Blowdown evaporation is a common sample preparation step used by analytical laboratories to dry down or concentrate their test samples. Dry gas is continuously blown onto the sample's surface, sometimes in conjunction with heat, to speed up the evaporation of excess solvent and further concentrate the sample prior to analytical techniques such as <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-gc-ms/ms-analysis">GC-MS</a> or <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-hplc-ms/ms-analysis">HPLC</a>. Nitrogen gas is most commonly used during <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=e9dbWmoWwSw">blowdown evaporation</a> as it provides the fastest evaporation rates, and is a proven safe drying media that poses minimal risk to the analysis.Dry nitrogen is considered an inert gas, which means that it is chemically inactive. Unlike compressed air that contains oxygen and water vapor that could react with the compounds in the test sample, pure, dry nitrogen will not deteriorate the sample in any way.High purity nitrogen is able to delay or prevent oxidation that could occur throughout the drying process. Depending on the solvents and solutes contained in the test sample, a chemical reaction could occur with a relatively small exposure to oxygen. Drying that sample down with compressed air which contains a fair amount of oxygen, will not only speed up the oxidation process, but also make your final analysis unreliable.What's even more important than keeping the samples safe, is keeping the lab technicians safe during the entire evaporation process. Since nitrogen is a non-reactive gas, it's also non-flammable and will not increase the risk of an chemical combustion. This is especially important when working with any flammable or otherwise reactive solvents such as carbon disulfide and diethyl ether.Not only is nitrogen gas the most reliable drying media, but it is also proven to have the fastest evaporation rate. Studies have shown that evaporation rate is dependent on the humidity of the atmosphere in which the samples are in. The more steps that can be taken to reduce the humidity, the faster the concentration rate will be. These same studies have shown that the most effective way to reduce the humidity is by purging the atmosphere with nitrogen, aka nitrogen blowdown evaporation.Faster concentration rates lead to a reduction in contamination and degradation risks by minimizing the amount of time the samples spend in the atmosphere. The use of nitrogen gas in blowdown evaporation provides labs with the most dependable samples to analyze in the quickest amount of time. It's a win-win.Another win is that nitrogen gas is a far more affordable alternative to other inert gasses such helium or argon. This is especially true with the use of a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1902">nitrogen generator</a>, which can provide an endless supply of high-purity nitrogen for your laboratory. With minimal maintenance and virtually no waste, you can feel good knowing you're utilizing an <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/are-nitrogen-generators-actually-more-environmentally-friendly">eco-friendly nitrogen generation solution</a>.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_NITRO_GEN_Nitrogen_Generator_1cce90a981.webp" alt="Organomation: Why Nitrogen is Ideal for Drying Samples: Organomation NITRO-GEN Nitrogen Generator." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_NITRO_GEN_Nitrogen_Generator_1cce90a981.webp 156w," sizes="100vw" width="1400" height="1400">Learn the most <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/nitrogen-generation-options-for-laboratory-use">common nitrogen generation options for laboratory use</a>, and discover the solution that best fits your needs. For more information on nitrogen generators, check out this comprehensive guide: <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/nitrogen-generators-everything-you-need-to-know">Nitrogen Generators: Everything You Need to Know</a>.

