Clarity 10.2 expands instrument control capabilities with new control modules and updates the MS extension to help you work more efficiently.<h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity</a> 10.2 highlights</h4><ul><li>New and updated control modules</li><li>Improved MS data import and export</li><li>Obsolete hardware support ended</li></ul><h4>Instrument control modules</h4>Clarity 10.2 introduces new instrument control modules from Annuo (AS-3117, FAS-3823) and updated instrument controls form Sykam and Ecom.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Instrument_control_modules_5de26782b0.jpg" alt="DataApex: Instrument control modules" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Instrument_control_modules_5de26782b0.jpg 228w," sizes="100vw" width="380" height="260"><h4>MS data import/export improvements</h4>Clarity improves MS data exchange, especially for *.cdf files. MS instruments now support export and import of multiple spectral data and non-spectral signal data in the same CDF file. Import also better handles uniform sampling information, m/z Step values, scale factors, and file names with non-ASCII characters. Exporting individual chromatogram signals from MS instruments is now available through a separate Export Chromatogram dialog.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg" alt="DataApex: MS data import-export improvements" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg 228w," sizes="100vw" width="378" height="259"><h4>Obsolete hardware support terminated</h4>Due to changes in Windows driver security requirements, this update discontinues support for obsolete hardware, including INT7, INT9, U-PAD, U-PAD2, and CB20.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg" alt="DataApex: Obsolete hardware support terminated" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg 228w," sizes="100vw" width="378" height="259"><blockquote>Explore the complete list of all changes, fixes, and additions in version 10.2.👉<a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1">See the complete changelog&nbsp;</a></blockquote>

Clarity Chromatography Software 10.2 released!

Traditional EI library searching works exceptionally well when the unknown compound is already present in the spectral library. However, analytical chemists frequently encounter compounds that are structurally related to library entries but are not exact matches. NIST's EI Hybrid Search addresses this challenge by combining conventional spectral matching with mass-shifted fragment alignment, allowing the identification of analogs, derivatives, and novel compounds that may not exist in the database.This guide summarizes the workflow presented by James Little and demonstrates how to use NIST 26 Hybrid Search in conjunction with the Chromatogram Window and MS Interpreter to obtain more meaningful structural information from unknown EI GC-MS spectra.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/paper/33370">You can download PDF Handout for this guide HERE</a></blockquote><h4>Why Hybrid Search Matters</h4>Conventional EI library searching relies on direct matching between an unknown spectrum and spectra stored in a library. Hybrid Search expands this concept by allowing fragment ions to be matched even when they are shifted by a consistent mass difference (Δm). This enables the software to recognize compounds that differ by substituents or structural modifications.Key advantages include:<ul><li>Identification of structurally related compounds not present in the library</li><li>Detection of analogs, derivatives, and emerging compounds</li><li>Integration of exact fragment matches and mass-shifted matches into a single score</li><li>Improved interpretation of unknowns through proposed structural modifications</li><li>Enhanced confidence when molecular weight information is available</li></ul>Although Hybrid Search does not require the molecular ion to be present, performance improves significantly when the molecular weight can be estimated or constrained. In these cases, the observed mass difference between the unknown and library compounds can often be translated directly into a plausible chemical modification.<h4>Configuring Hybrid Search</h4>Before performing a search, the Hybrid Search settings should be configured within the NIST Library Search window.Recommended settings:<ul><li>Select the Similarity search mode</li><li>Enable Hybrid Search</li><li>Keep the In Spectrum option checked under normal circumstances</li><li>Allow the software to estimate the molecular weight automatically</li><li>If the estimated molecular weight appears incorrect, manually enter a nominal molecular weight</li><li>Select all relevant libraries (NIST, Wiley, user libraries, etc.)</li><li>Save the configuration for future use</li></ul>The selected molecular weight used to constrain the search is displayed in the lower-right corner after the search is completed.<h4>Optimizing the Results Display</h4>Hybrid Search produces several unique parameters that are not shown in the default results table.Additional columns should be added by right-clicking within the results table and selecting Properties. Recommended columns include:<ul><li>DeltaMass</li><li>dForm</li><li>pctRelForm</li><li>o.Match (equivalent to the traditional EI Normal Match score)</li></ul>Without these parameters, much of the structural interpretation power of Hybrid Search is lost.<h4>Working with Spectra from the Chromatogram Window</h4>Currently, the Chromatogram Window performs standard EI library searching. When a potentially interesting unknown is encountered:<ul><li>Perform the normal EI search in the Chromatogram Window</li><li>Send the spectrum to the standalone Library Search module</li><li>Perform a Hybrid Search using the enhanced Hybrid Search functionality</li></ul>This workflow combines rapid screening with advanced structural interpretation.<h4>Understanding Key Hybrid Search Parameters</h4><h5>DeltaMass (Δm)</h5>DeltaMass represents the mass difference between the unknown compound and the matched library compound.A consistent Δm across multiple high-scoring hits often indicates a specific structural modification.<h5>dForm</h5>dForm provides a proposed elemental composition that explains the observed mass difference.Examples include:<ul><li>H–1F</li><li>CH₂</li><li>O–1</li><li>C₁H₃F</li></ul>These transformations can suggest likely chemical modifications between the library compound and the unknown.<h5>pctRelForm</h5>New in NIST 26, pctRelForm estimates how frequently a given elemental transformation occurs relative to the most common transformation (CH₂ = 100%).Interpretation:<ul><li>High values indicate chemically plausible and commonly observed transformations</li><li>Very low values suggest the proposed transformation may be accidental or unlikely</li></ul><h5>o.Match</h5>Represents the traditional EI match score and allows comparison between standard searching and Hybrid Search results.<h4>Case Study: Identifying a Fluorinated Unknown</h4>The presentation demonstrates the identification of an unknown compound with a proposed molecular weight of 152 Da.Hybrid Search returned several high-scoring hits with consistent evidence suggesting fluorine substitution:Hit #1<ul><li>Library MW: 134</li><li>DeltaMass: +18</li><li>dForm: H–1F</li><li>Interpretation: Addition of fluorine</li></ul>Hit #5<ul><li>Library MW: 138</li><li>DeltaMass: +14</li><li>dForm: CH₂</li><li>Interpretation: Related fluorinated analog</li></ul>Hit #6<ul><li>Library MW: 168</li><li>DeltaMass: –16</li><li>dForm: O–1</li><li>Interpretation: Structurally consistent fluorinated compound</li></ul>Multiple independent hits converged on the same conclusion: the unknown was likely a fluorinated analog of known aromatic compounds.This illustrates the major strength of Hybrid Search: identifying structural relationships even when the exact compound is absent from the library.<h4>Moving from Hybrid Search to Structural Interpretation</h4>Once a plausible structure is identified:<h5>Step 1 – Export the Structure</h5>From the Hybrid Search results:<ul><li>Right-click the best hit</li><li>Use Send To → Default Structure Editor</li><li>Open the structure in a drawing program such as ChemSketch</li><li>Copy the proposed structure to the clipboard</li></ul><h5>Step 2 – Open MS Interpreter</h5>Within MS Interpreter:<ul><li>Paste the proposed structure</li><li>Load the unknown spectrum</li><li>Compare predicted fragmentation with observed ions</li><li>Evaluate isotope patterns and fragment assignments</li></ul><h5>Step 3 – Validate the Proposal</h5>Indicators of a good structural proposal include:<ul><li>Consistent isotope ratios</li><li>Logical fragmentation pathways</li><li>Agreement between observed and predicted fragment ions</li><li>Multiple Hybrid Search hits supporting the same structural modification</li></ul>In the example presented, MS Interpreter showed excellent agreement between the proposed fluorinated structure and the observed EI spectrum, although the exact positions of the fluorine and methyl substituents on the aromatic ring could not be definitively assigned.<h4>Best Practices</h4><ul><li>Always review DeltaMass, dForm, and pctRelForm together</li><li>Do not rely solely on the highest match score</li><li>Give greater weight to transformations supported by multiple independent hits</li><li>Use molecular weight information whenever possible</li><li>Confirm structural hypotheses using MS Interpreter</li><li>Consider Hybrid Search as a structure-elucidation tool rather than simply a library search tool</li></ul><h4>Conclusion</h4>NIST 26 Hybrid Search significantly extends the capabilities of conventional EI library searching by identifying structural relationships between unknown compounds and library entries. Through the use of DeltaMass calculations, elemental transformation analysis (dForm), and statistical plausibility metrics (pctRelForm), Hybrid Search provides valuable clues for elucidating compounds that are absent from spectral libraries.When combined with MS Interpreter, it becomes a powerful workflow for the characterization of unknowns, analogs, degradation products, metabolites, and emerging compounds in EI GC-MS analysis.

