and matrix-related interferences can complicate quantitative GC-MS workflows.<h4>Method Performance and Practical Advantages</h4>Although the adapted GC-MS method was developed out of necessity, it also provided practical advantages over the more standardized workflow that had initially been considered. In particular, the derivatization step in the adapted approach required only approximately 10 minutes, whereas the more conventional procedure involved a water bath step lasting around two hours. In addition, the adapted workflow offered shorter overall preparation and analysis timing, allowing batches of samples to be prepared and placed on the autosampler within a normal working schedule.From a practical research perspective, this translated into substantially improved laboratory efficiency. The ability to complete derivatization quickly and begin automated sample analysis without extensive delays made the workflow more manageable and better suited to the demands of an undergraduate project.<h4>Unexpected Findings: Brominated HAAs in Chlorine-Sanitized Systems</h4>One of the more surprising outcomes of the study was the predominance of brominated HAAs, despite the fact that the investigated pools and hot tubs were sanitized using chlorine-based treatments. Four of the systems relied on sodium chloride electrolysis to generate chlorine species, while others used chlorine-containing puck formulations commonly applied in recreational water treatment.Given these conditions, higher levels of chlorinated HAAs might have been expected. Instead, the results suggested a greater abundance of brominated HAAs. A plausible explanation is the presence of bromine-containing impurities in commercial pool and hot tub chemicals. Although such impurities may occur at relatively low levels, they can still influence disinfectant byproduct formation. The observation highlights the importance of considering the full chemical composition of treatment products, not merely their primary declared active ingredients.<h4>Value of Practical Industry Experience</h4>Jessica’s prior work in the pool and hot tub industry provided an unusually strong contextual advantage for the project. Because the samples originated from store clients, she had access to detailed information about the chemicals used in each system, including safety data sheets and knowledge of treatment timing. This background significantly strengthened interpretation of the analytical results by linking measured byproducts to known product usage patterns.Such integration of practical field knowledge with laboratory analysis represents an important strength in applied environmental chemistry, particularly when studying real-world water systems rather than idealized laboratory samples.<h4>Scientific Development and Early Research Motivation</h4>An especially valuable element of the project was the role it played in building research confidence. Jessica described the first successful identification of an analyte peak as a memorable turning point, reflecting the emotional significance of early experimental success in scientific training. In analytical chemistry, where method optimization often involves repeated setbacks and ambiguous data, such moments can be critical in sustaining motivation and reinforcing scientific identity.This experience also informed her advice to early-stage researchers: unfavorable or unexpected outcomes still constitute valid results. Negative or imperfect findings remain analytically meaningful and contribute to scientific understanding, provided they are interpreted carefully.<h4>Connection to Current Research</h4>Jessica is now working at the University of Calgary on a different project focused on ozone and nanobubble disinfection. Although the analytical platform and immediate research questions have changed, the conceptual connection to her earlier work remains clear. Her experience with disinfectant byproducts and water chemistry directly supported her transition into this new role and helped position her as a strong candidate for research in water treatment-related systems.She also expressed interest in expanding her analytical expertise through ion chromatography, which will play a role in her current work. This transition reflects the broader development of an environmental analytical chemist whose work continues to center on water quality, disinfection chemistry, and the analytical tools needed to investigate both.<h4>Public Health Relevance</h4>A notable practical implication of the project concerns recreational water safety. Jessica emphasized that pool and hot tub water should not be ingested, a recommendation already widely understood in general terms but further reinforced by her findings. In at least one case, HAA concentrations were reported at levels far above the federal drinking water regulation threshold. While such regulations are designed for potable water rather than recreational water, the comparison nevertheless illustrates the extent to which disinfectant byproducts may accumulate in these environments.She also noted that several HAAs are classified as probable human carcinogens, with prolonged exposure linked to serious health concerns. Although occasional accidental ingestion is not equivalent to chronic exposure, the findings reinforce the importance of appropriate hygiene, safe water maintenance practices, and awareness of chemical byproduct formation in recreational systems.<h4>Conclusion</h4>This research demonstrates how meaningful analytical chemistry can emerge from a combination of scientific curiosity, practical constraints, and strong mentorship. By adapting a GC-MS workflow for the determination of haloacetic acids in pool and hot tub water, Jessica developed a method that was both workable within local instrument limitations and efficient enough to offer practical benefits over more conventional procedures.Beyond the analytical results themselves, the project highlights several broader themes: the value of undergraduate research, the importance of flexibility in method development, the benefit of practical contextual knowledge, and the relevance of environmental analytical chemistry to real-world public health questions. It also shows how early research experiences can shape a long-term scientific trajectory, leading from undergraduate investigation to continued work in water chemistry and disinfection science.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

Detecting Haloacetic Acids in Water with GC-MS

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Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

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Thermo Scientific Trace™ TR-V1 GC Columns

Thermo Scientific™ TRACE TR-V1 GC Columns are mid-polarity, thick film columns.

