<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 16th March 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you posters by <strong>Agilent Technologies / ASMS </strong>and <strong>MDCW / William &amp; Mary, </strong>application note by<strong> Shimadzu </strong>and other document by <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies / ASMS: Analysis of Extractables and Leachables in Catheters Using Accurate Mass Libraries and High-Resolution GC/MS and LC/MS</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ps_7250_revident_extractables_leachables_asms_2025_tp_317_en_agilent_e6d3b2e923.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Materials used in the production of medical devices contain substances that have the potential to leach from the devices. Extractables and leachables (E&amp;L) represent a range of structurally diverse compounds including antioxidants, UV absorbers, dyes, catalysts, plasticizers and polymer degradation products. Therefore, both liquid and gas chromatography techniques coupled with mass spectrometry detectors (LC/MS and GC/MS) are utilized to achieve a comprehensive chemical characterization. Application-specific accurate mass libraries combined with an efficient screening workflow, helps to increase confidence in compound identification that saves time on reviewing data while focused on E/L relevant compounds. In this study, we analyzed catheters extracts using high-resolution MS and performed data analysis using accurate mass libraries.</p><h4><strong>Experimental</strong></h4><p>Catheters from three suppliers were used in this study. Catheter A was made from PVC, and did not include DEHP, DINP, BPA or natural rubber latex. Catheter B was made with natural rubber latex base and silicone elastomer coating, and there was no claim to be phthalate or BPA free. Catheter C was a silicone-coated latex catheter made with natural rubber latex base and no DEHP or BPA. E&amp;L standards were obtained from AChemTek. Catheters were extracted with ethanol:water 1:1 solvent at 37 ˚C for 24 and 48 hours as well as 7 days and analyzed using GC/Q-TOF and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=Revident+LC%2FQ-TOF"><strong>LC/Q-TOF systems</strong></a>. The GC/MS analysis was performed using the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890+GC"><strong>8890 GC</strong></a> coupled to the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7250+GC%2FQ-TOF"><strong>7250 Q-TOF</strong></a> and the new Agilent low bleed DB-5Q column.</p><h4><strong>Results and Discussion</strong></h4><h5><strong>Accurate Mass E&amp;L Library for GC/Q-TOF</strong></h5><p>To create a new Agilent accurate mass E&amp;L Personal Compound Database Library (PCDL) for GC/Q-TOF, over 400 spectra have been collected for E&amp;L compounds. All accurate mass fragment ions in each spectrum have been annotated with formulas based on accurate mass information and isotope ratios (Figure 3). The fragment formula annotations were then verified and converted to the theoretical m/z.</p><h4><strong>Conclusions</strong></h4><ul><li>A combined workflow for the analysis of extractables and leachables by high-resolution GC/MS and LC/MS was developed using catheter extracts.</li><li>Both GC/MS and LC/MS techniques were necessary to cover a comprehensive list of E&amp;L compounds. Although several E&amp;L compounds were detected by<br>both GC/MS and LC/MS, in most cases hydrocarbons, most plasticizers, and some antioxidants were more amenable to GC/MS.</li></ul><h3><strong>2. MDCW / William &amp; Mary: A sustainable approach to nontargeted analysis using hydrogen as a carrier gas for GC×GC</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/P_13_Fisher_2c50f2c420.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Comprehensive two-dimensional gas chromatography (GC×GC) is a separation technique used to separate complex mixtures based on two different retention mechanisms, usually polarity and volatility. A nontargeted approach is commonly used for a separation technique such as GC×GC. This type of approach means that instead of looking for one or two specific components and disregarding the rest of the sample, the whole sample can be viewed exhaustively. This approach is more applicable for forensic cases especially, where the identity or composition of the sample is unknown. It is also a more sustainable approach because only one run is needed to have the full characterization of a sample instead of needing to run a sample multiple times with a different target analyte each time.</p><h4><strong>EXPERIMENTAL</strong></h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37"><strong>LECO’s Pegasus BT4D</strong></a> instrument was used for this project.</li></ul><h4><strong>RESULTS</strong></h4><p><strong>AGREEprep Comparisons:</strong> The overall scores for the two methods were 0.44 and 0.52 for helium and hydrogen, respectively. This means that the hydrogen method is more sustainable than the helium method. The criteria breakdown in Figure 6 shows the 10 different criteria used to score the methods, including sample throughput, sample preparation steps, and sustainable material usage, namely carrier gas choice.</p><h4><strong>CONCLUSIONS</strong></h4><p>The Restek EZGZ Method Translator can be used to provide three possible hydrogen methods for any given helium method. After inputting the values of a helium method, the respective hydrogen values are given for three possible methods, each prioritizing something different: translate, efficiency, and speed. The translate method was chosen as the best choice.&nbsp;</p><p>The hydrogen method achieved a higher score on the AGREEprep metric, meaning that this method is more sustainable that the helium method. This better score is solely due to the carrier gas change – everything else in the methods stayed constant.&nbsp;</p><p>Hydrogen as a carrier gas allows for higher sample throughput and faster run times. It can also be a renewable resource, made through the electrolysis of water in a laboratory using a generator.&nbsp;</p><p>A nontargeted approach is inherently greener than a targeted approach because instead of re-running a sample multiple times to analyze a different component each time, the whole picture was captured from the beginning and can be looked at through a different lens to analyze a new component.</p><h3><strong>3. Shimadzu: Analysis of PFAS in Textiles Based on EN 17681-1 and EN 17681-2</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01108_en_e04fe25939.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>Combining LCMS and GCMS enables the determination of PFAS below threshold limits in textiles.&nbsp;</li><li>Spike recovery test shows good percentage recoveries of all compounds (70–130 %) that are at or below the EU POPs threshold limit (25 ppb).</li><li>LabSolutions software offers integrated control over GCMS and LCMS for more efficient testing and data analysis.</li></ul><p>Per- and polyfluoroalkyl substances (PFAS) are used in a wide range of applications because of their useful properties, such as heat resistance and water repellency. However, PFAS are also extremely stable substances that resist degradation and accumulate in the environment, which has led to concerns about their effects on humans. Since eliminating sources of PFAS is essential to prevent them from accumulating in the environment and in living organisms, many countries are passing laws that restrict the production, distribution, and use of PFAS in products. For example, the EU POPs Regulation sets a permitted threshold of up to 0.025 mg/kg (25 ppb) for certain PFAS (including PFOA, PFOS, and PFHxS) in substances, mixtures, and products<sup>1)</sup>.