Lib Search: Similarity EI Hybrid Search for Spectra Sent from Chromatogram Window

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 22nd June 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you brochure by Agilent Technologies, application note by Shimadzu and posters by MDCW / William &amp; Mary and Waters Corporation / ASMS!<h3>1. Agilent Technologies: Operational efficiency for your GC and GC/MS labs with the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B">Agilent 8890B gas chromatography system</a></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/br_8890b_gc_5994_9205en_agilent_fb5db29527.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div><h4>Analyze more samples every day with faster cycle times&nbsp;</h4>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B">8890B GC </a>provides faster maximum oven temperature ramps and cooldown rates for conventional dual-channel GC. If you want even faster cycle times, an optional rapid cooling fan is available.&nbsp;<h4>Achieve excellent repeatability across multiple injections&nbsp;</h4>Consistent retention time and area count performance are the cornerstone of what you can expect from the 8890B GC. The system also meets all specifications required for regulatory methods such as USP Method &lt;467&gt; (residual solvents).<h4>Shine a new light on your connections and components&nbsp;</h4>Make maintenance easier and faster with a built-in oven light that illuminates the internal space on the 8890B GC. That means you can perform tasks like troubleshooting and column installation in less time—and with fewer errors.<h4>Boost GC performance with capillary flow technology&nbsp;</h4><ul><li>Backflush significantly reduces timing between injections, increasing productivity.&nbsp;</li><li>Purged Ultimate unions provide leak-free connections, reducing downtime.&nbsp;</li><li>Flow splitters enable data collection from up to three detectors.&nbsp;</li><li>New CFT calculators let you download calculated setpoints to your method—avoiding time-consuming, error-prone manual input.&nbsp;</li><li>Multidimensional chromatography:&nbsp;<ul><li>Deans Switch facilitates heart cutting, enabling resolution of trace compound in complex matrices.&nbsp;</li><li>GC x GC flow modulation enables multidimensional chromatography without the need for cryogen</li></ul></li></ul><h4>Helium conservation module&nbsp;</h4>Extend the life of your helium tanks by up to 30 times. The Agilent helium conservation module allows you to use helium for your GC runs and switch to a different gas (typically nitrogen) when your GC is idle. That means you can achieve better control of laboratory operating expenses and avoid workflow disruptions.<h4>Alternative carrier gas support&nbsp;</h4>Alternative carrier gases like hydrogen and nitrogen are popular low-cost options.&nbsp;The Agilent Hydrogen Sensor Module Series 2 option adds built-in peace of mind when operating with H2 gas.&nbsp;The Agilent HydroInert source minimizes sensitivity loss and spectral anomalies associated with H2. It also:&nbsp;<ul><li>Maintains spectral fidelity, even for compounds highly susceptible to hydrogenation.&nbsp;</li><li>Improves peak shape for high-boilers, especially polycyclic aromatic hydrocarbons (PAHs)</li></ul><h3>2. MDCW / William &amp; Mary: Decomposition Analysis Using Differing Data Processing Methods to Identify Volatile Organic Compounds</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/P_25_Weina_2ae94f0998.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div>When a body decomposes it emits volatile organic compounds (VOCs). VOCs from decomposing remains have been studied before,1 however there is a gap that remains in the knowledge on VOCs that evolve from submerged decomposing remains. 2 In this study, submerged animal tissue was tested to see how the VOCs can be utilized in forensic settings.&nbsp;This study used data obtained last summer using comprehensive two-dimensional gas chromatography – time-of-flight mass spectrometry (GC×GC-TOFMS). Pigs (Sus scrofa domesticus) are often used as analogs in decomposition studies due to similarities with humans. 3 In this study, pork belly samples were submerged in mason jars filled with water and stored at different temperatures. The GC×GC-TOFMS instrument was used to collect odor from above water samples for a period of twelve days.GC×GC is often used to analyze complex odor profiles. When analyzing samples with GC×GC, there is a lack of standardization to process the data acquired from time trials. There is a need to discover effective ways to track VOCs for chemical identification and longitudinal analysis.The goal of this research was to compare different software approaches to analyze GC×GC longitudinal data to achieve accurate analyte identification, representation of data over time, and effective class characterization.<h4>Methods</h4>For the first four days, 5 mL of water was taken and run on the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37">GC×GC-TOFMS</a>. Thereafter, the samples were sampled and run every three days until day twelve. Data were analyzed initially using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/41">ChromaTOF</a> (LECO Corporation). The samples were then analyzed using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/348">ChromaTOF Tile </a>and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1873">ChromaTOF Sync 2D</a> to compare how they can be used in a forensic setting.Peak tables were curated in Tile and Sync 2D. Then, ChromaTOF was used as a guide to confirm which peaks were identified correctly. If the compound was correctly identified, the peak would be accepted or kept on the table. If not correctly identified, the peak would either be rejected or deleted. Once the tables were complete from the different software approaches, they were exported to Excel for further comparison.In excel, the relevant hits that were identified as decomposition VOCs were compared across the software approaches. The compounds that were most commonly found were compared to existing literature on decomposition VOCs. From there, two tables were built; where one table was compounds confirmed with literature and the other table was compounds not confirmed with literature.Comparison between software approaches included looking at different criteria to see which method was the most effective and efficient. The criteria included how long the software approach took, the number of compounds found in each software approach, the accuracy of peak area in the software approach compared to ChromaTOF data, and principal component analysis (PCA) comparison to see which software approach was best used for forensic practice or research.