Clarity 10.2 expands instrument control capabilities with new control modules and updates the MS extension to help you work more efficiently.<h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity</a> 10.2 highlights</h4><ul><li>New and updated control modules</li><li>Improved MS data import and export</li><li>Obsolete hardware support ended</li></ul><h4>Instrument control modules</h4>Clarity 10.2 introduces new instrument control modules from Annuo (AS-3117, FAS-3823) and updated instrument controls form Sykam and Ecom.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Instrument_control_modules_5de26782b0.jpg" alt="DataApex: Instrument control modules" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Instrument_control_modules_5de26782b0.jpg 228w," sizes="100vw" width="380" height="260"><h4>MS data import/export improvements</h4>Clarity improves MS data exchange, especially for *.cdf files. MS instruments now support export and import of multiple spectral data and non-spectral signal data in the same CDF file. Import also better handles uniform sampling information, m/z Step values, scale factors, and file names with non-ASCII characters. Exporting individual chromatogram signals from MS instruments is now available through a separate Export Chromatogram dialog.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg" alt="DataApex: MS data import-export improvements" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg 228w," sizes="100vw" width="378" height="259"><h4>Obsolete hardware support terminated</h4>Due to changes in Windows driver security requirements, this update discontinues support for obsolete hardware, including INT7, INT9, U-PAD, U-PAD2, and CB20.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg" alt="DataApex: Obsolete hardware support terminated" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg 228w," sizes="100vw" width="378" height="259"><blockquote>Explore the complete list of all changes, fixes, and additions in version 10.2.👉<a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1">See the complete changelog&nbsp;</a></blockquote>

Clarity Chromatography Software 10.2 released!