Why Nitrogen is Ideal for Drying Samples

Many industries rely on a nitrogen blowdown evaporator as a key step in processing their samples. These industries include environmental testing, agriculture, food and beverage, medicine, quality assurance, forensics, oil and grease, and many more. So, what exactly is it?A nitrogen blowdown evaporator is a key piece of lab equipment that is used to prepare samples for <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/chromatography-sample-preparation-guide">chromatography</a>, <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/mass-spectrometry-sample-preparation-guide">mass spectrometry</a> or other analysis by removing excess solvent. The process works by lowering the vapor pressure above the sample, allowing excess solvent to evaporate more quickly. This method of concentration is especially effective for small volume samples in volatile or semi-volatile organic solvents. The precision of nitrogen blowdown makes it a great choice for those who are looking to evaporate to complete dryness or stop at a specific endpoint.Compared to a heated sample, solvent molecules in a sample under ambient conditions are very low energy and therefore slow-moving. Due to this lack of speed, only some molecules can be vaporized and separated from the sample. Combined with the vapor pressure above the sample this causes many molecules to return, slowing down evaporation. This is where nitrogen blowdown evaporation is a useful tool. The evaporator works by applying a steady stream of nitrogen gas just above the surface of the sample, which gently pushes the vapor-saturated air out, preventing it from returning to the remaining liquid.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_What_is_Nitrogen_Blowdown_Evaporation_2_64a8e42723.jpg" alt="Organomation: What is Nitrogen Blowdown Evaporation?" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_What_is_Nitrogen_Blowdown_Evaporation_2_64a8e42723.jpg 245w," sizes="100vw" width="827" height="398">The nitrogen gas cools the sample slightly, which decreases the energy of the molecules and slows them down, diminishing their ability to vaporize. To speed the molecules back up, heat can be applied in the form of a water bath or dry block in order to reenergize the sample. The combination of nitrogen blowdown and heat quickly vaporizes the molecules, leaving a perfectly evaporated sample behind. If you are using a water bath, it should be set to a few degrees lower than the boiling point of your sample in order to achieve maximum concentration. On average, it takes only twenty-five minutes to safely concentrate a 10mL sample of methylene chloride using a nitrogen blowdown evaporator. This is compared to <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/how-much-time-is-wasted-preparing-individual-sample-vials-infographic">evaporating samples by hand</a>, which can be a time-consuming process. For a few samples this can be justifiable, but for regular use, evaporation by hand is an inefficient process.Nitrogen blowdown is gentle on the sample and does not require any consumables, making it an affordable and safe choice. We offer three product lines of nitrogen blowdown evaporators – the most-popular N-EVAP and its counterparts, MULTIVAP, and MICROVAP. You can <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-differences-between-organomations-blowdown-evaporators">learn more</a> about the differences between these products, and use our quick <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/support/contact-help-support/sample-evaporator-product-finder">product finder</a> to figure out which one is the best fit for your needs.Nitrogen can be expensive to purchase and inconvenient to store. We are proud to make a lightweight and portable <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/enhance-your-sample-preparation-with-a-nitrogen-gas-generator">nitrogen gas generator</a>, called the NITRO-GEN. It is the perfect solution for any laboratory looking for a low-cost solution to integrate with an existing clean air line. It also boasts a reduction in your carbon footprint, removing the emissions of transporting nitrogen cylinders to and from your lab.<blockquote>For more information on nitrogen blowdown evaporation or on any of our products, reach out to our team at <a href="mailto:sales@organomation.com">sales@organomation.com</a> or use our <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/#hs-chat-open">live chat</a> during normal business hours.</blockquote>

What is Nitrogen Blowdown Evaporation?