&nbsp;</p><p>EN 17681 is a European standard that describes methods for determining PFAS in textiles. The EN 17681 standard is divided into two parts according to the target compounds and methods. EN 17681-1 describes an LC/MS/MS method that targets ionic PFAS, and EN 17681-2 describes a GC/MS(/MS) method that targets certain semi-volatile and volatile neutral PFAS. A 2025 revision of EN 17681-1 changed the sample preparation method for more efficient PFAS extraction<sup>2),3)</sup>.&nbsp;</p><p>This Application News describes the analysis of the target compounds shown in Table 1 based on the EN 17681-1 and EN 17681-2 standards, using both LC/MS/MS and GC/MS/MS.</p><h4><strong>&nbsp;EN 17681-1 (LC/MS/MS) Analysis Conditions</strong></h4><p>Analysis was performed using the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=LCMS-8050RX"><strong>LCMS-8050RX triple quadrupole mass spectrometer</strong></a> (Fig. 1, left). The analysis conditions used are shown in Table 3. Analyzing PFAS necessitates caution because PFAS can leach from the analytical system, the mobile phase or other sources. PFAS contamination from the system was minimized by attaching a delay column between the mixer and autosampler. The mobile phase was also prepared using PFAS grade reagents.</p><h4><strong>EN 17681-2 (GC/MS(/MS)) Analysis Conditions</strong></h4><p>Analysis was performed using a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-TQ8050+NX"><strong>GCMS-TQ8050 NX triple quadrupole mass spectrometer</strong></a> (Fig. 1, right) that was equipped with a boosted efficiency ion source (BEIS). The BEIS optimizes the electron beam focus for maximum ionization efficiency, enabling reliable analysis of PFAS at very low levels. The analysis conditions used are shown in Table 4.</p><h4><strong>Results from Analysis of Ski Wear</strong></h4><p>Old ski clothing was used as a sample. The results obtained from analyzing this sample by the EN 17681-1 (LC/MS/MS) method are shown in Fig. 11. To investigate the effect of the EN 17681- 1:2025 update, analysis was performed using both the preupdate (EN 17681-1:2022) and post-update (EN 17681-1:2025) sample preparation methods. The alkaline hydrolysis treatment used by the EN 17681-1:2025 method dramatically increased the amounts of NMeFOSE, 6:2 FTOH, 8:2 FTOH, and 10:2 FTOH that were detected, and these compounds were detected at levels above the upper limit of their respective calibration curve ranges. This shows that PFAS extraction is improved by using the updated EN 17681-1:2025 sample preparation method. Of the 33 compounds targeted by the LC/MS/MS method, 20 were detected in the sample.&nbsp;</p><p>Analyzing the sample by GC/MS/MS using the EN 17681-2 method detected 8 out of the 12 compounds targeted by the EN 17681-2 method. Of these, 8:2 FTOH and 10:2 FTOH were detected at levels above the upper limit of their respective calibration curve ranges (Fig. 12).</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The analysis of PFAS in textiles was performed according to EN 17681-1 and EN 17681-2 standards, utilizing the LCMS-8050RX and GCMS-TQ8050 NX systems. By combining LC/MS/MS analysis and GC/MS analysis, all target compounds were successfully measured at levels of 25 ppb or less. Spike recovery test at the EU POPs threshold limit (25 ppb) also demonstrated good percentage recovery (70–130 %) for all compounds. Results also showed that PFAS extraction was improved by using the EN 17681-1:2025 sample preparation method, which was updated in 2025.</p><h3><strong>4. Thermo Fisher Scientific: Fast on-line monitoring of flare gases</strong></h3><ul><li>Other document</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/fast_on_line_monitoring_of_flare_gases_wp1635_27fa9188ff.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>Measurement of flare gas streams by process mass spectrometry</strong></h4><p>Process mass spectrometry (MS) is particularly suited to the measurement of flare gas streams because it offers accurate, fast, multicomponent analysis. Table 1 shows an example of a flare gas stream containing hydrogen, nitrogen and hydrocarbons up to C6. Analysis of these eleven components will typically be performed in just 20 seconds, allowing one mass spectrometer to monitor more than one flare, depending on the distances involved. Alternatively, one MS can be used to measure process streams and flare streams, even though the composition and concentrations may be very different.</p><h4><strong>Advantages of magnetic sector MS&nbsp;</strong></h4><p>Thermo Fisher Scientific manufactures both quadrupole and magnetic sector mass spectrometers. Over thirty years of industrial experience have shown the magnetic sector based analyzer offers the best performance for industrial online gas analysis. <strong>Thermo Scientific™ Prima PRO process mass spectrometers</strong> (Figure 1) offer ideal capabilities for industrial gas analysis.&nbsp;</p><p>Key advantages of magnetic sector analyzers include improved precision, accuracy, long intervals between calibrations and resistance to contamination. Typically, analytical precision is between 2 and 10 times better than a quadrupole analyzer, depending on the gases analyzed and complexity of the mixture.&nbsp;</p><p>Neutral gas atoms and molecules are first converted into positively charged ions in the Prima PRO MS ion source. This is an enclosed type for high sensitivity, minimum background interference and maximum contamination resistance. It is a high-energy (1000 eV) analyzer that offers extremely rugged performance in the presence of gases and vapors that have the potential for contaminating the internal vacuum components. Prima PRO MS has a proven track record of monitoring high percent level concentrations of organic compounds without experiencing drift or contamination.</p><p>Ions are then accelerated through a flight tube, where they are separated by their mass to charge ratios in a magnetic field of variable strength. Since the magnetic sector mass spectrometer produces a focused ion beam at the detector, the peak shape obtained is ‘flat-topped’ and uniform response is observed over a finite mass width. As the height of the peak is directly proportional to the number of ions striking the detector it is also directly proportional to the concentration of the component being measured. As long as the measurement is taken anywhere on the peak’s flat top, high precision analysis will be observed.</p><p>The Prima PRO MS’ ability to measure over a wide dynamic range is critically important if the varying composition levels in flare gas are to be measured accurately. The Prima PRO MS has been independently evaluated by EffecTech UK, an independent specialist company providing accredited calibration and testing services to the energy and power industries for gas quality, flow and total energy metering. It is accredited to internationally recognized ISO/IEC 17025:2005 standards; this specifies the general requirements for the competence to carry out tests and/ or calibrations, including sampling.</p><h4><strong>Summary&nbsp;</strong></h4><p>Magnetic sector MS, as evidenced by the Prima PRO process MS performance, provides fast, accurate on-line analysis of flare gas composition. The inherent power of magnetic sector mass spectrometry, combined with the flexibility of GasWorks software, enables one Prima PRO MS to monitor not only flare gas streams, but also multiple process streams. Root cause fault analysis is therefore greatly facilitated, by comparing the detailed composition data from the flare gas stream with that of the various process streams. As well as complete compositional analysis, Prima PRO MS provides accurate fuel gas properties, including LHV, HHV, density, specific gravity, Wobbe Index, stoichiometric air requirement and CARI. This ensures waste gases are burnt to complete combustion and unburned pollutants are not emitted from the flare.</p>

