Clarity 10.2 expands instrument control capabilities with new control modules and updates the MS extension to help you work more efficiently.<h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity</a> 10.2 highlights</h4><ul><li>New and updated control modules</li><li>Improved MS data import and export</li><li>Obsolete hardware support ended</li></ul><h4>Instrument control modules</h4>Clarity 10.2 introduces new instrument control modules from Annuo (AS-3117, FAS-3823) and updated instrument controls form Sykam and Ecom.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Instrument_control_modules_5de26782b0.jpg" alt="DataApex: Instrument control modules" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Instrument_control_modules_5de26782b0.jpg 228w," sizes="100vw" width="380" height="260"><h4>MS data import/export improvements</h4>Clarity improves MS data exchange, especially for *.cdf files. MS instruments now support export and import of multiple spectral data and non-spectral signal data in the same CDF file. Import also better handles uniform sampling information, m/z Step values, scale factors, and file names with non-ASCII characters. Exporting individual chromatogram signals from MS instruments is now available through a separate Export Chromatogram dialog.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg" alt="DataApex: MS data import-export improvements" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_MS_data_import_export_improvements_a7967a4020.jpg 228w," sizes="100vw" width="378" height="259"><h4>Obsolete hardware support terminated</h4>Due to changes in Windows driver security requirements, this update discontinues support for obsolete hardware, including INT7, INT9, U-PAD, U-PAD2, and CB20.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg" alt="DataApex: Obsolete hardware support terminated" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Data_Apex_Obsolete_hardware_support_terminated_24d9329419.jpg 228w," sizes="100vw" width="378" height="259"><blockquote>Explore the complete list of all changes, fixes, and additions in version 10.2.👉<a target="_blank" rel="noopener noreferrer" href="https://www.dataapex.com/version_history?product=1">See the complete changelog&nbsp;</a></blockquote>

Clarity Chromatography Software 10.2 released!

Traditional EI library searching works exceptionally well when the unknown compound is already present in the spectral library. However, analytical chemists frequently encounter compounds that are structurally related to library entries but are not exact matches. NIST's EI Hybrid Search addresses this challenge by combining conventional spectral matching with mass-shifted fragment alignment, allowing the identification of analogs, derivatives, and novel compounds that may not exist in the database.This guide summarizes the workflow presented by James Little and demonstrates how to use NIST 26 Hybrid Search in conjunction with the Chromatogram Window and MS Interpreter to obtain more meaningful structural information from unknown EI GC-MS spectra.<blockquote><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/paper/33370">You can download PDF Handout for this guide HERE</a></blockquote><h4>Why Hybrid Search Matters</h4>Conventional EI library searching relies on direct matching between an unknown spectrum and spectra stored in a library. Hybrid Search expands this concept by allowing fragment ions to be matched even when they are shifted by a consistent mass difference (Δm). This enables the software to recognize compounds that differ by substituents or structural modifications.Key advantages include:<ul><li>Identification of structurally related compounds not present in the library</li><li>Detection of analogs, derivatives, and emerging compounds</li><li>Integration of exact fragment matches and mass-shifted matches into a single score</li><li>Improved interpretation of unknowns through proposed structural modifications</li><li>Enhanced confidence when molecular weight information is available</li></ul>Although Hybrid Search does not require the molecular ion to be present, performance improves significantly when the molecular weight can be estimated or constrained. In these cases, the observed mass difference between the unknown and library compounds can often be translated directly into a plausible chemical modification.<h4>Configuring Hybrid Search</h4>Before performing a search, the Hybrid Search settings should be configured within the NIST Library Search window.Recommended settings:<ul><li>Select the Similarity search mode</li><li>Enable Hybrid Search</li><li>Keep the In Spectrum option checked under normal circumstances</li><li>Allow the software to estimate the molecular weight automatically</li><li>If the estimated molecular weight appears incorrect, manually enter a nominal molecular weight</li><li>Select all relevant libraries (NIST, Wiley, user libraries, etc.)</li><li>Save the configuration for future use</li></ul>The selected molecular weight used to constrain the search is displayed in the lower-right corner after the search is completed.<h4>Optimizing the Results Display</h4>Hybrid Search produces several unique parameters that are not shown in the default results table.Additional columns should be added by right-clicking within the results table and selecting Properties. Recommended columns include:<ul><li>DeltaMass</li><li>dForm</li><li>pctRelForm</li><li>o.Match (equivalent to the traditional EI Normal Match score)</li></ul>Without these parameters, much of the structural interpretation power of Hybrid Search is lost.<h4>Working with Spectra from the Chromatogram Window</h4>Currently, the Chromatogram Window performs standard EI library searching. When a potentially interesting unknown is encountered:<ul><li>Perform the normal EI search in the Chromatogram Window</li><li>Send the spectrum to the standalone Library Search module</li><li>Perform a Hybrid Search using the enhanced Hybrid Search functionality</li></ul>This workflow combines rapid screening with advanced structural interpretation.<h4>Understanding Key Hybrid Search Parameters</h4><h5>DeltaMass (Δm)</h5>DeltaMass represents the mass difference between the unknown compound and the matched library compound.A consistent Δm across multiple high-scoring hits often indicates a specific structural modification.<h5>dForm</h5>dForm provides a proposed elemental composition that explains the observed mass difference.Examples include:<ul><li>H–1F</li><li>CH₂</li><li>O–1</li><li>C₁H₃F</li></ul>These transformations can suggest likely chemical modifications between the library compound and the unknown.<h5>pctRelForm</h5>New in NIST 26, pctRelForm estimates how frequently a given elemental transformation occurs relative to the most common transformation (CH₂ = 100%).Interpretation:<ul><li>High values indicate chemically plausible and commonly observed transformations</li><li>Very low values suggest the proposed transformation may be accidental or unlikely</li></ul><h5>o.Match</h5>Represents the traditional EI match score and allows comparison between standard searching and Hybrid Search results.<h4>Case Study: Identifying a Fluorinated Unknown</h4>The presentation demonstrates the identification of an unknown compound with a proposed molecular weight of 152 Da.Hybrid Search returned several high-scoring hits with consistent evidence suggesting fluorine substitution:Hit #1<ul><li>Library MW: 134</li><li>DeltaMass: +18</li><li>dForm: H–1F</li><li>Interpretation: Addition of fluorine</li></ul>Hit #5<ul><li>Library MW: 138</li><li>DeltaMass: +14</li><li>dForm: CH₂</li><li>Interpretation: Related fluorinated analog</li></ul>Hit #6<ul><li>Library MW: 168</li><li>DeltaMass: –16</li><li>dForm: O–1</li><li>Interpretation: Structurally consistent fluorinated compound</li></ul>Multiple independent hits converged on the same conclusion: the unknown was likely a fluorinated analog of known aromatic compounds.This illustrates the major strength of Hybrid Search: identifying structural relationships even when the exact compound is absent from the library.<h4>Moving from Hybrid Search to Structural Interpretation</h4>Once a plausible structure is identified:<h5>Step 1 – Export the Structure</h5>From the Hybrid Search results:<ul><li>Right-click the best hit</li><li>Use Send To → Default Structure Editor</li><li>Open the structure in a drawing program such as ChemSketch</li><li>Copy the proposed structure to the clipboard</li></ul><h5>Step 2 – Open MS Interpreter</h5>Within MS Interpreter:<ul><li>Paste the proposed structure</li><li>Load the unknown spectrum</li><li>Compare predicted fragmentation with observed ions</li><li>Evaluate isotope patterns and fragment assignments</li></ul><h5>Step 3 – Validate the Proposal</h5>Indicators of a good structural proposal include:<ul><li>Consistent isotope ratios</li><li>Logical fragmentation pathways</li><li>Agreement between observed and predicted fragment ions</li><li>Multiple Hybrid Search hits supporting the same structural modification</li></ul>In the example presented, MS Interpreter showed excellent agreement between the proposed fluorinated structure and the observed EI spectrum, although the exact positions of the fluorine and methyl substituents on the aromatic ring could not be definitively assigned.<h4>Best Practices</h4><ul><li>Always review DeltaMass, dForm, and pctRelForm together</li><li>Do not rely solely on the highest match score</li><li>Give greater weight to transformations supported by multiple independent hits</li><li>Use molecular weight information whenever possible</li><li>Confirm structural hypotheses using MS Interpreter</li><li>Consider Hybrid Search as a structure-elucidation tool rather than simply a library search tool</li></ul><h4>Conclusion</h4>NIST 26 Hybrid Search significantly extends the capabilities of conventional EI library searching by identifying structural relationships between unknown compounds and library entries. Through the use of DeltaMass calculations, elemental transformation analysis (dForm), and statistical plausibility metrics (pctRelForm), Hybrid Search provides valuable clues for elucidating compounds that are absent from spectral libraries.When combined with MS Interpreter, it becomes a powerful workflow for the characterization of unknowns, analogs, degradation products, metabolites, and emerging compounds in EI GC-MS analysis.

