<p><strong>The choice between micro-Snyder column concentration and </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=362&amp;manufacturerItems=540"><strong>nitrogen blowdown evaporation</strong></a><strong> represents one of the most critical decisions in EPA analytical methodology. Both techniques serve as validated concentration methods across numerous EPA test procedures, yet each offers distinct advantages that make them suitable for different analytical scenarios. Understanding these differences is essential for laboratories seeking to optimize their analytical workflows and ensure regulatory compliance.</strong></p><h3><strong>Understanding the Fundamentals</strong></h3><p>Both concentration techniques serve the same primary purpose: reducing extract volumes to levels suitable for instrumental analysis while maintaining analyte integrity. However, their operational principles differ significantly in terms of temperature requirements, operator involvement, and equipment specifications.</p><p>The micro-Snyder column technique utilizes controlled heat application through a hot water bath maintained at 60-65°C, with the distillation process regulated by the column's three-ball or two-ball design [1, 2]. The technique provides visual indicators of proper operation through actively chattering balls, which signal optimal distillation rates without chamber flooding [2]. In contrast, nitrogen blowdown operates at significantly lower temperatures of 30-35°C, using a gentle stream of filtered nitrogen to facilitate solvent evaporation [3, 4].</p><h3><strong>Widespread EPA Method Applications</strong></h3><h4><strong>Micro-Snyder Column Integration</strong></h4><p>The micro-Snyder column technique demonstrates remarkable ubiquity across EPA analytical methods, appearing as a standard procedure in numerous applications:</p><ul><li><strong>Water Analysis: EPA Method 625</strong> for base/neutral and acid extraction specifies the use of both three-ball macro-Snyder columns for initial concentration (15-20 minutes) and two-ball micro-Snyder columns for final concentration (5-10 minutes) [2]. The method requires pre-wetting columns with 0.5 mL of methylene chloride and maintaining proper distillation rates where "the balls of the column will actively chatter but the chambers will not flood with condensed solvent" [2].</li><li><strong>Organochlorine Analysis: EPA Method 610</strong> for polynuclear aromatic hydrocarbons incorporates micro-Snyder columns for both standard concentration and specialized solvent exchange procedures, including acetonitrile concentration at elevated temperatures of 95-100°C [5].</li><li><strong>Nitrosamine Detection:</strong> <strong>EPA Method 607</strong> utilizes micro-Snyder columns as part of its comprehensive extraction and concentration protocol, with specific volume adjustments to 2.0 mL following concentration [6].</li><li><strong>Advanced Extraction Methods:</strong> <strong>EPA Method 3570</strong> for microscale solvent extraction employs sequential micro-Snyder columns, using both three-ball and two-ball columns in series for optimal concentration control [1].</li></ul><h4><strong>Nitrogen Blowdown Applications</strong></h4><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/5392"><strong>Nitrogen blowdown evaporation </strong></a>has gained significant acceptance across EPA methodologies, particularly for applications requiring gentle thermal treatment:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/what-is-solid-phase-extraction-spe"><strong>Solid Phase Extraction</strong></a><strong>: EPA Method 3535A</strong> explicitly provides nitrogen evaporation as an alternative to micro-Snyder column concentration, recognizing both techniques as equally valid approaches. The method specifies operation in a warm water bath at 30°C with filtered nitrogen that has passed through activated carbon [3].</li><li><strong>Environmental Monitoring: EPA Method 1668</strong> for chlorinated biphenyl congeners incorporates nitrogen blowdown for micro-concentration procedures, utilizing water bath temperatures between 30-60°C . The method emphasizes the importance of controlled evaporation to prevent analyte degradation.</li><li><strong>Pesticide Analysis: EPA Method 1699</strong> for pesticides in environmental matrices specifies nitrogen blowdown procedures with water bath temperatures of 60°C, demonstrating the technique's versatility across different temperature ranges [7].</li><li><strong>PFAS Analysis:</strong> Modern EPA methods for per- and polyfluoroalkyl substances (PFAS), including <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/concentrating-pfas-samples-ahead-of-lcms"><strong>Methods 533 and 537.1</strong></a>, rely heavily on nitrogen blowdown due to the thermal sensitivity of these emerging contaminants [8].</li></ul><h3><strong>Comparative Performance Analysis</strong></h3><h4><strong>Micro-Snyder Column Advantages</strong></h4><ul><li><strong>Standardized Reproducibility:</strong> The micro-Snyder column technique offers inherent standardization through its visual feedback mechanism. The actively chattering balls provide immediate indication of proper operation, reducing operator variability between laboratories [2]. This standardization has contributed to its widespread adoption across EPA methods spanning decades of regulatory use.</li><li><strong>Built-in Safety Features:</strong> The column design incorporates multiple safety elements, including automatic regulation of distillation rates and the 10-minute cooling and draining period that prevents rapid temperature changes [2]. These features minimize the risk of analyte loss due to operator error or equipment malfunction.