<p><strong>Solid Phase Extraction (SPE) is one of the most highly selective sample preparation methods, meaning that the targeted analytes and their matrices must be considered when choosing the correct SPE sorbent and format. Drying down the sorbent before elution is an important step.</strong></p><ul><li>Wash solvents are used to flush out unwanted compounds (i.e., contaminants). If the wash solvent is not completely removed, then residual wash solvent could contaminate the final elution.</li><li>If you do not dry the SPE sufficiently, it could make the final solution less concentrated and result in a reduction in sensitivity.</li><li>Drying helps physically break down the interactions between the sorbent and analyte for a more concentrated extract.</li></ul><p>After the wash solvent has been passed through the cartridge, continue to apply negative pressure (vacuum) or positive pressure. Use this pressure to dry the cartridge for 2 to 5 minutes (or until dry). Turn off the pressure and wipe the tips of the manifold needles to remove any residual solvent.</p><h5><strong>Notes</strong></h5><ol><li><strong>Reproducibility:</strong> Drying removes traces of residual sample/matrix and wash solvent from the sorbent. This produces a more concentrated final extract with a consistent volume and composition and yields better reproducibility and higher recoveries.</li><li><strong>Immiscibility:</strong> Drying is especially critical when using elution solvents that are immiscible with water (e.g. hexane, ethyl acetate, and methylene chloride). Residual water in the sorbent bed may prevent dissolution of the analyte in the elution solvent, resulting in low recoveries and irreproducibility.</li><li><strong>Over-drying: </strong>Avoid over-drying the sorbent, since in some cases, analyte recovery may decrease with excessive vacuum or drying times above 5 minutes. Dry cartridges look distinctly different from moist ones. Make a note of the cartridge appearance before and after conditioning. Also, you could touch the cartridge while it is drying; wet cartridges feel colder than dry cartridges.&nbsp;</li></ol>

Why Is It Necessary to Dry the SPE Sorbent Before Elution?

