Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 8th June 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies and Shimadzu, poster by MDCW / William &amp; Mary and brochure by Thermo Fisher Scientific!<h3>1. Agilent Technologies: Analysis of Bisphenol A in PET Granules Using the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890">Agilent 8890</a>/<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=5977C">5977C</a> GC/MS System</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_bisphenol_a_pet_granules_gc_ms_system_5994_9240en_agilent_b9b78ea413.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div>Polyethylene terephthalate (PET) is commonly used in the food and beverage industry, as it is easy to recycle. Contaminants in recycled PET, including acetaldehyde, benzene, limonene, and bisphenol A (BPA), can migrate from the packaging into the contents, potentially affecting the safety and quality of the products stored inside.1 Monitoring these contaminants is crucial for ensuring the quality of recycled PET products, as they can affect the physical, chemical, and sensory properties of recycled PET, potentially leading to product defects or health concerns.1 FSSAI officially permits the use of recycled PET (rPET) in food packaging, subject to strict safety and quality standards. This regulatory change was formalized through amendments notified in March 2025, effective immediately.2 All recycled plastics used in food contact applications must comply with stringent overall and specific migration limits to ensure no harmful chemical transfer into food. The recycling processes require validated decontamination steps to reduce contaminants to safe levels. Manufacturers must certify their packaging materials under FSSAI guidelines.&nbsp;GC/MS plays a critical role in assessing the safety and suitability of recycled plastics for food‑contact applications. The method adopted in this work demonstrates the use of an Agilent 8890 GC system coupled with an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=5977C">Agilent 5977C GC/MS system</a> for quantification of BPA in PET granules.<h4>Conclusion&nbsp;</h4>This application note presents key strategies for the analysis of BPA in PET granules using GC/MS. The calibration used here ranged from 10 to 500 ng/mL, and the LOQ of the method was demonstrated at 500 ng/g for a PET sample. Repeatable results were found for six successive replicates of matrix-based standards at 100 ng/mL. Satisfactory recoveries were obtained for the tested matrix at 500 ng/g spiked concentration levels. Thus, this study demonstrates the applicability of this method for routine analysis of PET samples for identification and quantification of BPA.<h3>2. MDCW / William &amp; Mary: Characterizing PqsE’s enzymatic activity in Pseudomonas aeruginosa by Volatile Organic Compound analysis with GC×GC-TOFMS</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Zimmermann_Nicolas_a9c80563a3.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div>Pseudomonas aeruginosa is an opportunistic pathogen commonly associated with severe respiratory infections in immunocompromised patients. The pathogenic behaviors of P. aeruginosa are controlled by a cell-to-cell communication system called quorum sensing (QS). Many genes activated by QS include those responsible for forming biofilms and producing virulence factors. Interestingly, several virulence factors produced by P. aeruginosa are regulated by an interaction between a receptor, RhlR and a hydrolase, PqsE. Thus, the PqsE-RhlR interaction has become a target for antibiotic development and further characterization. Comprehensive two-dimensional gas chromatography paired with time-of-flight mass spectrometry (GC×GC-TOFMS) was chosen for metabolomic analysis as it is known for its high sensitivity and improved peak capacity. With GC×GC-TOFMS, the volatile organic compound (VOC), acetophenone, was discovered and utilized to measure dose-dependent inhibition of PqsE’s enzymatic activity in vivo by the small molecule inhibitor, Vorinostat. Furthermore, additional VOCs were identified that could add additional insight to PqsE’s function.<h4>Experimental:</h4><ul><li>GC/MS: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1097">Pegasus BTX (LECO)</a> with <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/82">LECO L-PAL3 Autosampler</a></li><li>Software: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/348">ChromaTOF Tile</a></li></ul><h4>Summary</h4>Eight VOCs identified that show statistically significant concentration differences between WT and D73A samples. The VOC acetophenone can be used to measure the enzymatic inhibition of PqsE in vivo. Vorinostat displayed a dose-dependent decrease in acetophenone levels.<h3>3. Shimadzu: Extractable Study of Container Closure Pack Used to Store Oral Drug Product Using Dynamic Headspace Technique</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_06_sip_gc_044_en_ef833b01f0.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>ASSP and simultaneous Scan/MRM analysis facilitating accurate qualitative identification and quantitation at the same time.</li><li>Dynamic headspace enables concentrating the analytes in cold trap with multi-injection count and helps to achieve higher sensitivity overstatic headspace, especially for trace level quantitation.