<p><strong>Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular mechanism by which the transcription of genetic information from deoxyribonucleic acid (DNA) into ribonucleic acid (RNA) can be initiated. The researchers focused on a specific class of molecules known as alarmones, which are found in cells across a wide range of organisms and whose levels often increase under conditions of cellular stress. The results were published in the prestigious scientific journal </strong><i><strong>Nature Chemical Biology</strong></i><strong>.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Hana Cahová, head of the Chemical Biology of Nucleic Acids research group." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Molecules of ribonucleic acid can carry a variety of chemical modifications at one end, known as caps. In eukaryotic organisms, including human cells, the best-known cap plays an important role in RNA stability and in regulating its subsequent fate. In recent years, however, it has become clear that alternative, non-canonical RNA caps also exist, although their formation and the mechanisms by which they are attached to RNA remain only partially understood. These include alarmone caps, formed by dinucleoside polyphosphate molecules, that protect cellular RNA at moments when the cell is under threat.</p><p>In their study,<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://cahova.group.uochb.cz/en"><strong>Dr. Hana Cahová</strong></a> and colleagues examined bacterial RNA polymerase and investigated how this enzyme can initiate transcription using dinucleoside polyphosphates (NpNs) instead of the standard RNA building blocks. For the first time, the scientists described, at the atomic level, how RNA bearing an alarmone cap can be generated directly at the initiation of gene transcription. They also observed that NpNs bind through a different type of base pairing than is typically observed.</p><p>The work was significantly shaped by <strong>Valentina Serianni from Hana Cahová’s team</strong>, who demonstrated the ability of dinucleoside polyphosphates to initiate gene transcription, and by <strong>Jana Škerlová</strong>, who focused on the structural analysis of RNA polymerase. Using cryogenic electron microscopy data, she showed how dinucleoside polyphosphate molecules bind within the active site of RNA polymerase – that is, the core of the enzyme where genetic information is transcribed. Together, their findings help to elucidate the processes that accompany the transcription of genetic information from DNA to RNA.</p><p>Hana Cahová adds: <i>“We’re describing something that truly occurs in cells and that we’re now able to observe directly at the level of individual molecules. This allows us to answer fundamental questions about cellular processes, such as how cells adapt to stress. RNA plays a central role in this, as it carries the cascade of information underlying any cellular response – for example, to threatening conditions caused by nutrient deprivation or temperature shock.”</i></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Tomáš Kouba, head of the Cryogenic Electron Microscopy core facility." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Cryogenic electron microscopy (cryo-EM) was central to the project. This part of the work was led by<strong> Dr. Tomáš Kouba</strong>, one of the authors of the study. <i>“Cryogenic electron microscopy allows us to freeze biological molecules in a state very close to their natural form and then determine their three-dimensional structure. This makes it possible to look directly into the active centers of enzymes and observe their function down to the atomic level,”</i> he explains.</p><p>Last year, IOCB Prague opened a new <a target="_blank" rel="noopener noreferrer" href="https://cryoem.group.uochb.cz/en"><strong>cryo-EM center</strong></a><strong> </strong>that is unique within the Czech research environment. State-of-the-art cryogenic electron microscopes are housed in a specially designed building and enable the study of biological processes with exceptional structural precision.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg" alt="IOCB Prague: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: This work shows how NpnNs initiate bacterial transcription. Cryo-EM reveals how nucleobases pair with the template: one in canonical and one in reverse Watson–Crick mode, providing a structural basis for their function as non-canonical RNA caps." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg 245w," sizes="100vw" width="2000" height="1077"></p><blockquote><h4><strong>The Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-025-02134-5"><strong>Molecular insight into 5′ RNA capping with Np<sub>n</sub>Ns by bacterial RNA polymerase</strong></a></h4><p>Valentina M. Serianni, Jana Škerlová, Anna Knopp Dubánková, Anton Škríba, Hana Šváchová, Tereza Vučková, Anatolij Filimoněnko, Milan Fábry, Pavlína Řezáčová, Tomáš Kouba &amp; Hana Cahova&nbsp;</p><p>Nat. Chem. Biol. 21 (2026)</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41589-025-02134-5">https://doi.org/10.1038/s41589-025-02134-5</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>RNA capped with dinucleoside polyphosphates has been discovered in bacteria and eukaryotes only recently. The likely mechanism of this specific capping involves direct incorporation of dinucleoside polyphosphates by RNA polymerase as noncanonical initiating nucleotides. However, how these compounds bind into the active site of RNA polymerase during transcription initiation is unknown. Here, we explored transcription initiation in vitro, using a series of DNA templates in combination with dinucleoside polyphosphates and model RNA polymerase from <i>Thermus</i> <i>thermophilus</i>. We observed that the transcription start site can vary on the basis of the compatibility of the specific template and dinucleoside polyphosphate. Cryo-electron microscopy structures of transcription initiation complexes with dinucleoside polyphosphates revealed that both nucleobase moieties can pair with the DNA template. The first encoded nucleotide pairs in a canonical Watson–Crick manner, whereas the second nucleobase pairs noncanonically in a reverse Watson–Crick manner. Our work provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription.</p></div></div>

Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription

<p><strong>In the week of February 9, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><div><div><div><div><div><div><h5><strong>1. Thermo Fisher Scientific: Process Raman – A Reliable and Versatile Tool for Downstream Process Monitoring and Control for mAb Production</strong></h5><ul><li>Tu, 10.2.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5808">Registration</a></li></ul><p>The presentation highlights how process Raman spectroscopy offers several advantages over traditional in-line UV-Vis analysis for process monitoring and metabolite production control in mAb manufacturing.</p><h5><strong>2. Wasson-ECE Instrumentation: The Data Driven Plant – How AI Transforms Chemical Manufacturing</strong></h5><ul><li>Tu, 10.2.2026 21:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5744">Registration</a></li></ul><p>Explore how artificial intelligence is applied to improve process efficiency, monitoring, and decision-making in modern chemical manufacturing.</p><h5><strong>3. New Food Magazine: The Science of Next-Gen Ingredients – Fermentation, Formulation and Function</strong></h5><ul><li>We, 11.2.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5720">Registration</a></li></ul><p>Discover how fermentation-driven innovation is transforming functional food ingredients, with analytical insights to optimize flavour, functionality, and product stability.</p></div></div></div></div></div></div>

