Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 16th March 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you posters by Agilent Technologies / ASMS and MDCW / William &amp; Mary, application note by Shimadzu and other document by Thermo Fisher Scientific!<h3>1. Agilent Technologies / ASMS: Analysis of Extractables and Leachables in Catheters Using Accurate Mass Libraries and High-Resolution GC/MS and LC/MS</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ps_7250_revident_extractables_leachables_asms_2025_tp_317_en_agilent_e6d3b2e923.pdf">Full PDF for download</a></li></ul>Materials used in the production of medical devices contain substances that have the potential to leach from the devices. Extractables and leachables (E&amp;L) represent a range of structurally diverse compounds including antioxidants, UV absorbers, dyes, catalysts, plasticizers and polymer degradation products. Therefore, both liquid and gas chromatography techniques coupled with mass spectrometry detectors (LC/MS and GC/MS) are utilized to achieve a comprehensive chemical characterization. Application-specific accurate mass libraries combined with an efficient screening workflow, helps to increase confidence in compound identification that saves time on reviewing data while focused on E/L relevant compounds. In this study, we analyzed catheters extracts using high-resolution MS and performed data analysis using accurate mass libraries.<h4>Experimental</h4>Catheters from three suppliers were used in this study. Catheter A was made from PVC, and did not include DEHP, DINP, BPA or natural rubber latex. Catheter B was made with natural rubber latex base and silicone elastomer coating, and there was no claim to be phthalate or BPA free. Catheter C was a silicone-coated latex catheter made with natural rubber latex base and no DEHP or BPA. E&amp;L standards were obtained from AChemTek. Catheters were extracted with ethanol:water 1:1 solvent at 37 ˚C for 24 and 48 hours as well as 7 days and analyzed using GC/Q-TOF and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=Revident+LC%2FQ-TOF">LC/Q-TOF systems</a>. The GC/MS analysis was performed using the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890+GC">8890 GC</a> coupled to the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7250+GC%2FQ-TOF">7250 Q-TOF</a> and the new Agilent low bleed DB-5Q column.<h4>Results and Discussion</h4><h5>Accurate Mass E&amp;L Library for GC/Q-TOF</h5>To create a new Agilent accurate mass E&amp;L Personal Compound Database Library (PCDL) for GC/Q-TOF, over 400 spectra have been collected for E&amp;L compounds. All accurate mass fragment ions in each spectrum have been annotated with formulas based on accurate mass information and isotope ratios (Figure 3). The fragment formula annotations were then verified and converted to the theoretical m/z.<h4>Conclusions</h4><ul><li>A combined workflow for the analysis of extractables and leachables by high-resolution GC/MS and LC/MS was developed using catheter extracts.</li><li>Both GC/MS and LC/MS techniques were necessary to cover a comprehensive list of E&amp;L compounds. Although several E&amp;L compounds were detected by both GC/MS and LC/MS, in most cases hydrocarbons, most plasticizers, and some antioxidants were more amenable to GC/MS.</li></ul><h3>2. MDCW / William &amp; Mary: A sustainable approach to nontargeted analysis using hydrogen as a carrier gas for GC×GC</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/P_13_Fisher_2c50f2c420.pdf">Full PDF for download</a></li></ul>Comprehensive two-dimensional gas chromatography (GC×GC) is a separation technique used to separate complex mixtures based on two different retention mechanisms, usually polarity and volatility. A nontargeted approach is commonly used for a separation technique such as GC×GC. This type of approach means that instead of looking for one or two specific components and disregarding the rest of the sample, the whole sample can be viewed exhaustively. This approach is more applicable for forensic cases especially, where the identity or composition of the sample is unknown. It is also a more sustainable approach because only one run is needed to have the full characterization of a sample instead of needing to run a sample multiple times with a different target analyte each time.<h4>EXPERIMENTAL</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37">LECO’s Pegasus BT4D</a> instrument was used for this project.</li></ul><h4>RESULTS</h4>AGREEprep Comparisons: The overall scores for the two methods were 0.44 and 0.52 for helium and hydrogen, respectively. This means that the hydrogen method is more sustainable than the helium method. The criteria breakdown in Figure 6 shows the 10 different criteria used to score the methods, including sample throughput, sample preparation steps, and sustainable material usage, namely carrier gas choice.<h4>CONCLUSIONS</h4>The Restek EZGZ Method Translator can be used to provide three possible hydrogen methods for any given helium method. After inputting the values of a helium method, the respective hydrogen values are given for three possible methods, each prioritizing something different: translate, efficiency, and speed. The translate method was chosen as the best choice.&nbsp;The hydrogen method achieved a higher score on the AGREEprep metric, meaning that this method is more sustainable that the helium method. This better score is solely due to the carrier gas change – everything else in the methods stayed constant.&nbsp;Hydrogen as a carrier gas allows for higher sample throughput and faster run times. It can also be a renewable resource, made through the electrolysis of water in a laboratory using a generator.&nbsp;A nontargeted approach is inherently greener than a targeted approach because instead of re-running a sample multiple times to analyze a different component each time, the whole picture was captured from the beginning and can be looked at through a different lens to analyze a new component.<h3>3. Shimadzu: Analysis of PFAS in Textiles Based on EN 17681-1 and EN 17681-2</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01108_en_e04fe25939.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>Combining LCMS and GCMS enables the determination of PFAS below threshold limits in textiles.&nbsp;</li><li>Spike recovery test shows good percentage recoveries of all compounds (70–130 %) that are at or below the EU POPs threshold limit (25 ppb).</li><li>LabSolutions software offers integrated control over GCMS and LCMS for more efficient testing and data analysis.</li></ul>Per- and polyfluoroalkyl substances (PFAS) are used in a wide range of applications because of their useful properties, such as heat resistance and water repellency. However, PFAS are also extremely stable substances that resist degradation and accumulate in the environment, which has led to concerns about their effects on humans. Since eliminating sources of PFAS is essential to prevent them from accumulating in the environment and in living organisms, many countries are passing laws that restrict the production, distribution, and use of PFAS in products. For example, the EU POPs Regulation sets a permitted threshold of up to 0.025 mg/kg (25 ppb) for certain PFAS (including PFOA, PFOS, and PFHxS) in substances, mixtures, and products1).