<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 24th February 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies, Knauer&nbsp; </strong>and <strong>Shimadzu</strong>!</p><h4><strong>1. Agilent Technologies: Analysis of 65 Volatile Organic Compounds in Ambient Air by Canister Sampling Using an Agilent </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=8890%2F5977"><strong>8890/5977</strong></a><strong> GC/MSD</strong></h4><h5><strong>A method using both scan and SIM mode that fully meets the requirements in the HJ 759-2023 standard</strong></h5><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_voc_air_gc_msd_5994_7723en_agilent_4b88e40417.pdf"><strong>Full PDF for download</strong></a></li></ul><p>This application note introduces the use of a canister for gas sampling. Samples were introduced into an Agilent 8890 gas chromatograph (GC) with an Agilent 5977 single quadrupole mass selective detector (MSD) and the Markes Multi-Gas thermal desorption (TD), to analyze volatile organic compounds (VOCs) in the atmosphere or in semiconductor cleanrooms. The results of linearity, reproducibility, and detection limit fully met the requirements of the China method HJ759-2023. This method is widely used as a reference both in environmental laboratories and semiconductor cleanrooms. The linear correlation coefficient for all 65 compounds was greater than 0.991, with 86% of compounds having a value greater than 0.999. The results of reproducibility in scan mode varied between 0.3 to 6.8%, while results in SIM mode varied between 1.1 to 6.7%. The sampling volume was 300 mL, which resulted in detection limits of 0.013 to 0.113 nmol/mol for scan mode and 0.002 to 0.013 nmol/mol for SIM mode.&nbsp;</p><h4><strong>Experimental</strong></h4><p>This study was performed on an 8890 GC coupled to a 5977 single quadrupole GC/MSD with an electron ionization (EI) source. A Markes Multi-Gas thermal desorption sample introduction and preconcentration system was used and included three modules:</p><ul><li>CIA Advantage-xr (CIA): canister autosampler</li><li>Kori-xr: water removal module</li><li>Unity-xr: thermal desorption instrument</li></ul><p>First, three internal standards (ISTDs) were introduced into the Unity trap by CIA. Then, the sample was passed through a heated transfer line through the CIA Advantage<br>into the Kori for water removal. Finally, the sample flowed into the focusing cold trap of the Unity for preconcentration. Eventually, the Unity trap was desorbed at high temperature, and the 65 VOCs and three ISTDs all entered the GC/MSD for analysis. Figure 1 shows the flow path of the combined system.&nbsp;</p><h4><strong>Conclusion</strong></h4><p>An Agilent 8890/5977 GC/MSD system, equipped with a Multi-Gas CIA Advantage-xr TD provides a robust analytical procedure for the analysis of 65 VOCs in ambient air. This system offers a highly efficient and highly sensitive solution for the simultaneous analysis of multiple VOCs in both atmospheric quality monitoring laboratories and semiconductor cleanrooms. Based on different application requirements, users can choose to collect data in scan or SIM mode, demonstrating the flexibility of Agilent instruments. Excellent analytical performance has been achieved based on this system both in scan and SIM mode, which fully meets the requirements detailed in method HJ 759-2023.</p><h4><strong>2. Knauer: GPC vs. SPE and subsequent determination of polycyclic aromatic hydrocarbons using GC/MS</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/VEV_0081_Comparison_of_GPC_and_SPE_purification_methods_of_sludge_samples_FINAL_web_376100390f.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants generated primarily during the incomplete combustion of organic materials. The removal of PAHs from the atmosphere by dry and wet deposition processes are strongly influenced by their gas/particle partitioning. Atmospheric deposition is a major source for PAHs in soil [1] which can be determined by various extraction and purification processes, subsequently detected by a GC/MS using the reference method UNI EN 15527. Our main purpose is to demonstrate that the purification of environmental matrix with high organic component using the gel permeation chromatography purification (AZURA GPC Cleanup, FS conditioned resins CHEX/DCM), compared to a SPE purification, allows are well-defined separation time of the analytes and it can provide narrow bands without their physical chemical interaction with the column, resulting in less chance of loss of analytes [2]. This differs from other separation techniques which depend upon chemical or physical interactions to separate analytes [3].</p><h4><strong>Conclusion</strong></h4><p>The GPC cleanup procedure of mud sludge samples prior analysis of PAHs with GC/MS technique is a good alternative to SPE purification steps. Advantages like better S/N ratios and third mass identification are obvious. The automatization of the GPC Cleanup using AZURA GPC Cleanup system yields high efficiency of the application.</p><h4><strong>3. Shimadzu: Material Analysis of Microplastics in River Water - FTIR and Pyrolysis-GC-MS Analysis</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00806_en_c2c7bba8be.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>Automated pretreatment of microplastics (MPs) reduces workload and enables highly reproducible pretreatment.</li><li>Material analysis of MPs processed by the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=MAP-100"><strong>MAP-100</strong></a> device can be easily performed by <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=FTIR-ATR"><strong>FTIR+ATR.</strong></a></li><li>Highly reproducible GC-MS analysis of MPs is possible by homogeneously pulverizing samples with Cryogenic Mill (IQ MILL-2070).</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=EGA%2FPY-3030D"><strong>Pyrolysis</strong></a>-<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=GCMS-QP2020+NX"><strong>GC-MS</strong></a> can measure the weight of multiple types of plastics even when they are mixed.</li></ul><p>Microplastics (MPs) are microscopic plastic particles measuring a few µm to 5 mm in size. They are feared to have an impact on ocean pollution and ecosystems. Against this backdrop, surveys and studies on MPs in surface waters such as oceans, rivers, lakes and marshes are being conducted worldwide. Fourier Transform Infrared Spectrophotometer (FTIR) is often used for material analysis of MPs. ASTM recently published the D8401-24 standard test method for the qualitative and quantitative determination of MPs in water that uses a pyrolysis gas chromatograph mass spectrometer (Py-GC-MS). In this application news, a sample taken from a river was pretreated and analyzed for MPs using FTIR and Py-GC-MS.</p><h4><strong>Conclusion</strong></h4><p>Samples collected from river water were automatically pretreated using MAP-100, and the MPs materials were then analyzed by FTIR and Py-GC-MS. PP, PE and EVA were detected in both instruments, indicating that PP and PE are the main components (Fig. 8). Using an FTIR, individual qualitative results can be obtained easily, and the number ratios and densities can be calculated. Py-GC-MS also provides a more accurate massto material ratio (%). The system supports screening methods that take advantage of the features of each instrument, from preparation to analysis of MPs.</p>