Thermo Scientific™ TRACE TR-V1 GC Columns are mid-polarity, thick film columns.<ul><li>Mid-polarity phase, 6% Cyanopropylphenyl Polysiloxane</li><li>Thick films for the analysis of volatile analytes</li><li>Low-bleed suitable for MS detection</li></ul><h4>Recommended For:</h4><ul><li>Volatile Organics</li><li>Alcohols</li><li>EPA 502.2, 608 and 624</li></ul><h4>Similar To:</h4><ul><li>DB-624</li><li>BPX Volatiles</li><li>Rtx Volatiles</li><li>VOCOL 56</li><li>OV-624</li><li>AT-624</li><li>HP-VOC</li><li>CP-Select 624CB</li><li>007-624</li><li>ZM-624</li></ul>

Thermo Scientific Trace™ TR-WAX GC Columns

Analyze a wide range of polar compounds with the Thermo Scientific™ TRACE™ TR-Wax GC Column.

Analyze a wide range of polar compounds with the Thermo Scientific™ TRACE™ TR-Wax GC Column. A polyethylene-glycol-based phase ideal for the analysis of all polar compounds, it is highly cross-linked and fully deactivated to provide excellent peak shape even with short chain alcohols.<h4>Engineered for Superior Performance</h4><ul><li>Polar phase, polyethylene glycol</li><li>Highly cross-linked and fully deactivated</li><li>Solvent washable</li></ul><h4>Excellent Quality and Reproducibility:</h4><ul><li>Low-bleed even at elevated temperatures</li><li>Outstanding robustness for difficult separations</li><li>Reliable and reproducible performance</li></ul><h4>Applications:</h4><ul><li>Esters</li><li>Alcohols</li><li>Ketones</li><li>Glycols</li><li>Aromatic isomers</li></ul><h4>Recommended Use:</h4><ul><li>Aldehydes</li><li>Essential Oils</li></ul><h4>Alternative Uses:</h4><ul><li>Acids</li><li>Alcohols</li><li>Alcohols in beverages</li><li>Alditol acetates (sugars)</li><li>Amines–Aliphatic</li><li>Amines–Aromatic</li><li>Herbicides</li><li>Ketones</li><li>Nitroaromatics</li><li>Phenols</li><li>Volatiles</li></ul><h4>Similar To:</h4><ul><li>DB-Wax</li><li>BP20</li><li>Rtx™-Wax</li><li>Stabilwax™</li><li>HP20M</li><li>HP-Wax</li><li>HP-INNOWax</li><li>SUPELCOWAX™ 10</li><li>AT™-Wax</li><li>Nukol™</li><li>CP Wax52CB</li><li>SUPEROX II</li><li>Carbowax™</li><li>PE-WAX</li><li>ZBWAX</li></ul>

Thermo Scientific Trace™ TR-WaxMS GC Columns

For high-polarity separations as part of GC/MS analysis, choose the low-bleed, high polarity Thermo Scientific™TRACE™ TR-WaxMS GC Column. 

For high-polarity separations as part of GC/MS analysis, choose the low-bleed, high polarity Thermo Scientific™TRACE™ TR-WaxMS GC Column. The TRACE TR-WaxMS column is manufactured using a proprietary bonding technique that minimizes bleed and extends the maximum operating temperature (260 to 280 ̊C).<h4>Engineered for Superior Performance:</h4><ul><li>Polar phase, polyethylene glycol</li><li>Proprietary bonding method for expanded operating temperatures</li><li>Extremely low-bleed for improved sensitivity and library matches</li><li>High stability with oxygen and water</li></ul><h4>Excellent Quality and Reproducibility:</h4><ul><li>Low-bleed even at elevated temperatures</li><li>Outstanding robustness for difficult separations</li><li>Reliable and reproducible performance</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Trace_TR_Wax_MS_GC_Columns_676d6b9e2e.jpg" alt="Thermo Scientific: Trace™ TR-WaxMS GC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Trace_TR_Wax_MS_GC_Columns_676d6b9e2e.jpg 244w," sizes="100vw" width="650" height="416"><h4>Applications:</h4><ul><li>Aromatic hydrocarbons</li><li>Food additives</li><li>Essential oils</li><li>Alcohols</li><li>Esters</li><li>Aldehydes</li><li>Ketones</li></ul><h4>Recommended Use:</h4><ul><li>Aldehydes</li><li>Essential Oils</li></ul><h4>Alternative Uses:</h4><ul><li>Acids</li><li>Alcohols</li><li>Alcohols in beverages</li><li>Alditol acetates (sugars)</li><li>Amines&amp;endash;Aliphatic</li><li>Amines&amp;endash;Aromatic</li><li>Herbicides</li><li>Ketones</li><li>Nitroaromatics</li><li>Phenols</li><li>Volatiles</li></ul><h4>Similar To:</h4><ul><li>DB-Wax</li><li>Rtx™-Wax</li><li>Stabilwax™</li><li>HP20M</li><li>BP20</li><li>HP-Wax</li><li>HP-INNOWax</li><li>SUPELCOWAX™ 10</li><li>AT™-Wax</li><li>Nukol™</li><li>CP Wax 52CB</li><li>ZB-Wax</li></ul>