<p><strong>🎤 Presenter:</strong> Sarah C. Foster (William &amp; Mary)</p><p>💾 <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/redirect?event=video_description&amp;redir_token=QUFFLUhqbFk5RFV6cGdVaThIVjRSQ0N3OVFkdzE5d2Y0QXxBQ3Jtc0trUHhzWGtLeTNKcFVhelU3X1E3U3A4Z1ZHUDBkME02MDl1ajk1QnpFc25ka3ZKUlhKOFVOdDZocnAwTEZZOTZEUE84cWJTUEVUVjgyY0FvT2xBcmpkenVYOVJTd3d0a1pQNVJkSENfZXFsVmF0dF9rMA&amp;q=https%3A%2F%2Fgcms.labrulez.com%2Flabrulez-bucket-strapi-h3hsga3%2FO_2_Foster_04b38f9b88.pdf&amp;v=e5w4zwhBzRY"><strong>PDF presentation</strong></a></p><h3><strong>Abstract</strong></h3><p><strong>Fermentation is a byproduct of microbial metabolism. When beverages become fermented, the microorganisms involved produce volatile organic compounds (VOCs). It is important to examine the VOC profile of fermented beverages to understand their consumer perception and health considerations. Traditionally, VOCs are detected by gas chromatography-mass spectrometry (GC-MS). However, more complex matrices, like fermented products, benefit from the enhanced separation of comprehensive two-dimensional gas chromatography (GC×GC). This study aimed to develop an understanding of the VOCs related to different fermented beverages through a nontargeted lens via comprehensive two-dimensional gas chromatography with dual detection using flame ionization detection and time-of-flight mass spectrometry (GC×GC-FID/TOFMS).&nbsp;</strong></p><p>Data analysis focused on developing a complete VOC profile of fermented products. Moreover, analysis aimed to identify differentiating VOCs to understand differences between products and distinguish the drink matrix from the microbial matrix. Results indicate that it is possible to attribute VOCs to one component of a complex sample, creating a microbial VOC profile and a base VOC profile. It was possible to discern products from one another, including contaminated products from non-contaminated products. Data visualization consisted of Principal Component Analysis (PCA) scores and loadings plots, bar chats, Hierarchical Cluster Analysis (HCA), and Partial Least Squares Discriminant Analysis (PLS-DA). Data analysis software was capable of processing and aligning samples with high levels of biological variation, making GC×GC a promising analytical tool for market research and regulation. Future studies will aim to correlate VOCs detected via GC×GC-FID/TOFMS to the microbial genetics of fermented products.</p><h3><strong>Video Transcription</strong></h3><h4><strong>1. Introduction</strong></h4><p>Sarah Foster introduces research focused on the application of comprehensive two-dimensional gas chromatography (GC×GC) for analyzing fermented beverages.</p><p>The laboratory primarily uses <strong>GC×GC</strong> for:</p><ul><li>Separation and identification of volatile organic compounds (VOCs)</li><li>Applications in forensic sciences and food sciences</li></ul><h5><strong>Forensic Applications</strong></h5><ul><li>Fingerprint residue</li><li>Gunshot residue</li><li>Pepper spray</li><li>Other trace evidence</li></ul><h5><strong>Food Science Applications</strong></h5><ul><li>Fermented beverages</li><li>Foods claiming health benefits</li></ul><p>An additional focus of the lab is transitioning GC×GC from proof-of-concept research toward real-world field applications, including improved data interpretation and presentation.</p><h4><strong>2. Challenges in Non-Targeted GC×GC Data</strong></h4><p>Working with complex, non-targeted datasets presents several challenges:</p><ul><li>Resolution of complex coelutions</li><li>Increased number of detectable features</li><li>Expansion of compound classes</li><li>Detection of low-level analytes previously masked by abundant compounds</li><li>Difficulty in longitudinal tracking due to increased data complexity</li></ul><p>While GC×GC reveals more chemical information, interpreting this data becomes more demanding.</p><h4><strong>3. Data Processing and Statistical Tools</strong></h4><h5><strong>Software Used</strong></h5><ul><li><strong>ChromaTOF</strong> – for single chromatogram peak detection and deconvolution</li><li><strong>ChromaTOF Sync 2D</strong> – alignment software for entire datasets</li><li><strong>R statistical software</strong> – for multivariate visualization<ul><li>vegan package</li><li>ComplexHeatmap package</li></ul></li></ul><h5><strong>Advantages of Sync 2D</strong></h5><ul><li>Performs peak detection and deconvolution across all chromatograms simultaneously</li><li>Generates a unified peak table for entire datasets</li><li>Facilitates trend analysis</li></ul><h5><strong>Dimensionality Reduction Techniques Used</strong></h5><ul><li>Principal Component Analysis (PCA)</li><li>Principal Coordinate Analysis (PCoA)</li><li>Hierarchical Cluster Analysis (HCA)</li></ul><p>Each data point includes:</p><ul><li>Primary retention time</li><li>Secondary retention time</li><li>Signal intensity</li></ul><h4><strong>4. Statistical Approaches Explained</strong></h4><h5><strong>PCA (Principal Component Analysis)</strong></h5><ul><li>Uses Euclidean distance</li><li>Assumes linear variance structure</li><li>Clustering based on shared analytes</li><li>Identifies key analytes driving variance</li><li>Loadings plots explain separation patterns</li></ul><h5><strong>PCoA (Principal Coordinate Analysis)</strong></h5><ul><li>Uses non-Euclidean dissimilarity (e.g., Bray–Curtis)</li><li>Emphasizes compositional differences</li><li>Better for non-linear variance structures</li></ul><h5><strong>HCA (Hierarchical Cluster Analysis)</strong></h5><ul><li>Uses Euclidean dissimilarity (in this study)</li><li>Clustering based on:<ul><li>Presence/absence</li><li>Relative abundance</li></ul></li><li>Output: dendrogram<ul><li>Short branches = more similar</li><li>Long branches = more dissimilar</li></ul></li></ul><h4><strong>5. Research Goals</strong></h4><ul><li>Apply GC×GC-TOFMS for volatile analysis and aroma profiling of mead</li><li>Investigate impact of:<ul><li>Yeast strain</li><li>Honey concentration</li></ul></li><li>Use a non-targeted analytical approach</li><li>Extract and compare chemical features across samples</li></ul><h4><strong>6. Mead Production Overview</strong></h4><p>Mead is produced by fermenting honey with filtered water. Fruits or spices may be added. It may also be barrel-aged.</p><h5><strong>Experimental Design (Silverhand Meadery Collaboration)</strong></h5><ul><li>1-gallon batches</li><li>5 yeast strains</li><li>3 honey concentrations:<ul><li>1.5 lb/gal (low alcohol, expected dry finish)</li><li>3 lb/gal (standard)</li><li>5 lb/gal (high alcohol, expected sweet finish)</li></ul></li></ul><h5><strong>Yeast Strains Tested</strong></h5><ul><li><strong>Kveik Voss</strong> – neutral with citrus notes</li><li><strong>Munich</strong> – banana, clove (esters &amp; phenols)</li><li><strong>EC1118</strong> – neutral (sparkling wine yeast)</li><li><strong>D47</strong> – tropical/white floral</li><li><strong>Abbaye</strong> – temperature-dependent:<ul><li>Low temp: banana, tropical, spicy</li><li>High temp: raisin, fig</li></ul></li></ul><p>Fermentation lasted 9 months. Stabilizers were added post-fermentation.</p><h4><strong>7. Sample Preparation</strong></h4><h5><strong>Mead Samples</strong></h5><ul><li>3 mL in 20 mL headspace vial</li><li>0.5 g salt</li><li>5 µL (500 ppm) 1-decanol internal standard</li></ul><h5><strong>Honey Samples</strong></h5><ul><li>1.5 g honey + 1.5 mL water</li><li>Salt + internal standard</li></ul><h5><strong>Water Controls</strong></h5><ul><li>3 mL water + salt + internal standard</li></ul><p>All samples were vortexed and analyzed by GC×GC-TOFMS.</p><h4><strong>8. Instrumentation</strong></h4><p>Instrument: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=24&amp;search=Pegasus+BTX+4D"><strong>LECO Pegasus BTX 4D GC×GC-TOFMS</strong></a></p><p>Features:</p><ul><li>Dual TOFMS and FID detection</li><li>Reverse fill/flush modulator</li><li>Flow splitter</li></ul><p>The modulator:</p><ul><li>Fills loop in forward direction</li><li>Flushes to secondary column</li><li>High secondary flow split between TOFMS and FID</li></ul><h4><strong>9. Initial Observations</strong></h4><p>Key compounds identified:</p><ul><li>Furfurol (heated honey marker)</li><li>2-ethylhexanol (water)</li><li>3-methylbutanol (fermentation product)</li><li>Benzaldehyde (fermentation product)</li></ul><p>Total detected: <strong>96 volatile organic compounds</strong></p><h4><strong>10. Multivariate Results</strong></h4><h5><strong>PCA Findings</strong></h5><ul><li>Four groupings largely dictated by honey concentration</li><li>1.5 lb/gal group clustered together</li><li>3 lb/gal group tightly clustered</li><li>5 lb/gal showed pattern similar to 1.5 lb/gal</li><li>Abbey yeast formed a distinct cluster</li></ul><h5><strong>PCoA Findings</strong></h5><ul><li>Similar overall patterns</li><li>Abbey yeast more distinctly separated</li><li>Likely due to Bray–Curtis dissimilarity emphasizing compositional differences</li></ul><h5><strong>HCA + Heatmap Findings</strong></h5><ul><li>Clustering aligned with PCA/PCoA trends</li><li>Abbey yeast again formed distinct grouping</li><li>Appeared to contain similar compounds but in lower relative abundances</li></ul><p>Two major overall clusters:</p><ul><li>1.5 lb/gal group</li><li>All other meads</li></ul><h4><strong>11. Compound Trends vs Honey Concentration</strong></h4><p>Observed correlations:</p><ul><li><strong>Ethyl lactate</strong>: increased with honey concentration</li><li><strong>Furfurol</strong>: increased with honey concentration</li><li><strong>3-methylbutanol</strong>:<ul><li>Decreased with honey concentration (except Abbey strain)</li></ul></li><li><strong>Ethyl octanoate</strong>:<ul><li>Highest at 3 lb/gal</li><li>Lowest at 1.5 lb/gal</li><li>Intermediate at 5 lb/gal</li></ul></li></ul><p>Abbey strain showed unique behavior, possibly explaining its distinct clustering.</p><h4><strong>12. Conclusions</strong></h4><ul><li>GC×GC-TOFMS is highly effective for aroma profiling of mead</li><li>Dimensionality reduction techniques successfully highlighted relationships between samples</li><li>Honey concentration strongly influences volatile profile</li><li>Yeast strain (especially Abbey) significantly impacts composition</li></ul><h4><strong>13. Future Work</strong></h4><ul><li>Investigate microbial environment effects on VOC production</li><li>Link microbial kinetics data to volatile profiles</li><li>Explore compound-class-specific trends</li></ul><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote>