In the world of analytical chemistry, the focus often falls on cutting-edge instrumentation and groundbreaking analytical techniques. However, a crucial yet frequently overlooked aspect of the analytical process is sample preparation. Recent research into university laboratory practices and costs reveals that sample preparation is not only time-consuming but also represents a significant portion of analytical expenses. This article delves into the importance of efficient sample preparation and how tools like Organomation's blowdown evaporators can revolutionize laboratory workflows.<h3>The True Cost of Sample Preparation</h3>To understand the value of sample preparation time, we took a look at what an average American university lab charges for their sample preparation services. Our findings from the University of Kansas paint a clear picture of the resources dedicated to this critical step:<ol><li>&nbsp;Sample Preparation Charges:</li></ol><ul><li>Internal Users are charged $76 per sample</li><li>External Users are charged $118 per sample</li></ul><ol start="2"><li>Analytical Instrumentation Time:</li></ol><ul><li>Internal Users are charged $30 per hour</li><li>External Users are charged $47 per hour</li></ul>These figures demonstrate that sample preparation costs are comparable to, and in some cases exceed, the hourly rates for using advanced analytical instruments. This underscores the significant value placed on sample preparation by research institutions.<h3>Time: The Hidden Resource</h3>Beyond monetary costs, time is perhaps the most critical resource in laboratory settings. Our research indicates that sample preparation typically consumes over two-thirds of the total analysis time in many analytical procedures. This disproportionate time allocation can create <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/is-removing-solvent-from-test-tubes-slowing-your-research">bottlenecks in research workflows</a>, potentially delaying important discoveries and slowing down scientific progress.<h3>The Ripple Effect of Inefficient Sample Preparation</h3>Inefficient sample preparation techniques, such as<a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/how-much-time-is-wasted-preparing-individual-sample-vials-infographic"> drying down sample vials one at a time</a>, can have far-reaching consequences:<ol><li>Reduced sample throughput</li><li>Increased risk of sample contamination or loss</li><li>Greater variability in results due to inconsistent preparation methods</li><li>Less time available for data analysis and interpretation</li><li>Delayed publication of research findings</li></ol><h3>Transforming Workflows with Efficient Sample Preparation</h3>Investing in efficient sample preparation techniques, such as <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=362&amp;instrumentationItems=10&amp;manufacturerItems=540">Organomation's blowdown evaporators</a>, can yield significant benefits:<ul><li>Time Savings: Simultaneous processing of multiple samples dramatically reduces overall preparation time.</li><li>Improved Consistency: Automated systems ensure uniform treatment of all samples, enhancing reproducibility.</li><li>Resource Optimization: Researchers can reallocate saved time to higher-value activities such as data analysis or method development.</li><li>Cost-Effectiveness: While there's an initial investment, efficient preparation techniques can lead to long-term cost savings through increased productivity.</li><li>Enhanced Research Quality: More time for careful analysis and interpretation can lead to more robust and impactful research outcomes.</li></ul><h3> Case Study: University of Cincinnati's Transition to Automated Sample Drying</h3>The Department of Chemical &amp; Environmental Engineering at the University of Cincinnati faced a common challenge in their analysis of environmental samples for organic pollutants: the need for <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/manual-to-automated-solvent-drying-is-it-worth-the-switch">efficient sample concentration prior to LC-MS analysis</a>. Their workflow involved processing batches of 10 samples, each containing 5 mL of methanol or acetonitrile that needed to be evaporated to complete dryness.<h4>The Challenge</h4>Initially, the lab relied on a makeshift evaporation setup in their fume hood due to budget constraints. This manual method had several drawbacks:<ul><li>It took over 2 hours to dry down each sample, and not to complete dryness.</li><li>Only one sample could be processed at a time, creating a significant bottleneck.</li><li>The process lacked precision and control, potentially affecting result consistency.