<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1007">NGA Extension</a> is a software module for natural gas and liquefied petroleum gas data processing. You no longer need an external tool for gas properties calculations since Clarity contains the complete workflow of data acquisition, peak calibration, reporting, and gas properties calculations based on supported norms. It is possible to perform summary calculations of gas properties from multiple signals and chromatograms.<ul><li>Calculates gas properties in compliance with internationally recognized standards ISO 6976-95, ASTM D 3588-98, GPA 2172-09 for Natural Gas or ASTM D 2421-02, ASTM D 2598-02, ISO 8973-97 / EN589-04 for Liquefied Petroleum Gas.</li><li>The gas properties can be calculated across multiple signals and even across multiple chromatograms.</li><li>It is possible to include additional norms based on customers feedback.</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=58&amp;search=NGA">NGA Extension</a> is an optional addition to <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/999">Clarity software</a>, it cannot be used as a standalone program.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Clarity_NGA_Extension_a32a83147a.jpg" alt="DataApex -Clarity NGA Extension" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Clarity_NGA_Extension_a32a83147a.jpg 245w," sizes="100vw" width="1212" height="767"><h4>Features - calculated properties according to norms</h4><h5>ISO 6976-95</h5><ul><li>Compression Factor (for real gas only)</li><li>Mean Molecular Weight</li><li>Relative Density</li><li>Density</li><li>Superior Calorific Value</li><li>Inferior Calorific Value</li><li>Wobbe Index</li></ul>ISO 6976-16 / ISO 6976-95 Natural gas: Calculation of calorific values, density, relative density, and Wobbe index from composition.<h5>ISO 8973-97 / EN589-04</h5><ul><li>Absolute Vapour Pressure (for Molar and Mass Percent only)</li><li>Gauge Vapour Pressure (for Molar and Mass Percent only)</li><li>Octane Number</li></ul>ISO 8973-97 / EN 589+A1: Standards for calculation methods for density and vapor pressure in liquefied petroleum gases.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Clarity_software_NGA_Natural_Gas_Analysis_Extension_2_5effa3549d.jpg" alt="DataApex: Clarity software - NGA (Natural Gas Analysis) Extension" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Clarity_software_NGA_Natural_Gas_Analysis_Extension_2_5effa3549d.jpg 195w," sizes="100vw" width="1005" height="806"><h5>ASTM D 3588-98 and GPA 2172-09</h5><ul><li>Molar Mass</li><li>Molar Mass Ratio</li><li>Compressibility Factor</li><li>Relative Density</li><li>Ideal Heating Value (also in BTU - British Thermal Units)</li><li>Real Heating Value (also in BTU - British Thermal Units)</li></ul>ASTM D 3588-98: The standard practice for calculating heating values, compressibility factor, and relative density of gaseous fuels.GPA 2172-09: Calculation of gross/net heating values, relative density, and compressibility factor for natural gas mixtures from compositional analysis.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Clarity_software_NGA_Natural_Gas_Analysis_Extension_93e81ffce8.jpg" alt="DataApex: Clarity software - NGA (Natural Gas Analysis) Extension" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Clarity_software_NGA_Natural_Gas_Analysis_Extension_93e81ffce8.jpg 176w," sizes="100vw" width="1023" height="905"><h5>ASTM ASTM D 2421-02 and D 2598-02</h5><ul><li>Vapor Pressure</li><li>Relative Density</li><li>Motor Octane Number</li></ul>ASTM D 2421-02: The standard practice for interconversion of analysis of C5 and lighter hydrocarbons to gas-volume, liquid-volume, or weight basis.ASTM D 2598-02: The standard practice for calculation of certain physical properties of liquefied petroleum (LP) gases from compositional analysis.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Clarity_software_NGA_Natural_Gas_Analysis_Extension_3_6e44e2d279.jpg" alt="DataApex: Clarity software - NGA (Natural Gas Analysis) Extension" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Clarity_software_NGA_Natural_Gas_Analysis_Extension_3_6e44e2d279.jpg 176w," sizes="100vw" width="853" height="757"><h4>Specification</h4><ul><li>Part No.: A32</li><li>Related products: Clarity (p/n C50)<ul><li>Clarity Offline (p/n C59) GC and AS Control module (p/n A23 and A26)</li></ul></li></ul>