&nbsp;EN 17681 is a European standard that describes methods for determining PFAS in textiles. The EN 17681 standard is divided into two parts according to the target compounds and methods. EN 17681-1 describes an LC/MS/MS method that targets ionic PFAS, and EN 17681-2 describes a GC/MS(/MS) method that targets certain semi-volatile and volatile neutral PFAS. A 2025 revision of EN 17681-1 changed the sample preparation method for more efficient PFAS extraction2),3).&nbsp;This Application News describes the analysis of the target compounds shown in Table 1 based on the EN 17681-1 and EN 17681-2 standards, using both LC/MS/MS and GC/MS/MS.<h4>&nbsp;EN 17681-1 (LC/MS/MS) Analysis Conditions</h4>Analysis was performed using the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=LCMS-8050RX">LCMS-8050RX triple quadrupole mass spectrometer</a> (Fig. 1, left). The analysis conditions used are shown in Table 3. Analyzing PFAS necessitates caution because PFAS can leach from the analytical system, the mobile phase or other sources. PFAS contamination from the system was minimized by attaching a delay column between the mixer and autosampler. The mobile phase was also prepared using PFAS grade reagents.<h4>EN 17681-2 (GC/MS(/MS)) Analysis Conditions</h4>Analysis was performed using a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-TQ8050+NX">GCMS-TQ8050 NX triple quadrupole mass spectrometer</a> (Fig. 1, right) that was equipped with a boosted efficiency ion source (BEIS). The BEIS optimizes the electron beam focus for maximum ionization efficiency, enabling reliable analysis of PFAS at very low levels. The analysis conditions used are shown in Table 4.<h4>Results from Analysis of Ski Wear</h4>Old ski clothing was used as a sample. The results obtained from analyzing this sample by the EN 17681-1 (LC/MS/MS) method are shown in Fig. 11. To investigate the effect of the EN 17681- 1:2025 update, analysis was performed using both the preupdate (EN 17681-1:2022) and post-update (EN 17681-1:2025) sample preparation methods. The alkaline hydrolysis treatment used by the EN 17681-1:2025 method dramatically increased the amounts of NMeFOSE, 6:2 FTOH, 8:2 FTOH, and 10:2 FTOH that were detected, and these compounds were detected at levels above the upper limit of their respective calibration curve ranges. This shows that PFAS extraction is improved by using the updated EN 17681-1:2025 sample preparation method. Of the 33 compounds targeted by the LC/MS/MS method, 20 were detected in the sample.&nbsp;Analyzing the sample by GC/MS/MS using the EN 17681-2 method detected 8 out of the 12 compounds targeted by the EN 17681-2 method. Of these, 8:2 FTOH and 10:2 FTOH were detected at levels above the upper limit of their respective calibration curve ranges (Fig. 12).<h4>Conclusion&nbsp;</h4>The analysis of PFAS in textiles was performed according to EN 17681-1 and EN 17681-2 standards, utilizing the LCMS-8050RX and GCMS-TQ8050 NX systems. By combining LC/MS/MS analysis and GC/MS analysis, all target compounds were successfully measured at levels of 25 ppb or less. Spike recovery test at the EU POPs threshold limit (25 ppb) also demonstrated good percentage recovery (70–130 %) for all compounds. Results also showed that PFAS extraction was improved by using the EN 17681-1:2025 sample preparation method, which was updated in 2025.<h3>4. Thermo Fisher Scientific: Fast on-line monitoring of flare gases</h3><ul><li>Other document</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/fast_on_line_monitoring_of_flare_gases_wp1635_27fa9188ff.pdf">Full PDF for download</a></li></ul><h4>Measurement of flare gas streams by process mass spectrometry</h4>Process mass spectrometry (MS) is particularly suited to the measurement of flare gas streams because it offers accurate, fast, multicomponent analysis. Table 1 shows an example of a flare gas stream containing hydrogen, nitrogen and hydrocarbons up to C6. Analysis of these eleven components will typically be performed in just 20 seconds, allowing one mass spectrometer to monitor more than one flare, depending on the distances involved. Alternatively, one MS can be used to measure process streams and flare streams, even though the composition and concentrations may be very different.<h4>Advantages of magnetic sector MS&nbsp;</h4>Thermo Fisher Scientific manufactures both quadrupole and magnetic sector mass spectrometers. Over thirty years of industrial experience have shown the magnetic sector based analyzer offers the best performance for industrial online gas analysis. Thermo Scientific™ Prima PRO process mass spectrometers (Figure 1) offer ideal capabilities for industrial gas analysis.&nbsp;Key advantages of magnetic sector analyzers include improved precision, accuracy, long intervals between calibrations and resistance to contamination. Typically, analytical precision is between 2 and 10 times better than a quadrupole analyzer, depending on the gases analyzed and complexity of the mixture.&nbsp;Neutral gas atoms and molecules are first converted into positively charged ions in the Prima PRO MS ion source. This is an enclosed type for high sensitivity, minimum background interference and maximum contamination resistance. It is a high-energy (1000 eV) analyzer that offers extremely rugged performance in the presence of gases and vapors that have the potential for contaminating the internal vacuum components. Prima PRO MS has a proven track record of monitoring high percent level concentrations of organic compounds without experiencing drift or contamination.Ions are then accelerated through a flight tube, where they are separated by their mass to charge ratios in a magnetic field of variable strength. Since the magnetic sector mass spectrometer produces a focused ion beam at the detector, the peak shape obtained is ‘flat-topped’ and uniform response is observed over a finite mass width. As the height of the peak is directly proportional to the number of ions striking the detector it is also directly proportional to the concentration of the component being measured. As long as the measurement is taken anywhere on the peak’s flat top, high precision analysis will be observed.The Prima PRO MS’ ability to measure over a wide dynamic range is critically important if the varying composition levels in flare gas are to be measured accurately. The Prima PRO MS has been independently evaluated by EffecTech UK, an independent specialist company providing accredited calibration and testing services to the energy and power industries for gas quality, flow and total energy metering. It is accredited to internationally recognized ISO/IEC 17025:2005 standards; this specifies the general requirements for the competence to carry out tests and/ or calibrations, including sampling.<h4>Summary&nbsp;</h4>Magnetic sector MS, as evidenced by the Prima PRO process MS performance, provides fast, accurate on-line analysis of flare gas composition. The inherent power of magnetic sector mass spectrometry, combined with the flexibility of GasWorks software, enables one Prima PRO MS to monitor not only flare gas streams, but also multiple process streams. Root cause fault analysis is therefore greatly facilitated, by comparing the detailed composition data from the flare gas stream with that of the various process streams. As well as complete compositional analysis, Prima PRO MS provides accurate fuel gas properties, including LHV, HHV, density, specific gravity, Wobbe Index, stoichiometric air requirement and CARI. This ensures waste gases are burnt to complete combustion and unburned pollutants are not emitted from the flare.

