<blockquote><p>Welcome back to the topic of protecting your GC column! <strong>If you missed part 1</strong> or would like to refresh your knowledge, find further tips on GC column protection <a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/knowledge-center/gc-knowledge-center/protecting-your-gc-column-pt1-tech-tip-en-1025"><strong>here</strong>.</a></p></blockquote><p><strong>Protecting your GC column and instrument components from exposure to dirty samples or contaminants is important. Non-volatile or high molecular weight components can contaminate the stationary phase, causing poor peak resolution, lower accuracy, and poor column lifetime. Cutting off the damaged portion of column tubing will often restore your column’s performance, but over time performance will degrade to a point where the column can no longer be used. If you are experiencing rapid degradation of column performance, there are several simple ways to help protect your column and increase its lifetime.</strong></p><h3><strong>Use A Liner With Wool</strong></h3><p>The liner is the first line of defense for your column, and the style you choose can make a big impact in how much contamination gets onto the column. The easiest thing to do is to add a small amount of silanized glass wool to a liner, which traps the non-volatile compounds and prevents them from entering directly into the column.&nbsp;</p><blockquote><p><strong>Caution: </strong>glass wool can also add activity for acids, bases, and pesticides. Crushing the glass wool can expose undeactivated glass and free silanols (-OH groups) even if the wool has been deactivated. This leads to increased activity, so pre-packed liners, rather than self-packed ones are highly recommended to avoid reproducibility issues.</p></blockquote><p>In addition to choosing a liner with wool, ensure that your liner (and other system consumables) are free of contaminant build-up that may form over time. Septum cores and other particulates that remain can become trapped in the wool and are sometimes difficult to spot. Regularly replace the liner (and other system consumables as needed) to reduce troubleshooting and maintenance.</p><h3><strong>Bake Out Your Column</strong></h3><p>The easiest way to reduce column contamination is to add a short, high temperature bake-out at the end of your standard GC method. This bake out helps remove high boiling contaminants that would otherwise remain in the column and cause damage. To bake out, the final oven temperature needs to be set high enough to ensure elution of these compounds, but not so high as to cause thermal damage. This can be done either isothermally, or more commonly, via an oven ramp until the last components elute from the column. Caution: NEVER exceed the upper temperature limits of your column. DO NOT exceed more than fifteen minutes at the upper isothermal temperature limit specified for the column.</p>

