<p><strong>In September 2026, Prague will become a global meeting point for the chromatography community. From 6 to 10 September 2026, the city will host the </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/644"><strong>35th International Symposium on Chromatography – ISC 2026</strong></a><strong>, one of the leading international events dedicated to chromatography, separation science, and analytical chemistry.</strong></p><p><strong>Shimadzu</strong> is proud to support this prestigious event as a <strong>Platinum Sponsor</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ISC_2026_Shimadzu_as_a_platinum_sponsor_mensi_8c9f3eb6e7.jpg" alt="ISC 2026: Platinum sponsor Shimadzu" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ISC_2026_Shimadzu_as_a_platinum_sponsor_mensi_8c9f3eb6e7.jpg 235w," sizes="100vw" width="1600" height="1066"></p><p>ISC 2026 represents a unique opportunity for scientists, researchers, industry experts, application specialists, and technology providers to meet, exchange knowledge, and discuss the latest developments in chromatography and separation science. The conference will bring together experts from academia, pharmaceutical industry, environmental analysis, food safety, healthcare, life sciences, and many other fields where analytical technologies play an essential role.</p><p>We would like to warmly invite our <strong>customers, partners, colleagues</strong>, and the wider <strong>scientific community</strong> to join us at ISC 2026 in Prague. The conference will offer an inspiring scientific programme, lectures by internationally recognised experts, dedicated sessions on current trends and challenges, an exhibition area, and valuable opportunities for networking with the global chromatography community.</p><p>Following the successful <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/642"><strong>ISC 2024 in Liverpool</strong></a>, ISC 2026 will bring this important international symposium to the heart of Europe. We are looking forward to meeting you in Prague and contributing together to a strong and successful edition of ISC.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/1728218963766_9d5394a9da.jpg" alt="Gesa Schad: Shimadzu at ISC 2024 in Liverpool" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_1728218963766_9d5394a9da.jpg 156w," sizes="100vw" width="1280" height="1280"></p><p><strong>Visit </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/1371"><strong>Shimadzu at ISC 2026</strong></a><strong> in Prague and be part of one of the key international events in chromatography and separation science.</strong></p><blockquote><p class="cke-user_style-important">Registration is open on the official conference website:<br><a target="_blank" rel="noopener noreferrer" href="https://www.isc2026.org"><strong>www.isc2026.org</strong></a></p></blockquote><h3><strong>Shimadzu Vendor Seminar: Three New Reasons to Rethink Your Workflow</strong></h3><ul><li>07 September 2026</li><li>12 PM - &nbsp;13 PM</li></ul><p>Join us for an engaging seminar introducing three new analytical solutions designed to help laboratories work smarter, respond faster, improve robustness, and achieve greater confidence in their results. As analytical demands continue to grow, laboratories need technologies that not only deliver strong performance, but also enhance efficiency, flexibility, and ease of operation. This seminar will highlight how our <strong>latest innovations in IC, UHPLC, and GC-MS/MS</strong> can streamline workflows, support complex applications, and create new opportunities for productivity across your laboratory.</p><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=nexera+ic"><strong>Nexera IC</strong></a><strong> – New compact ion chromatography solution for reliable, high-sensitivity anion and cation analysis.</strong></h5><ul><li>Dr. Gesa Schad</li></ul><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=nexera+x4"><strong>Nexera X4</strong></a><strong> – Next-generation UHPLC platform designed for ultra-high performance and robust operation without compromise.</strong></h5><ul><li>Dr. Gesa Schad</li></ul><h5><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c146_e517_16e9bfd835.pdf"><strong>GCMS-TQ RX Series</strong></a><strong> – Advanced triple quadrupole GC-MS/MS systems engineered for enhanced sensitivity and dependable trace-level analysis.