<blockquote><p>Welcome back to the topic of protecting your GC column! <strong>If you missed part 1</strong> or would like to refresh your knowledge, find further tips on GC column protection <a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/knowledge-center/gc-knowledge-center/protecting-your-gc-column-pt1-tech-tip-en-1025"><strong>here</strong>.</a></p></blockquote><p><strong>Protecting your GC column and instrument components from exposure to dirty samples or contaminants is important. Non-volatile or high molecular weight components can contaminate the stationary phase, causing poor peak resolution, lower accuracy, and poor column lifetime. Cutting off the damaged portion of column tubing will often restore your column’s performance, but over time performance will degrade to a point where the column can no longer be used. If you are experiencing rapid degradation of column performance, there are several simple ways to help protect your column and increase its lifetime.</strong></p><h3><strong>Use A Liner With Wool</strong></h3><p>The liner is the first line of defense for your column, and the style you choose can make a big impact in how much contamination gets onto the column. The easiest thing to do is to add a small amount of silanized glass wool to a liner, which traps the non-volatile compounds and prevents them from entering directly into the column.&nbsp;</p><blockquote><p><strong>Caution: </strong>glass wool can also add activity for acids, bases, and pesticides. Crushing the glass wool can expose undeactivated glass and free silanols (-OH groups) even if the wool has been deactivated. This leads to increased activity, so pre-packed liners, rather than self-packed ones are highly recommended to avoid reproducibility issues.</p></blockquote><p>In addition to choosing a liner with wool, ensure that your liner (and other system consumables) are free of contaminant build-up that may form over time. Septum cores and other particulates that remain can become trapped in the wool and are sometimes difficult to spot. Regularly replace the liner (and other system consumables as needed) to reduce troubleshooting and maintenance.</p><h3><strong>Bake Out Your Column</strong></h3><p>The easiest way to reduce column contamination is to add a short, high temperature bake-out at the end of your standard GC method. This bake out helps remove high boiling contaminants that would otherwise remain in the column and cause damage. To bake out, the final oven temperature needs to be set high enough to ensure elution of these compounds, but not so high as to cause thermal damage. This can be done either isothermally, or more commonly, via an oven ramp until the last components elute from the column. Caution: NEVER exceed the upper temperature limits of your column. DO NOT exceed more than fifteen minutes at the upper isothermal temperature limit specified for the column.</p>

