Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 25th May 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you application note by Shimadzu, presentation by MDCW / University of Washington and poster by Waters Corporation!<h3>1. MDCW / University of Washington: Implementing Tile-Based Fisher Ratio Analysis of GC×GC-TOFMS Data to Obtain a Master Peak Table of All Detected Analyte Compounds in Many Petroleum-Based Samples</h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_9_Halvorsen_136808e314.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div>This presentation describes the development of a new chemometric workflow for processing GC×GC-TOFMS (comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry) data from petroleum-derived fuels. The work was conducted by researchers from the University of Washington in collaboration with Chevron Technical Center and focuses on creating a comprehensive Master Peak Table (MPT) containing all detectable analytes across multiple fuel sample classes. The motivation was that moving from conventional GC to GC×GC dramatically increased chromatographic peak capacity and resolution, but also created a need for more sophisticated data analysis methods capable of handling the much larger number of detected compounds.The analytical platform employed <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37">GC×GC-TOFMS</a> with a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1289">thermal-flow modulator</a> and a TOF mass spectrometer detector. Fuel samples were analyzed using an Rxi-1 column (30 m × 0.25 mm × 0.25 μm) in the first dimension and an Rxi-17MS column (2.0 m × 0.18 mm × 0.20 μm) in the second dimension. The sample set included multiple petroleum products such as hydrobates, reformates, naphthas, FCC gasoline, and blank samples. Log-scale chromatograms revealed numerous late-eluting trace compounds and significant compositional differences between fuel batches that were not readily visible in conventional chromatographic representations.To process these highly complex datasets, the researchers implemented a tile-based Fisher Ratio (F-ratio) chemometric approach using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/348">ChromaTOF Tile software</a>. The method divides GC×GC chromatograms into small tiles and identifies regions where analyte signals differ significantly between sample classes by comparing between-class and within-class variance. Instead of relying solely on F-ratio ranking, the workflow incorporates statistical testing against blank samples. Three blank chromatograms were used to establish tile-specific confidence intervals and p-test thresholds, allowing the system to determine whether detected signals represent genuine compounds rather than background noise. This strategy enabled the creation of a unified master peak table while minimizing problems caused by retention-time shifts and reducing the need for manual user intervention.Application of the method generated 719 statistically significant analyte hits across the fuel classes and demonstrated excellent reproducibility, with only 6.3% of classifications showing inconsistent behavior among replicates. Detected compounds included hydrocarbons and aromatic species such as 1-methylnaphthalene, 1,2,4-trimethylbenzene, β-vatirenene, 2-octene, and tetramethylheptadecane, whose occurrence patterns aligned well with expected fuel chemistry. The resulting master peak table contained both shared and sample-specific compounds and provided a much more comprehensive representation of petroleum composition than conventional workflows. The authors conclude that the approach should be broadly applicable to other complex sample types and could be extended using alternative chemometric metrics beyond Fisher Ratio analysis to address different experimental objectives.<h3>2. Shimadzu: A Simple Method for Determination of β-Sitosterol as a Marker of Vegetable Oil Adulteration in Ghee by GC</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_06_sip_gc_042_en_f4c307005b.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>ShimadzuNexis GC-2030 can be effectivelyused for determination of adulteration of Ghee with vegetable oil.</li><li>The NexisGC-2030 easily meets the acceptancecriteria as per the proposed FSSAI method no.01.097:2022.</li><li>This method is suitable for routine food industry analysis and academic research.</li></ul>The most common milk product in Indian cuisine is ghee or clarified butter. Due to its high cost, ghee is adulterated with vegetable oil, to gain commercial benefits. β-sitosterol, a common phytosterol, found in a variety of natural sources, including vegetable fat or oil from plants (Figure 1). It is used as a marker of vegetable oil adulteration in ghee1.The primary goal of this study is to assess the vegetable oil adulteration in ghee by analyzing β-Sitosterol as a marker using gas chromatography (GC). This will establish a foundation for the rapid detection of ghee adulteration. In this study, a simple, sensitive, and inexpensive method is developed for extraction of β-Sitosterol from ghee which is then subjected to gas chromatography with flame ionization detection for quantitation. The effects of several important parameters influencing the extraction efficiencies of β-Sitosterol including water-immiscible organic solvent (type and volume), volume of water, sonication time, surfactant (type and concentration), and organic modifier (type and volume) were investigated. This method is ideal for routine analysis in the food industry during the manufacturing, processing, and commercial testing of milk fat samples, or for academic research purposes.<h4>&nbsp;Sample Preparation and Analysis Conditions</h4>Standard and sample preparations were conducted following the guidelines outlined in the proposed FSSAI method No. 01.097:20222. The analysis was performed using a Shimadzu <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexis+GC-2030">Nexis GC-2030</a> equipped with a Flame Ionization Detector (FID), as shown in Figure 2. The specific configuration and analytical conditions used during the study are provided in Table 1.<h4>Conclusion&nbsp;</h4>A gas chromatography–based method using GC-2030 was developed for the estimation of β-Sitosterol in ghee. The method exhibits a detection limit of 2 %, enabling the identification of vegetable oil adulteration in ghee at levels as low as 2 %. At this adulteration level, the signal of β-Sitosterol achieved a signal-to-noise (S/N) greater than 3, confirming the reliability of detection at the established limit. This method provides a reliable and effective approach for the quantification of β-Sitosterol, which serves as a marker for vegetable oil adulteration in ghee.<h3>3. Waters Corporation: Multidimensional Characterization of Short Chain Chlorinated Paraffins (SCCPs) with GC-APCI and Cyclic Ion Mobility</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009386_3232568115.pdf">Full PDF for download</a></li></ul>This poster presents a multidimensional analytical approach for the characterization of short-chain chlorinated paraffins (SCCPs), a class of persistent environmental pollutants included in the Stockholm Convention due to their environmental persistence and bioaccumulation potential. SCCPs are highly complex mixtures of chlorinated hydrocarbons containing thousands of possible congeners, making their analysis particularly challenging. The study evaluates the use of gas chromatography coupled with atmospheric pressure chemical ionization, cyclic ion mobility spectrometry, and high-resolution mass spectrometry (GC-APCI-IMS-HRMS) as a powerful platform for improved SCCP characterization.The analytical instrumentation consisted of a modified <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890">Agilent 8890 gas chromatograph</a> equipped with an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=7&amp;search=Rxi-5SilMS">Rxi-5SilMS capillary column</a> (30 m × 0.25 mm × 0.25 μm) and connected to a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/202">Waters SELECT SERIES Cyclic IMS</a> high-resolution mass spectrometer using an Atmospheric Pressure GC (APGC) ion source. Unlike conventional electron ionization methods, APCI was operated in negative-ion mode with a chloroform modifier, promoting the formation of characteristic [M+Cl]⁻ molecular ions. This significantly reduced fragmentation and provided strong molecular-ion signals, improving both qualitative identification and quantitative analysis of SCCP homologues.Using three commercial SCCP technical mixtures (51.5%, 55%, and 63% chlorine content), the researchers demonstrated that GC-APCI-HRMS could selectively detect SCCP homologues according to carbon-chain length and degree of chlorination. Although substantial chromatographic overlap was observed among many homologues, the addition of ion mobility spectrometry (IMS) introduced a valuable extra separation dimension. Distinct drift-time versus m/z trendlines were observed for compounds sharing the same number of chlorine atoms, allowing homologues to be grouped and characterized more effectively than by chromatographic retention and mass spectrometry alone. The IMS data also enabled estimation of the relative abundance of individual homologue groups within each technical mixture.The authors further explored the resolving power of the cyclic IMS device by employing multiple ion-mobility passes (up to eight cycles) to investigate individual SCCP congeners. While complete separation of individual congeners within a homologue group was not achieved, higher ion-mobility resolution revealed measurable differences between early- and late-eluting species and provided additional insight into compositional differences among SCCP mixtures. The study concludes that combining GC-APCI, cyclic ion mobility spectrometry, and high-resolution mass spectrometry offers a powerful multidimensional workflow for the characterization of complex chlorinated paraffin mixtures and may improve environmental monitoring and future regulatory analysis of these challenging contaminants.</div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 22, 2026