</li></ul><h4>The Solution: Organomation's N-EVAP Nitrogen Evaporator</h4>With some end-of-year budget available, the lab invested in a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1908">12-position N-EVAP nitrogen evaporator from Organomation</a>. This decision led to immediate and substantial improvements:<ul><li>Dramatic Time Savings: Evaporation time was reduced from over 20 hours for a batch of 10 samples to just 1 hour - a 20x improvement in efficiency.</li><li>Increased Capacity: The ability to process up to 12 samples simultaneously eliminated the previous bottleneck.</li><li>Enhanced Precision: Individual adjustment of flow rate and needle height for each sample allowed for consistent and controlled evaporation.</li><li>Improved Results: The N-EVAP achieved complete dryness, enhancing the accuracy of low-concentration analyte detection.</li><li>Ease of Use: The system's simple design and unattended operation streamlined the process, reducing manual intervention and potential errors.</li></ul><h4>Key Factors in Efficiency Improvement</h4>The dramatic increase in efficiency was attributed to several factors:<ul><li>Batch Processing: The ability to evaporate multiple samples simultaneously.</li><li>Controlled Heating: Introduction of a gentle water bath (35°C) significantly increased evaporation rates.</li><li>Switch to Nitrogen Gas: Replacing compressed air with nitrogen resulted in approximately 10% faster evaporation.</li></ul>This case study demonstrates how transitioning from manual to automated sample drying can significantly enhance laboratory efficiency, particularly in academic settings where resources are often limited. The investment in appropriate equipment not only saved time but also improved the quality and consistency of research outcomes.<h3>Calculate Your Potential Time Savings</h3>To help researchers quantify the potential benefits of upgrading their sample preparation methods, Organomation offers a free, easy-to-use Evaporation Time Calculator. This valuable tool allows you to estimate how much time you could save by using an Organomation nitrogen evaporator instead of your current sample concentration procedure.Using the calculator is simple:<ol><li>Visit <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/evaporation-time-calculator">https://www.organomation.com/evaporation-time-calculator</a></li><li>Enter your starting sample volume</li><li>Input your desired ending volume</li><li>Select the solvent you're removing</li></ol>Within just one minute of submitting this information, you'll receive a customized estimate of your potential time savings. This instant feedback can help you make informed decisions about optimizing your laboratory's workflow.We encourage all researchers to take advantage of this free tool. By seeing concrete numbers specific to your procedures, you can better understand the impact that efficient sample preparation techniques could have on your research productivity. Whether you're dealing with a handful of samples or managing high-throughput operations, the potential time savings could be substantial.<h3>The Value of Time in Analytical Chemistry</h3>Our research clearly demonstrates that sample preparation time is a valuable commodity in analytical chemistry. By adopting efficient preparation techniques, laboratories can:<ol><li>Increase sample throughput</li><li>Improve result consistency and reliability</li><li>Allocate more time to critical thinking and analysis</li><li>Potentially reduce overall costs</li><li>Accelerate the pace of scientific discovery</li></ol>As analytical chemistry continues to advance, it's crucial not to overlook the foundational steps of the process. Investing in efficient sample preparation techniques, such as Organomation's blowdown evaporators, can unlock new levels of productivity and innovation in laboratory settings.By recognizing the true value of sample preparation time and taking steps to optimize this process, researchers can ensure they're making the most of their resources and pushing the boundaries of scientific discovery. Remember, in the world of analytical chemistry, time saved in sample preparation is time gained for critical thinking, data analysis, and advancing scientific knowledge. Take the first step towards optimizing your workflow by using Organomation's <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/evaporation-time-calculator">Evaporation Time Calculator today</a>.

How Ineffective Sample Preparation is Costing Academic Researchers