</li></ul>Extractable and leachable (E &amp; L) studies are becoming increasingly important in the pharmaceutical industry as it is a mandatory requirement from FDA during filing of the drug product. The purpose of E &amp; L studies is to identify and evaluate possible toxicological risks. In this study, the regulatory references aim to identify traces of potential chemical substances. These substances may be harmful to patients due to their toxicity or may impact the activity of the drug product. Hence, to ensure the safety and efficacy of the drug throughout itsshelf-life, E &amp; L studies play an important role.&nbsp;<h5>What Are Extractables and Leachables?&nbsp;</h5>Extractables are organic and inorganic chemical entities that are released from a pharmaceutical packaging/delivery system, packaging component, or packaging material of construction into an extraction solvent under laboratory conditions[1].&nbsp;Leachables are foreign organic and inorganic chemical entities that are present in a packaged drug product because they have leached into the packaged drug product from a packaging/delivery system, packaging component, or packaging material of construction under normal conditions of storage and use or during accelerated drug product stability studies[1].<h4>Methods of Analysis</h4>In this method, fifteen standards were analyzed by <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMSTQ8050+NX">GCMSTQ8050 NX</a> with <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=HS-20+NX">HS-20 NX</a> (Trap) autosampler. For the method suitability, several important parameters like system suitability, linearity and precision were performed.&nbsp;<h4>Conclusion&nbsp;</h4>The chromatographic profile of solvent reflux experiment shows higher number of extractables than aqueous incubation. Furthermore, in aqueous incubation, the content of extractables is well below the AET level. Since, placebo of the ophthalmic drug product is completely aqueous, CCP used in the analysis is totally safe and can be used for the storage of Penicillin V.&nbsp;Shimadzu’s GCMS-TQ provides high scan speed of 20000 amu/sec with ASSP technology enabling simultaneous SCAN/MRM analysis which is crucial in E&amp;L study.&nbsp;Generally, if the drug product falls under parenteral and oral drug product (PODP), evaluation threshold will be at higher side due to having wider SCT. However, AET for Penicillin V was at too low to evaluate with liquid injection and static headspace technique. This has been proved with the trap headspace technology.&nbsp;To analyze the complete extractable profile with the sample screening is only possible with dynamic headspace as most of the extractables were not detected in the injection acquired with static headspace.<h3>4. Thermo Fisher Scientific: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2419">Thermo Scientific™ Orbitrap Exploris™ GC S Mass Spectrometer</a></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/br_004035_gc_orbitrap_exploris_gc_s_enviro_br004035_na_en_b1fad7f3af.pdf">Full PDF for download</a></li></ul>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2419">Thermo Scientific Orbitrap Exploris GC S</a> is a high-resolution GC-MS system designed specifically for environmental and food safety laboratories performing analysis of persistent organic pollutants (POPs). Combining Orbitrap high-resolution accurate-mass (HRAM) technology with the proven Advanced Electron Ionization (AEI) source, the platform delivers exceptional sensitivity, selectivity, and robustness for demanding applications such as dioxins, dioxin-like PCBs, PFAS, pesticides, and emerging contaminants. The system is engineered to meet regulatory requirements while supporting multiple analytical workflows on a single instrument.For dioxin and POPs analysis, the Orbitrap Exploris GC S offers performance traditionally associated with high-resolution magnetic sector instruments while providing a more streamlined and user-friendly workflow. The instrument achieves ultra-trace sensitivity, excellent repeatability, and regulatory-compliant mass resolution, supported by dedicated solutions including the TRACE Dioxin column, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/422">TriPlus RSH SMART</a> autosampler, and Chromeleon Dioxin HRAM eWorkflow software. Automated method templates, built-in quality control checks, and compliance-ready reporting simplify implementation and routine operation, enabling laboratories to increase throughput while maintaining confidence in analytical results.The platform also excels in pesticide screening and quantitation across complex food and environmental matrices. High-resolution full-scan acquisition, wide dynamic range, accurate-mass measurements, isotope pattern confirmation, and extensive spectral library matching allow confident identification and quantitation of hundreds of compounds in a single analysis. The ability to perform retrospective data analysis enables laboratories to answer new regulatory or research questions without reinjecting samples, providing flexibility for evolving analytical requirements.Supporting the mass spectrometer is a complete analytical ecosystem that includes Chromeleon Chromatography Data System for compliant quantitation workflows, Compound Discoverer software for advanced unknown identification and statistical analysis, the modular <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/483">TRACE 1600 Series GC</a>, and the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/422">TriPlus RSH SMART robotic autosampler</a>. Together, these components provide a highly automated, future-ready platform that maximizes uptime, simplifies maintenance through NeverVent and modular GC technologies, and delivers reliable HRAM data for both routine monitoring and advanced environmental research.</div></div></div></div></div></div></section></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 24, 2026

