Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 24th February 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies, Knauer&nbsp; and Shimadzu!<h4>1. Agilent Technologies: Analysis of 65 Volatile Organic Compounds in Ambient Air by Canister Sampling Using an Agilent <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=8890%2F5977">8890/5977</a> GC/MSD</h4><h5>A method using both scan and SIM mode that fully meets the requirements in the HJ 759-2023 standard</h5><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_voc_air_gc_msd_5994_7723en_agilent_4b88e40417.pdf">Full PDF for download</a></li></ul>This application note introduces the use of a canister for gas sampling. Samples were introduced into an Agilent 8890 gas chromatograph (GC) with an Agilent 5977 single quadrupole mass selective detector (MSD) and the Markes Multi-Gas thermal desorption (TD), to analyze volatile organic compounds (VOCs) in the atmosphere or in semiconductor cleanrooms. The results of linearity, reproducibility, and detection limit fully met the requirements of the China method HJ759-2023. This method is widely used as a reference both in environmental laboratories and semiconductor cleanrooms. The linear correlation coefficient for all 65 compounds was greater than 0.991, with 86% of compounds having a value greater than 0.999. The results of reproducibility in scan mode varied between 0.3 to 6.8%, while results in SIM mode varied between 1.1 to 6.7%. The sampling volume was 300 mL, which resulted in detection limits of 0.013 to 0.113 nmol/mol for scan mode and 0.002 to 0.013 nmol/mol for SIM mode.&nbsp;<h4>Experimental</h4>This study was performed on an 8890 GC coupled to a 5977 single quadrupole GC/MSD with an electron ionization (EI) source. A Markes Multi-Gas thermal desorption sample introduction and preconcentration system was used and included three modules:<ul><li>CIA Advantage-xr (CIA): canister autosampler</li><li>Kori-xr: water removal module</li><li>Unity-xr: thermal desorption instrument</li></ul>First, three internal standards (ISTDs) were introduced into the Unity trap by CIA. Then, the sample was passed through a heated transfer line through the CIA Advantage into the Kori for water removal. Finally, the sample flowed into the focusing cold trap of the Unity for preconcentration. Eventually, the Unity trap was desorbed at high temperature, and the 65 VOCs and three ISTDs all entered the GC/MSD for analysis. Figure 1 shows the flow path of the combined system.&nbsp;<h4>Conclusion</h4>An Agilent 8890/5977 GC/MSD system, equipped with a Multi-Gas CIA Advantage-xr TD provides a robust analytical procedure for the analysis of 65 VOCs in ambient air. This system offers a highly efficient and highly sensitive solution for the simultaneous analysis of multiple VOCs in both atmospheric quality monitoring laboratories and semiconductor cleanrooms. Based on different application requirements, users can choose to collect data in scan or SIM mode, demonstrating the flexibility of Agilent instruments. Excellent analytical performance has been achieved based on this system both in scan and SIM mode, which fully meets the requirements detailed in method HJ 759-2023.<h4>2. Knauer: GPC vs. SPE and subsequent determination of polycyclic aromatic hydrocarbons using GC/MS</h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/VEV_0081_Comparison_of_GPC_and_SPE_purification_methods_of_sludge_samples_FINAL_web_376100390f.pdf">Full PDF for download</a></li></ul>Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants generated primarily during the incomplete combustion of organic materials. The removal of PAHs from the atmosphere by dry and wet deposition processes are strongly influenced by their gas/particle partitioning. Atmospheric deposition is a major source for PAHs in soil [1] which can be determined by various extraction and purification processes, subsequently detected by a GC/MS using the reference method UNI EN 15527. Our main purpose is to demonstrate that the purification of environmental matrix with high organic component using the gel permeation chromatography purification (AZURA GPC Cleanup, FS conditioned resins CHEX/DCM), compared to a SPE purification, allows are well-defined separation time of the analytes and it can provide narrow bands without their physical chemical interaction with the column, resulting in less chance of loss of analytes [2]. This differs from other separation techniques which depend upon chemical or physical interactions to separate analytes [3].<h4>Conclusion</h4>The GPC cleanup procedure of mud sludge samples prior analysis of PAHs with GC/MS technique is a good alternative to SPE purification steps. Advantages like better S/N ratios and third mass identification are obvious. The automatization of the GPC Cleanup using AZURA GPC Cleanup system yields high efficiency of the application.<h4>3. Shimadzu: Material Analysis of Microplastics in River Water - FTIR and Pyrolysis-GC-MS Analysis</h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00806_en_c2c7bba8be.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>Automated pretreatment of microplastics (MPs) reduces workload and enables highly reproducible pretreatment.</li><li>Material analysis of MPs processed by the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=MAP-100">MAP-100</a> device can be easily performed by <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=FTIR-ATR">FTIR+ATR.</a></li><li>Highly reproducible GC-MS analysis of MPs is possible by homogeneously pulverizing samples with Cryogenic Mill (IQ MILL-2070).</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=EGA%2FPY-3030D">Pyrolysis</a>-<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=GCMS-QP2020+NX">GC-MS</a> can measure the weight of multiple types of plastics even when they are mixed.</li></ul>Microplastics (MPs) are microscopic plastic particles measuring a few µm to 5 mm in size. They are feared to have an impact on ocean pollution and ecosystems. Against this backdrop, surveys and studies on MPs in surface waters such as oceans, rivers, lakes and marshes are being conducted worldwide. Fourier Transform Infrared Spectrophotometer (FTIR) is often used for material analysis of MPs. ASTM recently published the D8401-24 standard test method for the qualitative and quantitative determination of MPs in water that uses a pyrolysis gas chromatograph mass spectrometer (Py-GC-MS). In this application news, a sample taken from a river was pretreated and analyzed for MPs using FTIR and Py-GC-MS.<h4>Conclusion</h4>Samples collected from river water were automatically pretreated using MAP-100, and the MPs materials were then analyzed by FTIR and Py-GC-MS. PP, PE and EVA were detected in both instruments, indicating that PP and PE are the main components (Fig. 8). Using an FTIR, individual qualitative results can be obtained easily, and the number ratios and densities can be calculated. Py-GC-MS also provides a more accurate massto material ratio (%). The system supports screening methods that take advantage of the features of each instrument, from preparation to analysis of MPs.

