EU Regulation 396/2005: Pesticide Residue Testing and the Critical Role of QuEChERS Evaporation in Food Safety

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 4th May 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you application note by Shimadzu, presentation by MDCW / JEOL and technical note by Thermo Fisher Scientific!<h3>1. MDCW / JEOL: Flow-Modulated GCxGC-QMS Analysis Without Splitting Off the GC Flow</h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_16_Jensen_11e29d5022.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div>This presentation by Kirk Jensen (JEOL USA) explores the feasibility of performing flow-modulated comprehensive two-dimensional gas chromatography (GC×GC) coupled with quadrupole mass spectrometry (QMS) without splitting the GC flow, which is traditionally required to protect MS systems from high carrier gas flows. The core concept builds on GC×GC, where compounds are separated using a primary and secondary column connected via a modulator, significantly increasing separation power compared to one-dimensional GC. The presentation contrasts thermal modulation (offering sharper peaks and higher theoretical sensitivity but requiring cryogenic cooling) with flow modulation, which avoids cryogens, handles volatile analytes well, and is more flexible, but typically demands higher gas flows that standard MS systems cannot tolerate .To address this limitation, the study utilizes the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=24&amp;search=JMS-Q1600GC">JEOL JMS-Q1600GC</a> UltraQuad quadrupole GC-MS system, which can accept unusually high carrier gas flows (up to ~20 mL/min), enabling direct coupling with a SepSolve INSIGHT flow modulator without splitting the effluent . The analytical setup includes dual GC columns (e.g., Zebron ZB-5MSplus for the first dimension and BPX50 for the second), high secondary flow rates (~25 mL/min), and electron ionization (EI) MS detection. Additional system components include optional FID detection, bleed line control, and ChromeSpace software for data processing . This configuration allows full analyte transfer into the MS, eliminating the need for flow splitting and potentially improving detection efficiency.Experimental results demonstrate the applicability of this approach to complex mixtures, including a pesticide mixture containing over 200 compounds and real-world samples such as perfumes and fuels. The GC×GC-MS system produced detailed two-dimensional chromatograms with high spectral quality, enabling the correct identification of approximately 120 compounds despite relatively moderate spectral match factors . Comparisons at different flow rates (e.g., 25 vs. 50 mL/min) showed that spectral integrity and compound identification remain robust, indicating that higher flow operation does not significantly compromise MS performance.In conclusion, the work demonstrates that flow-modulated GC×GC-QMS without flow splitting is feasible, provided that the MS system can tolerate high carrier gas flows. While further optimization is needed (e.g., column selection, inlet pressure, and separation conditions), the approach offers a practical alternative to thermal modulation by eliminating cryogens and simplifying operation. Future work will focus on improving sensitivity, optimizing separations, and exploring alternative carrier gases such as hydrogen to reduce costs and expand applicability</div></div></div></div></div></div></section><h3>2. Shimadzu: Detailed Hydrocarbon Analysis by Nexis GC-2030 Using ASTM D6730</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00863_en_eb633bc741.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>Detailed compositional analysis of gasoline in accordance with ASTM D6730 is feasible using the Nexis GC-2030.&nbsp;</li><li>By employing PONAsolution, a PONA/DHA analysis software, laborious identification tasks can be reduced, and quantitation calculations and report generation can be performed automatically.</li></ul>ASTM D6730 specifies the analysis of hydrocarbons in gasoline and oxygenates such as ethanol, methyl tert-butyl ether (MTBE), and ethyl tert-butyl ether (ETBE) over a boiling point range up to 225 ̊C. Identification and quantification of individual compounds in gasoline are critically important for refinery process control and product quality assurance. In this application news, we report compositional analysis of gasoline conforming to ASTM D6730 using the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexis+GC-2030">Nexis GC-2030 gas chromatograph</a>. Gasoline typically comprises over 100 hydrocarbons, making identification tasks highly complex; however, PONAsolution, a PONA/DHA analysissoftware,simplifies this process.