Low analyte recovery is one of the most common challenges encountered during Solid Phase Extraction (SPE) sample preparation. In this Phenomenex Video Tip, Genevie Hodson, Senior Manager of Technical Support and Applications at Phenomenex, explains a practical troubleshooting approach for situations where analyte recovery after an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=6&amp;manufacturerItems=50">SPE </a>procedure is lower than expected.The key objective of troubleshooting is not simply to identify that recovery is low, but to determine exactly where the analyte was lost during the extraction process. Once the point of loss has been identified, corrective actions can be implemented systematically.<h3>Fundamental Principle of SPE Recovery Troubleshooting</h3><h4>Determine Where the Analyte Is Going</h4>The most important step when troubleshooting low recovery is to identify the location of the missing analyte.The process begins with the assumption that the sample originally contained 100% of the target analyte. If the final recovery is lower than expected, some portion of the analyte has been lost during SPE processing.To identify the loss point, each fraction generated during the SPE procedure must be collected and analyzed separately.<h5>Fractions to Collect</h5>During the SPE workflow, the following fractions should be collected individually:<ul><li>Load fraction (flow-through)</li><li>Wash fraction(s)</li><li>Elution fraction</li></ul>Each collected fraction is transferred into a vial and analyzed using the laboratory’s analytical method.The analytical results reveal whether the analyte is:<ul><li>Present in the load fraction</li><li>Present in one of the wash fractions</li><li>Present in the elution fraction</li><li>Missing from all collected fractions</li></ul>The location of the analyte provides direct information about the root cause of the recovery problem and guides the next troubleshooting steps.<h4>Scenario 1: Analyte Detected in the Load Fraction</h4><h5>What It Means</h5><ul><li>If the analyte appears in the load fraction, it was not retained by the SPE sorbent during sample loading.</li><li>Instead of binding to the stationary phase, the analyte passed directly through the cartridge.</li></ul><h5>Possible Causes</h5><ol><li>Incorrect Phase Selection</li></ol><ul><li>The selected SPE sorbent may not be appropriate for the analyte being extracted.</li><li>If the analyte cannot interact effectively with the sorbent chemistry, retention will not occur.</li></ul><ol start="2"><li>Excessively Strong Sample Solvent</li></ol><ul><li>The sample may be dissolved in a solvent that is too strong.</li><li>A strong sample solvent can prevent proper interaction between the analyte and the sorbent, causing breakthrough during loading.</li></ul><ol start="3"><li>Incorrect pH Conditions</li></ol><ul><li>Retention often depends on maintaining the analyte in the correct ionization state.</li><li>If the sample pH is not appropriate, the analyte may not interact correctly with the sorbent and therefore will not be retained.</li></ul><ol start="4"><li>Sorbent Overload</li></ol><ul><li>The SPE cartridge may have received:<ul><li>Too much analyte</li><li>Too much sample matrix</li></ul></li><li>When sorbent capacity is exceeded, analytes can break through the cartridge and appear in the load fraction.</li></ul><h5>Corrective Action</h5>When overload is suspected, increasing the amount of sorbent can improve analyte retention and prevent breakthrough.<h4>Scenario 2: Analyte Detected in the Wash Fraction</h4><h5>What It Means</h5>If the analyte appears in the wash fraction, it was initially retained but subsequently removed during the washing step.<h5>Possible Causes</h5><ol><li>Wash Solvent Too Strong</li></ol><ul><li>The most common cause is an overly aggressive wash solvent.</li><li>A wash solution with excessive elution strength can remove the analyte before the intended elution step.</li></ul><ol start="2"><li>Incorrect pH During Washing</li></ol><ul><li>When pH control is required for retention, the same conditions must be maintained throughout the process.</li><li>A pH change during washing may alter analyte retention and cause premature elution.</li></ul><h5>Corrective Action</h5>Review:<ul><li>Wash solvent composition</li><li>Wash solvent strength</li><li>pH conditions during washing</li></ul>Adjustments should ensure that the analyte remains retained until the elution step.<h4>Scenario 3: Analyte Missing from All Fractions</h4><h5>What It Means</h5><ul><li>If the analyte is not found in the load fraction, wash fractions, or elution fraction, it is likely still retained on the SPE sorbent.</li><li>In this situation, the analyte has not been effectively eluted from the cartridge.</li></ul><h5>Possible Cause</h5>Elution Solvent Not Strong Enough<ul><li>The final elution solvent may lack sufficient strength to remove the analyte from the sorbent.</li><li>As a result, the analyte remains bound to the stationary phase and never reaches the collection vial.</li></ul><h4>Corrective Action</h4><ul><li>Increase the strength of the elution solvent during the final SPE elution step.</li><li>A stronger solvent can improve analyte desorption and recovery.</li></ul><h3>Summary of Low Recovery Troubleshooting Strategy</h3>The recommended troubleshooting workflow consists of four steps:<h4>1. Collect All SPE Fractions</h4>Gather:<ul><li>Load fraction</li><li>Wash fraction(s)</li><li>Elution fraction</li></ul><h4>2. Analyze Each Fraction Separately</h4>Use the analytical method to determine where the analyte is located.<h4>3. Identify the Root Cause</h4><div><div><h5>Analyte Location&nbsp;&nbsp;/&nbsp;&nbsp;Likely Cause</h5><ul><li>Load fraction: Incorrect phase, strong sample solvent, incorrect pH, sorbent overload</li><li>Wash fraction: Wash solvent too strong, incorrect pH</li><li>Not found in any fraction: Incomplete elution from sorbent</li></ul></div></div><h4>4. Apply Corrective Measures</h4>Modify:<ul><li>Sorbent selection</li><li>Sample solvent composition</li><li>pH conditions</li><li>Sorbent amount</li><li>Wash solvent strength</li><li>Elution solvent strength</li></ul><h3>Other Common SPE Issues</h3>In addition to low recovery, several other SPE-related problems are commonly encountered.These include:<ul><li>Contamination</li><li>Reproducibility Problems</li><li>Flow-Related Issues</li></ul><h3>Conclusion</h3>Successful troubleshooting of low SPE recovery depends on identifying where the analyte is lost during the extraction process. Collecting and analyzing individual SPE fractions provides a systematic method for locating the analyte and determining the underlying cause of poor recovery.Whether the analyte passes through during loading, elutes during washing, or remains bound to the sorbent after extraction, fraction-based investigation enables targeted corrective actions. This structured approach allows SPE methods to be optimized efficiently and helps restore acceptable analyte recovery.

