<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 22nd July 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p>
<blockquote>
<h4>👉 <a href="https://gcms.labrulez.com/library"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p>
</blockquote>
<p>This week we bring to you poster presentations from <a href="https://gcms.labrulez.com/events/568"><strong>ASMS 2024</strong></a> by <strong>LECO</strong>, <strong>Agilent Technologies</strong>, and <strong>Thermo Fisher Scientific</strong>! And as a bonus two application notes from <strong>Shimadzu</strong> and <strong>Thermo Fisher Scientific</strong>.</p>
<blockquote>
<p>💡 <strong>+ 100 ASMS posters and presentations <a href="https://gcms.labrulez.com/library?mainauthorItems=284">available in the LabRulezGCMS library</a></strong> (unique search and filtering)</p>
</blockquote>
<h4><strong>1. LECO: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Long_Lifetime_Ion_Detector_GC_G_Cx_GC_TOFMS_MS_ASMS_24_LPSS_326_4c9e1fb7a1.pdf">A Novel Long-Lifetime Ion Detector for GC-TOFMS and GCxGC-TOFMS with Sub-Femtogram Detection Limits</a></strong></h4>
<ul>
<li>poster - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong> Ion detection efficiency and fast response times are critical aspects of the ion detectors used in time-of-flight mass spectrometry (TOFMS). With modern advancements in ionization, ion optics, and ion transfer efficiency, TOFMS systems are capable of generating high ion flux onto the ion detectors. Having an ion detector that is capable of maintaining optimal performance over a long period of time while accepting high amounts of ion flux is a significant challenge in development of TOFMS instrumentation. Improvements in detector life will minimize maintenance costs and improve TOFMS user experience. A novel long-lifetime ion detector was developed in partnership with El Mul Technologies for use in LECO’s Pegasus® BTX GC and GCxGCTOFMS. The system was thoroughly evaluated for sensitivity and robustness, including longevity of the detector.</p>
<p><strong>Conclusions:</strong> The Pegasus BTX GC(GCxGC)-TOFMS with a novel Long-Lifetime Ion Detector has demonstrated the following performance characteristics:</p>
<ul>
<li>Sub-2 fg IDL for GC-TOFMS and Sub-fg IDL for GCxGC-TOFMS </li>
<li>Linear dynamic range of 5 orders of magnitude in GC-TOFMS and 4 orders of magnitude in GCxGC-TOFMS</li>
<li>Robust operation: the detector bias remains consistent and BTX peak intensity remains consistent over long periods of time, even with large numbers of samples acquired and significant amounts of charge accumulation on the detector.</li>
</ul>
<h4><strong>2. Thermo Fisher Scientific: <a href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/po_142_utilizing_hydrogen_pesticides_food_gc_ms_po142_asms2024_en_7ed0951b93.pdf">Utilizing hydrogen carrier gas for sensitive analysis of pesticides in food using gas chromatography mass spectrometry</a></strong></h4>
<ul>
<li>poster - ASMS 2024</li>
</ul>
<h5><strong>Abstract</strong></h5>
<p><strong>Purpose:</strong> To demonstrate the performance of the Thermo Scientifc HeSaverH2Safer kit for iConnect split-splitless (SSL) injection module for trace analysis of pesticides using H2 as a carrier gas as a safe and sustainable solution for laboratory operations.</p>
<p><strong>Methods:</strong> In this study, hydrogen was used as a carrier gas for GC-MS/MS analysis of trace levels of pesticides in food. The GC was fitted with a new hydrogen safer split/splitless injector, with chromatographic separation performed on a TG-5 SIL MS(30 m × 0.25 mm, 0.25 μm) capillary GC column. The chromatographic conditions applied ensured critical pair separation was achieved. The GC-MS/MS system was equipped.</p>
<h5><strong>Conclusions</strong></h5>
<ul>
<li>The use of the HeSaver-H2Safer technology allows for a safe and compliant use of hydrogen as an alternative carrier gas in GC/GC-MS applications without the need to install a hydrogen sensor and removes any risk of unwanted reactions with the sample in the hot SSL injector.</li>
<li>When used with hydrogen, the limited carrier gas consumption offered by the HeSaverH2Safer mode permits a very controlled system demand for hydrogen, making this solution ideal for laboratories working with hydrogen generators.</li>
<li>Migrating the GC-MS/MS method from helium to hydrogen requires an adaptation of method parameters to address (i.e., retention time shift and different fragmentation patterns).</li>
<li>97% of pesticides in baby food and 98% in honey showed a linear response in the concentration range 0.005–0.500 mg/kg and the relative standard deviation for N=5 repeats of each sample type at 0.01 mg/kg was equal or lower than 10% for 98% of the evaluated compounds with an advanced electron ionization (AEI) source to increase sensitivity for analyte detection. Quantification and assessment of critical regulatory requirements, such as linearity and sensitivity, were performed in a single software.</li>
