GCMS
More information
WebinarsAbout usContact usTerms of use
LabRulez s.r.o. All rights reserved. Content available under a CC BY-SA 4.0 Attribution-ShareAlike
Author
LabRulez
LabRulez
Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.
Tags
Article
Product
LinkedIn Logo

Single Quadrupole Mass Detectors (SQ) in GC/MS

Th, 4.9.2025
| Original article from: LabRulezGCMS Bazaar
Explore Agilent GC/MS single quadrupole detectors and accessories. Refurbished systems, analyzers, and EI sources for reliable trace analysis across industries.
<p>LabRulez / AI: Single Quadrupole Mass Detectors (SQ) in GC/MS</p>

LabRulez / AI: Single Quadrupole Mass Detectors (SQ) in GC/MS

Gas chromatography coupled with mass spectrometry (GC/MS) is one of the most widely used analytical techniques for the separation, identification, and quantification of volatile and semi-volatile compounds. At the heart of most benchtop GC/MS systems lies the single quadrupole (SQ) mass detector, also known as a mass selective detector (MSD).

What is a Single Quadrupole Detector?

A quadrupole mass spectrometer consists of four precisely aligned metal rods that create oscillating electric fields. Ions generated in the ion source are filtered by the quadrupole depending on their mass-to-charge ratio (m/z). Only ions of a selected m/z value reach the detector at any given time, enabling selective ion monitoring (SIM) as well as full scan acquisition.

Main Components of a SQ GC/MSD

  • Ion Source – commonly electron ionization (EI) or chemical ionization (CI), where analyte molecules are ionized.
  • Quadrupole Mass Filter – four rods generating alternating RF/DC voltages, allowing passage of ions with a specific m/z.
  • Detector – typically an electron multiplier that amplifies ion signals into measurable currents.
  • Vacuum System – turbomolecular and roughing pumps that maintain high vacuum for ion transmission.
  • Electronics & Control – power supplies, RF/DC generators, and data system software.

Advantages of Single Quadrupole Detectors

  • Robustness and reliability – decades of proven performance in routine laboratories.
  • High sensitivity – suitable for trace analysis in complex matrices.
  • Versatility – applicable across environmental, food safety, pharmaceutical, petrochemical, and forensic fields.
  • Ease of use – streamlined hardware design with wide support for software and service.
  • Cost efficiency – more affordable compared to high-resolution or tandem mass spectrometry systems.

Typical Applications

  • Environmental analysis (e.g., VOCs, pesticides, dioxins)
  • Food safety (residues, contaminants, flavors)
  • Pharmaceutical QC and impurity profiling
  • Petrochemical characterization
  • Forensic and toxicological investigations

Available Bazaar Systems and Accessories

1. Agilent 5977 GC/MS System (Refurbished)

Reliable, versatile GC/MS system designed for environmental, food, chemical, petrochemical, and forensic applications. Combines advanced GC and MS technologies for high sensitivity.

2. Agilent 5975 (G3171A) Mass Spectrometer (Refurbished)

Robust GC/MSD with high precision and reliability, widely used in environmental, food safety, pharma, and forensic labs.

LabRulez : Agilent 5975 (G3171A) Mass SpectrometerLabRulez : Agilent 5975 (G3171A) Mass Spectrometer

3. Agilent 5973 GC/MS System (Refurbished)

Versatile system offering sensitivity, reliability, and flexibility for a wide application range.

4. Agilent 5977B HES Analyzer, G7077-67797 (Tested)

Replacement analyzer assembly with High-Efficiency Source (HES) for Agilent 5977B GC/MSD. Increases sensitivity for trace analysis.

5. Agilent 5977 EI Extraction Analyzer, G7077-69201 (Tested)

Analyzer assembly designed for electron ionization (EI) in Agilent 5977 systems.

6. Agilent Electron Ionization (EI) Extraction Source Assembly, G3870-67720 (New)

EI source assembly for Agilent 5977 and 7000 series GC/MS systems.

7. Agilent 7890A/5975C GC/MSD (G3440A/G3174A) (Refurbished)

Configured system with 7890A GC and 5975C MSD plus GC PAL autosampler.

