<p><strong>Los Angeles, California —LECO Corporation has partnered with California State University, Los Angeles, on the development of its new LECO Complex Chemical Compositional Analysis Lab. The opening of the lab on September 19th marked a significant step towards advancing research and education in complex chemical analysis not only at the university but throughout the West Coast.</strong></p>
<p>The new C3AL, as it is referred to, is located in the renovated laboratory of Rosser Hall at CSULA. Here, students, colleagues, and partners will study the composition and structure of complex chemical samples under the direction of Dr. Petr Vozka, professor in the Department of Chemistry and Biochemistry.</p>
<blockquote>
<h5><a href="https://gcms.labrulez.com/companies/219"><strong>Complex Chemical Composition Analysis Lab (C³AL)</strong></a></h5>
</blockquote>
<blockquote>
<p>We are a <strong>research group</strong> in the Department of Chemistry and Biochemistry at California State University, Los Angeles. Our research revolves around the <strong>characterization of complex chemical mixtures</strong> via state-of-the-art techniques, inlcuding <strong><a href="https://gcms.labrulez.com/library?instrumentationItems=2&amp;manufacturerItems=25">two-dimensional gas chromatography</a> and <a href="https://gcms.labrulez.com/library?instrumentationItems=3-5-13&amp;manufacturerItems=25">high-resolution mass spectrometry</a></strong>.</p>
</blockquote>
<p><em>&quot;The mission of CSULA is to mold adept students ready to lead in the industry and excel in top-tier graduate programs,&quot;</em> said <strong>Dr. Vozka</strong>. <em>&quot;Every milestone, every achievement, is a testament to our collective efforts.”</em></p>
<p><em>&quot;The opportunity to partner with Dr. Vozka and the Cal State community presented itself when we learned of Petr&#39;s commitment to educating the next generation of scientists on powerful new techniques for the identification of unknowns,&quot;</em> said <strong>Farai Rukunda</strong>, Director of Separation Science at LECO. <em>&quot;As the industry leader in instrumentation for complex sample analysis, it was a natural fit for us to work together to ensure these new and emerging leaders had exposure to and the proper training on these new revolutionary techniques.&quot;</em></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_LECO_Launches_New_Laboratory_in_Partnership_with_California_State_University_Los_Angeles_03_bcbfbd5027/LECO-LECO-Launches-New-Laboratory-in-Partnership-with-California-State-University-Los-Angeles-03.jpg" alt="LECO - LECO Launches New Laboratory in Partnership with California State University, Los Angeles 03.jpg"/></p>
<p>As part of its contribution to the new laboratory, LECO provided state-of-the-art time-of-flight mass spectrometry equipment. The Pegasus BT brings <a href="https://gcms.cz/products/36"><strong>GC</strong></a>, <a href="https://gcms.cz/products/37"><strong>GCxGC</strong></a>, and TOFMS capabilities to the laboratory and allows for deep investigations to a variety of complex samples and interesting questions. Having access to this technology provides the students at the C3AL an opportunity to collaborate with and learn from industry leaders currently using these same tools to solve real-world problems.</p>
<p>LECO, based in St. Joseph, Michigan, plans to utilize the lab for future training and product demonstrations on the West Coast as well.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_LECO_Launches_New_Laboratory_in_Partnership_with_California_State_University_Los_Angeles_05_ed3508194d/LECO-LECO-Launches-New-Laboratory-in-Partnership-with-California-State-University-Los-Angeles-05.jpg" alt="LECO - LECO Launches New Laboratory in Partnership with California State University, Los Angeles 05.jpg"/></p>
<p><em>&quot;The West Coast continues to be a hot spot for laboratories doing discovery work in the areas of unknown analyte detection, particularly in areas like Metabolomics and Environmental Forensics,&quot;</em> said <strong>Dave Russ</strong>, US Sales Manager for Separation Science. <em>&quot;The C3AL lab gives us access to a working LECO laboratory on the West Coast, so we can better support this growing community.&quot;</em></p>
<p>Following the ceremony, <strong>Christopher Warren</strong>, President of LECO Corporation, affirmed the company&#39;s commitment to supporting the lab for years to come.</p>
<p><em>&quot;This new partnership promotes advancement in research capabilities and provides students with the opportunity to make their mark on chemical analysis,&quot;</em> says <strong>Chris Warren</strong>, President of LECO Corporation. <em>&quot;As scientists ourselves, we look forward to mentoring the next generation in solving tomorrow&#39;s complex problems today&quot;.</em></p>
<p>For more information on the Cal State LA/LECO C3AL lab, please contact Dr. Petr Vozka at pvozka@calstatela.edu.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_LECO_Launches_New_Laboratory_in_Partnership_with_California_State_University_Los_Angeles_01_b628ada80f/LECO-LECO-Launches-New-Laboratory-in-Partnership-with-California-State-University-Los-Angeles-01.jpg" alt="LECO - LECO Launches New Laboratory in Partnership with California State University, Los Angeles 01.jpg"/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_LECO_Launches_New_Laboratory_in_Partnership_with_California_State_University_Los_Angeles_02_176839852e/LECO-LECO-Launches-New-Laboratory-in-Partnership-with-California-State-University-Los-Angeles-02.jpg" alt="LECO - LECO Launches New Laboratory in Partnership with California State University, Los Angeles 02.jpg"/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_LECO_Launches_New_Laboratory_in_Partnership_with_California_State_University_Los_Angeles_04_1621f2a437/LECO-LECO-Launches-New-Laboratory-in-Partnership-with-California-State-University-Los-Angeles-04.jpg" alt="LECO - LECO Launches New Laboratory in Partnership with California State University, Los Angeles 04.jpg"/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_LECO_Launches_New_Laboratory_in_Partnership_with_California_State_University_Los_Angeles_06_671613a80c/LECO-LECO-Launches-New-Laboratory-in-Partnership-with-California-State-University-Los-Angeles-06.jpg" alt="LECO - LECO Launches New Laboratory in Partnership with California State University, Los Angeles 06.jpg"/></p>