</ul>
<h4><strong>3. Agilent Technologies: <a href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/po_142_utilizing_hydrogen_pesticides_food_gc_ms_po142_asms2024_en_7ed0951b93.pdf">Analyzing Nitrosamines with Hydrogen Carrier Gas: GC/MS/MS Analysis of Nitrosamines in Sartan Drugs</a></strong></h4>
<ul>
<li>Poster Reprint - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong> The limited availability of helium has been a concern, leading to a growing interest in switching to alternative carrier gases like hydrogen. Hydrogen offers several advantages over helium1 , including faster run times and improved chromatographic resolution. Helium is commonly used as a carrier gas for analyzing nitrosamine impurities in pharmaceuticals. However, there are concerns that nitrosamines may react with hydrogen, forming unwanted byproducts. To ensure that using hydrogen as a carrier gas does not impact spectral quality, we evaluated its suitability for analyzing eight impurities:</p>
<ul>
<li>N-nitrosodimethylamine (NDMA),</li>
<li>N-nitrosomethylethylamine (NMEA),</li>
<li>N-nitrosodiethylamine (NDEA),</li>
<li>N-nitroso-ethylisopropylamine (NEIPA),</li>
<li>N-nitrosodiisopropylamine (NDIPA),</li>
<li>N-Nitrosodipropylamine (NDPA),</li>
<li>N-nitrosodi-n-butylamine (NDBA),</li>
<li>N-Nitrosopiperidine (NPIP).</li>
</ul>
<p>Hydrogen carrier gas was used with the 7000E and 7010 Series GC/TQ systems equipped with the HydroInert and HES ion sources respectively, assessing spectral quality, linearity, repeatability, recovery, and compliance with nitrosamine analysis regulations.</p>
<p>MassHunter 13 software suite provided the tools for data acquisition and processing to be performed under a unified compliance environment. OpenLab Electronic Content Management (ECM) XT includes native tools to facilitate compliance, including the ability to create users with affiliated permissions, the generation of audit trails, and remote data storage.</p>
<p><strong>Conclusions:</strong></p>
<ul>
<li>The 7000E and 7010 Series GC/TQ systems equipped with the HydroInert and HES, respectively, exhibited exceptional performance in determining eight nitrosamine drug impurities in sartan drug products and substances using hydrogen carrier gas.</li>
<li>The method was validated at 30 ppb with acceptable recovery and long-term repeatability. </li>
<li>The 7010 Series GC/TQ system enabled a smooth switch between helium and hydrogen carrier gas without compromising the performance of the methods. </li>
<li>Both the HydroInert and the HES sources facilitated achieving the necessary detection limits for the tested impurities.</li>
</ul>
<h4><strong>4. Agilent Technologies: <a href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/po_142_utilizing_hydrogen_pesticides_food_gc_ms_po142_asms2024_en_7ed0951b93.pdf">Analysis of Essential Oils Using a Comprehensive GCxGC with a Reverse Flow Modulator Combined with High Resolution GC/MS</a></strong></h4>
<ul>
<li>Poster Reprint - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong> Essential oils are typically analyzed to determine their chemical composition contributing to flavor and quality as well as to evaluate their authenticity and identify adulterants. Essential oils are often complex samples with high number of volatile and semi-volatile components that include many isomers with highly similar spectra and close Retention Indices (RIs) when separated on a single column. Hence, a comprehensive GCxGC approach is preferable to achieve an appropriate chromatographic separation for this sample matrix. In this study we used comprehensive GCxGC coupled to a high-resolution accurate mass GC/MS to identify the essential oil  components. Here we also investigate approaches for comparison of the complex GCxGC essential oil data.</p>
<p><strong>Conclusions:</strong></p>
<ul>
<li>Several comprehensive GCxGC configurations and method using the high-resolution GC/Q-TOF and RFM were developed and optimized using a diesel sample. </li>
<li>Essential oils were analyzed using the optimized GCxGC approach, and the workflows for compound identification and statistical analysis were evaluated.</li>
</ul>
<h4><strong>5. Shimadzu: <a href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/an_01_00746_en_e14cf49b7b.pdf">Greenhouse Gas Analyzer</a></strong></h4>
<ul>
<li>Application</li>
</ul>
<p><strong>User Benefits:</strong></p>
<ul>
<li>Simultaneously measures the 3 main greenhouse gases: CH₄, CO₂, and N₂O.</li>
<li>Offers short analysis cycle times and is equipped with an AOC-6000 Plus syringe injection system to analyze large numbers of samples.</li>