SPE Troubleshooting: Understanding and Resolving Low Recovery in Solid Phase Extraction

New edition of the Wiley Registry of Mass Spectral Data expands compound coverage to over 915,500 reference spectra, strengthening a foundational layer of Wiley’s scientific data and research intelligence portfolio.Wiley, a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation and learning, today released the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/887">Wiley Registry of Mass Spectral Data 2026</a>.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Registry_of_Mass_Spectral_Data_2026_bc408d8245.jpg" alt="Wiley: Registry of Mass Spectral Data 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Registry_of_Mass_Spectral_Data_2026_bc408d8245.jpg 110w," sizes="100vw" width="1527" height="2162">As AI-driven research pipelines become standard practice across pharmaceuticals, materials science and forensic investigation, the quality of reference data underpinning those pipelines determines whether results are trusted—or stall at the verification stage.The Wiley Registry of Mass Spectral Data 2026 addresses this issue directly: One of the world’s largest and most trusted mass spectral reference databases for identifying unknown chemical compounds, it is now expanded and validated to meet the analytical demands of modern, AI-assisted laboratory workflows.Laboratories face increasingly complex analytical challenges—from detecting emerging environmental contaminants to identifying novel substances in forensic investigations. As a result, having access to a comprehensive, rigorously validated spectral database has become foundational to getting results right. It is also a critical validation layer for AI-driven workflows.The Wiley Registry database helps scientists and researchers around the world with environmental testing, forensic investigation, food safety research, drug analysis, defense research, homeland security, and more, providing critical reference data for identifying and analyzing chemical compounds and materials.The new edition represents a significant expansion of the collection, which now contains more than 915,500 reference spectra—the unique chemical “signatures” used to identify substances—making it among the most comprehensive databases of its kind. More than 42,000 new GC-MS spectra representing 34,100 compounds have been added, with data from laboratories, world patents and peer-reviewed scientific literature. Each spectrum is validated to the same rigorous standard, ensuring that the data perform reliably whether a researcher is running a manual comparison or feeding it into an automated identification pipeline.The Wiley Registry is part of Wiley’s growing portfolio of scientific data and research intelligence solutions, which includes spectral databases, chemistry and materials literature, and analytical tools designed to support researchers and organizations from discovery through to applied outcomes. Wiley spectral database solutions are trusted by the world’s top pharmaceutical companies and many Fortune 500 organizations—reflecting Wiley’s mission to transform knowledge into actionable intelligence, equipping researchers with the rigorous reference data that drives real-world scientific discovery.Updated every three years, the Wiley Registry is among the company’s longest-standing data products, with a history spanning decades of continuous development.“The Wiley Registry is a foundational layer of intelligence for any laboratory conducting GC-MS analysis—and increasingly, for the AI-assisted workflows being built around that analysis,” said Armughan Rafat, Wiley senior vice president and chief AI &amp; data analytics officer. “By expanding compound coverage and applying consistent quality measures across the collection, we help analysts provide a deterministic layer to move from unknown to identified faster.”Available in the most common instrumentation manufacturer formats, the Wiley Registry of Mass Spectral Data 2026 also offers bundled options to access even more data with its <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/885">Wiley Registry/NIST</a> and the KnowItAll GC-MS Library collection for labs seeking the most comprehensive coverage and workflow integration. The Wiley Registry is also available as a KnowItAll subscription for continued access to new data as they are added to the collection.Spectral databases contain detailed “fingerprints” of substances captured through analytical techniques such as <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/934">mass spectrometry (MS)</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1271">Raman spectroscopy</a>, enabling researchers to identify unknown materials by comparing their spectral signatures against validated reference spectra. This data is essential for quality control, research verification and discovery across industries from pharmaceuticals to materials science.<blockquote>For more information about the Wiley Registry of Mass Spectral Data 2026, please <a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/solutions/technique/gc-ms/wiley-registry-of-mass-spectral-data/">visit this website</a>.</blockquote><h4>About Wiley</h4>Wiley (NYSE: WLY) is a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation, and learning. With more than 200 years at the center of the scholarly ecosystem, Wiley combines trusted publishing heritage with AI-powered platforms to transform how knowledge is discovered, accessed, and applied. From individual researchers and students to Fortune 500 R&amp;D teams, Wiley enables the transformation of scientific breakthroughs into real-world impact. From knowledge to impact—Wiley is redefining what's possible in science and learning. Visit us at Wiley.com.

Wiley releases the 2026 edition of the Wiley Registry of Mass Spectral Data to expand GC-MS identification intelligence

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Thermo Scientific MarqMetrix All-In-One X Process Raman Analyzer

Compact, portable Thermo Scientific MarqMetrix All-In-One X Process Raman analyzer for real-time, intrinsically safe process analysis in hazardous locations, enabling fast, non-destructive measurement of gases, liquids, and solids.