<h4>PONAsolution</h4>PONAsolution Ver.6 provides retention index libraries for each relevant standard (ASTM D6730, D6729, D5134, D6733). Identification of n-alkanes automatically corrects the retention times of the remaining several hundred components, thus streamlining the identification process. When only a specific retention region requires adjustment, the two-point identification function is useful (Fig. 1). In the two-point identification procedure, reference and sample chromatograms are compared while assigning corresponding peaks. First, click on an identified component mark in the reference data (Fig. 1, a), then click the matching sample peak (Fig. 1, b). Repeat this for a second pair of peaks. The retention times of components between these two anchor points are then automatically corrected.<h4>Conclusion</h4>Compositional analysis of gasoline in accordance with ASTM D6730 was performed. The combination of SH PONA Tuning Column and SH-1 PONA main column enabled separation of compounds with closely spaced retention times. Moreover, use of PONAsolution software greatly simplifies complex identification tasks.<h3>3. Thermo Fisher Scientific: Fiber optic probes add flexibility to Raman chemical analysis</h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/drx3_flex_tech_note_tn54708_bebb56b870.pdf">Full PDF for download</a></li></ul>Fourier Transform Infrared Spectroscopy (FTIR) and Raman Spectroscopy are non-destructive analytical techniques that rely on the interaction of electromagnetic radiation with molecular vibrations to provide information about the chemical composition and structure of a sample. Despite their similarities, there are some distinct differences between the two techniques. In principle, FTIR is based on the absorption of infrared radiation by molecules and measures changes in dipole moment during molecular vibrations. Raman spectroscopy, on the other hand, is based on the inelastic scattering of monochromatic light and measures changes in polarizability during molecular vibrations.&nbsp;When applied to bulk chemical analysis, both FTIR and Raman spectroscopy can be used to analyze solids, liquids, and gases, but the nature of Raman spectroscopy lends some unique sampling advantages. Additionally, Raman often requires little to no sample preparation. Presented herein are application examples that highlight some of the sampling advantages of Raman spectroscopy. All the spectral data in this technical note were collected using a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2238">Thermo Scientific™ DXR3 Flex Raman Spectrometer</a> equipped with a fiber optic probe. (Fiber optics are readily available for Raman spectroscopy because of the use of visible and NIR light and do not require the exotic materials associated with FTIR fiber optics.) Preliminary tests for all samples were carried out using both 532 nm and 785 nm excitations, and it was determined that the 785 nm laser set gave an overall better balance between fluorescence and Raman scattering efficiency.<h4>Summary&nbsp;</h4>In this technical note, the analyses of a variety of samples by Raman spectroscopy are demonstrated. All samples were analyzed without sample preparation.&nbsp;<ul><li>Precise and localized analysis at the focal point of the Raman-exciting laser allows sampling through glass bottles, blister packaging and plastic containers, which eliminates possible cross contamination and analyst exposure to hazardous materials. The contributions from the packaging and containers depend on the type of container material, the container thickness, and the materials’ chemical compositional complexity, but these contributions can be readily subtracted out when needed.&nbsp;</li><li>Water is a weak Raman scatterer. Raman therefore has reduced water sensitivity, making it a preferred technique for aqueous solution analysis over FTIR. As demonstrated in the analysis of an energy drink, the Raman bands from water can be subtracted from the spectrum of the aqueous solution, leading to the identification of the components of the solution.&nbsp;</li><li>Raman spectroscopy is well suited for the analysis of inorganic materials, especially in identifying the crystal phases and polymorphs, as demonstrated by the analyses of minerals and pigments in a painting.&nbsp;</li><li>Fiber optic probes provide flexibility and ease of maneuverability. This is particularly advantageous when analyzing samples that are difficult to access or manipulate, such as large containers, geological samples and paintings</li></ul>The DXR3 Flex has multiple sampling options available. A properly configured fiber-optic probe is arguably the most versatile accessory for the analysis of bulk solids and liquids. The advantages, both from those inherent to Raman spectroscopy and those resulting from the use of fiber optic probe, provide opportunities for a wide variety of different applications when using the DXR3 Flex Raman Spectrometer.