News from LabRulezGCMS Library - Week 9, 2025

<p><strong>In the week from February 24, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong data-start="64" data-end="165">1. Agilent Technologies: Detecting Microplastics in Cannabis: An Analysis Using LDIR Spectroscopy</strong></h5><ul data-start="167" data-end="214"><li data-start="167" data-end="201">Tu, 25.2.2025</li><li data-start="202" data-end="214"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/2772">Registration</a></li></ul><p data-start="216" data-end="280">Detecting Microplastics in Cannabis: An Analysis Using LDIR Spectroscopy.</p><h5><strong data-start="282" data-end="393">2. Separation Science/Biotage: Automated Sample Preparation for Multi-Residue Pesticide Analysis by LC-MS and GC-MS</strong></h5><ul data-start="395" data-end="443"><li data-start="395" data-end="430">We, 26.2.2025</li><li data-start="431" data-end="443"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4724">Registration</a></li></ul><p data-start="445" data-end="600">Learn how Biotage's automated preparation workflow can analyze the entire panel and produce results equivalent to manual preparation.</p><h5><strong data-start="602" data-end="718">3. LECO: Detailed Hydrocarbon Type Analysis of Aviation Fuels: Navigating the Challenges of Evolving Feed Stocks</strong></h5><ul data-start="720" data-end="768"><li data-start="720" data-end="755">We, 26.2.2025</li><li data-start="756" data-end="768"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4687">Registration</a></li></ul><p data-start="770" data-end="979">This webinar will review both historical and contemporary analytical methods used for HTA, with a focus on the evolving challenges associated with achieving accurate identification and quantification with GCxGC</p><h5><strong data-start="602" data-end="718">4. Wiley: Advances in Spectral Identification: SmartSpectra, Classifications, &amp; More!</strong></h5><ul data-start="720" data-end="768"><li data-start="720" data-end="755">We, 26.2.2025</li><li data-start="756" data-end="768"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4789">Registration</a></li></ul><p data-start="770" data-end="979">This webinar covers the latest advances in spectral analysis, including Wiley’s KnowItAll models, SmartSpectra, and functional group analysis tools.</p>

Webinars LabRulezGCMS Week 9/2025

Ionic liquid coating for stir bar sorptive extraction and its application for extraction and nontargeted screening analysis via TD-GC–Orbitrap-HRMS of pollutants in river water

<p><strong>In the week from March 3, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong data-start="64" data-end="165">1. Agilent Technologies: </strong><strong>Application of GC/MS for the Analysis of Poly-Aromatic Hydrocarbons (PAHs) and Pesticides in Drinking Water According to the Directive EU 2020/2184</strong></h5><div><div><ul><li><div>We, 5.3.2025 14:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4712">Registration</a></div></li></ul></div><p>The main analytical techniques for the analysis of PAHs and pesticides in GC/MS in drinking water, with particular attention to the Solid Phase Micro-Extraction (SPME) technique.</p></div>