News from LabRulezGCMS Library - Week 12, 2026

<p><strong>Wiley, a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation and learning, today announced the 2026 release of Mass Spectra of Designer Drugs, the essential GC‑MS spectral database used by forensic laboratories worldwide for the rapid identification of illicit substances.</strong></p><p>As the landscape of novel psychoactive substances (NPS) continues to evolve—with growing numbers of synthetic cannabinoids, metabolites, fentanyl analogs, pharmaceutical drugs and metabolites, derivatives, and other emerging compounds—laboratories rely on continuously updated reference data to keep pace.</p><p>The latest release includes updates to ensure comprehensive and up‑to‑date support for forensic, toxicology, and drug surveillance workflows:</p><ul><li>Addition of over <strong>700 new mass spectra</strong></li><li><strong>More than 400 new unique compounds</strong>, spanning key NPS categories such as fentanyl variants, xylazine, synthetic opioids including nitazene opioids, and cannabinoids</li><li><strong>37,075 total mass spectra and 27,900 unique chemical entities</strong> now represented in the database.</li></ul><p>“<i>The 2026 release strengthens Wiley’s position as the leading source of trusted spectral intelligence, giving laboratories the high-quality data they need to quickly and confidently identify emerging designer drugs with confidence. These enhancements directly support forensic and public health efforts as new harmful substances continue to appear</i>.” said <strong>Graeme Whitley, Senior Director, Data Science Solutions at Wiley.</strong></p><h4><strong>Purpose‑built for forensic and analytical laboratories</strong></h4><p>Engineered for the unique demands of forensic and toxicology labs, the Mass Spectra of Designer Drugs database works with most major mass-spectrometry systems and is also available as a KnowItAll database subscription. When paired with Wiley’s KnowItAll software, the database unlocks a powerful suite of advanced forensic tools, including drug classification models and Wiley’s patented MS Adaptive Search, that accelerate the identification and interpretation of both known and emerging compounds. These capabilities empower analysts to detect even novel or unusual substances with greater speed, clarity, and certainty, reinforcing the database’s role as an indispensable resource for laboratories working at the front lines of drug detection.</p><h5><strong>About </strong><a target="_blank" rel="noopener noreferrer" href="https://www.wiley.com/en-ie/"><strong>Wiley</strong></a></h5><p>Wiley (NYSE: WLY) is a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation, and learning. With more than 200 years at the center of the scholarly ecosystem, Wiley combines trusted publishing heritage with AI-powered platforms to transform how knowledge is discovered, accessed, and applied. From individual researchers and students to Fortune 500 R&amp;D teams, Wiley enables the transformation of scientific breakthroughs into real-world impact. From knowledge to impact—Wiley is redefining what's possible in science and learning.&nbsp;</p>