Application of GC×GC for the investigation of fermented beverages (Sarah C. Foster, MDCW 2026)

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 16th February 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you technical note by <strong>Agilent Technologies, </strong>presentation by<strong> MDCW / C³AL </strong>and<strong> </strong>application notes by<strong> BaySpec </strong>and<strong> Shimadzu!</strong></p><h3><strong>1. Agilent Technologies: Why Do Loss of Resolution and Retention Time Shift Occur After Installing a New GC Column?</strong></h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_loss_resolution_retention_time_shifts_gc_column_5994_8773en_agilent_e5e79a5f5e.pdf"><strong>Full PDF for download</strong></a></li></ul><p>When a new column is installed on an instrument that has been running an application for a long time, and all the instrument parameters are set to the same values as before, the resolution between a pair of critical analytes can drop unacceptably, creating concern that the column is defective.&nbsp;</p><p>The chromatograms that accompany columns like these will show that the retention times of the poorly resolved peaks on the new column have shifted. This difference indicates a change in linear velocity of the carrier gas, since the run conditions were the same.&nbsp;</p><p>Why did the retention times of those compounds shift under seemingly identical run&nbsp;conditions? The answer is that the run conditions are not identical because the columns are not truly identical. In any manufacturing process, products are built to tolerances. In the case of a GC capillary column, these tolerances include diameter and length. Even small differences in diameter and length will affect the actual velocity and flow rate through a column at a given head pressure.</p><h3><strong>2. BaySpec: Illicit Drug Detection &amp; Identification Using the Continuity™ Field Portable Mass Spectrometer</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Bay_Spec_App_Note_C101_Illicit_Drug_Detection_1_5bd32f3fe9.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The trafficking and abuse of illicit drugs inflict tremendous harm upon individuals, families, and communities throughout the United States and the world. Based on the report of the United Nations Office on Drugs and Crime, nearly 296 million people worldwide used drugs in 2022, with an estimated 64 million suffering from drug use disorders. The opioid epidemic alone has claimed over 160,000 lives in the United States over the past two years, highlighting the urgent need for effective measures to combat this scourge.</p><p>Traditional methods of drug detection, such as laboratory-based analysis, are often time-consuming, costly, and require specialized personnel. These limitations make it challenging to address the rapid and widespread nature of drug trafficking and abuse. Moreover, the constant evolution of synthetic drugs and new psychoactive substances poses a significant challenge for law enforcement and public health officials, as these substances often evade detection using conventional methods.&nbsp;</p><p>In recent years, portable mass spectrometry has emerged as a promising solution for the rapid detection and identification of illicit drugs. Unlike traditional laboratory instruments, portable mass spectrometers offer the advantage of on-site analysis, enabling law enforcement officers and first responders to quickly identify substances in real-time. This technology can be deployed in various settings, including border checkpoints, public events, and field investigations, providing a versatile and efficient tool for combating drug-related crimes. As the opioid crisis and the rise of synthetic drugs continue to pose significant challenges, the integration of portable mass spectrometry into drug detection strategies represents a critical step towards a safer and healthier society.</p><h4><strong>Instrumentation&nbsp;</strong></h4><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2218"><strong>BaySpec Continuity™ Portable Mass Spectrometer</strong></a> was used equipped with a Swab-APCI source, specifically designed for TSA-approved swabs. The samples on swabs were converted into vapors via the Swab vaporizer unit, which then were drawn into the ionization chamber by the built-in sampling pump.</p><h4><strong>Conclusions&nbsp;</strong></h4><p>In this study, we demonstrated the use of the Continuity™ Field Portable Mass Spectrometer equipped with a SwabAPCI ionization source for the detection and identification of various drugs. The capabilities of the instrument were assessed through the creation of calibration curves and surface sampling experiments using ten drug standards and four selected analytes: fentanyl, cocaine, methamphetamine, and MDMA. By serial diluting these standards in methanol, we established calibration curves and determined the instrument’s Limits of Detection (LODs) in MS2 mode. These experiments highlighted the instrument’s ability to detect trace amounts of drugs with high sensitivity and specificity.&nbsp;</p><p>The performance of the Continuity™ field portable mass spectrometer in both controlled and real-world scenarios underscores its potential as a rapid, on-site analytical tool. The results obtained from triplicate measurements reinforce the reliability of this method, making it a valuable asset for law enforcement and public health agencies in their efforts to combat drug-related issues. This study confirms that the portable MS system can quickly and effectively identify illicit substances, offering a practical solution for field investigations and real-time decision-making. As the landscape of illicit drug use continues to evolve, such advancements in portable analytical technology will be crucial in providing timely and accurate information for intervention and prevention strategies.</p><h3><strong>3. MDCW / C³AL: COUNTING DOUBLE BONDS: GC×GC–FID FOR PLASTIC PYROLYSIS OILS</strong></h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_26_Petr_Vozka_04ef50f601.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The presentation focuses on the analytical challenge of accurately quantifying olefins (double bonds) in plastic pyrolysis oils and alternative fuels derived from plastic waste. As chemical recycling processes such as pyrolysis and hydrothermal processing gain importance, detailed compositional analysis becomes essential. Pyrolysis oils are highly complex mixtures containing paraffins, iso-paraffins, olefins, cycloalkanes, aromatics, and multi-ring structures. Because olefin content strongly affects fuel stability and upgrading requirements, reliable quantification is critical.</p><p>Traditional bulk methods such as bromine number, bromine index, iodine value, FTIR, Raman, and NMR provide only total unsaturation and often suffer from interferences or limited selectivity. To achieve detailed group-type and compound-level analysis, the authors apply comprehensive two-dimensional gas chromatography with flame ionization detection (GC×GC–FID). This technique delivers high resolution, reduces co-elution, and enables classification of linear, branched, cyclic, and aromatic olefins across wide boiling ranges.</p><p>To further improve quantitative accuracy, a selective adsorption approach using silver-modified silica (Ag–SiO₂) solid-phase extraction is introduced. Olefins are selectively retained, and comparison of GC×GC–FID chromatograms before and after adsorption allows precise determination of olefin content. This method is shown to be cost-effective and reliable for samples containing more than 5 wt% olefins.</p><p>Additionally, the presentation explores chemical derivatization of olefins using dimethyl disulfide (DMDS) and other disulfides to improve structural identification and quantification. While effective for lighter gasoline-range samples, challenges remain for heavier fuels such as jet and diesel fractions. Ongoing work focuses on testing heavier disulfides, optimizing reaction conditions, and validating results using ¹H NMR spectroscopy and future TOFMS analysis.</p><h3><strong>4. Shimadzu: Analysis of Polycyclic Aromatic Hydrocarbons (PAHs) in Tattoo Inks Using GC-MS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_09_ssk_023_en_ff47795f55.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>&nbsp;GCMS-QP2020 NX supports effective analysis of PAHs in Tattoo inks.</li><li>It provides an MFDS-based GC-MS method for PAHs in tattoo inks, enabling compliance with Korean regulations.</li></ul><p>Tattoo inks have been utilized for diverse purposes throughout history, serving as cultural identifiers and means of personal expression. In contemporary society, tattooing extends beyond aesthetics and self-expression to include medical applications such as camouflage of scars and post-operative rehabilitation. Because these inks are injected directly into the dermal layer, rigorous safety and hygienic control are essential to ensure human health protection.&nbsp;</p><p>Among the regulated constituents in tattoo inks, polycyclic aromatic hydrocarbons (PAHs) are of particular concern. PAHs comprise over a hundred structurally related compounds, commonly generated through incomplete combustion processes, vehicle exhaust, and tobacco smoke. Several PAHs have been classified as carcinogenic, and chronic exposure may lead to bioaccumulation and subsequent adverse health effects.&nbsp;</p><p>In January 2022, the European Union implemented stringent restrictions through updated REACH regulations, limiting the presence of approximately 4,000 hazardous substances in tattoo and permanent make-up inks, including PAHs. 1) These regulations prohibit the use of carcinogenic, mutagenic, and sensitizing substances previously detected in such products. Since the enforcement date, only compliant inks are permitted for distribution and use within the EU.&nbsp;</p><p>In South Korea, tattoo inks were regulated as consumer chemical products under the Ministry of Environment until June 2025. Due to increasing safety concerns, they have since been reclassified as sanitary products under the authority of the Ministry of Food and Drug Safety (MFDS), resulting in the implementation of more stringent safety requirements. 2)&nbsp;</p><p>This application news introduces the analytical methodology for quantification of PAHs in tattoo inks based on the MFDS regulatory standards (Notice 2025-36). Samples were prepared in accordance with the prescribed protocol, and PAH concentrations were determined using gas chromatography– mass spectrometry (GC-MS) in selected ion monitoring (SIM) mode.</p><h4><strong>Analytical Conditions&nbsp;</strong></h4><p>For the determination of PAHs in tattoo inks, a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-QP2020+NX"><strong>GCMS-QP2020 NX</strong></a> system was employed, as shown in Figure 1. The instrumental parameters and selected ion monitoring (SIM) conditions used for PAH analysis are summarized in Table 1.</p><h4><strong>Conclusions</strong></h4><p>Quantitative analysis of PAHs in tattoo inks was performed using the GCMS-QP2020 NX. Sample preparation followed the procedure outlined in the MFDS ‘Standards and Specifications for Sanitary Products.’ All eight PAH analytes showed excellent linearity, with correlation coefficients (R²) exceeding 0.999. Recovery tests showed values between 81.6% and 115.1%, with relative standard deviations (%RSD) ranging from 0.11% to 3.13%, demonstrating good accuracy and precision. These results confirm that the GCMS-QP2020 NX is a suitable instrument for PAH analysis in tattoo inks.</p>

News from LabRulezGCMS Library - Week 08, 2026

Article

Application

Academy

Video

Presentation

The Multidimensional Chromatography (MDC) Workshop draws experts in this exciting field to share and discuss their research.

The Multidimensional Chromatography Workshop

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

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Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in industrial, government and academic laboratories.