The Thermo Scientific MarqMetrix All-In-One X Process Raman Analyzer is a compact, portable Raman spectrometer engineered for real-time compositional analysis in hazardous locations. Designed for ease of use and rapid deployment, it delivers inherently and intrinsically safe operation where fast, confident decision-making is critical.<h4>Designed for hazardous environments</h4>Purpose-built for hazardous locations, the analyzer provides intrinsically safe optical power and on-site, real-time compositional insights. This enables operators to make faster, safer, and more informed decisions directly at the point of measurement.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_2_f4280a5f55.jpg" alt="Thermo Scientific MarqMetrix All-In-One X Process Raman Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_2_f4280a5f55.jpg 229w," sizes="100vw" width="650" height="442"><h4>Applications</h4>The analyzer is ideal for industries requiring fast and accurate results, including:<ul><li>Midstream and downstream oil &amp; gas operations</li><li>Chemical and polymer processing</li><li>Pharmaceutical development and manufacturing</li></ul><h4>Designed for use in hazardous locations</h4>The MarqMetrix All-In-One X Process Raman Analyzer supports probes engineered for safe operation in hazardous environments and compliant with ATEX Zone 0, IECEx, and Class I Division 1 certifications. These probes enable real-time analysis of gases, liquids, and solids using a single analyzer.Available probe options include:<ul><li>Thermo Scientific MarqMetrix FlowCell Sampling Optic Designed for seamless integration into continuous flow processes, this optic enables highly accurate Raman measurements without proprietary hardware. It connects easily to existing flow paths using standard industry fittings.</li><li>Thermo Scientific MarqMetrix Process BallProbe Sampling Optic Engineered for extreme environments, this probe is constructed from Hastelloy® C-276 for exceptional durability in harsh chemical and high-temperature conditions. Available in multiple diameters and chassis lengths, it delivers reliable in-line measurements for demanding applications.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_5_46cbbadfe8.jpg" alt="Thermo Scientific MarqMetrix All-In-One X Process Raman Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_5_46cbbadfe8.jpg 245w," sizes="100vw" width="650" height="327"><h4>Simple, non-destructive analysis</h4>The analyzer streamlines process analysis by eliminating the need for sample preparation and enabling fast, non-destructive, and non-invasive measurements. Its intuitive design allows straightforward setup and operation, even for users without prior spectroscopy experience. Factory calibration ensures consistent, high-precision measurements from the start, supporting scalable deployment across multiple instruments.<h4>Software and connectivity</h4>The system includes a comprehensive Raman software suite for spectral acquisition, visualization, chemometric model application, and real-time trend analysis. A dedicated integration software package supports seamless connectivity with industrial and process control systems via the Modbus communication protocol.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_4_bc7cefcb24.jpg" alt="Thermo Scientific MarqMetrix All-In-One X Process Raman Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_4_bc7cefcb24.jpg 245w," sizes="100vw" width="650" height="413"><h4>Specifications</h4><ul><li>Certifications / Compliance: Laser Certification: Class 3B laser device, reported to the FDA</li><li>Dark Noise: ≤16.5 counts at 10 s integration</li><li>Depth (Metric): 25 cm</li><li>Detector: Thermally stabilized CCD (2-stage TEC)</li><li>Fiber Conditions: FC/PC (both excitation and collection)</li><li>Height (Metric): 11.4 cm</li><li>Includes: Wireless mouse, HDMI cable, and monitor</li><li>Laser Power:<ul><li>Laser excitation wavelength: 785 nm</li><li>Excitation power: 35 mW (maximum allowable laser energy in ATEX Zone 0 environments)</li></ul></li><li>Operating Temperature Range: 15 °C to 30 °C</li><li>Resolution: 6.5 cm⁻¹ average across spectral range</li><li>Safety Features:&nbsp;<ul><li>1 keyed laser interlock switch</li><li>electronic laser trigger</li></ul></li><li>Software Details: MarqMetrix All-In-One Process Raman Analyzer Raman suite</li><li>Spectral Range: 100 to 3250 cm⁻¹</li><li>Width (Metric): 25 cm</li><li>Type: Raman spectrometer</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_3_57b8fa48b9.jpg" alt="Thermo Scientific MarqMetrix All-In-One X Process Raman Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Marq_Metrix_All_In_One_X_Process_Raman_Analyzer_3_57b8fa48b9.jpg 243w," sizes="100vw" width="650" height="418">

Thermo Scientific MarqMetrix All-In-One Process Raman Analyzer

Thermo Scientific MarqMetrix All-In-One Process Raman Analyzer enables real-time, non-destructive inline process monitoring without sample preparation, even for non-expert users.

Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer is a compact, easy-to-deploy Raman spectroscopy system designed for real-time, non-destructive process monitoring without the need for sample preparation. It delivers fast, accurate Raman spectral data directly at the point of need, enabling confident decision-making in both development and production environments.<h3>Real-time process insight—made simple</h3>The MarqMetrix All-In-One Process Raman Analyzer is engineered for reliability and ease of use. Factory calibration ensures consistent performance and portability, while one-button hardware and intuitive software allow even non-Raman specialists to obtain high-quality measurements within minutes. The small footprint supports flexible, in-line or at-line deployment across diverse processes.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Marq_Metrix_All_In_One_Process_Raman_Analyzer_5_c64e0799ee.jpg" alt="Thermo Scientific MarqMetrix All-In-One Process Raman Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Marq_Metrix_All_In_One_Process_Raman_Analyzer_5_c64e0799ee.jpg 245w," sizes="100vw" width="650" height="249"><h3>Key benefits</h3><ul><li>No sample preparation for immediate, real-time Raman results</li><li>Non-destructive and non-invasive analysis to protect valuable samples and minimize contamination</li><li>Rapid setup and operation, usable by non-experts</li><li>Compact, portable design for convenient deployment</li><li>Factory-calibrated hardware for stability and consistency</li><li>cGMP &amp; 21 CFR Part 11–ready software available for regulated environments</li></ul><h3>Application versatility</h3><ul><li>Bioproduction</li><li>Oil &amp; gas processing (e.g., refined fuels, carbon capture)</li><li>Industrial fermentation, including cultivated meat production</li><li>Polymers</li></ul><h3>Inline Raman for faster optimization</h3>Designed for continuous monitoring, the MarqMetrix system enables in-line Raman measurements that help optimize processes faster and reduce reliance on off-line testing. Its robust construction and factory calibration support continuous, precise analysis right out of the box—even when transported to the point of need.<h3>Flexible probe options</h3>A range of probes is available to match specific application requirements, including:<ul><li>MarqMetrix™ BallProbe™ Sampling Optic</li><li>Single-Use Bioreactor BallProbe™ Sampling Optic</li><li>Performance BallProbe™ Sampling Optic</li><li>Process BallProbe™ Sampling Optic</li><li>Custom BallProbe™ Sampling Optic</li><li>Fiber BallProbe™</li></ul><h3>Powerful, intuitive software</h3>Expand system capabilities with Thermo Scientific™ Lykos™ PAT Software, designed to simplify chemometrics and remote operation:<ul><li>Real-time visualization, storage, and export of process data</li><li>Remote control and monitoring from outside the lab</li><li>Intuitive workflows for non-Raman users</li><li>Centralized control of multiple MarqMetrix analyzers</li><li>Optional add-ons for cGMP &amp; 21 CFR Part 11 compliance</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Marq_Metrix_All_In_One_Process_Raman_Analyzer_4_dbff4ebc13.jpg" alt="Thermo Scientific MarqMetrix All-In-One Process Raman Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Marq_Metrix_All_In_One_Process_Raman_Analyzer_4_dbff4ebc13.jpg 235w," sizes="100vw" width="650" height="432"><h3>Service and support</h3>Comprehensive service plans from Thermo Fisher Scientific help maximize uptime and performance throughout the instrument lifecycle, including:<ul><li>Unlimited technical support</li><li>Depot repair services</li><li>Compliance maintenance</li><li>Expert consulting services</li></ul>The MarqMetrix All-In-One Process Raman Analyzer provides a practical, reliable path to real-time Raman process analytics—combining speed, simplicity, and regulatory readiness in a single, portable platform.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Marq_Metrix_All_In_One_Process_Raman_Analyzer_3_1b15997c49.jpg" alt="Thermo Scientific MarqMetrix All-In-One Process Raman Analyzer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Marq_Metrix_All_In_One_Process_Raman_Analyzer_3_1b15997c49.jpg 104w," sizes="100vw" width="433" height="650"><h3>Specifications</h3><ul><li>Certifications/Compliance: Laser Certification: Class 3B laser deviceReported to the FDA</li><li>Dark Noise: ≤16.5 counts at 10 sec. integration</li><li>Depth (Metric): 25 cm</li><li>Detector: Thermally stabilized CCD (2 stage TEC)</li><li>Electrical Requirements: Hertz: 50/60 Hz</li><li>Fiber Conditions: FC/PC (Both excitation and collection)</li><li>Height (Metric): 7.7 cm</li><li>Includes: Wireless mouse, HDMI cable, monitor</li><li>Laser Power: Laser Excitation Wavelength: 785 nm, Excitation power: 10 to 450 mW</li><li>Operating Temperature Range: 15°C to 33°C</li><li>Ports: 1RJ-45 Ethernet port 3 USB 3.0</li><li>Resolution: Spectral Resolution: 6.5 cm-1 average across spectral range</li><li>Safety Features: 1 keyed Laser interlock switch, Electronic laser trigger</li><li>Software Details: MarqMetrix Raman suite Controller: Integrated PC (Windows 10 OS)</li><li>Spectral Range: 100 to 3250 cm-1</li><li>Width (Metric): 25 cm</li><li>Unit Size: Each</li></ul>