Webinars LabRulezGCMS Week 07/2026

<p><strong>This study presents an analytical strategy combining QuEChERS extraction with low-temperature partitioning (LTP) for the determination of multiclass pesticide residues in cocoa beans by GC–MS. Extraction conditions were optimized using a fractional factorial design, resulting in a simple and efficient workflow suitable for complex cocoa matrices.</strong></p><p>The validated method showed satisfactory limits of detection and quantification, recoveries within 70–120%, and good overall performance. Application to cocoa samples from Brazil detected permethrin in several samples, demonstrating that the QuEChERS–LTP approach is an effective and reliable cleanup strategy for routine pesticide residue analysis in cocoa.</p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c10360"><strong>QuEChERS Combined with Low-Temperature Partitioning and GC–MS as an Analytical Strategy for the Determination of Multiclass Pesticide Residues in Cocoa Beans</strong></a></h4><p>Priscilla M. de Freitas Machado, Madson M. Nascimento, Paulo R. R. Mesquita, Manuela B. Nascimento, Lilian Lefol N. Guarieiro, Gisele O. da Rocha, Jailson B. de Andrade, Raildo M. de Jesus*</p><p>ACS Omega 2025, 10, 51, 63464–63473</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acsomega.5c10360">https://doi.org/10.1021/acsomega.5c10360</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><p><strong>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.</strong></p><p>Cocoa is best known as the primary raw material for chocolate but is also processed into products such as cocoa butter, biscuits, cocoa honey, and cocoa powder. Cocoa powder is derived from roasted, pressed, and milled nibs, containing on average 20% (w/w) lipids on a dry basis and less than 9% moisture. <a href="javascript:void(0);">(3,4)</a></p><p>According to the Brazilian Health Regulatory Agency (ANVISA), pesticides such as atrazine, bifenthrin, cyproconazole, metalaxyl, tebuconazole, trifloxystrobin, and permethrin are approved for use in Brazil. <a href="javascript:void(0);">(13)</a> However, among these, only metalaxyl, trifloxystrobin, and tebuconazole are authorized by the European Union. <a href="javascript:void(0);">(14)</a> Thus, investigating these contaminants in cocoa samples is of utmost importance, as Brazil is one of the largest cocoa exporters, supplying cocoa commodities to South America, the United States, and the European Union. <a href="javascript:void(0);">(2)</a> Furthermore, Organochlorine pesticides, in particular, belong to the class of persistent organic pollutants (POPs). Although banned in many countries, they continue to be used in some developing nations because of their chemical stability, resistance to degradation, volatility, and high lipophilicity, which promote bioaccumulation and neurotoxicity. <a href="javascript:void(0);">(15)</a> Epidemiological evidence also associates their exposure with Parkinson’s disease, certain cancers, diabetes, and endometriosis. <a href="javascript:void(0);">(16)</a></p><p>Residues of pesticides in cocoa have been reported in various studies. <a href="javascript:void(0);">(17)</a> Analyzing pesticide residues in cocoa presents analytical challenges due to the matrix’s complexity, comprising high lipid content, fatty acids and esters, sugars, polyphenols, and caffeine. These components can interfere with extraction efficiency and contaminate analytical instrumentation. <a href="javascript:void(0);">(18)</a> Therefore, efficient sample preparation methods incorporating effective cleanup steps are essential for accurate residue determination.</p><p>Several techniques have been employed for multiresidue pesticide analysis in cocoa. For instance, Idowu et al. <a href="javascript:void(0);">(19)</a> quantified 14 organochlorines using Soxhlet extraction and silica/Na<sub>2</sub>SO<sub>4</sub> cleanup, with GC ECD detection. Okoffo et al. <a href="javascript:void(0);">(20)</a> determined 13 organophosphates and 9 pyrethroids employing SPE cartridges (Envi-carb/LC-NH<sub>2</sub> and Bond Elute C18), acetonitrile extraction, and GC PFPD or GC ECD quantification. Yusiasih et al. <a href="javascript:void(0);">(21)</a> applied dispersive SPE with PSA, Florisil, and MgSO<sub>4</sub> for pyrethroids, followed by GC ECD and GC–MS.</p><p>Therefore, this study aimed to evaluate the effectiveness of a QuEChERS–LTP analytical procedure for the determination of multiclass pesticide residues in cocoa beans. The factors that affect the QuEChERS–LTP procedure efficiency were optimized. After validation, the procedure was employed to investigate the occurrence of 15 multiclass pesticides in cocoa samples.</p><h4><strong>Experimental Section</strong></h4><h5><strong>Instrumental Apparatus</strong></h5><p>Pesticide separation and identification were performed on a Shimadzu <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GC-MS-QP2010SE"><strong>GC-MS-QP2010SE</strong></a> system (Kyoto, Japan) equipped with an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=AOC-20i"><strong>AOC-20i autosampler</strong></a>. Separation was achieved using an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=DB-5MS"><strong>Agilent DB-5MS capillary column</strong></a> (30 m × 0.25 mm × 0.25 μm) with a stationary phase of 5% phenyl/95% dimethylpolysiloxane. The instrumental conditions were based on Nascimento et al. <a href="javascript:void(0);">(49)</a> and they are summarized in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c10360#tbl4">Table 4</a>.</p><p>For quantification, the base peak was used, while two additional ions were monitored for confirmation (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acsomega.5c10360/suppl_file/ao5c10360_si_001.pdf">Table S2</a>) in accordance with SANTE guidelines. <a href="javascript:void(0);">(50)</a> A GC–MS/SIM chromatogram illustrating the separation of all target pesticides is presented in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c10360#fig5">Figure 5</a>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2025_10_51_63464_63473_Figure_5_Extracted_ion_chromatogram_EIC_in_SIM_mode_of_the_target_pesticides_f2461c14f4.jpg" alt="ACS Omega 2025, 10, 51, 63464–63473: Figure 5. Extracted ion chromatogram (EIC) in SIM mode of the target pesticides obtained from the injection of a mixed standard solution at 100 μg L–1. Analytes are listed in order of elution: [1] Molinate (6.18 min); [2] α-HCH (8.15 min); [3] atrazine-d5 (8.69 min); [4] atrazine (8.75 min); [5] diazinon (9.31 min); [6] disulfoton (9.67 min); [7] dimethachlor (10.60 min); [8] metalaxyl (11.25 min); [9] p,p′-DDE (15.82 min); [10] cyproconazole I (16.50 min); [11] cyproconazole II (16.56 min); [12] p,p′-DDD (17.29 min); [13] ethion (17.34 min); [14] trifloxystrobin (18.43 min); [15] tebuconazole (19.13 min); [16] bifenthrin (20.47 min); [17] permethrin I (23.92 min); [18] permethrin II (24.18 min)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2025_10_51_63464_63473_Figure_5_Extracted_ion_chromatogram_EIC_in_SIM_mode_of_the_target_pesticides_f2461c14f4.jpg 245w," sizes="100vw" width="2080" height="835"></p><h5><strong>Application of the Proposed Procedure to Real Samples</strong></h5><p>In a 50 mL Falcon tube, 2.0 g of sample was weighed using an analytical balance (AUX320, Shimadzu, Kyoto, Japan). A total of 2.0 g of salt (NaCl and Na<sub>2</sub>SO<sub>4</sub> in a 1:1 w/w ratio) was added, followed by an aliquot of the atrazine-<i>d</i><sub>5</sub> solution (surrogate standard) to yield a final concentration of 250 μg kg<sup>–1</sup>. A mixture of acetonitrile (8.0 mL) and ultrapure water (2.0 mL) was then added. The system was vortexed (K40-10208, Kasvi, São Paulo, Brazil) for 3.0 min at 2500 rpm and centrifuged (MPW-351R, MPW Med. Instruments, Warsaw, Poland) for 10.0 min at 15 °C and 10,000 rpm. After phase separation, approximately 6.0 mL of the supernatant was transferred to a Falcon tube containing 150.0 mg of PSA sorbent. The mixture was vortexed again for 3.0 min at 2500 rpm and centrifuged for an additional 10.0 min under the same conditions. The tubes were then placed in the freezer for 24 h. Once the aqueous phase had frozen, the organic extract containing the analytes was collected, filtered through a Cytiva Whatman MiniUniprep G2 vial with a 0.20 μm membrane filter (Marlborough, Massachusetts, USA), and injected into the GC–MS system (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c10360#fig6">Figure 6</a>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2025_10_51_63464_63473_Figure_6_Schematic_representation_of_the_extraction_procedure_using_the_Qu_E_Ch_ERS_LTP_procedure_for_pesticide_extraction_in_cocoa_powder_samples_ed58549bcf.jpg" alt="ACS Omega 2025, 10, 51, 63464–63473: Figure 6. Schematic representation of the extraction procedure using the QuEChERS–LTP procedure for pesticide extraction in cocoa powder samples." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2025_10_51_63464_63473_Figure_6_Schematic_representation_of_the_extraction_procedure_using_the_Qu_E_Ch_ERS_LTP_procedure_for_pesticide_extraction_in_cocoa_powder_samples_ed58549bcf.jpg 223w," sizes="100vw" width="1458" height="1022"></p><h4><strong>Results and Discussion</strong></h4><h5><strong>Evaluation of the Effect of Low and Ultralow Temperatures on the Analytical Response</strong></h5><p>Studies reporting the use of LTP generally employ a conventional freezer, which typically reaches −18 ± 2 °C as the minimum temperature. In this equipment, effective phase separation can require 8 to 24 h. <a href="javascript:void(0);">(35−37)</a> In contrast, ultralow temperature freezers (ultrafreezers) can reach −80 °C, leading to a substantial reduction in partitioning time. In this study, tests performed with the conventional freezer achieved satisfactory partitioning after 24 h, whereas in the ultrafreezer, complete partitioning was observed in only 20 min.</p><p>Considering the analytical response in terms of peak area (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c10360#fig3">Figure 3</a>), higher signals were obtained when LTP was performed in a conventional freezer rather than an ultrafreezer. This behavior can be attributed to the partitioning mechanism. <a href="javascript:void(0);">(32)</a> Partitioning depends on cooling and the subsequent freezing of the aqueous phase. In the conventional freezer, the slower freezing rate provides sufficient time for the system to approach thermodynamic equilibrium, favoring analyte diffusion between phases. Under these conditions, analyte molecules have more time to migrate and distribute optimally before complete solidification. In contrast, the rapid freezing in the ultrafreezer may trap analytes in a nonideal distribution, reducing the efficiency of the partitioning process <a href="javascript:void(0);">(32)</a> (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c10360#fig3">Figure 3</a>). According to these observations, the conventional freezer was selected for subsequent experiments.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2025_10_51_63464_63473_Figure_3_Comparison_of_chromatographic_peak_areas_of_pesticides_after_partitioning_in_the_conventional_freezer_versus_the_ultrafreezer_9598bcfec3.jpg" alt="ACS Omega 2025, 10, 51, 63464–63473: Figure 3. Comparison of chromatographic peak areas of pesticides after partitioning in the conventional freezer versus the ultrafreezer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2025_10_51_63464_63473_Figure_3_Comparison_of_chromatographic_peak_areas_of_pesticides_after_partitioning_in_the_conventional_freezer_versus_the_ultrafreezer_9598bcfec3.jpg 175w," sizes="100vw" width="996" height="891"></p><h5><strong>Application to Real Samples</strong></h5><p>Fifteen samples were analyzed in triplicate, comprising two from the State of Pará and 12 from the State of Bahia, located in the North and Northeast regions of Brazil, respectively. Among the 15 pesticides investigated, only permethrin isomers were quantified in four samples (<a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c10360#tbl3">Table 3</a>). The herbicide molinate was also detected in three samples; however, its concentration was below LOQ. Permethrin isomers concentrations ranged from 17.1 ± 0.3 to 49.6 ± 1.8 μg kg<sup>–1</sup>. These values are below the MRL established by European Union regulation, which is 100 μg kg<sup>–1</sup>. <a href="javascript:void(0);">(42)</a> Although permethrin is not permitted in the European Union, <a href="javascript:void(0);">(42)</a> it remains authorized for use as insecticide in Brazil, particularly in crops such as cotton, rice, coffee, citrus, cabbage, beans, tobacco, maize, soybean, tomato, wheat, and grape. <a href="javascript:void(0);">(13)</a> However, no MRL values have been established for cocoa beans under Brazilian legislation. <a href="javascript:void(0);">(13)</a> <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsomega.5c10360#tbl3">Table 3</a> shows the concentration of detected compounds in the cocoa samples.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ACS_Omega_2025_10_51_63464_63473_Table_3_Mean_Concentrations_mg_kg_1_Standard_Deviation_of_Target_Pesticides_Detected_in_This_Study_2427955699.jpg" alt="ACS Omega 2025, 10, 51, 63464–63473: Table 3. Mean Concentrations (μg kg–1 ± Standard Deviation) of Target Pesticides Detected in This Study" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ACS_Omega_2025_10_51_63464_63473_Table_3_Mean_Concentrations_mg_kg_1_Standard_Deviation_of_Target_Pesticides_Detected_in_This_Study_2427955699.jpg 196w," sizes="100vw" width="1070" height="851"></p><p>To assess method performance for pesticides not detected in the cocoa samples, one of the analyzed samples was fortified with a mixed standard solution at concentrations of 50, 250, and 500 μg kg<sup>–1</sup>. The fortified analytes were subsequently detected in the chromatograms presented in <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/suppl/10.1021/acsomega.5c10360/suppl_file/ao5c10360_si_001.pdf">Figures S2–S4</a>, indicating good response of the proposed method.</p><h4><strong>Conclusions</strong></h4><p>The QuEChERS–LTP procedure was successfully developed for the determination of 16 multiclass pesticide residues in cocoa beans. For the first time, ultralow temperature (−80 °C) was applied to accelerate the low-temperature partitioning process during pesticide extraction from cocoa beans. Nevertheless, conventional freezing at −12 °C proved to be more effective for the extraction of the target analytes.</p><p>Evaluation of the matrix effect demonstrated that matrix-matched analytical curves, constructed in an analyte-free cocoa bean extract, were more effective in compensating for matrix interferences than the use of analyte protectants.</p><p>The pyrethroid permethrin was quantified in four cocoa samples. However, the concentrations did not exceed the MRL established by European Union legislation.</p><p>Overall, the QuEChERS–LTP procedure proved to be a promising approach for pesticide residue determination, as it requires smaller volumes of solvents and reagents, involves fewer cleanup and extraction steps, and shows strong potential for application to other complex matrices.</p>