Lib Search: Similarity EI Hybrid Search for Spectra Sent from Chromatogram Window

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 22nd June 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you brochure by Agilent Technologies, application note by Shimadzu and posters by MDCW / William &amp; Mary and Waters Corporation / ASMS!<h3>1. Agilent Technologies: Operational efficiency for your GC and GC/MS labs with the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B">Agilent 8890B gas chromatography system</a></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/br_8890b_gc_5994_9205en_agilent_fb5db29527.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div><h4>Analyze more samples every day with faster cycle times&nbsp;</h4>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B">8890B GC </a>provides faster maximum oven temperature ramps and cooldown rates for conventional dual-channel GC. If you want even faster cycle times, an optional rapid cooling fan is available.&nbsp;<h4>Achieve excellent repeatability across multiple injections&nbsp;</h4>Consistent retention time and area count performance are the cornerstone of what you can expect from the 8890B GC. The system also meets all specifications required for regulatory methods such as USP Method &lt;467&gt; (residual solvents).<h4>Shine a new light on your connections and components&nbsp;</h4>Make maintenance easier and faster with a built-in oven light that illuminates the internal space on the 8890B GC. That means you can perform tasks like troubleshooting and column installation in less time—and with fewer errors.<h4>Boost GC performance with capillary flow technology&nbsp;</h4><ul><li>Backflush significantly reduces timing between injections, increasing productivity.&nbsp;</li><li>Purged Ultimate unions provide leak-free connections, reducing downtime.&nbsp;</li><li>Flow splitters enable data collection from up to three detectors.&nbsp;</li><li>New CFT calculators let you download calculated setpoints to your method—avoiding time-consuming, error-prone manual input.&nbsp;</li><li>Multidimensional chromatography:&nbsp;<ul><li>Deans Switch facilitates heart cutting, enabling resolution of trace compound in complex matrices.&nbsp;</li><li>GC x GC flow modulation enables multidimensional chromatography without the need for cryogen</li></ul></li></ul><h4>Helium conservation module&nbsp;</h4>Extend the life of your helium tanks by up to 30 times. The Agilent helium conservation module allows you to use helium for your GC runs and switch to a different gas (typically nitrogen) when your GC is idle. That means you can achieve better control of laboratory operating expenses and avoid workflow disruptions.<h4>Alternative carrier gas support&nbsp;</h4>Alternative carrier gases like hydrogen and nitrogen are popular low-cost options.&nbsp;The Agilent Hydrogen Sensor Module Series 2 option adds built-in peace of mind when operating with H2 gas.&nbsp;The Agilent HydroInert source minimizes sensitivity loss and spectral anomalies associated with H2. It also:&nbsp;<ul><li>Maintains spectral fidelity, even for compounds highly susceptible to hydrogenation.&nbsp;</li><li>Improves peak shape for high-boilers, especially polycyclic aromatic hydrocarbons (PAHs)</li></ul><h3>2. MDCW / William &amp; Mary: Decomposition Analysis Using Differing Data Processing Methods to Identify Volatile Organic Compounds</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/P_25_Weina_2ae94f0998.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div>When a body decomposes it emits volatile organic compounds (VOCs). VOCs from decomposing remains have been studied before,1 however there is a gap that remains in the knowledge on VOCs that evolve from submerged decomposing remains. 2 In this study, submerged animal tissue was tested to see how the VOCs can be utilized in forensic settings.&nbsp;This study used data obtained last summer using comprehensive two-dimensional gas chromatography – time-of-flight mass spectrometry (GC×GC-TOFMS). Pigs (Sus scrofa domesticus) are often used as analogs in decomposition studies due to similarities with humans. 3 In this study, pork belly samples were submerged in mason jars filled with water and stored at different temperatures. The GC×GC-TOFMS instrument was used to collect odor from above water samples for a period of twelve days.GC×GC is often used to analyze complex odor profiles. When analyzing samples with GC×GC, there is a lack of standardization to process the data acquired from time trials. There is a need to discover effective ways to track VOCs for chemical identification and longitudinal analysis.The goal of this research was to compare different software approaches to analyze GC×GC longitudinal data to achieve accurate analyte identification, representation of data over time, and effective class characterization.<h4>Methods</h4>For the first four days, 5 mL of water was taken and run on the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37">GC×GC-TOFMS</a>. Thereafter, the samples were sampled and run every three days until day twelve. Data were analyzed initially using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/41">ChromaTOF</a> (LECO Corporation). The samples were then analyzed using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/348">ChromaTOF Tile </a>and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1873">ChromaTOF Sync 2D</a> to compare how they can be used in a forensic setting.Peak tables were curated in Tile and Sync 2D. Then, ChromaTOF was used as a guide to confirm which peaks were identified correctly. If the compound was correctly identified, the peak would be accepted or kept on the table. If not correctly identified, the peak would either be rejected or deleted. Once the tables were complete from the different software approaches, they were exported to Excel for further comparison.In excel, the relevant hits that were identified as decomposition VOCs were compared across the software approaches. The compounds that were most commonly found were compared to existing literature on decomposition VOCs. From there, two tables were built; where one table was compounds confirmed with literature and the other table was compounds not confirmed with literature.Comparison between software approaches included looking at different criteria to see which method was the most effective and efficient. The criteria included how long the software approach took, the number of compounds found in each software approach, the accuracy of peak area in the software approach compared to ChromaTOF data, and principal component analysis (PCA) comparison to see which software approach was best used for forensic practice or research.