LECO Launches New Laboratory in Partnership with California State University, Los Angeles

<p>Los Angeles, CA – The College of Natural and Social Sciences at California State University, Los Angeles, is pleased to announce a significant donation from NXT Power, a leader in manufacturing advanced power quality solutions. This contribution, consisting of two state-of-the-art Uninterruptible Power Supply (UPS) units, will significantly enhance the technological capabilities of the university&#39;s Department of Chemistry &amp; Biochemistry.</p>
<p>The donated UPS units, part of NXT Power&#39;s Integrity Series, will be instrumental in safeguarding the laboratory equipment at Cal State LA&#39;s Department of Chemistry &amp; Biochemistry. These systems prevent hardware damage and disruptions, ensuring maximum uptime and safeguarding vital research activities.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Complex_Chemical_Composition_Analysis_Lab_C_AL_Cal_State_LA_Receives_Vital_Technological_Support_from_NXT_Power_4a0e5a36d6.jpg" alt="Complex Chemical Composition Analysis Lab (C³AL): Cal State LA Receives Vital Technological Support from NXT Power"/></p>
<p>Moreover, the NXT Power Integrity Max UPS system is specifically engineered to protect against degradation and disruptions in laboratory settings, which is pivotal for the university&#39;s research involving sophisticated instruments like the LECO Pegasus BT 4D GC/MS system. This support from NXT Power enhances our research capabilities and significantly contributes to our students&#39; educational and professional development.</p>
<p>This partnership with NXT Power supports our mission to prepare future scientists and innovators by providing enhanced laboratory resources. This offers our students hands-on experience with cutting-edge technology, furthering their readiness for future scientific endeavors and contributing significantly to their academic and professional growth.</p>
<p>We appreciate NXT Power&#39;s support in educating and preparing the next generation of scientists and engineers.</p>
<p>Learn more about <a href="https://www.nxtpower.com/"><strong>NXT Power</strong></a>.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Cal_State_LA_LECO_QUADJET_G_Cx_GC_coupled_to_Pegasus_BT_4_D_TOM_MS_in_the_Complex_Chemical_Composition_Analysis_Lab_C_AL_077a14ae34/Cal-State-LA-LECO-QUADJET-GCxGC-coupled-to-Pegasus-BT-4D-TOM-MS-in-the-Complex-Chemical-Composition-Analysis-Lab-(CAL).jpg" alt="Cal State LA: LECO QUADJET GCxGC coupled to Pegasus BT 4D TOM MS in the Complex Chemical Composition Analysis Lab (C³AL)"/></p>