Thermo Scientific iXR Raman Spectrometer

The Thermo Scientific™ iXR Raman Spectrometer is a research-grade Raman system for multi-modal and in-situ analysis, enabling correlation of chemical and physical material properties in real time.

The Thermo Scientific™ iXR Raman Spectrometer is a research-grade Raman system specifically designed for integration into multi-modal analytical platforms and in-situ measurements alongside complementary physical and chemical techniques. It enables simultaneous acquisition of molecular-level chemical information and physical property data from the same location and under identical conditions.Delivering performance comparable to laboratory research Raman spectrometers, the iXR is ideally suited for advanced materials research, product development, and manufacturing environments. Its open optical architecture and free-space optical coupling allow seamless integration with rheometers, extrusion systems, processing equipment, and surface analysis tools such as XPS.Raman spectroscopy with the iXR provides insight into chemical composition, matrix morphology, phase transitions, and crystallinity, with exceptional sensitivity to carbon nanomaterials including graphene and carbon nanotubes.<h3>Key Features</h3><ul><li>True multi-modal Raman analysis at the same point and time</li><li>Research-grade performance for advanced materials science</li><li>Exchangeable lasers, filters, and gratings</li><li>Free-space optical coupling for maximum throughput</li><li>Fully automatic alignment and calibration</li><li>Open architecture for custom instrument integration</li><li>Shared components, software, and data compatibility with the DXR Raman platform</li></ul><h3>Typical Applications</h3><ul><li>Materials science and engineering</li><li>Polymers, pharmaceuticals, personal care products</li><li>Phase transition and crystallinity studies</li><li>In-situ and process Raman analysis</li><li>Correlation of chemical and physical material properties</li></ul><h3>Specifications</h3><ul><li>Depth (Metric): 44 cm</li><li>Electrical Requirements: 100/240 V, 47/63 Hz</li><li>Electronic Records and Signatures: CE, UL/CSA/ETL, 21 CRF1040.10</li><li>For Use With (Application):&nbsp;<ul><li>Nanotechnology</li><li>Material science</li><li>Academic research</li><li>Pharmaceutical</li><li>Geology</li><li>Life Science/Bio-materials</li><li>Polymer</li><li>Automotive/Aero</li><li>Cosmetics</li></ul></li><li>Height (Metric): 37 cm</li><li>Laser Power: Absolute excitation laser power at the sample controlled by OMNIC software</li><li>Model: iXR</li><li>Operating Temperature Range: 16°C to 27°C</li><li>Resolution:&nbsp;<ul><li>Full range grating: average 2 cm⁻¹/CCD pixel element</li><li>High resolution grating: average 1 cm⁻¹/CCD pixel element</li></ul></li><li>Software Details: Thermo Scientific OMNIC software suite</li><li>Weight (Metric): 25 kg</li><li>Width (Metric): 29 cm</li><li>Type: Spectrometer</li><li>Unit Size: Each</li></ul>

Thermo Scientific DXR3 SmartRaman Spectrometer

Highly automated macro-sampling Raman spectrometer for routine QC and research. Push-button operation, multiple lasers, minimal sample prep, fast and reproducible results.