In the week of June 15, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. GERSTEL: Application Overview - V-ITEX in Practice Across Multiple Fields</h5><ul><li>Tu, 16.6.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6242">Registration</a></li></ul>Discover how V-ITEX is applied in food analysis, biotechnology, agricultural science, and metabolomics to enable sensitive, efficient, and practical analytical workflows.<h5>2. Thermo Fisher Scientific: Modernizing Dioxin Analysis for Food Control: Introducing a New GC Orbitrap</h5><ul><li>Tu, 16.6.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6256">Registration</a></li></ul>Join this webinar to learn about the Orbitrap Exploris™ GC S mass spectrometer and its application in dioxin analysis for food control laboratories.<h5>3. Agilent Technologies: Innovations and Emerging Tools in Peptide Science</h5><ul><li>Tu, 16.6.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6252">Registration</a></li></ul>Master peptide characterization and manufacturing. Discover Agilent solutions for GLP-1 API scale-up, xCELLigence cell-based bioassays, non-destructive Raman RMID, and inert LC/MS impurity profiling workflows.<h5>4. LECO: Characterization of High-Performance Polymers Using Thermal Desorption/Pyrolysis and High-Resolution Mass Spectrometry</h5><ul><li>Tu, 16.6.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6039">Registration</a></li></ul>Discover how thermal desorption and pyrolysis combined with high-resolution GC-TOFMS enable detailed characterization of high-performance plastics such as PEEK and PTFE for advanced industrial applications.<h5>5. Agilent Technologies: Becoming A Better Chromatographer: Understanding the Impact of Advanced GC Column Features for Improving Productivity and Data Quality in GC/MS Workflows</h5><ul><li>Tu, 16.6.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6253">Registration</a></li></ul>Enhance GC/MS productivity and data quality. Discover Agilent 5Q premium columns featuring Ultra Inert performance, enhanced thermal stability, ultra-fast conditioning, and extended column lifetime.<h5>6. AZoM: Optimizing Future Fuel Processes with Process Raman Spectroscopy: Applications in Hydrogen, Sustainable Aviation Fuels &amp; Carbon Capture</h5><ul><li>We, 17.6.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6209">Registration</a></li></ul>Explore how process Raman spectroscopy supports real-time monitoring and optimization of sustainable aviation fuel, hydrogen, and carbon capture processes in future energy applications.