</li><li><strong>Proven Regulatory Acceptance: </strong>The technique's inclusion in foundational EPA methods like 625, 610, and 607 demonstrates its long-standing regulatory acceptance and proven reliability across diverse analytical applications [2, 5, 6].</li><li><strong>Efficient Heat Transfer: </strong>The controlled temperature environment of 60-65°C provides efficient solvent evaporation while remaining below the degradation threshold for most organic compounds [1, 2].</li></ul><h4><strong>Nitrogen Blowdown Advantages</strong></h4><ul><li><strong>Temperature-Sensitive Analyte Preservation:</strong> Operating at 30-35°C, nitrogen blowdown provides gentler thermal treatment that preserves heat-sensitive compounds [3, 4]. This advantage is particularly crucial for emerging contaminants like PFAS, where thermal degradation can significantly impact analytical results [8].</li><li><strong>Precise Volume Control: </strong>The technique allows operators to achieve exact final volumes through visual monitoring, stopping evaporation at precisely the desired endpoint . This precision is valuable when specific concentration factors are required for regulatory compliance.</li><li><strong>Reduced Equipment Investment:</strong> Nitrogen blowdown requires minimal specialized glassware compared to <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1904"><strong>Kuderna-Danish</strong></a> apparatus with Snyder columns, making it accessible for laboratories with limited capital budgets [9].</li><li><strong>Enhanced Operator Control: </strong>The real-time monitoring capability allows operators to adjust evaporation rates and respond to unexpected conditions during the concentration process [9].</li></ul><h4><strong>Comparative Limitations</strong></h4><ul><li><strong>Micro-Snyder Column Challenges: </strong>The technique requires significant capital investment in specialized glassware and heating equipment [2]. Additionally, the automated nature of the process provides limited operator control once concentration begins, potentially problematic for samples requiring specific handling.</li><li><strong>Nitrogen Blowdown Limitations: </strong>The technique demands constant operator attention to prevent over-concentration, with organophosphorus pesticides being particularly susceptible to losses from complete dryness. Contamination risks from plastic tubing and the need for precise nitrogen flow control add complexity to routine operations [3].</li></ul><h3><strong>Method Selection Guidelines</strong></h3><h4><strong>Sample Throughput Considerations</strong></h4><p>High-volume environmental laboratories often favor micro-Snyder columns for their automated operation and reduced hands-on time requirements [2]. The technique allows multiple samples to be processed simultaneously with minimal operator intervention, improving laboratory productivity.</p><p>Conversely, laboratories processing smaller sample batches or requiring individual sample optimization may prefer <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1908"><strong>nitrogen blowdown's flexibility</strong></a> and precise control capabilities [9].</p><h4><strong>Analyte-Specific Requirements</strong></h4><p>Temperature-sensitive compounds, including many pharmaceutical residues and emerging contaminants, benefit from nitrogen blowdown's lower operating temperatures [8, 9]. The 30-35°C operating range significantly reduces thermal stress compared to the 60-65°C requirement for micro-Snyder columns [3].</p><p>For thermally stable environmental pollutants like polynuclear aromatic hydrocarbons and organochlorine compounds, both techniques provide equivalent performance with method selection based on operational preferences [5].</p><h4><strong>Regulatory Compliance Factors</strong></h4><p>Specific EPA methods may designate one technique over another, eliminating choice for particular analytical procedures. However, methods like EPA 3535A that offer both options allow laboratories to select based on their specific capabilities and quality control requirements [3].</p><h4><strong>Contemporary Applications and Future Trends</strong></h4><p>The analytical landscape continues evolving with emerging contaminants and advanced instrumentation. Nitrogen blowdown has gained particular prominence in PFAS analysis due to these compounds' thermal sensitivity and the need for trace-level detection [8]. This trend reflects the technique's adaptability to modern analytical challenges.</p><p>Simultaneously, micro-Snyder columns remain essential for established environmental monitoring programs where long-term data consistency requires standardized procedures [2]. The technique's proven track record supports its continued use in regulatory compliance monitoring.</p><h3><strong>Conclusion</strong></h3><p>Both micro-Snyder column concentration and nitrogen blowdown serve critical roles in EPA analytical methodology, with optimal selection depending on specific analytical requirements, laboratory capabilities, and regulatory constraints. The micro-Snyder column technique excels in standardized, high-throughput applications where proven reliability and regulatory acceptance are paramount. Nitrogen blowdown provides superior performance for temperature-sensitive analytes and applications requiring precise volume control.</p><p>Modern laboratories benefit from understanding both techniques' capabilities, allowing method selection based on analyte properties, sample characteristics, and operational requirements. As analytical chemistry continues advancing with new contaminants and detection challenges, both concentration methods will remain valuable tools in the environmental analyst's toolkit.</p><p>The choice between these techniques ultimately reflects the broader analytical strategy, balancing regulatory compliance, analytical performance, and operational efficiency to achieve reliable environmental monitoring results.</p>