QuEChERS Combined with Low-Temperature Partitioning and GC–MS as an Analytical Strategy for the Determination of Multiclass Pesticide Residues in Cocoa Beans

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

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The 100 position MULTIVAP parallel evaporator is a water bath model. This instrument contains a rectangular gas distribution system mounted on a frame and dual post assembly. 

<p><strong>The 100 position MULTIVAP parallel evaporator is a water bath model. This instrument contains a rectangular gas distribution system mounted on a frame and dual post assembly. The manifold delivers nitrogen gas to the needles or glass pipettes, which direct the gas onto the sample’s surface. This method results in rapid solvent evaporation and sample concentration. In order to conserve nitrogen gas, the manifold has a toggle switch for every row of 10 samples, which allows individual rows to be shut off when evaporating batches of less than 100 samples. Nitrogen gas flow is also controlled by an adjustable flow meter and a built-in pressure regulator.</strong></p><p>The 100 position MULTIVAP small vial evaporator uses a heated water bath to reach evaporative temperatures ranging <strong>from 30°C to 100°C</strong>. An unheated version is available for evaporations that will be performed at ambient temperatures. Sample racks are customized within a range of<strong> 11-22 mm</strong> for the user’s sample size. Please specify sample size (outside diameter and length to nearest 0.1 mm) when placing an order. All models can withstand contact with organic solvents; however acid resistant models are also available for use with corrosive solutions.</p><ul><li><strong>Capacity: </strong>Evaporate batches of up to 100 samples, with outside diameters of up to 22 mm</li><li><strong>Precise: </strong>Digital controls allow exact temperature regulation</li><li><strong>Optimum Heat Transfer: </strong>The water bath provides even heating and optimum heat transfer up to 100°C</li><li><strong>Consistent: </strong>Uniform evaporation across all samples with no adjustment needed between runs</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_100_Position_MULTIVAP_Nitrogen_Evaporator_2_e617ff2a8f.jpg" alt="Organomation 100 Position MULTIVAP Nitrogen Evaporator." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_100_Position_MULTIVAP_Nitrogen_Evaporator_2_e617ff2a8f.jpg 114w," sizes="100vw" width="1054" height="1440"></p><h3><strong>STANDARD FEATURES</strong></h3><ul><li>Adjustable flow meter, 0-50 lpm</li><li>Dual band hoist spring assembly</li><li>High temperature limit switch for safety</li><li>Safety control cover plate</li><li>Digital temperature controller</li><li>Electronic timer</li><li>Nitrogen filter</li><li>Gas distribution manifold</li><li>Built-in pressure reducing regulator</li><li>Needle guide</li></ul><h3><strong>OPTIONS&nbsp;</strong></h3><ul><li>220v wiring harness (Option Code# -2), Cat# 11300-2</li><li>Z-Purge/positive pressure purge case (Option Code# -Z), Cat# 11300-Z</li><li>Acid resistant coating on instrument and needles (Option Code# -RT), Cat# 11300-RT</li><li>Manifold and stand only: no heating platform (Option Code -O), Cat# 11300-O</li></ul><h3><strong>SPECS</strong></h3><h4><strong>100 Position MULTIVAP (Water Bath)</strong></h4><ul><li><strong>Heater Type</strong>: Water Bath</li><li><strong>Instrumental Catalog Number</strong>: 11300</li><li><strong>Number of Sample Positions</strong>: 100</li><li><strong>Overall Dimension (w × d × h)</strong>: 19 × 17 × 34 in / 48 × 43 × 86 cm</li><li><strong>Sample Holder Layout</strong>: Square</li><li><strong>Gas Manifold Layout</strong>: 10 × 10 Array</li><li><strong>Center to Center Spacing Between Positions</strong>: 1.0 in / 2.54 cm</li><li><strong>Test Tube Diameter</strong>: 11–22 mm OD</li><li><strong>Gas Flow Control On/Off Valve</strong>: Every row of 10</li><li><strong>Gas Flow Meter Range</strong>: 0–50 L/min</li><li><strong>Stainless Steel Needles (Length × Gauge)</strong>: 4.0 in × 19 ga / 102 mm × 19 ga</li><li><strong>Needle Guide</strong>: Standard</li><li><strong>Hoist Assembly</strong>: Dual Pulley &amp; Band Springs</li><li><strong>Built-in Gas Regulator Input</strong>: 30–110 psig</li><li><strong>Acid Resistant Coating (Option Code -RT)</strong>: Optional</li></ul><h5><strong>OA-SYS Heating Device Specifications</strong></h5><ul><li><strong>Model Number</strong>: 11196</li><li><strong>Inside Dimensions (Diameter × Depth)</strong>: 11 × 11 × 5.5 in / 28 × 28 × 14 cm</li><li><strong>Outside Dimensions (w × d × h)</strong>: 19 × 17 × 7 in / 48 × 43 × 18 cm</li><li><strong>Total Wattage</strong>: 1100 W</li><li><strong>Temperature Range</strong>: 30–100 °C</li><li><strong>Temperature Controller Type</strong>: Digital Electronic with LED Display</li><li><strong>Controller Accuracy</strong>: ±2 °C</li></ul><h4><strong>100 Position MULTIVAP (No Heater)</strong></h4><ul><li><strong>Heater Type</strong>: None</li><li><strong>Instrumental Catalog Number</strong>: 11300-O</li><li><strong>Number of Sample Positions</strong>: 100</li><li><strong>Overall Dimension (w × d × h)</strong>: 14 × 14 × 26 in / 35.5 × 35.5 × 66 cm</li><li><strong>Sample Holder Layout</strong>: Square</li><li><strong>Gas Manifold Layout</strong>: 10 × 10 Array</li><li><strong>Center to Center Spacing Between Positions</strong>: 1.0 in / 2.54 cm</li><li><strong>Test Tube Diameter</strong>: 11–22 mm OD</li><li><strong>Gas Flow Control On/Off Valve</strong>: Every row of 10</li><li><strong>Gas Flow Meter Range</strong>: 0–50 L/min</li><li><strong>Stainless Steel Needles (Length × Gauge)</strong>: 4.0 in × 19 ga / 102 mm × 19 ga</li><li><strong>Needle Guide</strong>: Standard</li><li><strong>Hoist Assembly</strong>: Dual Pulley &amp; Band Springs</li><li><strong>Built-in Gas Regulator Input</strong>: 30–110 psig</li><li><strong>Acid Resistant Coating (Option Code -RT)</strong>: Optional</li></ul><h3><strong>ACCESSORIES</strong></h3><ul><li>Custom sized racks (cat# NA1361)</li><li>Pasteur pipette adapters (cat# NA0636, cannot be used with needle guide)</li><li>Luer plugs (cat# NA1307)</li><li>Pressure reducing regulator 0-160 psi (cat# NA0630)</li><li>Various needle sizes and gauges</li></ul>

Organomation 15 Position MICROVAP Nitrogen Evaporator

The 15 position MICROVAP benchtop evaporator is intended for small batch solvent evaporations, such as concentrations of sample groups in microcentrifuge tubes.