</strong></h5><ul><li>Dr. Waldemar Weber</li></ul><blockquote><p class="cke-user_style-important"><a target="_blank" rel="noopener noreferrer" href="https://www.shimadzu.eu/forms/vendor-seminar-registartion_isc2026.html"><strong>Register here</strong> <strong>to attend Shimadzu Vendor Seminar</strong></a></p></blockquote><h3><strong>Scientific Programme Presentation</strong></h3><ul><li>08 September 2026</li><li>10:30 – 12:00</li><li>Fun 5: Separations with Supercritical and Subcritical Fluids&nbsp;</li></ul><h5><strong>Accelerating Forensic Analysis: A Rapid SFC-MS Workflow for Novel Regioisomeric Fluorofentanyl Derivatives and Related Compounds</strong></h5><ul><li>Dr. Jennifer Field, Shimadzu UK, Milton Keynes, UK</li></ul><h3><strong>Winners of the Shimadzu student sponsorship</strong></h3><p>We are thrilled to announce the winners of the <strong>Shimadzu student sponsorship</strong> for <strong>free tickets to attend the ISC 2026</strong> conference. We received a great number of high-quality abstracts, showcasing the innovative research being conducted by students all over Europe.</p><p>We extend our heartfelt congratulations to all the winners and look forward to their contributions at the conference. To those who were not selected this time, we encourage you to continue your excellent work and apply again in the future.</p><p><strong>And the lucky winners are: &nbsp; &nbsp;</strong></p><h5><strong>Chromatography supports electrochemistry–mass spectrometry (EC-MS) analysis of olaparib and inavolisib metabolites</strong></h5><ul><li><strong>Fabiola Dontsi Tonleu</strong>, University of Münster, Germany&nbsp;</li><li><strong>Abstract ID:</strong> ISC-0262 &nbsp; &nbsp;</li></ul><h5><strong>Towards circular wind energy: Sample preparation strategies in combination with GC×GC-TOFMS for the characterization of wind turbine blade recycling products&nbsp;</strong></h5><ul><li><strong>Giulia Giacoppo</strong>, University of Ferrara, Italy</li><li><strong>Abstract ID:</strong> ISC-0169 &nbsp; &nbsp;</li></ul><h5><strong>Implementing SFC for analysis of antibiotics in manure</strong></h5><ul><li><strong>Michelle Hussock</strong>, University of Duisburg-Essen, Germany</li><li><strong>Abstract ID:</strong> ISC-0220 &nbsp;</li></ul><h5><strong>Identifying optimal LC-MS conditions for oligonucleotide mapping of mRNA: A multi-criteria assessment of methods</strong></h5><ul><li><strong>Athanasios Tsalmpouris</strong>, University of Geneva, Switzerland</li><li><strong>Abstract ID:</strong> ISC-0211</li></ul><h5><strong>From weeds to crop protectants: phytochemical profiling and dual biopesticidal activities of Chenopodium ambrosioides and Cleome gynandra &nbsp;</strong></h5><ul><li><strong>Rahim Ullah</strong>, University of Helsinki, Finland</li><li><strong>Abstract ID:</strong> ISC-0249 &nbsp;</li></ul><h4><strong>Poster Presentations</strong></h4><h5><strong>Optimal column selection for experimental surface polarity measurement using supercritical fluid chromatography</strong></h5><ul><li>Yoshiyuki Watabe, Shimadzu Corporation, Kyoto, Japan</li><li><strong>Session:</strong> BIO08 - Sample preparation and automation</li></ul><h5><strong>Characterization of SFC stationary phases for Analysis of Essential Oils</strong></h5><ul><li>Martin Meyer, Shimadzu Europa, Duisburg, Germany</li></ul><h5><strong>High-sensitivity analysis of more than 100 pesticides in food using microflow LC-MS/MS</strong></h5><ul><li>Ramy Abou Naccoul, Shimadzu France, Marne la Vallée, France</li><li><strong>Session:</strong> HYP05 - Microfluidic and chip separations in MS</li></ul><h5><strong>Streamlined selection of optimal separation conditions using an automated LC/SFC method development platform</strong></h5><ul><li>Dr. Gesa Schad, Shimadzu Europa, Duisburg, Germany</li><li><strong>Session: </strong>FUN05 - Separations with super - and sub-critical fluids</li></ul><h5><strong>Ion Chromatographic Determination of Major Inorganic Ions in Beer for Quality Control and Product Differentiation</strong></h5><ul><li>Dr. Vadim Kraft, Shimadzu Europa, Duisburg, Germany</li><li><strong>Session:</strong> FUN08 - Separation modes</li></ul><h5><strong>Efficient SFC Method Development for the Analysis of Essential Oils Using Shimadzu LabSolutions MD</strong></h5><ul><li>Dr. Brigitte Bollig, Shimadzu Europa, Duisburg, Germany</li><li><strong>Session:</strong> HYP02 - SFC-MS</li></ul><h5><strong>Assessing the applicability of retention modelling as a tool for oligonucleotide analysis using ion-pair HPLC</strong></h5><ul><li>Richard Hodgson, Shimadzu UK, Milton Keynes, UK</li></ul><h3><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/7477"><strong>ISC 2026 Scientific program</strong></a><strong> highlights</strong></h3><p>The programme runs across three parallel tracks — Fundamentals, Bioanalysis &amp; Omics Applications, and Hyphenation Techniques — covering topics from column technology, chiral and multi-dimensional separations, and AI/machine learning in separation science, to proteomics, green analytical chemistry, and LC/MS data processing.</p><h4><strong>Why it matters for industry</strong></h4><p>This year's Industry Program is shaping up particularly well, giving companies a direct space to connect with academia and the next generation of scientists:</p><ul><li><strong>Industry &amp; Education</strong> – bridging academic training with industry needs</li><li><strong>Career Presentation</strong> – companies showcase career paths and hiring needs to students and professionals</li><li><strong>AI in Separation Science </strong>– real-world use of AI in method development and lab workflows</li><li><strong>Sustainability in Separation Science</strong> – translating green chemistry research into industrial practice</li></ul>