Clarity software - NGA (Natural Gas Analysis) Extension

<div><div id=""><div><div><div><div>Extension for Detailed Hydrocarbon Analysis. It allows the determination of individual components in spark ignition engine fuels.</div></div></div></div></div></div><div><div id=""><div><div><div><div><div>DHA Extension brings you the ability to calculate the properties of the samples directly in the chromatography software with the complete workflow of data acquisition, peak calibration, DHA calculations based on supported norms and reporting. These methods are often referred to as PONA, PIONA, O-PONA, etc.Calculations in the DHA Extension currently support the ASTM D-6730 standard and methods developed by Dani Instruments SA.<figure class="image"><img style="aspect-ratio:1151/879;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_2_edfc9ba1f3.jpg" alt="DataApex: DataApex Clarity DHA (Detailed Hydrocarbon Analysis) Extension" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_2_edfc9ba1f3.jpg 204w," sizes="100vw" width="1151" height="879"></figure></div></div></div></div></div></div></div>You can create an additional custom method based on your own laboratory condititions or we can implement a standard method as part of the DHA extension at your request.If you request to implement another norm in the DHA Extension, please contact us at <a href="mailto:support@dataapex.com">support@dataapex.com</a>.The DHA Extension is optional and it can only be used together with <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/999">Clarity</a>.Note that for more complex DHA calculations, Clarity DHA Extension should be complemented by specialized software (e.g. Dragon II DHA© - see the <a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/downloads/26175/view">D151 datasheet</a> for more details).The DHA Extension is an optional fully integrated addition to <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/999">Clarity software</a>. It can be ordered as part of a new installation or as an extension to an existing one. There are two variants to this extension:<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_bc1e53cf67.jpg" alt="DataApex: DataApex Clarity DHA (Detailed Hydrocarbon Analysis) Extension" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_bc1e53cf67.jpg 211w," sizes="100vw" width="1223" height="906"><h5>p/n A33</h5><ul><li>includes general ASTM-D6730 standard method and the possibility to create custom method.</li></ul><h5>p/n A331</h5><ul><li>includes additional methods developed by DANI Instruments S.p.A</li></ul><h3 data-start="49" data-end="78">Norms specification</h3><h4 data-start="80" data-end="102">ASTM D-6730</h4><ul data-start="103" data-end="302"><li data-start="103" data-end="127">Included in p/n A33.</li><li data-start="128" data-end="302">Standard Test Method for Determination of Individual Components in Spark Ignition Engine Fuels by 100-Metre Capillary (with Precolumn) High-Resolution Gas Chromatography.</li></ul><h4 data-start="304" data-end="328">Custom Method</h4><ul data-start="329" data-end="441"><li data-start="329" data-end="353">Included in p/n A33.</li><li data-start="354" data-end="441">Allows you to create a custom method which meets the conditions in your laboratory.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_3_f5e659a432.jpg" alt="DataApex: DataApex Clarity DHA (Detailed Hydrocarbon Analysis) Extension" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_3_f5e659a432.jpg 245w," sizes="100vw" width="1233" height="756"><h4>ASTM D-6730 by DANI</h4><ul data-start="478" data-end="578"><li data-start="478" data-end="535">Method by Dani Instruments SA with cryogenic cooling.</li><li data-start="536" data-end="578">Available only at Dani Instruments SA.</li></ul><h4 data-start="580" data-end="619">ASTM D 2421-02 and D 2598-02</h4><ul data-start="620" data-end="720"><li data-start="620" data-end="677">Method by Dani Instruments SA with cryogenic cooling.</li><li data-start="678" data-end="720">Available only at Dani Instruments SA.</li></ul><h4>Extension specification</h4><ul data-start="761" data-end="911"><li data-start="761" data-end="782">Part No.: A33</li><li data-start="783" data-end="911">Related products:<ul data-start="811" data-end="911"><li data-start="811" data-end="832"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/999">Clarity</a> (p/n C50)</li><li data-start="835" data-end="864"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1000">Clarity Offline</a> (p/n C59)</li><li data-start="867" data-end="911">GC or AS Control module (p/n A23 or A26)</li></ul></li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_2_d15379bcdf.jpg" alt="DataApex: DataApex Clarity DHA - Detailed Hydrocarbon Analysis Extension" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Clarity_DHA_Detailed_Hydrocarbon_Analysis_Extension_2_d15379bcdf.jpg 245w," sizes="100vw" width="1995" height="1182">

DataApex Clarity DHA (Detailed Hydrocarbon Analysis) Extension

We are pleased to announce that a maintenance release is now available for KnowItAll 2025.Maintenance releases are an important way to introduce improvements and bug fixes between major releases to make sure users get the most out of KnowItAll solutions.Late 2024, we announced the KnowItAll 2025 major release featuring the new LC Expert tool, KnowItAll Data Control, KnowItAll Drug Classification Models, and various advances for spectral analysis workflows. This is the first update available after that release.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Know_It_All_LC_Expert_Streamline_component_identification_with_the_power_of_the_new_Know_It_All_LC_Expert_s_automated_workflow_84a090a7c2.jpg" alt="Wiley: NEW! KnowItAll LC Expert: Streamline component identification with the power of the new KnowItAll LC Expert’s automated workflow." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Know_It_All_LC_Expert_Streamline_component_identification_with_the_power_of_the_new_Know_It_All_LC_Expert_s_automated_workflow_84a090a7c2.jpg 245w," sizes="100vw" width="1735" height="960"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Know_It_All_drug_classification_models_25277cc5e0.jpg" alt="Wiley: NEW! KnowItAll drug classification models." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Know_It_All_drug_classification_models_25277cc5e0.jpg 245w," sizes="100vw" width="603" height="324">We encourage users to ensure they are using the most recent version of the software for best performance.<blockquote>Current users can <a target="_blank" rel="noopener noreferrer" href="https://get.knowitall.com/Download?_gl=1*18h0vjr*_gcl_au*Mjk3ODY0Mzg1LjE3MTMyNzcyMDEuMTkwNDkyNDI4NS4xNzEzMzY3NDc0LjE3MTMzNjc0Nzk.">download the most recent version here</a>.</blockquote><h4>Learn more about KnowItAll 2025:&nbsp;&nbsp;</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/whats-new-in-knowitall-2025/">What's New&nbsp;</a> &nbsp;&nbsp;</li><li><a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/knowitall-version-history/">Version History</a></li></ul><h4>About KnowItAll</h4>KnowItAll Software offers solutions to analyze and manage multiple types of spectral and chemical data in multiple file and instrument formats. KnowItAll's integrated toolsets eliminate the need for multiple software packages and increase overall lab efficiency and staff proficiency. Combined with Wiley’s comprehensive, high-quality spectral reference libraries, it provides an unparalleled solution for fast, reliable spectral analysis.<h4>About Wiley</h4>Wiley (NYSE: WLY) is one of the world’s largest publishers and a trusted leader in research and learning. Our industry-leading content, services, platforms, and knowledge networks are tailored to meet the evolving needs of our customers and partners, including researchers, students, instructors, professionals, institutions, and corporations. We empower knowledge-seekers to transform today’s biggest obstacles into tomorrow’s brightest opportunities. For more than two centuries, Wiley has been delivering on its timeless mission to unlock human potential. Visit us at <a target="_blank" rel="noopener noreferrer" href="https://www.wiley.com/en-ie">Wiley.com</a>.&nbsp;