<p><strong>The 15 position MICROVAP benchtop evaporator is intended for small batch solvent evaporations, such as concentrations of sample groups in microcentrifuge tubes. It offers an effective and compact evaporation solution for samples in life science and pharmaceutical laboratories.</strong></p><p>Each MICROVAP uses <strong>minimal hood space </strong>while providing optimal temperature control for high and low boiling point solvents. The 15 position MICROVAP comes standard with stainless steel luer lock hubs and<strong> 4-inch x 19-gauge stainless steel needles </strong>for easy removal.</p><p>Up to 15 samples can be accommodated at once, and the instrument comes customized for one sample size with an outside diameter of<strong> 10-22mm</strong>. If multiple sample sizes will be used with the instrument, inserts can be purchased for each additional sample size. &nbsp;</p><p>Each of the sample blocks and inserts are customized to your samples for a precise fit and optimum heat transfer.</p><p>Since these inserts and heat blocks are<strong> made-to-order</strong>, we will request that you deliver us three sample vials for each unique vial size upon placing an order for a 15 Position MICROVAP parallel evaporator. In situations where shipping sample vials to Organomation is not possible, we need<strong> precise measurements of your sample vials</strong> to be taken <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=BwDBasjstbE"><strong>as illustrated in this guide</strong></a><strong>.</strong></p><p>The digital temperature controls and solid aluminum heating unit provide uniform heat from room temperature up to <strong>130°C with temperature accuracy of +/- 2°C</strong>. The newly redesigned heating unit allows excellent heat stability for low temperature applications. A version without heat is available for evaporations that will be performed at ambient temperature.</p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/products/nitrogen-evaporators/microvap-classic/15-position-classic?hsLang=en"><strong>Discover our discontinued 15 Position MICROVAP model here for a discount. </strong></a><strong>Available while supplies last.</strong></p></blockquote><ul><li><strong>Compact Design: </strong>The MICROVAP has the smallest footprint of all of Organomation’s nitrogen evaporators</li><li><strong>Ease of Use: </strong>Temperature and gas levels are easily set using the digital temperature controller and gas flow meter</li><li><strong>Optimal Heat Transfer:</strong> Expertly machined heat block provides efficient heat transfer to sample tubes</li><li><strong>Versatility:</strong> Easily concentrate 96 well microplates using a conversion kit</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_15_Position_MICROVAP_Nitrogen_Evaporator_2_af9f41666c.jpg" alt="Organomation 15 Position MICROVAP Nitrogen Evaporator." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_15_Position_MICROVAP_Nitrogen_Evaporator_2_af9f41666c.jpg 158w," sizes="100vw" width="2984" height="2953"></p><h3><strong>STANDARD FEATURES</strong></h3><ul><li>Adjustable flow meter</li><li>Digital temperature control</li><li>High temperature limit switch</li><li>4-inch x 19-gauge needles &nbsp;</li><li>Nitrogen filter</li><li>Anodized aluminum heat block&nbsp;</li></ul><h3><strong>OPTIONS&nbsp;</strong></h3><ul><li>230V wiring harness (Option Code -2), Cat# 11815-2</li><li>Z-Purge/positive pressure purge case (Option Code -Z), Cat# 11815-Z</li><li>Manifold and stand only; no heating platform (Option Code -O), Cat# 11815-O</li><li>Acid resistant coating on instrument and needles (Option Code -RT), Cat# 11815-RT</li></ul><h3><strong>SPECS</strong></h3><h4><strong>15 Position MICROVAP (Dry Block)</strong></h4><ul><li><strong>Heater Type</strong>: Dry Block</li><li><strong>Instrument Catalog Number</strong>: 11815</li><li><strong>Number of Sample Positions</strong>: 15</li><li><strong>Overall Dimensions (w × d × h)</strong>: 10.0 × 13.0 × 18.0 in / 25.4 × 33.0 × 45.7 cm</li><li><strong>Sample Holder Layout</strong>: Rectangular</li><li><strong>Gas Manifold Layout</strong>: 3 × 5 Array</li><li><strong>Center to Center Spacing Between Positions</strong>: 1.0 in / 2.54 cm</li><li><strong>Heat Block Dimensions (w × d)</strong>: 3.5 × 5.125 in / 8.9 × 13 cm</li><li><strong>Test Tube Diameter</strong>: 10–22 mm OD</li><li><strong>Gas Flow Control</strong>: Single toggle valve</li><li><strong>Gas Flow Meter Range</strong>: 0–25 L/min</li><li><strong>Stainless Steel Needles (Length × Gauge)</strong>: 4.0 in × 19 ga / 102 mm × 19 ga</li><li><strong>Hoist Assembly</strong>: Manual</li><li><strong>Standard Gas Input Range</strong>: 20–30 psig</li><li><strong>Gas Input Range with Optional Pressure Reducing Regulator</strong>: 30–160 psig</li></ul><h5><strong>Heating Device Specs</strong></h5><ul><li><strong>Model Number</strong>: 1813A</li><li><strong>Outside Dimensions (w × d × h)</strong>: 10.0 × 9.75 × 3.5 in / 25.4 × 24.765 × 7.6 cm</li><li><strong>Total Wattage</strong>: 180 W</li><li><strong>Temperature Range</strong>: Room temp – 130 °C</li><li><strong>Temperature Controller Type</strong>: Digital Electronic with LED Display</li><li><strong>Controller Accuracy</strong>: ±2 °C</li></ul><h4><strong>15 Position MICROVAP (No Heater)</strong></h4><ul><li><strong>Heater Type</strong>: None</li><li><strong>Instrument Catalog Number</strong>: 11815-O</li><li><strong>Number of Sample Positions</strong>: 15</li><li><strong>Overall Dimensions (w × d × h)</strong>: 10.5 × 12.5 × 15 in / 26.7 × 31.8 × 38.1 cm</li><li><strong>Sample Holder Layout</strong>: Rectangular</li><li><strong>Gas Manifold Layout</strong>: 3 × 5 Array</li><li><strong>Center to Center Spacing Between Positions</strong>: 1.0 in / 2.54 cm</li><li><strong>Heat Block Dimensions (w × d)</strong>: 3.5 × 5.125 in / 8.9 × 13 cm</li><li><strong>Test Tube Diameter</strong>: 10–22 mm OD</li><li><strong>Gas Flow Control</strong>: Single toggle valve</li><li><strong>Gas Flow Meter Range</strong>: 0–25 L/min</li><li><strong>Stainless Steel Needles (Length × Gauge)</strong>: 4.0 in × 19 ga / 102 mm × 19 ga</li><li><strong>Hoist Assembly</strong>: Manual</li><li><strong>Standard Gas Input Range</strong>: 20–30 psig</li><li><strong>Gas Input Range with Optional Pressure Reducing Regulator</strong>: 30–160 psig</li></ul><h3><strong>ACCESSORIES</strong></h3><ul><li>Nitrogen generator (cat# NA1955)</li><li>Pressure reducing regulator, 30-160 psi in, 0-30 psi out</li><li>Pasteur pipette adapters (cat# NA0636)</li><li>15 position conversion kit</li><li>96 well plate conversion kit</li><li>Various needles sizes and gauges</li></ul>

Organomation 24 Position MICROVAP Nitrogen Evaporator

The 24 position MICROVAP small vial evaporator is intended for concentrating small volume, small batch samples, such as concentrations of groups of samples in microcentrifuge tubes and GC vials.