Micro-Snyder Column vs Nitrogen Blowdown: Choosing the Right Concentration Method for EPA Applications

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 1st June 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you brochure by <strong>Agilent Technologies</strong>, application note by<strong> Shimadzu, </strong>and<strong> </strong>presentation by <strong>MDCW / University of Washington!</strong></p><h3><strong>1. Agilent Technologies: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B"><strong>Agilent 8890B Gas Chromatograph</strong></a></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ds_8890_gas_chromatograph_5994_9064en_agilent_94b0175782.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>The Agilent 8890B GC delivers high‑performance gas chromatography through advanced electronic pneumatic control, precise oven temperature management, and Agilent capillary flow technology, which provides reliable, leak‑free, in‑oven connections and supports flexible system configurations with minimal method development time.&nbsp;</p><p>An upgrade, more responsive 7-inch capacitive touchscreen and a full Agilent GC Assist interface, offer real-time status, configuration, signal monitoring, and remote access for setup, troubleshooting, leak checking, maintenance, and method management across devices.&nbsp;</p><p>Sustainability features include programmable sleep and wake modes to reduce resource consumption, along with gas and power usage calculators that track method‑level efficiency. Known for reliability and long life, Agilent GC systems are supported by a 10‑year use guarantee to ensure a low cost of ownership.</p><h4><strong>GC system capabilities&nbsp;</strong></h4><ul><li><strong>Retention time repeatability: </strong>&lt; 0.008% or &lt; 0.0008 minutes&nbsp;</li><li><strong>Area repeatability:</strong> &lt; 0.5% RSD&nbsp;</li></ul><p>Built-in intelligence autonomously monitors the health of the system, alerts the user of potential issues before they affect chromatographic performance, and offers helpful step-by-step guides to resolve issues.&nbsp;</p><p>The 7-inch touch screen gives a visual report of the system configuration, letting you update the active method, perform maintenance routines, and check GC instrument status.&nbsp;</p><p>The GC Assist interface provides remote connectivity enabling you to monitor your smart GC system, check system logs, and perform diagnostics tests, from inside or outside the&nbsp;laboratory.&nbsp;</p><p>Maintenance and service modes, including autonomous leak checks, are easily accessed from the touchscreen and browser interface.&nbsp;</p><p>Atmospheric pressure and temperature compensation are built into every system, so results do not change, even when the laboratory environment does.</p><p>Automatic liquid sampling is fully integrated into mainframe control and includes up to 3-layer sandwich injections and sample preparation capabilities such as heating, mixing, standard addition, and derivatizations.&nbsp;</p><h5><strong>Simultaneously supports&nbsp;</strong></h5><ul><li>Two inlets&nbsp;</li><li>Five detectors&nbsp;</li><li>Four detectors (with additional large valve oven&nbsp;option)&nbsp;</li><li>Support for up to 10 valves&nbsp;</li><li>Six GC column Smart Key ports&nbsp;</li></ul><h5><strong>Instrument dimensions&nbsp;</strong></h5><ul><li><strong>Height: </strong>49 cm (19.2 in)&nbsp;</li><li><strong>Width: </strong>58 cm (22.9 in) with EPC inlet and detectors; 68&nbsp;cm (26.8 in) with detector as TCD or with certain valving options mounted on the left side of the GC&nbsp;</li><li><strong>Depth: </strong>51 cm (20.2 in)&nbsp;</li><li><strong>Typical weight:</strong> 49 kg (108 lb)&nbsp;</li></ul><h5><strong>Maintenance and support services&nbsp;</strong></h5><ul><li>Integrated early maintenance counters that allow planned maintenance and help eliminate unnecessary downtime&nbsp;</li><li>Instrument events or shutdowns displayed on keyboard display or data system</li><li>Remote diagnostics&nbsp;</li><li>Performance verification services&nbsp;</li><li>Easy parts identification and part number finder software (standalone software, does not require Agilent CDS)</li></ul></div></div></div></div></div></div></section><h3><strong>2. MDCW / University of Washington: Tile-based Analysis of GC×GC-TOFMS Data of SPME Sampled VOCs Produced from Pseudomonas aeruginosa and Aspergillus fumigatus</strong></h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_8_Wenjing_34786a3e4a.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>This presentation describes a novel chemometric approach for analyzing complex GC×GC-TOFMS datasets generated from volatile organic compounds (VOCs) released by the pathogens <i>Pseudomonas aeruginosa</i> and <i>Aspergillus fumigatus</i>. These microorganisms frequently coexist in the lungs of cystic fibrosis patients, where their interactions are associated with worsening respiratory function and poorer clinical outcomes. The study aims to identify VOC biomarkers that distinguish microbial monocultures, cocultures, and growth media controls, providing insights into pathogen interactions and potential diagnostic markers.</p><p>To achieve this, the researchers combined solid-phase microextraction (SPME) sampling with comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37"><strong>GC×GC-TOFMS</strong></a>). This analytical platform offers high chromatographic resolution, rapid spectral acquisition rates of up to 500 spectra per second, and rich three-dimensional datasets containing chromatographic and mass spectral information. However, each chromatogram can contain more than one million data points, creating significant challenges for data processing and interpretation.</p><p>The core of the work focuses on tile-based feature selection methods implemented through the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/348"><strong>ChromaTOF Tile software</strong></a>. The primary approach, tile-based Fisher Ratio (F-ratio) analysis, identifies analytes that differ statistically between sample classes by comparing between-class and within-class variance. Using this strategy, the authors discovered 576 VOC features capable of differentiating growth media, <i>P. aeruginosa</i> monocultures, <i>A. fumigatus</i> monocultures, and cocultures. Additional pairwise statistical testing was then used to determine which specific classes were responsible for the observed differences. Representative VOCs characteristic of each class were identified, including heptanal for <i>P. aeruginosa</i>, 1-octen-3-ol for <i>A. fumigatus</i>, and several unique compounds associated with coculture conditions.</p><p>The presentation also addresses practical challenges associated with high-throughput experimentation, where replicate measurements may be limited by time, cost, or sample availability. To overcome these constraints, the team developed complementary tile-based coefficient of variation (CV) and fold-change (FC) approaches that can identify important analytes using as little as a single replicate per sample class. The authors conclude that selecting the appropriate feature-selection strategy—F-ratio, CV, or fold-change—depends on the experimental design and available data. Future work will focus on advanced analyte identification using chemometric tools such as PARAFAC, enabling deeper biological interpretation of microbial VOC signatures and their relevance to cystic fibrosis research.</p><h3><strong>3. Shimadzu: Alcohol Determination of Sanitizer Gel Using </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexis+GC-2060"><strong>Nexis GC-2060</strong></a></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01120_en_ed83896803.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>The newly developed FID on the Nexis GC-2060 provides excellent linearity for high-concentration samples.</li><li>The Nexis GC-2060 enables rapid oven heating and cooling, allowing results to be obtained quickly.</li><li>A special liner for aqueous solutions and an Xtra Life Microsyringe enable highly repeatable data acquisition</li></ul><p>Methods for alcohol determination are specified in USP (United States Pharmacopeia) General Chapters &lt;611&gt; ALCOHOL DETERMINATION, which describes both a distillation and a gas chromatography method. In USP &lt;611&gt;, Method II (gas chromatography) includes a capillary column method (Method IIb).&nbsp;</p><p>For GC analysis of samples containing a large amount of water (e.g., sanitizing ethanol), sample vaporization may become unstable, resulting in abnormal peak shapes and poor repeatability. In addition, with a standard micro-syringe for AOC, the plunger may become stiff during aspiration and dispensing of aqueoussolutions, which can degrade repeatability.&nbsp;</p><p>This article presents an example of alcohol determination in sanitizing ethanol using the Nexis GC-2060 equipped with a newly developed FID. The Nexis GC-2060 can be configured with a newly developed FID that has high sensitivity and excellent linearity. In addition, a special liner for aqueous solutions and an Xtra Life Microsyringe were used to achieve repeatable analysis.</p><h5><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexis+GC-2060"><strong>Nexis GC-2060</strong></a><strong> and the Newly Developed FID</strong></h5><p>The Nexis GC-2060 is a gas chromatograph that combines world-class analytical performance with workflow optimization based on the latest technologies. Rapid oven heating and cooling shorten analysis cycle time and improve throughput. The GC-2060 can also be equipped with a newly developed FID (Fig. 1). This FID offers world-class sensitivity and improved linearity.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The alcohol concentration in a commercially available sanitizing gel was determined using the Nexis GC-2060 equipped with the newly developed FID. The results met the system suitability requirements of USP &lt;611&gt; Method IIb, confirming the effectiveness of the Nexis GC2060 equipped with the new FID, along with the special liner for aqueous solutions, and the Xtra Life Microsyringe for repeatable analysis of aqueoussamples</p></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 23, 2026