News from LabRulezGCMS Library - Week 12, 2026

Wiley, a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation and learning, today announced the 2026 release of Mass Spectra of Designer Drugs, the essential GC‑MS spectral database used by forensic laboratories worldwide for the rapid identification of illicit substances.As the landscape of novel psychoactive substances (NPS) continues to evolve—with growing numbers of synthetic cannabinoids, metabolites, fentanyl analogs, pharmaceutical drugs and metabolites, derivatives, and other emerging compounds—laboratories rely on continuously updated reference data to keep pace.The latest release includes updates to ensure comprehensive and up‑to‑date support for forensic, toxicology, and drug surveillance workflows:<ul><li>Addition of over 700 new mass spectra</li><li>More than 400 new unique compounds, spanning key NPS categories such as fentanyl variants, xylazine, synthetic opioids including nitazene opioids, and cannabinoids</li><li>37,075 total mass spectra and 27,900 unique chemical entities now represented in the database.</li></ul>“The 2026 release strengthens Wiley’s position as the leading source of trusted spectral intelligence, giving laboratories the high-quality data they need to quickly and confidently identify emerging designer drugs with confidence. These enhancements directly support forensic and public health efforts as new harmful substances continue to appear.” said Graeme Whitley, Senior Director, Data Science Solutions at Wiley.<h4>Purpose‑built for forensic and analytical laboratories</h4>Engineered for the unique demands of forensic and toxicology labs, the Mass Spectra of Designer Drugs database works with most major mass-spectrometry systems and is also available as a KnowItAll database subscription. When paired with Wiley’s KnowItAll software, the database unlocks a powerful suite of advanced forensic tools, including drug classification models and Wiley’s patented MS Adaptive Search, that accelerate the identification and interpretation of both known and emerging compounds. These capabilities empower analysts to detect even novel or unusual substances with greater speed, clarity, and certainty, reinforcing the database’s role as an indispensable resource for laboratories working at the front lines of drug detection.<h5>About <a target="_blank" rel="noopener noreferrer" href="https://www.wiley.com/en-ie/">Wiley</a></h5>Wiley (NYSE: WLY) is a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation, and learning. With more than 200 years at the center of the scholarly ecosystem, Wiley combines trusted publishing heritage with AI-powered platforms to transform how knowledge is discovered, accessed, and applied. From individual researchers and students to Fortune 500 R&amp;D teams, Wiley enables the transformation of scientific breakthroughs into real-world impact. From knowledge to impact—Wiley is redefining what's possible in science and learning.&nbsp;

New release Wiley's Mass Spectra of Designer Drugs 2026 expands coverage of emerging novel psychoactive substances