<p><strong>The 24 position MICROVAP small vial evaporator is intended for concentrating small volume, small batch samples, such as concentrations of groups of samples in microcentrifuge tubes and GC vials. It offers an effective and compact solution to evaporation of samples for life sciences and pharmaceutical laboratories.&nbsp;</strong></p><p>Each MICROVAP uses <strong>minimal hood space while </strong>providing optimal temperature control for high and low boiling point solvents. The 24 position MICROVAP comes standard with stainless steel luer lock hubs and <strong>4-inch x 19-gauge stainless steel needles </strong>for easy removal.&nbsp;</p><p>Up to 24 samples can be accommodated at once, and the instrument comes customized for one sample size with an outside diameter of <strong>10 -17 mm</strong>. If multiple sample sizes will be used with the instrument, additional sample blocks can be purchased for each additional sample size. . &nbsp;</p><p>Each of the sample blocks and inserts are customized to your samples for a precise fit and optimum heat transfer. Since these inserts and heat blocks are<strong> made-to-order</strong>, we will request that you deliver us three sample vials for each unique vial size upon placing an order for a 24 Position MICROVAP parallel evaporator. In situations where shipping sample vials to Organomation is not possible, we need<strong> precise measurements of your sample vials</strong> to be taken <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=BwDBasjstbE"><strong>as illustrated in this guide</strong></a><strong>.</strong></p><p>The digital temperature controls and solid aluminum heating unit provide uniform heat from room temperature up to <strong>130°C with temperature accuracy of +/- 2°C</strong>. The newly redesigned heating unit allows excellent heat stability for low temperature applications. A version without heat is available for evaporations that will be performed at ambient temperature.</p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/products/nitrogen-evaporators/microvap-classic/24-position-classic?hsLang=en"><span style="color:#0600ff;"><strong>Discover our discontinued 24 Position MICROVAP model here for a discount.</strong></span></a><a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/products/nitrogen-evaporators/microvap-classic/15-position-classic?hsLang=en"><strong> </strong></a><strong>Available while supplies last.</strong></p></blockquote><ul><li><strong>Compact Design: </strong>The MICROVAP has the smallest footprint of all of Organomation’s nitrogen evaporators</li><li><strong>Ease of Use: </strong>Temperature and gas levels are easily set using the digital temperature controller and gas flow meter</li><li><strong>Optimal Heat Transfer:</strong> Expertly machined heat block provides efficient heat transfer to sample tubes</li><li><strong>Versatility:</strong> Easily concentrate 96 well microplates using a conversion kit</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_24_Position_MICROVAP_Nitrogen_Evaporator_2_1601383cd9.jpg" alt="Organomation 24 Position MICROVAP Nitrogen Evaporator." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_24_Position_MICROVAP_Nitrogen_Evaporator_2_1601383cd9.jpg 152w," sizes="100vw" width="3024" height="3102"></p><h3><strong>STANDARD FEATURES</strong></h3><ul><li>Adjustable flow meter</li><li>Digital temperature control</li><li>High temperature limit switch</li><li>4-inch x 19 gauge needles</li><li>Nitrogen filter</li><li>Anodized aluminum dry block</li></ul><h3><strong>OPTIONS&nbsp;</strong></h3><ul><li>230V wiring harness (Option Code -2), Cat# 11824-2</li><li>Z-Purge/positive pressure purge case (Option Code -Z), Cat# 11824-Z</li><li>Manifold and stand only: no heating platform (Option Code -O), Cat# 11824-O</li><li>Acid resistant coating on instrument and needles (Option Code -RT), Cat# 11824-RT<br>&nbsp;</li></ul><h3><strong>SPECS</strong></h3><h4><strong>24 Position MICROVAP (Dry Block)</strong></h4><ul><li><strong>Heater Type</strong>: Dry Block</li><li><strong>Instrument Catalog Number</strong>: 11824</li><li><strong>Number of Sample Positions</strong>: 24</li><li><strong>Overall Dimension (w × d × h)</strong>: 10.0 × 13.0 × 18.0 in / 25.4 × 33.0 × 45.7 cm</li><li><strong>Sample Holder Layout</strong>: Rectangular</li><li><strong>Gas Manifold Layout</strong>: 4 × 6 Array</li><li><strong>Center to Center Spacing Between Positions</strong>: 0.78 in / 1.98 cm</li><li><strong>Test Tube Diameter</strong>: 10–17 mm OD</li><li><strong>Gas Flow Control</strong>: Single toggle valve</li><li><strong>Gas Flow Meter Range</strong>: 0–25 L/min</li><li><strong>Stainless Steel Needles (Length × Gauge)</strong>: 4.0 in × 19 ga / 102 mm × 19 ga</li><li><strong>Hoist Assembly</strong>: Manual</li><li><strong>Standard Gas Input Range</strong>: 20–30 psig</li><li><strong>Gas Input Range with Optional Pressure Reducing Regulator</strong>: 30–160 psig</li></ul><h5><strong>Heating Device Specs</strong></h5><ul><li><strong>Model Number</strong>: 1813A</li><li><strong>Outside Dimensions (w × d × h)</strong>: 10.0 × 9.75 × 3.5 in / 25.4 × 24.765 × 7.6 cm</li><li><strong>Total Wattage</strong>: 180 W</li><li><strong>Temperature Range</strong>: Room temp – 130 °C</li><li><strong>Temperature Controller Type</strong>: Digital Electronic with LED Display</li><li><strong>Controller Accuracy</strong>: ±2 °C</li></ul><h4><strong>24 Position MICROVAP (No Heater)</strong></h4><ul><li><strong>Heater Type</strong>: None</li><li><strong>Instrument Catalog Number</strong>: 11824-O</li><li><strong>Number of Sample Positions</strong>: 24</li><li><strong>Overall Dimension (w × d × h)</strong>: 10.5 × 12.5 × 15.0 in / 21.6 × 33.0 × 35.6 cm</li><li><strong>Sample Holder Layout</strong>: Rectangular</li><li><strong>Gas Manifold Layout</strong>: 4 × 6 Array</li><li><strong>Center to Center Spacing Between Positions</strong>: 0.78 in / 1.98 cm</li><li><strong>Test Tube Diameter</strong>: 10–17 mm OD</li><li><strong>Gas Flow Control</strong>: Single toggle valve</li><li><strong>Gas Flow Meter Range</strong>: 0–25 L/min</li><li><strong>Stainless Steel Needles (Length × Gauge)</strong>: 4.0 in × 19 ga / 102 mm × 19 ga</li><li><strong>Hoist Assembly</strong>: Manual</li><li><strong>Standard Gas Input Range</strong>: 20–30 psig</li><li><strong>Gas Input Range with Optional Pressure Reducing Regulator</strong>: 30–160 psig</li></ul><h3><strong>ACCESSORIES</strong></h3><ul><li>Nitrogen generator (cat# NA1955)</li><li>Pressure reducing regulator, 30-160 psi in, 0-30 psi out</li><li>Pasteur pipette adapters (cat# NA0636)</li><li>15 position conversion kit</li><li>96 well plate conversion kit</li><li>Various needles sizes and gauges</li></ul>

Organomation MICROVAP Microplate Evaporator

The single plate MICROVAP microplate evaporator is one of the most compact sample concentrators available, and it continues to meet the needs of the life science and pharmaceutical industries.

<p><strong>The single plate MICROVAP microplate evaporator is one of the most compact sample concentrators available, and it continues to meet the needs of the life science and pharmaceutical industries. This microplate concentrator is ideal for laboratories needing efficient solutions for the gentle evaporation of high capacity, low volume samples in 96-well microplates and 96-well deep plates. The gas delivery manifold offers continuous evaporation via 2-inch x 19-gauge stainless steel needles.</strong></p><p>In order to evaporate solvents with a wide range of boiling points effectively, the digital temperature controls and solid aluminum heating unit provide uniform heat from room temperature up to <strong>130°C with temperature accuracy of +/- 2°C</strong>. The newly redesigned heating unit allows excellent heat stability for low temperature applications. A version without heat is available for evaporations that will be performed at ambient temperatures.&nbsp;</p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/products/nitrogen-evaporators/microvap-classic/microplate-evaporator-classic?hsLang=en"><span style="color:#0600ff;"><strong>Discover our discontinued Single Plate MICROVAP model here for a discount.</strong></span></a><span style="color:#0600ff;"> </span>Available while supplies last.</p></blockquote><ul><li><strong>Compact Design: </strong>The MICROVAP has the smallest footprint of all of Organomation’s nitrogen evaporators</li><li><strong>Ease of Use: </strong>Temperature and gas levels are easily set using the digital temperature controller and gas flow meter</li><li><strong>Precise: </strong>Digital controls allow exact temperature regulation</li><li><strong>Versatility:</strong> Easily concentrate 15 or 24 tube samples using a conversion kit</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_MICROVAP_Microplate_Evaporator_2_6fec84ea62.jpg" alt="Organomation MICROVAP Microplate Evaporator." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_MICROVAP_Microplate_Evaporator_2_6fec84ea62.jpg 144w," sizes="100vw" width="3024" height="3286"></p><h3><strong>STANDARD FEATURES</strong></h3><ul><li>Adjustable flow meter</li><li>Digital temperature control</li><li>High temperature limit switch</li><li>2-inch x 19-gauge needles</li><li>Nitrogen filter</li><li>Anodized aluminum dry block</li></ul><h3><strong>OPTIONS&nbsp;</strong></h3><ul><li>230v wiring harness (Option Code -2), Cat# 11801-2</li><li>Z-Purge/positive pressure purge case (Option Code -Z), Cat# 11801-Z</li><li>Manifold and stand only; no heating platform (Option Code -O), Cat# 11801-O</li><li>Acid resistant coating on instrument and needles (Option Code -RT), Cat# 11801-RT</li></ul><h3><strong>SPECS</strong></h3><h4><strong>Single Plate MICROVAP (Dry Block)</strong></h4><ul><li><strong>Heater Type</strong>: Dry Block</li><li><strong>Instrumental Catalog Number</strong>: 11801</li><li><strong>Number of Sample Positions</strong>: 1</li><li><strong>Overall Dimension (w × d × h)</strong>: 10.0 × 13.0 × 18.0 in / 25.4 × 33.0 × 45.7 cm</li><li><strong>Gas Manifold Layout</strong>: 8 × 12 Array</li><li><strong>Center to Center Spacing Between Positions</strong>: 0.354 in / 9.0 mm</li><li><strong>Microplate Dimensions (w × d)</strong>: 3.375 × 5.0 in / 8.5 × 13 cm</li><li><strong>Gas Flow Control</strong>: Single toggle valve</li><li><strong>Gas Flow Meter Range</strong>: 0–25 L/min</li><li><strong>Stainless Steel Needles (Length × Gauge)</strong>: 2.0 in × 19 ga / 51 mm × 19 ga</li><li><strong>Hoist Assembly</strong>: Manual</li><li><strong>Standard Gas Input Range</strong>: 20–30 psig</li><li><strong>Gas Input Range with Optional Pressure Reducing Regulator</strong>: 30–160 psig</li></ul><h5><strong>Heating Device Specs</strong></h5><ul><li><strong>Model Number</strong>: 1813A</li><li><strong>Outside Dimensions (w × d × h)</strong>: 10.0 × 8.375 × 3.5 in / 25.4 × 21.3 × 7.6 cm</li><li><strong>Total Wattage</strong>: 180 W</li><li><strong>Temperature Range</strong>: Room temp – 130 °C</li><li><strong>Temperature Controller Type</strong>: Digital Electronic with LED Display</li><li><strong>Controller Accuracy</strong>: ±2 °C</li></ul><h4><strong>Single Plate MICROVAP (No Heater)</strong></h4><ul><li><strong>Heater Type</strong>: None</li><li><strong>Instrumental Catalog Number</strong>: 11801-O</li><li><strong>Number of Sample Positions</strong>: 1</li><li><strong>Overall Dimension (w × d × h)</strong>: 10.5 × 12.5 × 15.0 in / 26.7 × 31.8 × 38.1 cm</li><li><strong>Gas Manifold Layout</strong>: 8 × 12 Array</li><li><strong>Center to Center Spacing Between Positions</strong>: 0.354 in / 9.0 mm</li><li><strong>Microplate Dimensions (w × d)</strong>: 3.375 × 5.0 in / 8.5 × 13 cm</li><li><strong>Gas Flow Control</strong>: Single toggle valve</li><li><strong>Gas Flow Meter Range</strong>: 0–25 L/min</li><li><strong>Stainless Steel Needles (Length × Gauge)</strong>: 2.0 in × 19 ga / 51 mm × 19 ga</li><li><strong>Hoist Assembly</strong>: Manual</li><li><strong>Standard Gas Input Range</strong>: 20–30 psig</li><li><strong>Gas Input Range with Optional Pressure Reducing Regulator</strong>: 30–160 psig</li></ul><h3><strong>ACCESSORIES</strong></h3><ul><li>Pressure reducing regulator, 30-160 psi in, 0-30 psi out</li><li>Pasteur pipette adapters (cat# NA0636)</li><li>15 position conversion kit</li><li>96 well plate conversion kit</li><li>Various needles sizes and gauges</li></ul>

Organomation MICROVAP Triple Microplate Evaporator

The triple plate MICROVAP microplate evaporator combines three 96 needle manifolds and three heat blocks into a single platform.