New release Wiley's Mass Spectra of Designer Drugs 2026 expands coverage of emerging novel psychoactive substances

<p><strong>The leaflet outlines the role and handling of analytical equipment and systems in the process of a laboratory dealing with the analysis of chemical elements and molecules. It is an introduction to topics being considered by the Eurachem Analytical Equipment and Systems Qualification Working Group.&nbsp;</strong></p><p>Various steps are required to draw a conclusion concerning the <strong>object being examined</strong> (sampling target), see Fig. 1. The core part, the analytical <strong>measurement</strong>, is based on an <strong>analytical principle</strong>. The measurement is based on a physical or chemical interaction, e.g. between light of a certain wavelength and the sample, which leads to a displayed measured value. This measurement is carried out using analytical equipment. This <strong>equipment</strong> must be <strong>fit for its intended use</strong>. Complex analytical equipment with extensive data processing is referred to as a system. Analytical equipment is used to perform the <strong>analytical method</strong>. The method must be validated to demonstrate that it is <strong>fit for purpose</strong>.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Fig_1_Analytical_principle_method_and_procedure_1_b751d25236.jpg" alt="Eurachem: Fig. 1 Analytical principle, method and procedure [1]" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Fig_1_Analytical_principle_method_and_procedure_1_b751d25236.jpg 245w," sizes="100vw" width="841" height="439"></p><h4><strong>The pyramid of quality&nbsp;</strong></h4><p>The pyramid of quality (Fig. 2) covers the <strong>analytical method</strong>. In order to produce a reproducible, <strong>reportable result</strong> that is suitable for the intended purpose, the <strong>equipment (system) </strong>(1<sup>st</sup> level) and <strong>analytical method </strong>(2<sup>nd</sup> level) must be well defined and under control, qualified or validated, respectively.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Fig_2_Pyramid_of_quality_979312ac6b.jpg" alt="Eurachem: Fig. 2 Pyramid of quality" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Fig_2_Pyramid_of_quality_979312ac6b.jpg 163w," sizes="100vw" width="708" height="677"></p><p>The equipment must have similar performance when carrying out the analyses as when developing and validating the method. Particularly in the case of methods based on libraries or training datasets, the long-term stability of the equipment must be ensured. In the case of transfer of the method to other equipment, both sets of equipment must have similar performance.&nbsp;</p><p>The performance of the equipment and the behaviour of the method are monitored by quality control measures. This is the purpose of the <strong>internal</strong> or <strong>short term</strong> (3<sup>rd</sup> level) and <strong>inter-laboratory</strong> or <strong>long term</strong> (4<sup>th</sup> level) <strong>quality assurance</strong>. When selecting the quality assurance elements, the findings from levels 1 and 2 are taken into account.&nbsp;</p><h4><strong>Is "calibration" sufficient?&nbsp;</strong></h4><p>All relevant quality assurance systems, e.g. those meeting the requirements of ISO/IEC 17025 [2] and related standards, require equipment and systems to be traceably calibrated. But is that enough to prove the fitness for the intended use of the analytical equipment?&nbsp;</p><p>According to the definition in VIM [3] calibration is the operation that, under specified conditions, establishes a relation between the <strong>quantity values</strong> with measurement uncertainties provided by measurement standards <strong>and corresponding indications</strong> with associated measurement uncertainties. It is implicitly assumed that the <strong>influencing quantities</strong> (e.g. ambient conditions, temperature, flow rates, intensities of signal sources, etc.) are constant and do not exhibit any short or long-term fluctuations or drifts. This assumes that no changes occur due to influencing quantities.&nbsp;</p><p>Nevertheless this is not the case in everyday analytical work. The influence of fluctuations or changes in the influencing quantities is evaluated through robustness investigations during method development and validation. The magnitude of the fluctuations or deviations of the equipment is specified and verified during equipment qualification.&nbsp;</p><h4><strong>The Fitness for Intended Use&nbsp;</strong></h4><p>The life cycle (Fig. 3) of new equipment to be purchased by the laboratory begins with the definition of the requirements and the intended use of the equipment.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Fig_3_Equipment_or_system_lifecycle_2919ea802d.jpg" alt="Eurachem: Fig. 3 Equipment or system lifecycle" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Fig_3_Equipment_or_system_lifecycle_2919ea802d.jpg 186w," sizes="100vw" width="887" height="742"></p><p>The <strong>User Requirement Specifications (URS) </strong>define the selection criteria and the operational ranges of the equipment parameters (influence variables), e.g. flows, temperatures, analysis volumes, etc. Considerations to support data integrity and traceability are also included in the URS. For more complex systems, the interfaces and compatibility of the components are essential.&nbsp;</p><p>All considerations made in this phase have an impact on the entire life cycle, i.e. right through to decommissioning. The stability and variability of the influence variables are monitored over the entire service life.&nbsp;</p><p>In most cases, data and metadata should remain accessible and analysable beyond the end of the equipment's life. The laboratory must use its resources as sparingly and sustainably as possible. This includes the expected service life and the costs incurred. Data integrity considerations (ALCOA+ = <strong>A</strong>ttributable, <strong>L</strong>egible, <strong>C</strong>ontemporaneous, <strong>O</strong>riginal, <strong>A</strong>ccurate, + Complete, Consistent, Enduring, Available) play a role during operation and at the end of life. These include paper records and electronic records.&nbsp;</p><p>In the pharmaceutical industry, qualification of equipment and thus ensuring that analytical equipment and systems are suitable for the intended use, is mandatory, and the respective processes are often clearly defined. Specifications are also comprehensively defined for various equipment classes.&nbsp;</p><p>The ISO standards, in particular ISO 9001 [4], ISO 10012 [5], ISO/IEC 17025 [2], ISO 17034 [6] or ISO/IEC 17043 [7], cover a very large area and a wide range of sectors. For specific sectors, an interpretation of the standards is required. Eurachem guides cover requirements for analytical chemistry and related disciplines. The Analytical Equipment and Systems Qualification Working Group is therefore developing guidance on establishing the fitness for intended use of analytical equipment and systems aimed at these disciplines.</p>