News from LabRulezGCMS Library - Week 9, 2025

In today's data-driven world, analytical software plays a pivotal role in transforming raw data into actionable insights. These tools are the backbone of decision-making processes in industries ranging from finance and healthcare to marketing and logistics. As the volume and complexity of data continue to grow, the need for more sophisticated and efficient analytical tools becomes paramount. This necessitates regular upgrades to analytical software, ensuring that businesses can keep pace with technological advancements and evolving market demands.&nbsp;<h3>The Necessity of Analytical Software Upgrades&nbsp;</h3>Due to the complexity of the decision to upgrade software it can be always dismissed, however it should be reviewed annually to see if the benefits outweigh the disadvantages.Enhanced Performance and Speed: As datasets become larger and more complex, the processing power of older software versions often falls short. Upgrades typically come with improved algorithms and more efficient processing capabilities, allowing for quicker and more data analysis with faster generation of insights.Advanced Features and Capabilities: New versions of analytical software often include cutting-edge features such as pattern recognition visualisation, real-time data processing, and trending analytics. These capabilities enable laboratories to increase instrument uptime and troubleshoot instrument and analytical issues more swiftly.&nbsp;Improved User Experience: Upgrades frequently focus on user interface enhancements, making the software more intuitive and easier to navigate. This reduces the learning curve for new users and enhances productivity for experienced users.Compliance Enhancements: With the increasing prevalence of cyber threats, ensuring data security is more critical than ever. Upgraded software versions often come with advanced compliance with the latest industry standards, providing digital traceability of methods and results.Integration with Modern Technologies: Analytical software must integrate seamlessly with other tools and platforms used by businesses. Upgrades ensure compatibility with the latest technologies, such as Microsoft Office/Adobe products and LIMS data platforms, facilitating a more cohesive and efficient data integration.<figure class="image"><img style="aspect-ratio:997/661;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Chrom_Solutions_Software_Upgrades_Quick_Reference_Guide_a3c46947cc.jpg" alt="ChromSolutions: Software Upgrades Quick Reference Guide." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Chrom_Solutions_Software_Upgrades_Quick_Reference_Guide_a3c46947cc.jpg 235w," sizes="100vw" width="997" height="661"></figure><h3>Challenges in Upgrading Analytical Software</h3>Despite the clear benefits, upgrading analytical software can present several challenges:Costs: New software may not be back compatible with your existing PC, operating system software, instrument firmware and drivers. Even the initial investment required for new software licenses, training, and implementation can be substantial. Businesses must carefully evalu- ate the cost-benefit ratio to ensure a positive return on investment.Implementation Time: Upgrading software can be a time-consuming process, potentially leading to temporary disruptions in operations. Effective planning and project management are crucial to minimize downtime and ensure a smooth transition.&nbsp;Training: New software versions often come with new features and interfaces, requiring staff to undergo training. This can temporarily reduce productivity as employees adapt to the new system.&nbsp;Data Migration: Ensuring a seamless transfer of methods and data from the old system to the new one can be complex. Businesses must ensure that data integrity is maintained and that no critical information is lost during the migration process.<h3>The Impact of Upgraded Analytical Software</h3>Empowered Decision-Making: With access to more sophisticated analytical tools, businesses can make more informed and accurate decisions. Enhanced analytical capabilities allow for deeper insights into market trends, customer behavior, and operational efficiencies.Competitive Advantage: Companies that leverage the latest analytical tools can gain a significant competitive edge. By quickly adapting to market changes and identifying new opportunities, businesses can stay ahead of their competitors and capture a larger market share.&nbsp;Operational Efficiency: Upgraded software often includes automation features that streamline repetitive tasks, reducing the burden on human resources. This allows employees to focus on higher- value activities, improving overall operational efficiency.&nbsp;Cost Savings: While there is an initial investment associated with upgrading software, the long-term cost savings can be substantial. Improved efficiency, reduced downtime, and the ability to make better business decisions can lead to significant financial benefits.&nbsp;Enhanced Customer Experience: Advanced analytical tools enable businesses to gain a deeper understanding of their customers' needs and preferences. This allows for more personalized and targeted marketing efforts, enhancing the overall customer experience and driving loyalty.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Chrom_Solutions_Software_Upgrades_Quick_Reference_Guide_2_852a31cf7b.jpg" alt="ChromSolutions: Software Upgrades Quick Reference Guide." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Chrom_Solutions_Software_Upgrades_Quick_Reference_Guide_2_852a31cf7b.jpg 245w," sizes="100vw" width="1724" height="653"><h3>Conclusion</h3>The rapid evolution of technology necessitates regular upgrades to analytical software, providing businesses with the tools they need to stay competitive in a data-driven world. While there are challenges associated with the upgrade process, the benefits far outweigh the drawbacks. Enhanced performance, advanced features, improved user experience, and robust security measures are just a few of the advantages that upgraded analytical software brings to the table. By investing in the latest analytical tools, businesses can make more informed decisions, improve operational efficiency, and ultimately achieve greater success in their respective markets. ChromSolutions can help customers navigate all these considerations to provide a cost effective and successful outcome.<h3>ChromSolutions Ltd</h3>What we offer at ChromSolutions is our wealth of experience in analytical instrument sales and support (over 120 years distributed through the members of our company). We can help you with a cost effective software upgrades with the benefit of our partners.

Chromatography software Upgrades Quick Reference Guide

Every chromatographer knows that selecting the right fitting components is essential for the smooth operation of an HPLC system. One of the critical elements is the <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/suppliers/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky">NUT</a> – the part responsible for ensuring the ferrule creates a secure, leak-free connection.<h4>What should you consider when choosing a nut?</h4><h5>#1 Thread Types Matter</h5>External or internal? Each has its specific applications. Most nuts have “external threads“,however Some nuts have “internal threads”.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Picture_1_Different_between_Externally_Threaded_and_Internally_Threaded_Nuts_eec6ae8c86.jpg" alt="Watrex: Picture 1: Different between ExternallyThreaded and Internally-Threaded Nuts." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Picture_1_Different_between_Externally_Threaded_and_Internally_Threaded_Nuts_eec6ae8c86.jpg 245w," sizes="100vw" width="1667" height="833"><h5>#2 Head Geometry</h5>Knurled, hexagonal, square, winged? The right design makes tightening easier. Nuts come in various head designs, each suited to specific needs:<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Picture_2_Variants_of_head_geometry_20a9a263d9.jpg" alt="Watrex: Picture 2: Variants of head geometry." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Picture_2_Variants_of_head_geometry_20a9a263d9.jpg 245w," sizes="100vw" width="1667" height="833"><h5>#3 Size Matters!</h5>Nut Length: Long nuts work well in angled or tight spaces, while short nuts suit compact systems. Thru-Hole Diameter: Matches the tubing’s outer diameter.<h5>#4 Materials</h5>Stainless steel or polymer? Each material has unique advantages for diferent applications.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Picture_3_Materials_in_which_nuts_can_be_found_8541810917.jpg" alt="Watrex: Picture 3: Materials in which nuts can be found." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Picture_3_Materials_in_which_nuts_can_be_found_8541810917.jpg 245w," sizes="100vw" width="1667" height="833"><h3>Why does it matter?</h3>Choosing the right nut ensures precision, reliability, and ease of use for your HPLC system.Choose from our suppliers: <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/suppliers/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky">Vici, IDEX and Optimize Technologies</a>.Need Help Choosing the Right Nut? Contact us at: watrex@watrex.com