How to Protect Your GC Column - Part 2

<p>🎤 <strong>Presenter</strong>: Christopher Freye (Los Alamos National Laboratory)</p><p>💾 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_1_Freye_10783a9cf3.pdf"><strong>PDF presentation</strong></a></p><h3><strong>Abstract</strong></h3><p><strong>Two-dimensional gas chromatography (</strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?instrumentationItems=2"><strong>GC×GC</strong></a><strong>) when coupled with mass spectrometry (MS) especially high-resolution mass spectrometry (HRMS) provides the ideal technique to discover minute chemical changes. However, GC×GC analyses result in extremely large datasets (GBs of information) wherein the statistically significant chemical changes are buried within the background chemical matrix. To combat these issues, many chemometric techniques have been developed or applied. Recently we introduced a new chemometric technique for GC-MS termed alteration analysis (ALA) and two-dimensional correlation (2DCOR) which can be used to discover statistically significant chemical changes across a series of chromatograms and understand the relationship between the statistically relevant changes. ALA generates three sets of information, the basic alteration map (BAM) which is the magnitude of the change, the synchronous alteration map (SAM) which describes the linear change, and the asynchronous alteration map (AAM) which describes the non-linear change. 2DCOR can then be used to understand the relationship between the chemical changes but 2DCOR can also resolve the sequence of the changes. A workflow for GC×GC-MS will be demonstrated. Special attention will be given to what differentiates the GC×GC work flow from GC for both the ALA and 2DCOR.</strong></p><h3><strong>Video Transcription</strong></h3><p>The presentation focuses on how <strong>advanced mathematical and chemometric methods</strong> can be used to extract meaningful information from <strong>highly complex chromatographic data</strong>, especially in <strong>multidimensional chromatography coupled with mass spectrometry (GC×GC-MS, LC-MS)</strong>.</p><h4><strong>Why traditional data analysis falls short</strong></h4><p>Modern multidimensional chromatography generates <strong>extremely large datasets</strong>, often containing <strong>billions of data points</strong>. Visual inspection, peak tables, or classical identification-based workflows are impractical—especially when:</p><ul><li>Samples are highly complex (e.g. petroleum, metabolomics, high explosives)</li><li>Most compounds are <strong>unknown unknowns</strong></li><li>The key question is not <i>what</i> the compounds are, but <strong>whether samples differ and how</strong></li></ul><p>Program managers and decision-makers are primarily interested in <strong>detecting statistically significant changes</strong>, not exhaustive compound identification.</p><h4><strong>Introduction of Alteration Analysis (ALA)</strong></h4><p>To address subtle, trend-based changes across series of chromatograms, the speaker introduces <strong>Alteration Analysis (ALA)</strong>, a chemometric approach adapted from spectroscopy and applied to chromatography.</p><p>ALA quantitatively evaluates how <strong>individual data points change across multiple samples</strong>, allowing detection of:</p><ul><li>Extremely subtle trends</li><li>Overlapping peaks</li><li>Changes hidden in noise or baseline interference</li></ul><p>Key ALA outputs include:</p><ul><li><strong>BAM (Basic Alteration Map):</strong> magnitude of change</li><li><strong>SAM (Systematic Alteration Map):</strong> linear changes</li><li><strong>AM (Alteration Map):</strong> nonlinear changes</li></ul><p>Even changes as small as <strong>1% per sample</strong> can be detected reliably, including peaks that are heavily overlapped.</p><h4><strong>Beyond detection: understanding relationships with 2D Correlation</strong></h4><p>Once statistically significant changes are identified, <strong>two-dimensional correlation analysis (2D-COR)</strong> is used to understand <strong>relationships between changing compounds</strong>, including:</p><ul><li>Whether compounds are correlated or anti-correlated</li><li>The <strong>sequence of changes over time</strong> (which changes happen first)</li></ul><p>This is especially critical for <strong>degradation and aging studies</strong>, where intermediate species may appear and disappear before the final state—information that traditional methods like Fisher ratio or PCA often miss.</p><h4><strong>Solving GC×GC challenges with tiling</strong></h4><p>GC×GC data introduces additional challenges due to:</p><ul><li>Peak misalignment</li><li>Exponential data growth during correlation calculations</li></ul><p>The presenter explains how <strong>tile-based approaches</strong> reduce data dimensionality, overcome alignment issues, and make ALA and 2D correlation computationally feasible—even for massive GC×GC-MS datasets.</p><h4><strong>Real-world application: explosive aging studies</strong></h4><p>The methodology was applied to <strong>aging and decomposition of high explosives</strong>, where:</p><ul><li>Over <strong>250 chemical changes</strong> were identified</li><li>Many intermediate species would have been missed using traditional comparisons</li><li>ALA combined with 2D correlation enabled reconstruction of <strong>degradation pathways</strong></li><li>The most significant change was <strong>not necessarily the first change</strong>, a critical insight for risk assessment and stability studies</li></ul><h4><strong>Key takeaway</strong></h4><p>By combining <strong>Alteration Analysis and 2D correlation</strong>, the approach:</p><ul><li>Detects statistically guaranteed chemical changes</li><li>Handles subtle, overlapped, and noisy signals</li><li>Determines <strong>magnitude, type, interrelationships, and order of changes</strong></li><li>Shifts chromatographic data analysis from identification-driven to <strong>decision-driven</strong></li></ul><p>This math-driven workflow enables faster, more reliable interpretation of complex chromatographic datasets and provides actionable insights for applications such as <strong>explosive aging, pharmaceutical degradation, and complex mixture analysis</strong>.</p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote>

Discovery analysis for GCxGC trends using alteration and 2D correlation (Chris Freye, MDCW 2026)