Thermo Scientific DXR3 SmartRaman Spectrometer is a highly automated, push-button operated Raman spectrometer designed for routine laboratory analysis. As a dedicated macro-sampling Raman system, it brings the power of Raman spectroscopy to multi-purpose analytical laboratories that require reproducible, accurate results from a reliable, low-maintenance instrument. With minimal sample preparation and fully automated workflows, the DXR3 SmartRaman is well suited for both research and quality control environments.<h3>Key Capabilities</h3><ul><li>Direct measurement through containers: analyze samples directly through glass bottles, jars, and vials (clear or colored), as well as through plastic bags.</li><li>Representative sampling of heterogeneous materials: expandable measurement spot size up to 5 × 5 mm.</li><li>High-throughput automation: accessories support automated measurements of well plates, tablet arrays, tubes, and vials.</li><li>Specialized sample cells: support high- and low-temperature measurements as well as electrochemical experiments.</li><li>Remote sampling: optional fiber-optic probes for samples too large to fit in the sample compartment.</li><li>Advanced software tools: automate analysis workflows and transform spectral data into actionable results.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3_Smart_Raman_Spectrometer_5a1544f551.jpg" alt="Thermo Scientific DXR3 SmartRaman Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3_Smart_Raman_Spectrometer_5a1544f551.jpg 156w," sizes="100vw" width="650" height="650"><h3>High Performance</h3><ul><li>Full spectral range from 3500 to 50 cm⁻¹ captured in a single CCD exposure, eliminating stitching artifacts.</li><li>User-adjustable measurement area from 10 µm to 5 mm using Variable Dynamic Point Sampling (VDPS).</li><li>Four excitation wavelengths (455, 532, 633, and 785 nm) that can be changed in less than one minute.</li><li>Automatic fluorescence correction available for all excitation lasers.</li><li>Automatic intensity correction ensures spectra are comparable across instruments and excitation wavelengths.</li><li>Multidimensional wavelength calibration provides accurate calibration across the entire spectral range.</li><li>Patented triple spectrograph delivers excellent peak shape and maintains focus at all wavelengths.</li><li>Patented algorithms for automated cosmic ray rejection and high-quality laser line filters ensure artifact-free spectra.</li><li>Depolarized lasers minimize sample orientation effects.</li><li>Laser Power Regulator continuously monitors laser power and ensures reproducible excitation over the lifetime of the laser.</li><li>Optimized gratings for each laser avoid compromises associated with shared-grating systems.</li><li>Patented autoalignment keeps the system performing in like-new condition.</li><li>Smart-backgrounds technology automatically removes the CCD dark energy profile.</li></ul><h3>Software and Spectral Databases</h3><ul><li>Extensive spectral libraries with more than 16,000 compounds.</li><li>Library search algorithms optimized specifically for Raman data.</li><li>Specta™ search software enables identification of multiple components in a single measurement.</li><li>Macro-building tools allow repetitive actions to be executed with a single button.</li><li>OMNIC™ Array supports automated data collection and analysis for array-based formats such as well plates and tablet arrays.</li><li>Automatic audit trails record all acquisition parameters and processing steps with each spectrum.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3_Smart_Raman_Spectrometer_3_abb5bee696.jpg" alt="Thermo Scientific DXR3 SmartRaman Spectrometer " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3_Smart_Raman_Spectrometer_3_abb5bee696.jpg 216w," sizes="100vw" width="650" height="471"><h3>Ease of Use</h3><ul><li>Patent-pending Autoexposure removes guesswork from optimizing exposure time and number of exposures.</li><li>Autofocusing accessories enable effortless switching between different sample types.</li><li>GO-button operation allows walk-up use: place the sample, press a button, and receive a report without interacting with a computer.</li><li>Fully automated alignment and calibration performed by the software—no user decisions required.</li><li>Smart accessories recognition automatically optimizes parameters and alignment when components are changed.</li></ul><h3>Reliability, Maintenance, and Modularity</h3><ul><li>Routine automatic alignment fully controlled by software.</li><li>Automated calibration procedures with software-driven decision making.</li><li>Automatic laser usage tracking for each installed laser.</li><li>Modular design enables flexible purchasing and future expansion without service calls or penalties.</li><li>User-replaceable lasers with SmartLock™ technology ensure reproducible results via automatic alignment and calibration routines.</li><li>Shared components (lasers, gratings, filters, accessories) can be used across multiple instruments; the system stores alignment and calibration parameters for each unique component and applies them automatically upon installation.</li></ul><h3>Laser Safety and Validation</h3><ul><li>Independently certified Class 1 laser safety for the spectrometer. (Note: optional fiber-optic probes and certain accessories are Class IIIB laser devices and require appropriate laser safety precautions and eyewear.)</li><li>Complete DQ/IQ/OQ/PQ validation package available, including extensive documentation and automated software protocols.</li><li>OMNIC™ D/S software supports 21 CFR Part 11 compliance.</li></ul><h3>Recommended Applications</h3><ul><li>Forensics: illicit drug identification, high-throughput automated measurements, and infrared ID backup for court proceedings.</li><li>Pharmaceutical analysis: differentiation of polymorphs and salt forms, tablet characterization.</li><li>Gemology: rapid identification of colored gemstones and discrimination between natural and synthetic diamonds.</li><li>Nanotechnology: bulk nanotube characterization and quality control.</li><li>Academic research: materials science, biological studies, and a wide range of applied research fields.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3_Smart_Raman_Spectrometer_4_97223d9902.jpg" alt="Thermo Scientific DXR3 SmartRaman Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3_Smart_Raman_Spectrometer_4_97223d9902.jpg 156w," sizes="100vw" width="650" height="650"><h3>Specifications</h3><ul><li>Depth (Metric): 69 cm</li><li>Description: DXR3 SmartRaman Spectrometer</li><li>Height (Metric): 46 cm</li><li>Laser Power:&nbsp;<ul><li>Fine Laser Power: Control Power controlled and reported at samples in 0.1 mW increments</li><li>Excitation Lasers: 455 nm, 532 nm, 633 nm, 785 nm</li></ul></li><li>Model: DXR3</li><li>Operating Temperature Range: 16°C to 32 °C</li><li>Optional Accessories:&nbsp;<ul><li>Universal Platform Sampling Accessory</li><li>Carousel Autosampler Sampling Accessory</li><li>180 Degree Sampling Accessory</li></ul></li><li>Resolution:&nbsp;<ul><li>Full-Range Grating: 5.0 cm⁻¹</li><li>High-Resolution Grating: 2.0 cm⁻¹</li></ul></li><li>Software Details: OMNIC Software Suite</li><li>Spectral Range: 3500 to 50 cm⁻¹</li><li>Wavelength Range:&nbsp;<ul><li>Full-Range Grating: 3500 to 50 cm⁻¹</li><li>High-Resolution Grating: 1800-50 cm⁻¹</li></ul></li><li>Weight (Metric): 56.7 kg</li><li>Width (Metric): 97 cm</li><li>Type: Spectrometer</li><li>Unit Size: Each</li></ul>

Thermo Scientific DXR3xi Raman Imaging Microscope

High-performance Raman imaging microscope offering fast, non-destructive 2D and 3D chemical imaging with intuitive workflows, automated calibration, and advanced data visualization.

The Thermo Scientific™ DXR3xi Raman Imaging Microscope delivers research-grade Raman imaging faster than ever before. Enhanced software features combined with higher spatial resolution allow users to instantly obtain detailed visual and chemical information. Advanced imaging capabilities, minimal sample preparation, and intuitive software provide researchers with the power of Raman spectroscopy at the speed modern research demands.<h3>Key features and benefits</h3><ul><li>Simple operation suitable for users of all skill levels</li><li>Faster data visualization enabled by advanced imaging software<ul><li>Advanced particle analysis for rapid identification and analysis of microscopic contaminants</li><li>3D confocal imaging for non-destructive, non-invasive three-dimensional chemical and molecular investigations</li><li>Terrain Mapping to characterize uneven sample surfaces and easily acquire in-focus Raman images</li></ul></li><li>Intuitive workflow designed for demanding applications to maximize sample throughput</li><li>Automated calibration to improve efficiency</li><li>High measurement accuracy supported by:<ul><li>Automatic alignment and calibration with no tools required</li><li>Automatic background compensation</li></ul></li><li>Rapid system reconfiguration within seconds – pre-aligned lasers, filters, and gratings can be changed without tools</li><li>Fast spectral analysis and interpretation using powerful Thermo Scientific™ OMNIC™xi Software</li><li>Advanced autofocus and morphological analysis to track positions across uneven surfaces</li><li>Visualization tools for extracting chemical contrast and identifying and ranking features of interest</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3xi_Raman_Imaging_Microscope_8_9021ee32c0.jpg" alt="Thermo Scientific DXR3xi Raman Imaging Microscope " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3xi_Raman_Imaging_Microscope_8_9021ee32c0.jpg 234w," sizes="100vw" width="650" height="433"><h3>Laser safety</h3><ul><li>Microscope designed and independently certified as Class 1 laser safe</li><li>Optional fiber optic accessories and selected components are Class 3b laser devices, requiring appropriate laser safety measures and protective eyewear</li><li>Laser path is physically blocked from the visual viewing path to prevent eye exposure during observation</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3xi_Raman_Imaging_Microscope_4_73e61c6ef9.jpg" alt="Thermo Scientific DXR3xi Raman Imaging Microscope " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3xi_Raman_Imaging_Microscope_4_73e61c6ef9.jpg 236w," sizes="100vw" width="650" height="430"><h3>Applications</h3><ul><li>Nanotechnology</li><li>Microplastics analysis</li><li>Polymer and chemical analysis</li><li>Electronics</li><li>Materials science</li><li>Academic research</li><li>Pharmaceutical research</li><li>Geology</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3xi_Raman_Imaging_Microscope_9_5d3708416c.jpg" alt="Thermo Scientific DXR3xi Raman Imaging Microscope " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3xi_Raman_Imaging_Microscope_9_5d3708416c.jpg 156w," sizes="100vw" width="650" height="650"><h3>Specifications</h3><ul><li>Electrical Requirements: 100/240 V, 47/63 Hz</li><li>Electronic Records and Signatures: 21CFR Part 11</li><li>For Use With (Application): Nanotechnology, Material science, Academic research, Pharmaceutical, Geology, Microplastics, Polymer/Chemical and Electronics</li><li>Laser Power: Fine Laser Power Control: Power controlled and reported at samples in 0.1 mW increments</li><li>Model: DXR3xi Raman Imaging Microscope</li><li>Operating Temperature Range: 16°C to 27°C</li><li>Resolution: Spatial: 0.5 µm; Confocal Depth: 2 µm</li><li>Software Details: Data analysis and spectral interpretation with powerful Thermo Scientific™ OMNIC™xi Software</li><li>Wavelength Range: 455 nm; 532 nm high brightness; 532 nm high power; 633 nm high brightness; 633 nm high power; 780 nm</li><li>Type: Raman Imaging Microscope</li><li>Unit Size: Each</li></ul>