KnowItAll 2025 Maintenance Release 2025.1 Available

Wiley, one of the world’s largest publishers and a global leader in research and learning, announced the 2025 release of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/940">Mass Spectra of Designer Drugs</a>.This database is a critical asset for forensic laboratories around the globe, facilitating rapid identification of illicit substances. Compiled from both legal and underground sources, it offers access to the latest novel psychoactive substances (NPS) like variants of fentanyl, xylazine, various opioids, synthetic cannabinoids, and more.Annually updated, this GC-MS database provides access to 36,360 spectra, representing 27,500 unique chemical entities, along with detailed information and chemical structures.&nbsp;<blockquote>This year’s update introduces over 1,260 new spectra and over 780 unique compounds in major categories of interest.</blockquote>“Forensic laboratories require up-to-date databases to stay ahead of emerging NPS trends. This resource remains crucial in the ongoing battle against drugs.” said Graeme Whitley, director, data science solutions at Wiley.The Mass Spectra of Designer Drugs database is compatible with most major mass spectrometry data systems. Additionally, it is available as a KnowItAll subscription, integrating with Wiley's KnowItAll spectral analysis software, which features automated non-targeted analysis, including feature detection, automatic deconvolution, and library search in a single touch. It also includes tools for identifying novel compounds, such as drug classification models and a patented MS Adaptive Search tool that provides tremendous insight into structural possibilities when there is no exact match.<blockquote>Learn more <a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/solutions/technique/gc-ms/mass-spectra-of-designer-drugs/">HERE</a></blockquote><h4>About Wiley</h4>Wiley (NYSE: WLY) is one of the world’s largest publishers and a trusted leader in research and learning. Our industry-leading content, services, platforms, and knowledge networks are tailored to meet the evolving needs of our customers and partners, including researchers, students, instructors, professionals, institutions, and corporations. We empower knowledge-seekers to transform today’s biggest obstacles into tomorrow’s brightest opportunities. For more than two centuries, Wiley has been delivering on its timeless mission to unlock human potential. Visit us at <a target="_blank" rel="noopener noreferrer" href="https://www.wiley.com/en-ie">Wiley.com</a>.&nbsp;

Wiley releases Mass Spectra of Designer Drugs 2025 – an essential resource for forensic laboratories