<h4>Conclusions</h4>Sync 2D showed the capability of showing trends in decomposition compounds<ul><li>This software approach can be used in research environment where longitudinal data is needed to determine the trends of decomposition data&nbsp;</li><li>Best purpose: research applications requiring longitudinal tracking&nbsp;</li></ul>Coefficient of Variance’s and Fold Change’s PCA plots showed their ability for clear class differentiation&nbsp;<ul><li>The two software approaches can be used to distinguish water containing decomposition in a crime scene&nbsp;</li><li>Best purpose: comparison at a single point and time [detailed analysis]&nbsp;</li></ul>Fisher Ratio showed a proficiency in identifying top differentiating compounds and showed aptitude for class differentiation&nbsp;<ul><li>The software approach would be helpful for cursory analysis for crime scene evidence&nbsp;</li><li>Best purpose: quick comparison of biggest difference for swift identification</li></ul><h3>3. Shimadzu: Determination of Ester and Linolenic Acid Methyl Ester Contents in Biodiesel According to EN 14103:2020</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_05_sca_180_054_en_93d1029b72.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=2060">NexisTM GC-2060</a> provides reliable analysis of biodiesel samples regarding their ester and linolenic acid methyl ester contents using hydrogen as a cost-effective carrier gas&nbsp;</li><li>It delivers excellent repeatability and provides appropriate safety measures for the use of hydrogen as carrier gas&nbsp;</li><li>The optional multi-mode injection unit (MMI) offers performance equivalent to a conventional split-splitlessinjection unit (SPL), significantly reducing maintenance downtime</li></ul>Biofuels play an important role in enabling countriesto meet their greenhouse gas reduction targets. They can be produced from a range of raw materials, including plant oils, animal fats, and used cooking oils. Biodiesel is mainly being produced from rapeseed, soybean, and palm oils. Due to this diversity of feedstocks, continuous quality control is necessary as the quality of the raw material has an enormousimpact on the quality of the biodiesel.&nbsp;The EN 14103:2020 describes the determination of total ester content and linolenic acid methyl ester content in biodiesel by means of gas chromatography with flame ionization detection (GC-FID). The total ester content covers a range of fatty acid methyl esters (FAME) from C6 to C24, and linolenic acid methyl ester is investigated separately as interfering reactive compound that might influence long-term stability of the biodiesel. According to the standard, the total ester content must be greater than 90 % (m/m) and the linolenic acid methyl ester content shall be between 1 and 15 % (m/m)1.This study shows the analysis of biodiesel originating from rapeseed,soybean, and palm oil using the Nexis GC-2060.<h4>Multi-Mode Injection Unit as Alternative&nbsp;</h4>Shimadzu’s multi-mode injection unit (MMI) offers reliable splitsplitless mode functionality over a broad range of carbon numbers. It allows analysis of biodiesel samples with high repeatability and provides chromatographic results comparable to those measured with SPL as dedicated split-splitless injection unit. The use of MMI significantly shortens maintenance downtime from tens of minutes for a classical split-splitless injection unit to just a few minutes. Figure 3 gives a direct comparison of an exemplary rapeseed-based biodiesel sample measured with SPL (top) and MMI (bottom).<h4>Conclusion</h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=2060">Nexis GC-2060</a> provides reliable analysis of biodiesel samples regarding their ester and linolenic acid methyl ester content according to EN 14103:2020, covering the various ester types commonly in use. It allows repeatable analysis using hydrogen as a cost-effective carrier gas. The optional multi-mode injection unit (MMI) can be selected as alternative to a classical splitsplitlessinjection unit (SPL).<h3>4. Waters Corporation / ASMS: Putting the (Atmospheric) Pressure on Forever Chemicals: A Targeted Analysis of GC Amenable PFAS using APGC–MS/MS</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009413_dfa4082b45.pdf">Full PDF for download</a></li></ul>This poster presents a targeted analytical method for the determination of gas chromatography (GC)-amenable PFAS compounds using atmospheric pressure gas chromatography coupled with tandem mass spectrometry (APGC-MS/MS). The study addresses a key limitation of conventional LC-MS/MS methods, which are highly effective for many PFAS but less suitable for more volatile species such as fluorotelomer alcohols (FTOHs), fluorotelomer acrylates (FTAcr), and fluorotelomer acetates (FTOAc). By incorporating GC-MS/MS analysis, laboratories can obtain a more complete characterization of PFAS contamination across environmental, biological, and food-contact materials.The analytical workflow utilized an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890">Agilent 8890 gas chromatograph</a> equipped with an autosampler and coupled to a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/554">Waters Xevo TQ Absolute tandem mass spectrometer</a> operated with APGC ionization in positive-ion mode. Separation was performed on an Rtx-200 capillary column, while data acquisition and quantification were managed using <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544">waters_connect software</a>. Unlike traditional electron ionization (EI), APGC generated intact protonated molecular ions, significantly improving sensitivity and selectivity for GC-amenable PFAS. A method covering 35 PFAS compounds was developed, achieving lower limits of quantification (LLOQs) of 0.025–0.1 ng/mL for most analytes.Several sample types were evaluated, including wastewater, surface water, soil, fish tissue, shrimp, and food-packaging materials. Environmental and biological samples were prepared according to EPA Method 1633A and had previously been analyzed by LC-MS/MS, allowing the GC-MS/MS method to serve as a complementary technique. Food-packaging samples were extracted with methanol containing ammonium hydroxide and analyzed for targeted PFAS. While no target PFAS were detected in the tested packaging materials, multiple GC-amenable PFAS were found in environmental samples. Fluorotelomer alcohols were the most frequently detected compounds, with wastewater and ski-wax-impacted soils showing the highest concentrations.The results demonstrate that APGC-MS/MS provides a sensitive and robust solution for the analysis of volatile PFAS classes that may be missed by LC-MS/MS alone. The method delivered accurate quantification, effective chromatographic separation, and reliable recovery in spiked samples. The authors conclude that combining APGC-MS/MS with established LC-MS/MS workflows enables a more comprehensive assessment of PFAS contamination, particularly for emerging fluorotelomer compounds and other GC-amenable PFAS that are increasingly relevant in environmental monitoring and food-packaging investigations.</div></div></div></div></div></div></section></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 26, 2026