How to Protect Your GC Column - Part 2

<h3><a target="_blank" rel="noopener noreferrer" href="https://www.isc2026.org/"><strong>ISC 2026</strong></a></h3><p>The <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/314"><strong>International Symposium on Chromatography (ISC)</strong></a> represents the oldest conference series on separation science. ISC symposia have been organised since 1956 in each even year. ISC is one of the premier meetings series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.</p><p>The major focus of the symposium will be on the impact of chromatography and separation science to meet the needs of the pharmaceutical, environmental, food and health industry, as well as science and medicine. The symposium programme will reflect these themes and highlight new challenges and emerging opportunities for the science and marketing of separation and detection systems and methods.</p><p>As an integral part of the scientific programme of lectures and poster sessions, an international exhibition and vendor seminars on instrumentation and services for chromatography, separation science and mass spectrometry will be organised. ISC 2026 will provide the perfect forum for attendees from academia, industry and government research institutions for scientific exchange and networking.</p><h3><strong>ISC 2026 SYMPOSIUM KEY DATES</strong></h3><h4><strong>6-10 SEPTEMBER 2026</strong></h4><ul><li><strong>15 January 2026:</strong> Opening of Early-bird Registration &amp; Abstract submission</li><li><strong>11 March 2026: </strong>Deadline for abstract submission (orals)</li><li><strong>21 April 2026: </strong>Sending acceptance letters (orals)</li><li><strong>15 May 2026: </strong>Deadline of early-bird registration and payment &amp; Author registration deadline (orals)</li><li><strong>1 June 2026: </strong>Preliminary detailed program on web</li><li><strong>1 June 2026: </strong>Deadline for abstract submission (posters)</li><li><strong>16 June 2026: </strong>Sending acceptance letters (posters)<ul><li>Authors who submit their abstracts with a poster preference by 5 May 2026 will be notified of the outcome by 12 May 2026 and will have the opportunity to register at the early-bird rate until 15 May 2026.</li></ul></li><li><strong>30 June 2026:</strong> Author registration deadline (posters)</li><li><strong>30 July 2026:</strong> Deadline for abstract submission (late-breaking posters)<ul><li>without the possibility of competing for the Best Poster Award</li></ul></li><li><strong>11 August 2026: </strong>Sending acceptance letters (late-breaking posters)</li><li><strong>18 August 2026:</strong> Author registration deadline (late-breaking posters)</li><li><strong>25 August 2026: </strong>Deadline for late registration &amp; payment&nbsp;</li><li><strong>6-10 September 2026: </strong>Symposium</li></ul><h3><strong>REGISTRATION</strong></h3><blockquote><p><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://www.czech-in.org/cmPortalV15/Account/Login?ReturnUrl=%2FcmPortalV15%2FPortal%2FISC26%2Fnormal"><strong>Register HERE for the ISC 2026</strong></a></p></blockquote><h3><strong>ABSTRACT SUBMISSION</strong></h3><blockquote><p><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://www.czech-in.org/cmPortalV15/Account/Login?ReturnUrl=%2FcmPortalV15%2FPortal%2FISC26%2Fnormal"><strong>Submit your Abstract HERE</strong></a></p></blockquote><h3><strong>SCIENTIFIC PROGRAM</strong></h3><h4><strong>SHORT COURSES</strong></h4><h5><strong>SC 3 Interpretation of Mass Spectra: Basic Introduction for Chromatographers</strong></h5><p><strong>🗓️ SUNDAY, 6 SEPTEMBER 2026</strong></p><p><strong>🕗 8:30 – 11:45</strong></p><p>Mass spectrometry has become an essential tool in modern liquid chromatography, yet many chromatographers receive limited formal training in mass-spectral interpretation. This introductory short course provides a practical guide to understanding and interpreting mass spectra generated by the atmospheric-pressure ionization techniques coupled with LC: electrospray ionization (ESI), atmospheric-pressure chemical ionization (APCI), and atmospheric-pressure photoionization (APPI). The course begins by outlining the information that mass spectrometry adds beyond a chromatogram and clarifying which analytical questions mass spectrometry can – and cannot – answer. Participants receive a concise refresher on mass-spectrometric fundamentals, along with an introduction to key terminology. The principles and practical consequences of ionization methods are then discussed, with emphasis on how ionization physics, LC conditions, and mobile-phase additives shape spectral appearance. Building on this foundation, the course develops practical skills for interpreting LC-ESI spectra: locating the molecular ion, determining charge state, recognizing common adducts, distinguishing in-source artefacts, and using isotope patterns to support elemental-composition hypotheses. Participants then explore how MS/MS fragmentation provides structural clues, with straightforward rules of thumb for neutral losses and class-specific fragmentation behaviors. The course concludes with an integrative exercise that synthesizes chromatographic, full-scan, and MS/MS information to support spectral interpretation. By the end, participants will be equipped with the essential skills needed to interpret LC-MS spectra effectively and to apply mass-spectrometric reasoning in routine chromatographic analysis.&nbsp;</p><h4><strong>Lecturers</strong></h4><h5><strong>Josef Cvačka</strong></h5><ul><li>Josef Cvačka is head of the Mass Spectrometry Group at the Institute of <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/62"><strong>Organic Chemistry and Biochemistry of the Czech Academy of Sciences</strong></a> and an associate professor at the Faculty of Science, Charles University in Prague. His research focuses on the structural analysis of bioactive organic compounds using advanced mass-spectrometric techniques. He develops methods for pinpointing double-bond and methyl-branching positions in lipids and aims to discover new lipid classes in biological samples. His laboratory also designs new ion sources for MS and HPLC/MS. He teaches and supervises students at Charles University and founded the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/articles?search=Czech+Museum+of+Mass+Spectrometry"><strong>Czech Museum of Mass Spectrometry</strong></a>.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Josef_Cvacka_5cc8a0d1d4.jpg" alt="ISC 2026: Josef Cvačka" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Josef_Cvacka_5cc8a0d1d4.jpg 156w," sizes="100vw" width="510" height="510"></p>

ISC 2026 Short Course 3 - Interpretation of Mass Spectra: Basic Introduction for Chromatographers