LabRulez: Agilent 7890A/5975C GC/MSD (G3440A/G3174A)LabRulez: Agilent 7890A/5975C GC/MSD (G3440A/G3174A)

8. Agilent 6890N/5973N GC/MSD System (SSL, PTV, FID) (Refurbished)

Advanced GC/MSD system with multiple inlets (SSL, PTV), detectors (FID, MSD). Designed for complex matrices in environmental, pharma, and petrochemical labs.

9. Agilent GC/MSD (6850/5975B) Purge and Trap System (Refurbished)

Special configuration of 6850 GC and 5975B MSD with purge and trap for volatile organic compound analysis.

LabRulez: Agilent GC/MSD (6850/5975B) Purge and Trap SystemLabRulez: Agilent GC/MSD (6850/5975B) Purge and Trap System

LabRulez
LinkedIn Logo
 

Related content

Analysis of Aroma Components in Apples Using the Smart Aroma Database

Applications
| 2026 | Shimadzu
Instrumentation
GC/MSD, GC/SQ, HeadSpace
Manufacturer
Shimadzu
Industries
Food & Agriculture

Analysis of Acetaldehyde and Limonene in Recycled PET Using an HS-GCMS System (Carrier Gas: H2)

Applications
| 2026 | Shimadzu
Instrumentation
GC/MSD, GC/SQ, HeadSpace
Manufacturer
Shimadzu
Industries
Energy & Chemicals

What Causes GC Capillary Column Performance Degradation, and How Can I Prevent It?

Technical notes
| 2026 | Agilent Technologies
Instrumentation
Consumables, GC columns
Manufacturer
Agilent Technologies
Industries
Other

Aromatic Component Analysis of Gasoline According to ASTM D5580 Using the Brevis GC- 2050 Gas Chromatograph

Applications
| 2025 | Shimadzu
Instrumentation
GC
Manufacturer
Shimadzu
Industries
Energy & Chemicals

Micro GC Analysis of Permanent Gas Impurities in PEM Fuel Cell-Grade Hydrogen

Applications
| 2025 | Agilent Technologies
Instrumentation
GC
Manufacturer
Agilent Technologies
Industries
Energy & Chemicals
 

Related articles

Webinars LabRulezGCMS Week 07/2026
Article | Webinars

Webinars LabRulezGCMS Week 07/2026

3 webinars: AI in manufacturing, fermentation, functional food, mAb production, metabolite monitoring, process Raman, process analytics
LabRulez
tag
share
more
QuEChERS Combined with Low-Temperature Partitioning and GC–MS as an Analytical Strategy for the Determination of Multiclass Pesticide Residues in Cocoa Beans
Scientific article | Science and research

QuEChERS Combined with Low-Temperature Partitioning and GC–MS as an Analytical Strategy for the Determination of Multiclass Pesticide Residues in Cocoa Beans

This study combines QuEChERS and low-temperature partitioning with GC–MS to determine multiclass pesticide residues in cocoa beans with good sensitivity and recoveries.
LabRulez
tag
share
more
ISC 2026 Short Course 3 - Interpretation of Mass Spectra: Basic Introduction for Chromatographers
Article | Events

ISC 2026 Short Course 3 - Interpretation of Mass Spectra: Basic Introduction for Chromatographers

Short Course 3 at ISC 2026 offers a practical introduction to LC–MS spectral interpretation for chromatographers, covering ESI, APCI, APPI, adducts, isotope patterns, and MS/MS fundamentals.
International Symposium on Chromatography - (ISC)
tag
share
more
Eurachem/CITAC Workshop on Quality in Analytical Measurements 2026
Article | Events

Eurachem/CITAC Workshop on Quality in Analytical Measurements 2026

Eurachem Week 2026 brings training and workshops on measurement uncertainty, quality in analytical measurements, and results interpretation, combining theory, practical cases, and expert-led discussions.
Eurachem
tag
share
more
 

Related content

Analysis of Aroma Components in Apples Using the Smart Aroma Database

Applications
| 2026 | Shimadzu
Instrumentation
GC/MSD, GC/SQ, HeadSpace
Manufacturer
Shimadzu
Industries
Food & Agriculture

Analysis of Acetaldehyde and Limonene in Recycled PET Using an HS-GCMS System (Carrier Gas: H2)

Applications
| 2026 | Shimadzu
Instrumentation
GC/MSD, GC/SQ, HeadSpace
Manufacturer
Shimadzu
Industries
Energy & Chemicals

What Causes GC Capillary Column Performance Degradation, and How Can I Prevent It?