News from LabRulezGCMS Library - Week 19, 2026

🎤Francis Femi OloyIn this episode of Concentrating on Chromatography, David speaks with Francis Femi Oloy about using chromatography to uncover hidden pollutants in real-world water systems.Femi’s team analyzed polychlorinated biphenyls (PCBs) in six major rivers in southwestern Nigeria — compounds that were banned decades ago but still persist in the environment. Using a workflow that many analytical labs will recognize — liquid–liquid extraction, cleanup, rotary evaporation, nitrogen blowdown, and GC-ECD detection — they quantified 25 PCB congeners at trace levels and linked the results to ecological and human health risk.<h4>In this conversation, we cover:</h4><ul><li>Why legacy pollutants like PCBs still show up today</li><li>Choosing GC-ECD vs LC-MS for halogenated compounds</li><li>Liquid–liquid extraction and matrix cleanup strategies</li><li>Why sample concentration is critical for dilute environmental samples</li><li>How rotovap + nitrogen blowdown work together without losing volatile analytes</li><li>Seasonal trends (why wet season levels were higher)</li><li>Translating concentration data into meaningful risk assessments</li></ul><h3>Video Transcription</h3><section><div><div><div><div><div><div>Persistent organic pollutants such as polychlorinated biphenyls (PCBs) remain a significant environmental concern despite decades of regulatory restrictions. In this interview, Francais Femi Oloy discusses the environmental and analytical challenges associated with monitoring PCB contamination in rivers of southwestern Nigeria, a rapidly industrializing region where urban growth, industrial activity, agriculture, and dense populations intersect with extensive aquatic systems.Oloy explains that his interest in environmental contaminant analysis emerged from observing unexplained health problems and environmental degradation while growing up in Nigeria. This motivated his transition into organic and environmental chemistry, with a focus on identifying pollutants present in drinking water, agricultural soils, and food systems. Southwestern Nigeria, particularly the Lagos region, represents a critical environmental monitoring area due to intense industrial development, shipping activity, and widespread human dependence on rivers for domestic use, agriculture, and fishing.Although PCBs are considered “legacy pollutants” and are no longer intentionally produced, the interview highlights why they continue to persist in aquatic environments. Old electrical transformers and aging industrial equipment still contain PCB residues, while historical contamination stored in river sediments can become remobilized during flooding, dredging, or sediment disturbance. Because PCBs are hydrophobic and resistant to degradation, they preferentially accumulate in sediments and bioaccumulate through aquatic food chains, creating long-term environmental and human exposure risks.A major focus of the discussion centers on the analytical workflow used for PCB determination in environmental water samples. Composite river water samples were collected in amber glass bottles to avoid contamination and photodegradation, preserved with sodium azide to minimize microbial activity, and stored under cooled conditions prior to extraction. The analytical protocol employed liquid–liquid extraction using dichloromethane (DCM) and hexane to recover both polar and nonpolar PCB congeners. Oloy emphasizes that liquid–liquid extraction was selected over solid-phase extraction (SPE) because of concerns about congener retention within sorbent materials and clogging issues associated with large-volume environmental samples.Following extraction, concentration and cleanup represented critical analytical stages due to the trace-level occurrence and volatility of PCBs. Silica and alumina cleanup procedures were used to remove matrix interferences prior to instrumental analysis. The concentration workflow combined rotary evaporation for bulk solvent reduction with nitrogen blowdown for final volume reduction to less than 1 mL, while carefully avoiding excessive temperature or complete dryness to minimize analyte loss. Oloy repeatedly stresses that improper concentration procedures are among the most common causes of analytical failure in PCB analysis.For instrumental determination, the study utilized gas chromatography coupled with electron capture detection (GC-ECD) rather than LC-MS or GC-MS. According to Oloy, GC was preferred because PCBs are sufficiently volatile for gas chromatographic separation, while ECD provided superior sensitivity and selectivity for chlorinated compounds at environmentally relevant concentrations. The interview also discusses analytical validation strategies, including the use of surrogate standards to assess recoveries, which ranged from approximately 85% to 114%, and signal-to-noise-based determination of detection limits.The study further examined seasonal variations in PCB concentrations, revealing higher levels during the wet season. This observation was attributed to rainfall-driven runoff from contaminated infrastructure, sediment resuspension, and lower temperatures that reduce volatilization losses. To communicate toxicological relevance beyond simple concentration reporting, the researchers also calculated toxic equivalency values (TEQs), converting mixtures of PCB congeners into biologically meaningful toxicity estimates comparable to dioxin toxicity metrics.Beyond environmental monitoring, Oloy highlights broader research interests focused on pollutant remediation and sustainable environmental protection. His group is also involved in developing catalytic materials capable of degrading or removing persistent contaminants from environmental systems. Throughout the discussion, he emphasizes that analytical chemistry plays a central role not only in detecting pollutants, but also in enabling prevention, remediation, and long-term environmental management strategies.</div></div></div></div></div></div></section><blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