4 things you should know about the chromatography nuts!

Polycyclic aromatic hydrocarbons (PAHs) are a prominent class of organic compounds that have raised significant concerns due to their presence in various environmental and food matrices. These compounds are composed of multiple aromatic rings and are primarily formed during the incomplete combustion of organic matter. Sources of PAHs range from natural processes like forest fires to human activities such as vehicle emissions, tobacco combustion, and food preparation techniques like grilling or smoking.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Unveiling_the_Advanced_Workflow_for_PAH_Analysis_in_Smoke_Flavored_Foods_427c35f34b.jpg" alt="Thermo Fisher Scientific: Unveiling the Advanced Workflow for PAH Analysis in Smoke Flavored Foods." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Unveiling_the_Advanced_Workflow_for_PAH_Analysis_in_Smoke_Flavored_Foods_427c35f34b.jpg 234w," sizes="100vw" width="1024" height="683">In the food industry, PAHs are particularly relevant in the context of smoke-flavored products. While smoke flavorings enhance the sensory properties of foods, they also pose potential risks due to the formation of PAHs during the smoking process. As such, stringent analytical methods are essential for detecting and quantifying PAHs to ensure consumer safety. In this blog, we explore a comprehensive GC-MS/MS workflow specifically designed for PAH analysis in smoke-flavored foods, with a focus on innovation in sample preparation, instrumental sensitivity, and regulatory compliance.<h3 id="h-understanding-smoke-flavors-and-pahs">Understanding smoke flavors and PAHs</h3>Smoke flavorings are derived from the controlled combustion of specific wood types, which are subsequently condensed, fractionated, and purified. These flavorings are used in foods such as fish, meat, sauces, and even snacks to replicate traditional smoking processes. The primary flavoring components include phenols and carbonyl compounds (aldehydes and ketones).However, PAHs can also be introduced during this process. Examples include naphthalene (two aromatic rings), anthracene, and phenanthrene (three aromatic rings), which are considered lower molecular weight PAHs, alongside heavier compounds such as benzo(a)pyrene and coronene. Regulatory frameworks in the European Union (e.g., Regulation (EC) No. 2065/2003) ensure that only authorized smoke flavoring products are used, with maximum allowable levels for PAHs.<h3 id="h-the-challenges-of-pah-analysis-in-food-matrices">The challenges of PAH analysis in food matrices</h3>Analyzing PAHs in food matrices, particularly those with high-fat content, presents unique challenges. These include:<ol><li>Complexity of matrices: Foods like smoked trout and tofu contain fats and proteins that can interfere with analytical detection.</li><li>Stringent detection requirements: Regulatory limits demand detection of PAHs at extremely low concentrations (picogram to femtogram levels).</li><li>Sample throughput: Laboratories need workflows that are both sensitive and efficient to handle routine analysis of multiple samples daily.</li></ol><h3 id="h-a-comprehensive-workflow-for-pah-analysis">A comprehensive workflow for PAH analysis</h3><h5>1. Sample preparation: The foundation of accurate results</h5>Sample preparation is a critical step in PAH analysis, especially for fat-containing matrices. A robust and systematic approach minimizes matrix interferences and enhances analyte recovery. The workflow includes:<ul><li>Homogenization: A 5-gram sample is weighed and homogenized in a glass tube. Internal standards are added, followed by equilibration for 10 minutes.</li><li>Liquid extraction: Samples are extracted using hexane in an ultrasonic bath. This process is repeated five times to ensure thorough extraction.</li><li>Evaporation and cleanup: Extracts are evaporated to 1 mL and subjected to Solid Phase Extraction (SPE). Two SPE steps are employed:<ul><li>Primary SPE (HyperSep Florisil): Removes major interferences.</li><li>Secondary SPE (HyperSep Phenyl): Further purifies the sample for precise GC-MS/MS analysis.</li></ul></li></ul><h5>2. Advanced instrumentation: The role of GC-MS/MS</h5>Instrumentation plays a pivotal role in achieving the sensitivity required for PAH detection. The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/485">Thermo Scientific TSQ 9610 GC-MS/MS</a> system incorporates cutting-edge technologies to address the demands of PAH analysis:<ul><li>Advanced electron ionization (AEI): This ion source provides superior sensitivity through highly efficient ionization and a tightly focused ion beam. This ensures robustness even with challenging matrices.</li><li>NeverVent technology: Unique design features allow vent-free column and ion source exchanges, maximizing instrument uptime.</li><li>Dual filament design: Extends the operational lifespan and reduces maintenance frequency.</li></ul><h5>3. Importance of glass quality in analytical accuracy</h5>The quality of glass materials used in vials and liners significantly impacts analytical outcomes. Thermo Fisher Scientific’s LinerGold technology addresses the challenges posed by active glass surfaces that can adsorb PAHs, leading to signal loss or contamination. By providing highly inert glass materials, the workflow ensures consistent and accurate results.<h3 id="h-results-and-key-findings">Results and key findings</h3>The GC-MS/MS workflow for PAH analysis has been rigorously tested on various food matrices, demonstrating its robustness and reliability. Key findings include:<ul><li>Ultra-low detection limits: The system achieves femtogram-level detection, with examples such as chrysene (150 fg in smoked trout) and coronene (320 fg in smoked trout).</li><li>Precision and reproducibility: Calibration curves for compounds like pyrene and benzo(k)fluoranthene exhibit excellent linearity, ensuring reliable quantification.</li><li>Wide applicability: The workflow performs well across diverse matrices, from smoked trout to tofu, maintaining compliance with regulatory limits.</li></ul><h3 id="h-regulatory-compliance-and-consumer-safety">Regulatory compliance and consumer safety</h3>Ensuring compliance with EU regulations is a cornerstone of PAH analysis in smoke-flavored foods. The presented workflow not only meets these standards but also provides a scalable solution for routine laboratories. By integrating advanced sample preparation, state-of-the-art instrumentation, and high-quality consumables, laboratories can confidently deliver accurate and reliable results.<h3 id="h-conclusions-and-future-perspectives">Conclusions and future perspectives</h3>The detection and quantification of PAHs in smoke-flavored foods require a synergistic approach that combines meticulous sample preparation with innovative GC-MS/MS technology. The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/485">Thermo Scientific TSQ 9610</a> system, with its AEI source and NeverVent technology, sets a new benchmark in analytical sensitivity and robustness.This workflow underscores the importance of quality at every step—from sample preparation to vial selection—to achieve the necessary detection limits and regulatory compliance. As analytical demands evolve, these advancements pave the way for safer food production and enhanced consumer protection.<blockquote><h5>Additional information:</h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/485">TSQ 9610 Triple Quadrupole GC-MS</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/products-and-services/promotions/industrial/chromatography-columns-consumables-available-online.html">Chromatography Columns and Consumables Now Available Online</a></li></ul></blockquote><div><div><blockquote><h5>Join our free webinars:</h5>20.3.2025 English, 11 am CET, 1 hour <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4756">Advanced workflow for PAH analysis of smoke flavored foods</a>25.3.2025 German, 11 am CET, 1 hour <a target="_blank" rel="noopener noreferrer" href="https://event.on24.com/wcc/r/4835418/2EEB616DFE5F57C6587BA5984198FE55">Innovativer Workflow für die PAK-Analyse in Lebensmitteln mit Raucharoma</a> After the actual dates they are available on demand using the same links.</blockquote></div></div><blockquote><h5>Visit us on <a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a> #SmokeFlavors #Pah #GCMS #Consumables</h5></blockquote><section><blockquote><h4>Petra Gerhards</h4>Petra Gerhards, Dipl-Ing, is Regional Marketing Manager of GC and GC-MS for EMEA at Thermo Fisher Scientific. She has more than 29 years of experience in the fields of GC-MS, SPE and LC-MS. Since joining the regional team she has contributed to workflow solutions combining vials and closures with SPE solutions, GC-MS and LC-MS. She works with KOL's on data for regional specific marketing campaigns, organizes in-house seminars and works on customer specific solutions. Her main expertise is in the field of doping and drugs-of-abuse analysis.</blockquote></section>