Traditional EI library searching works exceptionally well when the unknown compound is already present in the spectral library. However, analytical chemists frequently encounter compounds that are structurally related to library entries but are not exact matches. NIST's EI Hybrid Search addresses this challenge by combining conventional spectral matching with mass-shifted fragment alignment, allowing the identification of analogs, derivatives, and novel compounds that may not exist in the database.This guide summarizes the workflow presented by James Little and demonstrates how to use NIST 26 Hybrid Search in conjunction with the Chromatogram Window and MS Interpreter to obtain more meaningful structural information from unknown EI GC-MS spectra.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/paper/33370">You can download PDF Handout for this guide HERE</a></blockquote><h4>Why Hybrid Search Matters</h4>Conventional EI library searching relies on direct matching between an unknown spectrum and spectra stored in a library. Hybrid Search expands this concept by allowing fragment ions to be matched even when they are shifted by a consistent mass difference (Δm). This enables the software to recognize compounds that differ by substituents or structural modifications.Key advantages include:<ul><li>Identification of structurally related compounds not present in the library</li><li>Detection of analogs, derivatives, and emerging compounds</li><li>Integration of exact fragment matches and mass-shifted matches into a single score</li><li>Improved interpretation of unknowns through proposed structural modifications</li><li>Enhanced confidence when molecular weight information is available</li></ul>Although Hybrid Search does not require the molecular ion to be present, performance improves significantly when the molecular weight can be estimated or constrained. In these cases, the observed mass difference between the unknown and library compounds can often be translated directly into a plausible chemical modification.<h4>Configuring Hybrid Search</h4>Before performing a search, the Hybrid Search settings should be configured within the NIST Library Search window.Recommended settings:<ul><li>Select the Similarity search mode</li><li>Enable Hybrid Search</li><li>Keep the In Spectrum option checked under normal circumstances</li><li>Allow the software to estimate the molecular weight automatically</li><li>If the estimated molecular weight appears incorrect, manually enter a nominal molecular weight</li><li>Select all relevant libraries (NIST, Wiley, user libraries, etc.)</li><li>Save the configuration for future use</li></ul>The selected molecular weight used to constrain the search is displayed in the lower-right corner after the search is completed.<h4>Optimizing the Results Display</h4>Hybrid Search produces several unique parameters that are not shown in the default results table.Additional columns should be added by right-clicking within the results table and selecting Properties. Recommended columns include:<ul><li>DeltaMass</li><li>dForm</li><li>pctRelForm</li><li>o.Match (equivalent to the traditional EI Normal Match score)</li></ul>Without these parameters, much of the structural interpretation power of Hybrid Search is lost.<h4>Working with Spectra from the Chromatogram Window</h4>Currently, the Chromatogram Window performs standard EI library searching. When a potentially interesting unknown is encountered:<ul><li>Perform the normal EI search in the Chromatogram Window</li><li>Send the spectrum to the standalone Library Search module</li><li>Perform a Hybrid Search using the enhanced Hybrid Search functionality</li></ul>This workflow combines rapid screening with advanced structural interpretation.<h4>Understanding Key Hybrid Search Parameters</h4><h5>DeltaMass (Δm)</h5>DeltaMass represents the mass difference between the unknown compound and the matched library compound.A consistent Δm across multiple high-scoring hits often indicates a specific structural modification.<h5>dForm</h5>dForm provides a proposed elemental composition that explains the observed mass difference.Examples include:<ul><li>H–1F</li><li>CH₂</li><li>O–1</li><li>C₁H₃F</li></ul>These transformations can suggest likely chemical modifications between the library compound and the unknown.<h5>pctRelForm</h5>New in NIST 26, pctRelForm estimates how frequently a given elemental transformation occurs relative to the most common transformation (CH₂ = 100%).Interpretation:<ul><li>High values indicate chemically plausible and commonly observed transformations</li><li>Very low values suggest the proposed transformation may be accidental or unlikely</li></ul><h5>o.Match</h5>Represents the traditional EI match score and allows comparison between standard searching and Hybrid Search results.<h4>Case Study: Identifying a Fluorinated Unknown</h4>The presentation demonstrates the identification of an unknown compound with a proposed molecular weight of 152 Da.Hybrid Search returned several high-scoring hits with consistent evidence suggesting fluorine substitution:Hit #1<ul><li>Library MW: 134</li><li>DeltaMass: +18</li><li>dForm: H–1F</li><li>Interpretation: Addition of fluorine</li></ul>Hit #5<ul><li>Library MW: 138</li><li>DeltaMass: +14</li><li>dForm: CH₂</li><li>Interpretation: Related fluorinated analog</li></ul>Hit #6<ul><li>Library MW: 168</li><li>DeltaMass: –16</li><li>dForm: O–1</li><li>Interpretation: Structurally consistent fluorinated compound</li></ul>Multiple independent hits converged on the same conclusion: the unknown was likely a fluorinated analog of known aromatic compounds.This illustrates the major strength of Hybrid Search: identifying structural relationships even when the exact compound is absent from the library.<h4>Moving from Hybrid Search to Structural Interpretation</h4>Once a plausible structure is identified:<h5>Step 1 – Export the Structure</h5>From the Hybrid Search results:<ul><li>Right-click the best hit</li><li>Use Send To → Default Structure Editor</li><li>Open the structure in a drawing program such as ChemSketch</li><li>Copy the proposed structure to the clipboard</li></ul><h5>Step 2 – Open MS Interpreter</h5>Within MS Interpreter:<ul><li>Paste the proposed structure</li><li>Load the unknown spectrum</li><li>Compare predicted fragmentation with observed ions</li><li>Evaluate isotope patterns and fragment assignments</li></ul><h5>Step 3 – Validate the Proposal</h5>Indicators of a good structural proposal include:<ul><li>Consistent isotope ratios</li><li>Logical fragmentation pathways</li><li>Agreement between observed and predicted fragment ions</li><li>Multiple Hybrid Search hits supporting the same structural modification</li></ul>In the example presented, MS Interpreter showed excellent agreement between the proposed fluorinated structure and the observed EI spectrum, although the exact positions of the fluorine and methyl substituents on the aromatic ring could not be definitively assigned.<h4>Best Practices</h4><ul><li>Always review DeltaMass, dForm, and pctRelForm together</li><li>Do not rely solely on the highest match score</li><li>Give greater weight to transformations supported by multiple independent hits</li><li>Use molecular weight information whenever possible</li><li>Confirm structural hypotheses using MS Interpreter</li><li>Consider Hybrid Search as a structure-elucidation tool rather than simply a library search tool</li></ul><h4>Conclusion</h4>NIST 26 Hybrid Search significantly extends the capabilities of conventional EI library searching by identifying structural relationships between unknown compounds and library entries. Through the use of DeltaMass calculations, elemental transformation analysis (dForm), and statistical plausibility metrics (pctRelForm), Hybrid Search provides valuable clues for elucidating compounds that are absent from spectral libraries.When combined with MS Interpreter, it becomes a powerful workflow for the characterization of unknowns, analogs, degradation products, metabolites, and emerging compounds in EI GC-MS analysis.

Lib Search: Similarity EI Hybrid Search for Spectra Sent from Chromatogram Window