<h4>Conclusions</h4>Sync 2D showed the capability of showing trends in decomposition compounds<ul><li>This software approach can be used in research environment where longitudinal data is needed to determine the trends of decomposition data&nbsp;</li><li>Best purpose: research applications requiring longitudinal tracking&nbsp;</li></ul>Coefficient of Variance’s and Fold Change’s PCA plots showed their ability for clear class differentiation&nbsp;<ul><li>The two software approaches can be used to distinguish water containing decomposition in a crime scene&nbsp;</li><li>Best purpose: comparison at a single point and time [detailed analysis]&nbsp;</li></ul>Fisher Ratio showed a proficiency in identifying top differentiating compounds and showed aptitude for class differentiation&nbsp;<ul><li>The software approach would be helpful for cursory analysis for crime scene evidence&nbsp;</li><li>Best purpose: quick comparison of biggest difference for swift identification</li></ul><h3>3. Shimadzu: Determination of Ester and Linolenic Acid Methyl Ester Contents in Biodiesel According to EN 14103:2020</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_05_sca_180_054_en_93d1029b72.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=2060">NexisTM GC-2060</a> provides reliable analysis of biodiesel samples regarding their ester and linolenic acid methyl ester contents using hydrogen as a cost-effective carrier gas&nbsp;</li><li>It delivers excellent repeatability and provides appropriate safety measures for the use of hydrogen as carrier gas&nbsp;</li><li>The optional multi-mode injection unit (MMI) offers performance equivalent to a conventional split-splitlessinjection unit (SPL), significantly reducing maintenance downtime</li></ul>Biofuels play an important role in enabling countriesto meet their greenhouse gas reduction targets. They can be produced from a range of raw materials, including plant oils, animal fats, and used cooking oils. Biodiesel is mainly being produced from rapeseed, soybean, and palm oils. Due to this diversity of feedstocks, continuous quality control is necessary as the quality of the raw material has an enormousimpact on the quality of the biodiesel.&nbsp;The EN 14103:2020 describes the determination of total ester content and linolenic acid methyl ester content in biodiesel by means of gas chromatography with flame ionization detection (GC-FID). The total ester content covers a range of fatty acid methyl esters (FAME) from C6 to C24, and linolenic acid methyl ester is investigated separately as interfering reactive compound that might influence long-term stability of the biodiesel. According to the standard, the total ester content must be greater than 90 % (m/m) and the linolenic acid methyl ester content shall be between 1 and 15 % (m/m)1.This study shows the analysis of biodiesel originating from rapeseed,soybean, and palm oil using the Nexis GC-2060.<h4>Multi-Mode Injection Unit as Alternative&nbsp;</h4>Shimadzu’s multi-mode injection unit (MMI) offers reliable splitsplitless mode functionality over a broad range of carbon numbers. It allows analysis of biodiesel samples with high repeatability and provides chromatographic results comparable to those measured with SPL as dedicated split-splitless injection unit. The use of MMI significantly shortens maintenance downtime from tens of minutes for a classical split-splitless injection unit to just a few minutes. Figure 3 gives a direct comparison of an exemplary rapeseed-based biodiesel sample measured with SPL (top) and MMI (bottom).<h4>Conclusion</h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=2060">Nexis GC-2060</a> provides reliable analysis of biodiesel samples regarding their ester and linolenic acid methyl ester content according to EN 14103:2020, covering the various ester types commonly in use. It allows repeatable analysis using hydrogen as a cost-effective carrier gas. The optional multi-mode injection unit (MMI) can be selected as alternative to a classical splitsplitlessinjection unit (SPL).<h3>4. Waters Corporation / ASMS: Putting the (Atmospheric) Pressure on Forever Chemicals: A Targeted Analysis of GC Amenable PFAS using APGC–MS/MS</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009413_dfa4082b45.pdf">Full PDF for download</a></li></ul>This poster presents a targeted analytical method for the determination of gas chromatography (GC)-amenable PFAS compounds using atmospheric pressure gas chromatography coupled with tandem mass spectrometry (APGC-MS/MS). The study addresses a key limitation of conventional LC-MS/MS methods, which are highly effective for many PFAS but less suitable for more volatile species such as fluorotelomer alcohols (FTOHs), fluorotelomer acrylates (FTAcr), and fluorotelomer acetates (FTOAc). By incorporating GC-MS/MS analysis, laboratories can obtain a more complete characterization of PFAS contamination across environmental, biological, and food-contact materials.The analytical workflow utilized an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890">Agilent 8890 gas chromatograph</a> equipped with an autosampler and coupled to a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/554">Waters Xevo TQ Absolute tandem mass spectrometer</a> operated with APGC ionization in positive-ion mode. Separation was performed on an Rtx-200 capillary column, while data acquisition and quantification were managed using <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544">waters_connect software</a>. Unlike traditional electron ionization (EI), APGC generated intact protonated molecular ions, significantly improving sensitivity and selectivity for GC-amenable PFAS. A method covering 35 PFAS compounds was developed, achieving lower limits of quantification (LLOQs) of 0.025–0.1 ng/mL for most analytes.Several sample types were evaluated, including wastewater, surface water, soil, fish tissue, shrimp, and food-packaging materials. Environmental and biological samples were prepared according to EPA Method 1633A and had previously been analyzed by LC-MS/MS, allowing the GC-MS/MS method to serve as a complementary technique. Food-packaging samples were extracted with methanol containing ammonium hydroxide and analyzed for targeted PFAS. While no target PFAS were detected in the tested packaging materials, multiple GC-amenable PFAS were found in environmental samples. Fluorotelomer alcohols were the most frequently detected compounds, with wastewater and ski-wax-impacted soils showing the highest concentrations.The results demonstrate that APGC-MS/MS provides a sensitive and robust solution for the analysis of volatile PFAS classes that may be missed by LC-MS/MS alone. The method delivered accurate quantification, effective chromatographic separation, and reliable recovery in spiked samples. The authors conclude that combining APGC-MS/MS with established LC-MS/MS workflows enables a more comprehensive assessment of PFAS contamination, particularly for emerging fluorotelomer compounds and other GC-amenable PFAS that are increasingly relevant in environmental monitoring and food-packaging investigations.</div></div></div></div></div></div></section></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 26, 2026