Article

Product

Application

Academy

Video

Software

Poster

Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

DataApex

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

James Little/Mass Spec Interpretation Services

Separation Science

Agilent Technologies

Phenomenex

Thermo Fisher Scientific

Wasson-ECE Instrumentation

Wiley

SciY/Mestrelab Research

<h3>PhenoAcademy Webinars - Gas Chromatography Series</h3>
<h4>Gas Chromatography Tips and Tricks</h4>
<ul>
<li>Find new best practices for gas management, and how to keep your system clean
</li>
<li>Identify active sites and impurities within the column and system
</li>
<li>Learn how to properly cut your column, and make the best connections
</li>
</ul>
<blockquote>
Presenter: Duilio Romanello (Senior Technical Specialist, Phenomenex)
</blockquote>
<blockquote>
Duilio Romanello graduated with his Bachelors of Science in Pharmaceutical Chemistry and Technology from University of Bologna. Duilio then joined Phenomenex in 2008 as an Inside Technical Sales Consultant becoming Team Leader in Italy for GC/SPE in 2010 and then for the Environmental &amp; Food Team.
</blockquote>
<blockquote>
Since 2016 he has been covering the role of Account Manager for the South of Italy working remotely and acting as GC Specialist. Since November 2023 he is Senior Technical Specialist for the Technical team at Phenomenex.
</blockquote>
<blockquote>
Presenter: Zachary Woodward (Senior Technical Specialist, Phenomenex)
</blockquote>
<blockquote>
Zachary Woodward is a Senior Technical Specialist with Phenomenex, Inc, assisting laboratories with method development in the bio-pharma, environmental, and food industries. Zachary spent his formative years developing HPLC and GC methods with a pharmaceutical lab in Albany, NY, after which he developed HPLC and SPE methods in the clinical setting here in Southern California. Zachary received his B.Sci. in Chemistry from the College of William and Mary, was awarded his Master’s in Chemistry at San Diego State University, and is happy to speak with you today!
</blockquote>
<blockquote>
Presenter: Lucia Geis Asteggiante (Senior Technical Specialist, Phenomenex)
</blockquote>
<blockquote>
Lucia is a Senior Technical Specialist that has recently joined Phenomenex’s Global Technical Team. She has a broad experience in the field of Analytical Chemistry with a particular focus on LC chromatography coupled with mass spectrometry. Lucia comes from a strong academic and regulatory background with experiences ranging from method development and analysis of small molecules to large protein complexes. She gained her Ph.D. at the University of Maryland - College Park, USA and did her post-doctoral work at the University of Oxford, UK. During her time as a researcher, she has authored/co-authored 23 scientific publications and 2 book chapters.
</blockquote>