Webinars LabRulezGCMS Week 10/2025

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 3rd March 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you poster by <strong>Agilent Technologies </strong>and application notes by<strong> Knauer, Shimadzu </strong>and <strong>Thermo Fisher Scientific</strong>!</p><h4><strong>1. Agilent Technologies: GC/MS Approach for Analysis of</strong><br><strong>Extractables and Leachables (E&amp;L) in Complex Matrices Using Spectral Deconvolution and Retention Indices</strong></h4><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_7250_5977c_extractable_leachable_asms_2024_mp208_en_agilent_71b19d3b16.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Modern drug delivery systems are meant to protect a drug from environmental contamination, but they may also be a source of contamination. It is necessary to identify those compounds that can extract, leach, or migrate from the package or device. Extractables and leachables analysis presents a challenge for GC/MS because of the complexity of the various sample matrices and a diverse range of compounds to be identified. This study demonstrates how unit resolution GC/MS workflow is employed for identifying GC-amenable E&amp;L compounds by leveraging spectral deconvolution in combination with retention index-based time filtering. An addition of the accurate mass high-resolution GC/Q-TOF into the workflow provided extra confidence in compound identification, sensitivity and capability of structural elucidation.&nbsp;</p><p>Operating in the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=OpenLab+ECM"><strong>OpenLab Electronic Content Management </strong></a>(ECM) XT configuration enabled tools that help facilitate compliance with various national and EU electronic record regulations, including audit trails, and remote data storage.</p><h5><strong>Experimental</strong></h5><p>Rubber syringe gaskets were extracted using tetrahydrofuran (THF) solvent at room temperature for six months. An aliquot of the extracts was analyzed using both <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=GC%2FMSD"><strong>GC/MSD</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=GC%2Fq-TOF"><strong>GC/Q-TOF</strong></a> systems. The acquisition software operated under a unified compliance environment. The instrumental parameters are shown in Table 1. The chromatographic deconvolution and library search were performed in the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=MassHunter"><strong>MassHunter</strong></a> Unknowns Analysis 12.1. The NIST23 library was used to perform initial compound identification. Structural elucidation was performed using Molecular Structure Correlator (MSC) software 8.2.&nbsp;</p><p>Retention time locking was used to achieve the same retention times between multiple GC/MSD and GC/Q-TOF systems allowing for using both retention index and retention time matching.</p><h5><strong>Conclusions</strong></h5><ul><li>The optimized GC/MSD and GC/Q-TOF approach for analysis of extractables and leachables allowed for identifying over 150 compounds in a complex E&amp;L extract&nbsp;</li><li>High-resolution GC/MS enabled identification of over 60 additional components with increased confidence and structure elucidation of the unknowns&nbsp;</li><li>The novel ultra low bleed Agilent <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=J%26W+DB-5Q"><strong>J&amp;W DB-5Q</strong></a> GC column resulted in significant decrease in background, that could potentially yield higher number of identifications of late eluting compounds.</li></ul><h4><strong>2. Knauer: GPC cleanup method for soil samples before PAHs analysis</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/VEV_0082_GPC_Cleanup_of_soil_samples_FINAL_web_5260b86091.pdf"><strong>Full PDF for download</strong></a></li></ul><p>GPC (Gel Permeation Chromatography) is a size-exclusion clean-up procedure that readily separates high molecular weight interferents from sample extracts using organic solvents and a porous hydrophobic gel (primarily a crosslinked divinylbenzene-styrene copolymer) [1]. It is possible to distinguish between different types of Bio-Beads resin based on the type of cross-linkage. In this application Bio-Beads S-X3 with 200–400 mesh was used according to EPA method 3640 [1]. GPC clean-up can be used extensively in numerous environmental analysis especially for preparing sample extracts prior to semivolatile compounds determination, such as pesticide, and PAHs analysis by GC/MS or HPLC-UV-DAD. Sample cleanup is particularly important for analytical separations such as GC, HPLC, and electrophoresis because high-boiling materials can cause a variety of problems in analytical systems, like analyte adsorption in the injection port or in front of a GC or LC column [2]. GPC cleanup protects GC and HPLC columns, reduces analytical maintenance costs, improves accuracy, and allows lower detection limits.</p><h5><strong>Materials and Methods</strong></h5><p>Extraction of Polycyclic Aromatic Hydrocarbons was carried out using Accelerated Solvent Extraction (ASE), according to the 3545A EPA method [3]. Bio-Beads S-X are supplied dry and must be swollen prior to pack into a chromatographic column. A mixture of cyclohexane and dichloromethane (70:30, v:v) is suitable for clean-up of soil samples. As a general rule, the beads should be swollen in the same solvent chosen as mobile phase, so 10 g of Bio-Beads S-X3 were swelled with 50 mL of cyclohexane and dichloromethane mixture (70:30, v:v) overnight. After the beads were fully swollen, they were packed into a chromatographic column. Before sample cleanup, GPC column was equilibrated with the desired solvent mixture, flushing it almost three times the column volume at 1 mL/min. Cleanup method was performed with AZURA® GPC Cleanup System, which is operated with the Mobile Control Chrom® Software running on a tablet directly mounted on the system. The identification and quantification of PAHs was carried out by GC-MS/MS analysis. Calibration curves were constructed in the concentration range from 10 μg/L to 130 μg/L. To perform GC separation and MRM acquisition, optimization of the best chromatographic and detection conditions was necessary.</p><h5><strong>Conclusion</strong></h5><p>This application shows how to perform GPC cleanup with KNAUER AZURA® GPC Cleanup System for the analysis of PAHs in soil samples. This report is very detailed to ensure good performance in GPC cleanup for application in environmental area. We can conclude that AZURA GPC Cleanup System is an helpful tool for sample preparation before instrumental analysis because, unlike other techniques, is very useful for the removal of high boiling materials which would contaminate injection ports and column heads, prolonging column life, stabilizing the instrument, and reducing column reactivity. It could be considered an universal cleanup technique for a broad range of semivolatile organics and pesticides. Moreover, AZURA GPC Cleanup System allows the customer to process many extracted samples, with a reduction in time for the cleanup procedures.</p><h4><strong>3. Shimadzu: Blood alcohol content (BAC) analysis using a liquid injection approach</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/AP_Blood_alcohol_content_via_liquid_injection_SCA_180_051_294d6843f8.