Phenomenex

Mettler-Toledo

Agilent Technologies

Technology Networks

Thermo Fisher Scientific

C&EN

<p><strong>This webinar explains what calibration and qualification of weighing instruments are and why these related concepts are important for Good Manufacturing Practice. It also shows how to seamlessly incorporate these important concepts into a weighing process to ensure both weighing accuracy and product quality.</strong></p><p>In the highly regulated pharmaceutical and medical device industries, even the smallest inconsistencies can lead to serious product issues. As weighing instruments and applications are present in almost every stage of a manufacturing workflow, they can strongly influence the quality and integrity of the final product.</p><p>Good Manufacturing Practice or GMP is a regulation that is applicable to any pharmaceutical production process. It ensures that pharmaceutical products are consistently produced and controlled according to quality standards.</p><p><strong>Weighing according to GMP requirements</strong></p><p>In many countries, GMP has been integrated into national laws that must be followed by pharmaceutical manufacturers.</p><p><strong>Program:&nbsp;</strong></p><ul><li>What GMP is and why it is important in weighing</li><li>How to apply GMP requirements to your processes</li><li>What calibration and qualification of weighing instruments are</li><li>How equipment qualification is done in a way that satisfies GMP requirements</li><li>How METTLER TOLEDO can support you in getting weighing calibration and qualification under control</li></ul><blockquote><p><strong>Speaker: </strong>Walter Krebs (Good Weighing Practice, METTLER TOLEDO)</p></blockquote>

Mettler Toledo: Calibration and Qualification in Accordance with GMP Requirements

Calibration and Qualification in Accordance with GMP Requirements 

What calibration and qualification of weighing instruments are and why these related concepts are important for Good Manufacturing Practice

Calibration and Qualification in Accordance with GMP

<p><strong>In this webinar, we will discuss the necessity of regular updates for the Thermo Scientific Chromeleon software, as well as the transition to newer operating systems or database platforms to minimize support and security risks.</strong></p><p>To ensure the smooth operation and use of software, regular maintenance and updates are necessary. This structured software life cycle ensures that systems remain secure, efficient, and sustainable in the long term. Regular updates and continuous development are crucial to maintaining current security standards and compatibility.</p><p>Our goal is to help you use an always up-to-date, secure, and high-performance Chromeleon CDS system. While migrating a single Chromeleon workstation is often straightforward, an enterprise-wide transition can present a much greater challenge in many cases. Learn how careful planning and structured coordination can make the transition smooth. We will show you how Thermo Fisher Scientific supports you in this process and works with you to achieve a successful update of your systems.</p><p>In the second half of the webinar, Qpliance will share insights from over 100 Chromeleon configuration validations. They will focus on the practical implementation of the proven V-model using current regulations to achieve the highest audit security! Through professional project management and trustworthy collaboration, it is possible to reduce project duration by an average of 30%.</p><h4><strong>Webinar topics:</strong></h4><ul><li><strong>Starting and executing a migration</strong> or update project&nbsp;</li><li><strong>Goal definition</strong> - Do you need to improve performance, security, compatibility, or functionality? Do you need to comply with certain standards or regulations? Do you have a budget and a schedule?</li><li><strong>Assessment of the current environment</strong>, including hardware, software, network, and user profiles – Identification of security gaps, dependencies, or compatibility issues&nbsp;</li><li><strong>Implementation</strong> – What tools and options are available? What does a "best practice" approach look like?&nbsp;</li></ul><blockquote><p><strong>Presenter:</strong> Michele Musu (Technical Sales Specialist for Chromatography and Mass Spectrometry Software, Thermo Fisher Scientific)</p><p><strong>Presenter: </strong>Christian Müller (Director of Operations)</p></blockquote>

Thermo Fisher Scientific: Migration and Update of the Chromatography Data System

Migration and Update of the Chromatography Data System

The necessity of regular updates for the Thermo Scientific Chromeleon software will be discussed.

<p><strong>The ATP outlined in the USP &lt;1220&gt; and ICH guideline Q14 serves as a crucial component in the lifecycle management of analytical procedures, connecting various stages to ensure procedure fitness for use.&nbsp;</strong></p><p>This presentation will explore the key role of the ATP in determining analytical procedure attributes and performance criteria, guiding procedure design, validation, and facilitating ongoing procedure performance and continual improvement of procedure.&nbsp;</p><p>Strategies for establishing ATP performance requirements will be discussed, alongside case studies showcasing how the ATP and an enhanced approach facilitate technology change, post-approval changes and enable the adoption of analytical platform concepts across diverse product classes. The presentation will also explore the risk-based approach outlined in ICH Q14 for identifying established conditions and reporting categories for post approval changes, enhancing the understanding and implementation of ATP-driven methodologies in pharmaceutical development.</p><blockquote><p><strong>Presenter:</strong> Amanda Guiraldelli (Senior Scientist, Proteins and Oligonucleotides Analytics, RIC Group, Belgium)</p><p>Senior Scientist, Proteins and Oligonucleotides Analytics, RIC Group, Belgium , she specializes in proteins and oligonucleotides analytics at the CRO Research Institute for Chromatography Group (RIC Group) in Belgium. As a subject matter expert in biopharmaceutical analysis, she provides technical guidance on the development and validation of analytical procedures for release testing, stability studies, and characterization of biological products, while supporting ICH Q14 and AQbD-driven strategies to enhance procedure performance, collaborating with key biopharma partners.</p><p>With over a decade of experience at the United States Pharmacopeia (USP), Amanda served as scientific affairs manager and scientific liaison contributing to the development of USP standards, including USP &lt;1220&gt; on analytical procedure lifecycle, and led cross-functional initiatives to implement AQbD-driven procedure development strategies, including DoE and predictive modeling, and genotoxic trace impurities analysis, collaborating with USP’s labs, industry partners, and global regulatory bodies. Previously, Amanda worked for 8 years as a Senior Scientist at the USP Reference Standard Laboratory and as a visiting scientist at TU Berlin and Leiden University focusing on LC-HRMS-based protein characterization and method development.</p><p>She is an expert in chromatography and mass spectrometry (MS) applied to small and large molecule characterization, a frequent conference speaker, and mentor of students on AQbD-related projects at the University of Campinas (UNICAMP), Brazil. Amanda holds a Ph.D. in Analytical Chemistry from the University of São Paulo with a focus on MS-based metabolomics and chemometrics, and a B.Sc. in Pharmacy and Biochemistry.</p></blockquote>

Agilent Technologies: Navigation Pharma Regulations: Insight and Innovations

Using the Analytical Target Profile (ATP) for Efficient Procedure Lifecycle Management

This presentation will explore ATP's role in defining analytical criteria, guiding design, validation, and ensuring continuous improvement.