Webinars LabRulezGCMS Week 25/2026

Developing Quick Screening Method to Identify Rice Cultivars with Unique Aromatic Features

Article

Webinars

Application

Scientific article

Science and research

Poster

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Separation Science

The Analytical Scientist

Agilent Technologies

Bruker

Shimadzu Corporation

<ul>
<li>Discuss what GC-MS/MS is and what applicaitons it is used for (Dioxins, POPs, etc.)
</li>
<li>Transition into an overview of APGC as a solution
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<li>Discuss challenges or limitations of the current GC/MS/MS technology
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<li>Share why using nitrogen as a carrier gas for GC/MS/MS analysis is optimal
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</ul>
Webinar Learning Objectives:
<ul>
<li>Understanding GC-MS/MS and Its Applications:- Discuss the principles of gas chromatography-mass spectrometry (GC-MS/MS) and its role in analytical chemistry.- Explore specific applications of GC-MS/MS, including its use in detecting dioxins, persistent organic pollutants (POPs), and other environmental contaminants.
</li>
<li>Introduction to APGC (Atmospheric Pressure Gas Chromatography):-. Provide an overview of Atmospheric Pressure Gas Chromatography (APGC) as an alternative solution to traditional GC-MS/MS.- Highlight the advantages and unique features of APGC, such as improved sensitivity, reduced matrix effects, and enhanced selectivity.
</li>
<li>Challenges and Innovations in GC-MS/MS Technology:- Identify the current challenges and limitations faced by GC-MS/MS technology.- Discuss recent innovations and advancements aimed at overcoming these challenges.- Emphasize the importance of using nitrogen as a carrier gas for GC-MS/MS analysis, considering its inertness, availability, and compatibility with various detectors.
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</ul>
<blockquote>
Prtesenter: Frank Dorman (Senior Principal Market Development Mgr, Waters Corporation)
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Frank Dorman is currently Senior Principal Market Development Manager for Waters focusing on their global environmental business and, concurrently, a Resident Scholar in the Chemistry Department at Dartmouth College in Hanover, NH where he is active in teaching analytical chemistry to undergraduates and graduate students.
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<blockquote>
In his role at Waters, Frank manages the research-focused environmental market, external collaborations, and interfaces with R&amp;D for new product development. Prior to this, Frank was an Associate Professor in the Department of Biochemistry and Molecular Biology (BMB) sat Penn State University in University Park, PA. At Penn State, Frank served as a member of the Graduate Faculty in: Biochemistry, Microbiology and Molecular Biology (BMMB), Chemistry (CHEM), Biogeochemistry (BGC) and the Forensic Science Program (FRNSC) and the Center for Molecular Toxicology and Carcinogenesis. Franks scientific interests are in gas and liquid chromatography and fundamental characterization, instrumentation and column development, as well as mass spectrometry and atomic spectroscopy as applied to trace analysis in complex sample matrices.
</blockquote>
<blockquote>
Presenter: Sarah Dowd (Principal Mass Spectrometry Applications Specialist, Waters Corporation)
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<blockquote>
Sarah Dowd joined Waters as a mass spectrometry application specialist in 2015 after earning her PhD in analytical chemistry from the University of Illinois at Urbana Champaign.
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In her eight years at Waters in the Americas application lab, Sarah has collaborated with many customers looking to expand the MS capabilities of their laboratories with Water&#39;s instruments and software. Specializing in analyses in food, environmental, and polymeric materials characterization, she has done extensive work looking at environmental contaminants with tandem quadrupole and high resolution mass spectrometers.
</blockquote>
<blockquote>
One of the hot topics for the past couple of years is the analysis of per- and polyfluoroalkyl substances (PFAS) and Sarah has collaborated with customers and other scientists within Waters to guide the next phase of PFAS testing with Waters mass spectrometry systems.
</blockquote>

Waters Corporation: APGC Roundtable: Unveiling the Pathways of GC-MS/MS Evolution

APGC Roundtable: Unveiling the Pathways of GC-MS/MS Evolution

Discuss what GC-MS/MS is and what applicaitons it is used for (Dioxins, POPs, etc.)

APGC Roundtable: Unveiling the Pathways of GC-MS/MS Evo

Join us for an insightful webinar where we will explore the critical aspects of differentiating good from bad data and how this distinction can significantly influence your results. From screening to quantification, discover the value of targeted data analysis workflows using non-targeted data with our innovative software and hardware.Find by Formula algorithm. Learn to identify the most suitable MS/MS approach for your experiments, initiate quantitation for your compounds of interest, and incorporate retention times (RTs) and MS/MS spectra into a custom database and library.This session is designed to enhance your understanding and application of Q-TOF data analysis, ensuring robust and reliable outcomes.<blockquote>Presenter: Hannah Florance (Agilent Technologies)Hannah has had multiple roles in the life sciences, starting as a protein chemist, before moving into proteomics and then metabolomics. A major part of her time working in academia involved running LC and GCMS core facilities supporting projects ranging from synthetic biology to cancer research. She is currently an LCMS applications specialist for Agilent. Presenter: Stefan Schaebler (Application Specialist LC/MS, Agilent Technologies)Stefan completed his PhD in Biology, specializing in LC-MS-based lipidomics and metabolomics. Following his doctoral studies, he joined Agilent Technologies as an LC/MS Application Specialist. In this role, Stefan focuses on small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</blockquote>

Agilent Technologies: MassHunter Masterclass Months

MassHunter Qual – The Solid Pillar in Q-TOF Data Analysis

We will explore the critical aspects of differentiating good from bad data and how this distinction can significantly influence your results.

Join our upcoming webinar on the MassHunter Quant Screener Tool to discover how to harness the power of quantitative analysis for effective screening and identification of potential suspect compounds.This session will provide in-depth guidance on creating methods from PCDL databases, evaluating result parameters, and generating straightforward summary reports. Additionally, learn how retention time (RT) prediction can enhance your screening process by significantly accelerating and simplifying large database searches.Don’t miss this opportunity to elevate your analytical capabilities!<blockquote>Presenter: &nbsp;Jonathan Spencer (Application Specialist, Agilent Technologies)Jonathan studied BSc Natural Sciences at the University of Nottingham and later went on to Sheffield Hallam University to study a MSc in Forensic Science.Following graduation, he spent 2 years as a Confirmatory Analyst in an anti-doping and forensic toxicology lab, before joining Agilent as an LC/MS Applications Scientist. At Agilent, he focuses on small molecule applications using LC/TQ and LC/Q-TOF in fields of like food, forensic and environmental analysis.</blockquote>

MassHunter Quant Screener Tool

Discover how to harness the power of quantitative analysis for effective screening and identification of potential suspect compounds. 