Unveiling the Advanced Workflow for PAH Analysis in Smoke Flavored Foods

For analytical scientists working with chromatography and mass spectrometry, protecting sensitive information is crucial. Advances in instrument and software technology, combined with increased demands for in-depth analytics, has significantly increased the volume of valuable data that must be safeguarded from unauthorized access and potential breaches. One effective strategy to enhance security is to centralize data management, storing data away from the initial point of acquisition. Let us explore how this approach can significantly strengthen security for chromatography and mass spectrometry users and facilitate adherence to regulatory compliance measures surrounding electronic records.&nbsp;<h4>Understanding the analytical science landscape&nbsp;</h4>Chromatography and mass spectrometry are critical techniques in many fields including pharmaceuticals, environmental analysis and biochemistry. The data generated from these methods includes intricate details about potentially proprietary chemical compositions and biological information. Protecting this data is crucial to maintaining the integrity of scientific research and the competitive edge of organizations.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Enhanced_Security_Through_Centralized_Data_Management_A_guide_for_Chromatography_and_Mass_Spectrometry_Users_95f6d464f1.webp" alt="Thermo Fisher Scientific: Enhanced Security Through Centralized Data Management - A guide for Chromatography and Mass Spectrometry Users" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Enhanced_Security_Through_Centralized_Data_Management_A_guide_for_Chromatography_and_Mass_Spectrometry_Users_95f6d464f1.webp 245w," sizes="100vw" width="1200" height="600"><h4>The data security challenge&nbsp;</h4>Data acquisition, processing, storage and reporting has traditionally been conducted on isolated, static hardware-bound workstations. This approach presents significant security risks:<ul><li>Single point of failure: An isolated system with poor backup strategies can be vulnerable to catastrophic data loss via accidental damage or environmental changes. Any compromise can lead to data corruption, loss or unauthorized alterations.&nbsp;</li><li>Accessibility and convenience: Storing and processing data in a noisy lab environment can be inconvenient and impractical. Technical staff are often competing for access to instruments using the same workstation that others need for processing. This often leads to users manually transferring data outside of a controlled system for processing elsewhere. &nbsp;</li></ul><h4>The case for centralized data management&nbsp;</h4>Centralizing data management involves storing data in a central server location, away from the initial point of data acquisition. Here is how this approach can enhance security and usability for chromatography and mass spectrometry users:<ul><li>Reduced risk: A centralized system that has redundancies and backups in place can alleviate the risks associated with a single point of failure. Attackers trying to gain access will also have to deal with robust security measures not typically seen with isolated workstations&nbsp;</li><li>Enhanced data integrity: With separate systems for acquisition and storage, the integrity of the data is better preserved. Any unauthorized changes on the acquisition workstation will not directly affect the stored data.&nbsp;</li><li>Remote access and flexibility: Centralized data storage allows users to securely and conveniently access data from anywhere without manual transfer or copying the data.&nbsp;</li></ul><h4>Data retention, integrity and auditing&nbsp;</h4>Compliance with regulatory bodies such as the FDA (Food and Drug Administration) and &nbsp;EMA (European Medicines Agency) involves meeting stringent requirements for data integrity, security and retention. Centralized data management can help meet these requirements.<ul><li>Data integrity and audit trails: Separating acquisition from storage lets organizations ensure long-term raw data integrity and traceability by controlling access and providing audit trails.&nbsp;</li><li>Secure data retention: Regulations often mandate that data submissions be stored securely for extended periods. Dedicated data storage solutions can be designed to meet these requirements of large data volumes in a cost-effective way, while also protecting data from unauthorized access, accidental damage and environmental threats. &nbsp;</li></ul><h4>Practical implementation considerations for data security&nbsp;</h4>Chromatography and mass spectrometry users looking to deploy a centralized data management system should consider some data security essentials:<ul><li>Secure data transfer protocols: Use of encrypted channels for transferring data from the acquisition point to the central storage system.&nbsp;</li><li>Robust authentication mechanisms: Multi-factor authentication (MFA) to control access to both acquisition and storage systems. Single sign-on (SSO) systems also offer convenience.&nbsp;</li><li>Accessible audit trails and monitoring: Conducting regular security audits and continuous monitoring to detect and respond to potential threats promptly.&nbsp;</li><li>Leverage cloud solutions: Consider using cloud-based solutions that offer built-in security features for both data acquisition and storage. Many cloud providers offer specialized services that can help segregate these functions securely.&nbsp;</li><li>Compliance-focused data management: Ensure that the data management strategy aligns with regulatory requirements for data integrity, security and retention. This includes maintaining detailed records of data acquisition, storage, and processing activities.&nbsp;</li></ul><h4>Conclusion&nbsp;</h4>Centralizing data management by storing data away from the initial point of acquisition is a powerful strategy to enhance data security and facilitate regulatory compliance. Centralized data can be securely managed and shared remotely, allowing users to access data independently from the lab-bound workstations used for acquisition. Adopting secure data transfer protocols and robust authentication mechanisms can be made easier with modern cloud solutions. Scientists should feel empowered by these tools to protect their valuable data and maintain the integrity of their research. &nbsp;