Cal State LA Receives Vital Technological Support from NXT Power

<h3><strong>About us</strong></h3>
<p>Our laboratory is equipped with high-end mass spectrometry instruments, which offers services in field of <strong>PROTEOMICS</strong> and <strong>METABOLOMICS</strong>. All our services are available for everybody from the academic and non-academic areas.</p>
<h5><a href="https://www.biocev.eu/en/services/omics-mass-spectrometry-core-facility.6#core-facility-services"><strong>Our Services:</strong></a></h5>
<ul>
<li><strong>Preparation of samples</strong> for analysis (cells, body fluids, tissues, plants etc.)</li>
<li><strong>Targeted</strong> or <strong>untargeted</strong> <strong>proteomics</strong> and <strong>metabolomics</strong> analysis</li>
<li><strong>Data analysis</strong> and basic statistical evaluation</li>
<li><strong>Consultation</strong> of experimental design and the results</li>
</ul>
<h5><strong>Proteomics:</strong></h5>
<p>We are modern well equipped laboratory with the technical background able to perform most of the currently used <a href="https://www.biocev.eu/en/services/omics-mass-spectrometry-core-facility.6/untargeted-proteomics.24?t=s"><strong>untargeted</strong></a> and <a href="https://www.biocev.eu/en/services/omics-mass-spectrometry-core-facility.6/targeted-proteomics.25?t=s"><strong>targeted</strong></a> proteomic measurements. We provide full proteomics service, including protein isolation from the supplied sample to evaluation and consultation of the measured data. Since 2015, we handle approximately 300 orders per year (roughly 3000 samples). Results based on measurements from our laboratory were used in dozens of publications. To consult your plan, please contact Karel Harant (karel.harant@natur.cuni.cz) or Pavla Talacko (pavel.talacko@natur.cuni.cz).</p>
<h5><strong>Metabolomics:</strong></h5>
<p>As a service, we provide <a href="https://www.biocev.eu/en/services/omics-mass-spectrometry-core-facility.6/targeted-metabolomics.26?t=s"><strong>targeted</strong></a> and <a href="https://www.biocev.eu/en/services/omics-mass-spectrometry-core-facility.6/untargeted-metabolomics.30?t=s"><strong>untargeted</strong></a> analysis of small molecules. Thanks to the combination of equipment for <strong>LC-MS</strong> and <strong>GCxGC-MS</strong>, it is possible to measure a wide range of small molecules. We use several types of <strong>C18</strong> and <strong>HILIC</strong> stationary phase columns on LC. For GC, we have various columns for different types of analytes. Individual measuremnts must always be consulted in advance, an individual approach and method must be chosen for each group of molecules. Please contact Olga Součková (souckoo@natur.cuni.cz) for LC-MS or Petr Žáček (zacek@natur.cuni.cz) for GCxGC-MS.</p>
<blockquote>
<p><strong>All our services are available for everybody from the academic and non-academic areas.</strong></p>
</blockquote>
<blockquote>
<p><strong>Contact us before you start your first experiment: +420 325 873 925!</strong></p>
</blockquote>
<blockquote>
<p><strong>23.7.2024 Waiting time from “sample to result” is approximately 6-8 weeks.</strong></p>
</blockquote>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_cover_image_7cb6de4462.jpg" alt="BIOCEV: BIOCEV OMICS Mass Spectrometry Core Facility"/></p>
<h3><strong>Services</strong></h3>
<ul>
<li>Preparation of samples for analysis</li>
<li>Untargeted and targeted proteomics</li>
<li>Untargeted and targeted metabolomics</li>
<li>Data analysis and basic statistical processing</li>
<li>Consultation of experiment design and measured data</li>
</ul>
<h4><strong>Untargeted proteomics</strong></h4>
<h5><strong>Up to 8000 identified proteins in one injection.</strong></h5>
<p>A basic type of proteomic experiment. Complete lysate is digested with trypsin. The resulting peptides are desalted and separated on a reverse phase column. Due to the low amount of proteins and the high complexity of the sample, liquid chromatography is currently most often used in nanoflow - hundreds of nanoliters per minute. Liquid chromatography is directly connected to the electrospray of the Orbitrap Fusion or Orbitrap Ascend mass spectrometer. The mass spectrometer measures alternately in two modes: MS¹, where peptide masses are measured in the Orbitrap with high resolution and accuracy, and MS², in which peptides selected from the previous MS¹ scan are fragmented. These are measured either again in the Orbitrap or in the ion trap. The ion trap provides lower accuracy and resolution than the Orbitrap, but is faster and more sensitive.</p>