<p><strong>Two-in-one — this is one way to describe a new material developed by an international team of scientists including researchers from the Centre for Energy and Environmental Technologies at VSB – Technical University of Ostrava (CEET) and CATRIN at Palacký University. This versatile material, based on iron and carbon atoms, can not only convert plastic waste into useful products, but also reduce the cost of manufacturing important chemicals and pharmaceuticals. The researchers recently published their findings in the prestigious journal Nature Catalysis and are now planning to scale up production to a pilot-plant level.</strong></p><p>The scientists set out to help address one of today’s most pressing challenges: plastic recycling. They focused on polystyrene, global production of which exceeds 20 million tonnes annually, while only a negligible fraction – approximately one to three percent – is currently recycled. Existing recycling methods are either inefficient or technologically complex and environmentally unfriendly.</p><p>“<i>Mechanical recycling of polystyrene leads to deterioration in product quality and limits its further applications. Pyrolysis is energy-intensive, requires very high temperatures, and the resulting chemical mixture must be purified through complex processes. That is why we developed an environmentally friendly low-temperature technology which, with the help of oxygen and ammonia, enables the production of benzonitrile. This is a highly valuable chemical used as a key building block in the production of pharmaceuticals, fertilizers, and other industrial chemicals,</i>” said <strong>Radek Zbořil</strong>, one of the lead authors of the study affiliated with CEET and CATRIN.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Smart_Material_Enables_Efficient_Plastic_Recycling_and_Low_Cost_Drug_Manufacturing_754bc72c0c.webp" alt="CATRIN: Smart Material Enables Efficient Plastic Recycling and Low-Cost Drug Manufacturing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Smart_Material_Enables_Efficient_Plastic_Recycling_and_Low_Cost_Drug_Manufacturing_754bc72c0c.webp 245w," sizes="100vw" width="1536" height="768"></p><p>However, converting polystyrene and other organic compounds into nitriles is highly challenging because their chemical bonds are stable and difficult to break. The key to success was therefore the development of an efficient catalyst capable of lowering reaction temperatures while increasing the yield of the target product.</p><p>“<i>The catalyst is based on iron atoms dispersed within a carbon support and stabilized by nitrogen and boron atoms. This specific chemical environment surrounding the atomic iron, together with the porous structure of the support, is essential for achieving efficient low-temperature conversion of polystyrene. The material can be easily produced on a large scale and, once the chemical process is completed, it can be recycled and reused. These factors are crucial for the advancement of industrial processes,</i>” explained <strong>Jagadeesh Rajenahally</strong>, another <strong>corresponding author</strong> affiliated with CEET and the Leibniz Institute for Catalysis in Rostock, Germany.</p><p>The applications of the new catalyst extend far beyond polystyrene. It can also efficiently convert dozens of organic compounds into valuable nitriles used in chemistry and pharmaceuticals, for example in the production of antidepressants and diabetes medications. Its versatility, ease of production, lower energy consumption, and the significant cost reduction it offers for many chemical processes are expected to accelerate its adoption in industry. The scientists are therefore planning to scale up production to a pilot operation.</p><p>“<i>The atomic catalyst is remarkably versatile. We successfully used it in the synthesis of around 60 valuable nitrile-based chemicals utilized in pharmaceuticals and industrial chemistry. We operate at significantly lower temperatures than current industrial production methods, and thanks to the controlled reaction pathway, we generate only minimal amounts of waste by-products. In a flow reactor, we demonstrated the material’s stability over many days during polystyrene conversion, which are very promising results for transferring the technology into practical applications,</i>” Zbořil concluded.</p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41929-026-01513-y#Sec9"><strong>Iron-based single-atom catalysts for selective ammoxidation of C(sp3)–H bonds and oxidative C–C cleavage reactions</strong></a></h4><p>Zhuang Ma (马壮), Nils Rockstroh, Zupeng Chen (陈祖鹏), Vishakha Goyal, Chakreshwara Kuloor, Stephan Bartling, Zdeněk Baďura, Jabor Rabeah, Lin Dong (董琳), Henrik Lund, Bing Nan (南兵), Radek Zbořil, Rajenahally V. Jagadeesh &amp; Matthias Beller</p><p>Nat Catal 9, 389–403 (2026)</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41929-026-01513-y">https://doi.org/10.1038/s41929-026-01513-y</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><p><strong>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.</strong></p><div><h4><strong>Abstract</strong></h4><p>Ammoxidation of methylarenes using ammonia and air is the main method for the synthesis of aromatic nitriles in the chemical industry. Despite significant efforts in industry and academia, no general and selective catalyst based on less toxic and earth-abundant metals has been developed for this reaction. Here we report a single-atom iron-based material (Fe@BNC-800-L1) with Fe–N<sub>5</sub>–B<i><sub>x</sub></i> configuration as an efficient <i>sp</i><sup>3</sup>-hybridized C–H- and C–C bond oxidation catalyst. Due to the presence of Fe<sup>3+</sup>, B and N species, which are co-embedded in the micro-mesoporous carbon matrix, these materials show excellent activity for ammoxidation of methyl-substituted (hetero)arenes. Furthermore, highly selective C–C bond cleavage reactions of alkylarenes are presented, which complement the toolbox for nitrile synthesis. The generality of this presented Fe-based ammoxidation methodology is showcased by the straightforward and selective synthesis of &gt;60 functionalized and structurally diverse nitriles, which are important precursors and key intermediates in organic synthesis with many applications in life sciences and industry.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Graphical_abstract_85dcee4b26.webp" alt="Nat Catal 9, 389–403 (2026): Graphical abstract" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Graphical_abstract_85dcee4b26.webp 227w," sizes="100vw" width="685" height="471"></p><h4><strong>Methods</strong></h4><h5><strong>General procedure for the synthesis of nitriles from methyl and alkyl (hetero) arenes</strong></h5><p>Unless otherwise stated catalytic reactions of all substrates were performed with following procedure: a magnetic stirring bar, 0.5 mmol methylarene or alkylarene or lignin model compound and 50 mg Fe@BNC-800-L1 (2.46 mol% Fe) were transferred to an 8 ml glass vial. Next, 3 ml deionized water and 100 μl NH<sub>3</sub>(aq. 28–30%) were added and the vial was fitted with a septum, cap and needle. The reaction vials (8 vials each containing different substrates) were placed into a 300 ml autoclave. The autoclave was flushed with nitrogen (10 bar) twice and molecular oxygen (5 bar) twice and then it was pressurized with 5 bar oxygen. The autoclave was placed into an aluminium block preheated at 150 °C and the reactions were stirred for the required time. After the completion of the reactions, the autoclave was cooled to room temperature. The remaining oxygen was discharged and the vials containing the reaction products were removed from the autoclave. The solid catalyst was filtered off and washed thoroughly with ethyl acetate. Products in the filtrate were extracted with ethyl acetate and analysed using GC and GC-MS. The corresponding nitriles were purified by column chromatography. For selected products, yields were determined by GC. For GC analysis, the filtrate containing the products was extracted with ethyl acetate. To this ethyl acetate solution containing products, <i>n</i>-hexadecane (0.5 mmol) as a standard was added and then the products were analysed using GC. To confirm experimental reproducibility, all catalytic reactions including benchmark reactions and substrate scope evaluations, were performed at least two to three times to ensure reproducibility. The yields and selectivity data reported in the manuscript represent the average of these independent experiments. For example, the ammoxidation of 4-methylanisole (benchmark reaction) yielded 75 ± 3% in three independent experiments. Undoubtedly, safety aspects are of high importance in ammoxidations involving ammonia and oxygen in the reaction system. All catalytic reactions were carried out in a Parr autoclave equipped with an explosion-proof device and the autoclave was placed in a well-ventilated fume hood to conduct the reactions. After the reaction was completed, the autoclave was carefully removed and placed in an ice bath to cool down, and then the gases were slowly released. Further details of the procedure are provided in the <a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41929-026-01513-y#MOESM1">Supplementary Information</a>.</p><p>Due to low the boiling points of substrates <strong>5</strong>, <strong>9</strong>, <strong>13</strong>, <strong>28</strong>, <strong>29</strong>, <strong>30</strong>, <strong>44</strong> and <strong>62</strong>, their catalytic reactions were performed individually in a glass-fitted 25 ml autoclave. The experimental procedure for these reactions is as follows: a magnetic stirring bar, 0.5 mmol methylarene or alkylarene and 50 mg Fe@BNC-800-L1 (2.46 mol% Fe) were transferred to a 25 ml autoclave (run one sample at a time). Next, 5 ml deionized water and 100 µl NH<sub>3</sub>(aq. 28–30%) were added. The autoclave was sealed and flushed with nitrogen (10 bar) twice and molecular oxygen (5 bar) twice and then it was pressurized with 5 bar oxygen. The autoclave was placed into an aluminium block preheated at 150 °C and the reactions were stirred for the required time. After the completion of the reactions, the autoclave was cooled to room temperature. The remaining oxygen was discharged and reaction products were removed from the autoclave. The solid catalyst was filtered off and washed thoroughly with ethyl acetate. The mixture was extracted with ethyl acetate and <i>n</i>-hexadecane as a standard was added. Finally, the products were analysed using GC and GC-MS. The corresponding nitriles were purified by column chromatography. For selected products, yields were determined by GC using the same procedure (see above).</p></div>