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 9th February 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you technical note by <strong>Agilent Technologies, </strong>presentation by<strong> MDCW / University of Copenhagen </strong>and<strong> </strong>application notes by<strong> Shimadzu </strong>and<strong> Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: What Causes Spots on </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?instrumentationItems=19&amp;manufacturerItems=1&amp;search=PLOT"><strong>PLOT Columns</strong></a><strong>? Will It Affect the Performance of the Column?</strong></h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_what_causes_spots_plot_columns_affecting_performance_5994_8775en_agilent_3b7180512a.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Spots on porous layer open tubular (PLOT) columns are caused by small voids in the stationary phase coating inside the tube. These spots are areas where there is an uneven coating or lack of phase. It is normal to find some voids in the phase coating of PLOT columns. The stationary phase in PLOT columns is an opaque, solid, and porous material. In many Agilent PLOT columns such as the GS-Alumina phases, molecular sieves, porous polymers (Q and U), and the GS-OxyPLOT, the stationary phase is visible as a white powder. For many PLOT columns, the stationary phase fill solution is a viscous suspension of particles that are less than 10 microns in diameter. The phase is coated using a dynamic process in which a plug of fill solution is pushed through the tubing, and the plug’s speed and viscosity determines the thickness of the stationary phase layer. Once the PLOT’s stationary phase is deposited, it is held in place by electrostatic charge, chemical interactions between particles, and/or binding agents. In wall‑coated open tubular (WCOT) columns, stationary phases such as polysiloxanes or polyethylene glycols are immobilized by chemical bonding to the glass surface and cross-linking between polymer strands. Because this type of bonding and cross‑linking is not possible with PLOT phases, the result is a stationary phase layer that is both fundamentally different and inherently less stable in PLOT columns than in WCOT&nbsp;columns.</p><h3><strong>2. MDCW / University of Copenhagen: One-shot tensor decomposition of full-scale GC×GC-VUV datasets for resolving petrochemical groups</strong></h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_17_Schneide_67c8ff7866.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The presentation introduces a novel <strong>all-samples-at-once, shift-invariant tri-linear tensor decomposition approach</strong> for the analysis of full-scale <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?search=GC%C3%97GC-VUV"><strong>GC×GC-VUV</strong></a><strong> datasets</strong>, aimed at resolving and quantifying petrochemical groups. Traditional template-based or pixel-based methods struggle with retention-time shifts and co-eluting compounds, often requiring manual intervention and prior chemical knowledge. The proposed approach leverages the intrinsic low-rank structure of GC×GC-VUV data to enable robust, automated group-level analysis across multiple samples simultaneously.</p><p>At the core of the method is a <strong>shift-invariant tri-linear model</strong>, conceptually related to PARAFAC and multivariate curve resolution, but extended using frequency-domain (FFT-based) modeling to explicitly account for chromatographic peak shifts. By decomposing the entire dataset in one step, the model provides <strong>accurate estimates of peak landscapes, VUV spectra, and relative peak areas</strong>, while remaining agnostic to retention-time variability. Importantly, the approach requires only a small number of tunable parameters, making it practical for routine use.</p><p>The method was demonstrated on a <strong>case study involving 14 petrochemical gas-oil samples</strong>, including straight-run, hydrotreated, hydroconverted, coker, and light cycle oils. Extracted VUV spectra showed excellent agreement with reference spectra from a VUV spectral database, enabling confident assignment of components to chemical groups such as saturates, olefins, and mono- to poly-aromatics. Quantitative results exhibited <strong>high repeatability (RSD typically 3–9%)</strong> and strong correlation with established template-based reference methods.