The leaflet outlines the role and handling of analytical equipment and systems in the process of a laboratory dealing with the analysis of chemical elements and molecules. It is an introduction to topics being considered by the Eurachem Analytical Equipment and Systems Qualification Working Group.&nbsp;Various steps are required to draw a conclusion concerning the object being examined (sampling target), see Fig. 1. The core part, the analytical measurement, is based on an analytical principle. The measurement is based on a physical or chemical interaction, e.g. between light of a certain wavelength and the sample, which leads to a displayed measured value. This measurement is carried out using analytical equipment. This equipment must be fit for its intended use. Complex analytical equipment with extensive data processing is referred to as a system. Analytical equipment is used to perform the analytical method. The method must be validated to demonstrate that it is fit for purpose.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Fig_1_Analytical_principle_method_and_procedure_1_b751d25236.jpg" alt="Eurachem: Fig. 1 Analytical principle, method and procedure [1]" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Fig_1_Analytical_principle_method_and_procedure_1_b751d25236.jpg 245w," sizes="100vw" width="841" height="439"><h4>The pyramid of quality&nbsp;</h4>The pyramid of quality (Fig. 2) covers the analytical method. In order to produce a reproducible, reportable result that is suitable for the intended purpose, the equipment (system) (1st level) and analytical method (2nd level) must be well defined and under control, qualified or validated, respectively.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Fig_2_Pyramid_of_quality_979312ac6b.jpg" alt="Eurachem: Fig. 2 Pyramid of quality" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Fig_2_Pyramid_of_quality_979312ac6b.jpg 163w," sizes="100vw" width="708" height="677">The equipment must have similar performance when carrying out the analyses as when developing and validating the method. Particularly in the case of methods based on libraries or training datasets, the long-term stability of the equipment must be ensured. In the case of transfer of the method to other equipment, both sets of equipment must have similar performance.&nbsp;The performance of the equipment and the behaviour of the method are monitored by quality control measures. This is the purpose of the internal or short term (3rd level) and inter-laboratory or long term (4th level) quality assurance. When selecting the quality assurance elements, the findings from levels 1 and 2 are taken into account.&nbsp;<h4>Is "calibration" sufficient?&nbsp;</h4>All relevant quality assurance systems, e.g. those meeting the requirements of ISO/IEC 17025 [2] and related standards, require equipment and systems to be traceably calibrated. But is that enough to prove the fitness for the intended use of the analytical equipment?&nbsp;According to the definition in VIM [3] calibration is the operation that, under specified conditions, establishes a relation between the quantity values with measurement uncertainties provided by measurement standards and corresponding indications with associated measurement uncertainties. It is implicitly assumed that the influencing quantities (e.g. ambient conditions, temperature, flow rates, intensities of signal sources, etc.) are constant and do not exhibit any short or long-term fluctuations or drifts. This assumes that no changes occur due to influencing quantities.&nbsp;Nevertheless this is not the case in everyday analytical work. The influence of fluctuations or changes in the influencing quantities is evaluated through robustness investigations during method development and validation. The magnitude of the fluctuations or deviations of the equipment is specified and verified during equipment qualification.&nbsp;<h4>The Fitness for Intended Use&nbsp;</h4>The life cycle (Fig. 3) of new equipment to be purchased by the laboratory begins with the definition of the requirements and the intended use of the equipment.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Fig_3_Equipment_or_system_lifecycle_2919ea802d.jpg" alt="Eurachem: Fig. 3 Equipment or system lifecycle" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Fig_3_Equipment_or_system_lifecycle_2919ea802d.jpg 186w," sizes="100vw" width="887" height="742">The User Requirement Specifications (URS) define the selection criteria and the operational ranges of the equipment parameters (influence variables), e.g. flows, temperatures, analysis volumes, etc. Considerations to support data integrity and traceability are also included in the URS. For more complex systems, the interfaces and compatibility of the components are essential.&nbsp;All considerations made in this phase have an impact on the entire life cycle, i.e. right through to decommissioning. The stability and variability of the influence variables are monitored over the entire service life.&nbsp;In most cases, data and metadata should remain accessible and analysable beyond the end of the equipment's life. The laboratory must use its resources as sparingly and sustainably as possible. This includes the expected service life and the costs incurred. Data integrity considerations (ALCOA+ = Attributable, Legible, Contemporaneous, Original, Accurate, + Complete, Consistent, Enduring, Available) play a role during operation and at the end of life. These include paper records and electronic records.&nbsp;In the pharmaceutical industry, qualification of equipment and thus ensuring that analytical equipment and systems are suitable for the intended use, is mandatory, and the respective processes are often clearly defined. Specifications are also comprehensively defined for various equipment classes.&nbsp;The ISO standards, in particular ISO 9001 [4], ISO 10012 [5], ISO/IEC 17025 [2], ISO 17034 [6] or ISO/IEC 17043 [7], cover a very large area and a wide range of sectors. For specific sectors, an interpretation of the standards is required. Eurachem guides cover requirements for analytical chemistry and related disciplines. The Analytical Equipment and Systems Qualification Working Group is therefore developing guidance on establishing the fitness for intended use of analytical equipment and systems aimed at these disciplines.

Fitness for the intended use of analytical equipment and systems

Article

Product

Application

Science and research

Poster

Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

Eurachem

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

For over 200 years we have been helping people and organizations develop the skills and knowledge they need to succeed.
We develop digital education, learning, assessment, and certification solutions to help universities, businesses, and individuals move between education and employment and achieve their ambitions.