Thermo Scientific Trace™ TR-FAME GC Columns

Choose Thermo Scientific™ TRACE™ TR-FAME GC Columns for separation of cis/trans isomers and fatty acid methyl esters (FAMEs) with various degrees of unsaturation.

Choose Thermo Scientific™ TRACE™ TR-FAME GC Columns for separation of cis/trans isomers and fatty acid methyl esters (FAMEs) with various degrees of unsaturation. The TRACE TR-FAME column is a cyanopropylphenyl-based phase specifically designed for the separation of FAMEs. It is also suitable for any application that requires a high-polarity column for use with MS detection.<h4>Excellent Quality and Reproducibility</h4><ul><li>Low bleed for MS, even at elevated temperatures</li><li>Outstanding robustness for difficult separations</li><li>Reliable and reproducible performance</li><li>Polar phase, 70% cyanopropyl polysilphenylene-siloxane</li><li>Higher operating temperature than other columns</li></ul><h4>Applications:</h4><ul><li>FAMEs</li><li>FAMEs cis/trans isomers</li></ul><h4>Similar To:</h4><ul><li>DB-23</li><li>BPX70</li><li>Rtx™-2330</li><li>SP™-2330</li><li>CP-Sil 88</li><li>SP™-2380</li><li>HP-23</li><li>VF-23ms</li><li>007-23</li><li>AT™-Silar</li><li>PE-23</li></ul>

Thermo Scientific Trace™ TR-FFAP GC Columns

Low-bleed even at elevated temperatures. Chose the Thermo Scientific™ TRACE™ TR-FFAP GC Columns for outstanding robustness in difficult-to-analyze separations.

Low-bleed even at elevated temperatures. Chose the Thermo Scientific™ TRACE™ TR-FFAP GC Columns for outstanding robustness in difficult-to-analyze separations.<h4>Engineered Specifically for FFAP Analysis:</h4><ul><li>Polar phase, TPA modified polyethylene glycol</li><li>Bonded FFAP phase</li><li>Quality tested for acidic compound analysis</li><li>Equivalent to USP G25 and G35</li><li>Excellent Quality and Reproducibility</li><li>Low-bleed even at elevated temperatures</li><li>Outstanding robustness for difficult-to-analyze separations</li><li>Reliable and reproducible performance</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Trace_TR_FFAP_GC_Columns_56b870dff4.jpg" alt="Thermo Scientific: Trace™ TR-FFAP GC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Trace_TR_FFAP_GC_Columns_56b870dff4.jpg 244w," sizes="100vw" width="650" height="416"><h4>Recommended Use:</h4><ul><li>Acids</li><li>FFAP analysis</li><li>Alcohols</li></ul>

Thermo Scientific SII for Empower Software

Incorporate and operate Thermo Scientific UHPLC, HPLC, GC, and IC instruments within other vendors' software platforms with the Thermo Scientific™ SII for Empower 3 Software plug-in.