<p><strong>The triple plate MICROVAP microplate evaporator combines three 96 needle manifolds and three heat blocks into a single platform. This allows for simultaneous evaporation of up to three 96 well plates. The triple plate MICROVAP’s solid aluminum heating units provide consistent temperature for uniform evaporation rates throughout all three plates.</strong></p><p>Each 96-needle manifold is equipped with its own toggle switch to shut down gas flow when all three microplates are not in use to conserve nitrogen gas, saving laboratories money. A convenient dual band spring hoist assembly ensures ease of use for the operator when lowering and raising the needle manifolds. The digital temperature controller is easy to read and allows temperature to be controlled with an accuracy of <strong>+/- 2 °C up to the maximum temperature of 130°C</strong>. &nbsp;An adjustable <strong>0-100 LPM flow meter</strong> is for precise control over the nitrogen gas delivery system.&nbsp;</p><ul><li><strong>High Throughput: </strong>Evaporate up to three 96 well plates at once</li><li><strong>Ease of Use: </strong>Temperature and gas levels are easily set using the digital temperature controller and gas flow meter</li><li><strong>Precise: </strong>Digital controls allow exact temperature regulation</li><li><strong>Cost-Effective: </strong>Conserve nitrogen by turning gas flow on and off at each plate</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_MICROVAP_Triple_Microplate_Evaporator_2_d67a3e5ffd.jpg" alt="Organomation MICROVAP Triple Microplate Evaporator." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_MICROVAP_Triple_Microplate_Evaporator_2_d67a3e5ffd.jpg 156w," sizes="100vw" width="1400" height="1400"></p><h3><strong>STANDARD FEATURES</strong></h3><ul><li>Adjustable flow meter</li><li>Digital temperature control</li><li>High temperature limit switch</li><li>High pressure tubing</li><li>2-inch x 19-gauge needles</li><li>Nitrogen filter</li><li>Anodized aluminum dry block&nbsp;</li></ul><h3><strong>OPTIONS&nbsp;</strong></h3><ul><li>220v wiring harness (Option Code -2), Cat# 11803-2</li><li>Z-Purge/positive pressure purge case (Option Code -Z), Cat# 11803-Z</li><li>Acid resistant coating on instrument and needles (Option Code -RT), Cat# 11803-RT</li></ul><h3><strong>SPECS</strong></h3><h4><strong>12p N-EVAP (Dry Block)</strong></h4><ul><li><strong>Heater Type</strong>: Dry Block</li><li><strong>Instrument Catalog Number</strong>: 11803</li><li><strong>Number of Sample Plates</strong>: 3</li><li><strong>Overall Dimension (w × d × h)</strong>: 21.0 × 13.0 × 13.0 in / 53.3 × 33.02 × 33.02 cm</li><li><strong>Gas Manifold Layout</strong>: Triple 8 × 12 Array</li><li><strong>Center to Center Spacing Between Positions</strong>: 0.354 in / 9.0 mm</li><li><strong>Microplate Dimensions (w × d)</strong>: 3.375 × 5.0 in / 8.5 × 13 cm</li><li><strong>Gas Flow Control</strong>: Single toggle valve</li><li><strong>Gas Flow Meter Range</strong>: 0–100 L/min</li><li><strong>Stainless Steel Needles (Length × Gauge)</strong>: 2.0 in × 19 ga / 51 mm × 19 ga</li><li><strong>Hoist Assembly</strong>: Dual Band Spring Hoist Assembly</li><li><strong>Standard Gas Input Range</strong>: 30 psig</li><li><strong>Gas Input Range with Optional Pressure Reducing Regulator</strong>: 30–160 psig</li></ul><h5><strong>Heating Device Specs</strong></h5><ul><li><strong>Model Number</strong>: 54243</li><li><strong>Outside Dimensions (w × d × h)</strong>: 24.0 × 9.5 × 3.0 in / 61.0 × 22.9 × 7.6 cm</li><li><strong>Total Wattage</strong>: 540 W</li><li><strong>Temperature Range</strong>: 40–130 °C</li><li><strong>Temperature Controller Type</strong>: Digital Electronic with LED Display</li><li><strong>Controller Accuracy</strong>: ±2 °C</li></ul><h3><strong>ACCESSORIES</strong></h3><ul><li>Pressure reducing regulator, 30-150 psi in, 0-30 psi out</li></ul>

Waters Andrew+ pipetting robot

Andrew+ pipetting robot offers fully automated liquid handling using electronic pipettes and labware holders called Dominos.