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>Blood alcohol analysis using liquid injection is an alternative to the headspace</li><li>analysis of blood samples for clinical purposes</li><li>It provides reliable results for whole blood and plasma samples without adverse matrix effects&nbsp;</li></ul><p>Blood alcohol content (BAC) is relevant for legal regulations regarding driving limits, but also investigated for forensic and clinical purposes with respect to poisoning. Blood alcohol analysis does not only focus on ethanol, which is the classical drinking alcohol, but also investigates other alcoholic substances like methanol and isopropanol as well as metabolites like acetone. Ethanol is present in alcoholic beverages, but also used for antiseptics, various daily life products, and pharmaceuticals. Being a central nervous system depressant, consumption can cause severe intoxication with toxic levels at above 100 mg/dL blood [1]. Methanol intoxication could originate from the consumption of counterfeit alcohol, with as few as 30 mL pure methanol consumed being potentially lethal [2]. Isopropanol is widely used as solvent or antiseptic in households and sometimes used as cheap substitute for ethanol by alcohol abusers. It is metabolized by alcohol dehydrogenase to acetone, which alike isopropanol is a central nervous depressant [3].</p><p>Blood alcohol analysis can be performed using gas chromatography (GC) with flame-ionization detection (FID). Due to the complexity of blood as matrix, headspace analysis is a widely used technique for simple sample transfer onto the GC column, which is especially valuable in forensics, where the matrix states investigated can drastically vary depending on the time the sample is taken. For clinical analysis, fresh blood is used, making the sample more uniform. In this approach, the analysis of BAC using a liquid injection technique as alternative to headspace sampling is presented.</p><h5><strong>The Package</strong></h5><p>The recommended analytical hardware and software configuration is listed below.</p><ul><li><strong>Main Unit</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=nEXIS+gc-2030+%28fid%29"><strong>Nexis GC-2030 with FID-2030</strong></a>: Gas chromatograph with flame ionization detector</li></ul></li><li><strong>Accessory</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=AOC-30i+"><strong>AOC-30i </strong></a>autosampler: Liquid autosampler with 30 vials capacity</li></ul></li><li><strong>Main Consumables</strong><ul><li>SH-BAC1 column (30 m x 0.32 mm x 1.8 µm;</li><li>P/N 221-76135-30)</li></ul></li><li><strong>Software</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=LabSolutions+LCGC"><strong>LabSolutions LCGC</strong></a></li></ul></li></ul><h4><strong>Conclusion</strong></h4><p>Liquid sample injection presents a reliable alternative to headspace injection when analyzing blood samples for clinical purposes. Ethanol and methanol can be determined from whole blood, isopropanol and acetone from plasma samples without adverse matrix effects. Both whole blood and plasma analysis can be done using the same analytical method and one data processing approach, facilitating data evaluation and routine work.</p><h4><strong>4. Thermo Fisher Scientific: Trace analysis of volatile organic compounds in wastewater according to U.S. EPA Method 624.1&nbsp;</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/an_003068_gc_gc_ms_isq_7610_epa_624_1_an003068_na_en_2297d596f3.pdf"><strong>Full PDF for download</strong></a></li></ul><p>It is crucial that analytical testing laboratories monitor wastewater for the presence of volatile organic compounds (VOCs). VOCs are human-made contaminants used and produced in the processing of paints, adhesives, petroleum products, pharmaceuticals, and refrigerants. If they are released into wastewater from industrial activities, they can have an adverse effect on the natural environment and, ultimately, the public.<sup>1</sup> U.S. EPA Method 624.1 is an approved test method under the Clean Water Act<sup>2</sup> for determination of purgeable organic pollutants in industrial discharges and other environmental samples. The accurate detection and quantitation of VOCs via this method help ensure wastewater is not contaminated. Due to technological advances in analytical instrumentation and techniques, U.S. EPA Method 624.1 allows the analyst to modify P&amp;T parameters and GC/MS conditions. This can result in reduced sample run time and increased laboratory throughput in a 12-hour period.&nbsp;</p><p>To perform U.S. EPA Method 624.1, method acceptance criteria must be achieved. These criteria include creating a working calibration curve, method detection limits (MDLs), and Initial Demonstration of Capability (IDC) of accuracy and precision for target compounds. As the sample matrix is water, it is essential that moisture is reduced, limiting the impact on the analytical column as this could damage the column and affect the results.&nbsp;</p><p>The following evaluation describes the use of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=ISQ+7610"><strong>ISQ 7610</strong></a> GC-MS system coupled with a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=TRACE+1610"><strong>TRACE 1610 GC</strong></a> equipped with the Thermo Scientific™ HeSaver-H2 Safer™ split/splitless injector and a Teledyne LABS Tekmar Lumin P&amp;T concentrator paired with the AQUATek LVA autosampler for U.S. EPA Method 624.1 for the analysis of wastewater.</p><h5><strong>Experimental</strong></h5><h5><strong>GC-MS parameters&nbsp;</strong></h5><p>A TRACE 1610 GC was coupled to the ISQ 7610 MS equipped with a Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=NeverVent"><strong>NeverVent™ </strong></a>vacuum probe interlock (VPI) and a Thermo Scientific™ ExtractaBrite™ ion source. A Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=TraceGOLD"><strong>TraceGOLD™ TG-VMS</strong></a>, 30 m × 0.25 mm, 1.4 µm film column (P/N 26080-3320) was used for compound separation. The HeSaver-H2 Safer injector was utilized which reduces the carrier gas consumption by decoupling the gas used for the chromatographic separation from the gas used to pressurize the inlet and maintain split and purge flows. The critical separations were maintained with a run time of under 13 minutes.&nbsp;</p><p>For this analysis, the ISQ 7610 MS was operated in full scan mode, ensuring the sensitivity needed for required the method detection limits. Nevertheless, the instrument could operate in Selected Ion Monitoring (SIM) mode for increased selectivity, if needed. Extended method parameters for the ISQ 7610 MS are shown in Table 2.</p><h5><strong>Conclusion</strong></h5><p>The ISQ 7610 MS system with the VPI coupled with the Teledyne LABS Tekmar Lumin P&amp;T concentrator paired with the AQUATek LVA autosampler exceeds all the requirements outlined in U.S. EPA Method 624.1 for analysis of VOCs in wastewater:</p><ul><li>MDLs calculated from n=7 repeat injections of 0.5 ppb water standards showed no interference from unwanted water entering the system and resulted in values &lt;0.15 ppb for most compounds.</li><li>Precision and accuracy for n=7 20 ppb water standards showed excellent results with %RSD &lt;20% and mean recovery of 93% for the compounds.</li><li>System robustness was tested by continuously acquiring 209 injections of water samples over two days with no user intervention at all. The average %RSD of the calculated concentration was 6.5% over this robustness study.</li><li>Utilizing the HeSaver-H2 Safer technology reduced helium consumption for the method by 4 times, reducing laboratory overheads.&nbsp;</li></ul><p>Further information on VOC analysis using the ISQ 7610 system and the Tekmar Lumin P&amp;T paired with the AQUATek LVA can be found in the Thermo Fisher Scientific AppsLab library.<sup>3</sup><br>&nbsp;</p>