Using ATP for Efficient Procedure Lifecycle Management

<p><strong>The Agilent 8700 Laser Direct Infrared (LDIR) chemical imaging system enables the rapid collection of hyperspectral data in the mid-infrared (mid-IR) fingerprint region, providing detailed chemical and mineralogical insights into geologic samples.&nbsp;</strong></p><p>This technique allows for the non-destructive analysis of polished rock sections cut to the size of a standard microscope slide, generating high-resolution chemical imaging data with minimal sample preparation. By acquiring spectral information at each pixel, the LDIR system produces a comprehensive hyperspectral dataset that can be processed through spectral matching against mineral databases and statistical methods such as principal component analysis (PCA). &nbsp;The integration of LDIR technology into geologic workflows enhances mineral characterization, offering a powerful and efficient alternative to traditional spectroscopic and imaging methods for phase mapping in complex rock matrices.</p><blockquote><p><strong>Presenter: </strong>Benjamin J Southwell (Assistant Professor of Bio-Analytical Chemistry, Lake Superior State University)</p><p>Benjamin Southwell holds a bachelor’s and Master’s degree in Chemistry from Lake Superior State University (LSSU) and Central Michigan University, respectively. With a research focus on studying the analytics of cannabinoids and terpenes in cannabis products as the Coordinator for the LSSU Cannabis Center of Excellence. Currently he instructs courses in Forensic, Analytical, and Cannabis Chemistry.</p></blockquote>

Agilent Technologies: Optimize your FTIR, UV-Vis-NIR, Raman, Imaging, and Fluorescence Workflows

Mineral Identification and Phase Mapping of Geologic Samples Using Agilent 8700 Laser Direct Infrared Chemical Imaging System

Learn how the Agilent 8700 LDIR system enables rapid hyperspectral data collection in the mid-IR fingerprint region for chemical imaging.

Mineral ID & Phase Mapping with Agilent 8700 LDIR System

<p><strong>The analysis of pesticide residues in environmental and food safety samples is crucial for ensuring compliance with regulatory guidelines (label instructions) and safeguarding consumer health. Laboratories conducting food safety testing rely on GC-MS/MS, LC-MS/MS, and IC-MS to detect pesticides in EFS samples. The TSQ 9610 GC-MS/MS product line is ideally suited for this purpose, offering distinct advantages in analyzing GC-amenable pesticides across various sample types.</strong></p><p>Public environmental and food service providers, as well as contract testing laboratories, can significantly enhance sample throughput for pesticide analysis by leveraging an automated workflow. This includes QuEChERS extraction, cleanup with uSPE, and PTV injection into the GC—fully automated through the TriPlus RSH SMART robotic autosampler. The entire system is seamlessly controlled via Chromeleon CDS as a single software platform. With Intelligent Sequence and eWorkflow functionalities, it enables fully automated sample management, reporting, and LIMS data transfer, supporting 24/7 operations while reducing labor costs and improving efficiency.</p><blockquote><p><strong>Presenter: </strong>Milos Korman (Technical Sales Specialist, Thermo Fisher Scientific)</p><p>Milos Korman is an experienced Technical Sales Specialist with a strong background in analytical chemistry and extensive expertise in indirect channel sales and support. Passionate about delivering technical solutions and driving business growth in the Czech and Slovak markets.</p><p><strong>Presenter: </strong>Petra Gerhards (Regional Marketing Manager, Thermo Fisher Scientific)</p><p>Petra Gerhards is a Regional Marketing Manager for GC, GCMS and TEA in EMEA at Thermo Fisher Scientific Her background is over 34 years of experience in the field of GCMS, SPE and LCMS. Since joining the EMEA Regional Marketing Team for CCS in 2016, she has been involved in a lot of workflow solutions combining Vials and Closures with SPE solutions, GCMS and LCMS.</p></blockquote>

Thermo Fisher Scientific: Analysis of Pesticides utilizing the TSQ 9610 GC-MS/MS triple quadrupole

Analysis of Pesticides utilizing the TSQ 9610 GC-MS/MS triple quadrupole

The TSQ 9610 GC-MS/MS product line is ideally suited for pesticide analysis.