Gas Chromatography Tips and Tricks

Find new best practices for gas management, and how to keep your system clean

Gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) have been in use for more than 60 years, consistently meeting the analytical performance demands of labs around the world.
With the ever-changing landscape of laboratory and analyst needs, instrument usability and space requirements are an acute focus and highly prioritized.
This webinar will highlight the maintenance operation critical to keeping your GC and GC-MS systems healthy. Along with these tips and tricks, this demonstration will also display how Shimadzu has reshaped the Brevis GC-2050 and GCMS-QP2050 to fit challenging laboratory requirements with simple operation, compact design, built-in analytical intelligence, and best-in-class performance.
By attending this presentation, you will learn:
<ul>
<li>maintenance tips for GC and GC-MS from experts</li>
<li>how built-in analytical intelligence can support high-throughput laboratory operations</li>
<li>how high-performing systems can optimize your workflow</li>
</ul>
<blockquote>
Presenter: Ryo Takechi (Global GC Product Manager, Shimadzu Corporation)
</blockquote>
<blockquote>
Ryo Takechi majored in chemical engineering from Doshisha University in Kyoto, Japan, and now has more than ten years of experience in gas chromatography and engineering of analytical instrumentation.
</blockquote>
<blockquote>
Presenter: Alan Owens (GC and GC-MS Product Manager, Shimadzu Scientific Instruments, Inc.)
</blockquote>
<blockquote>
Alan Owens is the GC and GC-MS Product Manager at Shimadzu Scientific Instruments. Alan joined Shimadzu in 2016 with a bachelor’s degree in biology and chemistry as a GC-MS product specialist before ascending to the role of product manager in 2021 for GC-MS and 2023 for GC. With over a decade of hands-on experience, Alan has established himself as a distinguished authority in gas chromatography and gas chromatography-mass spectrometry.
</blockquote>

Separation Science: Ensure the Optimal Performance of Your GC/GC-MS: Tips and Features of the Brevis GC-2050 and GCMS-QP2050

Ensure the Optimal Performance of Your GC/GC-MS: Tips and Features of the Brevis GC-2050 and GCMS-QP2050

This webinar will highlight the maintenance operation critical to keeping your GC and GC-MS systems healthy.

Tips and Features of the Brevis GC-2050 and GCMS-QP2050

Intelligent GCs simplify life inside - and outside - the lab.
Agilent&#39;s intelligent GCs are equipped with robust diagnostic and troubleshooting functions, aimed at minimizing operational downtime. These functionalities are not only accessible locally but can also be efficiently utilized remotely through the built-in browser interface on the Agilent 8860, 8890, and Intuvo 9000 GCs. During our session, we’ll demonstrate specific instances to illustrate how these GCs effectively identify issues and how remote access allows you to address them independent of your proximity to the system. 
When you enable remote operations, you enable faster issue resolution, optimization of your technical resources, and creation of a scalable model for managing instrument schedules and productivity. Why lose time moving your experts from system to system when they could assist technicians in nearby rooms, adjacent buildings, or even across continents from a single location? Join us to explore the extensive diagnostic capabilities of your Agilent GC and bring your queries for an in-depth Q&amp;A discussion.
<blockquote>
Presenter: Jamie Wetuski (Global GC Training Specialist, Agilent Technologies)
</blockquote>
<blockquote>
Jamie Wetuski is the Global GC Training Specialist on the Technical Marketing Team at Agilent Technologies, where she focuses on assisting customers with achieving their GC goals. She began her career at Agilent in the Gulf Coast as a Field Support Scientist servicing Agilent GC/GCMS systems. Jamie received a B.S.in Chemistry from Fort Lewis College in Durango, Colorado and an M.S. in Analytical Chemistry from Illinois Institute of Technology.
</blockquote>
<blockquote>
Presenter: Abbey Fausett (Applications Scientist, Gas Phase Separations Division, Agilent Technologies)
</blockquote>
<blockquote>
Abbey Fausett is an applications scientist within Agilent’s Gas Phase Separation Division. Her responsibilities include developing methods for emerging markets, proving existing methods on new systems, and creating material focused on new features within GC and GCMS systems. Before joining Agilent in 2011, she was an Agilent customer for 10+years, tasked with multi-technique method development, validation, and troubleshooting.
</blockquote>

Agilent: Diagnostics From Your Desk, Troubleshooting From Your Kitchen Table

Diagnostics From Your Desk, Troubleshooting From Your Kitchen Table

Join us to explore the extensive diagnostic capabilities of your Agilent GC and bring your queries for an in-depth Q&A discussion.