Tracking Toxic PCBs in River Water using Gas Chromatography–Electron Capture Detection

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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Thermo Fisher Scientific

SelectScience

Non-alcoholic (NA) and low alcoholic beers (LABs) are growing in demand worldwide. However, dealcoholization or arrested fermentation leads to changes in the overall aroma and flavor profiles compared to full strength (FS) beer analogues.
This webinar Dr. Tiffany Crawford, Kalsec Inc., Megan Harper, GERSTEL, Inc., and Matt Curtis, Agilent will discuss a semi-targeted method developed using DHS-GC-MS technology that allows for the improvement of NA beer flavor through the addition of specialized hops products. They will also examine the use of GC-MS-O technology to determine the source of off-odors in a plant extract matrix. A brief overview of the GERSTEL dynamic headspace (DHS), Thermal Desorption Unit (TDU), and olfactory detection port (ODP) systems will be highlighted in order to understand their contributions to this work. The Agilent 7250 GC/QToF functionality will also be reviewed, along with the software tools e.g. SureMass feature-finding and MassProfiler Professional.
Key learning objectives
<ul>
<li>Understand the analytical challenges in the determination of off-flavors and off-odors in complex matrices
</li>
<li>Discover how a combination of GERSTEL and Agilent instrumentation and software can improve analysis for food and beverage applications
</li>
<li>Explore how analytical techniques can be used to identify and solve sensory issues in food products
</li>
</ul>
Who should attend?
<ul>
<li>Chemists and lab managers from contract testing labs and the food and beverage industry</li>
</ul>
<blockquote>
Presenter: Dr. Tiffany Crawford (Lead Scientist 1: Hops, Kalsec Inc.)
</blockquote>
<blockquote>
Dr. Tiffany Crawford works for Kalsec Inc. as a lead scientist in the hops business unit. In her role, she develops methods using GC-MS and LC-MS technology for the detection of small molecules of interest in different food matrices. She holds a Ph.D in Chemistry from the University of North Carolina at Chapel Hill.
</blockquote>
<blockquote>
Presenter: Megan Harper (Applications Scientist I, GERSTEL, Inc.)
</blockquote>
<blockquote>
Megan Harper works for GERSTEL, Inc. as an Applications Scientist. In her role, she applies her knowledge of GC-MS and sample extraction and introduction techniques to help solve complex problems for customers across the USA.
</blockquote>
<blockquote>
Presenter: Matt Curtis (GCMS Application Scientist, Agilent)
</blockquote>
<blockquote>
Matt Curtis joined Agilent in 2013 as a GC/MS applications scientist in the Santa Clara, CA Center of Excellence. His primary responsibility is providing instrument demonstrations for customer interested in each technology Agilent offers: the GC/MS single quadrupole, triple quadrupole and the quadrupole Time-of-Flight. The variety of different samples submitted to the demo lab provides a unique knowledge of optimizing parameters for different applications to provide the best quality data from the instrument.
</blockquote>
<blockquote>
Presenter: Ellen Simms (Editorial Team, SelectScience)
</blockquote>
<blockquote>
Ellen studied biological sciences at the University of the West of England, UK, before completing a master&#39;s in epidemiology from the University of Bristol. As a member of the Editorial team, she now plays an integral role in shaping the content on SelectScience.
</blockquote>

SelectScience: GC-MS solutions for sensory analysis in non-alcoholic beers

GC-MS solutions for sensory analysis in non-alcoholic beers

Semi-targeted method developed using DHS-GC-MS technology that allows for the improvement of NA beer flavor through the addition of specialized hops products.