Shimadzu to Join ISC 2026 in Prague as Platinum Sponsor

<p><strong>High-performance polymers provide unparalleled chemical and thermal resistance, making them ideal for a wide variety of challenging applications in the fields of aerospace and semiconductor fabrication. This resilience poses a challenge for analytical research, further complicated by a significant variety of formulations, including a wide range of additives.</strong></p><p>Recently, the chemists at LECO took on the challenge of characterizing the chemical makeup of a high-performance polymer known as polyphenylene sulfide, or PPS. PPS is a thermoplastic with a semi-crystalline structure, engineered for high heat and chemical resistance. The scientists used two complementary analytical techniques to unravel this complex and challenging sample: <strong>thermal desorption and pyrolysis</strong>.</p><h3><strong>Thermal Desorption and Pyrolysis: Complementary Analytical Techniques</strong></h3><p><strong>Thermal desorption</strong> involves controlled heating of a sample up to 300 degrees Celsius, allowing for the gradual volatilization of key analytes within the sample, ideally without damaging their chemical structure.&nbsp;<br><strong>Pyrolysis</strong> uses much more intense heat, ranging from 600 degrees Celsius and beyond. Rather than focusing on the preservation of volatiles, pyrolysis allows for the analysis of less volatile polymers by splitting these long chains into more easily analyzed segments.&nbsp;</p><p>By performing both methods, the full chemical composition can be revealed: additives and contaminants through thermal desorption, and base polymer structure via pyrolysis. Using only one of the methods would result in an incomplete picture of the polymer, making the analysis much less valuable and leaving gaps in the results.</p><p>This two-pronged analytical approach allows for a more complete analysis of complex and challenging polymers without the significant sample prep time of alternative methods such as dissolution or derivatization. With thermal desorption and pyrolysis, you get the output you need, minus the long wait.</p><h3><strong>Analysis: Why 1D GC Isn’t Enough</strong></h3><p>While thermal desorption and pyrolysis made it possible to analyze the PPS using gas chromatography, analysis of this high-performance polymer necessitates the utilization of equally high-performance analytical instrumentation in order to achieve thorough, trustworthy insights. LECO chemists ran the sample using both GC-TOFMS (gas chromatography time-of-flight mass spectrometry) and GCxGC-HRTOFMS (two-dimensional gas chromatography with high-resolution time-of-flight mass spectrometry), and the differences were noteworthy.</p><p>Multidimensional chromatography resulted in excellent separation of coeluting compounds from the first-dimension separation. The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/39"><strong>Pegasus HRT+4D </strong></a>produced cleaner spectra and delivered more compound annotations when compared to 1D GC-HRMS analysis.</p><h3><strong>The Importance of Confident Results</strong></h3><p>Analysis of high-performance polymers is critical to ensure product quality and safety. Since polymers are often used in environments where performance isn’t just expected, but mission-critical, it’s imperative that they perform as intended. Beyond quality control, effective analysis of these polymers allows for the optimization of current industrial processes, as well as the development of better high-performance polymers and manufacturing processes.</p><ul><li>For a closer look at the research and a more detailed description of the process, watch our webinar, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6039"><strong>“Characterization of High-Performance Polymers Using Thermal Desorption/Pyrolysis and High-Resolution Mass Spectrometry”</strong></a></li><li>To learn more about LECO’s work with high-performance materials, check out our <a target="_blank" rel="noopener noreferrer" href="https://www.leco.com/applications/high-performance-materials/"><strong>High-Performance Materials Resource Hub</strong></a></li></ul>

 Solving the Challenge of High-Performance Polymer Analysis with GCxGC-HRTOFMS