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 22nd June 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you brochure by Agilent Technologies, application note by Shimadzu and posters by MDCW / William &amp; Mary and Waters Corporation / ASMS!<h3>1. Agilent Technologies: Operational efficiency for your GC and GC/MS labs with the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B">Agilent 8890B gas chromatography system</a></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/br_8890b_gc_5994_9205en_agilent_fb5db29527.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div><h4>Analyze more samples every day with faster cycle times&nbsp;</h4>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B">8890B GC </a>provides faster maximum oven temperature ramps and cooldown rates for conventional dual-channel GC. If you want even faster cycle times, an optional rapid cooling fan is available.&nbsp;<h4>Achieve excellent repeatability across multiple injections&nbsp;</h4>Consistent retention time and area count performance are the cornerstone of what you can expect from the 8890B GC. The system also meets all specifications required for regulatory methods such as USP Method &lt;467&gt; (residual solvents).<h4>Shine a new light on your connections and components&nbsp;</h4>Make maintenance easier and faster with a built-in oven light that illuminates the internal space on the 8890B GC. That means you can perform tasks like troubleshooting and column installation in less time—and with fewer errors.<h4>Boost GC performance with capillary flow technology&nbsp;</h4><ul><li>Backflush significantly reduces timing between injections, increasing productivity.&nbsp;</li><li>Purged Ultimate unions provide leak-free connections, reducing downtime.&nbsp;</li><li>Flow splitters enable data collection from up to three detectors.&nbsp;</li><li>New CFT calculators let you download calculated setpoints to your method—avoiding time-consuming, error-prone manual input.&nbsp;</li><li>Multidimensional chromatography:&nbsp;<ul><li>Deans Switch facilitates heart cutting, enabling resolution of trace compound in complex matrices.&nbsp;</li><li>GC x GC flow modulation enables multidimensional chromatography without the need for cryogen</li></ul></li></ul><h4>Helium conservation module&nbsp;</h4>Extend the life of your helium tanks by up to 30 times. The Agilent helium conservation module allows you to use helium for your GC runs and switch to a different gas (typically nitrogen) when your GC is idle. That means you can achieve better control of laboratory operating expenses and avoid workflow disruptions.<h4>Alternative carrier gas support&nbsp;</h4>Alternative carrier gases like hydrogen and nitrogen are popular low-cost options.&nbsp;The Agilent Hydrogen Sensor Module Series 2 option adds built-in peace of mind when operating with H2 gas.&nbsp;The Agilent HydroInert source minimizes sensitivity loss and spectral anomalies associated with H2. It also:&nbsp;<ul><li>Maintains spectral fidelity, even for compounds highly susceptible to hydrogenation.&nbsp;</li><li>Improves peak shape for high-boilers, especially polycyclic aromatic hydrocarbons (PAHs)</li></ul><h3>2. MDCW / William &amp; Mary: Decomposition Analysis Using Differing Data Processing Methods to Identify Volatile Organic Compounds</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/P_25_Weina_2ae94f0998.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div>When a body decomposes it emits volatile organic compounds (VOCs). VOCs from decomposing remains have been studied before,1 however there is a gap that remains in the knowledge on VOCs that evolve from submerged decomposing remains. 2 In this study, submerged animal tissue was tested to see how the VOCs can be utilized in forensic settings.&nbsp;This study used data obtained last summer using comprehensive two-dimensional gas chromatography – time-of-flight mass spectrometry (GC×GC-TOFMS). Pigs (Sus scrofa domesticus) are often used as analogs in decomposition studies due to similarities with humans. 3 In this study, pork belly samples were submerged in mason jars filled with water and stored at different temperatures. The GC×GC-TOFMS instrument was used to collect odor from above water samples for a period of twelve days.GC×GC is often used to analyze complex odor profiles. When analyzing samples with GC×GC, there is a lack of standardization to process the data acquired from time trials. There is a need to discover effective ways to track VOCs for chemical identification and longitudinal analysis.The goal of this research was to compare different software approaches to analyze GC×GC longitudinal data to achieve accurate analyte identification, representation of data over time, and effective class characterization.<h4>Methods</h4>For the first four days, 5 mL of water was taken and run on the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37">GC×GC-TOFMS</a>. Thereafter, the samples were sampled and run every three days until day twelve. Data were analyzed initially using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/41">ChromaTOF</a> (LECO Corporation). The samples were then analyzed using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/348">ChromaTOF Tile </a>and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1873">ChromaTOF Sync 2D</a> to compare how they can be used in a forensic setting.Peak tables were curated in Tile and Sync 2D. Then, ChromaTOF was used as a guide to confirm which peaks were identified correctly. If the compound was correctly identified, the peak would be accepted or kept on the table. If not correctly identified, the peak would either be rejected or deleted. Once the tables were complete from the different software approaches, they were exported to Excel for further comparison.In excel, the relevant hits that were identified as decomposition VOCs were compared across the software approaches. The compounds that were most commonly found were compared to existing literature on decomposition VOCs. From there, two tables were built; where one table was compounds confirmed with literature and the other table was compounds not confirmed with literature.Comparison between software approaches included looking at different criteria to see which method was the most effective and efficient. The criteria included how long the software approach took, the number of compounds found in each software approach, the accuracy of peak area in the software approach compared to ChromaTOF data, and principal component analysis (PCA) comparison to see which software approach was best used for forensic practice or research.