</p><p>Overall, the work demonstrates that <strong>one-shot, shift-invariant tensor decomposition</strong> provides a powerful and scalable alternative to conventional GC×GC data-analysis strategies. By combining chemical interpretability, robustness to chromatographic shifts, and strong quantitative performance, the approach opens new opportunities for automated, high-confidence group-level analysis of complex petrochemical samples and beyond.</p><h3><strong>3. Shimadzu: Py-Screener Ver. 3: Simultaneously Test for Substances Regulated Under RoHS, TSCA, and POPs</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00949_en_4754e50164.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>In just one analysis, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=Py-Screener"><strong>Py-Screener</strong></a> Ver. 3 can determine levels of phthalate esters, brominated flame retardants (PBBs, PBDEs), PIP (3:1), UV-328, dechlorane plus (DP), short-chain chlorinated paraffins (SCCPs), and medium-chain chlorinated paraffins (MCCPs).&nbsp;</li><li>It can also test for SCCPs and MCCPs by electron ionization (EI) instead of negative chemical ionization (NCI).&nbsp;</li><li>PIP (3:1), UV-328, DP, and SCCPs and MCCPs can be screened without the need for corresponding reference materials.</li></ul><p>Countries and regulatory bodies worldwide are introducing increasingly stringent regulations on the chemical substances used in electronic devices and industrial products. The RoHS Directive and REACH regulations in the EU, the Toxic Substances Control Act (TSCA) in the USA, and the Stockholm Convention on Persistent Organic Pollutants (POPs) are also targeting an increasingly broad range of substances. Therefore, manufacturers are required to accurately identify regulated substances in their products and comply with each regulation. While Py-Screener Ver. 2 can screen for seven phthalate esters and brominated flame retardants, including substances regulated under the RoHS Directive, version 3 can also screen for PIP (3:1), which is regulated under the TSCA, as well as UV328, DP, and SCCPs and MCCPs , which are regulated under the Stockholm Convention on POPs. A list of supported substances isshown in Table 1. This article introduces the simultaneous analysis of multiple regulated substances and a case study of testing specific regulated substances in samples, using Py-Screener Ver. 3.</p><h4><strong>Analysis Process</strong></h4><p>Py-Screener Ver. 3 can determine levels of phthalate esters and brominated flame retardants contained in products in accordance with the international analytical standards IEC62321-8 and IEC62321-3-3. It can also test for specific regulated substances (Table 1) under the same conditions and in the same analysis. In this test, background intensity and instrument sensitivity (S/N) were verified before analyzing samples. These parameters are prescribed by IEC62321-8 to ensure the accuracy of the methods used. Background intensity and instrument sensitivity were determined using a reference material (PN: 225-31003- 91) *1 that consisted of a plastic sheet that was spiked with seven phthalate esters. The results met the criteria for both parameters.</p><p>The testing workflow is shown in Fig. 1. Before testing samples, calibration curves were prepared by analyzing the 1000 mg/kg phthalate ester reference material and polypropylene spiked with brominated flame retardants (ERM-EC591). A hole puncher was used to punch out two discs at a time of the phthalate ester reference material, and a cutter was used to obtain pieces of the other materials. Each material was weighed in a sample cup for analysis. During the analysis of samples, phthalate esters and some of the regulated brominated flame retardants were quantitated using a one-point calibration curve. The remaining brominated flame retardants and specific regulated substances were quantitated using the correction factor database*2 that is included with Py-Screener Ver. 3.</p><h4><strong>Conclusion</strong></h4><p>Py-Screener Ver. 3 successfully determined in samples the concentrations of the regulated substances PIP (3:1), UV-328, DP, and SCCPs and MCCPs. Normally, SCCP and MCCP levels are tested using NCI, but Py-Screener Ver. 3 uses EI. This enables it to test for not only SCCPs and MCCPs but also phthalate esters, brominated flame retardants, and other regulated substances in just one analysis. In addition, by using the relative correction factors linked to DEHP in the phthalate ester reference material, the levels of these regulated substances were determined without the need for the corresponding reference materials. Py-Screener Ver. 3 can also create a screening program that addresses substance restrictions under the RoHS Directive, the US TSCA, and the POPs Convention.