News from LabRulezGCMS Library - Week 33, 2024

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 12th August 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!

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This week we bring to you a poster from ASMS 2024 by LECO, applications and other documents by Agilent Technologies, and Shimadzu!

1. LECO: Employing Novel Sample Preparation and Analysis by GC-TOFMS for Improved Target and Non-Target Detection of Leachables in Cream/Gel Drug Products

• poster / ASMS 2024

Introduction: Topical ointments are commonly used to treat diseases and skin conditions by introducing the active drug ingredient through the dermis. To ensure the safety of the product for consumers, the US FDA requires that these formulations undergo leachables studies to determine the presence of chemicals which may migrate into the product from the packaging materials. Topical ointments such as creams and gels often take the form of oil-in-water emulsions which presents a challenging matrix for these analyses. Since these emulsions cannot be analyzed directly, novel sample preparations must be developed. Even with improved sample preparation techniques, the resulting extracts can still be challenging for traditional GC-MS systems. In this collaborative study, two different sample preparation methods were employed to extract a group of five chemicals commonly found in metal packaging containers such as tubes and tins. Unspiked and blind spiked samples from extraction methods A and B were provided for analysis on LECO’s Pegasus® BTX GC-Time-of-Flight (TOF) MS system. The goal was to determine the ability of the system to effectively detect and identify these chemicals with a non-target approach by leveraging mass spectral deconvolution and a software tool (ChromaTOF® Sync) designed for the comparison of samples.

Conclusions

• The Pegasus BTX GC-TOFMS successfully detected and identified all five spiked leachables in this non-target case study. Non-target analyses can be critically important for extractable and leachable studies to ensure drug product safety.
• ChromaTOF Sync was used to successfully compare unspiked and blind-spiked ointment extracts to quickly find the leachable analytes which were present at significantly higher levels in the spikes. Automated deconvolution was crucial for uncovering the spiked analytes from the complex matrix interferences.
• A brief demonstration of GCxGC separation power to improve the trace level identification of 9,10-anthracenedione in the presence of heavy matrix background was effectively demonstrated.

2. Agilent Technologies: Analysis of Residual N-Methyl-2-Pyrrolidone (NMP) in Lithium-Ion Battery Electrodes

• Application

An analysis approach using the Agilent 8697 headspace sampler with the Agilent 8860 GC system and flame ionization detector

Abstract: Accurately measuring N-methyl-2-pyrrolidone (NMP) residue is crucial for ensuring appropriate control of electrode quality in lithium-ion battery manufacturing. This necessitates the extraction of residual NMP from battery electrodes for subsequent gas chromatography (GC) analysis. Two common extraction approaches include liquid extraction (LE) of NMP from electrodes and heated extraction through a headspace sampler. This application note describes an NMP analysis method using headspace-based extraction and GC analysis with a flame ionization detector (FID). Residual NMP analysis was then conducted on real electrode samples to compare the results between headspace sampling (HS) and LE techniques.

Conclusion: In this study, a method for analyzing residual NMP in electrodes was developed using the Agilent 8697 headspacesampler coupled with the Agilent 8860 GC system and FID. The method's investigation assessed the system's performance in terms of matrix-matched calibration, quantitation precision, detection limit, and system carryover. The HS approach demonstrated an excellent detection limit and quantitation precision for targeted NMP analysis. In the carryover test, no NMP was detected in the blank run immediately after analyzing a blank cathode spiked with 100 µg NMP. The comparison between HS and LE analytical methods showed that HS could accurately quantify NMP in anode samples. The recovery rate of NMP from cathodes using the HS technique was approximately 65 to 78% of that achieved by the LE-based method. Given its operational simplicity and quantitation precision, HS is suitable for the process control of an established electrodes manufacturing route, while LE is recommended for the development of manufacturing processes and troubleshooting electrode quality issues.

3. Agilent Technologies: Get the Most from Your MS Agilent J&W DB-5Q and HP-5Q GC columns

• Other

Agilent J&W DB-5Q and HP-5Q GC columns

Meet the new gold standard for GC/MS

Agilent J&W 5Q GC columns are designed to ensure optimal analyte delivery to your quadrupoles. They combine industry-leading ultra inert performance with ultra low-bleed technology, setting a new standard for GC/MS column reliability and productivity.

• Ultra low-bleed performance enhances data accuracy with high spectral fidelity and stable baseline integration.
• Ultra inert performance increases sensitivity for active, trace-level analytes and provides balanced deactivation for multiclass analyte panels.
• Ultrafast conditioning and outstanding column durability improve uptime by minimizing the frequency of column changes.
• Identical selectivity to current 5ms columns simplifies adaptation to existing retention time libraries and retention time locking.
• Compatibility with any GC/MS system ensures a seamless fit for all Agilent GC platforms.

4. Shimadzu: GC/GC-MS Glass Insert/Liner Selection Guide

• Guides

Contents

1. Introduction

• 1-1. Glass Inserts/Liners 3
• 1-2. Sample Injection Unit/Injection Method 4

2. Glass Insert Selection

• 2-1. Glass Insert Selection by GC Model/Sample Injection Unit
  • GC-2030/GC-2050
  • GC-2010 series
  • GC-2014 series
  • GC-2025
  • HS-10
• 2-2. Glass Insert Selection by Application
  • SPME/SPME Arrow
  • Aqueous Solvent Analysis
  • SPL (Split/Splitless)

3. Selection Guide

4. All Glass Insert List

• 4-1. Glass Insert Compatible Instruments
• 4-2. Glass Insert Information Table

5. Accessories