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 9th February 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you technical note by <strong>Agilent Technologies, </strong>presentation by<strong> MDCW / University of Copenhagen </strong>and<strong> </strong>application notes by<strong> Shimadzu </strong>and<strong> Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: What Causes Spots on </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?instrumentationItems=19&amp;manufacturerItems=1&amp;search=PLOT"><strong>PLOT Columns</strong></a><strong>? Will It Affect the Performance of the Column?</strong></h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_what_causes_spots_plot_columns_affecting_performance_5994_8775en_agilent_3b7180512a.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Spots on porous layer open tubular (PLOT) columns are caused by small voids in the stationary phase coating inside the tube. These spots are areas where there is an uneven coating or lack of phase. It is normal to find some voids in the phase coating of PLOT columns. The stationary phase in PLOT columns is an opaque, solid, and porous material. In many Agilent PLOT columns such as the GS-Alumina phases, molecular sieves, porous polymers (Q and U), and the GS-OxyPLOT, the stationary phase is visible as a white powder. For many PLOT columns, the stationary phase fill solution is a viscous suspension of particles that are less than 10 microns in diameter. The phase is coated using a dynamic process in which a plug of fill solution is pushed through the tubing, and the plug’s speed and viscosity determines the thickness of the stationary phase layer. Once the PLOT’s stationary phase is deposited, it is held in place by electrostatic charge, chemical interactions between particles, and/or binding agents. In wall‑coated open tubular (WCOT) columns, stationary phases such as polysiloxanes or polyethylene glycols are immobilized by chemical bonding to the glass surface and cross-linking between polymer strands. Because this type of bonding and cross‑linking is not possible with PLOT phases, the result is a stationary phase layer that is both fundamentally different and inherently less stable in PLOT columns than in WCOT&nbsp;columns.</p><h3><strong>2. MDCW / University of Copenhagen: One-shot tensor decomposition of full-scale GC×GC-VUV datasets for resolving petrochemical groups</strong></h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_17_Schneide_67c8ff7866.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The presentation introduces a novel <strong>all-samples-at-once, shift-invariant tri-linear tensor decomposition approach</strong> for the analysis of full-scale <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?search=GC%C3%97GC-VUV"><strong>GC×GC-VUV</strong></a><strong> datasets</strong>, aimed at resolving and quantifying petrochemical groups. Traditional template-based or pixel-based methods struggle with retention-time shifts and co-eluting compounds, often requiring manual intervention and prior chemical knowledge. The proposed approach leverages the intrinsic low-rank structure of GC×GC-VUV data to enable robust, automated group-level analysis across multiple samples simultaneously.</p><p>At the core of the method is a <strong>shift-invariant tri-linear model</strong>, conceptually related to PARAFAC and multivariate curve resolution, but extended using frequency-domain (FFT-based) modeling to explicitly account for chromatographic peak shifts. By decomposing the entire dataset in one step, the model provides <strong>accurate estimates of peak landscapes, VUV spectra, and relative peak areas</strong>, while remaining agnostic to retention-time variability. Importantly, the approach requires only a small number of tunable parameters, making it practical for routine use.</p><p>The method was demonstrated on a <strong>case study involving 14 petrochemical gas-oil samples</strong>, including straight-run, hydrotreated, hydroconverted, coker, and light cycle oils. Extracted VUV spectra showed excellent agreement with reference spectra from a VUV spectral database, enabling confident assignment of components to chemical groups such as saturates, olefins, and mono- to poly-aromatics. Quantitative results exhibited <strong>high repeatability (RSD typically 3–9%)</strong> and strong correlation with established template-based reference methods.</p><p>Overall, the work demonstrates that <strong>one-shot, shift-invariant tensor decomposition</strong> provides a powerful and scalable alternative to conventional GC×GC data-analysis strategies. By combining chemical interpretability, robustness to chromatographic shifts, and strong quantitative performance, the approach opens new opportunities for automated, high-confidence group-level analysis of complex petrochemical samples and beyond.</p><h3><strong>3. Shimadzu: Py-Screener Ver. 3: Simultaneously Test for Substances Regulated Under RoHS, TSCA, and POPs</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00949_en_4754e50164.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>In just one analysis, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=Py-Screener"><strong>Py-Screener</strong></a> Ver. 3 can determine levels of phthalate esters, brominated flame retardants (PBBs, PBDEs), PIP (3:1), UV-328, dechlorane plus (DP), short-chain chlorinated paraffins (SCCPs), and medium-chain chlorinated paraffins (MCCPs).&nbsp;</li><li>It can also test for SCCPs and MCCPs by electron ionization (EI) instead of negative chemical ionization (NCI).&nbsp;</li><li>PIP (3:1), UV-328, DP, and SCCPs and MCCPs can be screened without the need for corresponding reference materials.</li></ul><p>Countries and regulatory bodies worldwide are introducing increasingly stringent regulations on the chemical substances used in electronic devices and industrial products. The RoHS Directive and REACH regulations in the EU, the Toxic Substances Control Act (TSCA) in the USA, and the Stockholm Convention on Persistent Organic Pollutants (POPs) are also targeting an increasingly broad range of substances. Therefore, manufacturers are required to accurately identify regulated substances in their products and comply with each regulation. While Py-Screener Ver. 2 can screen for seven phthalate esters and brominated flame retardants, including substances regulated under the RoHS Directive, version 3 can also screen for PIP (3:1), which is regulated under the TSCA, as well as UV328, DP, and SCCPs and MCCPs , which are regulated under the Stockholm Convention on POPs. A list of supported substances isshown in Table 1. This article introduces the simultaneous analysis of multiple regulated substances and a case study of testing specific regulated substances in samples, using Py-Screener Ver. 3.