News from LabRulezGCMS Library - Week 10, 2025

Liquid and gas-chromatography-mass spectrometry methods for exposome analysis

<p><strong>In the week from March 10, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong data-start="137" data-end="229">1. Thermo Fisher Scientific: Detecting Volatile PFAS in Water with High-Resolution GC-MS</strong></h5><ul data-start="231" data-end="400"><li data-start="231" data-end="333"><span>Tuesday, March 11, 2025, 11:00 CET</span></li><li data-start="334" data-end="400"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4812">Registration</a></li></ul><p data-start="402" data-end="483"><span>Join Principal Scientist John Quick from ALS Environmental Ltd for a webinar on using GC-HRMS to analyze fluorotelomer alcohols (FTOHs) and other volatile per- and polyfluoroalkyl substances (PFAS) in water samples.</span>​</p><h5><strong data-start="406" data-end="522">2. Separation Science/SepSolve Analytical: From Bottlenecks to Breakthroughs: Overcoming GC–MS Limitations in Non-Target Screening</strong></h5><ul data-start="524" data-end="691"><li data-start="524" data-end="607"><span>Tuesday, March 11, 2025, 11:00 CET</span>​</li><li data-start="608" data-end="691"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4739"><span>Registration</span></a></li></ul><p data-start="693" data-end="778"><span>This webinar will demonstrate how comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC×GC–TOF MS) transforms non-target screening, with practical examples from sustainable fuel analysis, aroma profiling, and essential oil characterization.</span>​</p><h5><strong data-start="780" data-end="863">3. Phenomenex: SPE Troubleshooting: Unlock Maximum Recovery with Expert Tips!</strong></h5><ul data-start="865" data-end="1040"><li data-start="865" data-end="952"><span>Tuesday, March 11, 2025, 11:00 CET</span></li><li data-start="953" data-end="1040"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4765"><span>Registration</span></a></li></ul><p data-start="1042" data-end="1127"><span>Learn how to successfully troubleshoot Solid Phase Extraction (SPE) problems quickly and efficiently to maximize recovery in your analyses.</span>​</p><h5><strong data-start="1129" data-end="1250">4. Thermo Fisher Scientific: Real-time Monitoring of Polymer Blend Extrusion Using an Inline Process Raman Analyzer</strong></h5><ul data-start="1252" data-end="1427"><li data-start="1252" data-end="1339"><span>Tuesday, March 11, 2025, 15:00 CET</span>​</li><li data-start="1340" data-end="1427"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4793"><span>Registration</span></a></li></ul><p data-start="1429" data-end="1514"><span>This webinar will explore findings from a recent study where a process Raman analyzer was coupled to a parallel twin-screw extruder for continuous in-line monitoring of polymer extrusion.</span></p><h5><strong data-start="1516" data-end="1631">5. SelectScience/VELP Scientifica: Maximize Efficiency in Fat and Oil Extraction for Quality Control and Compliance</strong></h5><ul data-start="1633" data-end="1808"><li data-start="1633" data-end="1720"><span>Tuesday, March 11, 2025, 16:00 CET</span>​</li><li data-start="1721" data-end="1808"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4842"><span>Registration</span></a></li></ul><p data-start="1810" data-end="1895"><span>In this educational webinar, Corey Letizio from Thermo Fisher Scientific will discuss strategies to maximize efficiency in fat and oil extraction processes, focusing on quality control and compliance.</span>​</p><h5><strong data-start="1897" data-end="2013">6. New Food Magazine/Nordson Measurement &amp; Control Solutions: Delivering Closed Loop Control in Baking and Frying Processes Through Online Measurement</strong></h5><ul data-start="2015" data-end="2190"><li data-start="2015" data-end="2102"><span>Wednesday, March 12, 2025, 15:00 CET</span>​</li><li data-start="2103" data-end="2190"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4768"><span>Registration</span></a></li></ul><p data-start="2192" data-end="2277"><span>Join this webinar to hear from Nordson as they discuss the benefits of simultaneous online measurement of moisture, fat/oil, protein, and color in the baking and frying industries.</span></p><h5><strong data-start="1897" data-end="2013">7.SelectScience/</strong><strong data-start="1129" data-end="1250">Thermo Fisher Scientific</strong><strong data-start="1897" data-end="2013">: Reducing the environmental impact of lab plastics with plant-based solutions</strong></h5><ul data-start="2015" data-end="2190"><li data-start="2015" data-end="2102"><span>Wednesday, March 12, 2025, 17:00 CET</span>​</li><li data-start="2103" data-end="2190"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4843"><span>Registration</span></a></li></ul><p data-start="2192" data-end="2277"><span>In this webinar, hear from experts, as they share insights on using traditional plastic-based resins compared with plant-based, focusing directly on the impact on the mass balance approach.</span></p><h5><strong data-start="2279" data-end="2397">8. Waters Corporation: Empower Tips: Ask Me Anything About the Importance of Keeping Laboratory Software Updated</strong></h5><ul data-start="2399" data-end="2574"><li data-start="2399" data-end="2486"><span>Thursday, March 13, 2025, 16:00 CET</span>​</li><li data-start="2487" data-end="2574"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4797"><span>Registration</span></a></li></ul><p data-start="2576" data-end="2661"><span>This webinar covers Empower and NuGenesis, key reasons to stay updated on software versions, and practical approaches to upgrading.</span></p><h5><strong data-start="2279" data-end="2397">9. PerkinElmer: Empower The Role of Analytical Chemistry in Battery Development &amp; Production</strong></h5><ul data-start="2399" data-end="2574"><li data-start="2399" data-end="2486"><span>Thursday, March 13, 2025, 18:00 CET</span>​</li><li data-start="2487" data-end="2574"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4845"><span>Registration</span></a></li></ul><p data-start="2576" data-end="2661"><span>In collaboration with PerkinElmer, this presentation will explore the critical role of analytical chemistry and thermal analysis in ensuring battery efficiency, safety, and performance.</span></p><h5><strong data-start="2663" data-end="2705">10. Agilent Technologies: FTIR Theory</strong></h5><ul data-start="2707" data-end="2882"><li data-start="2707" data-end="2794"><span>Thursday, March 13, 2025, 20:00 CET</span>​</li><li data-start="2795" data-end="2882"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4555"><span>Registration</span></a></li></ul><p data-start="2884" data-end="2969"><span>The intricate details of Fourier-transform infrared (FTIR) spectroscopy and data collection will be explained in this session.</span>​</p>