Smart Material Enables Efficient Plastic Recycling and Low-Cost Drug Manufacturing

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The Czech Advanced Technology and Research Institute (CATRIN) at Palacký University is a cutting-edge scientific hub dedicated to advancing research in the fields of nanotechnology, biotechnology, and biomedicine. At its core, CATRIN boasts outstanding scientific teams, featuring international researchers. We emphasize interdisciplinarity, foster global collaborations, and work to translate our research findings into practical applications.

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>High-performance plastics (polymers) are the backbone of modern aerospace, medical, analytical instrumentation, and energy technologies. Because they are designed to survive extreme heat and chemicals, they are notoriously difficult to break down and study. To build better materials and ensure they don’t fail, scientists need to understand their chemical composition including the additives and “building blocks” that give them their strength.</strong></p><p>This webinar demonstrates two specialized sample delivery techniques to characterize these materials without the need for elaborate sample preparation strategies:</p><ul><li><strong>Thermal Desorption: </strong>Controlled heating (up to 300 °C) of the plastic to release additives and potential contaminants.</li><li><strong>Pyrolysis: </strong>Using intense heat (greater than 600 °C) to break the plastic’s “backbone” into identifiable fragments.</li></ul><p>Combining these techniques with high-resolution GC-TOFMS enables detection of the complex chemical fingerprints for high-performance plastics like polyether ether ketone (PEEK, used in medical implants) and polytetrafluoroethylene (PTFE, commonly known as Teflon).</p><p>We will demonstrate a reliable method to analyze the chemistry of the world’s toughest plastics. This method will help manufacturers ensure their materials are pure, and ready for use in planes, electronics, and human bodies.</p><blockquote><p><strong>Presenter: </strong>David Alonso (Applications Chemist, LECO Corporation)</p></blockquote></div></div></div>

LECO: Characterization of High-Performance Polymers Using Thermal Desorption/Pyrolysis and High-Resolution Mass Spectrometry 

Characterization of High-Performance Polymers Using Thermal Desorption/Pyrolysis and High-Resolution Mass Spectrometry 

Advanced GC-TOFMS workflows using thermal desorption and pyrolysis for chemical characterization of high-performance plastics like PEEK and PTFE.

Polymer characterization by TD/Pyrolysis & HRMS

<p><strong>Spatially offset Raman spectroscopy (SORS), provides a powerful and non-destructive approach for identifying materials without opening packages or containers. However, measurement success depends strongly on sample characteristics, container materials, and testing conditions. This webinar presents an experience-based overview of what SORS-enabled Raman spectroscopy can and cannot reliably measure using the Agilent Vaya Raman spectrometer as a representative platform. We will discuss classes of materials that are Raman-inactive or weak, samples prone to fluorescence or low signal, and common container materials that interfere with or block Raman measurements. Practical guidance will be provided on container thickness, color, and composition, as well as when black shielding or ambient light control is required. The session will help users quickly assess feasibility, set realistic expectations, and determine when Raman—or an alternative technique such as FTIR—is the appropriate analytical choice.</strong></p><blockquote><p><strong>Presenter: </strong>Yanqia Wang, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)</p><p>Dr. Yanqia Wang started working for Agilent Technologies Inc. as a FTIR application Engineer in 2013, providing pre-&amp;post-sale application support. The products he covers from Bench-top FTIR microscopes to various Mobile FTIR spectrometers. Dr. Wang received his PhD of analytical chemistry from Duke University in 2004, doing dynamic IR spectroscopy research. Then he joined Fitzpatrick Center for Photonics at Duke University, doing Tissue Raman spectrometer instrumentation. Since 2007, Dr. Wang worked for Avery Dennison Corp. as a spectroscopist, providing molecular analytical support to the research &amp; development.</p></blockquote>

Agilent Technologies: Molecular spectroscopy webinars

Seeing Through the Barrier: Practical Limits and Best Practices for Raman Sample, Container, and Test Conditions

Webinar on SORS Raman feasibility with Agilent Vaya. Learn limits, container effects, fluorescence challenges, and when FTIR is the better alternative.

Practical Limits and Best Practices for Raman

<h3><strong>Real-Time Process Insights for Oil, Gas, &amp; Future Fuels with Raman Spectroscopy</strong></h3><h4><strong>A 5-Part Webinar Series</strong></h4><p>As the energy sector shifts toward more complex and dynamic processes, real-time analytics are essential for maintaining control, efficiency, and product quality. This 5-part webinar series explores how process Raman spectroscopy and integrated measurement solutions enable fast, in-line analysis across oil &amp; gas, power generation, and emerging energy applications.</p><h5><strong>What we'll cover:</strong></h5><p>Each session highlights practical approaches to improving process visibility, reducing analytical delays, and supporting faster decision-making for:</p><ul><li>Natural gas</li><li>Refined fuels</li><li>Hydrogen</li><li>Sustainable aviation fuels</li><li>Carbon capture</li><li>Power generation</li><li>Emerging energy applications</li></ul><h5><strong>This Series is Ideal For:</strong></h5><p>Process, operations, and instrumentation professionals across oil &amp; gas, power generation, and emerging energy sectors, including engineers, plant and refinery managers, and technical specialists involved in process optimization and analytical measurement.</p><h5><strong>Join the Webinars To:</strong></h5><ul><li>Understand how real-time, in-line analytics improve process control and efficiency</li><li>Learn how process Raman simplifies and accelerates gas and liquid analysis</li><li>Explore alternatives to traditional methods such as gas chromatography</li><li>See how integrated measurement solutions enhance operational visibility</li><li>Gain insight into applications across conventional and next-generation energy systems</li></ul><h4><strong>Webinar 4: Direct In-Line Fuel &amp; Lubricant Quality Monitoring with Process Raman</strong></h4><p>Ensuring refined fuels and lubricants stay on spec is critical - and direct in-line measurement provides the confidence needed to maintain control throughout production. This webinar explores how a Process Raman Analyzer enables true direct in-line measurement of refined fuels and related products, including diesel, gasoline, jet fuel, and lubricants.</p><p>We’ll share real-world examples of monitoring essential properties such as API gravity, RON, RVP, cetane, and flash point - all aligned with ASTM methods. Unlike other technologies, Process Raman requires no sample conditioning system and eliminates consumables or carrier gases, reducing complexity and costs while delivering continuous, non-destructive analysis.</p><p>With its small footprint and hazardous-location rating, Process Raman integrates seamlessly into production environments - providing operators with peace of mind through reliable, uninterrupted monitoring and immediate detection of deviations. The result: tighter process control, consistent product quality, and lower operating costs.</p><h5><strong>Process Raman Enables:</strong></h5><ul><li>Immediate detection of deviations for faster corrective action</li><li>Lower maintenance and operating costs</li><li>A streamlined path to compliance and consistent quality</li></ul><blockquote><p><strong>Speaker: </strong>Janam Pandya (Product Manager - Measurement Control and Sample Identification, Thermo Fisher Scientific)</p><p><strong>Speaker:</strong> Tom Dearing (Product Manager for Chemometrics, NIR, and Gas Analysis, Thermo Fisher Scientific)</p></blockquote>

Thermo Fisher Scientific: Real-Time Process Insights for Oil, Gas, & Future Fuels with Raman Spectroscopy

Direct In-Line Fuel & Lubricant Quality Monitoring with Process Raman

Discover how Process Raman analyzers support real-time fuel and lubricant quality monitoring with direct in-line analysis and reduced operational complexity.