<div id="product-description">Incorporate and operate Thermo Scientific UHPLC, HPLC, GC, and IC instruments within other vendors' software platforms with the Thermo Scientific™ Standard Instrument Integration (SII) for Empower 3 Software plug-in. The SII for Empower 3 plug-in is based on the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</a> and offers unique and smart features that deliver maximum ease-of-use, reliability, and performance. It also enables Thermo Scientific™ chromatography systems to be operated and controlled by <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Waters™ Empower™ 3 CDS software</a>.</div><div>While Chromeleon CDS is the recommended software for control of Thermo Scientific UHPLC, HPLC, GC, and IC instruments due to its maximum ease of use, reliability, and performance, other vendors' CDS software can also incorporate and operate these instruments with the SII for Empower™ 3 Software plug-in.The SII for Empower™ Software installs and uses portions of <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a>, such as the Services Manager, Instrument Configuration Manager, Instrument View, and Instrument Method Editor, to deliver flawless integration of Thermo Scientific LC, IC, and GC instrumentation into Empower™ 3 CDS without loss of functionality. Instrument control, data acquisition, and data processing are performed completely under Empower™ 3 Software.Configure your instruments Up to four instruments can be configured per Empower™ node using the standard Chromeleon Instrument Configuration Manager.Control your instruments SII for Empower™ Software provides a complete set of commands because they are present under native Chromeleon CDS control. For the user, this means that all the Chromeleon CDS tools and advanced features, such as preparing the next sample during an ongoing analysis, can be implemented to increase productivity and receive more data with fewer injections.SII for Empower™ controls the following systems:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=37&amp;manufacturerItems=3&amp;search=Vanquish">Thermo Scientific™ Vanquish™ HPLC and UHPLC systems</a></li><li>Thermo Scientific™ UltiMate™ 3000 HPLC systems</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/410">Thermo Scientific™ Dionex™ ICS-6000 HPIC™ system</a></li><li>Thermo Scientific™ Dionex™ ICS-5000 HPIC™ system</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/408">Thermo Scientific™ Dionex™ Integrion™ HPIC™ system</a></li><li>Thermo Scientific™ Dionex™ Aquion™ system</li><li>Thermo Scientific™ TRACE™ 1300 GC systems</li></ul>Monitoring instrument status within Empower™ can be performed using the Empower™ Control Panel. Here, an enhanced SII Instrument View is easily accessed to provide further options to control and monitor the instrument and its modules.Instrument Methods Setting up an instrument method is simple, intuitive, and fast due to the SII for Empower™ Instrument Method Wizard and Editor, both of which are integrated into the Instrument Method Editor of Empower™. The wizard guides the user through all modules, enabling the entry of all necessary information, while the editor allows the review and modification of all aspects of a method.Process your data Complete data processing takes place inside Empower™ Software, which allows you to use all functionalities as you would normally, for example, overlay of chromatograms or other channels like pressure traces. The Empower™ user experience does not change for any data processing aspect.</div>

Thermo Scientific™ Chromeleon™ XPS Open Access Software

Thermo Scientific™ Chromeleon™ XPS provides streamlined and easy-to-use interface for Thermo Scientific™ Chromeleon™ CDS, while maintaining full capabilities of the CDS software.

In modern laboratories, chromatography techniques and the use of mass spectrometry (MS) detection are in high demand. Until recently, MS detectors were regarded as sophisticated detection tools that could be operated only by a highly trained specialist. Nowadays mass spectrometers are increasingly used as straightforward detectors for chromatography.Alongside this move into routine use of MS is the continued deskilling of staff in the laboratory world, causing highly experienced chromatographers to be in short supply. The result is a substantial number of regular scientists and process operators that need to generate chromatographic results using advanced instrumentation themselves.The solution is an Open Access tool enabling users to simply walk up and use a very straightforward interface to exploit the full power of the chromatography data system (CDS), without actually using the CDS software itself. Thermo Scientific™ Chromeleon™ XPS provides this streamlined and easy-to-use interface for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ CDS</a>, while maintaining full capabilities of the CDS software, like instrument control, data processing, reporting and compliance tools.<h3>Workflow</h3>Users can walk up to any chromatography instrument connected to the CDS, with or without MS detection, and start to run their analysis with only a few mouse-clicks.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_5e8f8c3dec.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: First, select the analysis to perform (A) and which instrument should be used (B). The instrument overview shows the current instrument status’ and displays the estimated wait time until each instrument is available and the number of sample positions still available. The instrument list is filtered depending on the analysis selected and the users privileges to only show appropriate instruments." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_5e8f8c3dec.jpg 196w," sizes="100vw" width="876" height="697"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_2_a8b64a52ae.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: Next, enter the sample names (C) and any other parameters (D) required for the analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_2_a8b64a52ae.jpg 196w," sizes="100vw" width="876" height="697"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_3_4b4367ffae.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: Place the sample vials in the indicated positions and select Submit." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_3_4b4367ffae.jpg 196w," sizes="100vw" width="876" height="697"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_4_0386d31c9a.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: The sequence is submitted and will run. The operator is shown the expected start and finish time of the analyses." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_4_0386d31c9a.jpg 245w," sizes="100vw" width="625" height="263"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_5_1b51ab8dd2.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: At the end of the run, the results are automatically printed and/or exported and a link to the exported report can be distributed via email." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_5_1b51ab8dd2.jpg 245w," sizes="100vw" width="814" height="309"><h3>Configuration and management</h3>Running samples is as easy as described above once Chromeleon XPS software is set up, configured and managed by an experienced chromatographer.<ul><li>All the methods required for the analysis must be created; the instrument method with all instrument control and data acquisition parameters, the processing method with all data processing parameters and the report template with all required results, to be reported.&nbsp;</li><li>A Chromeleon eWorkflow is created using these methods. An eWorkflow is an electronic procedure that automates all steps of the laboratory process related to a chromatographic analysis</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_6_a3b2219e42.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: The lab manager can customize Chromeleon XPS to show or hide individual toolbar buttons (A), which eWorkflows are visible to users (B) and which instruments they can access (C)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_6_a3b2219e42.jpg 196w," sizes="100vw" width="876" height="697"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_7_d647111f5d.jpg" alt="Thermo Scientific™ Chromeleon™ XPS Open Access Software: In addition, it is possible to define various system options, such as which email notifications to send." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_XPS_Open_Access_Software_7_d647111f5d.jpg 193w," sizes="100vw" width="659" height="533">Chromeleon XPS Open Access software lets any user run samples on their own by delivering a clean, streamlined walk-up interface that utilizes the full power of Chromeleon CDS. Users can access all instruments controlled by <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a>, including MS, and automatically receive results or notifications about run completion or failure. The management console contains advanced customization options to fulfill any organization’s requirements, included fully regulated environments.Chromeleon XPS software provides error-free execution of any chromatography analysis with minimal training requirements for users.