</p><h4><strong>Analysis Process</strong></h4><p>Py-Screener Ver. 3 can determine levels of phthalate esters and brominated flame retardants contained in products in accordance with the international analytical standards IEC62321-8 and IEC62321-3-3. It can also test for specific regulated substances (Table 1) under the same conditions and in the same analysis. In this test, background intensity and instrument sensitivity (S/N) were verified before analyzing samples. These parameters are prescribed by IEC62321-8 to ensure the accuracy of the methods used. Background intensity and instrument sensitivity were determined using a reference material (PN: 225-31003- 91) *1 that consisted of a plastic sheet that was spiked with seven phthalate esters. The results met the criteria for both parameters.</p><p>The testing workflow is shown in Fig. 1. Before testing samples, calibration curves were prepared by analyzing the 1000 mg/kg phthalate ester reference material and polypropylene spiked with brominated flame retardants (ERM-EC591). A hole puncher was used to punch out two discs at a time of the phthalate ester reference material, and a cutter was used to obtain pieces of the other materials. Each material was weighed in a sample cup for analysis. During the analysis of samples, phthalate esters and some of the regulated brominated flame retardants were quantitated using a one-point calibration curve. The remaining brominated flame retardants and specific regulated substances were quantitated using the correction factor database*2 that is included with Py-Screener Ver. 3.</p><h4><strong>Conclusion</strong></h4><p>Py-Screener Ver. 3 successfully determined in samples the concentrations of the regulated substances PIP (3:1), UV-328, DP, and SCCPs and MCCPs. Normally, SCCP and MCCP levels are tested using NCI, but Py-Screener Ver. 3 uses EI. This enables it to test for not only SCCPs and MCCPs but also phthalate esters, brominated flame retardants, and other regulated substances in just one analysis. In addition, by using the relative correction factors linked to DEHP in the phthalate ester reference material, the levels of these regulated substances were determined without the need for the corresponding reference materials. Py-Screener Ver. 3 can also create a screening program that addresses substance restrictions under the RoHS Directive, the US TSCA, and the POPs Convention.</p><h3><strong>4. Thermo Fisher Scientific: Improving low carbon steel production in specialty steel processes</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/prima_pro_process_mass_spectrometer_an1626_7fc840235f.pdf"><strong>Full PDF for download</strong></a></li></ul><p>World crude steel production reached 1,691 million tonnes in 2017, up by 5.3% compared to 2016.1 While much of this capacity is still produced in primary steel processes such as basic oxygen furnaces and electric arc furnaces, the need for refined steel with greater durability and resistance to heat and corrosion has led to the increased use of vacuum degassing processes, such as VOD and RH, in secondary steel production. These processes are able to achieve ultra-low levels of residual carbon, while at the same time retaining desired levels of other alloy materials. If these processes are to achieve the required level of steel product quality, they need fast, continuous gas analysis of the furnace exhaust gas. Without accurate information on the composition of the gas leaving the furnace, any variations in the decarburization process are only detected after the event, resulting in the production of out-of-specification steel.</p><h4><strong>Advantages of mass spectrometry&nbsp;</strong></h4><p>Traditional Non-Dispersive Infra-Red (NDIR) analyzers are used in many conventional steelmaking processes to measure CO and CO<sub>2</sub> , but they can only sample at atmospheric pressure. In vacuum steelmaking the process pressure changes dramatically, typically from atmospheric pressure down to less than 1 mbar, over the 20-30 minutes of the melt. So NDIR analyzers have to sample some distance downstream from the process. Analytical data is updated several minutes after the gas leaves the melt and the control system is forced to operate on historic rather than real-time data.&nbsp;</p><p>Paramagnetic analyzers can be used to measure O<sub>2</sub> , while thermal conductivity analyzers can be used to measure H<sub>2</sub> . These analyzers also suffer from slow response, while the need to operate three different types of analyzers adds to the plant maintenance burden. Moreover, the three analyzers cannot analyze inert gases, so N<sub>2</sub> is calculated by difference, a result that suffers from the sum of the errors of the three analytical techniques.&nbsp;</p><p>Mass spectrometry operates at high vacuum so it is ideal for monitoring vacuum processes. It is also able to monitor all seven components in Table 1 in seconds rather than minutes, ensuring the plant control model is frequently updated with accurate compositional data.</p><h4><strong>Precision of analysis&nbsp;</strong></h4><p>At the heart of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=Prima+PRO+Mass+Spectrometer"><strong>Thermo Scientific™ Prima PRO Mass Spectrometer</strong></a> (MS) is a magnetic sector analyzer which offers unrivalled precision and accuracy compared with other mass spectrometers. Thermo Fisher Scientific manufactures both quadrupole and magnetic sector mass spectrometers; over thirty years of industrial experience have shown the magnetic sector based analyzer offers the best performance for industrial on-line gas analysis.&nbsp;</p><p>Key advantages of magnetic sector analyzers include improved precision, accuracy, long intervals between calibrations, and resistance to contamination. Typically, analytical precision is between 2 and 10 times better than a quadrupole analyzer, depending on the gases analyzed and complexity of the mixture.&nbsp;</p><p>A unique feature of the Prima PRO magnet is that it is laminated. Its analysis times are similar to a quadrupole analyzer, offering the unique combination of rapid analysis and high stability. This allows the rapid and extremely stable analysis of an unlimited number of user-defined gases. The scanning magnetic sector is controlled with 24-bit precision using a magnetic flux measuring device for extremely stable mass alignment.&nbsp;</p><p>The ion source is an enclosed type for high sensitivity, minimum background interference, and maximum contamination resistance. This is a high-energy (1000 eV) analyzer that offers extremely rugged performance in the presence of gases and vapors that have the potential for contaminating the analyzer. Typical performance specifications for the Prima PRO MS are shown in Table 1. Analytical performance is demonstrated by analyzing the calibration bottle over 1 hour following calibration, with an analysis time of just 6 seconds. Standard deviations measured on the calibration cylinder will be equal to or better than the stated values.</p>