Agilent GC Diagnostics and Troubleshooting webinar

Selecting the best GC for you
<blockquote>
Presenter: John Wasson
</blockquote>
<blockquote>
John Wasson has over 40 years of experience in Gas Chromatography and Chemical Instrumentation. He is President of Wasson-ECE Instrumentation, Inc.
</blockquote>

Wasson-ECE Instrumentation: Selecting the Best GC

Selecting the Best GC

Webinar will cover the following topic: Selecting the best GC for you

Purge &amp; Trap technology is often used to achieve the legal detection limits of volatile and very volatile organic compounds in water samples. Especially in case of water intended for human consumption, the regulatory requirements are particularly stringent. When dealing with more complex matrices, headspace analysis offers a much cleaner approach compared to purging the sample. However, sensitivity could be limited without a suitable enrichment of the analytes before injection.
The technological developments in recent years on new headspace extraction/enrichment techniques, such as ITEX (In Tube Extraction), makes possible to achieve low detection limits for volatiles with a clean sampling approach, without purging. Different adsorbents can be used for ITEX depending on the analytical demand. Additionally, a suitable refocusing before transferring the sample into the chromatography column, provides narrow peaks, better signal-to-noise and enhanced sensitivity especially for very volatile organic compounds (VVOCs). This webinar gives an insight of the available technology along with various examples from a routine laboratory.
<h5>Who should attend:</h5>
<ul>
<li>Laboratory manager of environmental testing laboratories</li>
<li>Analysts who have to detect trace levels of VOCs and VVOCs in water</li>
<li>Analysts looking for a clean and sensitive sampling techniques for VOCs and VVOCs in water</li>
</ul>
<blockquote>
Presenter: Daniela Cavagnino (Product Marketing Manager, GC &amp; Autosampler, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Dr. Daniela Cavagnino received a Master Degree in Chemistry at the University of Milan, Italy. She started her career in gas chromatography at Thermo Fisher Scientific spending several years in the R&amp;D laboratories working on GC technology innovation and more than 15 years in product and marketing management roles promoting GC/GC-MS technology and applications.
</blockquote>
<blockquote>
Presenter: Petra Gerhards (Regional Marketing Manager EMEA GC &amp; GC-MS, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Petra Gerhards is a Regional Marketing Manager of GC and GC-MS at Thermo Fisher Scientific. She has more than 29 years of experience in the fields of GC-MS, SPE and LC-MS. Since joining the regional team, she has contributed to workflow solutions combining vials and closures with SPE solutions, GC-MS and LC-MS.
</blockquote>

ThermoFisher Scientific: Improvements for the analysis of very volatile organic compounds (VVOC) using static and dynamic headspace

Improvements for the analysis of very volatile organic compounds (VVOC) using static and dynamic headspace

Insight of the available technology for headspace extraction/enrichment techniques, such as ITEX, along with various examples from a routine laboratory.

Analysis of VVOC using static and dynamic headspace

In this session, discover how Wiley’s <a href="https://gcms.labrulez.com/products/1016">KnowItAll</a> saves hours of GC-MS manual analysis time by combining fast, flexible deconvolution with an integrated reference database search into a single, automated workflow to identify components.
In this session we will demonstrate through a series of live examples:
<ul>
<li><a href="https://gcms.labrulez.com/products/1016">KnowItAll’s</a> various <a href="https://gcms.labrulez.com/products/1020">methods for GC-MS analysis</a> and how they can impact your workflow. </li>
<li>How <a href="https://gcms.labrulez.com/products/1016">KnowItAll</a> is optimized for searching and review popular <a href="https://gcms.labrulez.com/products?category=249&amp;search=Wiley">GC-MS libraries</a>, such as the <a href="https://gcms.labrulez.com/products/886">Wiley Registry 2023</a>, <a href="https://gcms.labrulez.com/products/884">NIST</a>, <a href="https://gcms.labrulez.com/products/937">MMPW</a>, or <a href="https://gcms.labrulez.com/products/939">MS of Designer Drugs</a>.</li>
</ul>
This session is recommended for:
<ul>
<li>Scientists and chemists who use mass spectrometry or are interested in learning more about our capabilities. </li>
<li>Professors and students engaged in chemistry and mass spectrometry courses or lab work.</li>
</ul>
About KnowItAll:
KnowItAll combines all the tools and spectral databases you need for effective analysis into a single, easy-to-use interface to make your lab its most efficient. Compatible with over 130 instrument formats, it streamlines your entire workflow regardless of how many techniques and instruments you use. Learn more at <a href="sciencesolutions.wiley.com">sciencesolutions.wiley.com</a>
<blockquote>
Presenter: Dr. Leanna Ergin
</blockquote>
<blockquote>
Dr. Leanna Ergin is an Assistant Editor for Wiley Science Solutions, for which she helps create tools for spectroscopy, structural, and scientific standard reference data and helps create innovative software applications. Leanna completed her PhD in Clinical-Bioanalytical Chemistry from Cleveland State University, where she developed a protocol for processing hyperspectral image data that distinguishes the spectra, removes degeneracies caused by symmetry, and is generalized to work with any number of wavelength dimensions and spectra. The results are mapped to the full RGB colorspace of modern computer displays. Leanna joined Wiley in 2022.
</blockquote>