Thermo Scientific SureSTART Vials and Well Plates Collection

Start your analysis with confidence using SureSTART vials, caps, well plates, and kits—offering full compatibility, quality materials, and performance across three levels.

<h4>Streamlined choice. Trusted quality.</h4>Start your analysis with confidence using Thermo Scientific™ SureSTART™ vials, caps, inserts, well plates, mats, and certified kits designed to meet your analytical, regulatory, and performance requirements. With full instrument compatibility, high material quality, and consistent performance across three defined levels, the SureSTART collection offers a smarter way to choose the right sample containment solution for your workflow.<h3>Why choose SureSTART?</h3><ul><li>Proven reliability: Every product is manufactured and certified to meet physical specifications—no weak links in your workflow.</li><li>Clear selection: Three performance levels help you balance sensitivity, robustness, and cost, now visually marked with one, two, or three waves on the vial.</li><li>Universal compatibility: Designed for seamless integration with all major GC, HPLC/UHPLC, and MS autosamplers across all vendors.</li><li>Certified cleanliness: Products are manufactured using the purest glass and plastics with low extractables and leachables, including GOLD-grade and silanized glass.</li><li>Maximum sample integrity: Minimize analyte loss and background peaks with precision-engineered sealing, surface chemistry, and material composition.</li><li>Bulk savings &amp; simplified inventory: Available in multiple pack sizes, performance levels, and formats to support your lab’s needs and budget.</li></ul><h3>The Three Performance Levels</h3><ul><li>Level 1 – Everyday analysis: For general-purpose GC/HPLC detection (e.g. UV/Vis, FID, RI). These chromatography-approved products are ideal for routine analyses with cost-efficiency in mind.</li><li>Level 2 – High-throughput analysis: Designed for regulated labs requiring robust and reproducible data, especially when using MS detectors for routine quantification.</li><li>Level 3 – High performance: For the most sensitive and selective analyses near the method detection limit. Packed in cleanroom environments and made with ultra-pure materials for maximum sample security and MS compatibility.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Sure_START_Vials_and_Well_Plates_Collection_5a8b0da936.jpg" alt="Thermo Scientific SureSTART Vials and Well Plates Collection: Three performance levels help you balance sensitivity, robustness, and cost, now visually marked with one, two, or three waves on the vial." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Sure_START_Vials_and_Well_Plates_Collection_5a8b0da936.jpg 245w," sizes="100vw" width="1182" height="270"><h3>SureSTART Certified Vial and Cap Kits</h3><ul><li>Specification Certified: Routine analyses – Certified for physical specifications; no individual certificate.</li><li>LC/GC Certified: Chromatography-grade – Tested for 15 physical parameters with LC-UV &amp; GC-FID; certificate included.</li><li>MSCERT: For LC-MS/GC-MS – Certified low-adsorption kits tested with MS; includes SureStop™ vials with AVCS™ caps.</li><li>MSCERT+: For trace-level MS or DIA – Pre-cleaned, tested with LC-MS/GC-MS, and sold only as kits to ensure purity.</li><li>Application Certified: Pre-matched kits for specific instruments or validated applications.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Sure_START_Vials_and_Well_Plates_Collection_2_fef6049d71.jpg" alt="Thermo Scientific SureSTART Vials and Well Plates Collection: There are several factors to consider when choosing a vial or well plate for your application. The table below will help guide you through this process to determine what type of product/performance level is most suitable for your application requirements." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Sure_START_Vials_and_Well_Plates_Collection_2_fef6049d71.jpg 204w," sizes="100vw" width="1515" height="1159"><h3>SureSTART Well Plates and Mats</h3>Thermo Scientific™ WebSeal™ well plates are ideal for laboratories seeking to increase autosampler capacity, reduce solvent usage, and streamline high-throughput workflows. Available in 96- and 384-well formats, they offer a certified alternative to traditional vials and are fully compatible with automated SPE/SLE platforms.<ul><li>Space-saving efficiency: Replace vials with well plates to increase sample capacity up to 8× and reduce storage footprint.</li><li>Flexible performance levels:<ul><li>Level 1: Standard plates for routine, non-regulated use (GC-tested).</li><li>Level 2: Low-bleed plates and high-performance mats, validated for LC-MS/GC-MS.</li><li>Level 3: Premium WebSeal Plate+ with glass-coated plastic wells—ideal for trace analytes and protein adsorption control.</li></ul></li><li>Solvent stability and clean sample contact: WebSeal Plate+ uses nanolayered silicon dioxide for minimal extractables and ultra-low adsorption.</li><li>Compatible sealing options:<ul><li>Silicone mats: For long-term storage and consistent results.</li><li>Pre-slit mats: For autosampler injection without evaporation or contamination.</li><li>Adhesive seals: For single-use workflows and re-sealing options with cavity protection.</li></ul></li></ul>Whether you work with polar solvents, proteins, or trace-level analyses, SureSTART well plates and sealing accessories help you optimize throughput, precision, and data confidence across all chromatography workflows.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Sure_START_Vials_and_Well_Plates_Collection_3_abce3dd960.jpg" alt="Thermo Scientific SureSTART Vials and Well Plates Collection: Selecting the perfect Thermo Scientific WebSeal well plates and mats for your chromatography requirements is easy using our selector tools and resources." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Sure_START_Vials_and_Well_Plates_Collection_3_abce3dd960.jpg 245w," sizes="100vw" width="1516" height="902">