News from LabRulezGCMS Library - Week 07, 2026

Article

Events

Application

Academy

Presentation

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in industrial, government and academic laboratories.

Phenomenex

The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

Agilent Technologies

MDPI

LECO

Thermo Fisher Scientific

Wasson-ECE Instrumentation

C&EN

<p><strong>Agilent Raman spectrometers use proprietary spatially offset Raman spectroscopy (SORS) and transmission Raman spectroscopy (TRS) in pharmaceutical raw material verification and quality control.&nbsp;</strong></p><p>SORS enables our Raman spectrometers to analyze through containers and opaque barriers, from helping first responders identify the contents of suspect packages, to high-throughput raw material identification inside unopened packaging at pharmaceutical quality control. TRS nondestructively screens whole tablets and capsules in seconds, for rapid content uniformity and polymorph analysis in pharma QC and formulation development</p><blockquote><p><strong>Presenter: </strong>Yanqia Wang, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)</p><p>Dr. Yanqia Wang started working for Agilent Technologies Inc. as a FTIR application Engineer in 2013, providing pre-&amp;post-sale application support. The products he covers from Bench-top FTIR microscopes to various Mobile FTIR spectrometers. Dr. Wang received his PhD of analytical chemistry from Duke University in 2004, doing dynamic IR spectroscopy research. Then he joined Fitzpatrick Center for Photonics at Duke University, doing Tissue Raman spectrometer instrumentation. Since 2007, Dr. Wang worked for Avery Dennison Corp. as a spectroscopist, providing molecular analytical support to the research &amp; development.</p></blockquote><p>&nbsp;</p>