<blockquote>
<p><strong>We offer untargeted proteomics measurement and analysis of post-translational modifications in different types of samples (cells, tissues, body fluids, plant samples, etc.).</strong></p>
</blockquote>
<blockquote>
<p><strong>Our newest service is &quot;Thermal proteome profiling (TPP)&quot; that allows you direct detection of drug-protein interactions in living cells.</strong></p>
</blockquote>
<h5><strong>Examples of analyses:</strong></h5>
<ul>
<li>LFQ (label free quantification)</li>
<li>TMT (tandem mass tags)</li>
<li>TPP (Thermal proteome profiling)</li>
<li>phosphoproteome profiling</li>
<li>pull-down experiments</li>
</ul>
<h5><strong>Tips for sample handling:</strong></h5>
<ul>
<li>do not use trypsin for cell harvesting</li>
<li>inform us about presence of detergent</li>
<li>always keep in mind same protein loading for pull-down experiments (eg. Co-immunoprecipitation)</li>
<li>do not use phosphatase inhibitors for phosphoproteomic experiments</li>
</ul>
<h4><strong>Targeted proteomics</strong></h4>
<h5><strong>Accurate quantification of selected proteins.</strong></h5>
<p>Method aims to validate the results from an untargeted approach. It is performed on a triple quadrupole in SRM mode or using the MRM method on an Orbitrap. It is an an alternative approach to common techniques such as western blot. The advantage of this approach is the possibility to analyze several proteins (dozens) at once during one injection. This eliminates the problem of finding suitable antibodies.</p>
<blockquote>
<p><strong>The targeted proteomics service is always project specific and we offer it after prior meeting with the customer.</strong></p>
</blockquote>
<p>Parallel analysis of peptides labeled with heavy amino acids is essential. These serve as an internal standards.</p>
<p>The amount of proteins that can be targeted in one injection using a triple quadrupole, is strongly dependent on the concentration of the target proteins in the sample. The lower the expression of the target proteins, the less it is possible to analyze them in one injection due to the need for higher loading times. Information of fragmentation properties of targeted peptides is also important. This is usually obtained from an untargeted experiment, which should precede the targeted proteomic analysis. If the protein of interest was not detected during an untargeted experiment, then its targeted analysis is very difficult. However, in some cases fragmentation information can be obtained from publicly available databases.</p>
<h5><strong>Tips for sample handling:</strong></h5>
<ul>
<li>do not use trypsin for cell harvesting</li>
<li>inform us about presence of detergent</li>
<li>always keep in mind same protein loading for pull-down experiments (eg. Co-immunoprecipitation)</li>
<li>do not use phosphatase inhibitors for phosphoproteomic experiments</li>
</ul>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_Targeted_proteomics_1_f0605d8efc.jpg" alt="BIOCEV: Introducing BIOCEV OMICS Mass Spectrometry Core Facility - Targeted proteomics."/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_Targeted_proteomics_2_f1af260d27.jpg" alt="BIOCEV: Introducing BIOCEV OMICS Mass Spectrometry Core Facility - Targeted proteomics."/></p>
<h4><strong>Untargeted metabolomics</strong></h4>
<p>The goal of untargeted metabolomics is to cover the widest possible spectrum of metabolites present in the sample, their identification, and quantification. The development of this approach was made possible by the recent advances in instrumentation and computing. Our laboratory equipment enables non-targeted analyses by liquid and gas chromatography.</p>
<blockquote>
<p><strong>We offer untargeted analyses of metabolites in various biological matrices and basic statistical evaluation of the data (Figure 2, 3, 4).</strong></p>