<h3>Introduction</h3>This document presents:<ul><li>a comparison of integration algorithms (IAs) available in <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/999">Clarity</a>,</li><li>a generally proposed workflow for integrating chromatograms,</li><li>description of functions that are available only in the Wave algorithm.</li></ul>Integration algorithms are a crucial component of any chromatography software. They identify peaks in a raw chromatographic curve, assign integration marks (starts, ends, apexes), and determine the peak baseline. Although it is the operator's responsibility to verify the correct peak integration after the analysis is finished, an automated peak detection facilitated by the integration algorithm can significantly streamline the workflow.Clarity since version 9.0 offers two IAs: the original algorithm, renamed Legacy, and a newly introduced algorithm named Wave, which evolved from an experimental algorithm present since version 7.0. The Wave algorithm will be regularly updated with new functions, settings, and bug fixes (updates for Legacy will only be released if a critical bug is discovered). Changes in IAs are always versioned and distinguishable by records in the audit trail.<h3>Choosing an integration algorithm</h3>Users can select either the Legacy or Wave integration algorithm for peak detection. The IA drop-down selection has been relocated to the Integration tab in both the Chromatogram window and the Method Setup dialog, highlighting the interconnection between the algorithm and the integration table.The introduction of Wave does not affect existing results or methods, as they will remain set to Legacy unless manually altered. Suppose a method was created using an older version of any integration algorithm and was not changed after the Clarity update to a newer version. In that case, the latest version of the same algorithm will be used in any newly measured chromatograms. This change will be logged in these chromatograms upon creation. To address potential issues, DataApex aims to use the algorithm version with the most bug fixes. Users are not required to re-save their methods, but if they do, the change will be logged in the method audit trail.One way to apply an integration algorithm to multiple chromatograms simultaneously is through the Batch dialog (not applicable to Clarity Lite).<h3>General Comparison</h3>Neither algorithm can be universally deemed superior; some situations may warrant using one IA over the other. Below are some examples of performance differences between the two IAs. At least the Global Peak Width and Global Threshold operations were presumed to be performed on the signal. If you encounter any issues with either of the integration algorithms, please inform DataApex via <a>support@dataapex.com</a>. This datasheet further contains an overview of a basic integration workflow.<h4>Advantages of Wave IA:</h4><ul><li>Handling of negative spikes/peaks with regard to baseline placement.</li><li>Handling of shifting baseline/signal.</li><li>Separation of unresolved peaks.</li></ul><h4>Disadvantages of Wave IA:</h4><ul><li>More sensitive to noise, requiring the use of Bunching or another filter in some cases.</li><li>Incorrect integration when peaks of significantly different widths are present (typical for GPC or EA).</li></ul><h4>Negative spikes/peaks</h4>When a chromatogram contains significant negative peaks or spikes that should not be evaluated, the default integration in the Wave algorithm will produce satisfactory results, while the Legacy algorithm will not. (In Legacy, this problem could be solved by applying several Integration Intervals.)<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_4b4372d5b8.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 1. Integration by Legacy IA considers the negative spike to be the start of the peak (or peak cluster)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_4b4372d5b8.jpg 245w," sizes="100vw" width="1063" height="548"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_11_e51da3eb48.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 2. Integration by Wave IA with the same parameters." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_11_e51da3eb48.jpg 245w," sizes="100vw" width="1061" height="554"><h4>Shifting signal/baseline</h4>Similar to the negative peaks/spikes, the same situation may arise with a shifting baseline where the peaks should be evaluated to that baseline. Legacy IA will provide unsatisfactory integration. In Legacy, this could be solved by applying Baseline Valley to several places and combining them with Integration Interval.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_13_d44f34c303.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 3. Integration by Legacy IA." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_13_d44f34c303.jpg 245w," sizes="100vw" width="1064" height="551"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_14_8c3d2772fe.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 4. Integration by Wave IA with the same parameters. The fairly high number of peaks is caused by the low value of the Global Threshold." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_14_8c3d2772fe.jpg 245w," sizes="100vw" width="1062" height="553"><h4>Unresolved Peaks</h4>In Legacy IA, if a peak does not fulfill some criteria (it is too narrow or the valley to other non-resolved peaks is too low), it gets joined to a neighboring bigger peak. Meanwhile, Wave IA evaluates the valley depths much better and separates the peaks automatically, even when the small peak does not fulfill some of the criteria. Small impurities, thus, do not influence the area of the bigger peak of interest.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_10_49fded9390.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 5. Integration by Legacy IA." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_10_49fded9390.jpg 245w," sizes="100vw" width="1062" height="554"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_12_6d8d9a6980.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 6. Integration by Wave IA with the same parameters." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_12_6d8d9a6980.jpg 245w," sizes="100vw" width="1062" height="551"><h4>Significant noise</h4>In some cases, the signal noise may be very significant, and the set threshold value in the Wave algorithm will be so low that one peak will be split into several peaks. The example below shows that neither of the IAs is sufficient with just Global Peak Width and Global Threshold; additional operations must be used.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_9_e020e43a49.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 7. Integration by Legacy IA with the same parameters." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_9_e020e43a49.jpg 245w," sizes="100vw" width="1062" height="552"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_8_1b275412a8.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 8. Integration by Wave IA." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_8_1b275412a8.jpg 245w," sizes="100vw" width="1064" height="552"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_7_4071029dd3.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 9. Integration by Wave IA after applying Global Bunching. Sometimes, small peaks at the start/end of a bigger one may remain." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_7_4071029dd3.jpg 245w," sizes="100vw" width="1061" height="550"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_6_ee88c557f1.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 10. Integration by Wave IA after applying Global Bunching and Minimal Area parameters." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_6_ee88c557f1.jpg 245w," sizes="100vw" width="1063" height="556"><h4>Peaks with significantly different peak widths</h4>Sometimes, chromatograms have very different peak widths; when some peaks cover a significant portion of the chromatogram (e.g., in EA or GPC), Wave IA may fail to evaluate the wide peaks properly. Currently, it is recommended to integrate these chromatograms using Legacy IA.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_3_b833975244.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 11. Integration by Legacy IA with the same parameters." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_3_b833975244.jpg 245w," sizes="100vw" width="1060" height="549"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_4_660685f241.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 12. Integration by Wave IA." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_4_660685f241.jpg 245w," sizes="100vw" width="1060" height="551"><h4>Peaks cut off in the middle</h4>Sometimes, random peaks get integrated strangely in Wave IA, being cut off. This happens only randomly in the Wave IA (in a series of chromatograms, most peaks are OK, but occasional chromatograms may have one or more peaks cut off). The phenomenon results from filtering the data in combination with the signal curve course. There is no 100% solution in the Wave algorithm (applying Global Bunching or other filters helps in most cases). Switching to Legacy IA helps.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_2_ce68c8dc99.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 13. Integration by Wave IA." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_2_ce68c8dc99.jpg 245w," sizes="100vw" width="1064" height="553"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_5_af9302130f.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 14. Integration by Wave IA after applying Global Bunching." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_5_af9302130f.jpg 245w," sizes="100vw" width="1061" height="549"><h3>Basic integration workflow</h3>Setting at least the Integration Interval and global parameters before resorting to other operations is recommended. This strategy suffices for most chromatograms, and such integration is then applicable to all similar samples. The recommended order of operations is as follows (refer to the User Guide for a detailed description):<ol><li>Set Integration Interval(s) Some areas of the chromatograms are irrelevant to the analysis and may cause wrong integration of the rest of the chromatogram if left in operation, e.g., sudden steep signal rises/drops when lamps are switched on, mobile phase compositions suddenly changing, etc. Make sure that the Integration Interval operation does not define an interval starting or ending inside of a peak slope; in either IA, the expectation is that the chromatogram starts and ends on a baseline.</li><li>Set Global Peak Width If the chromatogram has peaks with significantly differing peak widths, applying the Local Peak Width operation may be useful later.</li><li>Use Global Bunching operation Global Bunching is calculated based on the chromatogram frequency and the set Global Peak Width, so it should be applied after setting the Global Peak Width.</li><li>Set Global Threshold Based on the Threshold value, the smallest peaks are omitted depending on the noise of the signal curve. Since Global Bunching acts as a signal filter, the automatically suggested Global Threshold value will differ after applying Global Bunching higher than 1.</li></ol><h3>Exclusive features in Wave IA</h3>Wave IA contains some Integration Table functions that are unavailable in Legacy IA. If these functions are present in the Integration Table, they will become invisible (not performed) when switching to the Legacy IA but will remain if the algorithm reverts to Wave.<h4>Peak – Show and Peak – Hide</h4>The Peak – Show and Peak – Hide functions provide a convenient way to manage the visibility of specific peaks in your data. These tools allow you to tailor your display by either showing or hiding specific peaks.By default, the Wave algorithm might automatically ignore some of the minor peaks identified during integration. However, completely eliminating these peaks could potentially affect the baseline's trajectory. Therefore, these functions offer a flexible way to handle unwanted peaks without completely removing them.Both the Peak – Show and Peak – Hide features are complemented by the Baseline – Lock function. This tool completely removes all peaks that have their maxima within a set time interval. This could affect other peaks with maxima outside the specified window, particularly if they share the same baseline.The Peak – Hide function has been designed within the Wave algorithm to address this. It merely hides peaks within the selected time interval instead of eradicating them. These peaks are considered when constructing a joint baseline but excluded from the final calculation and the Result Table. The counterpart function Peak - Show allows you to visualize a previously hidden peak or display peaks automatically hidden by the algorithm.In scenarios where a region of the chromatogram contains hidden peaks and the user executes the Peak – Add Positive/Negative operation, all automatically generated but concealed peaks within the defined time interval are replaced by the newly added peak. This could lead to the cancellation of hidden peaks in areas where the manually added peak is not displayed due to baseline crossing limitations.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Integration_Algorithms_in_Clarity_15_b934973f35.jpg" alt="DataApex: Integration Algorithms in Clarity: Figure 15. Difference between Peak Hide (left) and Baseline Lock (right)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Integration_Algorithms_in_Clarity_15_b934973f35.jpg 245w," sizes="100vw" width="1830" height="285"><h4>Global/Local Baseline Slope</h4>Automatic peak generation on a standard signal curve typically comprises three parts: Peak Start, Peak Apex, and Peak End. The highest signal point determines the location of Peak Apex. At the same time, the positioning of Peak Starts and Peak Ends can vary, potentially being either closer or farther from the Peak Apex, based on user preference. Different settings can be more effective depending on the situation.Before the introduction of the Wave IA, the automatic determination of Peak Starts and Peak Ends was governed by the instantaneous peak slope, calculated using the Global/Local Threshold parameter. If users wanted the automatically generated peak borders closer to the Peak Apex, they had to increase the Threshold value. However, this resulted in raising the detection limit for peaks on the baseline, which could prevent the identification of smaller peaks.Wave IA presents an alternative. It allows users to maintain their chosen Threshold value while separately defining the chromatographic curve slope for detecting Peak Starts and Peak Ends through the use of the Global Baseline Slope or Local Baseline Slope operations. This parameter is not mandatory; users can retain the original slope calculation method by leaving the Global Baseline Slope value set to 0. Any value other than zero will cause a shift in the positions of the Peak Starts and Peak Ends.You can find an approximate value for this function using the Chromatogram – Show Slope/Level function in the Chromatogram window menu. However, altering the Baseline Slope value may result in separating peak clusters into individual peaks or merging separate peaks, and some peaks may not be integrated at all.For specific alterations to the start and/or end positions of individual peaks, the Peak – Start and Peak – End operations remain useful. These functions override the automatically calculated positions for peak start and peak end.