Thermo Scientific DXR3 Flex Raman Spectrometer

Thermo Scientific™ DXR3 Flex is a research-grade Raman spectrometer designed for flexible integration with other analytical techniques, enabling combined and process Raman measurements without compromising data quality.

The Thermo Scientific™ DXR3 Flex Raman Spectrometer is a research-grade Raman spectrometer specifically designed for seamless integration with other analytical techniques. This compact system is built on the same advanced optical design and architecture as the DXR3 Raman Spectrometer research platform, delivering high-quality Raman data while enabling flexible hyphenation and portability without compromising analytical performance.Often described as a “Raman engine,” the DXR3 Flex features an open architecture that allows custom coupling to almost any type of equipment, in virtually any orientation. By combining Raman spectroscopy with complementary techniques in a single experimental setup, users can eliminate multiple measurements and assumptions, obtaining more complete answers faster.With DXR3 Flex, a single measurement can provide insight into a sample’s physical, chemical, and structural characteristics, all acquired simultaneously and under identical conditions. The system is well suited for advanced materials characterization, chemical identification, process monitoring, and real-time analysis in both research and applied environments.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3_Flex_Raman_Spectrometer_3_07d0741fcc.jpg" alt="Thermo Scientific DXR3 Flex Raman Spectrometer " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3_Flex_Raman_Spectrometer_3_07d0741fcc.jpg 201w," sizes="100vw" width="650" height="505"><h3>Key features</h3><ul><li>Open architecture enabling custom integration with a wide range of analytical and process equipment</li><li>Hyphenated measurements that combine data from multiple techniques in one experiment</li><li>Research-laboratory-level spectroscopic performance</li><li>Configurable excitation laser wavelengths and spectral resolution to optimize performance for specific materials</li><li>Free-space optical coupling to eliminate fiber-optic losses and maximize sensitivity</li><li>Broad range of available accessories, including fiber-optic coupling, macro and micro sample holders, objectives, cameras, and more</li><li>Lasers are shareable and interchangeable with Thermo Scientific™ DXR3 Raman Microscopes</li><li>Full compatibility with Thermo Scientific™ OMNIC™ Software, data formats, and spectral libraries; OMNIC D/S Software supports CFR 21 Part 11 compliance</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3_Flex_Raman_Spectrometer_2_b22261d395.jpg" alt="Thermo Scientific DXR3 Flex Raman Spectrometer " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3_Flex_Raman_Spectrometer_2_b22261d395.jpg 201w," sizes="100vw" width="650" height="505"><h3>Coupling options</h3><ul><li>Rheology systems</li><li>Hot-melt extrusion equipment</li><li>Laboratory-scale and manufacturing-scale processing equipment</li><li>Various microscopic stages and sample holders</li><li>Fiber-optic-based systems with optical input for laser delivery and output for Raman signal collection</li></ul><h3>Typical applications</h3><ul><li>Process and bioprocess monitoring</li><li>Nanotechnology</li><li>Materials science research</li><li>Academic research</li><li>Pharmaceutical analysis</li><li>Geology</li><li>Life science and biomaterials</li><li>Polymer research</li><li>Automotive and aerospace applications</li><li>Cosmetics</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3xi_Raman_Imaging_Microscope_9_5d3708416c.jpg" alt="Thermo Scientific DXR3 Flex Raman Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3xi_Raman_Imaging_Microscope_9_5d3708416c.jpg 156w," sizes="100vw" width="650" height="650"><h3>Specifications</h3><ul><li>Electrical Requirements: 100 to 240 VAC, 47 to 63 Hz</li><li>Height (Metric): 37 cm</li><li>Laser Power: Absolute excitation laser power at the sample controlled by OMNIC software</li><li>Model: Flex</li><li>Operating Temperature Range:<ul><li>Minimum temperature: 16°C</li><li>Maximum temperature: 27°C</li></ul></li><li>Resolution:<ul><li>Full range grating: average 2 cm-1/CCD pixel element</li><li>High resolution grating: average 1 cm-1/CCD pixel element</li></ul></li><li>Software Details: Thermo Scientific OMNIC software suite</li><li>Weight (Metric): 25 kg</li><li>Width (Metric): 29 cm</li><li>Type: Spectrometer</li><li>Unit Size: Each</li></ul>The DXR3 Flex Raman Spectrometer is an ideal solution for laboratories that require maximum flexibility, robust performance, and straightforward integration of Raman spectroscopy into complex analytical workflows, backed by the expertise of Thermo Fisher Scientific.

Thermo Scientific DXR3 Raman Microscope

The Thermo Scientific DXR3 Raman Microscope is an easy-to-use confocal Raman system with automated calibration, high stability, and flexible laser options for a wide range of applications.