</blockquote>
<blockquote>
<p><strong>Our newest service is stable isotope tracing (Figure 1).</strong></p>
</blockquote>
<p>HPLC-MS/MS (Figure 2): Analyzes are performed on Thermo Scientific equipment on an Ultimate 3000 liquid chromatograph coupled to an Orbitrap Fusion mass detector. The measured data are evaluated by the Compound Discoverer software.</p>
<p>GCxGC-MS (Figure 3): Analyzes are performed on a two-dimensional comprehensive chromatograph connected to a Pegasus 4D mass detector. We evaluate the data in ChromaTOF v4.5 software.</p>
<p>The liquid chromatography method covers non-volatile substances, generally polar, soluble in water, and polar organic solvents (methanol, acetonitrile...). The gas chromatography method is more suitable for analyzing stable volatile non-polar substances up to a weight of approx. 1000 Da. The range of measured substances can be increased for both methods eg., by chemical modifications (derivatization) of the analyzed molecules, which adjust their polarity and volatility (for GC) and/or stability (for LC). We choose a suitable technique or a combination of several techniques based on prior consultation with the customer.</p>
<p>The untargeted analysis results in a list of substances found in the samples, a proposal of probable structures, and an indication of the quantity of individual compounds. We also provide a basic statistical evaluation focusing on looking for differences between the tested sample groups (Figure 4).</p>
<h5><strong>Tips for sample handling:</strong></h5>
<ul>
<li>do not use phosphate buffers in the sample</li>
<li>inform us about sample type, growth medium, chemicals used, etc.</li>
</ul>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_Untargeted_metabolomics_Fig_1_11750e6992.jpg" alt="BIOCEV: Introducing BIOCEV OMICS Mass Spectrometry Core Facility - Untargeted metabolomics Fig. 1."/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_Untargeted_metabolomics_Fig_2_5ca1521705.jpg" alt="BIOCEV: Introducing BIOCEV OMICS Mass Spectrometry Core Facility - Untargeted metabolomics Fig. 2."/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_Untargeted_metabolomics_Fig_3_f4f1050fc5.jpg" alt="BIOCEV: Introducing BIOCEV OMICS Mass Spectrometry Core Facility - Untargeted metabolomics Fig. 3."/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_Untargeted_metabolomics_Fig_4_b3e198dbc9.jpg" alt="BIOCEV: Introducing BIOCEV OMICS Mass Spectrometry Core Facility - Untargeted metabolomics Fig. 4."/></p>
<h4><strong>Targeted metabolomics</strong></h4>
<p>Targeted metabolomics includes analyses of selected metabolites, which are then detected selectively and with greater sensitivity than applying an untargeted approach. It is also possible to quantify substances both relatively and absolutely. In the case of absolute quantification, it is necessary to supply a suitable labeled analog of the determined substance.</p>
<blockquote>
<p><strong>We offer analysis of primary cellular metabolites - see List of substances.</strong></p>
</blockquote>
<blockquote>
<p><strong>We analyze metabolites in tissues, cell pellets, incubation media, and body fluids (plasma, urine...).</strong></p>
</blockquote>
<blockquote>
<p><strong>We also offer the possibility of developing a method for the analysis of substances that are not in the attached list or for other matrices.</strong></p>
</blockquote>
<p>The attached list contains substances with the analysis of which we have experience. We adapt each method to the type of experiment and matrix. We can develop a method for any substance or group of substances capable of being detected by liquid and gas chromatography techniques (both connected to a mass detector or a UV detector in liquid chromatography). In the case of the development of a new method, it is necessary to supply the standards of these substances.</p>
<h5><strong>Tips for sample handling:</strong></h5>
<ul>
<li>do not use phosphate buffers in the sample</li>
<li>inform us about sample type, growth medium, chemicals used, etc.</li>
</ul>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_Targeted_metabolomics_List_of_substances_a6a4198b34.jpg" alt="BIOCEV: Introducing BIOCEV OMICS Mass Spectrometry Core Facility - Targeted metabolomics: List of substances."/></p>