Thermo Scientific MarqMetrix All-In-One X Process Raman Analyzer

Compact, portable Thermo Scientific MarqMetrix All-In-One X Process Raman analyzer for real-time, intrinsically safe process analysis in hazardous locations, enabling fast, non-destructive measurement of gases, liquids, and solids.

The Thermo Scientific MarqMetrix All-In-One X Process Raman Analyzer is a compact, portable Raman spectrometer engineered for real-time compositional analysis in hazardous locations. Designed for ease of use and rapid deployment, it delivers inherently and intrinsically safe operation where fast, confident decision-making is critical.<h4>Designed for hazardous environments</h4>Purpose-built for hazardous locations, the analyzer provides intrinsically safe optical power and on-site, real-time compositional insights. This enables operators to make faster, safer, and more informed decisions directly at the point of measurement.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_2_f4280a5f55.jpg" alt="Thermo Scientific MarqMetrix All-In-One X Process Raman Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_2_f4280a5f55.jpg 229w," sizes="100vw" width="650" height="442"><h4>Applications</h4>The analyzer is ideal for industries requiring fast and accurate results, including:<ul><li>Midstream and downstream oil &amp; gas operations</li><li>Chemical and polymer processing</li><li>Pharmaceutical development and manufacturing</li></ul><h4>Designed for use in hazardous locations</h4>The MarqMetrix All-In-One X Process Raman Analyzer supports probes engineered for safe operation in hazardous environments and compliant with ATEX Zone 0, IECEx, and Class I Division 1 certifications. These probes enable real-time analysis of gases, liquids, and solids using a single analyzer.Available probe options include:<ul><li>Thermo Scientific MarqMetrix FlowCell Sampling Optic Designed for seamless integration into continuous flow processes, this optic enables highly accurate Raman measurements without proprietary hardware. It connects easily to existing flow paths using standard industry fittings.</li><li>Thermo Scientific MarqMetrix Process BallProbe Sampling Optic Engineered for extreme environments, this probe is constructed from Hastelloy® C-276 for exceptional durability in harsh chemical and high-temperature conditions. Available in multiple diameters and chassis lengths, it delivers reliable in-line measurements for demanding applications.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_5_46cbbadfe8.jpg" alt="Thermo Scientific MarqMetrix All-In-One X Process Raman Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_5_46cbbadfe8.jpg 245w," sizes="100vw" width="650" height="327"><h4>Simple, non-destructive analysis</h4>The analyzer streamlines process analysis by eliminating the need for sample preparation and enabling fast, non-destructive, and non-invasive measurements. Its intuitive design allows straightforward setup and operation, even for users without prior spectroscopy experience. Factory calibration ensures consistent, high-precision measurements from the start, supporting scalable deployment across multiple instruments.<h4>Software and connectivity</h4>The system includes a comprehensive Raman software suite for spectral acquisition, visualization, chemometric model application, and real-time trend analysis. A dedicated integration software package supports seamless connectivity with industrial and process control systems via the Modbus communication protocol.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_4_bc7cefcb24.jpg" alt="Thermo Scientific MarqMetrix All-In-One X Process Raman Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_4_bc7cefcb24.jpg 245w," sizes="100vw" width="650" height="413"><h4>Specifications</h4><ul><li>Certifications / Compliance: Laser Certification: Class 3B laser device, reported to the FDA</li><li>Dark Noise: ≤16.5 counts at 10 s integration</li><li>Depth (Metric): 25 cm</li><li>Detector: Thermally stabilized CCD (2-stage TEC)</li><li>Fiber Conditions: FC/PC (both excitation and collection)</li><li>Height (Metric): 11.4 cm</li><li>Includes: Wireless mouse, HDMI cable, and monitor</li><li>Laser Power:<ul><li>Laser excitation wavelength: 785 nm</li><li>Excitation power: 35 mW (maximum allowable laser energy in ATEX Zone 0 environments)</li></ul></li><li>Operating Temperature Range: 15 °C to 30 °C</li><li>Resolution: 6.5 cm⁻¹ average across spectral range</li><li>Safety Features:&nbsp;<ul><li>1 keyed laser interlock switch</li><li>electronic laser trigger</li></ul></li><li>Software Details: MarqMetrix All-In-One Process Raman Analyzer Raman suite</li><li>Spectral Range: 100 to 3250 cm⁻¹</li><li>Width (Metric): 25 cm</li><li>Type: Raman spectrometer</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_3_57b8fa48b9.jpg" alt="Thermo Scientific MarqMetrix All-In-One X Process Raman Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_3_57b8fa48b9.jpg 243w," sizes="100vw" width="650" height="418">