Integration Algorithms in Clarity

Clarity 10.1 expands calibration capabilities to help you work more confidently and efficiently. From clearer guidance and better warnings to flexible internal standard evaluation, this update streamlines calibration development, improves traceability, and supports compliance where it matters most.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Clarity_10_1_397aba9bab.jpg" alt="DataApex: Clarity 10.1 released" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Clarity_10_1_397aba9bab.jpg 143w," sizes="100vw" width="849" height="925"><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/labrulez-bucket-strapi-h3hsga3/P063_Clarity_10_1_New_Features_283323fcd2.pdf">Clarity 10.1 highlights</a></h4><ul><li>ISTD from a different signal</li><li>Determination Coefficient (R2)</li><li>Enhanced calibration warnings and blank handling</li><li>Electronic Signature improvements</li><li>New and updated control modules</li></ul><h5>Internal standard from another signal</h5>Clarity 10.1 introduces support for evaluating results using an internal standard from a different signal within the same chromatogram. This is especially useful for workflows like ICP-MS, where some signals may lack an ISTD peak.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Internal_standard_from_another_signal_2f2ac068f8.jpg" alt="DataApex: Internal standard from another signal" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Internal_standard_from_another_signal_2f2ac068f8.jpg 228w," sizes="100vw" width="380" height="260"><h5>Determination Coefficient (R²)</h5>Clarity now displays the Determination Coefficient (R²) alongside the Correlation Coefficient in each compound's calibration curve tab.Determination Coefficient (R²) gives you a more accurate view of how well your calibration model fits the data - especially valuable during method development and validation.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Determination_Coefficient_57673d0ac3.jpg" alt="DataApex: Determination Coefficient" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Determination_Coefficient_57673d0ac3.jpg 228w," sizes="100vw" width="380" height="260"><h5>Enhanced calibration warnings and blank handling</h5>Clarity 10.1 helps you catch issues earlier and set up calibration with greater confidence. Warnings are now more visible and more specific - appearing above both the Results Table and the Calibration Summary Table. When multiple issues occur, an ellipsis appears with full details available on hover.Blank handling has also been clarified: blanks are included only when Ignore Origin is selected. If the origin is used, blanks are excluded, and Clarity now clearly warns and visually shows when a blank is ignored.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Dataapex_Enhanced_calibration_warnings_and_blank_handling_e9fe7fa31e.jpg" alt="Dataapex: Enhanced calibration warnings and blank handling" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Dataapex_Enhanced_calibration_warnings_and_blank_handling_e9fe7fa31e.jpg 228w," sizes="100vw" width="380" height="260"><h5>Signature improvements</h5>Clarity 10.1 improves how signatures are handled, making it easier to understand what is and isn't signed. Chromatograms opened with a linked calibration are always marked Not Signed. Once signed, the mode switches to Stored Calibration, so you always see the final, signed result. Even historical versions now reliably show their signature state and details.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Dataapex_Signature_improvements_a2bebe7875.jpg" alt="Dataapex: Signature improvements" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Dataapex_Signature_improvements_a2bebe7875.jpg 228w," sizes="100vw" width="380" height="260"><blockquote>Explore the complete list of all changes, fixes, and additions in version 10.1.<a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1">See the complete changelog</a></blockquote>

Clarity Chromatography Software 10.1 released!