Article

Product

Application

Academy

Video

Software

Poster

Since 1991 DataApex develops and manufactures chromatography data stations. DataApex is constantly striving to provide users with efficient and up-to-date tools for chromatography data processing.

DataApex

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

James Little/Mass Spec Interpretation Services

Merck

Mettler-Toledo

Agilent Technologies

Technology Networks

Phenomenex

Waters Corporation

We probably have all experienced this at some point when performing gas chromatography where our peak shape suddenly appears a bit different.In this webinar, we will discuss some of the most common chromatographic issues that you experience with Gas Chromatography and take a logical approach to finding the root cause and correcting the problem. Often the best way to approach troubleshooting is to also consider what ‘cannot’ cause an issue so that precious time is not spent addressing something that is not relevant to the symptoms.This webinar will arm you with simple tools, and a different way to look at troubleshooting, should a problem arise.<blockquote>Presenter: Alex Ucci (Application Engineer, Agilent Technologies, Inc.)In his current position at Agilent, Alex provides application assistance and technical support for sample preparation products as well as GC and LC consumables. Before he joined Agilent in 2014, Alex was a graduate student at the Pennsylvania State University researching the morphology and surface properties of aerosol particles using a wide variety of analytical techniques. He has an MS degree in chemistry.</blockquote>

Agilent Technologies: Becoming a Better Chromatographer - Educational Webinar Series

Peak Perfection: A Guide to GC troubleshooting

We will discuss some of the most common chromatographic issues that you experience with Gas Chromatography.