<h3>Determine if a Nitrogen Dryer is Faster Than Your Current Evaporation Method</h3>In laboratory workflows, sample preparation efficiency is critical to maintaining productivity and ensuring high-quality results. Evaporation is a key step in many analytical processes, from environmental testing to pharmaceutical research, yet it is often a bottleneck that slows down operations. If your current evaporation method is consuming too much time or yielding inconsistent results, it may be time to consider an alternative approach.Our Evaporation Time Calculator allows you to determine exactly how long it will take for your samples to dry down. By inputting basic information about your sample volume and solvent, you can receive an accurate time estimate and evaluate whether a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=3&amp;manufacturerItems=540">nitrogen evaporator</a> could enhance your lab’s workflow.<h4>Why Use an Evaporation Time Calculator?</h4>Evaporation time varies significantly depending on solvent properties, sample volume, and evaporation method. Many laboratories still rely on traditional methods such as air drying in the fume hood or <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/manual-to-automated-solvent-drying-is-it-worth-the-switch?hsLang=en">manually drying singular samples with a stream of nitrogen</a>. These methods can be quite inefficient and lead to extended wait times between analysis steps. This calculator helps you:<ul><li>Estimate Evaporation Time with Accuracy: Entering a few key details about your test samples allows you to get a precise estimate of drying time.</li><li>Evaluate Your Current Method: Compare how long your evaporation process takes using conventional techniques versus with a nitrogen evaporator.</li><li>Improve Lab Scheduling: Knowing the expected evaporation time allows for better planning of experiments, reducing downtime and increasing productivity.</li></ul><h4>How the Calculator Works</h4>Our Evaporation Time Calculator takes only 1 minutes to complete, requiring only the necessary inputs about your sample type:<ol><li>Starting Solvent Volume: Specify the initial amount of solvent in mL that you have in each sample</li><li>Ending Solvent Volume: Indicate how much solvent in mL should remain after evaporation. This allows the calculator to determine how much solvent needs to be evaporated off in total.</li><li>Solvent Type: Choose from a list of commonly used solvents, each of which has unique evaporation characteristics that influence drying time.</li></ol>Once you enter this information, the calculator determines how much solvent must be removed and estimates the total time required for evaporation based on the solvent's evaporation rate.<h4>Understanding Evaporation Time Variables</h4>Several factors affect how long it takes for a solvent to fully evaporate, including:<ul><li>Solvent Volatility: Some solvents, such as acetone or methanol, evaporate much faster than high-boiling-point solvents like dimethyl sulfoxide (DMSO).</li><li>Temperature &amp; Pressure Conditions: Higher temperatures and reduced pressure can accelerate evaporation, but not all labs have access to advanced heating or vacuum systems.</li><li>Evaporation Method: Passive evaporation or drying samples one at at time by hand can take significantly longer than methods using active nitrogen blowdown or heat-assisted drying.</li></ul><h4>Is a Nitrogen Evaporator Right for You?</h4>If the calculator reveals that your current evaporation process is taking longer than expected, switching to a nitrogen evaporator could drastically improve efficiency.<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392"> Nitrogen blowdown evaporation</a> is a well-established method that directs a controlled stream of nitrogen gas onto the surface of the solvent, promoting rapid and uniform evaporation while minimizing contamination risks.Key Benefits of Nitrogen EvaporationAccelerated Evaporation: Reduces sample drying time compared to passive evaporation or manual methods.<ul><li>Reliable &amp; Consistent Results: Ensures uniform solvent removal, preventing sample loss or variability.</li><li>Better Sample Protection: Prevents oxidation, contamination, and temperature fluctuations that could affect sample integrity.</li><li>Adaptability for Different Sample Types: Works with microplates, tubes, and flasks, making it suitable for various applications.</li><li>Space-Saving &amp; Cost-Effective: Many nitrogen evaporators are compact and require minimal maintenance compared to bulkier alternatives.</li></ul><h4>Optimize Your Lab’s Workflow Today</h4>Slow evaporation times can hinder productivity, delay experiments, and increase operational costs. With our Evaporation Time Calculator, you can gain valuable insights into your current process and determine whether a nitrogen evaporator is the right investment for your lab.Find out how long it takes to dry down your samples—and discover how faster, more <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/types-of-laboratory-evaporators?hsLang=en">efficient evaporation methods</a> can help you save time and improve results.

How long will it take to evaporate your samples in a nitrogen evaporator?