Enhanced Security Through Centralized Data Management: A guide for Chromatography and Mass Spectrometry Users

Petr Viewegh’s Microcosm and Macrocosm

Perhaps the most compelling reason to have <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1492">Chrom SST</a> is to have a dashboard that allows you to track performance across instruments over time, be alerted to any failures requiring action or even to allow preventative maintenance based on trends before an event happens.However, the exact requirements for a dashboard can vary greatly among individuals and companies. Everyone has a slightly different vision of what it should display and how it should appear. This is why many opt for business intelligence (BI) applications like Spotfire or PowerBI to build their dashboards. Indeed, this is the approach we have taken with Chrom SST – Mgears can write the Chrom SST results to a user-supplied database, and then tools like Spotfire can be used to connect to that, allowing users to create whichever visualizations they require. In other words, we focus on what we do best – data processing and analysis – and we integrate with those who excel at dashboarding and visualization.Connecting to a database is easily achieved using Mgears. You can write to most flavors of SQL databases, using a schema we have designed or any schema you require. As this is achieved via the script engine it can be customized as needed.<h4>The SQL plugin&nbsp;</h4>Mnova has a SQL plugin that allows connection to most used database engines such as SQLite, Oracle, Postgres, and MySQL. The SQL plugin acts as a bridge between Mgears and the database, facilitating the writing of results to your chosen database. BI tools like Spotfire readily connect to these standard database sources, so, once data is being written to the DB, connecting it to the data source is straightforward. &nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Mnova_SQL_plugin_e0c300430d.webp" alt="Mestrelab Research: Mnova SQL plugin" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Mnova_SQL_plugin_e0c300430d.webp 245w," sizes="100vw" width="1379" height="365"><h4>Using an output script&nbsp;</h4>To write results to a database, we leverage Mgears’ capability to specify an output script that runs on every sample processed by the system. This allows us to tailor the behaviour of the database write to our exact needs.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Output_script_c7a78115da.webp" alt="Mestrelab Research: Output script" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Output_script_c7a78115da.webp 245w," sizes="100vw" width="967" height="547">The output tab allows an output script to be run on every sample processed – this is set up to call the script that writes to the database.&nbsp;<h4>The suggested schema&nbsp;</h4>Relational databases have a ‘schema’ – the tables and columns where data is stored within the database. We have designed a schema that allows the results of SST to be easily stored, along with an output script that writes the results to that specific schema. This provides an out of the box solution is available for writing SST results to a database. &nbsp;If you prefer to use a different schema, that is also possible. You can design your own schema and adapt the output script accordingly. You can of course use our schema as a template to refine the output to your needs.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_The_schema_used_in_the_out_of_box_solution_9b438e2260.webp" alt="Mestrelab Research: The schema used in the out of box solution." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_The_schema_used_in_the_out_of_box_solution_9b438e2260.webp 180w," sizes="100vw" width="1072" height="929"><h4>Creating a dashboard&nbsp;</h4>BI tools like Spotfire readily connect to standard database sources, so once data is being written to such a DB, connecting it to the data source is straightforward. The details are beyond the scope of this document, but many online tutorials show how to use this inbuilt functionality present in most BI tools. Below is an example of a dashboard created by a customer using Chrom SST and writing results to such a database. &nbsp;Users are free to create one or more dashboards, perhaps a high-level one to show overall status, and more detailed ones for each instrument showing history. Control charts of parameters like peak width over time are very useful in this regard as they allow preventative steps to be taken before specs fail. &nbsp;The limit is only your imagination (and the BI toll you choose!).&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Research_Creating_a_dasboard_overview_543ebfc71c.webp" alt="Mestrelab Research: View in Spotfire showing overall status and control chart, created in Spotfire from data in the SST DB." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Research_Creating_a_dasboard_overview_543ebfc71c.webp 245w," sizes="100vw" width="1280" height="422">

Making a dashboard with Chrom SST results

In the week from March 3, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a>👉 Search and filter in the largest global database with over 4 000 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Agilent Technologies: Application of GC/MS for the Analysis of Poly-Aromatic Hydrocarbons (PAHs) and Pesticides in Drinking Water According to the Directive EU 2020/2184</h5><div><div><ul><li><div>We, 5.3.2025 14:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4712">Registration</a></div></li></ul></div>The main analytical techniques for the analysis of PAHs and pesticides in GC/MS in drinking water, with particular attention to the Solid Phase Micro-Extraction (SPME) technique.</div>