Wiley: Introduction to KnowItAll for Mass Spectrometry

Introduction to KnowItAll for Mass Spectrometry

Discover how Wiley’s KnowItAll saves hours of GC-MS manual analysis time

Explore advanced analytical techniques and methodologies for assessing hydrocarbon contamination in water sources, increase sample throughput and gain valuable insights into environmental monitoring. Hydrocarbons, originating from various sources such as industrial discharges, urban runoff, or natural processes, can adversely impact aquatic ecosystems. Understanding the Hydrocarbon Index is essential for safeguarding water resources, protecting ecosystems, and promoting public health and environmental sustainability.
Public environmental service providers and contract testing laboratories could greatly increase sample throughput of water samples for the analysis of total hydrocarbon index according to the method EN ISO 9377-2, thanks to an automated workflow for liquid-liquid extraction, clean-up and on-line large volume injection into the GC, through the robotic Thermo Scientific TriPlus RSH SMART Autosampler. The system is fully controlled by Thermo Scientific Chromeleon Chromatography Data System (CDS) Software. Thanks to the Intelligent Sequence and the eWorkflow functionalities, it offers a complete automated management of the samples, automated reporting and transfer to LIMS, enabling 24/7 operations with significant labor and cost saving. 
What you will learn:
<ul>
<li>How to optimize mineral oil analysis in water samples</li>
<li>How to stay compliant with ISO 9377-2 guideline</li>
<li>How to face increasing sample demand through automation</li>
</ul>
Who should attend:
<ul>
<li>Laboratory managers of environmental testing laboratories</li>
<li>Laboratory managers at water service providers</li>
<li>Analysts looking for increasing throughput for mineral oil analysis in water samples</li>
</ul>
If you have questions for our experts, please submit them during registrations or send them anytime in advance via email to analyze.eu@thermofisher.com. Live questions will be handled during the webinar in our Q&amp;A chat.
Short notice: Can&#39;t attend the live broadcast? No problem! Register anyway and you will automatically receive the link to the webinar recording.
<blockquote>
Presenter: Petra Gerhards (Regional Marketing Manager, GCMS and TEA, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Her background is over 34 years of experience in the field of GCMS, SPE and LCMS. Since joining the EMEA Regional Marketing Team for CCS in 2016, she has been involved in a lot of workflow solutions combining Vials and Closures with SPE solutions, GCMS and LCMS.
</blockquote>
<blockquote>
Presenter: Daniela Cavagnino (Product Marketing Manager, GC and Sampling Solutions, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Dr. Daniela Cavagnino received her Masters Degree in Chemistry at the University of Milan, Italy. She started her career in gas chromatography at Thermo Fisher Scientific spending several years in the R&amp;D laboratories working on GC technology innovation. Then, she conveyed her technical background into product management and marketing management roles with more than 15 years experience in promoting GC/GCMS technology and applications in several different market segments.
</blockquote>

ThermoFisher Scientific: Unlocking water quality insights: Hydrocarbon index analysis for environmental monitoring

Unlocking water quality insights: Hydrocarbon index analysis for environmental monitoring

Explore advanced analytical techniques and methodologies for assessing hydrocarbon contamination in water sources.

Water quality: Hydrocarbon index analysis

Join us for an insightful webinar delving into customization of GC for analysis of gas samples using valve configurations.
By participating in this webinar, you will have the opportunity to engage with Agilent expert, exchange knowledge, and learn:
<ol>
<li>Basics of valve functioning.
</li>
<li>Usage of typical columns for gas analysis.
</li>
<li>Application of gas purity analysis.
</li>
<li>Examples of few analyzers’ solutions (such as TOGA, RGA and NGA).
</li>
<li>Common tips for using the valve configurations efficiently.
</li>
</ol>
<blockquote>
Presenter: Mr. Praveen Arya (Application Engineer - GC/MS, Agilent Technologies)
</blockquote>
<blockquote>
Praveen Arya, Application Engineer at Agilent technologies, has a commitment and appreciation for Gas-phase residue applications. In 2005, Mr. Praveen Arya completed his M.Sc. in Food Technology . After post-graduation, he served as a Senior Analyst at SGS, Gurgaon- a commercial testing laboratory for 6 years and developed expertise in Residue analysis using sophisticated chromatographic instruments such as LCMS and GCMS. After that, in 2011, He joined Agilent Technologies as an Application Engineer where he supported country-wide GCMS customers for resolving application issues and method development. He has more than 18 years of experience in residue analysis in food and environmental samples using various high end chromatographic and spectrometric techniques (GC, GCMS, GCMS/MS, TDS, Headspace, Purge &amp; trap etc.). His area of specialization includes new analytical method development and validation as per national and international guidelines.
</blockquote>

Online GC for Gas Analysis

Customization of GC for analysis of gas samples using valve configurations.