<h3><a href="https://www.biocev.eu/en/services/omics-mass-spectrometry-core-facility.6#core-facility-equipment"><strong>Equipment</strong></a></h3>
<h4><strong>Mass spectrometers</strong></h4>
<h5><strong>Orbitrap Ascend</strong></h5>
<ul>
<li><a href="https://lcms.labrulez.com/library?instrumentationItems=31-32-33-30&amp;mainauthorItems=3&amp;search=Ascend"><strong>Application in the LabRulezLCMS library</strong></a></li>
</ul>
<p>Thermo Scientific Orbitrap Ascend Tribrid mass spectrometer, offering new capabilities for multiplexed proteomics and native protein characterization. The mass spectrometer enables improved sample throughput, versatility and ease-of-use — producing high quality data with simplicity. More samples can be analyzed at lower concentrations, enabling faster, more sensitive analysis, and macromolecule experiments, that were not possible before, can now be achieved. The new Auto-Ready ion source for calibration maximizes convenience, allowing the user to spend more time on the results, and less time on instrument set-up.</p>
<h5><strong>Orbitrap Fusion</strong></h5>
<ul>
<li><a href="https://lcms.labrulez.com/library?instrumentationItems=31-32-33-30&amp;mainauthorItems=3&amp;search=Fusion"><strong>Application in the LabRulezLCMS library</strong></a></li>
</ul>
<p>Mass spectrometer combining Quadrupole, Ion trap and Orbitrap. The quadrupole is used as a mass filter for the selection of precursors, after which the instrument branches and the ions can travel either to the Orbitrap - a very accurate and high-resolution mass analyzer that uses the Fourier transform to determine their mass, or to the collision cell, where they can be fragmented. From there, the path leads either back to the Orbitrap or further to the linear ion trap. This serves as the second mass analyzer in the device. It is less accurate and low-resolution, but provides greater sensitivity and the possibility of ion fragmentation. Fragmentation products can be isolated in the trap and fragmented again. This enables analysis in MS³ and even higher levels of fragmentation.</p>
<h5><strong>TSQ Quantiva Triple Quadrupole Mass Spectrometer</strong></h5>
<ul>
<li><a href="https://lcms.labrulez.com/library?instrumentationItems=31-32-35&amp;mainauthorItems=3&amp;search=Quantiva"><strong>Application in the LabRulezLCMS library</strong></a></li>
</ul>
<h5><strong>Leco - Pegasus® 4D GCxGC-TOFMS</strong></h5>
<ul>
<li><a href="https://gcms.labrulez.com/library?instrumentationItems=3-13-2&amp;mainauthorItems=24&amp;search=4D"><strong>Application in the LabRulezGCMS library</strong></a></li>
</ul>
<h4><strong>Liquid chromatography</strong></h4>
<ul>
<li>nano LC Thermo Dionex Ultimate 3000</li>
<li>LC Thermo Dionex Ultimate 3000</li>
</ul>
<h4><strong>Sample preparation</strong></h4>
<ul>
<li>KingFisher Flex</li>
<li>vacuum concentrator</li>
<li>Low flow fraction collector - Spider</li>
<li>Bioruptor pico - sonication bath</li>
</ul>
<h4><strong>Software</strong></h4>
<ul>
<li>Spectronaut 19</li>
<li>FreeStyle</li>
<li>ChromaTOF 4.5</li>
<li>Proteome Discoverer 2.2</li>
<li>Scaffold Q+S 4.6.1</li>
<li>Compound Discoverer 3.3</li>
<li>TraceFinder</li>
</ul>
<h5><strong>Software - Freeware</strong></h5>
<ul>
<li>LipidHunter</li>
<li>MaxQuant</li>
<li>Perseus</li>
<li>Skyline</li>
</ul>
<h3><a href="https://www.biocev.eu/en/services/omics-mass-spectrometry-core-facility.6#core-facility-team"><strong>Team</strong></a></h3>
<h5><strong>Mgr. Karel Harant</strong></h5>
<ul>
<li>Head of Proteomic Core Facilty</li>
</ul>
<h5><strong>Mgr. Pavel Talacko</strong></h5>
<ul>
<li>Non-targeted proteomics, targeted proteomics</li>
</ul>
<h5><strong>RNDr. Petr Žáček, Ph.D.</strong></h5>
<ul>
<li>GC / MS specialist, small molecule analysis</li>
</ul>
<h5><strong>Mgr. Veronika Ševců</strong></h5>
<ul>
<li>researcher, preparation of proteomic samples</li>
</ul>
<h5><strong>RNDr. Petr Žáček, Ph.D.</strong></h5>
<h5><strong>Mgr. Veronika Ševců</strong></h5>
<ul>
<li>researcher, preparation of proteomic samples</li>
</ul>
<h5><strong>Ing. Olga Součková, Ph.D.</strong></h5>
<ul>
<li>LC/MS specialist, small molecule analysis</li>
</ul>