<h4>Conclusions</h4>Sync 2D showed the capability of showing trends in decomposition compounds<ul><li>This software approach can be used in research environment where longitudinal data is needed to determine the trends of decomposition data&nbsp;</li><li>Best purpose: research applications requiring longitudinal tracking&nbsp;</li></ul>Coefficient of Variance’s and Fold Change’s PCA plots showed their ability for clear class differentiation&nbsp;<ul><li>The two software approaches can be used to distinguish water containing decomposition in a crime scene&nbsp;</li><li>Best purpose: comparison at a single point and time [detailed analysis]&nbsp;</li></ul>Fisher Ratio showed a proficiency in identifying top differentiating compounds and showed aptitude for class differentiation&nbsp;<ul><li>The software approach would be helpful for cursory analysis for crime scene evidence&nbsp;</li><li>Best purpose: quick comparison of biggest difference for swift identification</li></ul><h3>3. Shimadzu: Determination of Ester and Linolenic Acid Methyl Ester Contents in Biodiesel According to EN 14103:2020</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_05_sca_180_054_en_93d1029b72.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=2060">NexisTM GC-2060</a> provides reliable analysis of biodiesel samples regarding their ester and linolenic acid methyl ester contents using hydrogen as a cost-effective carrier gas&nbsp;</li><li>It delivers excellent repeatability and provides appropriate safety measures for the use of hydrogen as carrier gas&nbsp;</li><li>The optional multi-mode injection unit (MMI) offers performance equivalent to a conventional split-splitlessinjection unit (SPL), significantly reducing maintenance downtime</li></ul>Biofuels play an important role in enabling countriesto meet their greenhouse gas reduction targets. They can be produced from a range of raw materials, including plant oils, animal fats, and used cooking oils. Biodiesel is mainly being produced from rapeseed, soybean, and palm oils. Due to this diversity of feedstocks, continuous quality control is necessary as the quality of the raw material has an enormousimpact on the quality of the biodiesel.&nbsp;The EN 14103:2020 describes the determination of total ester content and linolenic acid methyl ester content in biodiesel by means of gas chromatography with flame ionization detection (GC-FID). The total ester content covers a range of fatty acid methyl esters (FAME) from C6 to C24, and linolenic acid methyl ester is investigated separately as interfering reactive compound that might influence long-term stability of the biodiesel. According to the standard, the total ester content must be greater than 90 % (m/m) and the linolenic acid methyl ester content shall be between 1 and 15 % (m/m)1.This study shows the analysis of biodiesel originating from rapeseed,soybean, and palm oil using the Nexis GC-2060.<h4>Multi-Mode Injection Unit as Alternative&nbsp;</h4>Shimadzu’s multi-mode injection unit (MMI) offers reliable splitsplitless mode functionality over a broad range of carbon numbers. It allows analysis of biodiesel samples with high repeatability and provides chromatographic results comparable to those measured with SPL as dedicated split-splitless injection unit. The use of MMI significantly shortens maintenance downtime from tens of minutes for a classical split-splitless injection unit to just a few minutes. Figure 3 gives a direct comparison of an exemplary rapeseed-based biodiesel sample measured with SPL (top) and MMI (bottom).<h4>Conclusion</h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=2060">Nexis GC-2060</a> provides reliable analysis of biodiesel samples regarding their ester and linolenic acid methyl ester content according to EN 14103:2020, covering the various ester types commonly in use. It allows repeatable analysis using hydrogen as a cost-effective carrier gas. The optional multi-mode injection unit (MMI) can be selected as alternative to a classical splitsplitlessinjection unit (SPL).<h3>4. Waters Corporation / ASMS: Putting the (Atmospheric) Pressure on Forever Chemicals: A Targeted Analysis of GC Amenable PFAS using APGC–MS/MS</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009413_dfa4082b45.pdf">Full PDF for download</a></li></ul>This poster presents a targeted analytical method for the determination of gas chromatography (GC)-amenable PFAS compounds using atmospheric pressure gas chromatography coupled with tandem mass spectrometry (APGC-MS/MS). The study addresses a key limitation of conventional LC-MS/MS methods, which are highly effective for many PFAS but less suitable for more volatile species such as fluorotelomer alcohols (FTOHs), fluorotelomer acrylates (FTAcr), and fluorotelomer acetates (FTOAc). By incorporating GC-MS/MS analysis, laboratories can obtain a more complete characterization of PFAS contamination across environmental, biological, and food-contact materials.The analytical workflow utilized an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890">Agilent 8890 gas chromatograph</a> equipped with an autosampler and coupled to a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/554">Waters Xevo TQ Absolute tandem mass spectrometer</a> operated with APGC ionization in positive-ion mode. Separation was performed on an Rtx-200 capillary column, while data acquisition and quantification were managed using <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544">waters_connect software</a>. Unlike traditional electron ionization (EI), APGC generated intact protonated molecular ions, significantly improving sensitivity and selectivity for GC-amenable PFAS. A method covering 35 PFAS compounds was developed, achieving lower limits of quantification (LLOQs) of 0.025–0.1 ng/mL for most analytes.Several sample types were evaluated, including wastewater, surface water, soil, fish tissue, shrimp, and food-packaging materials. Environmental and biological samples were prepared according to EPA Method 1633A and had previously been analyzed by LC-MS/MS, allowing the GC-MS/MS method to serve as a complementary technique. Food-packaging samples were extracted with methanol containing ammonium hydroxide and analyzed for targeted PFAS. While no target PFAS were detected in the tested packaging materials, multiple GC-amenable PFAS were found in environmental samples. Fluorotelomer alcohols were the most frequently detected compounds, with wastewater and ski-wax-impacted soils showing the highest concentrations.The results demonstrate that APGC-MS/MS provides a sensitive and robust solution for the analysis of volatile PFAS classes that may be missed by LC-MS/MS alone. The method delivered accurate quantification, effective chromatographic separation, and reliable recovery in spiked samples. The authors conclude that combining APGC-MS/MS with established LC-MS/MS workflows enables a more comprehensive assessment of PFAS contamination, particularly for emerging fluorotelomer compounds and other GC-amenable PFAS that are increasingly relevant in environmental monitoring and food-packaging investigations.</div></div></div></div></div></div></section></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 26, 2026