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 3rd August 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies </strong>and<strong> Shimadzu </strong>and presentation by<strong> MDCW / University of Alberta!</strong></p><h3><strong>1. Agilent Technologies: Analysis of Trace Impurities in Monocyclic Aromatic Solvents Following ASTM D7504</strong></h3><p><strong>Dual simultaneous analysis using the Agilent 8860B gas chromatograph</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_trace_impurity_aromatic_solvents_analysis_astm_d7504_8860_gc_5994_9316en_agilent_c9fa6868e6.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>The production of high-purity monocyclic aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), is a cornerstone of the modern petrochemical industry. These compounds serve as essential feedstocks for the synthesis of plastics, resins, and textiles. Because even trace impurities can adversely affect downstream chemical reactions and product quality, rigorous analytical testing is required to ensure these intermediates meet strict commercial specifications.&nbsp;</p><p>ASTM D7504 is the industry-standard test method for determining the purity of, and trace impurities in, monocyclic aromatic hydrocarbons using gas chromatography (GC) with flame ionization detector (FID).1 This method is favored for its streamlined workflow; it utilizes effective carbon number (ECN) correction factors for area normalization. This eliminates the need for labor-intensive, multipoint calibrations for every individual impurity, allowing laboratories to calculate purity and quantify trace nonaromatics and aromatics with high precision.&nbsp;</p><p>The application scope of ASTM D7504 covers a wide array of aromatic liquids, including benzene, toluene, mixed xylenes, and styrene. To comply with the method's stringent performance requirements, the GC system must&nbsp;demonstrate:&nbsp;</p><ul><li><strong>High sensitivity: </strong>A limit of quantitation (LOQ) of at least 0.0006% by mass.</li><li><strong>Good resolution: </strong>Maintaining a valley-to-peak ratio of no more than 50% for critical separations (such as p-xylene and m-xylene).&nbsp;</li><li><strong>Strict precision: </strong>Highly reproducible peak areas to ensure accurate purity calculations.</li></ul><p>Implementing ASTM D7504 on a dual-channel GC/FID platform—where two independent analytical channels configured with identical injectors, columns, and detectors operate within a single GC oven—provides significant operational advantages:&nbsp;</p><ol><li>Enhanced laboratory throughput: By performing two injections simultaneously, the test lab can double its sample capacity per instrument, effectively reducing the cost-per-analysis and maximizing hardware ROI.&nbsp;</li><li>Method flexibility and redundancy: A dual-channel set up allows a lab to run different sample types (such as toluene on the front channel and xylene on the back) in a single oven cycle. Furthermore, it provides an immediate "back up" channel to maintain uptime during routine&nbsp;maintenance.&nbsp;</li></ol><p>For the system to be considered reliable, both channels should meet ASTM D7504 sensitivity, resolution, and precision requirements. In addition, both channels should yield consistent quantitative results for the same sample. The reproducibility limit (R) demonstrated in ASTM D7504 interlaboratory testing will be used to evaluate the result consistency between the two channels.</p><p>ASTM D7504 recommends helium and hydrogen as carrier gas. In China, major Chinese petrochemical companies often align their internal quality control standards directly with ASTM D7504 when testing for export of high-purity chemical intermediates. Because nitrogen is commonly used in China, they commonly adapt the ASTM D7504 method to use nitrogen carrier gas.&nbsp;</p><p>This application note demonstrates how dual-channel analysis on the Agilent 8860B GC, following ASTM D7504, delivers consistent and high-precision data using three types of carrier gas.</p><h4><strong>Experimental</strong></h4><p>An <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8860B"><strong>Agilent 8860B GC</strong></a><strong> </strong>was configured with dual split/splitless inlets and dual flame ionization detectors (FIDs). The sample introduction was made by dual <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7693A"><strong>Agilent 7693A automatic liquid samplers (ALS)</strong></a> with high density turrets (16-vial). The analytical parameters and consumables are summarized in Tables 1 and 2. Data acquisition and analysis were conducted using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=OpenLab+CDS"><strong>Agilent OpenLab CDS version 2.8</strong></a></p><h4><strong>Conclusion&nbsp;</strong></h4><p>The Agilent 8860B gas chromatography system configured with two identical analytical channels are applied for impurity analysis in monocyclic aromatic solvents using three carrier gases. Each analytical channel was evaluated according to the ASTM D7504 method in terms of resolution, sensitivity, quantitation precision, and recovery with satisfactory results. The quantitation results between the two channels are consistent with each other.