Patient safety and product safety are of the utmost importance for manufacturers of pharmaceuticals and pharmaceutical-related products. Data in the laboratories within these organizations must be managed responsibly and in a compliant fashion.For legacy companies that have been doing business for many years, managing data has changed significantly in the last 30 years. You must exceed current good manufacturing practice (CGMP) requirements to demonstrate your quality management maturity.During this webinar we will explore:<ul><li>Critical aspects of data governance and critical thinking</li><li>Insights and strategies to help navigate the current environment</li><li>Evolving your approach</li><li>Modernizing your way of working</li></ul>Please join us for a lively discussion as we explore this topic. As always, please bring your questions for this exclusive opportunity to ask our experts anything you would like to know about Empower Software.<blockquote>Presenter: Neil Lander (Principal Product Manager, Informatics, Waters Corporation)Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager focusing on Informatics solutions. He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.Presenter: Tracy Hibbs (Principal Consulting Product and Marketing Manager, Waters Corp.)Tracy has worked for Waters Corporation since 1999 and has held a variety of positions including Technical Trainer, Business Impact Consultant, Training Manager for Informatics and Data Integrity, and currently, Principal Consulting Marketing Manager focusing on Informatics solutions. Tracy provides support for Waters Empower Software Suite and is concentrated on developing laboratory data management software solutions that help organizations achieve their scientific and operational objectives in regulated environments. Prior to joining Waters, Tracy was a Research Scientist where she gained experience in chromatography and the associated data systems.​Presenter: Tim Bara (Principal Informatics Consultant, Waters Corporation)Tim has worked for Waters Corporation since 2012 and has held several positions, including a Senior Systems Specialist and currently a Principle Informatics Consultant. As an Informatics Consultant, Tim works with customers to diagnose their Empower System’s overall health and state of control. He is an accomplished Empower implementation expert with over 20 years in system design and development, validation and deployment for both local and global scale Empower environments.</blockquote>

Waters Corporation: Empower Tips: Ask Me Anything About Navigating Data Governance - Risk and Vigilant Monitoring

Empower Tips: Ask Me Anything About Navigating Data Governance - Risk and Vigilant Monitoring

We will explore critical aspects of data governance and critical thinking

Tipy Empower: Zeptejte se mě na cokoli o správě dat

<h4>Eight Webinars and a Roundtable with Experts from Merck&nbsp;</h4>Analytical Excellence Week' is organized to empower professionals in the field of analytical chemistry. Over the course of eight insightful sessions, industry experts will share their knowledge and best practices to streamline your analytical workflows and enhance your efficiency.From understanding quality grades in inorganics and solvents to exploring sustainable practices in the lab, each webinar covers essential topics that will enhance your analytical capabilities. Learn how to optimize your Karl Fischer titration, achieve precision in PFAS testing, and gain troubleshooting tips for LC-MS to effectively address common challenges and improve your laboratory results. The sessions will also address critical aspects of safety and sustainability, ensuring you are well-equipped to handle hazardous chemicals responsibly while making strides toward greener laboratory practices.This is an invaluable opportunity to gain insights that can significantly optimize your analytical processes. Don’t miss your chance to elevate your expertise and contribute to a more efficient and sustainable future in analytical workflows. Each session is specifically designed to address essential topics that directly impact your daily practices, making it relevant for all professionals working in a chemical analysis laboratory.<h3>Day 2: Tuesday, 11 February</h3><h4>Dihydropinene, γ-Valerolactone, and Dimethyl Isosorbide: Bio-Sourced Versatile Green Solvents for Diverse Organic Synthesis</h4>The growing environmental concerns and regulatory restrictions on conventional organic solvents derived from non-renewable sources have spurred the search for greener, sustainable alternatives. This presentation will explore the potential of dihydropinene (DHP), γ-valerolactone (GVL), and dimethyl isosorbide (DMI) as bio-sourced and biodegradable solvents, offering a promising solution to replace toxic and non-renewable solvents. DHP, derived from turpentine oil, is an effective substitute for solvents such as n-hexane, benzene, and dichloromethane, while GVL and DMI are ideal replacements for hazardous solvents such as DMF, NMP, and DMA.These solvents not only perform well in various chemical transformations but also offer significant environmental benefits due to their biodegradability, low toxicity, and recyclability. The presentation will highlight the applications of DHP, GVL, and DMI in green chemistry, showcasing their potential in organic synthesis and industrial processes. It will also discuss their role in advancing sustainable practices, reducing dependency on fossil-based solvents, and promoting safer working environments. By focusing on green solvent solutions, the presentation will emphasize their future potential in scientific research, production, and industrial applications.By attending this webinar, you will learn:<ul><li>Sustainable Solvent Alternatives: How bio-based solvents such as DHP, GVL, and DMI can replace conventional toxic solvents, providing eco-friendly, biodegradable options for chemical processes.</li><li>Environmental and Safety Benefits: The environmental advantages of these solvents, including biodegradability, low toxicity, and recyclability, and how they promote safer and greener practices in research and industry.</li><li>Practical Applications: How these solvents can be effectively used in organic synthesis, industrial processes, and various scientific fields, contributing to more sustainable and efficient chemical solutions.</li></ul>Who should attend: This presentation will benefit those working in pharmaceutical and drug discovery R&amp;D, process development of API, environmental scientists and sustainability experts, industry professionals in chemical engineering and manufacturing, materials science researchers, and students and researchers in green chemistry.<blockquote>Presenter: Saikat Sinha, (R&amp;D Manager, Merck)&nbsp;</blockquote><h4>Enhance Your PFAS Testing: Achieve Precision and Reduce Background Noise with Specialized Consumables</h4>Join this presentation to explore advanced LC-MS/MS methods for determining PFAS analytes at low levels across diverse samples and matrices. Learn how to identify contamination sources, reduce background noise, and improve testing precision with specific recommendations on PFAS-qualified consumables. Discover various LC-MS/MS PFAS testing workflows and strategies to minimize errors, supported by data from both regulated and non-regulated methods.By attending this webinar, you will learn:<ul><li>Detailed insights into different LC-MS/MS PFAS methods</li><li>Techniques to identify and test contamination sources</li><li>Strategies to reduce background noise</li><li>Practical tips and tricks for improved testing</li></ul>Who should attend: This webinar is essential for lab technicians, lab managers, and quality assurance managers involved in developing in-house methods or verifying regulated testing protocols such as EPA Methods 533, 537.1, and 1633.<blockquote>Presenter: Patrik Appelblad, (Fellow and Technical Lead, Analytical Chemistry R&amp;D, Merck)&nbsp;</blockquote>