Article

Product

Application

Academy

Video

Software

Poster

Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

DataApex

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

James Little/Mass Spec Interpretation Services

Agilent Technologies

Teledyne LABS

SelectScience

Waters Corporation

Transmission Raman spectroscopy (TRS) is a variant of Raman spectroscopy which is advantageous in probing bulk content of diffusely scattering samples. Spatially offset Raman spectroscopy (SORS) is a variant of Raman spectroscopy that allows highly accurate chemical analysis of objects beneath obscuring surfaces. TRS is used in Agilent TRS100 Raman system for fast assay of tablets, capsules, and other dosage forms. SORS is used in Agilent RapID and Vaya systems for see-through barrier verification applications.
This online seminar provides a comprehensive introduction to the TRS and SORS technologies and their applications.
<blockquote>
Presenter: Yanqia Wang, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Dr. Yanqia Wang started working for Agilent Technologies Inc. as a FTIR application Engineer in 2013, providing pre-&amp;post-sale application support. The products he covers from Bench-top FTIR microscopes to various Mobile FTIR spectrometers. Dr. Wang received his PhD of analytical chemistry from Duke University in 2004, doing dynamic IR spectroscopy research. Then he joined Fitzpatrick Center for Photonics at Duke University, doing Tissue Raman spectrometer instrumentation. Since 2007, Dr. Wang worked for Avery Dennison Corp. as a spectroscopist, providing molecular analytical support to the research &amp; development.
</blockquote>

Agilent Technology: Fast assay of Tablets, Capsules, and other Dosage forms using Transmission Raman Spectroscopy and SORS Raman Spectroscopy

Fast assay of Tablets, Capsules, and other Dosage forms using Transmission Raman Spectroscopy and SORS Raman Spectroscopy

This online seminar provides a comprehensive introduction to the TRS and SORS technologies and their applications.

Tablets, Capsules by Raman Spectroscopy and SORS

In this third session of a four-part ‘Fundamentals of Spectroscopy’ course, having previously covered the ‘why’, we’ll now focus on the ‘how’. There is currently a dizzying array of tools available for spectroscopy, but the fundamental goal remains the same.
Here we will discuss the current state-of-the-art common spectroscopy components – spectrometers, detectors, and associated optics – as well as their historical development. We will discuss some of the technological breakthroughs that have made the heroic measurements of yesterday commonplace practice today, as well as how different equipment has evolved to suit the particular needs of different experiments.
Key learning objectives
<ul>
<li>Discover the function of a spectrograph and how the earliest spectrographs achieved this</li>
<li>Understand the difference between a prism and grating spectrograph and learn why grating spectrographs are significantly more common</li>
<li>Consider what is meant by “dispersion” in a spectrometer, what is spectral resolution, and how the two concepts relate to each other</li>
</ul>
Who should attend?
<ul>
<li>Academic researchers</li>
<li>R&amp;D scientists</li>
<li>Lab technicians</li>
<li>Principal investigators</li>
<li>Laboratory, facilities or corporate managers</li>
<li>Postdoctoral research assistants</li>
<li>Undergraduate and PhD students</li>
<li>Engineers or software engineers</li>
<li>Teaching fellows</li>
</ul>
<blockquote>
Presenter: Adam Wise (Andor Technology)
</blockquote>
<blockquote>
Adam Wise is an applications scientist at Andor Technology, specializing in spectroscopy and scientific cameras. He earned his PhD working with John Grey at the University of New Mexico, studying Raman spectroscopy of organic semiconductors. After his postdoctoral research at UMass Amherst, Wise entered the field of optical instrumentation, and continues to support research by helping scientists get the right cutting-edge tools.
</blockquote>
<blockquote>
Presenter: Georgina Wynne Hughes (Editorial Team)
</blockquote>
<blockquote>
Georgina studied at Birmingham University where she gained a BSc in Biomedical Science, and an MSc by Research in Cancer and Genomic Sciences, which focused on defective autophagy in rare neurodegenerative diseases. As a member of the Editorial team, she now plays an integral role in shaping the content on SelectScience.
</blockquote>