Analysis of Pesticides utilizing the TSQ 9610 GC-MS/MS

<p><strong>As interest in microplastics in the environment and food chain grows, so does the interest in the potential impacts for environmental and human health. This, coupled with strong public attention, has led to various organizations around the world looking towards the potential for regulations. While there are no specific regulations relating to the occurrence of microplastics in, for example, food, drinking water, or wastewater, an increasing number of standardized methodologies are being developed as a potential precursor to regulation.&nbsp;</strong></p><p><strong>Some examples are:</strong></p><ul><li><strong>Commission Delegated Decision (EU) 2024/1441:</strong> Supplementing Directive (EU) 2020/2184 of the European Parliament and the Council by laying down a methodology to measure microplastics in water intended for human consumption.</li><li><strong>ISO/DIS 16094-2: Water quality—Analysis of microplastic in water, Part 2:</strong> Vibrational spectroscopy methods for waters with low suspended solids content, including drinking water (Under development).</li></ul><p>In the United States, the government in California has gone one step further by mandating a four-year period of testing and reporting of microplastics levels in drinking water. California Water Boards are finalizing the sampling and testing methodologies.</p><p>Naturally, laboratories conducting microplastics analysis will be interested in these methodologies, even if they are not directly impacted. After all, standardized testing methodology can play a crucial role in harmonizing analysis, leading to more reliable data. Likewise, instrumentation providers are responsible for ensuring their products can assist users in applying these methods. With reference to the Agilent 8700 LDIR, we will explore these methodologies and how fast and automated infrared analysis of microplastics can assist.</p><p><strong>Key Learning Objectives:</strong></p><ul><li>What progress has been made in the development of standardized methodologies for microplastics?</li><li>What are some of the key challenges that remain in the implementation of these?</li><li>How might these developments impact other areas and the potential for the implementation of regulations?</li></ul><p><strong>Who Should Attend:</strong></p><ul><li>Microplastics researchers</li><li>Microplastics analysts from commercial, QA, or research labs seeking to understand key challenges in Microplastics analysis</li><li>Those interested in microplastics analysis and the development of standardized methodology around the world.</li></ul><blockquote><p><strong>Presenter: </strong>Darren Robey (Product Manager: Infrared Imaging, Agilent Technologies)</p><p><strong>Presenter: </strong>Melissa O'Meara (Forensic Science Consultant, C&amp;EN Media Group)</p></blockquote>

C&EN: Navigating Global Regulatory Frameworks for Microplastic Analysis in Drinking Water Using Vibrational Spectroscopy

Navigating Global Regulatory Frameworks for Microplastic Analysis in Drinking Water Using Vibrational Spectroscopy

With reference to the Agilent 8700 LDIR, we will explore methodologies for microplastics analysis

Vibrational Spectroscopy for Microplastic Compliance 

<div><div id="inner_content_body_text" data-content-id="394785"><p><strong>Mass spectrometry has emerged as an indispensable tool in the exploration and understanding of space. From atmospheric analysis to organic molecule detection on Mars, the role of mass spectrometry is vital in space exploration.</strong></p><p>In this webinar, our expert speaker will discuss how mass spectrometry contributes to key areas of space science, including soil and environmental sample analysis, ensuring air and water quality aboard spacecraft, and monitoring astronauts’ metabolic health.</p><p>Our speaker will also explore the innovations and breakthroughs in mass spectrometry that underscore its vital role in unraveling the mysteries of the universe and safeguarding the well-being of astronauts.</p><p><strong>In this webinar you will:</strong></p><ul><li>Hear how mass spectrometry, including <strong>GC/Q-TOF</strong>, is critical for analyzing both biological and environmental samples on space missions</li><li>Examine technological innovations in space-compatible mass spectrometers</li><li>Recognize the importance of interdisciplinary collaboration between analytical chemistry, astronaut health and space exploration</li></ul><blockquote><p><strong>Presenter: </strong>Dr. Mark Libardoni (Staff Scientist and Technical Lead - Space Science, Southwest Research Institute)</p></blockquote></div></div>

Technology Networks: The Role of Mass Spectrometry in Advancing Space Science

The Role of Mass Spectrometry in Advancing Space Science

In this webinar, our expert speaker will discuss how mass spectrometry contributes to key areas of space science

<p><strong>In this surfactant analysis seminar, we will review procedures for the identification and quantification of active principles and raw materials used in the production of cleaning products, a quick way to detect the quality of materials using FTIR technology</strong></p><blockquote><p><strong>Presenter:</strong> Rogelio García Juárez (Ingeniero de Aplicaciones Espectroscopia Molecular, Agilent Technologies)</p><p>Rogelio García is an Applications Engineer for Molecular Spectroscopy in UV-Vis, FTIR, and Raman techniques at Agilent México and Latin America. Rogelio has a Bachelor’s Degree in Pharmaceutical Chemistry and a Master´s Degree in Environmental Engineering. He has worked in several developments of methods and applications in water, soil, and air, as well as in method design for the Pharmaceutical and Food industry. In this last one, he has developed an outstanding application method for alcoholic beverages such as Tequila using FTIR technology.</p></blockquote>

Agilent Technologies: Surfactant analysis by FTIR in cleaning products

Surfactant analysis by FTIR in cleaning products

Learn to identify and quantify surfactants in cleaning products and assess material quality quickly using FTIR in this surfactant analysis seminar.