Webinars LabRulezGCMS Week 11/2025

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 10th March 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you poster by <strong>Agilent Technologies </strong>and application notes by<strong> Shimadzu </strong>and <strong>Thermo Fisher Scientific</strong>!</p><h4><strong>1. Agilent Technologies (ASMS 2024): Automated Sample Preparation and Analysis of OCPs in Drinking Water</strong></h4><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_pal3_rtc_ocd_drinking_water_asms_2024_mp387_en_agilent_061eb8d44c.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The Analysis of Organochlorine Pesticides (OCP’s) in drinking water is generally performed by manual liquid-liquid extraction with a concentration step performed before analysis by triple quadrupole GC/MS. Traditionally, volumes as high as 500 and 1000 mL are used and at least 100 to 200 mL of water sample is required with often over 25 mL of extraction solvent needed to extract. Hence, an additional concentration step via evaporation becomes needed.</p><h5><strong>Benefits of Automation</strong></h5><p><strong>Sample preparation automation provides multiple benefits:</strong></p><ul><li>Less room for human error – can be left unattended to run 24/7 if desired. For this method, the user only needs to add salt and sample (15 mL) to the headspace vial – the rest of the process is fully automated.</li><li>Higher reproducibility as the sample prep robot will perform actions consistently for each sample.</li><li>Significantly less sample and solvents are used resulting in a more sustainable approach.</li><li>Lower costs and higher throughput.</li></ul><h5><strong>Sample Extraction Steps</strong></h5><ul><li><strong>ISTD Spiking</strong>: Using a dedicated (for ISTD) liquid tool with a 10 µL syringe, 2 µL of ISTD (from a 2 mL autosampler vial) were pipetted into 20 mL headspace (HS) vials containing sample/standards.&nbsp;</li><li><strong>Solvent Addition:</strong> 2 mL of 90:10 isooctane:ethyl acetate solvent was added to the sample vial (20 mL HS)&nbsp;</li><li><strong>Extraction</strong>: The vial was then transported to the vortex mixer and then vortexed at 2,000 rpm for 60 seconds&nbsp;</li><li><strong>Sample Injection</strong>: Using a dedicated (for sample extracts) liquid tool with a 10 µL syringe, 1 µL of analyte protectants and then 8 µL of sample extract were injected onto the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=8890%2F7010"><strong>8890/7010</strong></a><strong> Series GC/TQ</strong></li></ul><h5><strong>Conclusions</strong></h5><ul><li>Excellent sensitivity for OCP’s ( &lt; 0.01 ug/L) was achieved with only 15ml of water taken.&nbsp;</li><li>The extraction has been shown to be reproducible and robust requiring limited analyst supervision.&nbsp;</li><li>The automation is embedded within MassHunter requiring no additional software for the control and sequencing of the analysis.&nbsp;</li><li>The incorporation of mid-column backflush has resulted in consistent responses and retention times throughout the sequences and has minimized contamination of the MS source. The additional JetClean option has resulted in no manual source cleaning being required to date.&nbsp;</li><li>The automation has been configured to enable minimal analyst interaction by the incorporation of a diluter/dispenser into a large 2.5 L solvent bottle. This way non-mixed solvents can be used together with a fast wash station that means that no contamination will result from waste solvents.</li></ul><h4><strong>2. Shimadzu: Analysis of THC Metabolites in Urine by GC-MS/MS</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00860_en_38536374fa.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>MRM in GC-MS/MS uses two-stage mass filtering which allows for the detection of THC and its metabolites without interference from impurities in urine.</li><li>Using MRM creates a method sensitive enough to detect THC and its metabolites in urine at 1 ng/mL that can be used to quantify trace levels of cannabis metabolites in urine.</li></ul><p>Cannabis is a long-abused drug with pharmacological effects that include hallucinations, pain relief, and sedation. While the main psychoactive component of cannabis, delta-9- tetrahydrocannabinol (Δ9-THC), issubject to restrictions in many countries worldwide, another active component called cannabidiol (CBD) is not regulated in many countries. Cannabidiol has no major side effects and is starting to be used as a seizure medication, in cosmetics, and in foods. Restrictions on cannabis are undergoing continuous reforms with some countries tightening restrictions and others relaxing them. Japan has recently revised its laws to tighten regulations on cannabis use and a portion of these laws went into effect in December 2024. Δ9-THC in cannabis is metabolized in the body and principally excreted in urine and feces as the metabolites Δ9-OH-THC, Δ9‐THC-COOH, and their glucuronide conjugates. <sup>1)</sup> Based on this, urine must be analyzed for these metabolites to prove cannabis use. This Application News investigated four methods of sample pretreatment that could be used to measure THC and its metabolites in urine and presents results obtained using the sample pretreatment method selected by this investigation in a quantitative analysis by GC-MS/MS (<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=GCMS-TQ+8040+NX"><strong>GCMS-TQ 8040 NX</strong></a> Triple Quadrupole Gas Chromatograph Mass Spectrometer).</p><h5><strong>Conclusions</strong></h5><p>This Application News investigated the simultaneous analysis of cannabis constituents Δ8-THC and Δ9-THC, and their metabolites Δ8-OH-THC, Δ9-OH-THC, Δ8-THC-COOH, and Δ9‐THC-COOH in urine. Four different extraction methods were tested for the sample pretreatment step. A liquid-liquid extraction method provided the best recovery among the four extraction methods tested and the optimized sample pretreatment workflow resulted in an analytical method with adequate sensitivity and quantitative accuracy. GC-MS/MS was used to create a method sensitive enough to readily detect target compounds at 1 ng/mL in urine that is suitable for the quantitative analysis of trace amounts of cannabis metabolitesin urine.