SelectScience: Optimizing equipment for optical spectroscopy

Optimizing equipment for optical spectroscopy

In this third session of a four-part ‘Fundamentals of Spectroscopy’ course, having previously covered the ‘why’, we’ll now focus on the ‘how’.

During this second session of a four-part ‘Fundamentals of Spectroscopy’ course, we will break down some common spectroscopic techniques (UV/VIS absorption spectroscopy, photoluminescence, and Raman scattering amongst others), examine how they work at a relatively low level, and discuss what they can be used to learn in different situations. We will pay special attention to the historical developments of these techniques, particularly the scientific and economic motivations that drove the people who created and refined them.
Key learning objectives
<ul>
<li>Understand the concept of absorption spectroscopy, the design of an absorption spectrometer, and see how UV-VIS absorption spectroscopy can be used in quantifying protein concentration.
</li>
<li>Differentiate between the different types of luminescence, specifically photoluminescence vs. fluorescence and understand the basics of fluorescence and phosphorescence spectrometers. Become familiar with applications using time-resolved fluorescence, solvatochromic shifts and Förster resonance energy transfer.
</li>
<li>Learn the basics of Raman spectroscopy, and the design of a Raman spectrometer. Understand the units used in Raman spectroscopy and learn how Raman specificity can be used to measure various physical and chemical properties in materials.
</li>
</ul>
<blockquote>
Presenter Shayne Harrel (Andor Technology)
</blockquote>
<blockquote>
Shayne Harrel is a spectroscopy specialist for the Americas at Andor. He holds a PhD in physical chemistry from Yale University where he studied dynamical processes in charge transfer systems, magnetic materials and semiconductors using time-resolved terahertz spectroscopy. Prior to joining Andor, he was a senior applications engineer at MKS Instruments and has held previous positions as Chief Scientist-Americas for Izon Science, Senior Applications Scientist for Olympus Corporation, and as a chemist for the US Food and Drug Administration.
</blockquote>
<blockquote>
Presenter Georgina Wynne Hughes (Editorial Team)
</blockquote>
<blockquote>
Georgina studied at Birmingham University where she gained a BSc in Biomedical Science, and an MSc by Research in Cancer and Genomic Sciences, which focused on defective autophagy in rare neurodegenerative diseases. As a member of the Editorial team, she now plays an integral role in shaping the content on SelectScience.
</blockquote>

SelectScience: Spectroscopy techniques in practice: Methods and motivations

Spectroscopy techniques in practice: Methods and motivations

We will break down UV/VIS absorption spectroscopy, photoluminescence, and Raman scattering amongst others and examine how they work.

<ul>
<li>Wait what?! Who knew!? There are so many things that a mass spec can do.
</li>
<li>I&#39;ve used it for years, yes this may be true.
</li>
<li>I&#39;ve processed some samples, more than a few.
</li>
<li>But between me and you, I had no idea all the things it could do!
</li>
<li>From sample prep to separation, you just won&#39;t believe…
</li>
<li>All of the tips and tricks we have up our sleeve.
</li>
<li>So, take a few minutes, about 15 should do.
</li>
<li>And learn all the things your mass spec can do.
</li>
</ul>
Building a calibration curve in a quantitative method is required for most LC/TQ studies. In MassHunter Quantitative software, the calibration curve basics will be reviewed and a convenient and quick method for importing the calibration levels from CSV file will be featured.
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Presenter: Hui Zhao, PhD (LC/MS Applications Scientist, Agilent Technologies, Inc.)
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<blockquote>
Hui has 13 years of industry experience developing and validating analytical methods for food/feed nutrition, food safety, dietary supplements and botanicals testing, using a variety of analytical techniques including LC-TQ, LC-QTOF, LC-DAD and GC-MS and a breadth of sample preparation methodologies. She has worked as a Research Scientist at Monsanto, EPL-Bioanalytical Services, Tate &amp; Lyle, Inc. and Lead Staff Scientist at Covance Food Solutions. She holds a Master of Science degree in Analytical Chemistry from Lanzhou University in China and a Ph.D. in Analytical Chemistry from the University of Missouri.
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Prior to becoming a Pre-Sales AE, Hui worked as an LCMS application scientist in Agilent’s global market development group where her primary focus was food and environmental market development.
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<blockquote>
Presenter: Karen Yannell (LC/MS Application Engineer, Agilent Technologies, Inc.)
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<blockquote>
Karen E. Yannell is a LC/MS Application Engineer at Agilent Technologies. She is an expert in small molecule high throughput analysis by triple quadrupole (TQ) and quadrupole time-of-flight (QTOF) mass spectrometry for applied markets. Her recent work has focused on developing routine Q-TOF workflows for both expert and non-expert users alike. Previously, Karen worked on forensic, metabolomics, and biomarker discovery applications with ambient ionization sources. She received her PhD in Analytical Chemistry from Purdue University where studied under the advisement of Prof. R. Graham Cooks. Outside of the laboratory, she enjoys cooking unique dishes and hiking along the beach with her dog.
</blockquote>