<li>Uses nitrogen as a carrier gas for lower running costs.</li>
</ul>
<p><strong>Introduction:</strong> Greenhouse gases are a major cause of climate change, and carbon dioxide, (CO₂), methane (CH₄), and nitrous oxide (N₂O) are considered the 3 primary greenhouse gases. Although CO₂ accounts for the majority of greenhouse gas emissions followed by CH₄, reducing CH₄ emissions is considered important because CH₄ has a warming effect that is more than twenty times greater than CO₂. At the United Nations Climate Change Conference (COP26) in November 2021, over 100 countries joined the Global Methane Pledge, which pledges by 2030 to reduce global CH₄ emissions by 30 % compared to 2020 levels. The Greenhouse Gas Analyzer is a gas chromatography system that has been developed by Shimadzu in collaboration with the National Agriculture and Food Research Organization (NARO) (Fig. 1). Measuring levels of CH₄, CO₂, and N₂O simultaneously in a single sample is difficult, but the Greenhouse Gas Analyzer has been designed to do this simultaneously, which reduces analytical errors and improves the sampling speed, giving researchers a valuable tool in reducing greenhouse gas emissions.</p>
<p>This Application News describes using the Greenhouse Gas Analyzer to simultaneously measure CO₂, CH₄, and N₂O levels.</p>
<p><strong>Conclusion:</strong> The Greenhouse Gas Analyzer can simultaneously measure 3 greenhouse gases in atmospheric air in a single analysis. Each analysis by the Greenhouse Gas Analyzer is performed in 8 minutes with an analysis cycle time of 10 minutes.</p>
<h4><strong>6. Thermo Fisher Scientific: <a href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/an_002695_gc_triplus_rsh_smart_sample_prep_environ_an002695_na_en_77a5aa2300.pdf">An automated approach for the analysis of VOCs in drinking and surface water by using the TriPlus RSH SMART VOC Sample Prep Station</a></strong></h4>
<ul>
<li>Application - Environmental</li>
</ul>
<p><strong>Goal:</strong> The aim of this study is to demonstrate the suitability of the Thermo Scientific™ TriPlus™ RSH SMART VOC Sample Prep Station for the analysis of volatile organic compounds (VOCs) in drinking and surface water by using a fully automated sample preparation workflow.</p>
<p><strong>Keywords:</strong> Automated sample preparation, TriPlus RSH SMART Sample Prep Station, volatile organic compounds, VOCs, drinking water, surface water, gas chromatography, TRACE 1610 GC, single quadrupole mass spectrometry, ISQ 7610 GC-MS.</p>
<p><strong>Conclusions:</strong> The results of these experiments demonstrate that the automated sample preparation capability of the TriPlus RSH SMART VOC Sample Prep Station coupled to the ISQ 7610 GC-MS system provides an ideal solution for water testing laboratories looking to improve productivity and deliver confident results.</p>
<ul>
<li>Static headspace is a convenient solventless extraction technique for volatiles in water with almost no sample preparation required. </li>
<li>Unattended operations of up to 210 samples can be achieved with the automated calibration dilution and ISTD addition workflows.</li>
<li>The automated addition of fresh reagent just before the incubation increases the stability of ISTD/surrogates mix, therefore improving the accuracy of the quantitation of target analytes during data reprocessing.</li>
<li>The TriPlus RSH SMART VOC Sample Prep Station ensures increased sample integrity for highly reliable quantitative analysis, and reduced errors or possible cross-contaminations, maximizing the productivity of the laboratory. Additionally, it allows saving valuable analyst time and improving safety by limiting the user’s exposure to toxic chemicals. </li>
<li>The integrated control for both autosampler and GC-MS in a single CDS ensures a streamlined automated workflow from on-line sample preparation to sequence setup, data acquisition, and reporting. </li>
<li>Suitability of headspace sampling for analysis of VOCs was demonstrated with R2  &gt; 0.990, RRF %RSD &lt; 20%, and calculated amount within 20% of the spiked concentration. </li>
<li>Inter-day reproducibility was demonstrated by running three batches of samples bracketed with QCs. Average absolute peak area %RSD across the entire evaluation period was &lt;20%, the QC calculated amount was within 20% of the expected value, and the calculated recovery was within 70–130%, with the only exception of 1,2-dibromo-3-chloropropane for which the % recovery was 132. </li>
<li>Reliable quantitative analysis was achieved for drinking water samples and surface water samples analyzed in three different batches across six working days. All the sample results were compliant with the thresholds set by the current EU regulation.</li>
</ul>