<h4>Calculation of biodiesel composition can be done directly in Clarity</h4>This whitepaper explains how to calculate the content of fatty acid methyl esters (FAME) and the linoleic acid methyl ester in biodiesel fuel according to ISO 14103 in Clarity. As stated in the norm, the content of FAME in biodiesel is greater than 90 % (m/m), while the content of the linoleic acid methyl ester is between 1 % and 15 % (m/m). The methyl esters in FAME should be between C14 and C24.<h4>Principle</h4>The determination of the content of FAME employs internal calibration (ISTD – methyl heptadecanoate). The ester content in m/m percent is calculated as:<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Determining_biodiesel_composition_according_to_ISO_14103_2_f900384c97.jpg" alt="DataApex: Determining biodiesel composition according to ISO 14103." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Determining_biodiesel_composition_according_to_ISO_14103_2_f900384c97.jpg 245w," sizes="100vw" width="1064" height="85">where 𝐶 is the ester content, ∑ 𝐴 is the total peak area of the methyl esters from C14 to C24, 𝐴ISTD is the peak area of the ISTD compound, 𝐶ISTD is the concentration of ISTD (in mg/ml), 𝑉ISTD is the volume of ISTD (in ml), 𝑚ISTD is the mass of ISTD (in mg), and 𝑚 is the mass of the sample (including ISTD mass; in mg).The linoleic acid methyl ester content in m/m percent is given as:<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Determining_biodiesel_composition_according_to_ISO_14103_3_1a356fc1f5.jpg" alt="DataApex: Determining biodiesel composition according to ISO 14103." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Determining_biodiesel_composition_according_to_ISO_14103_3_1a356fc1f5.jpg 245w," sizes="100vw" width="1064" height="85">where 𝐿 is the linoleic acid methyl ester content, ∑𝐴 is the total peak area of the methyl esters from C14 to C24, 𝐴ISTD is the peak area of ISTD, and 𝐴𝐿 is the peak area corresponding to the linoleic acid methyl ester.<h4>Preparing chromatogram and calibration</h4>After measuring your sample, open your chromatogram in <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/999">Clarity</a>. Group the FAME peaks using the Peak Groups… function (menu Chromatogram – Peak). In the Groups dialog, set an ID, click Add, and select the corresponding peaks. In the example chromatogram (download link below), Group A (FAME) does not contain the ISTD peak – this simplifies the subsequent calculations.Create a new calibration and open the sample chromatogram as a standard. In the Calibration Options, change the Display Mode to ISTD and Mode to Recalibrate. Use the Add Peak function to add the ISTD (methyl heptadecanoate) peak and linoleic acid peak to the calibration. In the Amount column, write the known ISTD amount. To add the group of FAME peaks, use the Add Group function. Then, on the linoleic acid and FAME compound tabs, set the Calculate By option to the ISTD compound name. Save the calibration and link it to the sample chromatogram. To improve clarity, in the Common for All Signals pane, select the All Identified Peaks option in the Report in Result Table section.<h5>Procedure for calculation of FAME content</h5>The desired results can be calculated directly in Clarity using the User Columns: right click anywhere in the Result Table pane in the Results tab of the Chromatogram window and select User Columns – Add… in the context menu. In the Add User Column dialog, fill in the Title and Units (e.g. FAME in %) and uncheck the Calculate Total checkbox. The following expression can be used to calculate the FAME content, if the ISTD peak was not included in the FAME peak group:([FAME$Area] / [ISTD$Area]) * ([ISTD1 Amount] / ([Sample Amount] + [ISTD1 Amount]))*100If the ISTD peak was included in the FAME peak group, its area must be subtracted from the area of the FAME group:(([FAME$Area] - [ISTD$Area]) / [ISTD$Area]) * ([ISTD1 Amount] / ([Sample Amount] + [ISTD1 Amount]))*100<h5>Procedure for calculation of the linoleic acid methyl ester content</h5>Calculation of linoleic acid methyl ester content is analogous to calculation of the FAME content. Add another user column, fil in the Title and Units (e.g., Linoleic Acid in %) and uncheck the Calculate Total checkbox. If the ISTD peak was not included in the FAME peak group, the following expression can be used:[Linoleic acid$Area] / [FAME$Area]*100Analogously, if the ISTD peak was included in the FAME group, it must be subtracted:[Linoleic acid$Area] / ([FAME$Area] - [ISTD$Area])*100<h4>Example of an evaluated chromatogram</h4><h4>Sample data for Clarity</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://downloads.dataapex.com/documentation/clarity/other/Biodiesel.zip">Biodiesel.zip</a> – zipped processed chromatogram and calibration.</li></ul>

