Clarity 10.2 expands instrument control capabilities with new control modules and updates the MS extension to help you work more efficiently.<h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity</a> 10.2 highlights</h4><ul><li>New and updated control modules</li><li>Improved MS data import and export</li><li>Obsolete hardware support ended</li></ul><h4>Instrument control modules</h4>Clarity 10.2 introduces new instrument control modules from Annuo (AS-3117, FAS-3823) and updated instrument controls form Sykam and Ecom.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Instrument_control_modules_5de26782b0.jpg" alt="DataApex: Instrument control modules" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Instrument_control_modules_5de26782b0.jpg 228w," sizes="100vw" width="380" height="260"><h4>MS data import/export improvements</h4>Clarity improves MS data exchange, especially for *.cdf files. MS instruments now support export and import of multiple spectral data and non-spectral signal data in the same CDF file. Import also better handles uniform sampling information, m/z Step values, scale factors, and file names with non-ASCII characters. Exporting individual chromatogram signals from MS instruments is now available through a separate Export Chromatogram dialog.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg" alt="DataApex: MS data import-export improvements" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg 228w," sizes="100vw" width="378" height="259"><h4>Obsolete hardware support terminated</h4>Due to changes in Windows driver security requirements, this update discontinues support for obsolete hardware, including INT7, INT9, U-PAD, U-PAD2, and CB20.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg" alt="DataApex: Obsolete hardware support terminated" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg 228w," sizes="100vw" width="378" height="259"><blockquote>Explore the complete list of all changes, fixes, and additions in version 10.2.👉<a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1">See the complete changelog&nbsp;</a></blockquote>

Clarity Chromatography Software 10.2 released!