</p><h3><strong>4. Thermo Fisher Scientific: Improving low carbon steel production in specialty steel processes</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/prima_pro_process_mass_spectrometer_an1626_7fc840235f.pdf"><strong>Full PDF for download</strong></a></li></ul><p>World crude steel production reached 1,691 million tonnes in 2017, up by 5.3% compared to 2016.1 While much of this capacity is still produced in primary steel processes such as basic oxygen furnaces and electric arc furnaces, the need for refined steel with greater durability and resistance to heat and corrosion has led to the increased use of vacuum degassing processes, such as VOD and RH, in secondary steel production. These processes are able to achieve ultra-low levels of residual carbon, while at the same time retaining desired levels of other alloy materials. If these processes are to achieve the required level of steel product quality, they need fast, continuous gas analysis of the furnace exhaust gas. Without accurate information on the composition of the gas leaving the furnace, any variations in the decarburization process are only detected after the event, resulting in the production of out-of-specification steel.</p><h4><strong>Advantages of mass spectrometry&nbsp;</strong></h4><p>Traditional Non-Dispersive Infra-Red (NDIR) analyzers are used in many conventional steelmaking processes to measure CO and CO<sub>2</sub> , but they can only sample at atmospheric pressure. In vacuum steelmaking the process pressure changes dramatically, typically from atmospheric pressure down to less than 1 mbar, over the 20-30 minutes of the melt. So NDIR analyzers have to sample some distance downstream from the process. Analytical data is updated several minutes after the gas leaves the melt and the control system is forced to operate on historic rather than real-time data.&nbsp;</p><p>Paramagnetic analyzers can be used to measure O<sub>2</sub> , while thermal conductivity analyzers can be used to measure H<sub>2</sub> . These analyzers also suffer from slow response, while the need to operate three different types of analyzers adds to the plant maintenance burden. Moreover, the three analyzers cannot analyze inert gases, so N<sub>2</sub> is calculated by difference, a result that suffers from the sum of the errors of the three analytical techniques.&nbsp;</p><p>Mass spectrometry operates at high vacuum so it is ideal for monitoring vacuum processes. It is also able to monitor all seven components in Table 1 in seconds rather than minutes, ensuring the plant control model is frequently updated with accurate compositional data.</p><h4><strong>Precision of analysis&nbsp;</strong></h4><p>At the heart of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=Prima+PRO+Mass+Spectrometer"><strong>Thermo Scientific™ Prima PRO Mass Spectrometer</strong></a> (MS) is a magnetic sector analyzer which offers unrivalled precision and accuracy compared with other mass spectrometers. Thermo Fisher Scientific manufactures both quadrupole and magnetic sector mass spectrometers; over thirty years of industrial experience have shown the magnetic sector based analyzer offers the best performance for industrial on-line gas analysis.&nbsp;</p><p>Key advantages of magnetic sector analyzers include improved precision, accuracy, long intervals between calibrations, and resistance to contamination. Typically, analytical precision is between 2 and 10 times better than a quadrupole analyzer, depending on the gases analyzed and complexity of the mixture.&nbsp;</p><p>A unique feature of the Prima PRO magnet is that it is laminated. Its analysis times are similar to a quadrupole analyzer, offering the unique combination of rapid analysis and high stability. This allows the rapid and extremely stable analysis of an unlimited number of user-defined gases. The scanning magnetic sector is controlled with 24-bit precision using a magnetic flux measuring device for extremely stable mass alignment.&nbsp;</p><p>The ion source is an enclosed type for high sensitivity, minimum background interference, and maximum contamination resistance. This is a high-energy (1000 eV) analyzer that offers extremely rugged performance in the presence of gases and vapors that have the potential for contaminating the analyzer. Typical performance specifications for the Prima PRO MS are shown in Table 1. Analytical performance is demonstrated by analyzing the calibration bottle over 1 hour following calibration, with an analysis time of just 6 seconds. Standard deviations measured on the calibration cylinder will be equal to or better than the stated values.</p>