Determining biodiesel composition according to ISO 14103

Clarity's Dual Chromatogram Mode is a specialized configuration designed for analytical systems that require simultaneous acquisition and processing of data from multiple detectors. Most commonly applied in dual tower gas chromatograph (GC) systems, this mode allows for the real-time acquisition of two chromatograms - each representing distinct detector outputs.This guide provides an in-depth look into the configuration, operational mechanics, and benefits of using Dual Chromatogram Mode within <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/999">Clarity software</a> by DataApex.<h4>Tools and System Requirements</h4><h5>Prerequisites</h5><ul><li>Clarity Chromatography Software</li><li>Dual Detector System (e.g., Dual Tower GC)</li><li>Properly configured System Configuration files</li><li>Signal Channels connected to respective detectors</li></ul><h4>System Configuration and Activation</h4><h5>Enabling Dual Chromatogram Mode</h5>To enable this mode, the user must access the System Configuration settings and individually activate Dual Chromatogram Mode for each instrument. This configuration determines how signal inputs from multiple detectors are routed.<h5>Assigning Signals</h5>Once activated:<ul><li>Signals are split and assigned to either the Front or Back chromatogram.</li><li>This signal labeling is consistent throughout the Clarity software workflow, ensuring accurate data mapping and separation.</li></ul><h4>Method Setup and Calibration</h4><h5>Method Adaptation</h5>Each method needs to be adapted to work with Dual Chromatogram Mode:<ul><li>Signals are distinctly labeled by position (Front/Back).</li><li>Each method tab includes separate configuration areas for each signal path.</li></ul><h5>Calibration Files</h5><ul><li>If calibration is used, individual calibration files must be assigned to the front and back chromatogram paths within the method settings.</li></ul><h4>Interface and Workflow Adjustments</h4><h5>Chromatogram and Instrument Windows</h5><ul><li>The Instrument Window is visually adapted to display both signal positions side by side.</li><li>The Chromatogram Window clearly labels which detector the chromatogram originated from by indicating position in the Measurement Conditions section.</li></ul><h5>Sequence Window Enhancements</h5><ul><li>Identification columns in the Sequence Window are designated separately for each chromatogram.</li><li>Other columns (like sample names, batch parameters) are shared and applied to both positions.</li></ul><h4>Reporting and Data Processing</h4><h5>Report Customization</h5><ul><li>Generated reports automatically include a dual mode label, indicating the chromatogram's origin (Front/Back).</li><li>All standard report formatting options remain supported.</li></ul><h5>Data Evaluation</h5><ul><li>The mode supports independent processing for each chromatogram.</li><li>All standard reprocessing operations—such as integration, calibration application, and result analysis - are supported independently for each position.</li></ul><h4>Conclusion</h4>Clarity’s Dual Chromatogram Mode offers robust functionality for dual-detector systems, providing synchronized acquisition while maintaining the independence of signal processing. This ensures analytical accuracy, ease of comparison, and flexible evaluation, especially in multi-detector chromatographic setups.<blockquote>For more information, see the Dual Chromatogram Mode manual:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.cz/paper/30514">Clarity Extension DUAL CHROMATOGRAM MODE</a></li></ul>For further learning, watch more instructional content on the:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@DataapexPrague">DataApex YouTube channel</a></li></ul></blockquote>

Dual Chromatogram Mode in Clarity: A Technical Overview

<h4>1. Introduction</h4>This article provides a comprehensive and structured troubleshooting guide for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity chromatography software </a>by DataApex. Based on the instructional video titled “What to do when you have issues with Clarity”, it outlines common errors, diagnostic methods, and recommended procedures for addressing technical problems in both software and hardware configurations.<h4>2. Required Tools and Environment</h4>To effectively troubleshoot Clarity, ensure you have access to the following:<ul><li>Clarity Software (version 9.x or 10.x)</li><li>Hardware key (HW key) – for license authorization</li><li>Windows administrator privileges</li><li>Connected instrumentation (GC/LC systems, A/D converters)</li><li>Diagnostic tools:<ul><li>Windows Event Viewer</li><li>Clarity Device Configuration Manager</li></ul></li></ul><h4>3. Common Errors and Solutions</h4><h5>3.1 File Access Errors</h5>Symptom:<ul><li>Error messages such as: "Unknown error accessing ... Temp\Clarity\$ch1run.raw"</li></ul>Cause:<ul><li>Lack of write permissions to the Temp directory.</li></ul>Solution:<ol><li>Ensure the Windows user has full access to the Temp\Clarity folder.</li><li>Run Clarity as Administrator to bypass restricted permissions.</li></ol><h5>3.2 Hardware Key Not Recognized</h5>Symptoms:<ul><li>"Clarity is unable to find HW key"</li><li>"Missing keylock drivers"</li><li>"Blocked HW key"</li></ul>Causes:<ul><li>Key not plugged in, damaged USB port, or missing driver.</li></ul>Solution:<ol><li>Reinsert the HW key into a direct USB port (avoid USB hubs).</li><li>If drivers are missing or outdated, reinstall the HW key drivers and restart the PC.</li><li>Contact DataApex support if the key is blocked or invalid.</li></ol><h5>3.3 Visual C++ Redistributable Installation Fails</h5>Error:<ul><li>"Exit code: 1618" during Clarity installation.</li></ul>Cause:<ul><li>Another installation is already running (e.g., Windows Update).</li></ul>Solution:<ul><li>Wait for the current installation to finish, restart the system, and rerun the Clarity installer.</li></ul><h5>3.4 Instrument Communication Failure</h5>Error:<ul><li>"Cannot establish communication with XXX SN xxx!"</li></ul>Possible Causes:<ul><li>Instrument is turned off or disconnected.</li><li>Wrong or missing driver.</li><li>Incorrect COM port or IP address.</li></ul>Solution:<ol><li>Power on the instrument and verify all connections.</li><li>Use Clarity → System Configuration → Devices to verify driver and port settings.</li><li>Restart the driver or reassign the port if needed.</li></ol><h5>3.5 RAW File Creation Errors</h5>Error:<ul><li>"Cannot create RAW file"</li><li>"Cannot create $ch1temp.raw"</li></ul>Cause:<ul><li>Clarity fails to rename the RAW file due to a file conflict or improper termination.</li></ul>Solution:<ul><li>Ensure the previous acquisition was closed properly.</li><li>Clear error dialogs and restart the acquisition.</li></ul><h5>3.6 Project Change Requires Restart</h5>Error:<ul><li>"Changing project requires to restart instrument."</li></ul>Solution:<ul><li>Save your changes and allow the instrument to restart as prompted.</li></ul><h5>3.7 Configuration File Corruption or Version Conflict</h5>Errors:<ul><li>"Configuration file is not valid"</li><li>"Incompatible device driver"</li></ul>Cause:<ul><li>Attempting to load a project or method created in a newer software version.</li></ul>Solution:<ol><li>Use backup files provided by Clarity.</li><li>Reconfigure devices manually if needed.</li><li>Install matching drivers compatible with your current Clarity version.</li></ol><h5>3.8 Method and Table Errors</h5>Common Issues:<ul><li>"Fraction table contains overlapping time intervals"</li><li>"Too many peaks in chromatogram"</li><li>"Method file does not match instrument configuration"</li></ul>Solution:<ul><li>Adjust fraction time intervals to prevent overlaps.</li><li>Tweak peak detection settings (width, threshold).</li><li>Modify or recreate the method to reflect hardware changes.</li></ul><h4>4. General Troubleshooting Workflow</h4><ol><li>Reboot your PC – resolves many temporary issues.</li><li>Check file and folder permissions – especially the Temp and project directories.</li><li>Verify hardware connections – including USB and serial ports.</li><li>Update or reinstall drivers – HW key, devices, or Clarity modules.</li><li>Restore from backups – when configuration or method files are corrupted.</li></ol><h4>5. Analysis and Best Practices</h4><ul><li>70% of reported issues are related to permissions, HW key problems, or outdated drivers.</li><li>Always keep Clarity and related drivers updated from the official source.</li><li>Ensure project and method files are compatible with the Clarity version you are using.</li><li>Use administrative privileges when installing or configuring hardware/software.</li></ul><h4>6. Conclusion</h4>Clarity is a robust chromatography software platform, but like any system, it may encounter operational or configuration errors. This guide outlines practical and verified troubleshooting techniques derived from real-world scenarios shown in the DataApex tutorial video.For persistent or unclear issues, consult the DataApex Support Portal for documentation, driver downloads, and direct contact with technical support.<blockquote><h5>Quick Tips Recap</h5><ul><li>Always start with a reboot and check permissions.</li><li>Reinstall drivers if devices or keys are not recognized.</li><li>Use correct project/method versions matching your Clarity installation.</li></ul></blockquote>