Join us on the hunt for the needle in the haystack!This session will delve into best practices for untargeted feature finding, focusing on achieving the optimal balance between sample coverage and processing speed using Profinder and the new MassHunter Explorer. We will explore techniques to differentiate between features and noise by applying the right filters for quality checking your data. Additionally, the webinar will cover essential aspects of compound identification, including database matching, formula generation, and structure elucidation.This is a must-attend event for anyone looking to enhance their analytical capabilities and streamline their data processing workflows.<blockquote>Presenter: &nbsp;Stefan Schaebler (Application Specialist LC/MS, Agilent Technologies)Stefan completed his PhD in Biology, specializing in LC-MS-based lipidomics and metabolomics. Following his doctoral studies, he joined Agilent Technologies as an LC/MS Application Specialist. In this role, Stefan focuses on small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</blockquote>

Finding the Needle in the Haystack Part I: From Complex Samples to Compounds of Interest

The best practices for untargeted feature finding, focusing on achieving the optimal balance between sample coverage and processing speed.

From Complex Samples to Compounds of Interest

The hunt goes on, let's find the needle in the haystack:Join us for an insightful webinar where we delve into the world of chemometrics to enhance your data interpretation skills. Learn how to select the appropriate statistical tools to make sense of your data and identify features of interest by visualizing trends and changes using various clustering and grouping approaches. We will also cover the construction of class prediction models to differentiate between sample cohorts effectively.Finally, gain a deeper understanding of your findings by mapping them onto relevant metabolomic pathways, providing essential context for your research.<blockquote>Presenter: Hannah Florance (Application Specialist LC/MS, Agilent Technologies)Hannah has had multiple roles in the life sciences, starting as a protein chemist, before moving into proteomics and then metabolomics. A major part of her time working in academia involved running LC and GCMS core facilities supporting projects ranging from synthetic biology to cancer research. She is currently an LCMS applications specialist for Agilent. Presenter: Shaun Reeksting (Application Specialist LC/MS, Agilent Technologies)Shaun completed his PhD in Biochemistry, specializing in molecular parasitology a focus in metabolomics. Following his doctoral studies, he worked in accredited industry laboratories and academia core-facilities before joining Agilent Technologies as an LC/MS Application Engineer.In this role, Shaun focuses on environmental small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</blockquote>

Finding the Needle in the Haystack Part II; All Things Chemometric

Join us for an insightful webinar where we delve into the world of chemometrics to enhance your data interpretation skills.