</p><h4><strong>3. Thermo Fisher Scientific: Non-targeted analysis of whisky using SPME Arrow and </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/472"><strong>Orbitrap Exploris GC 240</strong></a><strong> mass spectrometer&nbsp;</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_003094_gc_hram_orbitrap_exploris_gc_240_whisky_an003094_na_en_46b10f592a.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Whisky is a premium alcoholic beverage based on the tradition built into its production. It consists of a cereal-water mixture or “mash”, which undergoes fermentation followed by distillation and cask maturation, creating a unique flavor profile over a long and complex aging process. Depending on the grain used, cask condition (new vs. old, charred vs. uncharred) and distillery process, significant variability in a whisky's chemical composition can occur. As a result of these distinguishing features, whisky is a sought-after commodity both for consumption and economic purposes, where investments in whisky have far outperformed stocks and other commodities such as gold in recent years.</p><p>In this study, the performance of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=Orbitrap+Exploris+GC+240"><strong>Orbitrap Exploris GC 240 high resolution accurate mass (HRAM) </strong></a><strong>mass spectrometer</strong> together with the headspace solid phase micro extraction (HS-SPME) for chemical profiling of whisky is demonstrated. With high mass accuracy (&lt;1ppm) and resolution capabilities (up to 240,000 mass resolution full width half maximum (FWHM) at m/z 200), the Orbitrap Exploris GC 240 mass spectrometer provides unsurpassed selectivity towards compound identification. Differences in chemical profiles are easily visualized using the statistical tools incorporated into the Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=Compound+Discoverer"><strong>Compound Discoverer</strong></a>™ software and a streamlined identification achieved using the Thermo Scientific Flavor and Fragrances HRAM library together with the NIST nominal mass library. Switching between electron impact (EI) and positive chemical ionization (PCI) for molecular ion identification/ confirmation is achieved quickly without system venting using the Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=NeverVent%E2%84%A2"><strong>NeverVent™</strong></a> technology. This provides analysts accurate identification of the chemical profile in whisky for product quality control and differentiates between whiskies suspected of fraudulent activities (e.g., additives and mislabeling).</p><h4><strong>Experimental conditions&nbsp;</strong></h4><h5><strong>Instrument and method setup&nbsp;</strong></h5><p>Headspace extraction and injection of whisky samples was performed using the Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=TriPlus%E2%84%A2+RSH+SMART"><strong>TriPlus™ RSH SMART autosampler</strong></a> equipped with the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=SMART+SPME+Arrow"><strong>SMART SPME Arrow</strong></a> 1.1 mm DVB/C-WR/PDMS fiber (P/N 36SA11T3-SM). Incubation and extraction were performed online followed by sample injection/ desorption. After sample injection, the SPME Arrow fiber was re-conditioned at high temperature under nitrogen using a SPME conditioning station to avoid sample carryover between injections. Further details surrounding the SPME Arrow operating parameters can be found in Table 1. A Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=TRACE%E2%84%A2+1610+GC"><strong>TRACE™ 1610 GC</strong></a> equipped with a Thermo Scientific™ TraceGOLD™ TG-624SilMS (30 m × 0.25 mm i.d. × 1.4 µm film) capillary column (P/N 26085-3320) was used to perform the chromatographic separation. Oven program conditions can be found in Table 1. Data acquisition was carried out in full scan analysis using both EI and PCI with the Orbitrap Exploris GC 240 mass spectrometer. Additional MS method parameters are summarized in Tables 2 and 3. External mass calibration was performed prior to analysis, while characteristic ions representing column bleed were used as lock masses when scanning in EI to perform internal mass calibration. Sample acquisition and qualitative processing were performed using Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=Chromeleon%E2%84%A2"><strong>Chromeleon™</strong></a> version 7.3.2 Chromatography Data System (CDS) software. Unknown analysis and identification were performed using Compound Discoverer version 3.3 software.</p><h4><strong>Conclusion</strong></h4><p>The complex and versatile chemical profile existing among the various whisky types causes challenges in identifying genuine and fraudulent whiskies. Targeted analytical approaches can be applied but cannot provide a complete picture of the chemical composition, potentially missing fraudulent clues. The combination of HS-SPME Arrow with Orbitrap Exploris GC HRAM capabilities provides rapid analysis of both targeted and untargeted compounds giving the following advantages:&nbsp;</p><ul><li>Time savings with minimal sample preparation and online extraction using the TriPlus RSH SMART robotic autosampler&nbsp;</li><li>Full scan acquisition at high mass resolution (i.e., 120 000 at m/z 200) providing targeted quantitative analysis with nontargeted chemical profile determination&nbsp;</li><li>Dedicated Flavor and Fragrances HRAM library enabling accurate identification at sub ppm mass accuracy&nbsp;</li><li>Mass spectral deconvolution combined with statistical tools for sample differentiation all combined within Compound Discover software</li></ul>