Merck: Webinar Series & Expert Roundtable

Webinar Series & Expert Roundtable (Day 2)

(Day 2) - Part 1: Dihydropinene, γ-Valerolactone, and Dimethyl Isosorbide: Solvents for Organic Synthesis and Part 2: Enhance Your PFAS Testing

<h4>Eight Webinars and a Roundtable with Experts from Merck</h4>Analytical Excellence Week' is organized to empower professionals in the field of analytical chemistry. Over the course of eight insightful sessions, industry experts will share their knowledge and best practices to streamline your analytical workflows and enhance your efficiency.From understanding quality grades in inorganics and solvents to exploring sustainable practices in the lab, each webinar covers essential topics that will enhance your analytical capabilities. Learn how to optimize your Karl Fischer titration, achieve precision in PFAS testing, and gain troubleshooting tips for LC-MS to effectively address common challenges and improve your laboratory results.The sessions will also address critical aspects of safety and sustainability, ensuring you are well-equipped to handle hazardous chemicals responsibly while making strides toward greener laboratory practices.This is an invaluable opportunity to gain insights that can significantly optimize your analytical processes. Don’t miss your chance to elevate your expertise and contribute to a more efficient and sustainable future in analytical workflows.Each session is specifically designed to address essential topics that directly impact your daily practices, making it relevant for all professionals working in a chemical analysis laboratory.<h3>Day 3: Wednesday, 12 February</h3><h4>Optimize Your Karl Fischer Titration: Expert Insights for Enhanced Results</h4>With Karl Fischer titration, you can quickly and accurately determine water content in a wide variety of samples. The accuracy of the results depends on a well-defined titration application process. Pre-titration and titer determination are essential for obtaining correct results. The main challenges arise from samples that do not dissolve or that undergo side reactions in standard solvents. Learn the measures you can take to release water from such samples and the preferred methods to use—volumetry or coulometry. Additionally, discover how digital data transfer enables efficient, fast, and secure data integration with your titrator software.By attending this webinar, you will learn:<ul><li>The key steps in the Karl Fischer titration process</li><li>The importance of accurate pre-titration and regular titer determination</li><li>Effective methods for completely releasing water from your samples</li><li>How digital data transfer can streamline and secure your daily data transfer and documentation</li><li>Practical tips for overcoming daily challenges in Karl Fischer Titration</li></ul>Who should attend: This webinar will be especially valuable for individuals involved in developing Karl Fischer titration applications, performing titrations in QC labs or during in-process control, and those responsible for assessing and enhancing processes. This includes lab technicians, lab managers, and quality assurance managers across various segments.<blockquote>Presenter: Bettina Straub-Jubb, (Global Product Manager Analytical Technologies, Merck)</blockquote><h4>Beyond Safety Standards – Best Practices for Safe Handling of Hazardous Chemicals</h4>This webinar illustrates the role of safety in the lab as well as the challenges that can occur while handling hazardous goods in the daily lab work and how to overcome these challenges. Rules and regulations for daily handling of hazardous goods are discussed, and options are shown on how to improve daily processes regarding personal safety. The presentation focuses on the prevention of accidents, emergency help in case of chemical spillages, and safe and reliable cleaning of lab equipment. Join the webinar for an informative overview of safety solutions and tools for maximum safety and reliability in your lab.By attending this webinar, you will learn:<ul><li>Basic safety risks and rules for daily handling of hazardous goods and options for how to improve daily processes regarding personal safety</li><li>Packaging-related safety topics</li><li>Practical guidelines for handling hazardous chemicals in case of spillages</li><li>Lab equipment cleaning know-how for reliable analytical results</li></ul>Who should attend: Staff and head of chemical labs (e.g. quality control, research), as well as safety managers/safety engineers for chemical laboratories.<blockquote>Presenter: Annett Schneider, (Global Product Manager and Lead Expert for Safety Products and Essentials, Merck)&nbsp;</blockquote>

Webinar Series & Expert Roundtable (Day 3)