&nbsp;</p><ul><li>Column resolution compounds pair demonstrated good separation with H/V no less than 5:1 for 300 ppm m-xylene and p-xylene solvent.&nbsp;</li><li>The LODs achieved for benzene on each analytical channel are less than 0.0001%, exceeding the 0.0002% LOD required by ASTM D7504.&nbsp;</li><li>The response and mass concentration precisions of most impurities in check standards are below 1%, meeting or exceeding the precision requirements in D7504.&nbsp;</li><li>Excellent recovery results, ranging from 93 to 105%, was achieved for added impurities, indicating good quantification accuracy based on the 8860B GC system.&nbsp;</li><li>The quantitation difference of all probe impurities between two channels is less than the reproducibility thresholds (R), demonstrating excellent across channel consistency</li></ul><p>Besides great instrument performance, the Agilent OpenLab CDS software can realize ECN based normalization for easy and fast quantitation and report generation. The 8860B dual channel GC system coupled with the OpenLab CDS software provides an accurate and reliable analysis of impurities in monocyclic aromatic solvents with satisfactory precision. Lab productivity can be improved significantly compared to the single channel analytical system.</p><h3><strong>2. MDCW / University of Alberta: Leveraging Local Libraries for Positively Parsimonious Peak Tables</strong></h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_6_Harynuk_f005bdafaf.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>James J. Harynuk’s presentation, <strong>“Leveraging Local Libraries for Positively Parsimonious Peak Tables,”</strong> explores how custom mass spectral libraries can simplify and improve compound identification in complex GC×GC-(HR)MS datasets. GC×GC-MS is widely applied in petroleum, environmental, food/flavour, and omics research, where samples can contain hundreds or thousands of peaks. While expanded separation space, cleaner spectra, retention patterns, and high-resolution accurate-mass data provide strong identification capabilities, converting large datasets into coherent peak tables with consistent compound assignments across multiple samples remains challenging.</p><p>The presentation demonstrates the approach using a field pea study investigating how nitrogen availability influences plant metabolism and volatile organic compounds. A conventional workflow based on peak finding and library searching can generate very large peak tables and inconsistent assignments. Incorporating retention indices (RI) and LECO’s Identification Grading System (IGS) substantially reduces the number of questionable peaks. In one example, a pea sample containing <strong>789 detected peaks was reduced to 146 retained peaks</strong> after RI filtering and IGS scoring, producing a much more manageable dataset. However, conventional libraries still struggle with isomers and with compounds that repeatedly occur in a laboratory’s samples but cannot yet be confidently identified—the presentation calls these <strong>“unknown knowns.”</strong></p><p>Harynuk therefore proposes building a <strong>custom local HRMS library</strong> containing not only standards and confidently identified compounds, but also reproducible unknown features. To qualify for inclusion, a peak should have a high-quality spectrum, S/N &gt;100, chromatographic purity, occurrence in multiple technical replicates, an assigned retention index, and a unique identifier. Crucially, the exact chemical identity does not need to be known: an unknown but reproducible feature can receive an internal identifier such as “JJH-001” and be updated later as more information becomes available. This allows laboratories to retain analytically meaningful recurring signals instead of discarding them simply because a definitive library identification is unavailable.</p><p>The results show that combining a custom library with local RI data and IGS filtering improves both the consistency and efficiency of peak-table generation. Compounds with IGS scores ≥3.0 were generally assigned the same identification across samples when the custom library was used, while reliance on NIST and IGS alone produced less consistent results. After correcting only a small number of problematic identifications per peak table, retention-index errors for custom-library entries dropped dramatically—in the evaluated samples, typically to around <strong>0.5–1.9 RI units</strong>. The key recommendation is therefore straightforward: <strong>build a custom MS library, include recurring “unknown knowns,” collect local retention-index data, and apply identification-quality filters</strong> to obtain cleaner and more consistent GC×GC-MS peak tables with substantially less manual effort.