<h4>Is a Nitrogen Evaporator Faster than your Current Sample Concentration Method?</h4>In laboratory environments where sample preparation is a daily task, every minute counts. Whether you’re working in environmental testing, pharmaceuticals, food safety, or chemical analysis, sample evaporation is a necessary but often time-consuming step in your workflow.If your current evaporation method is slowing down your productivity—whether it’s <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/manual-to-automated-solvent-drying-is-it-worth-the-switch?hsLang=en">evaporating samples by hand</a>, air drying in a fume hood, <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/diy-evaporation-setups-vs.-professional-nitrogen-blowdown-systems-knowing-when-to-upgrade?hsLang=en">using a DIY setup</a>, or relying on an inefficient evaporator—you might be spending far more time than necessary on solvent removal.That’s where nitrogen evaporators come in. These systems use a steady stream of nitrogen gas and a gentle heat source to <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392">accelerate solvent evaporation</a>, offering a faster, more controlled, and more efficient solution than alternative methods. But just how much time could you save?<h3>Try Our Time-Saving Calculator</h3>To help you understand the potential efficiency gains, we’ve created a Nitrogen Evaporation Time-Saving Calculator. By inputting details about your current evaporation process, such as solvent volume, sample throughput, and evaporation time, you can get a customized estimate of how much time you could be saving every day.<h3>Why Traditional Evaporation Methods Are Holding You Back</h3>Many labs still rely on slow, manual, or outdated evaporation techniques that waste technician hours and introduce inconsistencies in sample preparation. Here are some of the most common methods—and their drawbacks:<h4 style="font-size:20px;">1. Evaporating Samples One by One by Hand</h4>Manually monitoring each sample while waiting for solvent evaporation is tedious and inefficient. This method requires constant supervision, limiting the amount of work a technician can complete in a day. If your lab is handling multiple samples daily, the lost time quickly adds up.<h4 style="font-size:20px;">2. Air Drying in a Fume Hood</h4>While this is a simple and low-cost method, it is also one of the least efficient. Air drying can take hours or even days, depending on the solvent, solvent volume, and environmental conditions. Since it relies on passive airflow without the addition of a heat source, evaporation times can be inconsistent, and there is always a risk of contamination or sample loss due to open exposure.<h4 style="font-size:20px;">3. DIY Evaporation Setups</h4>Some labs attempt to create their own evaporation solutions using hot plates, Schlenk lines, fans, or other makeshift nitrogen setups. While these may work temporarily, they often lead to uneven evaporation, loss of volatile compounds, inconsistent results across samples, and gas leaks that waste nitrogen or compressed air.<h4 style="font-size:20px;">4. Using an Evaporator That Isn’t Optimized for Your Needs</h4>Even if your lab is using a sample evaporator, it may not be designed for your solvent type, batch size, or throughput requirements. Some evaporators work best for certain solvents but struggle with others, while others are limited by the number of samples they can process at one time. If your current evaporator isn’t properly suited for your workflow, you could still be wasting hours on unnecessary evaporation time.<h3>The Benefits of Nitrogen Evaporators</h3>Switching to a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=3&amp;manufacturerItems=540">nitrogen evaporator</a> can drastically improve lab efficiency by reducing solvent evaporation times and increasing sample throughput. Here’s how:<ul><li>Significantly Faster Evaporation – A steady stream of nitrogen paired with a gentle heat source speeds up solvent removal compared to air drying or manual evaporation, while keeping your samples safe.</li><li>Higher Sample Throughput – Process multiple samples at once, rather than evaporating them one at a time.</li><li>More Consistent Results – Avoid inconsistencies caused by passive or DIY evaporation methods. Nitrogen evaporators provide controlled, reproducible conditions for each sample.</li><li>Reduced Technician Workload – Free up lab personnel for more important tasks instead of spending hours monitoring evaporation.</li><li>Better Solvent Control – Minimize the risk of over-drying or losing volatile compounds, which can happen with passive drying or DIY methods.</li></ul><h3>Maximize Your Lab’s Efficiency Today</h3>Your lab’s time is valuable—why spend it on slow, inefficient evaporation methods? Instead of wasting technician hours on manual monitoring or unreliable setups, invest in a nitrogen evaporator that accelerates evaporation and improves consistency.To make sure the switch to a nitrogen evaporator makes sense for your lab, be sure to use our Time-Savings Calculator. Simply enter your current evaporation details and find out how that compares to the evaporation time you could expect from a nitrogen concentrator.Stop letting inefficient evaporation slow down your workflow—make the switch to nitrogen evaporation and optimize your lab’s productivity today!

How much time can I save drying my samples in a nitrogen evaporator?