Direct In-Line Fuel & Lubricant Process Raman Monitoring

<h4><strong>How Transformative New Software Solutions Are Elevating Quality and Compliance</strong></h4><p>As organizations navigate the challenges of increasing efficiency and productivity without compromising quality or compliance, new software solutions are emerging that enable labs to reduce risk with vigilant monitoring, ensure precision, and uphold the highest standards of compliance. By streamlining processes, reducing error and downtime, and providing real-time insights, these innovations not only improve operational efficiency but also help laboratories meet stringent regulatory requirements for quality management maturity. Join us to uncover how embracing these innovations can make our lives better and safer by fostering a culture of accountability, quality improvement, and sustainable compliance.</p><h5><br><strong>Agenda includes</strong></h5><ul><li><strong>Introduction</strong></li><li><strong>Regulation Meets Innovation | Waters Data Strategy in the Cloud</strong><ul><li>Mario Rossi- Informatics Market Development Director</li></ul></li><li><strong>Innovative Software Tool Demonstration</strong><ul><li>Jason Loftus- Pr. Informatics Business Development Specialist</li></ul></li></ul><blockquote><p><strong>Speaker: </strong>Jason Loftus (Senior Informatics Sales Development Specialist, Waters Corporation)</p><p>After getting his BS in Chemistry, Jason worked as a QC Chemist for a consumer products company in Massachusetts. In 1998, he joined Waters as a Field Service Engineer based in Boston, MA. In 2001, he left Waters to join a biopharma company in Colorado, but returned to Waters in 2004 as a Field Service Engineer covering the southwestern US. In 2010, he became the Service Manager for the Mountain Region covering most of the western US. In 2016, he joined the Informatics Sales Development team and currently covers the western US, western Canada, and the southeastern US.</p><p><strong>Moderator:</strong> Mario S. Rossi, PE (Enterprise Informatics Market Development Director, Waters Corporation)</p><p>Mario has over 20 years of experience in the pharmaceutical life sciences industry, with deep expertise in laboratory informatics. In his current role, he leads strategic initiatives to expand and accelerate the adoption of Waters enterprise informatics solutions, including Empower Enterprise, NuGenesis LMS, waters_connect network, and Waters’ cloud-based applications. Since joining Waters in 2004, Mario has held a variety of leadership roles across technical presales, business development, and informatics sales. Prior to Waters, he served as an engineer at New Brunswick Scientific and Wallace &amp; Tiernan. Mario holds an MBA in Marketing and a BS in Electrical Engineering from the University of South Florida. He is also a licensed Professional Engineer in the State of New Jersey.</p></blockquote>

How Transformative New Software Solutions Are Elevating Quality and Compliance

Explore new laboratory software solutions and cloud data strategies. Reduce risk, ensure precision, and meet strict regulatory compliance requirements

New Software Solutions for Quality & Compliance

<p><strong>Part 1: Technology Overview – How V-ITEX Enhances Headspace Analysis</strong></p><p>In this first webinar of the V-ITEX Webinar Series, Thomas Albinus from GERSTEL and Stefan Cretnik from CTC Analytics provide a focused introduction to the technical principles behind Vacuum In-Tube Extraction.</p><p>The session explains how V-ITEX uses controlled vacuum, dynamic sorption, and direct transfer to the GC-MS system to improve the extraction and enrichment of volatile compounds.<br>Participants will learn how the technique enables gentle VOC extraction from complex and temperature-sensitive samples without heating, while supporting highly reproducible and automated workflows with minimal solvent consumption.</p><p>The webinar also highlights key system features, including efficient handling of aqueous samples, integration into common GC-MS platforms, and the analytical advantages of V-ITEX compared with established headspace approaches.</p><blockquote><p><strong>Presenter:</strong> Thomas Albinus (Product Manager at GERSTEL)</p></blockquote><blockquote><p><strong>Presenter:</strong> Stefan Cretnik (Product Manager at CTC Analytics)</p></blockquote>

Gerstel: How V-ITEX Enhances Headspace Analysis

Technology Overview - How V-ITEX Enhances Headspace Analysis

Boost GC-MS sensitivity with GERSTEL V-ITEX. Master vacuum-assisted headspace extraction and dynamic sorption for low-temperature VOC analysis

V-ITEX Enhances Headspace Analysis

<p><strong>Part 2: Application Overview – V-ITEX in Practice Across Multiple Fields</strong></p><p>In the second webinar, Lucie K. Tintrop from Agroscope, where the technique was originally developed, joins Thomas Albinus and Stefan Cretnik to present V-ITEX from an application perspective.</p><p>Using practical examples, the session shows how V-ITEX can improve sensitivity, expand the detectable analyte range, and support efficient automated analysis in fields such as food analysis, biotechnology, agricultural science, and metabolomics.</p><p>Special attention is given to the benefits of the technique for volatile compound analysis in complex matrices and biological samples, as well as for aroma-related applications and nutritional volatolomics.<br>This webinar is aimed at analysts and researchers who want to better understand where V-ITEX can add value in real laboratory workflows and how the technique can be applied in both industrial and scientific environments.</p><blockquote><p><strong>&nbsp;Presenter: </strong>Lucie K. Tintrop (Research Associate in the Human Nutrition, Sensory Science and Flavour Group at Agroscope)</p></blockquote><blockquote><p><strong>Presenter:</strong> Thomas Albinus (Product Manager at GERSTEL)</p></blockquote><blockquote><p><strong>Presenter:</strong> Stefan Cretnik (Product Manager at CTC Analytics)</p></blockquote>

Gerstel: V-ITEX in Practice Across Multiple Fields

Application Overview - V-ITEX in Practice Across Multiple Fields

Discover how V-ITEX is applied in food analysis, biotechnology, agricultural science, and metabolomics

V-ITEX in Practice Across Multiple Fields

<div><div id="inner_content_body_text" data-content-id="394785"><p><strong>In today’s oil and gas industry, real-time process insights are critical to improving efficiency, product quality, and regulatory compliance.</strong></p><p>Join this webinar to learn how advanced analytical technologies—including online Raman spectroscopy, process mass spectrometry, and total sulfur analysis—enable continuous monitoring and faster decision-making across refinery operations.</p><h5><strong>These key topics and technologies will be covered:</strong></h5><ul><li><strong>Online Raman spectroscopy:</strong> Real-world examples of monitoring key properties such as API gravity, RON, RVP, cetane, and flash point, aligned with ASTM methods. Applications across natural gas, hydrogen, refined fuels, sustainable aviation fuel (SAF), and cracking processes.</li><li><strong>Process mass spectrometry: </strong>Real-time, multi-component gas analysis in seconds—providing faster and more accurate insights compared to traditional lab-based or GC methods.</li><li><strong>Total sulfur analysis: </strong>Ensuring compliance with global standards (e.g., Tier 3 and Flare Rules) using the SOLA iQ platform.</li><li><strong>LDAR &amp; fugitive emissions: </strong>Best practices for leak detection to minimize product loss and meet environmental regulations.</li></ul><blockquote><p><strong>Presenter:</strong> Dr. Dilip Raut (Product Application Manager – Molecular, Thermo Fisher Scientific)</p><p>Dr. Dilip Raut is a commercially driven product and application leader with 16+ years of experience spanning analytical instrumentation, pharmaceutical R&amp;D, academia, and global cross-functional collaboration. His expertise lies in transforming advanced spectroscopy technologies into scalable business growth strategies across international markets. His expertise lies in Raman spectroscopy (research, microscopy, and process Raman), FTIR, NIR, and UV-Vis technologies, with strong experience in Process Analytical Technologies (PAT). He bridges the gap between advanced spectroscopy solutions and real-world industrial applications.</p><p><strong>Presenter: </strong>Mr. Sharad Garg (Business Development &amp; Proposal Manager, Thermo Fisher Scientific)</p><p>Mr. Sharad Garg is a 2014 graduate in Instrumentation &amp; Controls from Thapar university, Patiala. With 11 years of experience in Automation, Measurement and Analytics, he has been actively involved in emission and air quality monitoring, carbon capture utilization and storage, biofuels, and green hydrogen &amp; derivatives. His role is collaborating closely with customers across India and empower organizations to address complex process dynamics, ensuring cleaner and more sustainable energy practices.&nbsp;</p></blockquote></div></div>

Thermo Fisher Scientific: Advanced Analytical Solutions for Oil & Gas

Advanced Analytical Solutions for Oil & Gas

Learn how Raman spectroscopy, process MS, and sulfur analysis support real-time refinery monitoring, compliance, and process optimization.