Webinars LabRulezGCMS Week 10/2025

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 3rd March 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you poster by Agilent Technologies and application notes by Knauer, Shimadzu and Thermo Fisher Scientific!<h4>1. Agilent Technologies: GC/MS Approach for Analysis of Extractables and Leachables (E&amp;L) in Complex Matrices Using Spectral Deconvolution and Retention Indices</h4><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_7250_5977c_extractable_leachable_asms_2024_mp208_en_agilent_71b19d3b16.pdf">Full PDF for download</a></li></ul>Modern drug delivery systems are meant to protect a drug from environmental contamination, but they may also be a source of contamination. It is necessary to identify those compounds that can extract, leach, or migrate from the package or device. Extractables and leachables analysis presents a challenge for GC/MS because of the complexity of the various sample matrices and a diverse range of compounds to be identified. This study demonstrates how unit resolution GC/MS workflow is employed for identifying GC-amenable E&amp;L compounds by leveraging spectral deconvolution in combination with retention index-based time filtering. An addition of the accurate mass high-resolution GC/Q-TOF into the workflow provided extra confidence in compound identification, sensitivity and capability of structural elucidation.&nbsp;Operating in the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=OpenLab+ECM">OpenLab Electronic Content Management </a>(ECM) XT configuration enabled tools that help facilitate compliance with various national and EU electronic record regulations, including audit trails, and remote data storage.<h5>Experimental</h5>Rubber syringe gaskets were extracted using tetrahydrofuran (THF) solvent at room temperature for six months. An aliquot of the extracts was analyzed using both <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=GC%2FMSD">GC/MSD</a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=GC%2Fq-TOF">GC/Q-TOF</a> systems. The acquisition software operated under a unified compliance environment. The instrumental parameters are shown in Table 1. The chromatographic deconvolution and library search were performed in the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=MassHunter">MassHunter</a> Unknowns Analysis 12.1. The NIST23 library was used to perform initial compound identification. Structural elucidation was performed using Molecular Structure Correlator (MSC) software 8.2.&nbsp;Retention time locking was used to achieve the same retention times between multiple GC/MSD and GC/Q-TOF systems allowing for using both retention index and retention time matching.<h5>Conclusions</h5><ul><li>The optimized GC/MSD and GC/Q-TOF approach for analysis of extractables and leachables allowed for identifying over 150 compounds in a complex E&amp;L extract&nbsp;</li><li>High-resolution GC/MS enabled identification of over 60 additional components with increased confidence and structure elucidation of the unknowns&nbsp;</li><li>The novel ultra low bleed Agilent <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=J%26W+DB-5Q">J&amp;W DB-5Q</a> GC column resulted in significant decrease in background, that could potentially yield higher number of identifications of late eluting compounds.</li></ul><h4>2. Knauer: GPC cleanup method for soil samples before PAHs analysis</h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/VEV_0082_GPC_Cleanup_of_soil_samples_FINAL_web_5260b86091.pdf">Full PDF for download</a></li></ul>GPC (Gel Permeation Chromatography) is a size-exclusion clean-up procedure that readily separates high molecular weight interferents from sample extracts using organic solvents and a porous hydrophobic gel (primarily a crosslinked divinylbenzene-styrene copolymer) [1]. It is possible to distinguish between different types of Bio-Beads resin based on the type of cross-linkage. In this application Bio-Beads S-X3 with 200–400 mesh was used according to EPA method 3640 [1]. GPC clean-up can be used extensively in numerous environmental analysis especially for preparing sample extracts prior to semivolatile compounds determination, such as pesticide, and PAHs analysis by GC/MS or HPLC-UV-DAD. Sample cleanup is particularly important for analytical separations such as GC, HPLC, and electrophoresis because high-boiling materials can cause a variety of problems in analytical systems, like analyte adsorption in the injection port or in front of a GC or LC column [2]. GPC cleanup protects GC and HPLC columns, reduces analytical maintenance costs, improves accuracy, and allows lower detection limits.<h5>Materials and Methods</h5>Extraction of Polycyclic Aromatic Hydrocarbons was carried out using Accelerated Solvent Extraction (ASE), according to the 3545A EPA method [3]. Bio-Beads S-X are supplied dry and must be swollen prior to pack into a chromatographic column. A mixture of cyclohexane and dichloromethane (70:30, v:v) is suitable for clean-up of soil samples. As a general rule, the beads should be swollen in the same solvent chosen as mobile phase, so 10 g of Bio-Beads S-X3 were swelled with 50 mL of cyclohexane and dichloromethane mixture (70:30, v:v) overnight. After the beads were fully swollen, they were packed into a chromatographic column. Before sample cleanup, GPC column was equilibrated with the desired solvent mixture, flushing it almost three times the column volume at 1 mL/min. Cleanup method was performed with AZURA® GPC Cleanup System, which is operated with the Mobile Control Chrom® Software running on a tablet directly mounted on the system. The identification and quantification of PAHs was carried out by GC-MS/MS analysis. Calibration curves were constructed in the concentration range from 10 μg/L to 130 μg/L. To perform GC separation and MRM acquisition, optimization of the best chromatographic and detection conditions was necessary.<h5>Conclusion</h5>This application shows how to perform GPC cleanup with KNAUER AZURA® GPC Cleanup System for the analysis of PAHs in soil samples. This report is very detailed to ensure good performance in GPC cleanup for application in environmental area. We can conclude that AZURA GPC Cleanup System is an helpful tool for sample preparation before instrumental analysis because, unlike other techniques, is very useful for the removal of high boiling materials which would contaminate injection ports and column heads, prolonging column life, stabilizing the instrument, and reducing column reactivity. It could be considered an universal cleanup technique for a broad range of semivolatile organics and pesticides. Moreover, AZURA GPC Cleanup System allows the customer to process many extracted samples, with a reduction in time for the cleanup procedures.<h4>3. Shimadzu: Blood alcohol content (BAC) analysis using a liquid injection approach</h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/AP_Blood_alcohol_content_via_liquid_injection_SCA_180_051_294d6843f8.