Residual solvents are substances that remain in a drug product after the manufacturing process, originating from materials used or reactions occurring during production. Residual solvents pose potential health risks, so regulatory bodies like the ICH and the USP has set limits and testing requirements to ensure product safety.
Register now and attend this webinar to learn:
<ol>
<li>Latest trends &amp; applications in residual solvent analysis
</li>
<li>Systematic approach in conducting residual solvent analysis
</li>
<li>Analytical workflow &amp; system solutions to get accurate &amp; reproducible results
</li>
<li>Agilent&#39;s latest residual solvent analysis workflow
</li>
<li>Tips &amp; tricks for getting best outcomes in your day-to-day analysis
</li>
</ol>
<h4>Other webcasts from the series</h4>
<h5>Advanced LC/HR-MS Based Workflow for Extractable and Leachable Analysis</h5>
<ul>
<li>Thursday, 04 July 2024, 15:00 IST</li>
</ul>
<h5>Advanced GC/MS | GC/HR-MS Based Workflow for Extractable and Leachable Analysis</h5>
<ul>
<li>Thursday, 08 August 2024, 15:00 IST</li>
</ul>
<h5>Demystifying USP &amp; ICHQ3D Guidelines for Elemental Impurities</h5>
<ul>
<li>Thursday, 05 September 2024, 15:00 IST</li>
</ul>
*Register for all the webinars and get complementary access to The experts guide to Pharmaceutical Impurity Analysis e-book.
<blockquote>
Presenter: Dr. Kuldeep Sharma (Sales Development Manager - Pharma, Agilent Technologies)
</blockquote>
<blockquote>
Kuldeep Sharma has over 19 years of experience in area/s of Bioanalytical research, Drug metabolism &amp; pharmacokinetics and Pharma regulatory compliance. He has accomplished PhD in Biotechnology. His professional journey covers over 12 years in Analytical research (associated with R&amp;D’s of Zydus Cadila, Lambda, Pliva and Jubilant Biosys) and last 7 years in analytical instruments sales, marketing &amp; business development. With over 21 research articles published in international Journals, He presents convention of continues learning.
</blockquote>
<blockquote>
Presenter: Mr. Praveen Arya (Application Engineer - GC/MS, Agilent Technologies)
</blockquote>
<blockquote>
Praveen Arya, Application Engineer at Agilent technologies, has a commitment and appreciation for Gas-phase residue applications. In 2005, Mr. Praveen Arya completed his M.Sc. in Food Technology . After post-graduation, he served as a Senior Analyst at SGS, Gurgaon- a commercial testing laboratory for 6 years and developed expertise in Residue analysis using sophisticated chromatographic instruments such as LCMS and GCMS. After that, in 2011, He joined Agilent Technologies as an Application Engineer where he supported country-wide GCMS customers for resolving application issues and method development. He has more than 18 years of experience in residue analysis in food and environmental samples using various high end chromatographic and spectrometric techniques (GC, GCMS, GCMS/MS, TDS, Headspace, Purge &amp; trap etc.). His area of specialization includes new analytical method development and validation as per national and international guidelines.
</blockquote>
<blockquote>
Presenter: Mr. Ankush Sharma (Regional Marketing Program Manager- APAC (Pharma &amp; Biopharma), Agilent Technologies)
</blockquote>
<blockquote>
Ankush Sharma is a seasoned professional with over 12 years of extensive experience in sales and marketing across the pharmaceutical and biopharmaceutical sectors. His professional journey commenced with a strong educational foundation, earning a Master&#39;s degree in Biotechnology. Building upon this knowledge, he furthered his academic pursuits by obtaining a Master&#39;s in Business Administration with a specialization in Sales and Marketing, demonstrating his commitment to blending scientific understanding with strategic business acumen. For the past five years, he has been an integral part of Agilent, serving as the Regional Marketing Program Manager for the India and now Asia-Pacific (APAC) region for Pharma and Biopharma Markets.
</blockquote>

Agilent: USP 467 Residual Solvent: Application Updates Tips & Tricks

USP 467 Residual Solvent: Application Updates Tips & Tricks

Learn latest trends & applications in residual solvent analysis, Agilent's latest residual solvent analysis workflow, tips & tricks for getting best outcomes.

Join us for an insightful session where scientists and IT professionals from AstraZeneca come together to explore the complexities of managing analytical data within a purification lab setting. In this session, Carolina Sanchez, Senior Scientist, and Katie Proctor, Senior Scientist, will discuss the challenges of manually processing and reviewing large volumes of analytical data, and explain how automation software solutions are boosting efficiency and benefiting them in their day-to-day work. Following that, Dr. Christoph Bauer, Associate Principal Scientist, will discuss the IT architecture and integration aspects of the solution implementation.A lab with significant analytical capacity entails managing a large number of instruments and extensive analytical data on a daily basis. Within our purification labs, analytical screening data generated for compounds submitted for purification, as well as data from instrument suitability testing, was traditionally reviewed manually by an analyst to determine the most appropriate method for purification. However, this changed with the implementation of the automation solution from Mnova. The solution includes the Chrom SST brick, which monitors the performance of our instruments, and Chrom Best Method, which automatically processes the screening data and identifies the best conditions for purification, thereby freeing up analyst time.In this webinar, we will explain how these solutions fit into our day-to-day work and the benefits they have brought us. We will also discuss the IT architecture and integration aspects, the server-based processing logic, as well as the content and formats of the output.<blockquote>Presenter: Carolina Sanchez (Senior Scientist, AstraZeneca)Carolina is a chemical engineer and biotechnologist with a keen interest in data science. Since 2015, she’s been deeply involved in chromatography, getting better at developing analytical techniques for various uses. For the past four years, she’s been at AstraZeneca, working as a separation scientist where she focuses on preparative chromatography of small molecules, using both liquid and supercritical fluid chromatography methods.Presenter: Christoph Bauer (Associate Principal Scientist, AstraZeneca)Christoph holds a PhD in theoretical Chemistry and has transitioned to the field of chemoinformatics and modeling where he applies quantum chemistry, statistical analysis, and machine learning methods to chemical data within the pharmaceutical science domain. Over the past four years, he has been working in the Pharm Sci Data Science &amp; Modelling group at AstraZeneca, developing cheminformatics and computational solutions aimed at streamlining chemistry workflows.Presenter: Katie Proctor (Senior Research Scientist, AstraZeneca)Katie is a Senior Research Scientist in the Analytical and Purification group at AstraZeneca Cambridge since 2018. She has a keen interest in data science and has a focus on developing software solutions to automate system suitability assessments and analytical to purification method selection. In the lab, Katie focuses on achiral SFC and RP purification of small molecules.</blockquote>

Mestrelab Research: Automation in a purification lab at AstraZeneca

Automation in a purification lab at AstraZeneca

Session where scientists and IT professionals from AstraZeneca explore the complexities of managing analytical data within a purification lab setting.

GCMS webinars focusing on GC - page 11