Agilent Technologies: Quant Made Easy: Building a Calibration Curve with Agilent MassHunter Quantitative Analysis

Quant Made Easy: Building a Calibration Curve with Agilent MassHunter Quantitative Analysis

In MassHunter Quantitative software, the calibration curve basics will be reviewed and a convenient and quick method for importing...

Building a Calibration with Agilent MassHunter Quantitative

<ul>
<li>Wait what?! Who knew!? There are so many things that a mass spec can do.
</li>
<li>I&#39;ve used it for years, yes this may be true.
</li>
<li>I&#39;ve processed some samples, more than a few.
</li>
<li>But between me and you, I had no idea all the things it could do!
</li>
<li>From sample prep to separation, you just won&#39;t believe…
</li>
<li>All of the tips and tricks we have up our sleeve.
</li>
<li>So, take a few minutes, about 15 should do.
</li>
<li>And learn all the things your mass spec can do.
</li>
</ul>
Thinking of developing a new method utilizing MS? Selecting the best analytical method begins with a decision on how to best separate the analytes of interest. This choice will affect sample preparation and sample introduction, so it is important to get it right early. In this webinar we will review analyte structural properties that make the compound more amenable to either liquid chromatography or to gas chromatography.
<blockquote>
Presenter: Karen Yannell (LC/MS Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Karen E. Yannell is a LC/MS Application Engineer at Agilent Technologies. She is an expert in small molecule high throughput analysis by triple quadrupole (TQ) and quadrupole time-of-flight (QTOF) mass spectrometry for applied markets. Her recent work has focused on developing routine Q-TOF workflows for both expert and non-expert users alike. Previously, Karen worked on forensic, metabolomics, and biomarker discovery applications with ambient ionization sources. She received her PhD in Analytical Chemistry from Purdue University where studied under the advisement of Prof. R. Graham Cooks. Outside of the laboratory, she enjoys cooking unique dishes and hiking along the beach with her dog.
</blockquote>
<blockquote>
Presenter: David Weil, PhD (Senior Applications Scientist, Agilent Technologies, Inc.)
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David Weil is a senior applications scientist in Agilent located in Wood Dale with over 30 years of experience using mass spectrometry. Prior to joining Agilent in 2004, he worked for 14 years at 3M in the Corporate Research Analytical Laboratories (St.Paul, MN) and 4 years at Nicolet/Extrel doing ultra-high resolution mass spectrometry. David received his Ph.D. in Physical Chemistry from the University of Minnesota and Post Doc with Dr Charles Wilkins at University of California-Riverside developing laser desorption FTMS and ion-molecule reactions. David has three grown sons and live with his wife Naomi just blocks from Wrigley Field and Lake Michigan.
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<blockquote>
Presenter: Matt Curtis, PhD (GC/MS Applications Scientist, Agilent Technologies, Inc.)
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Matt joined Agilent in 2013 as a GC/MS applications scientist in the Santa Clara, CA Center of Excellence. His primary responsibility is focused on providing instrument demos for customer interested in each technology Agilent offers; the GC/MS single quadrupole, triple quadrupole and the quadrupole Time-of-Flight. The variety of different samples submitted to the demo lab provide a unique knowledge of optimizing parameters for different applications to provide the best quality data from the instrument.
</blockquote>

Agilent Technologies: Selecting your Separation: Are my Compounds Better for GC or LC

Selecting your Separation: Are my Compounds Better for GC or LC

We will review analyte structural properties that make the compound more amenable to either liquid chromatography or to gas chromatography.