<div data-id="7b8f701" data-element_type="widget" data-widget_type="heading.default"><div><h3><strong>Discover lab automation within reach</strong></h3></div></div><div data-id="c1b56fb" data-element_type="widget" data-widget_type="text-editor.default"><div><p><strong>Andrew+ pipetting robot offers fully automated liquid handling using electronic pipettes and labware holders called Dominos. By adding Device+, our ever-expanding portfolio of connected devices and tools for processes such as heating, shaking or labware transportation, Andrew+ evolves into a full walk-away automation solution.</strong></p><p>Creating the connected laboratory, Andrew+ is part of the&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.andrewalliance.com/laboratory-software/"><strong>OneLab</strong></a>&nbsp;ecosystem, executing laboratory protocols designed in OneLab.&nbsp; This flexible architecture enables you to effortlessly transition from laborious manual pipetting procedures to error-free, fully-robotized lab workflows – without any knowledge of programming, laboratory robotics or automation engineering.</p><blockquote><p class="cke-user_style-important"><strong>Video: </strong><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=IGu3YxkkZY0"><strong>Andrew+ Demo</strong></a></p></blockquote><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Andrew_pipetting_robot_4_0569f8609e.jpg" alt="Waters Andrew+ pipetting robot" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Andrew_pipetting_robot_4_0569f8609e.jpg 245w," sizes="100vw" width="1440" height="540"></p><h3><strong>Andrew+ Case Studies&nbsp;</strong></h3><blockquote><p class="cke-user_style-important"><a target="_blank" rel="noopener noreferrer" href="https://www.andrewalliance.com/category/case-studies/"><span>See all case studies</span>&nbsp;</a></p></blockquote><div data-id="ee37b9e" data-element_type="widget" data-widget_type="heading.default"><div><h3><strong>Watch Andrew+ in action</strong></h3></div></div><div data-id="b265a33" data-element_type="widget" data-widget_type="text-editor.default"><div><p>In these videos, our biologists explain how Andrew+ enables users to automate commonly used, laborious, liquid handling for PCR Prep and Plasmid DNA Purification, respectively, whilst ensuring superior repeatability and full traceability.</p><blockquote><p class="cke-user_style-important"><strong>Video: </strong><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=RnxDri3Z7f4"><strong>PCR Prep</strong></a></p><p class="cke-user_style-important"><strong>Video: </strong><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=oWOkzqF9X9I"><strong>Plasmid DNA Prep</strong></a></p></blockquote><div data-id="fc9cb9e" data-element_type="column"><div><div data-id="cbb1a9b" data-element_type="widget" data-widget_type="heading.default"><div><h3><strong>Intuitive user interface</strong></h3></div></div><div data-id="3799119" data-element_type="widget" data-widget_type="text-editor.default"><div><div><div><div><div><div><p>Reproducibility and full traceability of sample preparation is assured using a highly intuitive browser-based software environment.&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.andrewalliance.com/laboratory-software/"><strong>OneLab</strong></a> enables scientists to graphically design their own pipetting protocols in minutes and execute them straight away in any laboratory in the world, even allowing the remote monitoring of ongoing experiments. Use a flexible and secure platform that withstands the rigors of regulatory validation.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Onelab_design_2_489d32ac68/Waters-Onelab-design-2_l.webp" alt="Waters-Onelab-design-2_l.webp" width="1027" height="488"></p><div data-id="9199ea6" data-element_type="column"><div><div data-id="6db85f8" data-element_type="widget" data-widget_type="heading.default"><div><h3><strong>Widest pipetting volume range</strong></h3></div></div><div data-id="ae0caea" data-element_type="widget" data-widget_type="text-editor.default"><div><p>Andrew+ pipetting robot uses single and multichannel electronic pipettes, ensuring the best liquid handling performance and maximum flexibility. Smart electronic pipettes are manufactured by Sartorius and based upon their acclaimed Picus pipettes.</p><p>Electronic pipettes are optimized for used with the Andrew+ pipetting robot, allowing greater flexibility in the type of liquid handling experiments that can be run, providing superior experiment reproducibility, pipetting speed and a market leading dynamic range of dispensing volumes for a liquid handing robot –from 0.2 µL up to 10 mL.</p><figure class="image"><img style="aspect-ratio:529/382;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Andrew_pipetting_robot_f5ca4f825d.jpg" alt="Waters Andrew+ pipetting robot.jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Andrew_pipetting_robot_f5ca4f825d.jpg 216w," sizes="100vw" width="529" height="382"></figure><div data-id="ed235f6" data-element_type="column"><div><div data-id="ef6b933" data-element_type="widget" data-widget_type="heading.default"><div><h3><strong>Andrew+ is compact</strong></h3></div></div><div data-id="7537e2e" data-element_type="widget" data-widget_type="text-editor.default"><div><div><div><div><div><div><p>The liquid handling robot is designed to fit the majority of laboratory benches and biosafety cabinets (BSC). Andrew+, even with 2 full rows of Dominos&nbsp;<i>(</i>allowing to use 7 microplates or 56 falcon tubes or 168 microtubes) occupies a depth of ~55cm/22”, that fits even the smallest hoods. The unique compact size and design of our liquid handler allows it to work at a temperature of 20°C-37°C.&nbsp;</p><figure class="image"><img style="aspect-ratio:836/556;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Andrew_pipetting_robot_2_fb174b1453.jpg" alt="Waters Andrew+ pipetting robot - 2.jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Andrew_pipetting_robot_2_fb174b1453.jpg 235w," sizes="100vw" width="836" height="556"></figure><div data-id="c9b37a7" data-element_type="widget" data-widget_type="heading.default"><div><h3><strong>Versatile working deck, tools and devices for all your needs</strong></h3></div></div><section data-id="b802f90" data-element_type="section" data-settings="{&quot;jet_parallax_layout_list&quot;:[]}"><div><div data-id="3e689f0" data-element_type="column"><div><div data-id="5dc9372" data-element_type="widget" data-widget_type="text-editor.default"><div><p>The Andrew+ deck layout is quickly adaptable to your experiment materials and are incredibly easy to set with the ever-expanding range of Dominos: a magnetic-based modular solution that enables Andrew+ to use a broad range of consumables.</p></div></div></div></div><div data-id="5626074" data-element_type="column"><div><div data-id="40c6ef1" data-element_type="widget" data-widget_type="text-editor.default"><div><p>In addition to pipetting liquids, the Andrew+ liquid handler can perform a wide range of complex experimental steps such as tube/plate transport or solid-phase extraction using vacuum.<br>Thanks to OneLab, you will benefit to a seamless integration of new capabilities added to your setting.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Andrew_pipetting_robot_3_89b87a0d2e.jpg" alt="Waters Andrew+ pipetting robot - 3.jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Andrew_pipetting_robot_3_89b87a0d2e.jpg 245w," sizes="100vw" width="1734" height="598"></p><div data-id="d090821" data-element_type="column"><div><div data-id="f9d733b" data-element_type="widget" data-widget_type="heading.default"><div><h3><strong>Automated Protocols with Andrew+</strong></h3><p>Specifically optimized for Andrew+, various applications and methods guarantee the delivery of better pipetting accuracy and improved reproducibility.</p><blockquote><ul><li><div><a target="_blank" rel="noopener noreferrer" href="https://onelab.andrewalliance.com/library/sars-cov-2-lc-ms-kit-ruo-9lwrvwkA"><span>Automated preparation of SARS-CoV-2 peptides for LC-MS analysis</span></a></div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://onelab.andrewalliance.com/library/automated-antibody-purification-jlwKQ0aY"><span>Automated Antibody Purification for higher recovery and reproducibility</span></a></div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://onelab.andrewalliance.com/app/lab/bl6MQP6z/library/standard-curve-generation-KlwRbwR3"><span>Reliable and Robust Sample Prep for Standard Curve Generation</span></a></div></li></ul><p class="cke-user_style-important"><a target="_blank" rel="noopener noreferrer" href="https://onelab.andrewalliance.com/library"><span><strong>More to discover in the Protocol Library</strong></span></a></p></blockquote><h3><strong>Get an extra pair of hands</strong></h3><div data-id="aa4715f" data-element_type="widget" data-widget_type="heading.default"><div><h4><strong>Reproducibility</strong></h4></div></div><div data-id="a1d2f3b" data-element_type="widget" data-widget_type="text-editor.default"><div><div><div data-animationtype="fadeInDown" data-animationduration="0.7" data-animationoffset="top-into-view"><div><p>Laboratory automation eliminates most human errors resulting in more reliable data and improved productivity. Together with complete integration inside OneLab, all experimental data from Andrew+ will be recorded and stored, improving the traceability of experiments and the data analysis.</p><div data-id="fb36639" data-element_type="widget" data-widget_type="heading.default"><div><h4><strong>Productivity</strong></h4></div></div><div data-id="c5f6abd" data-element_type="widget" data-widget_type="text-editor.default"><div><div><div data-animationtype="fadeInDown" data-animationduration="0.7" data-animationoffset="top-into-view"><div><div><div data-animationtype="fadeInDown" data-animationduration="0.7" data-animationoffset="top-into-view"><div><p>Andrew+ combines the flexibility of single channel pipetting (0.2 μL to 10 mL) with the higher throughput of multichannel pipetting. In addition, Andrew+ reduces the need to repeat experiments due to pipetting errors.</p><div data-id="0a035d7" data-element_type="widget" data-widget_type="heading.default"><div><h4><strong>Promoting health</strong></h4></div></div><div data-id="a72e364" data-element_type="widget" data-widget_type="text-editor.default"><div><div><div data-animationtype="fadeInDown" data-animationduration="0.7" data-animationoffset="top-into-view"><div><div id="applications"><div><div><div><div><div id="icon-area" data-animationoffset="top-into-view"><div><div data-animationtype="fadeInDown" data-animationduration="0.7" data-animationoffset="top-into-view"><div><p>Pipetting requires repetitive movements (of up to 500 times per day for the average user) that can lead to musculo-skeletal disorders like repetitive strain injury. Andrew+ helps eliminates physical stress to professionals, and also reduces the risk of exposure to hazardous materials used in certain experimental procedures.</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></section></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

EST Analytical LGX-50 for Methane in Water

The EST LGX-50 automates RSK-175 dissolved gas testing in water, boosting throughput, ensuring ASTM/EPA compliance, and reducing manual sample preparation errors.

<p><strong>The LGX-50 automates the preparation of water samples for headspace analysis of dissolved gases such as methane, ethane, and ethene. Traditionally, RSK-175 testing has been labor-intensive and time-consuming, requiring manual vial preparation. The LGX-50 eliminates this step, streamlining workflows and ensuring compliance with EPA Method 5035 and ASTM D8028. By automating dissolved gas extraction, laboratories can boost throughput, reduce errors, and deliver more consistent results for shale gas and environmental testing.</strong></p><h4><strong>Key Features</strong></h4><h5><strong>Maximized Productivity</strong></h5><ul><li>Fully automates <strong>RSK-175 sample processing</strong></li><li>ASTM D8028 compliant for dissolved gas testing</li><li>Holds up to <strong>50 samples</strong> for high-throughput operation</li><li>Optical sensors prevent vial misplacement and syringe/elevator errors</li><li>Robust XYZ design ensures reliability and consistent performance</li></ul><h5><strong>Simplified Operation</strong></h5><ul><li>Intuitive, user-friendly software designed for quick setup and operation</li><li>Remote access functionality allows labs to monitor sample progress via the server</li><li>Reduces manual preparation steps, increasing accuracy and reproducibility</li></ul><h4><strong>Technical Specifications</strong></h4><ul><li><strong>Compliance</strong>: EPA Method 5035, ASTM D8028</li><li><strong>Capacity</strong>: Up to 50 samples per batch</li><li><strong>Target Compounds</strong>: Methane, ethane, ethene, and other dissolved gases in water</li><li><strong>Automation</strong>: XYZ robotic design with optical sensors for error prevention</li><li><strong>Software</strong>: Intuitive, remote-access capable interface</li></ul>

Thermo Scientific Dionex AutoTrace 280 Solid-Phase Extraction Instrument

Extract analytes of interest from large volume aqueous samples easily and efficiently with the Thermo Scientific™ Dionex™ AutoTrace™ 280 Solid-Phase Extraction (SPE) Instrument.

<p><strong>Extract analytes of interest from large volume aqueous samples easily and efficiently with the Thermo Scientific™ Dionex™ AutoTrace™ 280 Solid-Phase Extraction (SPE) Instrument.&nbsp;</strong></p><p>The AutoTrace 280 automates all four steps of SPE (conditioning, loading, rinsing, and eluting), reducing solvent consumption and improving recovery and reproducibility. Boost productivity and reduce cost of analysis by simultaneously processing up to six samples in 2-3 hours with only 15 minutes of operator involvement. The AutoTrace 280 meets requirements in US EPA methods including the 500 and 600 series.</p><h5><strong>Improved reliability and recovery</strong></h5><ul><li>Automated SPE minimizes operator intervention</li><li>Positive pressure loading and elution of samples and solvents provide constant flow for improved analytical precision</li></ul><h5><strong>Flexibility in operation</strong></h5><ul><li>Loads sample volumes from 20 mL to 4 L</li><li>Compatible with 1, 3, and 6 mL cartridges and with 47 mm SPE disks</li><li>Automatically conditions, rinses, and elutes SPE cartridges with a choice of five solvents</li><li>Offers a choice of six different collection vial racks</li></ul><h5><strong>Improved laboratory safety</strong></h5><ul><li>Minimal sample handling reduces operator exposure to hazardous chemicals</li><li>No hood required</li></ul><h5><strong>Enhanced laboratory productivity and reduced costs</strong></h5><ul><li>Unattended operation</li><li>Batch processing of up to 6 samples</li><li>Reduced solvent usage</li><li>Segregates aqueous and solvent waste using separate waste lines for efficient, cost-effective waste handling</li></ul><h5><strong>Supports a range of matrices and applications</strong></h5><ul><li>Ability to process samples containing suspended solids</li><li>Meets requirements for solid-phase extraction for U.S. EPA methods including 500 and 600 series</li></ul><h5><strong>Recommended use</strong></h5><ul><li>Analyze prepared samples with Thermo Scientific LC or GC systems for a fully integrated workflow</li></ul><h4><strong>Specifications</strong></h4><ul><li><strong>Instrument Type:</strong> Automated Solid Phase Extraction (SPE) System</li><li><strong>Application:</strong> For use with 47 mm SPE disks</li><li><strong>Model Description:</strong> AutoTrace 280 SPE System</li></ul><h5><strong>Performance &amp; Operating Details</strong></h5><ul><li><strong>Disk Compatibility:</strong> Designed for 47 mm SPE disks</li><li><strong>Pressure Range:</strong><ul><li>Output: 0 to 30 psi (0 to 1.4 bar)</li><li>Input: Up to 100 psi (6.9 bar) maximum</li></ul></li><li><strong>Voltage:</strong> 100–240 V ±10%</li><li><strong>Frequency:</strong> 47–63 Hz</li></ul><h5><strong>Physical Specifications</strong></h5><ul><li><strong>Dimensions (D × W × H):</strong> 57 × 63.5 × 69 cm</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific EXTREVA ASE Accelerated Solvent Extractor

Achieve true walkaway sample-to-vial sample preparation with the Thermo Scientific™ EXTREVA™ ASE™ Accelerated Solvent Extractor. 