News from LabRulezGCMS Library - Week 30, 2024

<p><strong>Lithium-ion batteries (LIBs) have transformed energy storage technology, driving innovations for products we use in everyday life such as smartphones and even electric vehicles. But what makes these batteries so efficient? A key component is the electrolyte solution, a complex mix that’s crucial for battery performance. GC-MS or gas chromatography-mass spectrometry is an essential tool in analyzing these electrolyte mixtures and the development of increased efficiency and longer-lasting batteries.</strong></p><figure class="image"><img style="aspect-ratio:1024/551;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Electrifying_Insights_How_GC_MS_is_Powering_Lithium_Ion_Battery_Analysis_29d144ea28.jpg" alt="Thermo Fisher Scientific: Electrifying Insights: How GC-MS is Powering Lithium-Ion Battery Analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Electrifying_Insights_How_GC_MS_is_Powering_Lithium_Ion_Battery_Analysis_29d144ea28.jpg 245w," sizes="100vw" width="1024" height="551"></figure><h4><strong>Why Analyze Electrolytes?</strong></h4><p><strong>Electrolyte solutions are the essence of lithium-ion batteries, impacting:</strong></p><ul><li><strong>Performance</strong>: The right mix ensures faster charging and longer battery life.</li><li><strong>Safety</strong>: Accurate composition prevents overheating and potential hazards.</li><li><strong>Lifespan</strong>: Understanding degradation helps design components that last longer.</li></ul><p>Getting the electrolyte mix right is vital for efficient, safe, and durable batteries.</p><p><strong>However, analyzing electrolytes is complex and comes with a number of challenges:</strong></p><ol><li><strong>Complex Mixture</strong>: Electrolytes consist of various organic solvents, additives, and degradation products. This complexity requires sophisticated technology to separate and identify components.</li><li><strong>Heat Sensitivity</strong>: Components like LiPF6 can degrade at high temperatures, creating new compounds that complicate analysis.</li><li><strong>Trace Additives</strong>: Some additives are present in low concentrations but play a critical role in battery performance. Detecting these components demands highly sensitive methods.</li><li><strong>Degradation Products</strong>: Battery cycling produces byproducts that can interfere with the main components. It’s like trying to find a book in a disorganized library.</li></ol><p><strong>This is where GC-MS becomes an essential analytical tool. This powerful technique provides a detailed look into the composition of LIB electrolytes. The analysis follows a number of steps:</strong></p><ul><li><strong>Sample Prep</strong>: LIB electrolyte samples are diluted in dichloromethane and centrifuged to remove interfering salts.</li><li><strong>GC Separation</strong>: Samples are run through a gas chromatograph which uses a programmed temperature ramp ensures all components are separated within a 23-minute window.</li><li><strong>MS detection</strong>: After separation, the mass spectrometer operating in full scan and selected ion monitoring (SIM) provides detailed qualitative and quantitative data.</li></ul><p>Figure 1 shows the difference in selectivity between full scan and SIM mode. Vinylene carbonate is not detected in full scan at a 1 to 500 dilution due to the lack of selectivity and interference in full scan acquisition. However, by using SIM the ions of interest are isolated in the quadrupole increasing selectivity and allowing vinylene carbonate to be quantified at a low level.</p><figure class="image"><img style="aspect-ratio:881/694;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Electrifying_Insights_How_GC_MS_is_Powering_Lithium_Ion_Battery_Analysis_Figure_1_Full_scan_and_SIM_acquisition_of_vinylene_carbonate_in_cycled_LIB_electrolyte_at_1_500_dilution_6803793369.jpg" alt="Thermo Fisher Scientific: Figure 1. Full scan and SIM acquisition of vinylene carbonate in cycled LIB electrolyte at 1:500 dilution." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Electrifying_Insights_How_GC_MS_is_Powering_Lithium_Ion_Battery_Analysis_Figure_1_Full_scan_and_SIM_acquisition_of_vinylene_carbonate_in_cycled_LIB_electrolyte_at_1_500_dilution_6803793369.jpg 198w," sizes="100vw" width="881" height="694"></figure><p><strong>GC-MS brings several advantages to electrolyte analysis:</strong></p><ul><li><strong>Precise Separation</strong>: Achieves excellent separation of multiple components, ensuring accurate readings without co-elution issues.</li><li><strong>High Sensitivity</strong>: Detects even trace amounts of additives—down to 0.021 mg/L.</li><li><strong>Broad Range</strong>: Handles a wide concentration range, analyzing both major and minor components in one go.</li><li><strong>Degradation Insights</strong>: Reveals compositional shifts in cycled electrolytes, providing clues about the aging process of batteries.</li></ul><div><div><h4><strong>Why this analysis is important?</strong></h4><p>Understanding the detailed composition and changes in LIB electrolytes is crucial. It helps researchers and manufacturers fine-tune battery designs for enhanced performance, safety, and durability. While the analysis can be complex, the insights gained are invaluable.</p><p>So next time you charge your device remember the sophisticated science behind that battery. Tools like GC-MS are enabling battery technological advances to be made, ensuring the future of battery technology.</p><blockquote><p>For full details on this analysis<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_001124_gc_ms_isq_7610_li_battery_electrolyte_an001124_na_en_4df8612386/an-001124-gc-ms-isq-7610-li-battery-electrolyte-an001124-na-en.pdf"><strong>&nbsp;</strong></a><a target="_blank" rel="noreferrer noopener" aria-label="read the full application note. - open in a new tab" data-uw-rm-ext-link="" uw-rm-external-link-id="https://assets.thermofisher.com/tfs-assets/cmd/application-notes/an-001124-gc-ms-isq-7610-li-battery-electrolyte-an001124-na-en.pdf$readthefullapplicationnote."><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_001124_gc_ms_isq_7610_li_battery_electrolyte_an001124_na_en_4df8612386/an-001124-gc-ms-isq-7610-li-battery-electrolyte-an001124-na-en.pdf"><strong>read the full application note.</strong></a></a> For further details on how GC-MS can power your analysis, <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/gas-chromatography-mass-spectrometry-gc-ms/gc-ms-systems/single-quadrupole-gc-ms.html"><strong>visit our website.</strong></a></p><h5><strong>Visit us on </strong><a target="_blank" rel="noreferrer noopener" aria-label="LinkedIn: - open in a new tab" data-uw-rm-ext-link="" uw-rm-external-link-id="https://www.linkedin.com/showcase/72003132/admin/dashboard/$linkedin:"><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong>LinkedIn:</strong></a></a><strong> </strong>#LithiumIonBatteries #GCMS #BatteryMaterialAnalysis</h5><section><h4 data-uw-rm-heading="level" role="heading" aria-level="2"><strong>Adam Ladak</strong></h4><div itemprop="description">Adam Ladak is the global product marketing manager for GC quadrupole mass spectrometry at Thermo Fisher, based in the UK. He started his career working in a contracting testing lab analyzing sports supplements and horse feed for prohibited substances. He has over 20 years of experience in the analytical testing industry and has worked for leading instrument manufacturers in various roles from an application specialist to a global marketing role focused on food and environmental testing. Adam is passionate about utilizing our GCMS instrumentation to meet the customer needs and solve real world problems.</div></section></blockquote></div></div>