Agilent Technologies: Raman Spectroscopy for Pharmaceutical Applications

Raman Spectroscopy for Pharmaceutical Applications

Agilent Raman spectrometers use proprietary SORS and TRS in pharmaceutical raw material verification and quality control

<div><div><div><div><div><div><article><div><div><div><div><div><div><p>Explore best practices for sample capture, transport, and introduction to ensure accuracy, integrity, and reliability in analytical workflows and laboratory applications.</p></div></div></div></div></div></div></article><div>&nbsp;</div></div></div></div></div></div></div><blockquote><p><strong>Presenter:</strong> John Wasson</p><p>John Wasson has over 40 years of experience in Gas Chromatography and Chemical Instrumentation. He is President of Wasson-ECE Instrumentation, Inc.</p></blockquote>

Wasson-ECE Instrumentation: Free Webinar Series

Sample Capture, Transport and Introduction

Explore best practices for sample capture, transport, and introduction to ensure accuracy, integrity, and reliability in analytical workflows.

<p><strong>Plastic waste is a growing environmental and industrial challenge, and chemical recycling through pyrolysis is emerging as a pathway to circularity. By converting mixed or contaminated plastics into liquid hydrocarbons, pyrolysis enables their reuse as feedstocks for fuels and new materials. Ensuring process efficiency and product quality requires robust analytical control.</strong></p><p>This session will outline how gas chromatography (GC) solutions support pyrolysis workflows. Topics include characterization of pyrolysis oils, quantification of hydrocarbon fractions, and detection of oxygenates, sulfur, and other contaminants that affect downstream refining. Examples will highlight how analytical testing enables consistent product streams suitable for integration into petrochemical and fuel supply chains.</p><p>By linking process monitoring with circular economy goals, the session will demonstrate how GC workflows help advance scalable solutions for plastic waste conversion.</p><blockquote><p><strong>Presenter: Ms. Phoebe Phan </strong>(<span>Business Development Manager, Agilent Technologies, Singapore)</span></p><p><span>Phoebe joined Agilent Technologies in 2020 as Business Development Manager, and currently is Market Development Specialist focusing on alternative energy segment. Her educational background includes a BS in Applied Chemistry.</span></p></blockquote>

Agilent Technologies: Energy Transition Webinar Series

Plastic Circularity: Pyrolysis and Workflow Solutions

This session will outline how gas chromatography (GC) solutions support pyrolysis workflows.

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Per- and polyfluoroalkyl substances (PFAS) remain one of the most pressing environmental challenges of our time. Their structural diversity, persistence, and presence across complex environmental matrices make them particularly difficult to monitor. Despite their relatively high molecular masses, many PFAS possess sufficient volatility to be analysed by gas chromatography–mass spectrometry (GC–MS), opening new possibilities for both targeted and non-targeted screening.</strong></p><p>In this webinar, Prof. Flavio Franchinaand Marco De Poli (University of Ferrara) will present a dual analytical strategy combining one-dimensional GC and comprehensive two-dimensional GC (GC×GC) coupled with time-of-flight mass spectrometry (TOFMS). By applying multiple ionisation modes—including EI, PCI, and NCI—the workflow enables improved sensitivity and selectivity across different PFAS families.</p><p>A novel dynamic headspace (DHS)–thermal desorption (TD) approach for water samples will also be introduced, providing a robust platform for the detection, characterisation, and quantification of semi-volatile PFAS. Beyond the targeted analysis of known PFAS subclasses, the power of GC×GC-TOFMS allows the identification of other relevant contaminants, making it an indispensable tool for advancing environmental monitoring.</p><p>Join us to discover how these advanced analytical strategies can help you go beyond the target in addressing PFAS contamination and safeguarding our essential resources of air, water, and soil.</p><blockquote><p><strong>Presenter: </strong>Flavio Antonio Franchina (Associate Professor, University of Ferrara)</p><p><strong>Presenter:&nbsp;</strong>Marco De Poli (PhD Student, University of Ferrara)</p></blockquote></div></div></div>

LECO: Beyond the Target: Analytical Strategies for the Non-Targeted Screening of Per- and Poly-Fluorinated Substances by GC-TOFMS

Beyond the Target: Analytical Strategies for the Non-Targeted Screening of Per- and Poly-Fluorinated Substances by GC-TOFMS

 Prof. Flavio will present a dual analytical strategy combining one-dimensional GC and comprehensive two-dimensional GC (GC×GC) coupled with TOFMS.