Fitness for the intended use of analytical equipment and systems

Article

Product

Application

Science and research

Poster

Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

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Wiley

Separation Science

Agilent Technologies

MDPI

GERSTEL

LECO

Thermo Fisher Scientific

Restek Corporation

<p><strong>In this session, imaging of of phamaceutical ingredients in tablets will be discussed. This technique is a tool &nbsp;that provides a means for fomulators to assess whether ingredints are evenly distributed across a tablet's surface. All steps of the analysis will be described and a commercial &nbsp;tablet will be analyzed.&nbsp;</strong></p><blockquote><p><strong>Presenter:</strong> Louis Tisinger, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)</p><p>Louis (Lou) Tisinger has a Ph.D. in Analytical Chemistry from Miami University in Oxford Ohio, where his graduate research involved the study of ATR imaging and microscope performance in vibrational spectroscopy. Most of his career has been related to pre- and post-sales support of FTIR spectrometers, microscopes, imaging systems, and thermal analytical instruments, focusing on analyzing customer samples, demonstrations, post-sales training, troubleshooting, and R&amp;D.</p></blockquote>

Agilent Technologies: Simplified Measurement of Content Distribution of Pharma Tablets

Simplified Measurement of Content Distribution of Pharma Tablets

Content distribution of entire pharma tablets can be quickly measured using the component-specific workflow of the LDIR.

Measurement of Content Distribution of Pharma Tablets

<p><strong>The impact of narrowing the IR spectral range &nbsp;from 4,000 - 650 cm-1 to 1,800 to 975 cm-1 on the identification of microplastics was investigated, using (i) three different IR microscopic techniques: FTIR-ATR, µFTIR-FPA, LDIR and (ii) multiple spectral ranges. In each case, the major types of polymers were successfully identified when the narrowed spectral spectral range was used. &nbsp;Because this is the spectral range of the LDIR, this study establishes it as a reliable technique for the characterization of microplastics.</strong></p><blockquote><p><strong>Presenter:</strong> Louis Tisinger, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)</p><p>Louis (Lou) Tisinger has a Ph.D. in Analytical Chemistry from Miami University in Oxford Ohio, where his graduate research involved the study of ATR imaging and microscope performance in vibrational spectroscopy. Most of his career has been related to pre- and post-sales support of FTIR spectrometers, microscopes, imaging systems, and thermal analytical instruments, focusing on analyzing customer samples, demonstrations, post-sales training, troubleshooting, and R&amp;D.</p></blockquote>

Agilent Technologies: How Critical is Spectral Range to Identification of Microplastics?

How Critical is Spectral Range to Identification of Microplastics?

Learn about impact of narrowing the IR spectral range from 4,000 - 650 cm-1 to 1,800 to 975 cm-1 on the identification of microplastics 

How Critical is Spectral Range to Identifiy Microplastics

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Focusing on sustainability, this presentation highlights how hollow fibre-based liquid phase microextraction &nbsp;(HF-LPME) aligns with green chemistry principles. The presentation will explore how HF-LPME reduces organic solvent use, supports miniaturization, and simplifies workflows without compromising analytical sensitivity. Real-world examples of HF-LPME applications, including the detection of novel psychoactive substances (NPS) and other compounds, will be used to illustrate practical benefits.</strong></p><h5><strong>By attending this webinar, you will:</strong></h5><ul><li>Understand how HF-LPME supports the principles of green chemistry</li><li>Identify the ways in which HF-LPME reduces the use of organic solvents, contributing to more sustainable laboratory practices</li><li>Examine real-world applications of HF-LPME, particularly in the detection of NPS and other analytes</li><li>Appreciate the practical benefits of HF-LPME in various analytical chemistry contexts</li></ul><blockquote><p><strong>Presenter: </strong>Rafael Henry-Venson (Senior Lecturer, Forensic, Toxicology/Pharmacology, University of Glasgow)</p><p>Dr Rafael Henry-Venson is a Senior Lecturer in Forensic Toxicology/Pharmacology at the University of Glasgow, with a background in Pharmaceutical Sciences/Pharmacy and a PhD in Forensic Medicine and Science. His research focuses on microextraction analytical techniques for toxicology, including the use of hollow-fibre liquid-phase microextraction (HF-LPME). With years of experience in both academic and forensic settings, Dr Henry-Venson has worked on a wide range of forensic toxicology cases. Currently, he focuses on forensic toxicology and pharmacology education.</p></blockquote></div></div></div>