Sample preparation is one of the most important steps of the analytical process and has the largest impact on the quality and the reliability of the analytical data package. The three major reasons for performing sample preparation are the following.
<ul>
<li>Reduce or eliminate sample incompatibility with the analytical systems (analysis of solid samples with gas or liquid chromatography-based technique)</li>
<li>Eliminate heavy matrix components and reduce matrix interferences</li>
<li>Concentrate the samples</li>
</ul>
A “good” sample preparation method would meet the following requirements:
<ul>
<li>Non discriminative for the targets and discriminative for the matrix interferences</li>
<li>Result of the extraction is predictable</li>
<li>Quick</li>
<li>Cost effective</li>
<li>Automated</li>
<li>Complies with current regulations and regulatory expectations</li>
<li>Highly repeatable</li>
<li>Easy to perform</li>
<li>Safe for the environment</li>
</ul>
Depending of the target analyte group, different sample preparation techniques should be used in the analytical process. Mass spectrometry, hyphenated with chromatographic separation, has a long and successful history of analyzing finished product of different natures (pharmaceuticals, medical devices, and consumer products). Its versatility, unmatched low detection limit, and capability to detect a wide range of organic compounds makes it ideal to characterize those various finished products. Mass spectrometry can be used for high-sensitivity targeted analysis, as well as non-targeted screening, and it is also an excellent research tool for identifying previously unknown chemical entities.
Recently, the relatively easy access to tandem (MS/MS) and high-resolution accurate mass based systems (HRAM), can lower the detection limit of high-risk targeted analytes. To enhance the productivity of the mass spectrometric detection, it is very often combined with an automated sample preparation option such as static head-space or SPME. This presentation will focus on presenting case studies for using various high-performance sample preparation methods in combination with either HRAM or MS/MS detection.
<blockquote>
Presenter: Gyorgy Vas, Ph.D. (Owner, VasAnalytical)
</blockquote>
<blockquote>
“Research is four things: brains with which to think, eyes with which to see, machines with which to measure, and fourth, money.” - Prof. Albert Szent-Gyorgyi
</blockquote>
<blockquote>
Gyorgy Vas has over 20 years of experience in scientific research, product development, and laboratory management. More than half of this time was spent in a cGMP environment, where that scientific expertise was applied to solve problems related to finished pharmaceutical products and medical devices. In his current position, he is advising regulatory filing strategy for multiple clients, and his group provides solutions to mitigate deficiency letters. He made significant achievements to implement state-of-the-art solventless sample preparation techniques into the cGMP laboratory processes. Gyorgy is one of the few persons in the field with expertise in method development and validation for ultratrace (parts-per-trillion) level impurities in finished pharmaceutical products and medical devices.
</blockquote>
<blockquote>
Recently he is focusing on applications of HRAM technology hyphenated with gas chromatography to evaluate trace-level impurities in food and pharmaceutical products.
</blockquote>

Thermo Fisher Scientific: Advanced Sample Preparation Combined with Mass Spectrometric Detection (HRAM, TQ) for Analyzing Pharmaceutical, Consumer Products and Medical Devices

Advanced Sample Preparation Combined with Mass Spectrometric Detection (HRAM, TQ) for Analyzing Pharmaceutical, Consumer Products and Medical Devices

Pharmaceutical products come into contact with a wide range of polymeric materials on their journey from the production line to patients, with possible leaching of potentially dangerous substances into products, possibly compromising the stability, or even worse, the pharmacological activity. Extractable and leachable (E&amp;L) compounds are the focus of rigorous testing workflows to ensure therapeutics are safe and meet regulatory requirements.This webcast will present an E&amp;L study aiming to address the challenges to achieve sufficient sensitivity and selectivity for unknown analytes potentially present in the sample.A method has been optimized with the use of static headspace autosampling coupled with a HRAM GC–MS, resulting in a powerful technique to assess and quantify potentially dangerous untargeted volatile extractables down to trace level. Very high mass accuracy with errors of 1 ppm or better, even for smaller molecules and fragments, increases confidence in structure elucidation of unknown compounds.Key Learning Objectives:<ul><li>Learn about streamlining workflow for organic volatile impurities from contact materials</li><li>Learn how to optimize headspace sampling parameters with a strategy based on the theory of gas phase chemistry</li><li>Discover the benefits of using HRAM GC–MS for untargeted or unknown impurities</li></ul>Who should attend:<ul><li>Scientists, chemists, and analysts involved in E&amp;L testing</li><li>Laboratory managers in the pharmaceutical industry, CMOs, CROs and contract services</li><li>Researchers and method developers interested in E&amp;L methodology</li></ul><blockquote>Presenter: Xiaotend (Shelton) Gong (Instrumentation Chemist, Extractable and Leachable (E&amp;L) Testing, SGS)Xiaoteng Gong received his Master’s degree from the Illinois Institute of Technology, and has worked on food contact materials at the National Center for Food Safety and Technology (NCFST) of the Food and Drug Administration (FDA). With extensive experience in analytical chemistry, he currently is an instrumentation chemist at SGS specializing in extractables and leachables (E&amp;L) studies for pharmaceutical packaging. He has more than five years of experience using headspace gas chromatography–mass spectrometry (GC–MS).Presenter:&nbsp;Daniela Cavagnino (Marketing Manager, GC-MS, Thermo Fisher Scientific)Daniela Cavagnino received a Master’s degree in Chemistry from the University of Milan, Italy. She started her career in gas chromatography at Thermo Fisher Scientific, spending several years in the R&amp;D laboratories working on GC technology innovation. Then, she conveyed her technical background into product management and marketing management roles, and she now has more than 15 years of experience promoting GC and GC–MS technology and applications in several different market segments. During her career, she has participated as an author and co-author in technical publications and as a lecturer at international conferences.</blockquote>