Traditional EI library searching works exceptionally well when the unknown compound is already present in the spectral library. However, analytical chemists frequently encounter compounds that are structurally related to library entries but are not exact matches. NIST's EI Hybrid Search addresses this challenge by combining conventional spectral matching with mass-shifted fragment alignment, allowing the identification of analogs, derivatives, and novel compounds that may not exist in the database.This guide summarizes the workflow presented by James Little and demonstrates how to use NIST 26 Hybrid Search in conjunction with the Chromatogram Window and MS Interpreter to obtain more meaningful structural information from unknown EI GC-MS spectra.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/paper/33370">You can download PDF Handout for this guide HERE</a></blockquote><h4>Why Hybrid Search Matters</h4>Conventional EI library searching relies on direct matching between an unknown spectrum and spectra stored in a library. Hybrid Search expands this concept by allowing fragment ions to be matched even when they are shifted by a consistent mass difference (Δm). This enables the software to recognize compounds that differ by substituents or structural modifications.Key advantages include:<ul><li>Identification of structurally related compounds not present in the library</li><li>Detection of analogs, derivatives, and emerging compounds</li><li>Integration of exact fragment matches and mass-shifted matches into a single score</li><li>Improved interpretation of unknowns through proposed structural modifications</li><li>Enhanced confidence when molecular weight information is available</li></ul>Although Hybrid Search does not require the molecular ion to be present, performance improves significantly when the molecular weight can be estimated or constrained. In these cases, the observed mass difference between the unknown and library compounds can often be translated directly into a plausible chemical modification.<h4>Configuring Hybrid Search</h4>Before performing a search, the Hybrid Search settings should be configured within the NIST Library Search window.Recommended settings:<ul><li>Select the Similarity search mode</li><li>Enable Hybrid Search</li><li>Keep the In Spectrum option checked under normal circumstances</li><li>Allow the software to estimate the molecular weight automatically</li><li>If the estimated molecular weight appears incorrect, manually enter a nominal molecular weight</li><li>Select all relevant libraries (NIST, Wiley, user libraries, etc.)</li><li>Save the configuration for future use</li></ul>The selected molecular weight used to constrain the search is displayed in the lower-right corner after the search is completed.<h4>Optimizing the Results Display</h4>Hybrid Search produces several unique parameters that are not shown in the default results table.Additional columns should be added by right-clicking within the results table and selecting Properties. Recommended columns include:<ul><li>DeltaMass</li><li>dForm</li><li>pctRelForm</li><li>o.Match (equivalent to the traditional EI Normal Match score)</li></ul>Without these parameters, much of the structural interpretation power of Hybrid Search is lost.<h4>Working with Spectra from the Chromatogram Window</h4>Currently, the Chromatogram Window performs standard EI library searching. When a potentially interesting unknown is encountered:<ul><li>Perform the normal EI search in the Chromatogram Window</li><li>Send the spectrum to the standalone Library Search module</li><li>Perform a Hybrid Search using the enhanced Hybrid Search functionality</li></ul>This workflow combines rapid screening with advanced structural interpretation.<h4>Understanding Key Hybrid Search Parameters</h4><h5>DeltaMass (Δm)</h5>DeltaMass represents the mass difference between the unknown compound and the matched library compound.A consistent Δm across multiple high-scoring hits often indicates a specific structural modification.<h5>dForm</h5>dForm provides a proposed elemental composition that explains the observed mass difference.Examples include:<ul><li>H–1F</li><li>CH₂</li><li>O–1</li><li>C₁H₃F</li></ul>These transformations can suggest likely chemical modifications between the library compound and the unknown.<h5>pctRelForm</h5>New in NIST 26, pctRelForm estimates how frequently a given elemental transformation occurs relative to the most common transformation (CH₂ = 100%).Interpretation:<ul><li>High values indicate chemically plausible and commonly observed transformations</li><li>Very low values suggest the proposed transformation may be accidental or unlikely</li></ul><h5>o.Match</h5>Represents the traditional EI match score and allows comparison between standard searching and Hybrid Search results.<h4>Case Study: Identifying a Fluorinated Unknown</h4>The presentation demonstrates the identification of an unknown compound with a proposed molecular weight of 152 Da.Hybrid Search returned several high-scoring hits with consistent evidence suggesting fluorine substitution:Hit #1<ul><li>Library MW: 134</li><li>DeltaMass: +18</li><li>dForm: H–1F</li><li>Interpretation: Addition of fluorine</li></ul>Hit #5<ul><li>Library MW: 138</li><li>DeltaMass: +14</li><li>dForm: CH₂</li><li>Interpretation: Related fluorinated analog</li></ul>Hit #6<ul><li>Library MW: 168</li><li>DeltaMass: –16</li><li>dForm: O–1</li><li>Interpretation: Structurally consistent fluorinated compound</li></ul>Multiple independent hits converged on the same conclusion: the unknown was likely a fluorinated analog of known aromatic compounds.This illustrates the major strength of Hybrid Search: identifying structural relationships even when the exact compound is absent from the library.<h4>Moving from Hybrid Search to Structural Interpretation</h4>Once a plausible structure is identified:<h5>Step 1 – Export the Structure</h5>From the Hybrid Search results:<ul><li>Right-click the best hit</li><li>Use Send To → Default Structure Editor</li><li>Open the structure in a drawing program such as ChemSketch</li><li>Copy the proposed structure to the clipboard</li></ul><h5>Step 2 – Open MS Interpreter</h5>Within MS Interpreter:<ul><li>Paste the proposed structure</li><li>Load the unknown spectrum</li><li>Compare predicted fragmentation with observed ions</li><li>Evaluate isotope patterns and fragment assignments</li></ul><h5>Step 3 – Validate the Proposal</h5>Indicators of a good structural proposal include:<ul><li>Consistent isotope ratios</li><li>Logical fragmentation pathways</li><li>Agreement between observed and predicted fragment ions</li><li>Multiple Hybrid Search hits supporting the same structural modification</li></ul>In the example presented, MS Interpreter showed excellent agreement between the proposed fluorinated structure and the observed EI spectrum, although the exact positions of the fluorine and methyl substituents on the aromatic ring could not be definitively assigned.<h4>Best Practices</h4><ul><li>Always review DeltaMass, dForm, and pctRelForm together</li><li>Do not rely solely on the highest match score</li><li>Give greater weight to transformations supported by multiple independent hits</li><li>Use molecular weight information whenever possible</li><li>Confirm structural hypotheses using MS Interpreter</li><li>Consider Hybrid Search as a structure-elucidation tool rather than simply a library search tool</li></ul><h4>Conclusion</h4>NIST 26 Hybrid Search significantly extends the capabilities of conventional EI library searching by identifying structural relationships between unknown compounds and library entries. Through the use of DeltaMass calculations, elemental transformation analysis (dForm), and statistical plausibility metrics (pctRelForm), Hybrid Search provides valuable clues for elucidating compounds that are absent from spectral libraries.When combined with MS Interpreter, it becomes a powerful workflow for the characterization of unknowns, analogs, degradation products, metabolites, and emerging compounds in EI GC-MS analysis.