SeparationScience: Green Chemistry in Forensic and Clinical Toxicology: HF-LPME in Action

Green Chemistry in Forensic and Clinical Toxicology: HF-LPME in Action

Explore HF-LPME as a sustainable microextraction technique reducing solvent use and enhancing workflow efficiency in toxicology and NPS detection.

Green Chemistry in Forensic and Clinical Toxicology: HF-LPME

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h4><strong>Ensuring Safety and Compliance with MOSH/MOAH Analysis</strong></h4><p>Join us for an insightful webinar on the critical topic of Mineral Oil Saturated Hydrocarbons (MOSH) and Mineral Oil Aromatic Hydrocarbons (MOAH) contamination in food, cosmetics, and packaging materials.</p><h4><strong>Key Topics Covered:</strong></h4><ul><li><strong>Understanding MOSH and MOAH: </strong>Learn about these complex hydrocarbon mixtures, their sources, and how they can migrate into products during processing, packaging, or storage.</li><li><strong>Health Concerns: </strong>Discover why MOAH, particularly those with three or more aromatic rings, are of significant concern due to their potentially genotoxic and carcinogenic properties.</li><li><strong>Analytical Methods:</strong> Get up-to-date with the standard method for MOSH/MOAH determination as of 2025, which is online liquid chromatography–gas chromatography with flame ionization detection (LC-GC-FID).</li><li><strong>Regulatory Landscape:</strong> Hear about the growing regulatory attention from bodies like the European Food Safety Authority (EFSA) and the German Federal Institute for Risk Assessment (BfR), and their recommendations for stricter limits and enhanced monitoring</li><li><strong>Challenges and Solutions:</strong> Understand the ongoing challenges such as matrix interference, laboratory variability, and distinguishing naturally occurring hydrocarbons from contamination. Learn about the efforts towards standardizing methods and reference materials to improve consistency and reliability.</li><li><strong>Future Directions: </strong>Explore the current efforts to refine analytical capabilities, align regulatory thresholds, and better understand the toxicological significance of different MOSH/MOAH fractions to ensure greater consumer safety and product integrity.</li></ul><h4><strong>Why Attend?</strong></h4><ul><li>Gain comprehensive knowledge about MOSH/MOAH contamination and its implications.</li><li>Stay informed about the latest regulatory updates and analytical methods.</li><li>Learn from experts about the challenges and advancements in this field.</li><li>Ensure your products meet safety standards and regulatory requirements.</li></ul><h4><strong>Who Should Attend?</strong></h4><ul><li>Food and cosmetic manufacturers</li><li>Packaging material producers</li><li>Quality assurance and regulatory affairs professionals</li><li>Laboratory analysts and researchers</li><li>Anyone interested in food safety and consumer protection</li></ul><p><i>You cannot attend the live broadcast on September 4? Please register anyway to automatically receive the link to the recording.</i></p><blockquote><p><strong>Presenter: </strong>Petra Gerhards (Regional Marketing Manager EMEAfor GC and GCMS and TEA, Thermo Fisher Scientific)</p><p>Her background is over 36 years of experience in the field of GCMS, SPE and LCMS. Since joining the EMEA Regional Marketing Team for CCS in 2016, she has been involved in a lot of workflow solutions combining Vials and Closures with SPE solutions, GCMS and LCMS.</p></blockquote></div></div></div>

Thermo Fisher Scientific: The current landscape of MOSH/MOAH analysis

The current landscape of MOSH/MOAH analysis

Join us for a webinar about MOSH and MOAH contamination in food, cosmetics, and packaging materials.

<p><strong>Discover advanced methods for detecting PFAS in household dust and complex environmental samples using high resolution time-of-flight mass spectrometry (HR-TOFMS) and spectral analysis software. Learn how HR-TOFMS enhances the identification of persistent organic pollutants (POPs)—like perfluorinated alkyl substances—at trace levels, supporting safer air, water, and soil with comprehensive screening solutions.</strong></p><blockquote><p><strong>Presenter: </strong><i>David Alonso (Applications Chemist, LECO Corporation)</i></p></blockquote>

LECO: Explore Complex Environmental Samples for PFAS-Related Compounds Using HR-TOFMS and Spectral Analysis Software Tools

Explore Complex Environmental Samples for PFAS-Related Compounds Using HR-TOFMS and Spectral Analysis Software Tools

Discover advanced methods for detecting PFAS in household dust and complex environmental samples using HR-TOFMS and spectral analysis software. 