Separation selection: Are my Compounds Better for GC or LC

IR spectroscopy is a ubiquitous analytical technique that was first used during World War II. Since that time it has undergone significant development, providing a means for the analysis of many types of samples both in the laboratory and in the field.
This session will focus on the theory of Infrared and will discuss some modern infrared analytical techniques.
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Presenter: Louis Tisinger, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)
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Louis (Lou) Tisinger has a Ph.D. in Analytical Chemistry from Miami University in Oxford Ohio, where his graduate research involved the study of ATR imaging and microscope performance in vibrational spectroscopy. Most of his career has been related to pre- and post-sales support of FTIR spectrometers, microscopes, imaging systems, and thermal analytical instruments, focusing on analyzing customer samples, demonstrations, post-sales training, troubleshooting, and R&amp;D.
</blockquote>

Agilent Technologies: A discussion on the Theory of FTIR

A discussion on the Theory of FTIR

This session will focus on the theory of Infrared and will discuss some modern infrared analytical techniques.

<h5>Join us Wednesday, June 21, for this information-packed, 30-minute webinar to learn</h5>
<ul>
<li>Fundamentals of Purge and Trap: what it is and how it works</li>
<li>Requirements of a trap and how they adsorb and release volatile compounds</li>
<li>Purge gas selection</li>
<li>The effects of purge parameters on purge efficiency</li>
</ul>
This is a must-attend session if:
<ul>
<li>You work with purge and trap methods in the soil, wastewater and/or drinking water fields</li>
<li>Are a scientist or analyst wishing to learn more about P&amp;T analysis </li>
<li>Are an environmental scientist/technician, analytical chemist or lab manager</li>
</ul>
<blockquote>
Presenter: Amy Nutter (the VOC technical product specialist at Teledyne Tekmar)
</blockquote>
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Amy currently is focused on OEM and customer technical training and application support on the Purge and Trap product line. Previously, Amy worked for the City of Cincinnati in both the drinking water and wastewater laboratories.
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To attend, please select the time on Wednesday, June 21, that works best for you. We look forward to sharing this valuable information.

Teledyne Tekmar: Fundamentals of Purge & Trap

Fundamentals of Purge & Trap

Fundamentals of Purge and Trap. Requirements of a trap. Purge gas selection. The effects of purge parameters on purge efficiency...

How about a 20 minute coffee break along with a bite of Empower? Here you go!
What you can learn: 
<ul>
<li>What&#39;s the difference between Archive and Backup and why do you need both</li>
<li>The cheapest, the fastest, or the most definitive data management strategy is meaningless if the data is untrustworthy</li>
<li>How including a complementary archive strategy to your existing backup will not only improve efficiency, but can reduce costs and regulatory risk</li>
<li>How both approaches are viable and the business value each one can offer</li>
</ul>
Register and prepare a coffee!
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Presenter: Ralf Schröder (Informatics Product Marketing Europe·Waters GesmbH)
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Waters Corporation: Waters Informatics series #5: Archive vs Backup (Po2)

Waters Informatics series #5: Archive vs Backup (Po2)

What's the difference between Archive and Backup and why do you need both?

The calculation of signal to noise ratio is a critical parameter during method development, method validation and routine monitoring the performance of a chromatographic method. Both Limit of Detection (LOD or LDL) and Limit of Quantitation (LOQ or LQL) are based on signal to noise ratio. Empower can calculate signal to noise ratio in many ways. While we designed this functionality in Empower to comply with pharmacopeia requirements, there are alternative methods for this calculation.
Key points of discussion will be:
<ul>
<li>Calculating Signal to Noise ratio as per USP/EP/JP Requirements</li>
<li>Calculating Signal to Noise ratio using other options within the System Suitability option</li>
<li>Calculating Signal to Noise ratio without the System Suitability Option</li>
</ul>
Please join us for a live discussion. As always, don’t forget to bring your Empower questions for this exclusive opportunity to ask our experts anything about Empower Software.
<blockquote>
Presenter: Neil Lander (Principal Product Manager, Waters Corporation)
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<blockquote>
Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager focusing on Informatics solutions. He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.
</blockquote>

Waters Corporation: Empower Tips: Ask Me Anything About Calculating Signal to Noise Ratio

Empower Tips: Ask Me Anything About Calculating Signal to Noise Ratio

The calculation of signal to noise ratio is a critical parameter during method development, validation and monitoring the performance.

Empower Tips: Calculating Signal to Noise Ratio

In this session, explore the operation and latest developments of automated SPME for VOCs and SVOCs by headspace, direct immersion, and derivatization techniques.
Furthermore, discover how SPME has key applications for food, water, environmental and forensic samples for use in laboratories for GC-MS and LC-MS and direct MS analysis.
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Presenter: Hans-Joachim Huebschmann (Consultant, VP Sample Preparation, CTC Analytics)
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SelectScience: Solid phase microextraction – How does it work for my samples?

Solid phase microextraction – How does it work for my samples?

Explore the operation and latest developments of automated SPME for VOCs and SVOCs.

GCMS webinars focusing on Academy/Principles - page 7