Lib Search: Similarity EI Hybrid Search for Spectra Sent from Chromatogram Window

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 22nd June 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you brochure by Agilent Technologies, application note by Shimadzu and posters by MDCW / William &amp; Mary and Waters Corporation / ASMS!<h3>1. Agilent Technologies: Operational efficiency for your GC and GC/MS labs with the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B">Agilent 8890B gas chromatography system</a></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/br_8890b_gc_5994_9205en_agilent_fb5db29527.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div><h4>Analyze more samples every day with faster cycle times&nbsp;</h4>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B">8890B GC </a>provides faster maximum oven temperature ramps and cooldown rates for conventional dual-channel GC. If you want even faster cycle times, an optional rapid cooling fan is available.&nbsp;<h4>Achieve excellent repeatability across multiple injections&nbsp;</h4>Consistent retention time and area count performance are the cornerstone of what you can expect from the 8890B GC. The system also meets all specifications required for regulatory methods such as USP Method &lt;467&gt; (residual solvents).<h4>Shine a new light on your connections and components&nbsp;</h4>Make maintenance easier and faster with a built-in oven light that illuminates the internal space on the 8890B GC. That means you can perform tasks like troubleshooting and column installation in less time—and with fewer errors.<h4>Boost GC performance with capillary flow technology&nbsp;</h4><ul><li>Backflush significantly reduces timing between injections, increasing productivity.&nbsp;</li><li>Purged Ultimate unions provide leak-free connections, reducing downtime.&nbsp;</li><li>Flow splitters enable data collection from up to three detectors.&nbsp;</li><li>New CFT calculators let you download calculated setpoints to your method—avoiding time-consuming, error-prone manual input.&nbsp;</li><li>Multidimensional chromatography:&nbsp;<ul><li>Deans Switch facilitates heart cutting, enabling resolution of trace compound in complex matrices.&nbsp;</li><li>GC x GC flow modulation enables multidimensional chromatography without the need for cryogen</li></ul></li></ul><h4>Helium conservation module&nbsp;</h4>Extend the life of your helium tanks by up to 30 times. The Agilent helium conservation module allows you to use helium for your GC runs and switch to a different gas (typically nitrogen) when your GC is idle. That means you can achieve better control of laboratory operating expenses and avoid workflow disruptions.<h4>Alternative carrier gas support&nbsp;</h4>Alternative carrier gases like hydrogen and nitrogen are popular low-cost options.&nbsp;The Agilent Hydrogen Sensor Module Series 2 option adds built-in peace of mind when operating with H2 gas.&nbsp;The Agilent HydroInert source minimizes sensitivity loss and spectral anomalies associated with H2. It also:&nbsp;<ul><li>Maintains spectral fidelity, even for compounds highly susceptible to hydrogenation.&nbsp;</li><li>Improves peak shape for high-boilers, especially polycyclic aromatic hydrocarbons (PAHs)</li></ul><h3>2. MDCW / William &amp; Mary: Decomposition Analysis Using Differing Data Processing Methods to Identify Volatile Organic Compounds</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/P_25_Weina_2ae94f0998.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div>When a body decomposes it emits volatile organic compounds (VOCs). VOCs from decomposing remains have been studied before,1 however there is a gap that remains in the knowledge on VOCs that evolve from submerged decomposing remains. 2 In this study, submerged animal tissue was tested to see how the VOCs can be utilized in forensic settings.&nbsp;This study used data obtained last summer using comprehensive two-dimensional gas chromatography – time-of-flight mass spectrometry (GC×GC-TOFMS). Pigs (Sus scrofa domesticus) are often used as analogs in decomposition studies due to similarities with humans. 3 In this study, pork belly samples were submerged in mason jars filled with water and stored at different temperatures. The GC×GC-TOFMS instrument was used to collect odor from above water samples for a period of twelve days.GC×GC is often used to analyze complex odor profiles. When analyzing samples with GC×GC, there is a lack of standardization to process the data acquired from time trials. There is a need to discover effective ways to track VOCs for chemical identification and longitudinal analysis.The goal of this research was to compare different software approaches to analyze GC×GC longitudinal data to achieve accurate analyte identification, representation of data over time, and effective class characterization.<h4>Methods</h4>For the first four days, 5 mL of water was taken and run on the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37">GC×GC-TOFMS</a>. Thereafter, the samples were sampled and run every three days until day twelve. Data were analyzed initially using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/41">ChromaTOF</a> (LECO Corporation). The samples were then analyzed using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/348">ChromaTOF Tile </a>and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1873">ChromaTOF Sync 2D</a> to compare how they can be used in a forensic setting.Peak tables were curated in Tile and Sync 2D. Then, ChromaTOF was used as a guide to confirm which peaks were identified correctly. If the compound was correctly identified, the peak would be accepted or kept on the table. If not correctly identified, the peak would either be rejected or deleted. Once the tables were complete from the different software approaches, they were exported to Excel for further comparison.In excel, the relevant hits that were identified as decomposition VOCs were compared across the software approaches. The compounds that were most commonly found were compared to existing literature on decomposition VOCs. From there, two tables were built; where one table was compounds confirmed with literature and the other table was compounds not confirmed with literature.Comparison between software approaches included looking at different criteria to see which method was the most effective and efficient. The criteria included how long the software approach took, the number of compounds found in each software approach, the accuracy of peak area in the software approach compared to ChromaTOF data, and principal component analysis (PCA) comparison to see which software approach was best used for forensic practice or research.