News from LabRulezGCMS Library - Week 07, 2026

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The Multidimensional Chromatography (MDC) Workshop draws experts in this exciting field to share and discuss their research.

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Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in industrial, government and academic laboratories.

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Thermo Scientific™ TSQ™ 9000 GC-MS/MS System

Triple quadrupole GC-MS/MS system offering exceptional sensitivity, robustness, and smart automation for trace-level quantitation in food, environmental, and forensic analysis.

<p><strong>High-performance triple quadrupole GC-MS/MS platform for routine trace-level quantitation in complex matrices</strong></p><p>The <strong>TSQ™ 9000 GC-MS/MS system</strong> is built for laboratories that demand <strong>uncompromising sensitivity, throughput, and robustness</strong> for trace-level analysis in <strong>food safety, environmental, and forensic/toxicology applications</strong>. Designed to increase productivity and reduce cost-per-sample, this system delivers best-in-class performance with intuitive tools for routine and advanced users alike.</p><h3><strong>Key features and benefits</strong></h3><h4>🚀 <strong>Unstoppable Sensitivity</strong></h4><ul><li><strong>Advanced Electron Ionization (AEI)</strong> source for attogram-level sensitivity, ideal for demanding applications like dioxins and pesticides in baby food.</li><li><strong>ExtractaBrite™ ion source</strong>: robust EI/CI performance, proven in routine use; fully removable under vacuum with NeverVent™.</li><li><strong>Ionization modes: </strong>EI, PCI, NCI (CI available with ExtractaBrite only)</li></ul><h4>🔬 <strong>Unstoppable Performance</strong></h4><ul><li><strong>EvoCell™ collision cell</strong>: up to 800 SRM transitions/s with excellent precision</li><li><strong>0.5 ms minimum dwell time</strong>; up to 97 scans/s; 20,000 u/s quadrupole scan speed</li><li><strong>Mass range</strong>: 1.2–1100 u, unit mass resolution</li><li><strong>Mass stability</strong>: &lt;0.1 u over 48 h</li></ul><h4>🔧 <strong>Unstoppable Uptime</strong></h4><ul><li><strong>NeverVent™ technology</strong> (with VPI &amp; ExtractaBrite): perform maintenance or column changes without venting</li><li><strong>V-Lock</strong> column isolation prevents system venting during GC maintenance</li><li><strong>Dual heated source lenses</strong> for minimal contamination and high matrix tolerance</li></ul><h3><strong>Ease of Use and Intelligent Method Development</strong></h3><ul><li><strong>AutoSRM™</strong>: Automated SRM development wizard</li><li><strong>SIM Bridge™</strong>: Convert legacy SIM methods into SRM in seconds</li><li><strong>Timed-SRM and Retention Time Alignment (RTA)</strong>: Maintain optimal sensitivity and peak tracking across injections</li><li><strong>SmartTune™</strong>: Intuitive system tuning with error guidance</li></ul><h3><strong>Software Platforms</strong></h3><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon™ CDS</strong></a></h4><ul><li>Fully integrated control of chromatography and mass spectrometry</li><li>One-click eWorkflows™, Intelligent Run Control, automated compliance tools</li><li>Environmental Analysis Extension Pack for U.S. EPA workflows</li></ul><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/77"><strong>TraceFinder™</strong></a></h4><ul><li>Comprehensive solution for method development, acquisition, processing, and reporting</li><li>Preloaded SRM database for over 1300 pesticides (environmental/food safety versions)</li><li>Application-specific variants for <strong>clinical research</strong>, <strong>toxicology</strong>, and <strong>environmental labs</strong></li></ul><h3><strong>System Specifications</strong></h3><ul><li><strong>Ion sources</strong>: AEI and ExtractaBrite (CI optional)</li><li><strong>Transfer line temperature</strong>: up to 400 °C</li><li><strong>Detector</strong>: DynaMax™ XR system with off-axis dynode and wide dynamic range (&gt;10⁷)</li><li><strong>Mass resolution</strong>: Adjustable 0.4–2.5 u, preset or manual</li><li><strong>Pumping system</strong>: High-capacity turbomolecular with rotary vane or optional oil-free scroll</li><li><strong>Direct Probe Options (VPI only)</strong>: DIP and DEP probes for solid and rapid samples</li></ul><h3><strong>Sample Introduction Options</strong></h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/68"><strong>AI/AS 1310 Autosampler</strong></a>: high-precision injections, advanced rinse protocols</li><li><strong>TriPlus™ RSH Autosampler</strong>: robotic automation including dilution, internal standard addition, derivatization, and tool switching</li></ul><h3><strong>System Dimensions and Compatibility</strong></h3><ul><li>Fully compatible with <strong>Thermo Scientific™ TRACE™ 1300/1310 GC</strong></li><li><strong>Mass spectrometer</strong>: 44 × 40 × 89 cm; 61 kg</li><li>Modular design enables scalable performance and easy upgrades</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/application::product.product/Thermo-TSQtm-9000-1310-triplus-rsh_l.webp" alt="Thermo Scientific™ TSQ™ 9000 GC-MS/MS System" width="708" height="708"></p>