<p><strong>Pesticide residue monitoring in food is critical due to increasing regulatory complexity across the Asia-Pacific region. This webinar, scheduled for May 7th, will cover current regulatory frameworks and analytical methodologies essential for pesticide residue testing across diverse food matrices.</strong></p><p>In this webinar, we will discuss recent regulatory developments for pesticide residue analysis relevant to India and the South Asia-Pacific region. The discussion includes global regulatory considerations, methods standardization across various food matrices, and key elements of India's National Residue Monitoring Program. The necessary criteria for method validation and laboratory best practices, aligned specifically with SANTE guidelines, will be outlined.</p><p>The webinar will also cover laboratory-focused methods covering Agilent’s end-to-end analytical solutions. This includes detailed workflows using GC/MS/MS, particularly using hydrogen as a carrier gas using HydroInert ion source, and LC/MS/MS for effective detection of polar and non-polar pesticide residues. Additionally, we will explain the high-resolution GC/Q-TOF approach for comprehensive contaminant screening. The session will also address sample preparation challenges by demonstrating QuEChERS, Enhanced Matrix Removal (EMR), etc., methodologies suitable for complex food samples. Register today.</p><h4><strong>Learning Outcomes:</strong></h4><ul><li>Updates on pesticide residue regulations specific to India and the South Asia-Pacific region</li><li>Understanding India's National Residue Monitoring Program for pesticides</li><li>Analytical approaches aligned with SANTE validation requirements</li><li>Application of GC/MS/MS, LC/MS/MS, and GC/Q-TOF technologies for pesticide analysis</li><li>Sample preparation methods, including QuEChERS and Enhanced Matrix Removal (EMR) techniques for complex foods.</li></ul><h4><strong>Who Should Attend:</strong></h4><ul><li>Food safety labs, food scientists and analysts, quality teams, regulatory specialists, researchers in academia and government organizations involved in pesticide analysis and food safety, and anyone working in food testing across South Asia-Pacific region</li></ul><blockquote><p><strong>Presenter:</strong> Dr. Kaushik Banerjee (Director, ICAR-National Research Centre for Grapes, Pune)</p><p>Dr. Kaushik Banerjee is the Director of ICAR-National Research Centre for Grapes, Pune. His area of research focuses on the development of efficient analytical methods for the sensitive and confirmatory estimation of pesticide residues and mycotoxins in agricultural and food matrices, and risk assessment studies for fixation of crop-specific MRLs. Being a member of the Scientific Panels of FSSAI, he regularly contributes to the development and implementation of the food safety standards in India. Dr. Banerjee’s extensive contributions to science and community have earned him numerous national and international laurels, and fellowships of Royal Society of Chemistry, National Academy of Agricultural Sciences, ICAR and West Bengal Academy of Science &amp; Technology.</p><p>Dr. Lorna De-Leoz (Global Food Segment Director, Agilent Technologies, USA)</p><p>Dr. Lorna De Leoz has nearly 20 years of experience in the food industry. As the Global Food Segment Director, she collaborates with scientists to help develop accurate and reliable testing for food safety, quality, and authenticity. Lorna worked at the National Institute of Standards and Technology in the Mass Spectrometry Data Center for seven years. She completed her Ph.D. in Chemistry at University of California, Davis on milk oligosaccharides and glycan biomarkers analyses.</p></blockquote>

Agilent Technologies: Multi-Residue Pesticide Analysis in Food: Regulations and Analytical Approaches

Multi-Residue Pesticide Analysis in Food: Regulations and Analytical Approaches

The webinar will cover laboratory-focused methods covering Agilent’s end-to-end analytical solutions. This includes detailed workflows using GC/MS/MS

Pesticide Analysis in Food: Regulations

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>A recent study by the European Commission estimated that food fraud costs the global economy between €30 and €40 billion annually. This includes losses incurred by businesses due to product recalls, damage to brand reputation, and increased regulatory compliance costs.</strong></p><p><strong>Ongoing public demand for more information concerning food safety, authenticity, and origins continues to drive tighter regulations around the use, supply, and labelling of specific foods and ingredients – making this a primary concern for food businesses across many sectors. In many countries, food manufacturers must provide clear labelling to indicate when specific ingredients are present, including certain allergenic materials and genetically modified organisms (GMO), as well as to provide evidence of certain product claims, e.g. vegan.</strong></p><p>The average cost of a product recall can be around $10 million, and larger recalls can cost over $100 million. Overall, food fraud not only poses economic and ethical issues but also represents a serious public health risk, emphasizing the need for stringent food authenticity management and testing. Join our experts for a better understanding of food authenticity management for a better protection of the brands and the consumers.</p><h5><strong>Why Attend?</strong></h5><ul><li>Gain insights into the pressing challenges of food fraud and authenticity.</li><li>Learn from our experts about effective management strategies.</li><li>Discover the latest tools and technologies in food authenticity testing.</li><li>Engage with peers and participate in an interactive quiz</li></ul><h5><strong>Agenda:</strong></h5><ul><li><strong>What is Food Authenticity?</strong> Understanding the basics of food authenticity and its significance.</li><li><strong>Quiz: Let’s Play Together!</strong> An interactive quiz to test your knowledge on food authenticity testing and engage with the topic.<br>Impacts of Food Fraud: Why It Matters? Exploring the economic, health, and reputational impacts of food fraud on the global food industry.</li><li><strong>How to Implement Food Authenticity Management Case study</strong> and practical strategies and management practices to ensure food authenticity within your organization.</li><li><strong>Available Testing Tools and Benefits:</strong> A look at the latest testing tools available to combat food fraud and their benefits.</li><li><strong>Closing remarks and Q&amp;A</strong></li></ul><blockquote><p><strong>Presenter: </strong>Sandra Fréville (Tactical Marketing Manager EM/APJ Food Industry, Thermo Fisher Scientific MBD)</p><p>I'm the Regional Tactical Manager in the Microbiology division of Thermo Scientific dedicated to Industries. I'm graduated in biochemistry technologies and obtained a master’s degree in sale technics applied to biotechnology devices and reagents at the Superior School of Technics applied to Biology (ESTBA) in Paris. Bring and highlight solutions that help food industry to face its daily challenges and that guarantee safe products from the farm to the fork makes really sense to me. Being useful to the food industry actors by contributing to food safety culture improvement drove me to evolve for the last 20 years in sales and marketing applied to food diagnostic with an area of focus in alternative validated cultural and molecular methods for food pathogen testing.</p><p><strong>Presenter: </strong>Irene Rapti (Senior Product Manager- Molecular Solutions, Thermo Fisher Scientific)</p><p>I am a global health technology expert with 25 years of experience driving commercial excellence in the healthcare industry. Skilled in product management across both small enterprises and large corporations, I have a proven track record of managing highly regulated and innovative products, including molecular diagnostic IVD tests. My expertise encompasses Upstream and Downstream Marketing, Strategic Marketing Plans, Product Roadmaps, Product Launches, PPI, and New Product Development. Having lived and worked in the UK and Greece, I currently collaborate remotely with teams in over 20 countries, covering key regions such as Europe, the US, and Asia Pacific. I excel at motivating and engaging international teams to anticipate and respond to market trends. My educational background includes a degree in Biotechnology from London South Bank University and a Master's in Molecular Medicine from UCL.</p></blockquote></div></div></div>

Thermo Fisher Scientific: Food Integrity: Strategies to Ensure Authenticity and Combat Fraud

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