Part 1: Optimize Your Karl Fischer Titration and Part 2: Beyond Safety Standards – Best Practices for Safe Handling of Hazardous Chemicals

<h4>Eight Webinars and a Roundtable with Experts from Merck</h4>Analytical Excellence Week' is organized to empower professionals in the field of analytical chemistry. Over the course of eight insightful sessions, industry experts will share their knowledge and best practices to streamline your analytical workflows and enhance your efficiency.From understanding quality grades in inorganics and solvents to exploring sustainable practices in the lab, each webinar covers essential topics that will enhance your analytical capabilities. Learn how to optimize your Karl Fischer titration, achieve precision in PFAS testing, and gain troubleshooting tips for LC-MS to effectively address common challenges and improve your laboratory results.The sessions will also address critical aspects of safety and sustainability, ensuring you are well-equipped to handle hazardous chemicals responsibly while making strides toward greener laboratory practices.This is an invaluable opportunity to gain insights that can significantly optimize your analytical processes. Don’t miss your chance to elevate your expertise and contribute to a more efficient and sustainable future in analytical workflows.Each session is specifically designed to address essential topics that directly impact your daily practices, making it relevant for all professionals working in a chemical analysis laboratory.<h3>Day 4: Thursday, 13 February</h3><h4>Greener Solvents - Making Big Moves for More Sustainability in the Lab!</h4>Laboratories consume significantly more energy and water and generate more waste than offices or households. This is more reason for laboratories to tackle sustainability concerns now. This training supports labs to become greener by addressing the class of chemicals that are used in the largest volumes in the lab: solvents! According to the 12 Principles of Green Chemistry, solvents are more sustainable when they are biobased or when they are less dangerous and hazardous.This training highlights several of these greener solvent alternatives and how they can be implemented in the lab. Due to the large volume in which solvents are used, changing to a greener alternative will significantly reduce the carbon footprint of a lab. A further opportunity to reduce the carbon footprint of a lab and to tremendously reduce waste, are returnable containers for solvents, which will be covered in the second part of the training.By attending this webinar, you will learn:<ul><li>The 12 Principles of Green Chemistry</li><li>What greener solvents are and how they can be implemented in your lab</li><li>How returnable containers for solvents reduce the carbon footprint and amount of waste in the lab</li></ul>Who should attend: This webinar will provide valuable insights for everybody who is working with solvents in the lab and would like to become more sustainable. This includes lab technicians, lab managers, and scientists in chemistry and analytical chemistry labs.<blockquote>Presenter: Frank Michel, (Scientific Education &amp; Sustainability, Chemistry Franchise, Merck)Presenter: John Cooper, (Global Product Manager Sustainable Solvents, Milwaukee, Wisconsin, USA, an affiliate of Merck)</blockquote><h4>Tips and Tricks for LC-MS Troubleshooting</h4>LC-MS is an excellent tool for chemical analysis. Moreover, the evolution in HPLC particle technology, HPLC instrument design, and MS detection resulted in improved performance and sensitivity. This raised the bar on requirements for the purity of the solvents and additives in the mobile phase. This training provides valuable tips and tricks on how to get the best performance out of your LC-MS instrument regarding sensitivity and how to limit instrument downtime by different approaches. Typical examples of LC-MS issues, such as ghost peaks or noisy and elevated baselines, and how to prevent them will be presented. Advanced LC-MS solvents and additives for improved LC-MS performance and their proper handling will be discussed in detail.By attending this webinar, you will learn:<ul><li>The importance of the choice of consumables and solvents for LC-MS</li><li>Approaches to improve sensitivity and robustness of LC-MS</li></ul>Who should attend: This webinar will be especially valuable for scientists, lab managers, and lab technicians working with LC-MS in any application area.<blockquote>Presenter: Frank Michel, (Scientific Education &amp; Sustainability, Chemistry Franchise, Merck)</blockquote>

Webinar Series & Expert Roundtable (Day 4)

Part 1: Greener Solvents - Making Big Moves for More Sustainability in the Lab! and Part 2: Tips and Tricks for LC-MS Troubleshooting.

Laboratory balance cleaning is extremely important for accurate weighing results and operator safety. It can be challenging but also fast and easy if you know how to do it right.A clean analytical balance or precision balance is the first step toward safe and accurate weighing. Cleaning increases user safety reduces the risk of cross-contamination, and is the most important action to prolong instrument life. Join our free live webinar to find out more about the benefits of and solutions for cleaning your balance.Program:<ul><li>Why cleaning lab equipment is important for safety and weighing accuracy</li><li>The consequences of not cleaning your balances correctly</li><li>How often you should clean your balance</li><li>The detergents that are suitable for balance cleaning</li><li>The balance features that support fast and effortless cleaning</li></ul><blockquote>Presenter: Adriano Guiso (Trainer, METTLER TOLEDO)</blockquote>

Mettler Toledo: Laboratory Balance Cleaning

Laboratory Balance Cleaning

Join our free live webinar to find out more about the benefits of and solutions for cleaning your balance.