Thermo Scientific TSQ 9610 Triple Quadrupole GC-MS

The Thermo Scientific TSQ 9610 triple quadrupole GC-MS/MS systems is the best-in-class system for ultimate sensitivity and quantitation of targeted compounds. Optimized for high-throughput analytical laboratories.

<div><div id="product-description"><p><strong>To confidently stay ahead, your GC-MS/MS system must deliver ultimate performance while consistently producing trusted quantitative results. For this, turn to the Thermo Scientific™ TSQ™ 9610 Triple Quadrupole GC-MS/MS System. User-centric Thermo Scientific™ NeverVent™ technology, extended-life detector, and intelligent software eliminate unnecessary downtime to maximize your sample throughput and return on investment (ROI). New extended linear dynamic range combined with proven high sensitivity ensures you keep ahead of the toughest regulatory methods and business demands.</strong></p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/mass-spectrometry/gas-chromatography-mass-spectrometry-gc-ms/gc-ms-systems/triple-quadrupole-gc-ms.html"><strong>Discover TSQ 9610 GC-MS highlights</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/store/instruments/configurators/trace1600"><strong>Build your GC-MS system</strong></a></li></ul></div><div><h4><strong>Increase instrument uptime</strong></h4><p>Eliminate unnecessary, unplanned instrument downtime to deliver high-confidence quantitative results, day after day. The TSQ 9610 Triple Quadrupole GC-MS/MS System combines unstoppable robustness with the ability to change the GC column and clean the ion source without interrupting analytical workflows.<br><br>Monitor key aspects of your GC-MS system. With Thermo Scientific™ SmartStatus™ instrument tracking within Chromeleon CDS, quickly see whether instruments are ready to run samples, if maintenance is required or if consumables should be replaced. The fully customizable software enables you to make data-driven decisions on when to perform maintenance and avoid unnecessary downtime.</p><h4><strong>Maximize sample throughput</strong></h4><p>When high sample throughput is essential, the system delivers results on time and with ease. Automated workflows and simplified operation ensure every user produces consistent results, sample after sample. Extended linear range and rapid selected reaction monitoring (SRM) scanning enable method consolidation so you can analyze more compounds in a single run. When these capabilities are combined with best-in-class uptime and sensitivity, you stay ahead of any productivity demand.</p><h4><strong>Realize rapid return on investment&nbsp;</strong></h4><p>Ensuring your system delivers results as soon as it’s installed is necessary to achieve rapid ROI. With built-in intelligence that simplifies instrument setup, analytical methods, and everyday operation, the TSQ 9610 Triple Quadrupole GC-MS/MS System is designed for accelerated deployment. Reduced needs for operator training and faster time to full productivity together with maximum sample throughput provide fast return on your instrument</p><h3><strong>TSQ 9610 GC-MS/MS highlights</strong></h3><h4><strong>Unstoppable confidence in quantitative performance</strong></h4><p>Delivering attogram-level sensitivity and best-in-class selected reaction monitoring (SRM) performance, the TSQ 9610 GC‑MS/MS system consistently meets required detection limits as you run samples. Choose the rugged Thermo Scientific ExtractaBrite ion source or the ultra-sensitive, ultra-robust Thermo Scientific Advanced Electron Ionization (AEI) ion source, depending on your sensitivity needs.</p><p>The XLXR electron multiplier detector which extends dynamic range twofold compared to the previous design. Extended dynamic range capability enables labs to combine methods, including calibration curve development, allowing analysis of low- and high-concentration compounds in a single run.</p><div container-id="cq-colctrl-lt0" comp-id="A2"><div><h4><strong>Unstoppable confidence in uptime for full-time productivity</strong></h4><p>The TSQ 9610 GC-MS/MS system is specifically designed for complex sample matrices in high-throughput applications.&nbsp;Using NeverVent technology with the Vacuum Probe Interlock (VPI) and V-Lock source plug, planned maintenance such as changing column and ion source cleaning can be performed without venting the mass spectrometer, increasing uptime. NeverVent technology is available on both the Thermo Scientific ExtractaBrite and the Thermo Scientific NeverVent Advanced Electron Ionization (NV-AEI) sources.</p></div></div><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h4><strong>Unstoppable confidence in your investment</strong></h4><p>Rapid instrument deployment reduces time to results and revenue generation. That’s why the TSQ 9610 Triple Quadrupole GC-MS/MS System includes a comprehensive set of automated tools to provide users with a seamless experience when transitioning from other platforms, developing methods, and analyzing samples. This built-in intelligence reduces operator training needs and time to full productivity for rapid ROI.</p></div></div></div><h4><strong>Unstoppable confidence in sample throughput</strong></h4><p>Maximizing sample throughput is essential to producing results on time. The TSQ 9610 Triple Quadrupole GC-MS/MS System incorporates user-centric innovations that extend service intervals, reduce maintenance, and allow methods consolidation to boost sample throughput while maintaining certainty in quality of results.</p></div></div>