<h4>Conclusions</h4>Sync 2D showed the capability of showing trends in decomposition compounds<ul><li>This software approach can be used in research environment where longitudinal data is needed to determine the trends of decomposition data&nbsp;</li><li>Best purpose: research applications requiring longitudinal tracking&nbsp;</li></ul>Coefficient of Variance’s and Fold Change’s PCA plots showed their ability for clear class differentiation&nbsp;<ul><li>The two software approaches can be used to distinguish water containing decomposition in a crime scene&nbsp;</li><li>Best purpose: comparison at a single point and time [detailed analysis]&nbsp;</li></ul>Fisher Ratio showed a proficiency in identifying top differentiating compounds and showed aptitude for class differentiation&nbsp;<ul><li>The software approach would be helpful for cursory analysis for crime scene evidence&nbsp;</li><li>Best purpose: quick comparison of biggest difference for swift identification</li></ul><h3>3. Shimadzu: Determination of Ester and Linolenic Acid Methyl Ester Contents in Biodiesel According to EN 14103:2020</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_05_sca_180_054_en_93d1029b72.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=2060">NexisTM GC-2060</a> provides reliable analysis of biodiesel samples regarding their ester and linolenic acid methyl ester contents using hydrogen as a cost-effective carrier gas&nbsp;</li><li>It delivers excellent repeatability and provides appropriate safety measures for the use of hydrogen as carrier gas&nbsp;</li><li>The optional multi-mode injection unit (MMI) offers performance equivalent to a conventional split-splitlessinjection unit (SPL), significantly reducing maintenance downtime</li></ul>Biofuels play an important role in enabling countriesto meet their greenhouse gas reduction targets. They can be produced from a range of raw materials, including plant oils, animal fats, and used cooking oils. Biodiesel is mainly being produced from rapeseed, soybean, and palm oils. Due to this diversity of feedstocks, continuous quality control is necessary as the quality of the raw material has an enormousimpact on the quality of the biodiesel.&nbsp;The EN 14103:2020 describes the determination of total ester content and linolenic acid methyl ester content in biodiesel by means of gas chromatography with flame ionization detection (GC-FID). The total ester content covers a range of fatty acid methyl esters (FAME) from C6 to C24, and linolenic acid methyl ester is investigated separately as interfering reactive compound that might influence long-term stability of the biodiesel. According to the standard, the total ester content must be greater than 90 % (m/m) and the linolenic acid methyl ester content shall be between 1 and 15 % (m/m)1.This study shows the analysis of biodiesel originating from rapeseed,soybean, and palm oil using the Nexis GC-2060.<h4>Multi-Mode Injection Unit as Alternative&nbsp;</h4>Shimadzu’s multi-mode injection unit (MMI) offers reliable splitsplitless mode functionality over a broad range of carbon numbers. It allows analysis of biodiesel samples with high repeatability and provides chromatographic results comparable to those measured with SPL as dedicated split-splitless injection unit. The use of MMI significantly shortens maintenance downtime from tens of minutes for a classical split-splitless injection unit to just a few minutes. Figure 3 gives a direct comparison of an exemplary rapeseed-based biodiesel sample measured with SPL (top) and MMI (bottom).<h4>Conclusion</h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=2060">Nexis GC-2060</a> provides reliable analysis of biodiesel samples regarding their ester and linolenic acid methyl ester content according to EN 14103:2020, covering the various ester types commonly in use. It allows repeatable analysis using hydrogen as a cost-effective carrier gas. The optional multi-mode injection unit (MMI) can be selected as alternative to a classical splitsplitlessinjection unit (SPL).<h3>4. Waters Corporation / ASMS: Putting the (Atmospheric) Pressure on Forever Chemicals: A Targeted Analysis of GC Amenable PFAS using APGC–MS/MS</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009413_dfa4082b45.pdf">Full PDF for download</a></li></ul>This poster presents a targeted analytical method for the determination of gas chromatography (GC)-amenable PFAS compounds using atmospheric pressure gas chromatography coupled with tandem mass spectrometry (APGC-MS/MS). The study addresses a key limitation of conventional LC-MS/MS methods, which are highly effective for many PFAS but less suitable for more volatile species such as fluorotelomer alcohols (FTOHs), fluorotelomer acrylates (FTAcr), and fluorotelomer acetates (FTOAc). By incorporating GC-MS/MS analysis, laboratories can obtain a more complete characterization of PFAS contamination across environmental, biological, and food-contact materials.The analytical workflow utilized an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890">Agilent 8890 gas chromatograph</a> equipped with an autosampler and coupled to a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/554">Waters Xevo TQ Absolute tandem mass spectrometer</a> operated with APGC ionization in positive-ion mode. Separation was performed on an Rtx-200 capillary column, while data acquisition and quantification were managed using <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544">waters_connect software</a>. Unlike traditional electron ionization (EI), APGC generated intact protonated molecular ions, significantly improving sensitivity and selectivity for GC-amenable PFAS. A method covering 35 PFAS compounds was developed, achieving lower limits of quantification (LLOQs) of 0.025–0.1 ng/mL for most analytes.Several sample types were evaluated, including wastewater, surface water, soil, fish tissue, shrimp, and food-packaging materials. Environmental and biological samples were prepared according to EPA Method 1633A and had previously been analyzed by LC-MS/MS, allowing the GC-MS/MS method to serve as a complementary technique. Food-packaging samples were extracted with methanol containing ammonium hydroxide and analyzed for targeted PFAS. While no target PFAS were detected in the tested packaging materials, multiple GC-amenable PFAS were found in environmental samples. Fluorotelomer alcohols were the most frequently detected compounds, with wastewater and ski-wax-impacted soils showing the highest concentrations.The results demonstrate that APGC-MS/MS provides a sensitive and robust solution for the analysis of volatile PFAS classes that may be missed by LC-MS/MS alone. The method delivered accurate quantification, effective chromatographic separation, and reliable recovery in spiked samples. The authors conclude that combining APGC-MS/MS with established LC-MS/MS workflows enables a more comprehensive assessment of PFAS contamination, particularly for emerging fluorotelomer compounds and other GC-amenable PFAS that are increasingly relevant in environmental monitoring and food-packaging investigations.</div></div></div></div></div></div></section></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 26, 2026