Food and environment testing labs face many challenges and are under pressure to maximize efficiency, productivity, and profitability. Customers expect rapid analysis, with testing done using best-in-class instrument and methods that comply with constantly evolving test regulations. Agilent provides instrumentation, software, consumable, services, and support to help you meet your food and environment testing challenges.In this second session we will talk about the analysis of microplastics in the environment and food.<blockquote>Presenter:&nbsp; Dr. Nopparat Vorapalawut (Spectroscopy Solutions Development Manager, Agilent Technologies)Nopparat joined Agilent Technologies in position of Spectroscopy Application Field Service Engineer and is currently Agilent’s Spectroscopy product specialist based in Thailand.She graduated Ph.D. in Analytical Chemistry and having previously worked in post-doctoral researcher in France and join Agilent in 2016.At Agilent, she is supporting in technical sales and requirement from customers.</blockquote>

Agilent Technologies: Optimizing your food environmental testing: Expert tips and insights with atomic and molecular spectroscopy

Molecular Spectroscopy

In this second session we will talk about the analysis of microplastics in the environment and food.

Session 2: Molecular Spectroscopy

<div><div id="inner_content_body_text" data-content-id="394785">Sustainable lab practices are becoming an increasingly important factor to many lab managers and personnel. This webinar will discuss the improvements you could make to your lab’s sustainability goals with the introduction of on-site gas generation.Our expert speakers will explore how on-site gas generation for LC-MS and gas chromatography compares to traditional supplies like cylinders and dewars, illustrating the environmental benefits from gas deliveries to power consumption. &nbsp;<div>Attend this webinar to:</div><ul><li>Discover the best sustainability practices when supplying your LC-MS or GC with nitrogen or hydrogen</li><li>Learn about MyGreenLab’s ACT accreditation and how you can be sure your lab instruments are not negatively impacting the environment</li><li>Find out about the “hidden” impacts of gas generation on your lab’s sustainability efforts&nbsp;</li></ul><blockquote>Presenter: Bruce Peat (Head of Marketing at PEAK Scientific)A data-driven, level-headed, well-disciplined and enthusiastic marketing professional with over 8 years' experience primarily in Scientific and Manufacturing industries. A passion for marketing, understanding customer and consumer needs, with a focus on delivering a customer experience to match.&nbsp;</blockquote></div></div>

Technology Networks: Toward More Sustainable Labs: The Impact of Gas Supply

Toward More Sustainable Labs: The Impact of Gas Supply

This webinar will discuss the improvements you could make to your lab’s sustainability goals with the introduction of on-site gas generation.

<h4>Key Learning Points</h4><ul><li>Understand recovery and reproducibility in the context of Solid Phase Extraction</li><li>Discover the causes of commonly encountered Solid Phase Extraction problems</li><li>Learn how to successfully troubleshoot a Solid Phase Extraction problem quickly and efficiently</li></ul><h4>Who Should Attend</h4><ul><li>Any scientist who is interested in improving their SPE extraction method recovery and reproducibility.</li></ul><blockquote>Speaker: Kevin Zhao (Sr. Technical Specialist, Phenomenex)Kevin Zhao has 5 years of experience in biochemistry research, 4 years of Protein/Cancer research with the CSULA-City of Hope Cancer Collaborative, and over 12 years with Phenomenex. Mr. Zhao is a member of a global Technical Support Team, providing problem-solving, troubleshooting, and application assistance for customers worldwide in the fields of chromatography (liquid and gas) and sample preparation. The industries he supports include pharmaceuticals, biopharmaceuticals, clinical research and toxicology, food safety, environmental analysis, fuels, and specialty chemicals.Mr. Zhao received his B.S. in Biology from California State Polytechnic University, Pomona, his M.S. in Biochemistry from California State University, Los Angeles, and an MBA from the University of the Incarnate Word.</blockquote>

Phenomenex: SPE Troubleshooting: Unlock Maximum Recovery with Expert Tips!

SPE Troubleshooting: Unlock Maximum Recovery with Expert Tips!

Learn how to successfully troubleshoot a Solid Phase Extraction problem quickly and efficiently

SPE Troubleshooting: Unlock Maximum Recovery with Expert

Laboratories depend extensively on digital solutions to enhance their workflows, making it crucial to keep laboratory software up to date. Regardless of whether your lab focuses on pharmaceuticals, environmental testing, or biopharmaceutical research, software serves as the backbone of operations, driving efficiency, ensuring compliance, and protecting data integrity.However, as technology advances, neglecting software updates can result in vulnerabilities, inefficiencies, and lost opportunities for innovation.During this webinar we will concentrate on both Empower and NuGenesis informatics products, including:<ul><li>The top reasons to stay up to date on software versions</li><li>Practical approaches to upgrading software versions</li></ul>Please join us for a lively discussion as we explore this topic. As always, please bring your questions for this exclusive opportunity to ask our experts anything about Empower and NuGenesis Software.<blockquote>Presenter: Neil Lander (Principal Product Manager, Informatics, Waters Corporation)Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager focusing on Informatics solutions. He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.Presenter: Kate Lenton (Principal Product Manager, NuGenesis, Waters Corporation)Kate Lenton is a Principal Product Manager at Waters, with a focus on the NuGenesis informatics portfolio. She has more than 13 years of experience in the Life Science industry. &nbsp;She joined Waters in 2015 as an Application Specialist (NuGenesis and Empower) in Professional Services and then worked as an Informatics Customer Success Manager for Europe. Currently she is the NuGenesis Product Manager. She focuses on ensuring the success of the product by hearing directly from customers about product improvements and new features. She holds a BSc Hons in Veterinary Sciences.&nbsp;</blockquote>

Waters Corporation: Empower Tips: Ask Me Anything About the Importance of Keeping Laboratory Software Updated

Empower Tips: Ask Me Anything About the Importance of Keeping Laboratory Software Updated

During this webinar we will concentrate on both Empower and NuGenesis informatics products.

GCMS webinars focusing on Tips & Tricks - page 5