Thermo Scientific DXR3 Raman Microscope

The Thermo Scientific DXR3 Raman Microscope is an easy-to-use confocal Raman system with automated calibration, high stability, and flexible laser options for a wide range of applications.

The Thermo Scientific™ DXR3 Raman Microscope is a modern, easy-to-use point-and-shoot Raman microscope designed to provide faster, more reliable access to Raman data than ever before. Advanced imaging capabilities combined with automated system calibration deliver exceptional stability, reproducibility, and confidence in Raman measurements—even for non-specialist users.Thanks to Automated X-axis Calibration, the DXR3 system maintains long-term accuracy and reliability while minimizing user intervention. With a flexible choice of lasers and gratings, the DXR3 Raman Microscope is ideally suited for applications across pharmaceutical research, academia, advanced polymers, microplastics, and many other demanding fields.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3_Raman_Microscope_6_1dd5de4a21.jpg" alt="Thermo Scientific DXR3 Raman Microscope" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3_Raman_Microscope_6_1dd5de4a21.jpg 245w," sizes="100vw" width="650" height="299"><h3>Key capabilities</h3><ul><li>New Particle Analysis functionality for rapid identification and analysis of microparticles</li><li>High-performance confocal Raman microscopy in a robust, fully integrated design</li><li>Fully automated alignment and calibration with no tools or manual procedures required</li><li>Real-time preview, automated fluorescence correction, auto-exposure, and cosmic ray rejection</li><li>System status indicator providing at-a-glance confirmation that the instrument is optimized and ready for data acquisition</li><li>Three-path fine-beam autoalignment to maintain peak performance and sampling integrity</li><li>Active laser power regulation ensuring consistent sample excitation throughout the lifetime of the laser</li><li>Advanced spectrograph design with no moving parts for simplified operation and highly robust detection and calibration</li><li>Pre-aligned, lock-in-place components with automatic recognition and stored alignment, enabling system reconfiguration in seconds</li><li>Interchangeable lasers and components shared across the DXR3 Raman family</li><li>Optional automated polarized Raman spectroscopy for structural information complementary to chemical data</li><li>Add new excitation wavelengths without tools or service engineer intervention</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3_Raman_Microscope_2_e366caa151.jpg" alt="Thermo Scientific DXR3 Raman Microscope" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3_Raman_Microscope_2_e366caa151.jpg 204w," sizes="100vw" width="631" height="483"><h3>Laser safety</h3><ul><li>Microscope independently certified as Class 1 laser safe (Note: optional fiber-optic accessories and certain other optional components are Class 3B laser devices and require appropriate laser safety precautions and eyewear)</li><li>Laser is physically blocked from the visual viewing path, preventing eye exposure during sample observation</li></ul><h3>Validation and compliance</h3><ul><li>Complete DQ/IQ/OQ/PQ validation package available, including extensive documentation and automated software protocols</li><li>OMNIC™ D/S software supports compliance with 21 CFR Part 11</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3_Raman_Microscope_3_62f6baad12.jpg" alt="Thermo Scientific DXR3 Raman Microscope" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3_Raman_Microscope_3_62f6baad12.jpg 178w," sizes="100vw" width="630" height="553"><h3>Exceptional analytical performance</h3><ul><li>Spatial resolution down to 540 nm on ideal samples</li><li>Confocal depth resolution as fine as 1.7 µm on ideal samples</li><li>Full spectral range of 3500–50 cm⁻¹ captured in a single CCD exposure, eliminating stitching artifacts</li><li>Extended spectral range up to 6000 cm⁻¹ available with the 532 nm laser</li><li>Support for multiple excitation