Article

Product

Application

Academy

Video

Software

Poster

Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

DataApex

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

James Little/Mass Spec Interpretation Services

Agilent Technologies

Phenomenex

Wasson-ECE Instrumentation

Waters Corporation

Selecting the best GC for you
<blockquote>
Presenter: John Wasson
</blockquote>
<blockquote>
John Wasson has over 40 years of experience in Gas Chromatography and Chemical Instrumentation. He is President of Wasson-ECE Instrumentation, Inc.
</blockquote>

Wasson-ECE Instrumentation: Selecting the Best GC

Selecting the Best GC

Webinar will cover the following topic: Selecting the best GC for you

Whether you are new to the practice of gas chromatography (GC) or would like a refresher, the installation and care of your GC column is of the utmost importance.
Join us as we discuss proper column installation and handling for all Agilent GCs, including the Intuvo 9000. We’ll also address the common modes of column degradation and some misconceptions that people have concerning column degradation. Lastly, we’ll discuss ways that you can protect and maintain your column’s performance and extend its lifetime while minimizing instrument downtime.
<blockquote>
Presenter: Ryan Birney (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
In Ryan’s current role at Agilent, he provides application assistance and technical support for GC and Spectroscopy. He has been supporting Agilent in technical and sales roles for the past seven years. Ryan came to Agilent from industry, and has an BS degree in Biochemistry.
</blockquote>
<blockquote>
Presnter: Alex Ucci (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
In his current position at Agilent, Alex provides application assistance and technical support for sample preparation products as well as GC and LC consumables. Before he joined Agilent in 2014, Alex was a graduate student at the Pennsylvania State University researching the morphology and surface properties of aerosol particles using a wide variety of analytical techniques. He has an MS degree in chemistry.
</blockquote>

Agilent: Becoming a Better Chromatographer

Chromatography Column Care 101: From Setup to Longevity

Join us as we discuss proper column installation and handling for all Agilent GCs, including the Intuvo 9000.