All Things Chemometric

Following up from our very successful previous sessions, we are delighted to offer another panel discussion in the ever-popular “Ask the Agilent Experts” series.Have you ever had a question about your GC/GCMS analysis and thought, “I have no idea what to do,” or that since the question seemed so simple, everyone must already know the answer and “Am I the only one who doesn’t know what to do?” We can assure you that you are not alone.If you have a question, we can guarantee that you are not the first…nor the last person to ask the question, especially when it comes to gases. Sometimes the simplest of questions can have the most complex answers. A question about the leaks on your mass spectrometer can lead to a discussion about how gas quality impacts sensitivity. A question about what to do when converting a method from helium to hydrogen carrier gas can lead to a discussion about column dimensions, column bleed, and what thermal stability means. There’s no such thing as an easy answer because the answer always depends on many different factors.Experts from Agilent, as well as from the field, will discuss some of the most frequently asked questions about GC and GCMS (which may seem like simple questions but have anything but simple answers). We'll also answer new questions that we hope you will submit to us.By attending this webinar, you will learn:<ul><li>How different carrier gases impact results and what to consider when converting methods from one carrier gas to another.</li><li>What is column bleed, how it relates to thermal stability, how your carrier gas can impact it, and why it matters even when using selective detectors like mass specs.</li><li>What is the difference between gas cylinders and gas generators, and should you consider using gas saving measures when using a generator.</li></ul>What you need to know:Date: 7th November, 2024Start times:<ul><li>Broadcast #1: 7th November - 7:00 PST (Los Angeles) / 9:00 CST (Chicago) / 10:00 EST (New York) / 15:00 GMT (London) / 16:00 CET (Paris/Berlin)</li><li>Broadcast #2: 7th November - 11:00 PST (Los Angeles) / 13:00 CST (Chicago) / 14:00 EST (New York)</li><li>Broadcast #3: 8th November - 8:30 IST (New Delhi) / 11:00 SGT (Singapore) / 11:00 CST (Shanghai) / 12:00 JST (Tokyo) / 14:00 AEDT (Sydney) / 16:00 NZDT (Auckland)</li></ul>Duration: Approximately 60 minutes<blockquote>Presenter: Vanessa Abercrombie (MFS, GC Applications Chemist, Agilent Technologies)Vanessa Abercrombie is a GC applications chemist at Agilent Technologies in Folsom, California, USA. Vanessa has a broad background in GC and GC/MS, including experience as an instrument chemist at Bode Technology in Virginia working under contract to the FBI’s Laboratory Division. Prior to that, Vanessa worked for ETS Labs in St. Helena, California, as an analytical chemist, where she researched and developed quantitative separations by GC/MS and UHPLC for beer, wine, and spirits. She holds a Masters of Forensic Science from The George Washington University and a Bachelor of Arts in Chemistry from Sonoma State University.Presenter: Ed Connor (Product Manager, PEAK Scientific Instruments)Ed joined PEAK in 2013 as a GC product specialist and then moved to product management. He’s been working on many collaborative projects with PEAK customers and major instrument manufacturers worldwide. The main focus of these collaborations has been looking at conversion from helium to hydrogen carrier gas for GC applications. Ed completed his Dr.Sc. at ETH Zurich in 2007 using GC-MS to look at herbivore-induced plant volatiles and their interaction with beneficial insects. He then joined the University of Zurich where his work focused primarily on floral volatile analysis using a variety of volatile collection methods, GC-MS, and GC-FID.Moderator: Diane Turner (Director &amp; Senior Consultant, Anthias Consulting Ltd)A Warwick University graduate, Diane completed her Master's in analytical chemistry and started her career in environmental chemistry, later gaining significant experience as an applications chemist. Diane’s area of research through her PhD studies at The Open University was disease diagnosis. She has developed methods and given support and training for companies in most industries around the world for more than 20 years. Diane holds voluntary roles with The Royal Society of Chemistry and other scientific organizations.</blockquote>

Separation Science: Ask the Agilent Experts Series – Part 6: The Gas Edition

Ask the Agilent Experts Series – Part 6: The Gas Edition

GC and GC/MS scientists discuss and answer more of your most frequently asked questions.

<div><div><div>Conventional GC-HRMS using EI data alone for non-target studies suffers from ambiguous identification of unknowns in NIST library searches due to less specific fragmentation, missing molecular ion signals or compound absence in the reference library. Library searches become prone for false positive assignment. To increase compound identification certainty, the addition of the molecular information, e.g., via CI is mandatory.See how a novel GC-HRMS approach with simultaneous EI and CI data acquisition in a single GC run dramatically improves the quality of information and identification certainty. Non-target studies in wastewater analysis, human metabolites, vegan food similarity and material emission prove a game-changing power of the system.Why to join this webinar:<ul><li>Understand the power of simultaneous EI and CI-HRMS data in single GC runs</li><li>Learn how to get to a safe and confident identification of unknowns in suspect and non-target GC-MS</li><li>Get to know a novel CI source with unmatched performance due to a wide selection of reagent ions and “zero” instrument downtime&nbsp;</li><li>Accelerate your analysis and post-processing time plus optimize your instrument uptime with no need of hardware switching</li></ul><blockquote>Presenter: Arnd Ingendoh (VP Business Development Applied Markets, Bruker Daltonics GmbH &amp; Co KG)Arnd Ingendoh received his PhD in biophysics 1994 in the group of Franz Hillenkamp and Michael Karas who developed and invented MALDI. Following two years at ThermoFisher and Bruker in Japan and the USA as an application specialist, he moved through various management positions at Bruker Daltonics in Germany with +15 years of service as Senior Vice President for Commercial Operations EMEA.After 25 years at Bruker, he changed to a start-up company from New Zealand, Syft Technologies, to build the European commercial organization as the Vice President Europe for real-time mass spectrometry applications like air monitoring, food quality testing and monitoring of industrial processes. In 2023, he rejoined Bruker as the VP Business Development for the Applied Mass Spectrometry division. His goal is to develop and introduce novel and potentially disruptive technologies for the applied markets. Aside of his commercial activities, Arnd had active roles in academic education, e.g. as a Guest Professor at the University of Vienna. He is author or co-author of more than 60 publications.Presenter: Sonja Klee (Produkt Manager ecTOF, TOFWERK AG)Dr. Sonja Klee is Product Manager at TOFWERK, a leading mass spectrometer manufacturer based in Switzerland. Her journey in mass spectrometry began during her undergraduate studies in Chemistry at the University of Wuppertal, Germany, where she delved into ionization and mass spectrometry fundamentals in the group of Thorsten Benter. Both fundamental research and practical applications continued through her academic studies with her PhD in Physical Chemistry in 2014 on chemical ionization mechanisms in mass spectrometry for which she received the Wolfgang-Paul-Study Award of the German Society for Mass Spectrometry (DGMS). Following this, Dr. Klee was awarded a Postdoctoral Marie Curie Fellowship to contribute to the CLOUD TRAIN Network at CERN, Switzerland.Focus of this tenure was conducting complex experiments within the EU research program "CLOUD" utilizing various TOFWERK mass spectrometers. After her two-year postdoctoral position, she continued with TOFWERK, leveraging her expertise in ionization and mass spectrometry development in several key roles, including Leading Coordinator for Ion Source Technology and Project Manager. Dr. Klee's extensive research background and industrial experience have significantly contributed to the development and introduction of the ecTOF product line, a breakthrough solution for GC-MS based compound identification. Recognized for her expertise and leadership in the field, Dr. Klee was elected as an official board member of the Swiss Group for Mass Spectrometry (SGMS) in 2023. Here, she manages the "Education" portfolio, reflecting her commitment to advancing knowledge and innovation in mass spectrometry.</blockquote></div></div></div>