In the world of natural health product (NHP) testing and certification, analytical precision and scientific rigor are paramount. At the forefront of this field stands ISURA, Canada's premier independent, non-profit analytical testing and certification organization. With their state-of-the-art laboratory facilities and commitment to the highest testing standards, ISURA has established itself as a trusted authority in the natural health products industry.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_Canada_s_Independent_Certification_Lab_Leans_on_Chromatography_Mass_Spectrometry_c9958801fe.jpg" alt="Organomation: Canada's Independent Certification Lab Leans on Chromatography - Mass Spectrometry" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_Canada_s_Independent_Certification_Lab_Leans_on_Chromatography_Mass_Spectrometry_c9958801fe.jpg 236w," sizes="100vw" width="1080" height="715"><h4>ISURA: Setting the Gold Standard in Natural Health Product Certification</h4>ISURA operates with a clear mandate: to enhance the safety of natural health products, ensure label accuracy, increase consumer confidence, and support research and development for improved test methodologies. Backed by a Scientific Advisory Committee comprised of world-renowned experts, ISURA's certification standards are among the highest globally, meeting or exceeding international standards set by organizations such as the FDA, WHO, and Health Canada [1].What truly sets ISURA apart is their comprehensive analytical approach. Their in-house test center utilizes an impressive array of state-of-the-art equipment to perform both targeted and untargeted analyses. This dual approach allows them to verify specific active ingredients with high sensitivity while also screening for unknown contaminants or adulterants that might be present in natural health products [2].At the core of their analytical capabilities lies an impressive suite of <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/chromatography-sample-preparation-guide">chromatography</a> and <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/mass-spectrometry-sample-preparation-guide">mass spectrometry instruments</a>, including:<ul><li>Headspace gas chromatography</li><li>Gas chromatography triple-quadrupole</li><li>Ultra-high performance liquid chromatography triple-quadrupole</li><li>Inductively-coupled plasma mass spectrometry</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/hplc-sample-preparation">High performance liquid chromatography</a> (HPLC) [2]</li></ul>This advanced instrumentation enables ISURA to detect over 400 known pesticide and solvent contaminants down to parts per billion (ppb), confirm product authenticity, and verify that products are free from GMOs, contaminants, and adulterants [1].<h4>The Critical Role of Sample Preparation: MICROVAP Nitrogen Evaporators</h4>In the analytical workflow of chromatography and mass spectrometry, sample preparation represents a critical step that can significantly impact results. One common bottleneck in this process is the <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/what-is-solvent-evaporation">evaporation of organic solvents prior to analysis</a>. This is where <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?manufacturerItems=540&amp;search=microvap">Organomation's MICROVAP nitrogen evaporators</a> play a vital role.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_24_Position_MICROVAP_Nitrogen_Evaporator_2_1601383cd9.jpg" alt="Organomation: 24 Position MICROVAP Nitrogen Evaporator" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_24_Position_MICROVAP_Nitrogen_Evaporator_2_1601383cd9.jpg 152w," sizes="100vw" width="3024" height="3102">The MICROVAP is a compact, efficient nitrogen blowdown evaporator designed specifically for laboratories working with small sample volumes. It provides an affordable solution for drying down samples in microplates or small volume tubes such as GC/autosampler vials and microcentrifuge tubes. The system works by directing a gentle stream of nitrogen gas onto the sample surface while simultaneously applying controlled heat, significantly accelerating the evaporation process.What makes the MICROVAP particularly valuable for analytical laboratories like ISURA is its precision and versatility. The digital temperature controls and solid aluminum heating unit provide uniform heat up to 130°C with temperature accuracy of ±2°C. This precise temperature control is essential when working with heat-sensitive compounds often found in natural health products.