Technical notes
| 2026 | Agilent Technologies
Instrumentation
Consumables, GC columns
Manufacturer
Agilent Technologies
Industries
Other

Aromatic Component Analysis of Gasoline According to ASTM D5580 Using the Brevis GC- 2050 Gas Chromatograph

Applications
| 2025 | Shimadzu
Instrumentation
GC
Manufacturer
Shimadzu
Industries
Energy & Chemicals

Micro GC Analysis of Permanent Gas Impurities in PEM Fuel Cell-Grade Hydrogen

Applications
| 2025 | Agilent Technologies
Instrumentation
GC
Manufacturer
Agilent Technologies
Industries
Energy & Chemicals
 

Related articles

Webinars LabRulezGCMS Week 07/2026
Article | Webinars

Webinars LabRulezGCMS Week 07/2026

3 webinars: AI in manufacturing, fermentation, functional food, mAb production, metabolite monitoring, process Raman, process analytics
LabRulez
tag
share
more
QuEChERS Combined with Low-Temperature Partitioning and GC–MS as an Analytical Strategy for the Determination of Multiclass Pesticide Residues in Cocoa Beans
Scientific article | Science and research

QuEChERS Combined with Low-Temperature Partitioning and GC–MS as an Analytical Strategy for the Determination of Multiclass Pesticide Residues in Cocoa Beans

This study combines QuEChERS and low-temperature partitioning with GC–MS to determine multiclass pesticide residues in cocoa beans with good sensitivity and recoveries.
LabRulez
tag
share
more
ISC 2026 Short Course 3 - Interpretation of Mass Spectra: Basic Introduction for Chromatographers
Article | Events

ISC 2026 Short Course 3 - Interpretation of Mass Spectra: Basic Introduction for Chromatographers

Short Course 3 at ISC 2026 offers a practical introduction to LC–MS spectral interpretation for chromatographers, covering ESI, APCI, APPI, adducts, isotope patterns, and MS/MS fundamentals.
International Symposium on Chromatography - (ISC)
tag
share
more
Eurachem/CITAC Workshop on Quality in Analytical Measurements 2026
Article | Events

Eurachem/CITAC Workshop on Quality in Analytical Measurements 2026

Eurachem Week 2026 brings training and workshops on measurement uncertainty, quality in analytical measurements, and results interpretation, combining theory, practical cases, and expert-led discussions.
Eurachem
tag
share
more
 

Related content

Analysis of Aroma Components in Apples Using the Smart Aroma Database

Applications
| 2026 | Shimadzu
Instrumentation
GC/MSD, GC/SQ, HeadSpace
Manufacturer
Shimadzu
Industries
Food & Agriculture

Analysis of Acetaldehyde and Limonene in Recycled PET Using an HS-GCMS System (Carrier Gas: H2)

Applications
| 2026 | Shimadzu
Instrumentation
GC/MSD, GC/SQ, HeadSpace
Manufacturer
Shimadzu
Industries
Energy & Chemicals

What Causes GC Capillary Column Performance Degradation, and How Can I Prevent It?

Technical notes
| 2026 | Agilent Technologies
Instrumentation
Consumables, GC columns
Manufacturer
Agilent Technologies
Industries
Other

Aromatic Component Analysis of Gasoline According to ASTM D5580 Using the Brevis GC- 2050 Gas Chromatograph

Applications
| 2025 | Shimadzu
Instrumentation
GC
Manufacturer
Shimadzu
Industries
Energy & Chemicals

Micro GC Analysis of Permanent Gas Impurities in PEM Fuel Cell-Grade Hydrogen

Applications
| 2025 | Agilent Technologies
Instrumentation
GC
Manufacturer
Agilent Technologies
Industries
Energy & Chemicals
 

Related articles

Webinars LabRulezGCMS Week 07/2026
Article | Webinars

Webinars LabRulezGCMS Week 07/2026

3 webinars: AI in manufacturing, fermentation, functional food, mAb production, metabolite monitoring, process Raman, process analytics
LabRulez
tag
share
more
QuEChERS Combined with Low-Temperature Partitioning and GC–MS as an Analytical Strategy for the Determination of Multiclass Pesticide Residues in Cocoa Beans
Scientific article | Science and research

QuEChERS Combined with Low-Temperature Partitioning and GC–MS as an Analytical Strategy for the Determination of Multiclass Pesticide Residues in Cocoa Beans