Bruker: Removing Barriers in Non-target GC/MS for the Confident Identification of Unknowns

Removing Barriers in Non-target GC/MS for the Confident Identification of Unknowns

Podívejte se, jak nový přístup GC-HRMS se současným sběrem dat EI a CI v jediném GC cyklu výrazně zlepšuje kvalitu informací a jistotu identifikace.

Non-target GC/MS for the Identification of Unknowns

Following the success of our last Ask the Expert session, we’re back with a part 2 focusing on GC and GC/MS workflows. This time, our panel is discussing your questions on maintenance, troubleshooting, and column care. Whether you’re aiming to improve accuracy, solve recurring issues, maximize productivity, and extend the life of your GC or GC/MS system, this session is for you. Our expert panel will address key challenges and share best practices, tips, and tricks to keep your GC/GCMS in peak condition while answering your burning questions.Key Topics:<ul><li>How to maintain your GC/GCMS for optimal performance</li><li>Troubleshooting common issues in GC and GC/MS</li><li>Best practices for column care and extending your column’s life</li><li>Tips for improving accuracy and reproducibility in results</li><li>How to ensure efficiency and productivity across your workflows</li></ul>Who Should Attend:<ul><li>Lab managers, analysts, and technicians using GC or GC/MS</li><li>Anyone looking to optimize their GC workflows for long-term performance</li></ul><blockquote>Presenter: Dr. Anshu Kumari Singh (Technical Support Manager, Agilent Technologies)Dr. Anshu Kumari Singh is the Technical Support Manager for India in the Chemistries and Supplies Division. She has more than 20 years of experience in this industry. She is leading a team of highly qualified Individuals responsible for providing technical support to customers. She provides support to customers on queries related to applications, products and troubleshooting for GC and LC columns and Supplies. She also conducts workshops, trainings and seminars for the customers helping them in understanding the chemistry behind GC &amp; HPLC columns and Sample Preparation Products. Dr. Anshu holds a Doctorate degree from Indian Agricultural Research Institute, New Delhi and is based out of Delhi.Presenter:&nbsp; Mr. Praveen Arya (Application Engineer - GC/MS, Agilent Technologies)Praveen Arya, Application Engineer at Agilent technologies, has a commitment and appreciation for Gas-phase residue applications. In 2005, Mr. Praveen Arya completed his M.Sc. in Food Technology . After post-graduation, he served as a Senior Analyst at SGS, Gurgaon- a commercial testing laboratory for 6 years and developed expertise in Residue analysis using sophisticated chromatographic instruments such as LCMS and GCMS. After that, in 2011, He joined Agilent Technologies as an Application Engineer where he supported country-wide GCMS customers for resolving application issues and method development. He has more than 18 years of experience in residue analysis in food and environmental samples using various high end chromatographic and spectrometric techniques (GC, GCMS, GCMS/MS, TDS, Headspace, Purge &amp; trap etc.). His area of specialization includes new analytical method development and validation as per national and international guidelines.Presenter:&nbsp; Mr. Anuraj Kumar (Customer Application Engineer - GC/GCMS, Agilent Technologies)Anuraj has overall 10+ years of experience in handling Gas Phase products. Working with Agilent since 4+ years and looking for GC &amp; GCMS products as core Post Sales application engineer for PAN India. Previously he had worked with multiple pharmaceutical R&amp;D as an Research Scientist in Teva, Fresenius kabi &amp; Jubilant Life Sciences.Presenter:&nbsp; Mr. Sunil B Lakhmapure (Technical Support Specialist, Agilent Technologies)Sunil holds 19 year plus experience in the analytical field with major exposure to LC/GC with Single Quad, Triple Quad and high resolution (QToF) mass spectroscopy. Started career in Pharma R&amp;D as a scientist with hands on experience on high end instruments like LC/MS, XRD &amp; NMR. Developed &amp; published application notes using Chromatographic techniques on real world samples/issues at various levels.</blockquote>