The Thermo Scientific™ DXR3 Raman Microscope is a modern, easy-to-use point-and-shoot Raman microscope designed to provide faster, more reliable access to Raman data than ever before. Advanced imaging capabilities combined with automated system calibration deliver exceptional stability, reproducibility, and confidence in Raman measurements—even for non-specialist users.Thanks to Automated X-axis Calibration, the DXR3 system maintains long-term accuracy and reliability while minimizing user intervention. With a flexible choice of lasers and gratings, the DXR3 Raman Microscope is ideally suited for applications across pharmaceutical research, academia, advanced polymers, microplastics, and many other demanding fields.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3_Raman_Microscope_6_1dd5de4a21.jpg" alt="Thermo Scientific DXR3 Raman Microscope" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3_Raman_Microscope_6_1dd5de4a21.jpg 245w," sizes="100vw" width="650" height="299"><h3>Key capabilities</h3><ul><li>New Particle Analysis functionality for rapid identification and analysis of microparticles</li><li>High-performance confocal Raman microscopy in a robust, fully integrated design</li><li>Fully automated alignment and calibration with no tools or manual procedures required</li><li>Real-time preview, automated fluorescence correction, auto-exposure, and cosmic ray rejection</li><li>System status indicator providing at-a-glance confirmation that the instrument is optimized and ready for data acquisition</li><li>Three-path fine-beam autoalignment to maintain peak performance and sampling integrity</li><li>Active laser power regulation ensuring consistent sample excitation throughout the lifetime of the laser</li><li>Advanced spectrograph design with no moving parts for simplified operation and highly robust detection and calibration</li><li>Pre-aligned, lock-in-place components with automatic recognition and stored alignment, enabling system reconfiguration in seconds</li><li>Interchangeable lasers and components shared across the DXR3 Raman family</li><li>Optional automated polarized Raman spectroscopy for structural information complementary to chemical data</li><li>Add new excitation wavelengths without tools or service engineer intervention</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3_Raman_Microscope_2_e366caa151.jpg" alt="Thermo Scientific DXR3 Raman Microscope" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3_Raman_Microscope_2_e366caa151.jpg 204w," sizes="100vw" width="631" height="483"><h3>Laser safety</h3><ul><li>Microscope independently certified as Class 1 laser safe (Note: optional fiber-optic accessories and certain other optional components are Class 3B laser devices and require appropriate laser safety precautions and eyewear)</li><li>Laser is physically blocked from the visual viewing path, preventing eye exposure during sample observation</li></ul><h3>Validation and compliance</h3><ul><li>Complete DQ/IQ/OQ/PQ validation package available, including extensive documentation and automated software protocols</li><li>OMNIC™ D/S software supports compliance with 21 CFR Part 11</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3_Raman_Microscope_3_62f6baad12.jpg" alt="Thermo Scientific DXR3 Raman Microscope" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3_Raman_Microscope_3_62f6baad12.jpg 178w," sizes="100vw" width="630" height="553"><h3>Exceptional analytical performance</h3><ul><li>Spatial resolution down to 540 nm on ideal samples</li><li>Confocal depth resolution as fine as 1.7 µm on ideal samples</li><li>Full spectral range of 3500–50 cm⁻¹ captured in a single CCD exposure, eliminating stitching artifacts</li><li>Extended spectral range up to 6000 cm⁻¹ available with the 532 nm laser</li><li>Support for multiple excitation lasers: 455, 532, 633, and 785 nm (high-brightness and high-power options)</li><li>Automatic fluorescence correction available for all excitation lasers</li><li>Research-grade Olympus viewing optics</li><li>Automatic intensity correction enabling spectral comparability between instruments and across different excitation lasers</li><li>Multidimensional wavelength calibration ensuring accurate calibration across the entire spectral range</li><li>Proprietary Triplet spectrograph delivering exceptional peak shape and maintaining focus at all wavelengths</li><li>Software-controlled switching between confocal and high-energy collection modes</li><li>Proprietary algorithms for automated cosmic ray rejection and high-quality laser line filters for artifact-free spectra</li><li>Depolarized lasers to eliminate confusing sample orientation effects</li><li>Active laser power monitoring ensures reproducible excitation power over the laser lifetime and after laser replacement</li><li>Optimized gratings for each excitation laser, avoiding performance compromises associated with shared gratings</li><li>Proprietary autoalignment maintains the system in like-new condition</li><li>Smart-Backgrounds technology automatically removes the CCD dark energy profile</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3_Raman_Microscope_5_ca01560747.jpg" alt="Thermo Scientific DXR3 Raman Microscope" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3_Raman_Microscope_5_ca01560747.jpg 210w," sizes="100vw" width="633" height="471"><h3>Recommended applications</h3><ul><li>Forensics – trace evidence analysis and illicit drug identification</li><li>Pharmaceuticals – polymorphism studies, particulate contamination, and diffusion analysis</li><li>Art restoration and conservation – identification and characterization of pigments, resins, glazes, and inks</li><li>Archaeology – characterization of horn, shell, bone, and ceramic artifacts</li><li>Solar materials – silicon crystallinity and photovoltaic material characterization</li><li>Polymers – inclusions, gel defects, weathering effects, laminate layers, and crystallinity</li><li>Failure analysis – characterization of particulates and small surface features</li><li>Gemology – rapid identification of colored stones, differentiation of natural and synthetic diamonds, characterization of inclusions and adulterants</li><li>Nanotechnology – graphene, carbon nanotubes (CNTs), DLC coatings, and other nanostructures</li><li>Academic research – materials science, biological studies, and a wide range of applied research fields</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DXR_3xi_Raman_Imaging_Microscope_9_5d3708416c.jpg" alt="Thermo Scientific DXR3 Raman Microscope" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DXR_3xi_Raman_Imaging_Microscope_9_5d3708416c.jpg 156w," sizes="100vw" width="650" height="650"><h3>Specification</h3><ul><li>Depth (Metric): 68 cm</li><li>Description: DXR3 Raman Microscope</li><li>Electrical Requirements: 100/240 V, 47/63 Hz</li><li>Electronic Records and Signatures: 21CFR Part 11</li><li>For Use With (Application):&nbsp;<ul><li>Pharmaceutical</li><li>Microplastics</li><li>Forensics</li><li>Polymer/Chemical</li><li>Petrochemical</li><li>Material Science</li><li>Nanomaterials</li><li>Academia</li><li>Energy Storage</li><li>Art Restoration/Conservation</li></ul></li><li>Height (Metric): 61 cm</li><li>Laser Power: Fine Laser Power Control: Power controlled and reported at samples in 0.1 mW increments</li><li>Model: DXR3</li><li>Operating Temperature Range: 16°C to 27 °C</li><li>Resolution:&nbsp;<ul><li>Spatial: 1 µm</li><li>Confocal Depth: 2 µm</li></ul></li><li>Wavelength Range:&nbsp;<ul><li>455 nm</li><li>532 nm high brightness</li><li>532 nm high power</li><li>633 nm high brightness</li><li>633 nm high power</li><li>780 nm</li></ul></li><li>Weight (Metric): 66.5 kg</li><li>Width (Metric): 94 cm</li><li>Type: Microscope</li><li>Unit Size: Each</li></ul>

Products focused on RAMAN Spectroscopy distributed by Thermo Fisher Scientific (EMEA) - page 1

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