<h5>The MICROVAP's design features several key advantages:</h5><ol><li>Compact footprint, ideal for limited laboratory space</li><li>Digital temperature control for precise regulation</li><li>Customized aluminum heat blocks for optimal heat transfer</li><li>Even gas distribution through a specially manufactured manifold</li><li>Simple one-button operation to start or stop the evaporation process</li></ol>For laboratories processing multiple samples, the MICROVAP offers configurations that can accommodate up to 15 samples simultaneously, making it an efficient solution for batch processing.<h4>Nitrogen Evaporation in Action: A Critical Application in Research</h4>Illustrative is the recent study published in <a target="_blank" rel="noopener noreferrer" href="https://www.mdpi.com/2218-1989/14/5/265">Metabolites </a>(2024, 14(5), 265) evaluating the metabolite profiles of omega-3 fatty acid fish oil formulations. In this randomized, double-blind, crossover study, researchers employed a sophisticated analytical workflow that relied on <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392">nitrogen evaporation</a> prior to the use of analytical instrumentation. Following solid-phase extraction using a hydrophilic-lipophilic balance (HLB) sorbent, “the eluted fatty acid-rich extract was then evaporated under nitrogen and reconstituted with 50 µL of ethanol,” prior to UHPLC-MS analysis [3].In this research the nitrogen evaporation step served multiple critical purposes:<ol><li>It preserved the oxidation-sensitive omega-3 fatty acids (EPA and DHA) that could potentially degrade if exposed to oxygen during the concentration process.</li><li>It enabled effective sample concentration, which enhanced detection sensitivity for the subsequent analysis.</li><li>It facilitated the exchange of analytes between ethyl formate and ethanol, improving compatibility with the UHPLC-MS analysis method.</li></ol>The careful sample preparation, including the nitrogen evaporation step, allowed researchers to accurately measure blood concentrations of omega-3 fatty acids and their metabolites over a 24-hour period post-administration. This ultimately revealed significant differences in the bioavailability of omega-3 fatty acids between standard softgels, enteric-coated softgels, and a novel micellar formulation.<h4>Why Nitrogen Blowdown is Essential to Modern Analytical Chemistry</h4>A <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/nitrogen-blowdown-evaporator-buyers-guide">nitrogen blowdown evaporator</a> works by applying a steady stream of nitrogen gas just above the sample surface, which gently pushes vapor-saturated air away from the liquid, preventing it from returning to the remaining sample. This process offers several advantages over other evaporation methods:<ul><li>Preservation of Sample Integrity: The inert nitrogen environment prevents oxidation of sensitive compounds, a critical consideration when working with easily degradable substances like polyunsaturated fatty acids.</li><li>Controlled Evaporation Rate: The combination of gentle heat and nitrogen flow allows for precise control of the evaporation process, preventing sample loss or degradation.</li><li>Efficiency: For small volume samples in volatile or semi-volatile organic solvents, nitrogen blowdown is remarkably efficient. On average, it takes just 25 minutes to safely concentrate a 10 mL sample of methylene chloride.</li><li>Versatility: The technique is applicable across a wide range of sample types and solvents, making it ideal for laboratories that process diverse sample matrices.</li></ul><h4>Conclusion: The Perfect Partnership</h4>The partnership between advanced analytical instrumentation like ISURA's chromatography-mass spectrometry systems and precise sample preparation tools like <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?manufacturerItems=540&amp;search=microvap">Organomation's MICROVAP nitrogen evaporators </a>represents the gold standard in natural health product testing and research.ISURA's commitment to rigorous scientific analysis is enhanced by tools that ensure sample integrity throughout the analytical process. The MICROVAP's precise temperature control, efficient nitrogen delivery, and compact design make it an ideal solution for laboratories focused on accurate, reliable results.As research continues to advance our understanding of natural health products and their metabolites, the role of nitrogen evaporation in preserving sample integrity will remain critical. This gentle yet effective technique ensures that what we measure truly represents what's in the sample-not artifacts of the preparation process.For laboratories seeking to enhance their analytical capabilities, the combination of advanced chromatography-mass spectrometry and efficient nitrogen evaporation represents a powerful approach to unlocking the molecular secrets of natural health products.

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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