Non-Targeted PFAS Screening by GC-TOFMS

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Join us for an insightful webinar designed for scientists and quality professionals working in protein synthesis and analysis. Dr. Jan Wuelfken will showcase how to accelerate your workflows and ensure compliance with cutting-edge analytical tools.</strong></p><h4><strong>Key learning objectives:</strong></h4><ul><li>Learn how Vaya Raman Spectroscopy enables rapid, non-destructive raw material identification to support efficient and compliant protein synthesis workflows.</li><li>Discover how the Cary 3500 UV-Vis spectrophotometer delivers high-throughput, precise protein quantification and characterization.</li><li>Gain practical insights into streamlining your analytical processes from raw materials to final protein products.</li></ul><h4><strong>Who should attend?</strong></h4><p>This webinar is tailored for professionals involved in protein synthesis and analysis, including analytical scientists, QC specialists, lab technicians, and researchers in biopharma and biotech. If you're looking to enhance raw material verification and streamline protein quantification workflows, this webinar will serve your needs.</p><blockquote><p><strong>Presenter:</strong> Jan Wülfken (Product Specialist, Raman Spectroscopy, Agilent Technologies)</p><p>Jan Wulfken graduated from the University of Hamburg in 1997, first with a diploma thesis about NMR-based conformation analysis of an antimicrobial peptide, and again in 2001 with his PhD thesis about developing CD4-binding peptides as inhibitors for HIV infection. He joined Varian, inc. in 2001 as a sales representative for molecular spectroscopy. With the acquisition of Varian in 2010 by Agilent, he took over the position of a product specialist for molecular spectroscopy in the Agilent International Distributor Organization (IDO). Today, his responsibility is the full Agilent molecular spectroscopy portfolio, including UV-Vis, UV-Vis/NIR, fluorescence, FTIR, and Raman spectroscopy, in IDO.</p></blockquote></div></div></div>

Agilent Technologies: Optimizing Biomolecular Quality Control - Addressing Manufacturing and Residue Analysis Challenges

UV-VIS and Raman Spectroscopy in BioPharma Protein Analysis

Boost protein analysis efficiency with Agilent’s Raman and UV-Vis tools. Learn to accelerate synthesis workflows and enhance compliance in your lab.

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Join Agilent for an insightful webinar focused on quality control strategies for the release testing of biopharmaceutical drugs in alignment with USP protocols. Three expert speakers will explore critical analytical techniques: (U)HPLC for detecting and characterizing aggregate formation, ICP-MS for quantifying metal impurities, and GC/MS for analyzing residual solvents.&nbsp;</strong></p><h4><strong>Key learning objectives:</strong></h4><ul><li>This session will provide practical guidance and innovative solutions to ensure compliance and product safety in Biopharma QC workflows.</li></ul><h4><strong>Who should attend?</strong></h4><p>Whether you're an analytical scientist, technician, researcher, or quality control specialist, this webinar is designed to empower you with practical insights and cutting-edge techniques. Discover how to streamline your workflows, boost analytical precision, and ensure regulatory compliance. Don’t miss this opportunity to explore integrated solutions that help bring biopharmaceutical products to market—safely, efficiently, and confidently.</p><blockquote><p><strong>Presenter:</strong> Hans Christian Høiberg (HPLC Product Specialist, Agilent Technologies)</p><p>Hans Høibergis a product specialist in liquid chromatography at Agilent and has been working here for the past 6 years. He holds a PhD in Nanoscience from Aarhus University, with a focus on biopharmaceuticals. Hans is passionate about the characterization of biologicals, and is a part of Agilent’s European Biopharma focus team.</p><p><strong>Presenter: </strong>Raimund Wahlen (Atomic Spectroscopy Product Specialist, Agilent Technologies)</p><p>Raimund Wahlen is the atomic spectroscopy product specialist for Agilent Technologies in the UK and Ireland and is actively involved in delivering technology-based solutions to the Li-ion battery market. Before joining Agilent in 2009, Raimund was a self-employed training consultant delivering ICP-MS applications training across EMEA, North America and South Africa. Between 1999 and 2003, Raimund worked as a Research Specialist at LGC Ltd in Teddington, UK with the focus of developing high-accuracy methods for analysis of organometallic species by LC, GC, and ICP-MS, which were used for the certification of new organometallic speciation reference materials.</p><p><strong>Presenter: </strong>Dr. Marion Schäffer (Product Specialist, GC and GC/MS, Agilent)</p><p>Marion Schäffer works as a product specialist for gas chromatography/mass spectrometry at Agilent Technologies in Germany. She has +15years of experience in analytical chemistry, joining Agilent in 2014 as an application engineer for GC/MS.</p></blockquote></div></div></div>