<p><strong>Discover how today’s advanced peptide technologies are shaping tomorrow’s research, development, and manufacturing success.</strong></p><h5><strong>In this symposium, you'll learn about:</strong></h5><ul><li>Scalable peptide API manufacturing and purification expertise for GLP‑1 class molecules</li><li>Label‑free, real‑time cell‑based bioassays for peptide activity, optimization, and safety testing</li><li>Non‑destructive Raman raw material identification through opaque containers to streamline GMP workflows</li><li>Inert LC/MS strategies for enhanced peptide separation, impurity profiling, and molecular weight confirmation</li></ul><p>This digital symposium explores the innovations shaping the future of peptide‑driven science, featuring modern analytical tools across cell analysis, chemistries, spectroscopy, and mass spectrometry. Experts will reveal practical approaches for integrating these technologies to strengthen and streamline peptide analysis.</p><p>Attendees will gain a clear view of emerging technologies and practical strategies across modern research and applied science. Join the symposium to discover how to connect these advances directly to your own work.</p><p><strong>10:00 - 10:05 - Intro</strong></p><p>Vitan Blagotinsek, Agilent Technologies</p><p><strong>10:05 - 10:20 - Highlight Talk - Scaling the GLP-1 Surge: Peptide API Development, Purification and Manufacturing at AAT</strong></p><p>Wolfgang Schiek, BioVectra</p><p>As the paradigm shift in diabetes management and the surge in anti-obesity drug sales and development are propelling unprecedented demand for complex peptide APIs therapies, reliable high quality peptide API manufacturing and purification are critical. Agilent Advanced Therapeutics provides specialized expertise and scaling capacity for these GLP-1 Agonists. We support our customers from preclinical to commercial through swift, customer-focused implementation in state-of-the-art facilities and are continuously expanding capabilities, true to our commitment: Invested in Science, Invested in You!</p><p><strong>10:20 - 11:05 - Talk 1: Accelerating Synthetic Peptide Discovery, Quality Control, and Safety Testing with xCELLigence Bioassay</strong></p><p>Leyna Zhao, Agilent Technologies</p><p>Synthetic peptides and proteins are rapidly emerging as important therapeutic modalities, driving the need for robust approaches to evaluate biological activity, product quality, and safety throughout development. In this webinar, we will explore how Agilent’s label free xCELLigence Real Time Cell Analysis (RTCA) platforms can support synthetic peptide discovery, quality evaluation, and safety testing through functional, cell based bioassays. Selected case studies will highlight the use of real time, kinetic cellular readouts in peptide discovery and optimization workflows. Evaluation criteria for biological products will be reviewed in the context of ICH Q6B specifications, with emphasis on the role of bioassays in assessing biological activity. In addition, examples of toxicity testing using xCELLigence RTCA—including published vaccine related applications—will demonstrate how real time cell based assays can provide sensitive and reproducible QC results.</p><p><strong>11:10 - 11:50 - Talk 2: Unlocking Deeper Insights into Peptide Purity and Impurity Profiling with LC/MS for GLP-1 RA Characterization</strong></p><p>Holger Stalz, Agilent Technologies</p><p>Synthetic Peptide therapeutics are reshaping the biopharma landscape, and GLP-1 receptor agonists are at the center of that momentum—raising the stakes for purity assessment and impurity profiling. Join this webinar to see how Agilent’s advanced LC/MS workflows help scientists tackle these challenges with greater confidence and efficiency. You’ll learn how the InfinityLab Pro iQ Plus LC/MSD enables reliable peptide purity confirmation, while the Agilent BioQTOF high-resolution LC/MS/MS system supports detailed sequence confirmation and impurity identification. We’ll also show how OpenLab CDS and MassHunter BioConfirm software simplify complex data interpretation, helping QC and R&amp;D teams move faster and make more confident decisions in peptide characterization.</p><p><strong>11:55 - 12:35 - Talk 3: Raman Spectroscopy in Peptide Pharmaceuticals</strong></p><p>Jan Wuelken, Agilent Technologies</p><p>Rapid, non destructive raw material identification (RMID) through all types of packaging. Reliable identity verification of peptides, amino acids, protected building blocks, and excipients is a critical step in peptide manufacturing. The Agilent Vaya Raman Raw Material Identity Verification System is specifically designed to identify raw materials directly through non transparent and opaque containers, without opening the package. By leveraging Spatially Offset Raman Spectroscopy (SORS), Vaya minimizes interference from container walls, liners, and fluorescence. This enables fast and reliable identification through typical peptide pharma packaging, including plastic drums, paper and multi layer bags, FIBCs, and amber glass containers. The through container measurement capability eliminates the need for sampling, significantly reducing the risk of cross contamination and protecting operators from hazardous, highly potent, or sterile materials. At the same time, it streamlines workflows by reducing handling steps and operator exposure. Agilent Vaya supports high throughput, GMP compliant raw material testing, accelerates release to manufacturing, and helps ensure a secure, efficient supply of materials for peptide synthesis and downstream processing—from early development to commercial production.</p><p><strong>12:40 - 13:15 - Talk 4: Advanced Column Solutions to enhance your Peptide Analysis and Purification Workflows</strong></p><p>Katrien Sabbe, Agilent Technologies</p><p>Whether you're optimizing existing methods or developing new ones, this session will equip you with the tools to streamline your peptide characterization and purification. LC analysis of peptides can be challenging due to their sensitivity to metal interactions within chromatographic systems, often leading to poor peak shape and reduced sensitivity. Agilent Altura HPLC columns with Ultra Inert technology overcome these challenges by minimizing metal-analyte interactions. We will illustrate how this innovation enhances resolution, reproducibility, and quantification in reversed phase and HILIC separations of therapeutic peptides such as GLP-1 receptor agonists. Furthermore we will explore preparative techniques and purification workflows, offering tips for achieving high purity and recovery in synthetic peptide purification.</p><blockquote><p><strong>Presenter: </strong>Vitan Blagotinsek (EMEA Marketing Program Manager Bio/Pharma, Agilent Technologies)</p><p>Vitan is the Agilent Marketing Manager for the Pharma and Biopharma markets across the EMEA region, covering a broad portfolio of all Agilent products with relevance to these markets. Prior to this role, he had started at Agilent as a Chromatography and Sample prep-focused Product Specialist targeting the Biopharma market in the DACH region. His scientific background is in Protein Biochemistry/Structural Biology. He graduated in Biochemistry from the University of Oxford in the UK and has a PhD from Marburg University in Germany (Department of Chemistry).</p></blockquote><blockquote><p><strong>Presenter:&nbsp;</strong>Wolfgang Schiek (Director Business Development, BIOVECTRA, Agilent Technologies)</p><p>Wolfgang is the BD Director Europe for Agilent Advanced Therapeutics, where he specializes in bespoke CDMO solutions and a chemist by profession. With a 25-year track record at industry leaders like Evonik, Cambrex, and Novasep in a variety of technical, commercial and strategic roles, he has helped numerous clients bridge the gap from drug development to successful market launch. For the past four years at AAT, he has focused on the cutting edge of biologics and peptides, serving as one of the primary forces behind the company’s GLP-1 programs.</p></blockquote><blockquote><p><strong>Presenter: </strong>Leyna Zhao (Product Marketing Director, Agilent Technologies)</p><p>Leyna is Product Marketing Director at Agilent Technologies, where she leads global strategy for cell analysis platforms, including xCELLigence Real-Time Cell Analysis (RTCA). With over 20 years of experience in molecular biology, immunology, and drug discovery, she bridges scientific innovation with market adoption. Her work focuses on advancing label-free, real-time technologies that support small molecule screening, immune cell function analysis, and predictive toxicology. She holds a PhD in Biochemistry and has been instrumental in aligning Agilent’s cell analysis solutions with emerging regulatory trends, such as non-animal testing methodologies.</p></blockquote><blockquote><p><strong>Presenter: </strong>Jan Wuelfken (Product Specialist, Molecular Spectroscopy EMEA IDO, Agilent Technologies)</p><p>Jan graduated from the University of Hamburg in 1997 with a thesis about NMR-based conformation analysis of an antimicrobial peptide and in 2001 with his PhD thesis about CD4-binding peptides as inhibitors for HIV infection. He joined Varian Inc. in 2001 as a sale representative for molecular spectroscopy and with the takeover of Varian by Agilent 2010 he became a product specialist for molecular spectroscopy in the Agilent International Distributor Organization (IDO). Today his responsibility is the full Agilent Molecular Spectroscopy Portfolio which is UV-Vis, UV-Vis/NIR, Fluorescence, FT-IR and Raman Spectroscopy.</p></blockquote><blockquote><p><strong>Presenter:&nbsp;</strong>Holger Stalz (LCMS Product Specialist, Agilent Technologies )</p><p>Holger has worked as a product specialist for LC/MS for Agilent in Austria and Switzerland since 2011. He leads a team of European BioPharma Specialists focusing on biopharmaceutical applications and has been coordinating the development of new analytical solutions and methods for protein therapeutics and oligonucleotide-based products.</p></blockquote><blockquote><p><strong>Presenter:&nbsp;</strong>Katrien Sabbe (Biopharma Business Development Manager, Agilent Technologies)</p><p>For more then 25 years Katrien has been working in the field of Chromatography Columns and Supplies, first at VWR International and later at Varian Analytical Instruments, which was acquired in 2011 by Agilent Technologies. Currently, she is the EMEA Biopharma Business Development Manager at Agilent Technologies Chemistries and Supplies Division.</p></blockquote>