Wiley

Separation Science

Metrohm

The Analytical Scientist

Agilent Technologies

AZoM

Restek Corporation

SelectScience

Shimadzu Corporation

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Following up from our very successful previous sessions, we are delighted to offer another panel discussion in the ever-popular “Ask the Agilent Experts” series.Have you ever had a question about your GC/GCMS analysis and thought, “I have no idea what to do,” or that since the question seemed so simple, everyone must already know the answer, and “Am I the only one who doesn’t know what to do?” We can assure you that you are not alone.If you have a question, we can guarantee that you are not the first...nor the last person to ask the question. Sometimes the simplest of questions can have the most complex answers. A question about how to improve your overall data quality can lead to a discussion about what types of columns should be used with a mass spec and why. A question about sensitivity can lead to a conversation about solvent focusing and maybe how to determine when to replace your EM horn. Even questions about when to tune or what type of tune to use will lead to a bigger conversation to determine what is best for that specific analysis. There is no such thing as an easy answer because the answer always “depends” on many different factors.We will discuss some of the most frequently asked questions about GC and GCMS that we have received. Many seem like simple questions, but have anything but simple answers. We'll also address new questions that we hope you will submit to us in advance to be answered by experts from Agilent, as well as from the field.<h5>By attending this discussion, you will learn:</h5><ul><li>How there are many factors impacting the sensitivity of the mass spectrometer, from solvent focusing at injection, to performing the correct type of tune, to the age of the EM horn, and how they all impact the sensitivity of the analytical method.</li><li>Why some consumables are more preferred for use with mass spectrometers, and listen to Agilent scientists discuss the complexities of the most frequently asked questions they receive.</li><li>Why column installation depth into the ion source is important, and what can happen if it is too short or too long.</li></ul><blockquote>Presenter: Vanessa Abercrombie (MFS, GC Applications Chemist, Agilent Technologies)Vanessa Abercrombie is a GC applications chemist at Agilent Technologies in Folsom, California, USA. Vanessa has a broad background in GC and GC/MS, including experience as an instrument chemist at Bode Technology in Virginia working under contract to the FBI’s Laboratory Division. Prior to that, Vanessa worked for ETS Labs in St. Helena, California, as an analytical chemist, where she researched and developed quantitative separations by GC/MS and UHPLC for beer, wine, and spirits. She holds a Masters of Forensic Science from The George Washington University and a Bachelor of Arts in Chemistry from Sonoma State University.Presenter:&nbsp;Samuel Haddad (Ph.D., Application Development Chemist, Agilent Technologies)Samuel Haddad is a GC Application Development Chemist at Agilent Technologies in Wilmington, Delaware. &nbsp;Samuel specializes in GC and GC/MS applications of trace analysis in environmental and heavy matrix samples. &nbsp;His specialty includes sample preparation techniques to separate analytes from matrix components and extraction from a wide variety of matrix including water, fish, aquatic life, soil, and complex fluids. &nbsp;Samuel holds a Ph.D. in Environmental Science from Baylor University and a B.S in Biology from Southern Illinois University Edwardsville. &nbsp; &nbsp;&nbsp; ModeratorPresenter:&nbsp;Diane Turner (Director &amp; Senior Consultant, Anthias Consulting Ltd)A Warwick University graduate, Diane completed her Master's in analytical chemistry and started her career in environmental chemistry, later gaining significant experience as an applications chemist. Diane’s area of research through her PhD studies at The Open University was disease diagnosis. She has developed methods and given support and training for companies in most industries around the world for more than 20 years. Diane holds voluntary roles with The Royal Society of Chemistry and other scientific organizations.</blockquote></div></div></div>

SeparationScience: Ask the Agilent Experts Series – Part 7: The Mass Spec Edition

Ask the Agilent Experts Series – Part 7: The Mass Spec Edition

GC and GC/MS scientists discuss and answer more of your most frequently asked questions.

Agilent Experts Series – Part 7: The Mass Spec Edition

<div><div id="inner_content_body_text" data-content-id="394785">Ensuring refined fuels and lubricants stay on spec is critical— and direct in-line measurement provides the confidence needed to maintain control throughout production. This webinar explores how a Process Raman Analyzer enables true direct in-line measurement of refined fuels and related products, including diesel, gasoline, jet fuel, and lubricants.We’ll share real-world examples of monitoring essential properties such as API gravity, RON, RVP, cetane, and flash point—all aligned with ASTM methods. Unlike other technologies, Process Raman requires no sample conditioning system and eliminates consumables or carrier gases, reducing complexity and costs while delivering continuous, non-destructive analysis.With its small footprint and hazardous-location rating, Process Raman integrates seamlessly into production environments—providing operators with peace of mind through reliable, uninterrupted monitoring and immediate detection of deviations. The result: tighter process control, consistent product quality, and lower operating costs.<h5>Process Raman Enables:</h5><ul><li>Immediate detection of deviations for faster corrective action</li><li>Lower maintenance and operating costs</li><li>A streamlined path to compliance and consistent quality</li></ul><h5>Who should attend this webinar series?</h5>This webinar is designed for professionals in the oil &amp; gas industry looking for hassle-free and reliable in-line fuel quality analysis, including:<ul><li>Refinery Managers &amp; Plant Managers – looking to reduce downtime and improve process efficiency</li><li>Process Engineers – wanting to minimize lab delays and bring analysis in-line</li><li>Operations Managers – seeking real-time visibility to drive better decision-making</li><li>Maintenance &amp; Reliability Teams – aiming to lower operating costs and avoid equipment-intensive solutions</li><li>Product Quality Control &amp; Lab Managers – responsible for keeping refined products on spec and compliant</li></ul>Join to learn how Process Raman gives refiners and producers the confidence to trust their in-line measurements and keep operations running smoothly.<blockquote>Presenter: Janam Pandya, PhD (Application Scientist Measurement Control and Sample Identification, Thermo Fisher Scientific)Janam Pandya, PhD is an enthusiastic scientist and spectroscopist with ten years of academic and industry experience. Janam obtained his PhD in food science from the University of Massachusetts Amherst; there his research focused on developing novel analytical methods utilizing cutting-edge Raman spectroscopic techniques. Since 2022, Janam has worked for Thermo Fisher Scientific as an application scientist, advancing the application of Raman Spectroscopy for real-time process measurements. This includes his current focus on implementing process Raman spectroscopy as a PAT tool in the clean-energy sector, among other industries.Presenter: Tom Dearing (Senior Staff Scientist, Thermo Fisher Scientific)Tom Dearing received his PhD in Chemometrics from the University of Hull in England, focusing on reaction monitoring utilizing spectroscopy and modeling. Throughout his career, he has held various chemometric positions, all aimed at enhancing decision-making processes through measurements and modeling techniques. In 2022, Tom assumed the role of Director of Chemometrics at MarqMetrix. MarqMetrix became part of Thermo Fisher Scientific in 2023.</blockquote></div></div>

Thermo Fisher Scientific: Direct In-Line Fuel & Lubricant Quality Monitoring with Process Raman