Electrifying Insights: How GC-MS is Powering Lithium-Ion Battery Analysis

<p><strong>As you embark on your festive celebrations, clinking glasses filled with delightful brews, have you ever considered the meticulous science behind that perfect sip? At Creature Comforts Brewing Co., ensuring each sip of your favorite drink, be it their seasonal festive IPA or my favorite the bold Flash Cat imperial IPA, tastes just right is a year-round commitment.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_The_Joy_of_Festive_Drinks_A_Cheerful_Tale_of_Consistency_2a360b32e9.jpeg" alt="Thermo Fisher Scientific: The Joy of Festive Drinks: A Cheerful Tale of Consistency." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_The_Joy_of_Festive_Drinks_A_Cheerful_Tale_of_Consistency_2a360b32e9.jpeg 245w," sizes="100vw" width="1024" height="512"></p><p>Nestled in Athens, Georgia, Creature Comforts has become a beacon of quality in the craft beer community since its inception in 2014. Their success lies not just in innovative brewing, but in an unwavering focus on consistency. For this they use an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/484"><strong>advanced Gas chromatography mass spectrometry or GC-MS system</strong></a>. This instrument is a crucial tool in the brewery’s lab that ensures every batch of beer is <strong>consistent </strong>and meets the <strong>highest standards</strong>.</p><p>At Creature Comforts, an array of tests are performed which include checking for <strong>alcohol content, pH levels, density</strong>, and <strong>microbiological tests </strong>to ensure no beer-spoiling organisms are present. Among the most critical tests is the daily check of<strong> vicinal diketones</strong> (VDKs), compounds that can impart off-flavors if not properly controlled. The GC-MS system excels at performing these tests swiftly and accurately. The <strong>GC-MS</strong> system is also utilized for experimental trials, testing how variations in ingredients or processes might affect the final product.</p><p>In-house testing using such advanced equipment allows for rapid issue resolution and ensures that production rates remain high without sacrificing quality. By keeping sample handling within a controlled environment, contamination is avoided, and testing accuracy is maintained. Adding another layer of quality assurance is their sensory panel, a group of trained tasters who subject each batch to rigorous tasting sessions. This panel functions like Santa’s little helpers, making sure only the best brews make it to your holiday celebrations. Any batch that doesn’t meet their expectations is promptly held back for further adjustments.</p><p>So, this festive season, as you enjoy a glass of your favorite holiday beer, take a moment to appreciate the dedication and precision that goes into each sip. Behind every beer, lies a commitment to quality and consistency that makes your celebrations a bit more special. Here’s to the craft brewers who ensure our festive drinks are always delightful, maintaining the joy and cheer of the season, one sip at a time. Happy holidays and cheers to consistent quality!</p><blockquote><p>For more insights into the dedication and science behind Creature Comforts’ brewing process, check out the <a target="_blank" rel="noopener" aria-label="full case study - open in a new tab" data-uw-rm-ext-link="" uw-rm-external-link-id="https://assets.thermofisher.com/tfs-assets/cmd/reference-materials/cs-000433-gc-ms-flavors-volatiles-beer-cs000433-en.pdf$fullcasestudy"><a target="_blank" rel="noopener noreferrer" href="https://assets.thermofisher.com/TFS-Assets/CMD/Reference-Materials/cs-000433-gc-ms-flavors-volatiles-beer-cs000433-en.pdf"><strong>full case study</strong></a></a>.</p><p><strong>Visit our&nbsp;</strong><a target="_blank" rel="noreferrer noopener" aria-label="LinkedIn page - open in a new tab" data-uw-rm-ext-link="" uw-rm-external-link-id="https://www.linkedin.com/showcase/chromatography-&amp;-mass-spectrometry/posts/?feedview=all$linkedinpage"><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/chromatography-&amp;-mass-spectrometry/posts/?feedView=all"><strong>LinkedIn page</strong></a></a><strong>:</strong> #GCMS #QC</p></blockquote><section><blockquote><h4 data-uw-rm-heading="level" role="heading" aria-level="2"><strong>Adam Ladak</strong></h4><div itemprop="description">Adam Ladak is the global product marketing manager for GC quadrupole mass spectrometry at Thermo Fisher, based in the UK. He started his career working in a contracting testing lab analyzing sports supplements and horse feed for prohibited substances. He has over 20 years of experience in the analytical testing industry and has worked for leading instrument manufacturers in various roles from an application specialist to a global marketing role focused on food and environmental testing. Adam is passionate about utilizing our GCMS instrumentation to meet the customer needs and solve real world problems.</div></blockquote></section>