lasers: 455, 532, 633, and 785 nm (high-brightness and high-power options)</li><li>Automatic fluorescence correction available for all excitation lasers</li><li>Research-grade Olympus viewing optics</li><li>Automatic intensity correction enabling spectral comparability between instruments and across different excitation lasers</li><li>Multidimensional wavelength calibration ensuring accurate calibration across the entire spectral range</li><li>Proprietary Triplet spectrograph delivering exceptional peak shape and maintaining focus at all wavelengths</li><li>Software-controlled switching between confocal and high-energy collection modes</li><li>Proprietary algorithms for automated cosmic ray rejection and high-quality laser line filters for artifact-free spectra</li><li>Depolarized lasers to eliminate confusing sample orientation effects</li><li>Active laser power monitoring ensures reproducible excitation power over the laser lifetime and after laser replacement</li><li>Optimized gratings for each excitation laser, avoiding performance compromises associated with shared gratings</li><li>Proprietary autoalignment maintains the system in like-new condition</li><li>Smart-Backgrounds technology automatically removes the CCD dark energy profile</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3_Raman_Microscope_5_ca01560747.jpg" alt="Thermo Scientific DXR3 Raman Microscope" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3_Raman_Microscope_5_ca01560747.jpg 210w," sizes="100vw" width="633" height="471"><h3>Recommended applications</h3><ul><li>Forensics – trace evidence analysis and illicit drug identification</li><li>Pharmaceuticals – polymorphism studies, particulate contamination, and diffusion analysis</li><li>Art restoration and conservation – identification and characterization of pigments, resins, glazes, and inks</li><li>Archaeology – characterization of horn, shell, bone, and ceramic artifacts</li><li>Solar materials – silicon crystallinity and photovoltaic material characterization</li><li>Polymers – inclusions, gel defects, weathering effects, laminate layers, and crystallinity</li><li>Failure analysis – characterization of particulates and small surface features</li><li>Gemology – rapid identification of colored stones, differentiation of natural and synthetic diamonds, characterization of inclusions and adulterants</li><li>Nanotechnology – graphene, carbon nanotubes (CNTs), DLC coatings, and other nanostructures</li><li>Academic research – materials science, biological studies, and a wide range of applied research fields</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3xi_Raman_Imaging_Microscope_9_5d3708416c.jpg" alt="Thermo Scientific DXR3 Raman Microscope" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3xi_Raman_Imaging_Microscope_9_5d3708416c.jpg 156w," sizes="100vw" width="650" height="650"><h3>Specification</h3><ul><li>Depth (Metric): 68 cm</li><li>Description: DXR3 Raman Microscope</li><li>Electrical Requirements: 100/240 V, 47/63 Hz</li><li>Electronic Records and Signatures: 21CFR Part 11</li><li>For Use With (Application):&nbsp;<ul><li>Pharmaceutical</li><li>Microplastics</li><li>Forensics</li><li>Polymer/Chemical</li><li>Petrochemical</li><li>Material Science</li><li>Nanomaterials</li><li>Academia</li><li>Energy Storage</li><li>Art Restoration/Conservation</li></ul></li><li>Height (Metric): 61 cm</li><li>Laser Power: Fine Laser Power Control: Power controlled and reported at samples in 0.1 mW increments</li><li>Model: DXR3</li><li>Operating Temperature Range: 16°C to 27 °C</li><li>Resolution:&nbsp;<ul><li>Spatial: 1 µm</li><li>Confocal Depth: 2 µm</li></ul></li><li>Wavelength Range:&nbsp;<ul><li>455 nm</li><li>532 nm high brightness</li><li>532 nm high power</li><li>633 nm high brightness</li><li>633 nm high power</li><li>780 nm</li></ul></li><li>Weight (Metric): 66.5 kg</li><li>Width (Metric): 94 cm</li><li>Type: Microscope</li><li>Unit Size: Each</li></ul>

Products from Thermo Fisher Scientific - page 2

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