Have you ever had a question about your GC or GC/MS analysis, but it seemed so simple that you thought everyone must already know the answer? We can assure you that you’re not the first nor the last person to ask.
In chromatography, the simplest of questions can have the most complex answers.
<ul>
<li>A question about which liner to use can lead to a discussion on the benefits of glass wool versus glass frits.</li>
<li>A question about how long a column should last triggers a discussion about the importance of a leak-free system, the maximum temperature limit, proper phase selection, and so on.</li>
</ul>
There’s no such thing as an easy answer, often because the answer always “depends” on many factors. To help you improve your chromatographic know-how, we’ve compiled a list of some of our most frequently asked questions. These may seem like simple questions but, in reality, they have anything but simple answers.
<blockquote>
Presenter: Mark Sinnott (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Mark Sinnott works for Agilent Technologies as a Technical Support Engineer in the Consumables and Supplies Division (CSD). In his position at Agilent, Mark performs technical support and applications assistance to gas chromatographers worldwide. He has more than 22 years of experience in gas chromatography, including environmental analysis of compounds in air, soil and water matrices, including dissolved gas analysis for the electrical industry. Mark holds a Master’s Degree in Chemistry from California State University, Sacramento, and currently resides in Twin Falls Idaho.
</blockquote>
<blockquote>
Presenter: Vanessa Abercrombie (Gas Chromatography Applications Chemist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Vanessa Abercrombie is a GC Applications Chemist at Agilent Technologies in Folsom, CA. Vanessa has a broad background in GC and GC/MS, including experience as an instrument chemist at Bode Technology in Virginia working under contract to the FBI’s Laboratory Division. Prior to that, Vanessa worked for ETS Labs in St. Helena, CA as an Analytical Chemist where she researched and developed quantitative separations by GC/MS and UHPLC for beer, wine and spirits.
</blockquote>

Agilent Technologies: GC and GC/MS Frequently Asked Questions

GC and GC/MS Frequently Asked Questions

To help you improve your chromatographic know-how, we’ve compiled a list of some of our most frequently asked questions.

The evolution of MS continues to push the limits of detection in GC. As source technologies advance, column technology must advance as well. For example, increased detection of analytes also results in increased detection of background like column bleed. Therefore, GC column technology that lowers bleed can enhance your sensitivity and data accuracy.
In this webinar, we’ll examine how column attributes like bleed, thermal stability, and inertness can translate into practical data quality improvements. When used in conjunction with a novel ion source, we’ll illustrate achievable data parameters like sensitivity limits at trace levels, retention time consistencies, and data accuracy for active analytes when combining both column and source technologies.
<blockquote>
Presenter: Vanessa Abercrombie (Gas Chromatography Applications Chemist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Vanessa Abercrombie is a GC Applications Chemist at Agilent Technologies in Folsom, CA. Vanessa has a broad background in GC and GC/MS, including experience as an instrument chemist at Bode Technology in Virginia working under contract to the FBI’s Laboratory Division. Prior to that, Vanessa worked for ETS Labs in St. Helena, CA as an Analytical Chemist where she researched and developed quantitative separations by GC/MS and UHPLC for beer, wine and spirits.
</blockquote>

Agilent Technologies: Get the Most Out of Your MS: Novel Column Chemistry Raises the Bar on Sensitivity and Data Accuracy

Get the Most Out of Your MS: Novel Column Chemistry Raises the Bar on Sensitivity and Data Accuracy

We’ll examine how column attributes like bleed, thermal stability, and inertness can translate into practical data quality improvements.

Get the Most Out of Your MS: Novel Column Chemistry

Contaminants in the sample matrix can create chromatography issues, system downtime, and unreliable test results. Having clean samples can help prevent most of these problems. There are many options for sample cleanup.
We’ll discuss the following options:
<ul>
<li>Solid phase extraction (SPE), which provides the cleanest sample.
</li>
<li>“Targeted” filtration, which can remove specific interferences from the sample matrix and provides clean samples.
</li>
</ul>
In this talk, we’ll discuss tips for selecting, developing, and implementing SPE methods. We’ll also discuss newly developed targeted filtration options and their benefits.
<blockquote>
Presenter: Golnar Javadi (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Golnar Javadi is an applications engineer providing online applications assistance and technical support for LC columns and supplies, Sample Preparation products, and Spectroscopy supplies.
</blockquote>
<blockquote>
Before joining Varian and then Agilent, Golnar worked in the pharmaceutical and nutraceutical industries on method development and quality control. She also taught college level chemistry courses for a few years.
</blockquote>
<blockquote>
Golnar then joined Varian as a technical support specialist, providing customers with method development assistance and technical support on Sample Preparation (SPE, SLE, and Filtration), HPLC, GC, ToxiLab and DAT. After the Varian-Agilent merger, Golnar joined Agilent Technologies as an Applications Engineer. She provides technical support to customers on Sample Preparation products, Liquid Chromatography columns, and Spectroscopy supplies.
</blockquote>