</p><h3><strong>3. Shimadzu: Simultaneous Analysis of Pesticide Residues in Food Using Triple Quadrupole GC-MS/MS with SPL Mode of a Multimode injection Unit (MMI)</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01234_en_d8cff47c74.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>User benefits</strong></h4><ul><li>The MMI’s rapid heating and cooling technology significantly reduces waiting time during inlet maintenance, improving instrument uptime.&nbsp;</li><li>The Smart Pesticides Database enables automatic creation of analytical methods without the need for pesticide standards.&nbsp;</li><li>Peakintelligence for GCMS uses AI-based peak processing to deliver highly accurate analysis with no parameter settings required</li></ul><p>GC-MS/MS is an indispensable tool for the simultaneous analysis of pesticide residues in food. However, improving productivity in high-throughput workflows remains a persistent challenge. With the increasing use of simplified sample preparation methods such as QuEChERS, contamination of the inlet by matrix components is unavoidable, and frequent inlet maintenance, including liner replacement, is often required. Because this maintenance involves both cooling the inlet and waiting for temperature re-stabilization afterward, it can become a major source of instrument downtime.&nbsp;</p><p>The newly developed Multi-Mode Inlet (MMI) incorporates Shimadzu’s proprietary thermal insulation technology, providing excellent temperature stability together with rapid heating and cooling performance. While maintaining high data compatibility with conventional split/splitless inlets, the MMI significantly reduces the waiting time associated with inlet maintenance.</p><p>In this Application News, simultaneous multiresidue analysis in SPL mode is demonstrated for four food matrices with different characteristics - spinach, orange, avocado, and ginger - using the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-TQ+8040+RX"><strong>GCMS-TQ 8040 RX triple quadrupole</strong> </a>GC-MS/MS equipped with the MMI.</p><h4><strong>Data Analysis&nbsp;</strong></h4><p>LabSolutions Insight, a quantitative data processing software package designed for high-throughput sample analysis, was used for data analysis, with Peakintelligence for GCMS applied as the peak integration algorithm (Fig. 6). Peakintelligence is an AI-based waveform processing algorithm that uses machine learning to emulate the peak processing performed by experienced analysts. It requires no operator-defined parameter settings and provides peak integration performance comparable to that of skilled users.&nbsp;</p><p>For more information on improving the efficiency of pesticide data analysis using Peakintelligence for GCMS, please refer to Application News 01-00585-EN, “<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00585_en_7e311a3c77/an_01-00585-en.pdf"><strong>Time-Saving Data Processing for Pesticide Residues with Peakintelligence for GCMS</strong></a>.”</p><h4><strong>Conclusion&nbsp;</strong></h4><p>In this Application News, an example of simultaneous multiresidue pesticide analysis in food using a triple quadrupole GC-MS/MS equipped with a Multi-Mode Inlet (MMI) was presented. By adopting the MMI, instrument downtime associated with inlet maintenance can be significantly reduced while maintaining high quantitative performance. In addition, by combining automated method creation with the Smart Pesticides Database and efficient data analysis using the AIbased waveform processing algorithm Peakintelligence for GCMS, highly accurate results were obtained even for complex food matrices. This system optimizes the overall analytical workflow, from method development and maintenance to data analysis, and can make a substantial contribution to improving productivity in high-throughput pesticide residue analysis.</p></div></div></div></div></div></div></section></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 32, 2026

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In 1936, the Laboratory Equipment Company introduced the first rapid carbon determinator for the American iron and steel industry.  Today, almost 80 years later, LECO is recognized globally as a leader in the development of high-quality analytical instrumentation, mass spectrometers, comprehensive two-dimensional chromatography, metallography & optical equipment as well as consumables.

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News from LabRulezGCMS Library - Week 32, 2026

Shimadzu to Join ISC 2026 in Prague as Platinum Sponsor

Solving the Challenge of High-Performance Polymer Analysis with GCxGC-HRTOFMS