Agilent: Decoding GC & GC/MS: Maintenance, Troubleshooting, and Best Practices

Decoding GC & GC/MS: Maintenance, Troubleshooting, and Best Practices

Challenges, best practices, tips, and tricks to keep your GC/GCMS in peak condition.

GC & GC/MS: Maintenance, Troubleshooting, Best Practices

With the need for risk assessment and testing plans looming on the horizon, join us to learn about the challenges of low-level nitrosamine detection for both LCMS and GCMS applications.We will explore the pressing questions of coming regulation, including guidance on NDSRIs, the differing use cases of the 4 Procedures of USP &lt;1469&gt; and how Shimadzu can be your partner in creating solutions to meet these requirements.As you prepare for the August 1, 2025 deadline, whether your needs will be nitrosamine discovery with LCMS-QTOF or high-sensitivity QC monitoring with headspace GC-MS/MS, Shimadzu has the hardware and applications to help you succeed.We will host a Q&amp;A session after the presentation to address any questions or comments.<blockquote>Presenter: Brian Domanski (Strategic Collaboration Scientist, Shimadzu Scientific Instruments)Brian has over 10 years working to provide LC and SFC solutions for Pharma, as well as experience with a wide range of chromatography techniques including RP, NP, HILIC, IEX, SEC/GPC, and IC. His focus also includes scalable Informatics and Data Integrity solutions.</blockquote>

Shimadzu: Are you Nitrosamine Ready? Solutions for Nitrosamine Analysis

Are you Nitrosamine Ready? Solutions for Nitrosamine Analysis

Join us to learn about the challenges of low-level nitrosamine detection for both LCMS and GCMS applications.

Solutions for Nitrosamine Analysis by LCMS and GCMS

The complete Solution for Food Analysis: Presented by Retsch, CEM, Shimadzu and EltraAccurate and rapid food analysis is becoming increasingly important as regulations become stricter and consumers become more demanding. This expert day on food analysis will give you a comprehensive overview of the optimal steps from sample preparation to analysis, familiarize you with modern methods and bring you up to date.Registration is free of charge and without obligation.<div><div><div><div><div><h3>Heavy metals and pesticides in highly processed&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</h3>In the third part of the webinar series the focus is on analytics. Each step of food processing presents a source of contamination, which is why highly processed foods (ultra-processed foods (UPF)) should be viewed critically.Heavy metals are analyzed using ICP-MS and pesticides using GCMS/MS and SFC-LCMS/MS. You have the opportunity to get in touch with device experts and discuss your questions.</div></div>In this webinar, you will learn more about:<ul><li>How to measure pesticides in difficult samples using LC-MS/MS and SFC-MS/MS</li><li>Determination of pesticides in food samples using GC-MS/MS with hydrogen as carrier gas</li><li>Challenges and solutions for heavy metal analysis</li><li>How much heavy metals are lurking in trend food products?</li></ul>Presenters: Uwe Oppermann, Stéphane Moreau, Waldemar Weber and Johannes Hesper</div></div></div>

Heavy metals and pesticides in highly processed

Heavy metals are analyzed using ICP-MS and pesticides using GCMS/MS and SFC-LCMS/MS. 

GCMS webinars focusing on GC/MS - page 17