Analyzing PFAS in Complex Samples with HR-TOFMS

<p><strong>In this Webinar, Nicole Kfoury (Application Scientist, GERSTEL Inc., USA) demonstrates how Sensory Directed Analysis (SDA) can be used to pinpoint even the faintest off-odors in complex samples.</strong></p><p>SDA enables the detection of odor-active compounds that may otherwise remain hidden from traditional analysis – from packaging materials to fermented beverages - by combining:</p><ul><li>Gas Chromatography</li><li>Mass Spectrometry</li><li>Human Nose</li></ul><p>Through two real-world case studies, you learn how to apply SDA to isolate and identify problematic compounds, even at trace levels. The webinar covers:</p><ul><li>Thin-Film SPME &amp; Twister, for high-capacity extraction</li><li>Multi-Desorption Mode, to boost sensitivity</li><li>Selectable 1D/2D-GC, for enhanced separation</li></ul><p>Whether you're facing customer complaints or seeking to ensure product quality, this webinar provides practical strategies and insights that make the invisible finally detectable.</p><p><strong>Therefore, secure your spot now!</strong></p><blockquote><p><strong>Presenter: </strong>Nicole Kfoury (Application Scientist, GERSTEL Inc., USA)</p></blockquote>

GERSTEL: Uncovering the Cause – Identifying Off-Odors with Sensory Directed Analysis

Uncovering the Cause – Identifying Off-Odors with Sensory Directed Analysis

Discover SDA for detecting hidden odor compounds in complex samples with GC-MS, sensory analysis, and real-world case studies.

Identifying Off-Odors with Sensory Directed Analysis

<p><strong>In this engaging Webinar, Nicole Kfoury (Application Scientist, GERSTEL Inc., USA) demonstrates how Sensory Directed Analysis (SDA) reveals the key compounds behind complex aromas – using real-world examples from bourbon and perfume.</strong></p><p>In addition, the webinar will showcase two powerful techniques that can be seamlessly integrated with GERSTEL ODP 4 and Olfactory Data Interpreter (ODI) software:</p><ul><li>Aroma Dilution Analysis (ADA)</li><li>Frequency Detection (e.g. Nasal Impact Frequency; NIF)</li></ul><p>You’ll learn how to identify the most impactful odor-active compounds by combining mass spectrometry and the human nose – even when compounds are below the detection limits of analytical instruments.</p><p><strong>The webinar also covers advanced techniques like:</strong></p><ul><li>Multi-Desorption Mode</li><li>Sniff &amp; Trap Function</li><li>Selectable 1D/2D-GC</li></ul><p>Whether you’re working with spirits, fragrances, or any aroma-rich product, this webinar offers practical tools to elevate your sensory analysis strategy.</p><blockquote><p><strong>Presenter: </strong>Nicole Kfoury (Application Scientist, GERSTEL Inc., USA)</p></blockquote>

GERSTEL: From Aroma to Insights – Identifying Key Sensory-Active Compounds

From Aroma to Insights – Identifying Key Sensory-Active Compounds

Learn to identify impactful aroma compounds with SDA, ADA, and NIF using GC-MS and sensory analysis in bourbon, perfume, and other products.

Identifying Key Sensory-Active Compounds

<p><strong>When analyzing complex soil and water samples for organochlorine pesticides, coextracted matrix components can contaminate the inlet and column, forcing analysts to take instruments offline for time-consuming, unplanned maintenance. Effective sample extract cleanup is the key to keeping your instruments running and generating accurate, reliable data.&nbsp;</strong></p><p><strong>Pass-through SPE using Florisil cartridges </strong>(e.g., EPA Method 3620) is a common cleanup technique, but Resprep FL + CarboPrep Plus SPE cartridges (Resprep FL+CPP)—which contain both Florisil and carbon in a dual-bed, single-cartridge format—provide a much more effective cleanup. Better cleanup means that columns last longer and instruments stay running, which increases sample throughput and lab profitability.</p><h5><strong>This webinar will cover these topics:</strong></h5><ul><li>Learn how adding carbon can improve cleanup of soil and water samples.</li><li>See how this improved cleanup improves the data collected.</li><li>Realize the reduction in routine maintenance from running cleaner extracts.</li></ul><p><strong>Join us for this valuable educational webinar!</strong></p>

Restek Corporation: Clean + Fast: Improve Productivity for Pesticides Analysis with Resprep FL + CarboPrep Plus SPE

Clean + Fast: Improve Productivity for Pesticides Analysis with Resprep FL + CarboPrep Plus SPE

Discover how Resprep FL+CPP SPE cartridges enhance soil and water sample cleanup, boosting data quality, reducing downtime, and increasing lab efficiency.