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>Blood alcohol analysis using liquid injection is an alternative to the headspace</li><li>analysis of blood samples for clinical purposes</li><li>It provides reliable results for whole blood and plasma samples without adverse matrix effects&nbsp;</li></ul>Blood alcohol content (BAC) is relevant for legal regulations regarding driving limits, but also investigated for forensic and clinical purposes with respect to poisoning. Blood alcohol analysis does not only focus on ethanol, which is the classical drinking alcohol, but also investigates other alcoholic substances like methanol and isopropanol as well as metabolites like acetone. Ethanol is present in alcoholic beverages, but also used for antiseptics, various daily life products, and pharmaceuticals. Being a central nervous system depressant, consumption can cause severe intoxication with toxic levels at above 100 mg/dL blood [1]. Methanol intoxication could originate from the consumption of counterfeit alcohol, with as few as 30 mL pure methanol consumed being potentially lethal [2]. Isopropanol is widely used as solvent or antiseptic in households and sometimes used as cheap substitute for ethanol by alcohol abusers. It is metabolized by alcohol dehydrogenase to acetone, which alike isopropanol is a central nervous depressant [3].Blood alcohol analysis can be performed using gas chromatography (GC) with flame-ionization detection (FID). Due to the complexity of blood as matrix, headspace analysis is a widely used technique for simple sample transfer onto the GC column, which is especially valuable in forensics, where the matrix states investigated can drastically vary depending on the time the sample is taken. For clinical analysis, fresh blood is used, making the sample more uniform. In this approach, the analysis of BAC using a liquid injection technique as alternative to headspace sampling is presented.<h5>The Package</h5>The recommended analytical hardware and software configuration is listed below.<ul><li>Main Unit<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=nEXIS+gc-2030+%28fid%29">Nexis GC-2030 with FID-2030</a>: Gas chromatograph with flame ionization detector</li></ul></li><li>Accessory<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=AOC-30i+">AOC-30i </a>autosampler: Liquid autosampler with 30 vials capacity</li></ul></li><li>Main Consumables<ul><li>SH-BAC1 column (30 m x 0.32 mm x 1.8 µm;</li><li>P/N 221-76135-30)</li></ul></li><li>Software<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=LabSolutions+LCGC">LabSolutions LCGC</a></li></ul></li></ul><h4>Conclusion</h4>Liquid sample injection presents a reliable alternative to headspace injection when analyzing blood samples for clinical purposes. Ethanol and methanol can be determined from whole blood, isopropanol and acetone from plasma samples without adverse matrix effects. Both whole blood and plasma analysis can be done using the same analytical method and one data processing approach, facilitating data evaluation and routine work.<h4>4. Thermo Fisher Scientific: Trace analysis of volatile organic compounds in wastewater according to U.S. EPA Method 624.1&nbsp;</h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/an_003068_gc_gc_ms_isq_7610_epa_624_1_an003068_na_en_2297d596f3.pdf">Full PDF for download</a></li></ul>It is crucial that analytical testing laboratories monitor wastewater for the presence of volatile organic compounds (VOCs). VOCs are human-made contaminants used and produced in the processing of paints, adhesives, petroleum products, pharmaceuticals, and refrigerants. If they are released into wastewater from industrial activities, they can have an adverse effect on the natural environment and, ultimately, the public.1 U.S. EPA Method 624.1 is an approved test method under the Clean Water Act2 for determination of purgeable organic pollutants in industrial discharges and other environmental samples. The accurate detection and quantitation of VOCs via this method help ensure wastewater is not contaminated. Due to technological advances in analytical instrumentation and techniques, U.S. EPA Method 624.1 allows the analyst to modify P&amp;T parameters and GC/MS conditions. This can result in reduced sample run time and increased laboratory throughput in a 12-hour period.&nbsp;To perform U.S. EPA Method 624.1, method acceptance criteria must be achieved. These criteria include creating a working calibration curve, method detection limits (MDLs), and Initial Demonstration of Capability (IDC) of accuracy and precision for target compounds. As the sample matrix is water, it is essential that moisture is reduced, limiting the impact on the analytical column as this could damage the column and affect the results.&nbsp;The following evaluation describes the use of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=ISQ+7610">ISQ 7610</a> GC-MS system coupled with a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=TRACE+1610">TRACE 1610 GC</a> equipped with the Thermo Scientific™ HeSaver-H2 Safer™ split/splitless injector and a Teledyne LABS Tekmar Lumin P&amp;T concentrator paired with the AQUATek LVA autosampler for U.S. EPA Method 624.1 for the analysis of wastewater.<h5>Experimental</h5><h5>GC-MS parameters&nbsp;</h5>A TRACE 1610 GC was coupled to the ISQ 7610 MS equipped with a Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=NeverVent">NeverVent™ </a>vacuum probe interlock (VPI) and a Thermo Scientific™ ExtractaBrite™ ion source. A Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=TraceGOLD">TraceGOLD™ TG-VMS</a>, 30 m × 0.25 mm, 1.4 µm film column (P/N 26080-3320) was used for compound separation. The HeSaver-H2 Safer injector was utilized which reduces the carrier gas consumption by decoupling the gas used for the chromatographic separation from the gas used to pressurize the inlet and maintain split and purge flows. The critical separations were maintained with a run time of under 13 minutes.&nbsp;For this analysis, the ISQ 7610 MS was operated in full scan mode, ensuring the sensitivity needed for required the method detection limits. Nevertheless, the instrument could operate in Selected Ion Monitoring (SIM) mode for increased selectivity, if needed. Extended method parameters for the ISQ 7610 MS are shown in Table 2.<h5>Conclusion</h5>The ISQ 7610 MS system with the VPI coupled with the Teledyne LABS Tekmar Lumin P&amp;T concentrator paired with the AQUATek LVA autosampler exceeds all the requirements outlined in U.S. EPA Method 624.1 for analysis of VOCs in wastewater:<ul><li>MDLs calculated from n=7 repeat injections of 0.5 ppb water standards showed no interference from unwanted water entering the system and resulted in values &lt;0.15 ppb for most compounds.</li><li>Precision and accuracy for n=7 20 ppb water standards showed excellent results with %RSD &lt;20% and mean recovery of 93% for the compounds.</li><li>System robustness was tested by continuously acquiring 209 injections of water samples over two days with no user intervention at all. The average %RSD of the calculated concentration was 6.5% over this robustness study.</li><li>Utilizing the HeSaver-H2 Safer technology reduced helium consumption for the method by 4 times, reducing laboratory overheads.&nbsp;</li></ul>Further information on VOC analysis using the ISQ 7610 system and the Tekmar Lumin P&amp;T paired with the AQUATek LVA can be found in the Thermo Fisher Scientific AppsLab library.3 &nbsp;