Introducing BIOCEV OMICS Mass Spectrometry Core Facility

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We are a research group in the Department of Chemistry and Biochemistry at California State University, Los Angeles. Our research revolves around the characterization of complex chemical mixtures via state-of-the-art techniques, including two-dimensional gas chromatography and high-resolution mass spectrometry.

Complex Chemical Composition Analysis Lab (C³AL)

In 1936, the Laboratory Equipment Company introduced the first rapid carbon determinator for the American iron and steel industry.  Today, almost 80 years later, LECO is recognized globally as a leader in the development of high-quality analytical instrumentation, mass spectrometers, comprehensive two-dimensional chromatography, metallography & optical equipment as well as consumables.

LECO

BIOCEV is a scientific centre of excellence in biotechnology and biomedicine, which aims to detailed study of cellular mechanisms at the molecular level, research and development of novel therapeutic strategies, early diagnostics, biologically active agents including chemo-therapeutics, protein engineering and other technologies. Endowed with superb instruments and equipment, BIOCEV brings together enthusiastic teams of well-trained scientists from six institutes of the Czech Academy of Sciences and two faculties of the Charles University.

BIOCEV

Pittcon 2026

36th MassSpec Forum Vienna 2026

US HUPO 2026

The science of next-gen ingredients: fermentation, formulation and function

The Data Driven Plant; How AI Transforms Chemical Manufacturing

Process Raman: A Reliable and Versatile Tool For Downstream Process Monitoring and Control For mAB Production