<p><strong>Achieve true walkaway sample-to-vial sample preparation with the Thermo Scientific™ EXTREVA™ ASE™ Accelerated Solvent Extractor. Without any intervention, perform sample extraction, in-cell cleanup and evaporation—all in one seamless operation—reducing manual labor from hours to minutes and enabling you to focus on other lab priorities while using up to 50% less solvent than other sample preparation techniques.</strong></p><p><strong>Accelerate your journey from sample to vial</strong></p><h5><strong>The EXTREVA ASE Accelerated Solvent Extractor offers:</strong></h5><ul><li><strong>All-in-one sample preparation.</strong> The EXTREVA ASE system automatically extracts and concentrates samples, eliminating the need to manually move sample extracts to another device for solvent evaporation.</li><li><strong>A walk-away solution. </strong>The system minimizes hands-on sample preparation tasks, enabling staff to accomplish other tasks.</li><li><strong>Parallel extraction. </strong>One EXTREVA ASE system can perform four parallel sample extractions, substantially increasing throughput.</li><li><strong>Gas-assisted extraction. </strong>The dynamic gas-assisted extraction mode reduces solvent consumption to between 5 and 100 milliliters per sample in most cases.</li><li><strong>Automation. </strong>Full automation improves recoveries and reproducibility while reducing training needs. Unlike humans, automated systems are ideal for performing the same tedious task repeatedly, and they don’t make mistakes.</li><li><strong>Method flexibility and optimization</strong>. Up to six different solvents can be used, including wash solvents for cleaning between methods. Precise flow control optimizes methods.</li><li><strong>Barcode-reading.</strong> The system tracks sample information and preparation parameters using a 2-D bar code reader to facilitate tracking and integrity. Data is recorded on the instrument or Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon™ Chromatography Data System (CDS) software</strong></a>.</li></ul><h4><strong>Specifications</strong></h4><ul><li><strong>Instrument Type:</strong> Automated Sample Preparation System</li><li><strong>Application:</strong> Simultaneous sample extraction and concentration</li><li><strong>Model Description:</strong> EXTREVA ASE Extraction and Evaporation System</li></ul><h5><strong>Performance &amp; Capabilities</strong></h5><ul><li><strong>Extraction Temperature Range:</strong> 40–200 °C</li><li><strong>Evaporation Temperature Range:</strong> 40–100 °C</li><li><strong>Compatible Solvents:</strong> Wide range of organic and aqueous solvents</li><li><strong>Pressure Capability:</strong> Up to 200 psi</li><li><strong>Power Consumption:</strong> 2000 W</li><li><strong>Frequency:</strong> 50/60 Hz</li></ul><h5><strong>Sample &amp; Solvent Handling</strong></h5><ul><li><strong>Extraction Cells (stainless steel):</strong> 1, 5, 10, 22, 34, 66, 100 mL</li><li><strong>Extraction Cell Tray:</strong> 16-position with 1 rinse</li><li><strong>Collection Vials:</strong><ul><li>60 mL and 100 mL evaporation vials</li><li>250 mL evaporation bottles</li><li>Direct concentrate to 2 mL sample vials with rinse capability</li></ul></li><li><strong>Collection Vial Tray:</strong> 16-position tray insert for 60 mL vials and 250 mL bottles; includes 4 rinse positions</li></ul><h5><strong>Utilities &amp; Requirements</strong></h5><ul><li><strong>Pneumatic Requirements:</strong><ul><li>Air: 130–140 psi</li><li>Nitrogen: 350–450 psi</li></ul></li></ul><h5><strong>Physical Specifications</strong></h5><ul><li><strong>Dimensions (D × W × H):</strong> 65.2 × 100 × 88.6 cm (25.6 × 39.4 × 34.8 in.)</li><li><strong>Weight:</strong> 160 kg (353 lb)</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific™ Dionex™ ASE™ 350 Accelerated Solvent Extractor

Save time, reduce solvent consumption, and boost productivity with Thermo Scientific™ Dionex™ ASE™ 350 Accelerated Solvent Extractor.

<div><p><strong>Automate extraction, filtration and clean up of compounds from solid and semisolid samples in minutes using the automated Thermo Scientific™ Dionex™ ASE™ 350 Accelerated Solvent Extractor. This system accommodates sample sizes of 1-100g, allows unattended extraction of up to 24 samples and uses 50 to 90% less solvent compared to other methods.&nbsp;</strong></p><p>The chemically inert pathway supports acid and alkaline sample matrices and solvents. Flexible, easy-to-operate and cost-effective, the Dionex ASE 350 is ideally suited for high-throughput laboratories and for a wide variety of applications.</p><div><h4><strong>Rapid and efficient extractions</strong></h4><ul><li>Elevated temperature (up to 200°C) and pressure (1500psi) reduce extraction times and solvent consumption</li><li>Fast pump (70mL/min.) enables fast extractions (typically 12-20 minutes)</li><li>Specialized oven design ensures precise temperature control for excellent reproducibility</li><li>Integrated solvent controller allows mixing and delivery of up to three solvents</li><li>The <strong>Thermo Scientific™ SmartRun™ System</strong> ensures cell size and collection vessel size are matched for an optimal extraction</li></ul><h4><strong>Enhanced flexibility to support multiple applications</strong></h4><ul><li>System accommodates <strong>1, 5, 10, 22, 34, 66 </strong>and <strong>100mL cell sizes</strong></li><li>pH-hardened pathway with <strong>Thermo Scientific™ Dionium™ components and cell</strong> enables compatibility with acid or alkaline pretreated matrices</li></ul><h4><strong>Dramatically reduced solvent consumption</strong></h4><ul><li>Requires less than 50mL solvent for a 20g sample</li><li>Includes solvent saver mode for further solvent savings</li></ul><h4><strong>Enhanced laboratory productivity</strong></h4><ul><li>System holds up to 24 samples for unattended operation</li><li>Flow-through technology allows in-line filtration and in-cell cleanup</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_ASE_350_system_2_9426ff3f9a/Thermo-Scientific-Dionex-ASE-350-system_2.jpg" alt="Thermo Scientific™ Dionex™ ASE™ 350 Accelerated Solvent Extractor" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_ASE_350_system_2_9426ff3f9a/thumbnail_Thermo-Scientific-Dionex-ASE-350-system_2.jpg 114w," sizes="100vw" width="579" height="792"></p><h3><strong>🛠️ Specifications</strong></h3><ul><li><strong>Collection Vial Tray</strong>: 26-position tray insert for 60 mL vials; 19-position tray insert for 250 mL bottles</li><li><strong>Depth (English)</strong>: 27.3 in.</li><li><strong>Depth (Metric)</strong>: 69.3 cm</li><li><strong>Description</strong>: Extractor Only</li><li><strong>Extraction Fluids</strong>: Compatible with a wide range of organic and aqueous solvents</li><li><strong>Fluid Sensors</strong>: IR</li><li><strong>Frequency</strong>: 50/60 Hz</li><li><strong>Height (English)</strong>: 24.3 in.</li><li><strong>Height (Metric)</strong>: 61.7 cm</li><li><strong>Pneumatic Requirements</strong>: Air at 400–827 kPa (60–120 psi); N2 (at 1034 ×–1340 kPa (150–200 psi))</li><li><strong>Power Consumption</strong>: 500 Max VA</li><li><strong>Pressure</strong>: 10 MPa (1500 psi)</li><li><strong>Pump Flow</strong>: 70 mL/min</li><li><strong>Temperature Control</strong>: Up to 200 °C</li><li><strong>Weight (English)</strong>: 140 lb.</li><li><strong>Weight (Metric)</strong>: 65 kg</li><li><strong>Width (English)</strong>: 26.5 in.</li><li><strong>Width (Metric)</strong>: 67.3 cm</li><li><strong>Collection Vials</strong>: 60, 250 mL</li><li><strong>Dimensions (D x W x H)</strong>: 69.3 x 67.3 x 61.7 cm</li><li><strong>Extraction Cell Tray</strong>: 24 Cell, 2 Rinse</li><li><strong>Extraction Cells</strong>: 1, 5, 10, 22, 34, 66, 100 mL</li><li><strong>For Use With (Equipment)</strong>: Dionex ASE 350</li><li><strong>Type</strong>: Dionex ASE 350 System</li><li><strong>Unit Size</strong>: Each</li></ul></div></div>

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