The Joy of Festive Drinks: A Cheerful Tale of Consistency

<p><strong>Polycyclic aromatic hydrocarbons (PAHs) are a group of organic compounds with two or more fused aromatic rings. They are found in fossil fuels and are produced by the incomplete combustion of organic matter, making them ubiquitous in the environment. Due to their potential toxic effects, including carcinogenicity and endocrine disruption, PAHs are closely monitored in the environment, especially in soil and water samples.&nbsp;</strong></p><p>However, the analysis of PAHs in environmental samples presents several challenges, particularly when adhering to stringent regulatory requirements such as the <strong>U.S. EPA Method 8270E1</strong>. In this blog, we will explore these challenges and how advanced GC-MS technology can be utilized to address and overcome these challenges.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Tackling_PAH_Analysis_in_Environmental_Samples_Overcoming_the_Challenges_with_Advanced_GC_MS_Technology_8ba846d208.jpg" alt="Thermo Fisher Scientific: Tackling PAH Analysis in Environmental Samples - Overcoming the Challenges with Advanced GC-MS Technology." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Tackling_PAH_Analysis_in_Environmental_Samples_Overcoming_the_Challenges_with_Advanced_GC_MS_Technology_8ba846d208.jpg 245w," sizes="100vw" width="1024" height="576"></p><h3 id="h-challenges-in-pah-analysis" data-uw-rm-heading="level" role="heading" aria-level="2"><strong>Challenges in PAH Analysis</strong></h3><h4 id="h-1-regulatory-compliance" data-uw-rm-heading="level" role="heading" aria-level="3"><strong>1. Regulatory Compliance</strong></h4><p>Compliance with <strong>EPA Method 8270E</strong> requires specific tuning and calibration procedures. For instance, the method mandates the use of DFTPP (Decafluorotriphenylphosphine) tuning to ensure ion abundances are within acceptable limits. Additionally, maintaining consistent instrument performance over extended runs without maintenance is crucial to meet regulatory standards and ensure results are reported in a timely manner.</p><h4 id="h-2-complex-sample-matrix"><strong>2. Complex Sample Matrix</strong></h4><p>Environmental samples including soil and wastewater are complex matrices and contain interference that can affect the accurate detection and quantification of PAHs. The presence of isobaric compounds necessitates high chromatographic resolution to distinguish between closely eluting PAH compounds, such as benzo[b]fluoranthene and benzo[k]fluoranthene.</p><h4 id="h-3-wide-range-of-detection-levels"><strong>3. Wide Range of Detection Levels</strong></h4><p>PAH analysis must cover a wide range of detection levels across different matrices, from low parts-per-billion (ppb) to high parts-per-million (ppm) concentrations. This diversity necessitates a versatile analytical method capable of maintaining accuracy and precision across a broad dynamic range. Creating and managing multiple calibration curves for different concentration ranges and matrices can be time-consuming and prone to errors.</p><h3 id="h-overcoming-the-challenges-of-pah-analysis-in-environmental-samples"><strong>Overcoming the Challenges of PAH Analysis in Environmental Samples</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Tackling_PAH_Analysis_in_Environmental_Samples_Overcoming_the_Challenges_with_Advanced_GC_MS_Technology_2_e03ef1d953.jpg" alt="Thermo Fisher Scientific: Figure 1: Chromatographic separation and peak shape for 19 investigated PAHs, 5 labelled ISTD and 2 Surrogate standards in a solvent standard at 0.1 ppm acquired in SIM. Tracks of the quantification ions are reported for each peak in different colors. 1=Naphthalene-d8, 2=Naphthalene, 3=2-methyl Naphthalene, 4=1-methyl Naphthalene, 5=Acenaphthylene, 6=Acenaphthene, 7=Acenaphtene-d10 , 8=Dibenzofuran, 9=Fluorene, 10=Tribromophenol 2,4,6, 11=Phenantrene-d10 , 12=Phenantrene, 13=Anthracene, 14=Fluoranthene, 15=Terphenyl-d14, 16=Pyrene, 17=Benz[a]anthracene, 18=Chrysene-d12, 19=Chrysene 20=Benzo[b]fluoranthene, 21=Benzo[k]fluoranthene, 22=Benzo[a]pyrene, 23=Perylene-d12, 24=Dibenzo[a,h]anthracene, 25=Indeno[1,2,3-cd] pyrene, 26=Benzo[g,h,i]perylene" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Tackling_PAH_Analysis_in_Environmental_Samples_Overcoming_the_Challenges_with_Advanced_GC_MS_Technology_2_e03ef1d953.jpg 245w," sizes="100vw" width="1024" height="552"></p><p>A PAH analysis method was fully optimized on the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/484"><strong>Thermo Scientific ISQ 7610 single quadrupole GC-MS system</strong></a>, equipped with the XLXR detector to overcome these challenges. For more information on the methods details and extensive data from the analysis you can review the full application note. The highlights of the benefits of using this GC-MS system include:</p><h4 id="h-1-wide-dynamic-range"><strong>1. Wide Dynamic Range</strong></h4><p>The XLXR detector offers an extended linear dynamic range and during this study over four orders of magnitude <strong>(2.5 ppb to 20 ppm)</strong> were covered for the <strong>19 PAHs </strong>analyzed. This wide dynamic range eliminates the need for separate calibration curves for different concentration ranges, simplifying the workflow and reducing the potential for errors.</p><p>Using a single calibration curve for multiple matrices, such as soil and water, offers significant advantages:</p><ul><li><strong>Simplified Workflow</strong>: A single calibration curve across a wide dynamic range streamlines the analytical process, reducing the time and effort required to prepare and manage multiple curves.