Pesticides Analysis with Resprep FL + CarboPrep Plus SPE

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>We’re thrilled to have you join us for this special event, hosted by the MDPI Journal Separations in celebration of our Special Issue, Chromatographic Analysis of Biomarkers.</strong></p><p>For over five decades, gas chromatography has played a pivotal role in biomarker discovery, enabling the precise profiling of volatile and semi-volatile compounds. Today’s webinar brings together leading voices from academia and industry to highlight cutting-edge innovations and real-world applications that are shaping the future of public health and personalized medicine.</p><p>We hope this event not only honors the journal’s legacy of excellence but also sparks new ideas, collaborations, and breakthroughs that will propel the field forward.</p><h4><strong>Registration</strong></h4><blockquote><p class="cke-user_style-important"><a target="_blank" rel="noopener noreferrer" href="https://us02web.zoom.us/webinar/register/8417551295045/WN_Q9J1MWE4TmGNGxZG1fdfsg#/registration"><strong>Register here</strong></a></p></blockquote><p>This is a <strong>FREE webinar</strong>. After registering, you will receive a confirmation email containing information on how to join the webinar. <strong>Registrations with academic institutional email addresses will be prioritized.</strong></p><p><strong>Certificates of attendance will be delivered to those who attend the live webinar.</strong></p><p>Can’t attend? Register anyway and we’ll let you know when the recording is available to watch.</p><h4><strong>Program</strong></h4><h5><strong>5:00 – 5:10 pm Chair Introduction</strong></h5><ul><li>Dr. Mark Woollam</li></ul><h5><strong>5:10 – 5:30 pm Measuring Environmental Exposure to Pollutants and Particulates in Human Samples Using Gas Chromatography</strong></h5><ul><li>Dr. Waqar Ahmed</li></ul><h5><strong>5:30 – 5:35 pm Q&amp;A</strong></h5><h5><strong>5:35 – 5:55 pm Emerging Technologies for the Untargeted Characterization of Volatile Organic Molecules in Biological Matrices</strong></h5><ul><li>Dr. David Alonso</li></ul><h5><strong>5:55 – 6:00 pm Q&amp;A</strong></h5><h5><strong>6:00 – 6:20 pm Integrated VOC Analysis from Breath to Biofluids: Building Scalable Workflows for Discovery</strong></h5><ul><li>Dr. Jonathan Grandy</li></ul><h5><strong>6:20 – 6:25 pm Q&amp;A</strong></h5><h5><strong>6:25 – 6:45 pm Discovering Breath Biomarkers of Fatigue Through Chromatography and Chemometrics</strong></h5><ul><li>Assoc. Prof. Heather Bean</li></ul><h5><strong>6:45 – 6:50 pm Q&amp;A</strong></h5><h5><strong>6:50 – 7:00 pm Closing of Webinar</strong></h5><ul><li>Dr. Eray Schulz</li></ul><blockquote><p><strong>Event Chair:</strong> Dr. Mark Woollam (Integrated Nanosystems Development Institute, Indiana University Indianapolis, Indianapolis IN, USA)</p><p><strong>Event Coordinator:</strong> Mr. Eray Schulz (Integrated Nanosystems Development Institute, Indiana University Indianapolis, Indianapolis IN, USA; Department of Chemistry and Chemical Biology, Indiana University Indianapolis, Indianapolis IN, USA)</p><p><strong>Presenter: </strong>Dr. Waqar Ahmed (School of Biological Sciences, University of Manchester, UK)</p><p><strong>Presenter: </strong>Dr. David Alonso (LECO Corporation)</p><p><strong>Presenter: </strong>Dr. Jonathan Grandy (Sepsolve Analytical Canada)</p><p><strong>Presenter: </strong>Assoc. Prof. Heather Bean (School of Life Sciences, Arizona State University, USA)</p></blockquote></div></div></div>

Sciforum: Advancements in Analysis of Biomarkers via Gas Chromatography

Advancements in Analysis of Biomarkers via Gas Chromatography

Free MDPI Separations webinar on chromatographic biomarker analysis. Discover GC advances, VOC workflows, and breath biomarker research with leading experts.

Analysis of Biomarkers via Gas Chromatography

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>The analysis of pesticide residues in environmental and food safety samples is critical to ensure regulatory compliance and protect consumer health. The TSQ 9610 GC-MS/MS product range is ideally suited for this purpose and offers significant advantages when analyzing GC-qualified pesticides in different sample types.</strong></p><p>Public environmental and food service providers and contract testing laboratories can significantly increase sample throughput for pesticide analysis by using an automated workflow. This includes QuEChERS extraction, purification with uSPE and PTV injection into the GC-MS/MS - fully automated by the TriPlus RSH SMART robotic autosampler.</p><p>The webinar will discuss various technologies to significantly reduce detection limits.</p><h5><strong>Learning points</strong></h5><ul><li>Time travel through the development of sample preparation</li><li>Automation and miniaturization in modern analytics</li><li>Performance features of the TSQ™ 9610 GC-MS/MS - robust, sensitive, time-saving</li><li>Using hydrogen as a carrier gas: opportunities and challenges</li></ul><h5><strong>Who should attend?</strong></h5><ul><li>Lab managers</li><li>Lab technicians</li><li>Technicians in charge of sample prep</li><li>GCMS operators</li></ul><p>If you cannot attend this webinar please register to receive a link to the On Demand version the following day.</p><blockquote><p><strong>Presenter: </strong>Petra Gerhards (Regional Marketing Manager EMEA for GC and GCMS and TEA, Thermo Fisher Scientific)</p><p>Her background is over 36 years of experience in the field of GCMS, SPE and LCMS. Since joining the EMEA Regional Marketing Team for CCS in 2016, she has been involved in a lot of workflow solutions combining Vials and Closures with SPE solutions, GCMS and LCMS.</p></blockquote></div></div></div>

Thermo Fisher Scientific: Journey through time in Pesticides analysis

Journey through time in Pesticides analysis

Boost pesticide residue analysis with TSQ 9610 GC-MS/MS. Discover automated QuEChERS workflows, uSPE cleanup, and advanced GC-MS/MS performance.

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