Direct In-Line Fuel & Lubricant Quality Monitoring with Process Raman

Join this webinar to see how Process Raman ensures fuel quality with direct in-line analysis, delivering reliable, real-time results without consumables

Fuel & Lubricant Quality Monitoring with Process Raman

Explore the new look and feel of the Data Analysis engine. Become acquainted with Integration Parameters and how to create a calibration curve for quantitation. Investigate new software tools such as Peak Explorer, UV and MS Spectral capabilities, library searching and matching, peak purity and more. Learn how to combine information from multiple results sets to track trends across time and instrumentation.OpenLab CDS streamlines your lab operations with a single, secure data system that combines chromatography and mass spectrometry into one software platform. Control your Agilent GC, LC, single quadrupole GC/MS, LC/MS instruments as well as other vendors’ instruments in the lab, and save substantial time managing software and training staff. New tools in OpenLab CDS provide time-saving steps in the analysis, interpretation, and reporting workflows, so you can identify key information and improve turnaround time. Optional built-in technical controls provide peace of mind for analytical labs that need the highest level of data integrity.Agilent is offering our valued customers an opportunity to increase their knowledge of OpenLab CDS in a series of live / interactive webinars. Each participant will have their own virtual image with the software loaded, configured and accessed through the web in the safety of your socially distant location. The Agilent expert will lead this virtual seminar and walk participants through a series of interactive laboratories that will allow each attendee to USE the software instead of just view a demonstration. A series of three different sessions each 2 hours in length will be offered. Each will be focused on a different aspect of the software. Feel free to attend all or just one of these seminars.<blockquote>Presenter: Richard Mutkoski (Laboratory Informatics Application Engineer, Agilent Technologies, Inc.)Richard Mutkoski has been a field representative for over 27 years for both hardware and software. In his current role as an informatics application engineer, Rich presents technical solutions of the OpenLab suite of products to customers worldwide. Prior to his tenure at Agilent Rich spent 15 years in a variety of pharma QA/QC and R&amp;D positions, providing him a unique understanding of those workflows, bottlenecks, and challenges.</blockquote>

Agilent: OpenLab CDS Seminars - Remote Sessions

Seminar 2 – OpenLab CDS – Data Analysis

Explore the new look and feel of the Data Analysis engine. 

OpenLab CDS – Data Analysis

When it comes to sustainable packaging, recycled polyethylene terephthalate (rPET) is emerging as a key material in consumer products. But how can we ensure the safety and quality of these recycled plastics?A crucial step lies in identifying and addressing impurities, such as volatile organic compounds (VOCs) and trace metals. In this session, discover how HS-20 NX Headspace Autosampler simplifies VOC analysis—detecting compounds such as acetaldehyde, benzene, and limonene—without the need for complex solvent extractions.You’ll also explore how ICPMS-2050 system efficiently identifies trace metals while reducing argon gas consumption, enabling sustainable and cost-effective workflows.Join us to uncover actionable insights and innovative solutions that ensure the safety and quality of recycled plastics. Register now!<h5>Learning Objectives:</h5><ul><li>Gain valuable insights into the use of Headspace GC-MS and ICP-MS technologies for detecting impurities in recycled plastics (rPET)</li><li>Learn how Shimadzu’s Headspace GC-MS, with its short and inert transfer line, enables direct impurity detection in rPET—eliminating the need for complex solvent extractions</li><li>Explore the capabilities of the ICPMS-2050 system, featuring Shimadzu’s Advanced Mini-Torch system, to support sustainable and cost-effective workflows</li></ul><blockquote>Presenter: Peter, Puah Perng Yang (Application Specialist (GC/GCMS), Shimadzu (Asia Pacific) Pte Ltd)Peter Puah holds a Bachelor’s degree in Industrial Chemistry and Master’s degree in Biotechnology. With a diverse background exposure in the area of biomaterial research, natural product research, and experience in chemical and waste management industries, Peter brings a wealth of knowledge to his role. As an Application Specialist at Shimadzu (Asia Pacific) Pte Ltd, he is dedicated to supporting GC and GCMS systems and developing applications solutions related to GC and GCMS analyses.Presenter: Nancy Tan Ning Xin (Application Specialist (Spectroscopy), Shimadzu (Asia Pacific) Pte Ltd)Nancy holds a bachelor's degree in Chemistry and Biology from Liverpool John Moores University in the United Kingdom. With over ten years of experience in laboratory and instrumentation processes, she has developed a strong background in testing, research and development. As an Application Specialist for Spectroscopy and TOC instruments, she leverages her expertise to conduct pre-sales demonstrations, perform sample analyses, and provide application support across a variety of industries.</blockquote>

Shimadzu: Sustainable Packaging: Advanced Impurity Analysis For Recycled Plastics

Sustainable Packaging: Advanced Impurity Analysis For Recycled Plastics

Discover how Shimadzu HS-20 NX GC-MS and ICPMS-2050 detect impurities in recycled plastics, ensuring rPET safety and supporting cost-effective sustainability.