</li><li><strong>Increased Throughput</strong>: By eliminating the need for separate curves, laboratories can analyze more samples in less time, enhancing productivity and reducing turnaround times.</li><li><strong>Improved Accuracy</strong>: Combined calibration curves minimize the potential for calibration errors, ensuring consistent and reliable quantification across different sample types.</li><li><strong>Versatility Across Matrices</strong>: The ability to use a single calibration curve for different matrices (e.g., soil and water) enhances the versatility of the analytical method, making it easier to adapt to various environmental sample types without compromising accuracy.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Tackling_PAH_Analysis_in_Environmental_Samples_Overcoming_the_Challenges_with_Advanced_GC_MS_Technology_3_3_539d6ad458.jpg" alt="Thermo Fisher Scientific: Figure 2: Examples of Average Response Factor calibration curve for some of the 19 PAHs analyzed, (from left to right: Naphthalene, Dibenzofuran, Phenantrene, Fluoranthene, Benzo[b]fluoranthene), Benzo[g,h,i]perylene, annotated with the %RSD. Linearity spans over 5 orders of magnitudes, from 2.5 to 20000 ng/mL." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Tackling_PAH_Analysis_in_Environmental_Samples_Overcoming_the_Challenges_with_Advanced_GC_MS_Technology_3_3_539d6ad458.jpg 245w," sizes="100vw" width="1024" height="640"></p><h4 id="h-2-sensitivity"><strong>2. Sensitivity</strong></h4><p>The system demonstrates excellent sensitivity with low instrument detection limits (IDLs) and method detection limits (MDLs) in the low picogram range. These detection limits exceed regulatory requirements, ensuring that even trace levels of PAHs are accurately quantified, providing reliable data for environmental monitoring.</p><h4 id="h-3-robustness"><strong>3. Robustness</strong></h4><p>The GCMS system maintained consistent sensitivity and peak shape over extended runs, with no significant performance degradation after 136 injections or 52 hours of continuous operation. This robustness is crucial for continuous operation of the system, allowing laboratories to run samples over an entire weekend without user intervention. This ensures high throughput and maximizes productivity.</p><h3 id="h-conclusion"><strong>Conclusion</strong></h3><p>The <strong>Thermo Scientific ISQ 7610 GC-MS</strong> system provides a comprehensive solution to the challenges of PAH analysis in environmental samples. Its advanced features, including a wide dynamic range, excellent sensitivity, and robust performance, ensure compliance with EPA Method 8270E and improved laboratory efficiency. By leveraging the benefits of combined calibration curves, laboratories can achieve accurate, reliable, and high-throughput PAH analysis.</p><blockquote><p>For more detailed information on the capabilities of this advanced GC-MS system, please visit the <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/gas-chromatography-mass-spectrometry-gc-ms/gc-ms-systems/single-quadrupole-gc-ms.html">ISQ 7610 GC-MS product page</a>.</p><article aria-label="Tackling PAH Analysis in Environmental Samples: Overcoming the Challenges with Advanced GC-MS Technology"><div><p><strong>Visit our&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/chromatography-&amp;-mass-spectrometry/posts/?feedView=all"><strong>LinkedIn page</strong></a><strong>: </strong>#PAHAnalysis #EnvironmentalMonitoring #GCMS</p></div></article><section><h4><strong>Adam Ladak</strong></h4><div itemprop="description">Adam Ladak is the global product marketing manager for GC quadrupole mass spectrometry at Thermo Fisher, based in the UK. He started his career working in a contracting testing lab analyzing sports supplements and horse feed for prohibited substances. He has over 20 years of experience in the analytical testing industry and has worked for leading instrument manufacturers in various roles from an application specialist to a global marketing role focused on food and environmental testing. Adam is passionate about utilizing our GCMS instrumentation to meet the customer needs and solve real world problems.</div></section></blockquote>

Tackling PAH Analysis in Environmental Samples: Overcoming the Challenges with Advanced GC-MS Technology

Article

Product

Events

Webinars

Application

Academy

Video

Poster

Scientists

Plastics

Environment

Food

Water

Health

Presentation

Scientific article

Interview

Toxicology

Popularization

Science and research

Software

Covid-19

Career

Laboratories

Various

Zaměření

Type of News

Focus

A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

Thermo Fisher Scientific

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

Tackling PAH Analysis in Environmental Samples: Overcoming the Challenges with Advanced GC-MS Technology

The Joy of Festive Drinks: A Cheerful Tale of Consistency

Electrifying Insights: How GC-MS is Powering Lithium-Ion Battery Analysis

News from LabRulezGCMS Library - Week 30, 2024

Upcoming events

LECO Training Course Pegasus HRT+ / HRT+ 4D

Agilent Lab Innovation Day for Academia

Thermal Analysis Online Trainings 2026 - TGA-GC/MS

Webinars

The Journey of Safer Science through Safer Labs

Column Confidence: Making the Right Choice for Your GC Needs

Measure smarter, spend less – NIR spectroscopy for polymer analysis