News from LabRulezGCMS Library - Week 10, 2025

In the week from March 10, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a>👉 Search and filter in the largest global database with over 4 000 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Thermo Fisher Scientific: Detecting Volatile PFAS in Water with High-Resolution GC-MS</h5><ul data-start="231" data-end="400"><li data-start="231" data-end="333">Tuesday, March 11, 2025, 11:00 CET</li><li data-start="334" data-end="400"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4812">Registration</a></li></ul>Join Principal Scientist John Quick from ALS Environmental Ltd for a webinar on using GC-HRMS to analyze fluorotelomer alcohols (FTOHs) and other volatile per- and polyfluoroalkyl substances (PFAS) in water samples.​<h5>2. Separation Science/SepSolve Analytical: From Bottlenecks to Breakthroughs: Overcoming GC–MS Limitations in Non-Target Screening</h5><ul data-start="524" data-end="691"><li data-start="524" data-end="607">Tuesday, March 11, 2025, 11:00 CET​</li><li data-start="608" data-end="691"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4739">Registration</a></li></ul>This webinar will demonstrate how comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC×GC–TOF MS) transforms non-target screening, with practical examples from sustainable fuel analysis, aroma profiling, and essential oil characterization.​<h5>3. Phenomenex: SPE Troubleshooting: Unlock Maximum Recovery with Expert Tips!</h5><ul data-start="865" data-end="1040"><li data-start="865" data-end="952">Tuesday, March 11, 2025, 11:00 CET</li><li data-start="953" data-end="1040"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4765">Registration</a></li></ul>Learn how to successfully troubleshoot Solid Phase Extraction (SPE) problems quickly and efficiently to maximize recovery in your analyses.​<h5>4. Thermo Fisher Scientific: Real-time Monitoring of Polymer Blend Extrusion Using an Inline Process Raman Analyzer</h5><ul data-start="1252" data-end="1427"><li data-start="1252" data-end="1339">Tuesday, March 11, 2025, 15:00 CET​</li><li data-start="1340" data-end="1427"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4793">Registration</a></li></ul>This webinar will explore findings from a recent study where a process Raman analyzer was coupled to a parallel twin-screw extruder for continuous in-line monitoring of polymer extrusion.<h5>5. SelectScience/VELP Scientifica: Maximize Efficiency in Fat and Oil Extraction for Quality Control and Compliance</h5><ul data-start="1633" data-end="1808"><li data-start="1633" data-end="1720">Tuesday, March 11, 2025, 16:00 CET​</li><li data-start="1721" data-end="1808"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4842">Registration</a></li></ul>In this educational webinar, Corey Letizio from Thermo Fisher Scientific will discuss strategies to maximize efficiency in fat and oil extraction processes, focusing on quality control and compliance.​<h5>6. New Food Magazine/Nordson Measurement &amp; Control Solutions: Delivering Closed Loop Control in Baking and Frying Processes Through Online Measurement</h5><ul data-start="2015" data-end="2190"><li data-start="2015" data-end="2102">Wednesday, March 12, 2025, 15:00 CET​</li><li data-start="2103" data-end="2190"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4768">Registration</a></li></ul>Join this webinar to hear from Nordson as they discuss the benefits of simultaneous online measurement of moisture, fat/oil, protein, and color in the baking and frying industries.<h5>7.SelectScience/Thermo Fisher Scientific: Reducing the environmental impact of lab plastics with plant-based solutions</h5><ul data-start="2015" data-end="2190"><li data-start="2015" data-end="2102">Wednesday, March 12, 2025, 17:00 CET​</li><li data-start="2103" data-end="2190"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4843">Registration</a></li></ul>In this webinar, hear from experts, as they share insights on using traditional plastic-based resins compared with plant-based, focusing directly on the impact on the mass balance approach.<h5>8. Waters Corporation: Empower Tips: Ask Me Anything About the Importance of Keeping Laboratory Software Updated</h5><ul data-start="2399" data-end="2574"><li data-start="2399" data-end="2486">Thursday, March 13, 2025, 16:00 CET​</li><li data-start="2487" data-end="2574"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4797">Registration</a></li></ul>This webinar covers Empower and NuGenesis, key reasons to stay updated on software versions, and practical approaches to upgrading.<h5>9. PerkinElmer: Empower The Role of Analytical Chemistry in Battery Development &amp; Production</h5><ul data-start="2399" data-end="2574"><li data-start="2399" data-end="2486">Thursday, March 13, 2025, 18:00 CET​</li><li data-start="2487" data-end="2574"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4845">Registration</a></li></ul>In collaboration with PerkinElmer, this presentation will explore the critical role of analytical chemistry and thermal analysis in ensuring battery efficiency, safety, and performance.<h5>10. Agilent Technologies: FTIR Theory</h5><ul data-start="2707" data-end="2882"><li data-start="2707" data-end="2794">Thursday, March 13, 2025, 20:00 CET​</li><li data-start="2795" data-end="2882"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4555">Registration</a></li></ul>The intricate details of Fourier-transform infrared (FTIR) spectroscopy and data collection will be explained in this session.​

Webinars LabRulezGCMS Week 11/2025

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Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

Thermo Fisher Scientific

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

SciY, a vendor-agnostic Bruker BioSpin division, drives R&D and manufacturing digitalization and automation. Its harmonized solutions cover experiment design, data management, analysis, automation, and AI readiness, empowering next-generation self-driving labs and factories.

SciY/Mestrelab Research

ChromSolutions Ltd was formed in 2004 and has a wealth of experience in sample preparation for chromatography and spectroscopy techniques. With over 120 years of collective experience ChromSolutions offer an independent source of advice and solutions for modern analytical challenges.

ChromSolutions

WATREX Prague is the distributor and producer of HPLC techniques in the Czech Republic and Slovakia. Main Chromatografic and Related Techniques Supported: LC, GPC, IC, IEC, Automated SPE, LC Columns and special column packings, LC method development, Software development, Laboratory Robots.

Webinars LabRulezGCMS Week 11/2025

Making a dashboard with Chrom SST results

News from LabRulezGCMS Library - Week 10, 2025

Unveiling the Advanced Workflow for PAH Analysis in Smoke Flavored Foods

Webinars LabRulezGCMS Week 10/2025

Chromatography software Upgrades Quick Reference Guide

4 things you should know about the chromatography nuts!

Petr Viewegh’s Microcosm and Macrocosm

Enhanced Security Through Centralized Data Management: A guide for Chromatography and Mass Spectrometry Users

News from LabRulezGCMS Library - Week 9, 2025

Upcoming events

36th MassSpec Forum Vienna 2026

US HUPO 2026

Thermo Fisher Scientific at US HUPO 2026

Webinars

Small Size, Big Impact – High-Performance Benchtop GC and GC/MS with the Agilent 8850 GC

Dynamic Blender

Ask Me Anything About Managing Computerized System Risks to Data Integrity