BiteSizeBio: Innovations and Emerging Tools in Peptide Science

Innovations and Emerging Tools in Peptide Science

Explore advanced peptide technologies. Learn about GLP-1 API manufacturing, xCELLigence bioassays, through-container Raman RMID, and inert LC/MS workflows

Advanced Peptide Technologies and GLP-1 Analysis

<p><strong>Today’s demanding GC and GC/MS applications place increasing pressure on laboratory productivity and operating costs. While advancements in GC column inertness over the past decade have enhanced data quality, improved inertness alone is no longer sufficient for laboratories striving to remain competitive. Agilent’s premium 5Q columns build on Ultra Inert performance with added premium GC column features including enhanced thermal stability, ultra‑fast conditioning, and extended column lifetime. Join this webinar to see how these premium features can elevate your analytical performance and drive meaningful improvements in productivity.</strong></p><blockquote><p><strong>Speaker: </strong>Ashlee Gerardi (Product Marketing, Agilent Technologies, Inc.)</p><p>Ashlee Gerardi is a GC Columns Product Manager at Agilent Technologies. After receiving her B.S. in Chemistry, Ashlee began her career as an R&amp;D chemist, where she developed novel stationary phases and surface deactivations for GC columns. Ashlee then received her MBA and transitioned to business development overseeing the cannabis and hemp markets. She then served as a market manager for the chemicals, semiconductor, and mining segments.Within her current role at Agilent, Ashlee is currently working on commercializing new GC columns and workflows.&nbsp;</p></blockquote>

Agilent Technologies: Becoming a Better Chromatographer - Webinar Series

Becoming A Better Chromatographer: Understanding the Impact of Advanced GC Column Features for Improving Productivity and Data Quality in GC/MS Workflows

Improve GC/MS workflows with Agilent 5Q columns. Benefit from enhanced thermal stability, ultra-fast conditioning, and ultra-inert peak shapes

Agilent 5Q Columns for Advanced GC/MS Workflows

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Ready to modernize your dioxin analysis? Join this webinar to learn about the Orbitrap Exploris™ GC S mass spectrometer and its application in dioxin analysis for food control laboratories. The session will outline how high-resolution GC-MS with Orbitrap technology can deliver the analytical performance required for regulatory compliance. It will also consider how such approaches support the analysis of dioxins and other persistent organic pollutants in routine workflows. The presenters - Dr Kerstin Krätschmer &nbsp; (Wageningen Food Safety Research) and Dominic Roberts (Thermo Fisher Scientific), will present application data, review analytical performance against regulatory criteria, and discuss current challenges in dioxin analysis, including considerations when evaluating alternatives to traditional magnetic sector GC-HRMS systems.</strong></p><h4><strong>Learning points</strong></h4><ul><li>Learn about the new Orbitrap Exploris GC S released at ASMS 2026.</li><li>See how high-resolution GC-MS meets dioxin regulatory requirements and expands analytical capability.</li><li>Learn how to modernize workflows for simpler, future-ready dioxin &amp; POPs analysis.</li></ul><h4><strong>Who should attend?</strong></h4><ul><li>Laboratory managers, supervisors, and analysts working in food safety and environmental labs.</li><li>Analysts performing dioxin and POPs analysis interested in learning about latest technology and application approach.</li></ul><blockquote><p><strong>Presenter: </strong>Dr Kerstin Krätschmer (Head of the Dutch National Reference Laboratory for POPs, Wageningen Food Safety Research (WFSR))</p><p>Kerstin has a PhD in food chemistry and is currently head of the Dutch NRL POPs situated at Wageningen Food Safety Research (WFSR) in Wageningen, the Netherlands. She earned her PhD at the European Union Reference Laboratory for halogenated POPs in Freiburg, Germany, exploring polychlorinated alkanes analysis using GC-Orbitrap-HRAM. Within her current work as researcher in the contaminants team at WFSR, she covers a wide range of topics from PCDD/Fs to radioactivity in food, looking into new detection methods, fate in the circular food system, emerging risks and crisis preparedness.</p><p><strong>Presenter:&nbsp;</strong>Dominic Roberts (Product Marketing Manager, GC Orbitrap MS, Thermo Fisher Scientific)</p><p>Dominic Roberts has been closely involved with the Thermo Scientific GC Orbitrap MS since its launch in 2015. He started at Thermo Fisher Scientific as a Senior Applications Specialist for the product and is currently the GC Orbitrap MS Product Marketing Manager. Dominic is an experienced analytical chemist and mass spectrometrist with more than 25 years of experience using state-of-the-art analytical systems. He has worked in both a regulatory and industrial environment with GC–MS and LC–MS systems to investigate a variety of chemicals in food, biological, and environmental samples.</p></blockquote></div></div></div>

Thermo Fisher Scientific: Modernizing Dioxin Analysis for Food Control: Introducing a New GC Orbitrap

Modernizing Dioxin Analysis for Food Control: Introducing a New GC Orbitrap

Join webinar to learn about Orbitrap Exploris GC S mass spectrometer and its application in dioxin analysis for food control laboratories.

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