Advanced Impurity Analysis For Recycled Plastics

This session explores the latest advancements in Agilent GC-MS instruments, focusing on intelligent instrumentation and automated workflows that enhance analytical efficiency and data quality. Attendees will gain insights into how Agilent's next-generation GC-MS platforms streamline operations and improve detection capabilities, highlighting real-life applications, ultimately improving lab productivity.Topics to be covered:<ul><li>Next Generation GC-MS Instruments: Improved intelligence and enhanced lab productivity - Ms. Poh Wei</li><li>PAL System: The modular toolbox for workflow automation - Ms. Gwen Lim</li></ul><blockquote>Presenter: Ms. Poh-Wei Tan (Product Specialist - GC/GCMS, Agilent Technologies)Ms.Poh Wei graduated with Master of Science in Analytical Chemistry &amp; Instrumental Analysis from University of Malaya. Currently, she is a Product Specialist for GC and GCMS systems. She started her career as Chemist in Environmental Laboratory with experience performing organic analysis using GCMS. Then, she broadened her exposure to various analytical techniques, and rendering technical application supports to the industries. She has around 10 years working in the analytical instruments industry, and now, her present role is focused on delivery of the GC and GCMS solutions to the market regionally.Presenter:&nbsp;Ms. Gwen Lim (Automated Sample Prep Specialist, CTC Analytics)</blockquote>

Agilent Technologies: Advancing GC-MS - Instrument Intelligence and Automated Workflows with Real Life Applications

Advancing GC-MS - Instrument Intelligence and Automated Workflows with Real Life Applications

Agilent webinar: Explore next-gen GC-MS and PAL System automation to enhance data quality, streamline workflows, and improve productivity in your lab.

GC-MS Instrument Intelligence and Automated Workflows

Traditional testing techniques used in quality control labs often require extensive sample prep, generate waste, and can have lengthy analysis times. Raman spectroscopy is a non-destructive, faster, and cleaner option with no sample prep required, no waste generated, and results provided in seconds.In our webinar on October 16, we take a closer look at these specific benefits of Raman spectroscopy and how this technology is applied for routine analysis in the modern QC lab.Join Kristen Frano, Laboratory Raman Product Manager, and myself, Dr. Michael Allen, VP Products and Marketing from Metrohm Spectro, and learn how adding next-generation Raman spectroscopy to your traditional instruments will help you speed up analysis and boost efficiency of your lab.<h5>Key learnings of this webinar:</h5><ul><li>The different types of measurements that can be made by Raman spectroscopy</li><li>Specific applications where Raman can be used for quality control</li><li>Basics of creating Raman methods to accelerate chromatography and other analytical techniques</li></ul><h5>Who should attend?</h5>Lab managers lab technicians, chemists, and everybody else interested in making their routine analysis more efficient.<blockquote>Presenter: Kristen Frano (Product Manager Spectroscopy, Metrohm Spectro)Kristen Frano joined B&amp;W Tek (a Metrohm company) in 2016 as an application scientist specializing in laboratory and handheld Raman instrumentation. Over the years, she has collaborated with users on diverse applications including polymers, art conservation, and pharmaceuticals. Since 2022 Kristen has been supporting laboratory Raman products throughout Metrohm as a product manager based at Metrohm Spectro in Plainsboro, NJ (USA).Presenter: Dr. Michael Allen (VP Products &amp; Marketing, Metrohm Spectro)Michael Allen is the VP of Products &amp; Marketing for Raman products at Metrohm. Michael and his team are responsible for developing next-generation Raman instruments and innovative applications for a variety of industries. He holds a Ph.D. in Bioanalytical Chemistry and has over 20 years of experience in commercial and marketing leadership, including 11 years with Metrohm companies.</blockquote>

Metrohm: Accelerating QC analysis with next-generation Raman spectroscopy

Accelerating QC analysis with next-generation Raman spectroscopy

We take a closer look at specific benefits of Raman spectroscopy and how this technology is applied for routine analysis in the modern QC lab.

Accelerating QC analysis with next-generation Raman

The Analytical Scientist is hosting a live roundtable discussion on sample preparation on October 21 at 3:00–4:00 PM (CEST) / 9:00–10:00 AM (EDT).Sample preparation has seen remarkable progress over the past few decades – from powerful new technologies and deeper fundamental insights to a wealth of breakthrough applications. Yet despite this momentum, sample prep is still too often seen as an “art” rather than a rigorous science, or as merely application-driven.This interactive session will challenge that perception by bringing together leading voices in the field to discuss how cutting-edge innovations are driving efficiency, precision, and reproducibility – while also addressing the growing imperative for greener, more sustainable laboratory practices.Join us for a dynamic roundtable conversation exploring the latest advances, best practices, and forward-looking strategies shaping the future of sample preparation – and take the opportunity to put your questions directly to the experts.<blockquote>Presenter: Marcela Segundo (Professor, Member of Executive Board, Faculty of Pharmacy, University of Porto)Presenter: Marcello Locatelli (Associate Professor of Analytical Chemistry, Department of Science, University "G. d' Annunzio" Chieti-Pescara, Italy)Presenter: Stig Pedersen-Bjergaard (Professor, University of Oslo, Norway)</blockquote>

The Analytical Scientist: State-of-the-Art Sample Preparation – Innovation to Sustainability

State-of-the-Art Sample Preparation – Innovation to Sustainability

Join our live roundtable discussion on pioneering new tools, greener workflows, and a bold vision for the future of sample preparation