This study combines QuEChERS and low-temperature partitioning with GC–MS to determine multiclass pesticide residues in cocoa beans with good sensitivity and recoveries.
LabRulez
tag
share
more
ISC 2026 Short Course 3 - Interpretation of Mass Spectra: Basic Introduction for Chromatographers
Article | Events

ISC 2026 Short Course 3 - Interpretation of Mass Spectra: Basic Introduction for Chromatographers

Short Course 3 at ISC 2026 offers a practical introduction to LC–MS spectral interpretation for chromatographers, covering ESI, APCI, APPI, adducts, isotope patterns, and MS/MS fundamentals.
International Symposium on Chromatography - (ISC)
tag
share
more
Eurachem/CITAC Workshop on Quality in Analytical Measurements 2026
Article | Events

Eurachem/CITAC Workshop on Quality in Analytical Measurements 2026

Eurachem Week 2026 brings training and workshops on measurement uncertainty, quality in analytical measurements, and results interpretation, combining theory, practical cases, and expert-led discussions.
Eurachem
tag
share
more
 

Related content

Analysis of Aroma Components in Apples Using the Smart Aroma Database

Applications
| 2026 | Shimadzu
Instrumentation
GC/MSD, GC/SQ, HeadSpace
Manufacturer
Shimadzu
Industries
Food & Agriculture

Analysis of Acetaldehyde and Limonene in Recycled PET Using an HS-GCMS System (Carrier Gas: H2)

Applications
| 2026 | Shimadzu
Instrumentation
GC/MSD, GC/SQ, HeadSpace
Manufacturer
Shimadzu
Industries
Energy & Chemicals

What Causes GC Capillary Column Performance Degradation, and How Can I Prevent It?

Technical notes
| 2026 | Agilent Technologies
Instrumentation
Consumables, GC columns
Manufacturer
Agilent Technologies
Industries
Other

Aromatic Component Analysis of Gasoline According to ASTM D5580 Using the Brevis GC- 2050 Gas Chromatograph

Applications
| 2025 | Shimadzu
Instrumentation
GC
Manufacturer
Shimadzu
Industries
Energy & Chemicals

Micro GC Analysis of Permanent Gas Impurities in PEM Fuel Cell-Grade Hydrogen

Applications
| 2025 | Agilent Technologies
Instrumentation
GC
Manufacturer
Agilent Technologies
Industries
Energy & Chemicals
 

Related articles

Webinars LabRulezGCMS Week 07/2026
Article | Webinars

Webinars LabRulezGCMS Week 07/2026

3 webinars: AI in manufacturing, fermentation, functional food, mAb production, metabolite monitoring, process Raman, process analytics
LabRulez
tag
share
more
QuEChERS Combined with Low-Temperature Partitioning and GC–MS as an Analytical Strategy for the Determination of Multiclass Pesticide Residues in Cocoa Beans
Scientific article | Science and research

QuEChERS Combined with Low-Temperature Partitioning and GC–MS as an Analytical Strategy for the Determination of Multiclass Pesticide Residues in Cocoa Beans

This study combines QuEChERS and low-temperature partitioning with GC–MS to determine multiclass pesticide residues in cocoa beans with good sensitivity and recoveries.
LabRulez
tag
share
more
ISC 2026 Short Course 3 - Interpretation of Mass Spectra: Basic Introduction for Chromatographers
Article | Events

ISC 2026 Short Course 3 - Interpretation of Mass Spectra: Basic Introduction for Chromatographers

Short Course 3 at ISC 2026 offers a practical introduction to LC–MS spectral interpretation for chromatographers, covering ESI, APCI, APPI, adducts, isotope patterns, and MS/MS fundamentals.
International Symposium on Chromatography - (ISC)
tag
share
more
Eurachem/CITAC Workshop on Quality in Analytical Measurements 2026
Article | Events

Eurachem/CITAC Workshop on Quality in Analytical Measurements 2026

Eurachem Week 2026 brings training and workshops on measurement uncertainty, quality in analytical measurements, and results interpretation, combining theory, practical cases, and expert-led discussions.
Eurachem
tag
share
more
Other projects
LCMS
ICPMS
Follow us
More information
WebinarsAbout usContact usTerms of use
LabRulez s.r.o. All rights reserved. Content available under a CC BY-SA 4.0 Attribution-ShareAlike