Agilent Technologies: Sample Cleanup: Method Development for Solid Phase Extraction and Beyond

Sample Cleanup: Method Development for Solid Phase Extraction and Beyond

We’ll discuss tips for selecting, developing, and implementing SPE methods. We’ll also discuss newly developed targeted filtration options and their benefits.

Sample Cleanup: Method Development for SPE

Leaks are problematic for any operation that uses gas tubing and fittings. Even small gas leaks can lead to safety issues, reduced productivity, and increased costs.
<ul>
<li>Leaks can introduce water and air into the gas flow and tubing.
</li>
<li>Persistent, unidentified leaks can saturate gas filters faster than expected and cause decreased sensitivity and/or elevated baselines in instrument detectors, such as GC, GC/MS, ICP-MS, or ICP-OES.
</li>
<li>Leaks can also lead to shortened lifetimes of some consumables, especially in GC systems.
</li>
<li>Further, leaks allow the gas to flow out of the fitting and can cause loss of production and revenue if trying to produce or collect and supply the gas.
</li>
</ul>
Also, if gas is being consumed at a higher rate than expected because of leakage, gas supply costs will increase. Checking for and eliminating leaks from the gas source to the terminus can reduce safety concerns and reduce costs through decreased use of cylinders or fewer refills by the gas supply company.
Join us as we explore how to identify signs of leaks, address any existing leaks, and prevent future leaks.
<blockquote>
Presenter: Alex Ucci (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
In his current position at Agilent, Alex provides application assistance and technical support for sample preparation products as well as GC and LC consumables. Before he joined Agilent in 2014, Alex was a graduate student at the Pennsylvania State University researching the morphology and surface properties of aerosol particles using a wide variety of analytical techniques. He has an MS degree in chemistry.
</blockquote>

Agilent Technologies: Sealing the Deal: Strategies for Leak-Free GC

Sealing the Deal: Strategies for Leak-Free GC

We explore how to identify signs of leaks, address any existing leaks, and prevent future leaks.

Who Should Attend:
Anyone new to SPE who wants to get familiar with the basics of SPE method development. Anyone who has a basic understanding of SPE and would like to learn how to improve their extractions. 
Key Learning Points:
<ul>
<li>Understand how to develop SPE methods from start to finish.</li>
<li>Receive general methods to use as starting points.</li>
<li>Learn when and how to optimize SPE methods, and discover new tips and tricks to make SPE method development easier.</li>
</ul>
<blockquote>
Presenter: Koen Askamp (Technical Specialist, Phenomenex)
</blockquote>
<blockquote>
Koen Askamp is a Technical Specialist at Phenomenex. He was awarded his BSc and MSc degrees in Molecular Life Sciences at Wageningen University in the Netherlands and joined Phenomenex in 2020 as Technical Sales Consultant. Koen became part of Phenomenex’s global technical support team in 2022 and assists laboratories in training chromatographers and developing analytical methods. 
</blockquote>

Phenomenex: Solid Phase Extraction Method Development

Solid Phase Extraction Method Development

Learn when and how to optimize SPE methods, and discover new tips and tricks to make SPE method development easier.