State-of-the-Art Sample Preparation

Gas chromatography (GC) has powered analytical labs for decades, delivering precision across industries from petrochemicals to food and beverage. But traditional gas chromatography systems are often large, expensive to operate, and demanding in terms of space, utilities, and maintenance. As labs face increasing pressure to do more with less, the need for smarter, more efficient solutions has never been greater.Join James Cain, PhD, Agilent Technologies, as he showcases the latest innovations in GC-mass spectrometry (GC-MS) that are reshaping how labs approach throughput, cost-efficiency, and footprint.Plus, learn how a next-generation GC system supports both single and triple quadrupole mass spectrometry, and enables high-performance analysis across a range of applications, including gasoline aromatic composition (ASTM D5769), Total Petroleum Hydrocarbons (TPH), distilled spirits profiling, and more.<h5>Key learning objectives:</h5><ul><li>Uncover how the 8850 GC can help save bench space while using less electricity and gas for flame-ionization detectors (FID), thermal conductivity detectors (TCD), and now both single and triple quadrupole MS applications</li><li>Discover how the GC intelligence features of the 8850 can help increase system up-time through advanced system monitoring, onboard maintenance, and guided troubleshooting</li><li>Investigate how rapid heating and cooling along with precise pressure and flow control on the 8850 GC can accelerate applications with multiple examples provided.</li></ul><h5>Who should attend?</h5><ul><li>Lab analysts using GC and GC/MS who are interested in increasing efficiency and throughput</li><li>Analytical lab managers looking to save time, operational expenses, and bench space</li><li>Analytical chemists interested in the latest innovations in GC and GC/MS</li></ul><h5>Certificate of attendance</h5><ul><li>If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.</li><li>If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.</li></ul><blockquote>Presenter: James Cain, PhD (Product Manager, Agilent Technologies)James Cain, PhD, obtained his BS in Chemistry from the University of Pittsburgh and his PhD in Organic Chemistry from the University of Arizona. He has been a product manager in the GC and GC/MS business unit with Agilent Technologies for five years. He is focused on understanding the needs of GC users globally and ensuring Agilent delivers the right solutions to address them. &nbsp;Moderator: Olivia Long (Editorial Team, SelectScience)</blockquote>

Agilent Technologies: Advancing gas chromatography workflows with smarter and smaller systems

Advancing gas chromatography workflows with smarter and smaller systems

Join James Cain, PhD, Agilent Technologies, as he showcases the latest innovations in GC-mass spectrometry (GC-MS) 

Advancing GC workflows with smarter and smaller systems

<h4>Column selection basically is divided into 3 situations:</h4><ul><li>Some want to replace an existing column and need a similar type to do the exact separation. Here the challenge is to find the exact similar phase technology, which has become more difficult with the introduction of the proprietary “arylene” stabilized phases.</li><li>The other situation is that the user wants to reduce cost of operation of an existing method. Here there are many different drivers for selecting a “different” column. This can be a shorter analysis time(cost per analysis) where shorter columns of similar ID will help out, but also smaller bore columns will allow us to maintain efficiency and reduce the run time. Also a different carrier gas may be of interest to become less dependent on Helium.</li><li>Some users want a better separation or develop a new method having lower detection limits. Here a stationary phase is to be selected for the best separation.</li></ul>Modeling software allow you todo a lot of work on your laptop even before touching a GC or buying columns. Other drivers can be: need for a more robust solutions, eliminate or apply column coupling or just have a longer column life time.Several examples will be shared and discussed.<blockquote>Presenter: Jaap de Zeeuw</blockquote>

Restek Corporation: The Challenge in Column selection for GC

The Challenge in Column selection for GC

Learn key strategies for GC column selection — from replacing existing phases to cutting costs, boosting resolution, and extending column life.

Time is a critical resource in laboratory operations. However, challenges such as redundant sample data management, manual data handling and transferring of results as well as time-consuming approval processes are common in many labs.In our upcoming webinar on October 21, we will explore how digitalizing laboratory workflows address these issues head-on. Based on a best-practice example we will demonstrate how the ready-to-use interfaces of the 1LIMS Laboratory Information Management System, OMNIS Software, and some lab devices facilitate process optimization through seamless connectivity and integration. As we will demonstrate with our example workflow, time savings of more than one minute per analysis are feasible.In a Q&amp;A session at the end of this webinar, we will be happy to answer any questions you can have about digitalizing laboratory workflows. Don’t miss this opportunity and learn more about how to make your routine analysis more efficient.<h4>Key takeaways of this webinar:</h4><ul><li>Understand why connectivity is key to integrating your laboratory operations</li><li>Understand how seamless integration enables better planning and resource management</li><li>How to maximize efficiency of your laboratory operations</li><li>How to transform your laboratory into a fully integrated, digital ecosystem&nbsp;</li></ul><h4>Who should attend?</h4><ul><li>Laboratory managers, IT managers, and anyone interested in making their laboratory processes more efficient.</li></ul><blockquote>Presenter: Simon Böhm, PhD (Head of Comptence Center Software, Metrohm International Headquarters)Simon Böhm is Head of Competence Center Software at Metrohm International Headquarters in Herisau, Switzerland. He joined Metrohm Germany in 2017 as Product Specialist for titration. After being involved in rolling out OMNIS at customer sites in Germany, he took the opportunity to become global Product Manager at Metrohm International Headquarters and bring in his extensive experience. Simon studied chemistry at the University of Constance and earned his PhD from the ETH Zurich in physical chemistry.Presenter: Philipp Osterwalder (Co-founder and CEO, 1LIMS Lab and Quality Solution)Philipp Osterwalder is a skilled laboratory technician with further expertise as a biomedical analyst. While studying to become an environmental engineer specialising in eco-technology and ecological analytics, he founded 1LIMS as co-founder and current CEO to digitalize laboratories with a simple, flexible, smart solution. Today, 1LIMS is an international competence centre in lab process optimisation, laboratory digitalisation and automation, focusing on holistic expertise using lean Six Sigma.</blockquote>

Metrohm: Time is money - how digitalized workflows enhance laboratory efficiency

Time is money - how digitalized workflows enhance laboratory efficiency

Discover how OMNIS and 1LIMS integration boosts lab efficiency, saves time, and enables full digital connectivity.

Related content

Fitness for the intended use of analytical equipment and systems

New release Wiley's Mass Spectra of Designer Drugs 2026 expands coverage of emerging novel psychoactive substances

News from LabRulezGCMS Library - Week 12, 2026