Waters Xevo TQ-GC Mass Spectrometry System

The Xevo TQ-GC allows routine quantitation of multiple contaminants in matrix sample. The consistent high performance allows regulatory limits to be comfortably passed reducing the need for frequent user intervention and re-optimization.

<div><div><h4><strong>The perfect addition to your laboratory</strong></h4></div></div><div><div><p><strong>Demands to meet regulations are increasing pressure on laboratories, and in order to meet these challenges laboratories must develop and run methods that provide high-quality, consistent results, day in and day out.&nbsp;</strong></p><div><div><div><div><p>The <strong>Xevo TQ-GC</strong> is a robust <strong>Electron Ionization (EI) and Chemical Ionization (CI)</strong> Gas Chromatography (GC)-MS/MS platform that allows <strong>routine quantification of multiple contaminants in complex matrices</strong>. The <strong>Xevo TQ-GC</strong> consistently <strong>surpasses the sensitivity required to meet regulatory limits</strong>, thus reducing the need for frequent user intervention and re-optimization. In addition, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635"><strong>MassLynx Software </strong></a><strong>security</strong> controls user access, giving you more control to assist with laboratory compliance.</p><p>Laboratories can also <strong>develop methods rapidly using Quanpedia</strong>, which allows fast response to changes in legislative demands and for customized methods. All the speed, sensitivity, and reliability you have come to expect from Xevo now with GC-MS/MS.</p><ul><li><strong>Reduce training time and costs</strong> with a single software workflow for GC-MS/MS and LC-MS/MS analysis</li><li><strong>Achieve comprehensive application coverage</strong> powered by Quanpedia database driven workflow</li><li><strong>Easily surpass regulatory limits</strong> with fit-for-purpose performance in difficult matrices</li><li><strong>Choose from a wide range of injection modes</strong>, including liquid, headspace, and solid phase microextraction (SPME) analysis</li><li><strong>Control access to the GC-MS system</strong> to meet regulatory requirements with MassLynx security</li><li><strong>Simplify maintenance tasks</strong> with a rapid and mistake-proof source design</li></ul></div></div><div><div><h4><strong>Recommended Use</strong></h4><p>For routine quantitation of multiple contaminants in an extracted matrix sample.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_GC_Mass_Spectrometry_System_4_fda01dffa7.jpg" alt="Waters Xevo TQ-GC Mass Spectrometry System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_GC_Mass_Spectrometry_System_4_fda01dffa7.jpg 245w," sizes="100vw" width="1024" height="606"></p><div><div><h3><strong>Maximize uptime to ensure your success</strong></h3><p>Ensuring you achieve <strong>reliable and predictable results</strong> is at the heart of the design of the Xevo TQ-GC. The system has been rigorously tested to ensure that you <strong>spend less time on routine maintenance</strong>, and that it can be scheduled to fit around the laboratory workload, <strong>maximizing uptime</strong> and <strong>minimizing disruption</strong>.</p><p>To ensure you don’t spend your precious time on lengthy instrument setup, <strong>Intellistart health check</strong> informs you whether the system is ready to run injections and, if not, how the situation can be remedied. Your lab only needs <strong>minimal tools for instrument maintenance</strong>, and if any maintenance is needed, it is <strong>fast and mistake-proof</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_GC_Mass_Spectrometry_System_5_ebae58fe9d.jpg" alt="Waters Xevo TQ-GC Mass Spectrometry System: Repeatability from replicate (n=200) injection of grape extract containing five pesticides at 0.01 mg/kg." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_GC_Mass_Spectrometry_System_5_ebae58fe9d.jpg 245w," sizes="100vw" width="1024" height="541"></p></div></div><div><div><h3><strong>Achieve efficiency and flexibility</strong></h3><p>In a busy analytical lab, time is precious, especially when demands change regularly and the requirement for shorter turnaround times is increasing. With <strong>Quanpedia</strong>, you can easily deal with a wide variety of sample matrices, target analytes and gas chromatography (GC) conditions. The <strong>fully customizable database</strong> means that you no longer need to be concerned about having the flexibility to adapt to changes in regulations, as it contains compound classes that are most relevant to regulations, and modifications to existing methods are quick and simple. You can reduce your method development time by including automatic scheduling of multiple reaction monitoring (MRM) transitions that account for any shift in retention times that occur because of column maintenance.</p><p>You can also <strong>shorten turnaround times</strong> by <strong>increasing the number of components in a single analytical run</strong>, which is enabled by <strong>acquisition rates of up to 500 MRM/sec</strong> with no significant degradation in performance. This means more MRM transitions can be added to a run while still achieving high quality results.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_GC_Mass_Spectrometry_System_caab24f949.jpg" alt="Waters Xevo TQ-GC Mass Spectrometry System: Generation of GC-MS acquisition and processing methods is performed automatically." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_GC_Mass_Spectrometry_System_caab24f949.jpg 245w," sizes="100vw" width="1024" height="546"></p></div></div><div><div><h3><strong>Capture the whole picture in targeted analyses</strong></h3><p>Reduce the risks to method performance and data quality associated with undetected interferences and unexpected compounds when conducting targeted analysis. <strong>RADAR improves method development and aids troubleshooting</strong> with the ability to detect and confirm analytes not specifically targeted through NIST library confirmation and routinely characterize unexpected contaminants. With this additional information, you can be completely confident in your data and avoid additional confirmatory analyses.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_GC_Mass_Spectrometry_System_2_48915d33e6.jpg" alt="Waters Xevo TQ-GC Mass Spectrometry System: Use of RADAR and NIST library search to identify a co-extracted compound in green tea matrix." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_GC_Mass_Spectrometry_System_2_48915d33e6.jpg 245w," sizes="100vw" width="1024" height="286"></p></div></div><div><div><h3><strong>Confidently meet regulatory demands</strong></h3><p>To ensure confidence in results, most analysts would prefer to operate comfortably below regulatory limits. You can achieve this confidence with Xevo TQ-GC, not only through <strong>reliable high performance</strong> but also as a result of <strong>TargetLynx</strong>, an Application Manager common across Waters LC and GC platforms. This means it not only gives full analyte quantification, simplified review of results, and customizable reporting, but also provides a common platform between instrument types simplifying data processing and reducing time to results.</p><p>With <strong>Waters MassLynx Basic Security</strong>, you are in control. Ideal for laboratories who need to manage or control access to a GC-MS system. MassLynx Basic Security contains an events audit log for added traceability for audits and accreditation, and the security can also be used with TargetLynx acquisition software.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_GC_Mass_Spectrometry_System_3_a0c5238bfe.jpg" alt="Waters Xevo TQ-GC Mass Spectrometry System: Comprehensive and streamlined results review with TargetLynx flags any results outside user-defined tolerances." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_GC_Mass_Spectrometry_System_3_a0c5238bfe.jpg 245w," sizes="100vw" width="1024" height="499"></p></div></div></div></div></div></div></div></div>

Products from category Triple quadrupoles focused on GC/QQQ - page 1

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