News from LabRulezGCMS Library - Week 11, 2025

Advancing characterization of pyrolysis products: Comprehensive gas chromatography methods for analytes in gas and liquid phases

<p><strong>In the week from March 17, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong data-start="0" data-end="81">1. Thermo Fisher Scientific: Unlocking Insights into PFAS in Food Analysis</strong></h5><ul data-start="84" data-end="139"><li data-start="84" data-end="122">Tuesday, March 18, 2025, 07:00 CET</li><li data-start="123" data-end="139"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4846">Registration</a></li></ul><p data-start="141" data-end="320">Join our webinar to gain expert insights into cutting-edge techniques, regulatory updates, and best practices for PFAS analysis in seafood, milk powder, and other food matrices.</p><h5><strong data-start="322" data-end="415">2. Thermo Fisher Scientific: Ready to go pesticide residue solution for faster results</strong></h5><ul data-start="418" data-end="473"><li data-start="418" data-end="456">Tuesday, March 18, 2025, 11:00 CET</li><li data-start="457" data-end="473"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4813">Registration</a></li></ul><p data-start="475" data-end="643">Join us for a webinar exploring a new ready-to-go pesticide residue analysis solution to ensure faster, more reliable data to ensure compliance with SANTE guidelines.</p><h5><strong data-start="645" data-end="698">3. Agilent Technologies: GC: Theory and Basics</strong></h5><ul data-start="701" data-end="756"><li data-start="701" data-end="739">Tuesday, March 18, 2025, 11:30 CET</li><li data-start="740" data-end="756"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4855">Registration</a></li></ul><p data-start="758" data-end="961">In the first of the GC and GC/MS: Theory, Maintenance, and Optimization Webinar Series, you will learn the theory of GC as well as the basics of hardware including set-up, function, and key components.</p><h5><strong data-start="963" data-end="1039">4. Agilent Technologies: Triglycerides analysis and ghee adulteration</strong></h5><ul data-start="1042" data-end="1099"><li data-start="1042" data-end="1082">Wednesday, March 19, 2025, 06:00 CET</li><li data-start="1083" data-end="1099"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4866">Registration</a></li></ul><p data-start="1101" data-end="1268">This live webinar focuses on triglyceride analysis in milk using GC in alignment with ISO 17678:2019 standards and discusses methods for detecting ghee adulteration.</p><h5><strong data-start="1270" data-end="1341">5. Wiley: Automate GC-MS Identification with KnowItAll MS Expert</strong></h5><ul data-start="1344" data-end="1401"><li data-start="1344" data-end="1384">Wednesday, March 19, 2025, 13:00 CET</li><li data-start="1385" data-end="1401"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4799">Registration</a></li></ul><p data-start="1403" data-end="1575">Learn how Wiley’s KnowItAll software can speed up the process and save hours of GC-MS manual analysis time by combining fast, flexible deconvolution with database search.</p><h5><strong data-start="1577" data-end="1702">6. Metrohm: Rethinking the quality control of polymers: The benefits of near-infrared and Raman spectroscopy explained</strong></h5><ul data-start="1705" data-end="1762"><li data-start="1705" data-end="1745">Wednesday, March 19, 2025, 16:00 CET</li><li data-start="1746" data-end="1762"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4825">Registration</a></li></ul><p data-start="1764" data-end="1918">Understand the specific strengths of NIR and Raman spectroscopy for polymer analysis and why these technologies are complementary in their capabilities.</p><h5><strong data-start="1920" data-end="2014">7. Thermo Fisher Scientific: Advanced workflow for PAH analysis of smoke flavored foods</strong></h5><ul data-start="2017" data-end="2073"><li data-start="2017" data-end="2056">Thursday, March 20, 2025, 11:00 CET</li><li data-start="2057" data-end="2073"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4756">Registration</a></li></ul><p data-start="2075" data-end="2240">Join this webinar to discover how proper sample prep, glass quality, and GC-MS/MS enable 1000x lower PAH detection in smoke-flavored foods to meet new regulations.</p><h5><strong data-start="2242" data-end="2320">8. Agilent Technologies: GC: Preventive Maintenance And Troubleshooting</strong></h5><ul data-start="2323" data-end="2379"><li data-start="2323" data-end="2362">Thursday, March 20, 2025, 12:00 CET</li><li data-start="2363" data-end="2379"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4856">Registration</a></li></ul><p data-start="2381" data-end="2581">During the second part of the GC and GC/MS Webinar Series, we will present the main preventive maintenance operations as well as how to keep your instrument up and running to its maximal capacities.</p>

Webinars LabRulezGCMS Week 12/2025

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Webinars LabRulezGCMS Week 12/2025

Advancing characterization of pyrolysis products: Comprehensive gas chromatography methods for analytes in gas and liquid phases

News from LabRulezGCMS Library - Week 11, 2025

Webinars LabRulezGCMS Week 11/2025

Liquid and gas-chromatography-mass spectrometry methods for exposome analysis

News from LabRulezGCMS Library - Week 10, 2025

Webinars LabRulezGCMS Week 10/2025

Ionic liquid coating for stir bar sorptive extraction and its application for extraction and nontargeted screening analysis via TD-GC–Orbitrap-HRMS of pollutants in river water

News from LabRulezGCMS Library - Week 9, 2025

Webinars LabRulezGCMS Week 9/2025

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