Thermo Fisher Scientific: Increased Confidence in Untargeted Volatile E&L Analysis by Static Headspace Sampling Coupled to HRAM GC-MS

Increased Confidence in Untargeted Volatile E&L Analysis by Static Headspace Sampling Coupled to HRAM GC-MS

This webcast presents an E&L study aiming to address the challenges to achieve sufficient sensitivity and selectivity for unknown analytes 

Untargeted Volatile E&L Analysis via Headspace GC-MS

The aromatic profile of Trigonella caerulea (blue fenugreek) develops predominantly after harvest, yet its detailed chemical characterization has long been limited by analytical challenges associated with highly volatile and low-abundance compounds. In this study, conventional GC–MS headspace analysis was complemented by high-resolution GC–MS employing cyanopropyl-functionalized stationary phases to improve compound separation and identification.While standard GC–MS enabled the detection of major volatile aldehydes and monoterpenoids, high-resolution GC–MS proved essential for resolving co-eluting compounds and identifying very volatile aroma constituents with greater confidence. In parallel, non-volatile α-keto acids were quantified by LC–MS to provide a comprehensive view of aroma precursors.Comparative analysis demonstrates that high-resolution GC–MS significantly enhances analytical depth and accuracy, allowing a more complete understanding of aroma formation dynamics during drying and storage. These results underline the critical role of advanced chromatographic techniques in elucidating complex herbal aroma systems.<h4>Learning points:</h4><ul><li>Analytical resolution matters: High-resolution GC–MS provides superior chromatographic separation and compound identification compared to conventional GC–MS, enabling reliable detection of highly volatile and low-abundance aroma compounds that would otherwise remain unresolved.</li><li>Method choice shapes interpretation: The apparent aromatic profile of Trigonella caerulea depends strongly on the analytical technology used, with advanced GC–MS approaches revealing a substantially higher chemical complexity than standard methods.</li><li>Integrated analytics are essential: Combining high-resolution GC–MS for volatile compounds with LC–MS for non-volatile aroma precursors allows a more complete understanding of aroma formation dynamics during drying and storage.</li></ul><h4>Who should attend?</h4><ul><li>Analytical chemists and method developers&nbsp;</li><li>Food, flavor, and fragrance scientists&nbsp;</li><li>Natural products and phytochemistry researchers&nbsp;</li></ul>If you cannot attend this webinar please register to receive a link to the On Demand version the following day.<blockquote>Presenter: Dr. Thomas Stegemann (Lab Manager and group leader, Christian-Alberts-University Kiel)Thomas has a Dr. in pharmacy, deep GC and GC/MS knowledge and combines both assets working for the University in cooperation with Pharma companiesPresenter:&nbsp;Petra Gerhards (Regional Marketing Manager, EMEA, AAT, Thermo Fisher Scientific)</blockquote>

Thermo Fisher Scientific: Aromatic profiling using GCMS and HRGCMS

Aromatic profiling using GCMS and HRGCMS

Learn how HRMS GC–MS and LC–MS improve characterization of blue fenugreek aroma compounds and reveal complex flavor formation during drying and storage.

GCMS webinars focusing on GC/HRMS, GC/MS/MS, HeadSpace - page 1