We all know the importance of performing routine maintenance on laboratory equipment. And we all know how easy it can be to forget to do it … or do it on time. Agilent GCs include Early Maintenance Feedback (EMF) counters to help manage this routinely, but many users become overwhelmed with determining the optimal limits for consumables. Set them too low and you replace consumables that still have life. Set them too high and you risk downtime and recalibrations. In addition, each combination of configuration and sample type can require its own optimal set of counters. What is a GC Operator to do?
Attend this GC Live session to learn how the latest GC instruments can track historical maintenance events and display trend plots for easy interpretation. Based on those trend plots, the EMF counters can be set at the optimum values for your instrument’s specific workflow. Bring your questions and participate in the LIVE discussion!
In this session, expect to learn:
<ul>
<li>How to automate counter resets after maintenance</li>
<li>How to view and trend your last 10 maintenance events</li>
<li>How to trend diagnostics and other data to manage each GC optimally</li>
</ul>
<blockquote>
Presenter: Saurabh Patel (Product Support, GC Applications, Agilent Technologies)
</blockquote>
<blockquote>
Saurabh Patel is a Product Support Engineer on the Technical Marketing Team at Agilent. He holds a PhD in Materials Science and Engineering from Stony Brook University. He began his career as a chemist in the Materials Characterization Lab at Merck Pharmaceuticals. Since joining Agilent in 2019, he has been focused on providing applications support for a wide range of chemical analysis using GC-GC/MS.
</blockquote>
<blockquote>
Presenter: Abbey Fausett (Applications Scientist, Gas Phase Division, Agilent Technologies)
</blockquote>
<blockquote>
Abbey Fausett is an applications scientist within Agilent’s Gas Phase Division. Her responsibilities include developing methods for emerging markets, proving existing methods on new systems, and creating material focused on new features within GC and GCMS systems. Before joining Agilent in 2011, she was an Agilent customer for 10+years, tasked with multi-technique method development, validation, and troubleshooting.
</blockquote>

Agilent: End Consumables Counting Chaos: Track and Trend for Timely GC Maintenance

End Consumables Counting Chaos: Track and Trend for Timely GC Maintenance

Attend this GC Live session to learn how the latest GC instruments can track historical maintenance events and display trend plots for easy interpretation.

Track and Trend for Timely GC Maintenance

We are excited to bring you a three-part Ask Me Anything webinar series on one of the topics you ask about most – processing data. Empower Software allows you to use two different peak detection algorithms, Traditional and ApexTrack. What are the differences between these algorithms and when might you use one versus the other? Given all the choices on the Integration tab of the Processing Method, how do you set these important parameters to ensure accurate peak integration? &nbsp;In the first part of this webinar series, we will explore the algorithms and learn how to set the parameters in a logical fashion. We will discuss:<ul><li>How both algorithms work</li><li>Starting with peak width and threshold first</li><li>Interactively setting timed events in the chromatogram</li><li>Practical examples</li><li>Empower System Policies that impact your peak detection and integration</li></ul>Please join us for a lively discussion as we explore this topic. As always, please bring your questions for this exclusive opportunity to ask our experts anything about Empower Software.<blockquote>Presenter: Neil Lander (Principal Product Manager, Informatics, Waters Corporation)Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager focusing on Informatics solutions. He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.</blockquote>

Waters Corporation: Empower Tips: Ask Me Anything About Processing Data - Part 1

Empower Tips: Ask Me Anything About Processing Data - Part 1

We will explore the algorithms and learn how to set the parameters in a logical fashion.

Empower Tips: Ask Me Anything About Processing Data

Method development and validation is a time-consuming process that requires the attention of experienced laboratory personnel. There are tools that integrate with Empower Software that dramatically reduce the time needed to build methods, evaluate results, and validate the final method. With these tools you can free up experienced laboratory personnel to carry out other tasks. These tools are compatible with older versions of Empower Software if you have Windows 10.In this webinar we will discuss:<ul><li>Method Developer Application – A new autonomous tool for method screening</li><li>Sample Set Generator – A tool that automates the creation of Instrument Methods, Method Sets and Sample Set Methods for method development and validation</li><li>Method Validation Manager – An Empower Software option that automates chromatographic method validation and performs all necessary statistical calculations</li><li>Scoring Report – A Report Method that scores and ranks the results of method development experiments making it easy to select the optimum separation</li><li>Third-Party AQbD Software – Software that integrates seamlessly with Empower Software to define the experimental region within which changes to method parameters will not significantly affect the separation</li></ul>Please join us for a lively discussion as we explore this topic. As always, please bring your questions for this exclusive opportunity to ask our experts anything about Empower Software.<blockquote>Presenter: Neil Lander (Principal Product Manager, Informatics, Waters Corporation)Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager focusing on Informatics solutions. He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.</blockquote>

Waters Corporation: Empower Tips: Ask Me Anything About Tools for Method Screening, Development, and Validation

Empower Tips: Ask Me Anything About Tools for Method Screening, Development, and Validation

In this webinar we will discuss method Developer Application – A new autonomous tool for method screening, sample Set Generator etc.

GCMS webinars focusing on Tips & Tricks - page 7