Troubleshooting Guide: Resolving Issues with Clarity Chromatography Software

<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity</a> is a professional chromatography data system (CDS) developed by DataApex. This article provides a technical guide to how Clarity organizes and stores its files. You will learn about each key directory, the types of data stored, best practices for backup and transfer, and file dependencies that must be preserved.<h4>🗂️ Main Folder Structure</h4>Once Clarity is installed, several important folders are created within the installation directory:<h5>1. Bin Folder</h5><ul><li>Contains the Clarity software executable files and essential utilities:<ul><li>IQ (Installation Qualification)</li><li>Launch Manager</li></ul></li><li>No user modification or backup is needed here.</li></ul><h5>2. CFG (Configuration) Folder</h5><ul><li>Stores station configuration and user-specific settings.</li><li>Includes:<ul><li>Device configuration files</li><li>User layout files (.DSK)</li><li>Audit trails</li><li>Diagnostic data</li></ul></li><li>Essential for backup and station transfer.</li></ul><h5>3. DataFiles Folder</h5><ul><li>Stores all chromatographic measurement data.</li><li>Organized by projects—details provided in the next section.</li></ul><h5>4. Documentation Folder</h5><ul><li>Includes data sheets, user manuals, and relevant documents for the installed software version.</li></ul><h5>5. uninstall.exe</h5><ul><li>Used to uninstall Clarity from the system.</li></ul><h4>What Should Be Backed Up?</h4>When backing up or transferring a Clarity installation, it is critical to retain the following:<ul><li>The entire CFG folder – contains configuration, settings, and audit data.</li><li>The DataFiles folder – contains all project data and chromatograms.</li><li>Key files:<ul><li>configuration.cfg – station/device setup</li><li>desktop.dsk – user interface layout</li><li>clarity.psw – password storage</li></ul></li></ul><h4>Understanding the DataFiles Folder Structure</h4>Clarity uses a project-based architecture for storing measurement data. The structure of the DataFiles folder is as follows:Top-Level Contents of DataFiles<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Top_Level_Contents_of_Data_Files_ce779a1797.jpg" alt="DataApex: Table 1 Top-Level Contents of DataFiles" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Top_Level_Contents_of_Data_Files_ce779a1797.jpg 245w," sizes="100vw" width="1600" height="377">Inside a Project FolderEach project folder contains the following:<ul><li>Main project directory:<ul><li>Method files (*.met)</li><li>Sequence files (*.sqt)</li><li>SST files (*.sst)</li></ul></li><li>Subfolders (created by default):<ul><li>Calib – for calibration chromatograms and standards</li><li>Data – for unknown samples and bypass measurements</li></ul></li></ul>Users may create subfolders inside Calib and Data for better organization by date, sample type, etc.⚠️ Important: Do not create subfolders outside of Calib and Data. Improper structure may break internal file links and lead to system errors.<h4>📁 Example Files and Their Functions</h4><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Example_Files_and_Their_Functions_f1924494e5.jpg" alt="DataApex: Table 2 Example Files and Their Functions" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Example_Files_and_Their_Functions_f1924494e5.jpg 245w," sizes="100vw" width="1600" height="639"><h4>Best Practices</h4><ul><li>Regularly back up both CFG and DataFiles folders.</li><li>When transferring Clarity to a new PC:<ol><li>Install Clarity as usual.</li><li>Copy over the CFG and DataFiles folders.</li></ol></li><li>Avoid moving or editing files manually outside of permitted folders (Calib, Data).</li></ul><h4>Conclusion</h4>Proper file management in Clarity ensures a stable and reliable workflow. By following the recommended folder structure and backup strategy, users can safeguard their analytical data, simplify system migration, and avoid common issues.

Clarity File Storage and Organization: A Complete Guide

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