Quality Control in Focus: USP-Aligned Testing for Biopharmaceuticals

Join us for webinar focused on quality control strategies for the release testing of biopharmaceutical drugs in alignment with USP protocols. 

USP-Aligned Testing for Biopharmaceuticals

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Join us for the "Chromeleon Processing Method Masterclass", where we will delve into the intricacies of integration, calibration, and beyond. This webinar is designed for professionals looking to enhance their skills and knowledge in Thermo Scientific Chromeleon software.</strong></p><h4><strong>Topics:</strong></h4><ul><li><strong>Processing method:</strong> Learn how to create, edit, and manage tabs and access with the Chromeleon Processing Method.</li><li><strong>Detection: </strong>Explore integration options beyond Cobra to optimize your detection processes.</li><li><strong>Component table:</strong> Discover tools for creating and managing your component table effectively.</li><li><strong>Calibration: </strong>Understand how to set up, adjust, and manage calibrations for accurate results.</li><li><strong>Subtraction:</strong> Get insights into background subtraction options and setup.<br>Peak tracking: Utilize 3D data to automatically name and track peaks with precision.</li></ul><h4><strong>Why Attend:</strong></h4><ul><li>This masterclass will provide you with comprehensive knowledge and practical skills to leverage Chromeleon software for your analytical needs. Whether you are new to Chromeleon CDS or looking to refine your expertise, this webinar will offer valuable insights and techniques to improve your workflows.</li></ul><p><i>Cannot attend the live broadcast?&nbsp;</i></p><p><i>Please register anyway, and we will automatically send you the link to the recording.</i></p><blockquote><p><strong>Presenter: </strong>Darren Barrington-Light (Senior Manager, Product Marketing, Thermo Fisher Scientific)</p><p>Darren Barrington-Light’s background includes over 25 years of experience in the field of analytical chemistry, chromatography hardware and computer software. Having worked in chromatography throughout his career, Darren has a unique understanding of the requirements of organizations that rely on chromatography data to manage their day to day operations. As capabilities have advanced, he has worked with clients across multiple industries to show them how software solutions can help them to improve their day to day operations and drive fast, informed decisions.</p></blockquote></div></div></div>

Thermo Fisher Scientific: Chromeleon Processing Method Masterclass - From Integration to Calibration and Beyond

Chromeleon Processing Method Masterclass - From Integration to Calibration and Beyond

Join us for Chromeleon Processing Method Masterclass, where we will delve into the intricacies of integration, calibration etc.

Chromeleon Processing Method Masterclass

<p><strong>Product mix-ups don’t announce themselves, but their consequences do. Whether it’s a misidentified raw material, a wrong line transfer, or a product transmix during pipeline transport, these errors can trigger scrapped batches, costly reprocessing, unplanned downtime, hazardous reactions, and serious safety risks. Traditional lab testing often catches these issues too late, after the damage is done.</strong></p><p>In this mini course, experts from HF Sinclair and Metrohm USA will show how inline Raman spectroscopy reduces product identification time from minutes to seconds, delivering measurable ROI and protecting product integrity. Throughout the presentation, you’ll be able to submit your questions, which will be answered during the live Q&amp;A.</p><p>All participants will have the opportunity to receive a certificate of participation. Join us to gain practical strategies and real-world insights. Register today and take the first step toward eliminating costly mix-ups for good.</p><h4><strong>Key Learning Objectives:</strong></h4><ul><li><strong>Understand the hidden risks of product mix-ups:</strong> Learn how errors during unloading, manufacturing, or transport—such as misidentified materials or wrong line transfers—can lead to safety incidents, quality failures, and costly downtime.</li><li><strong>Discover the limitations of traditional lab testing: </strong>See why lab-based methods often catch problems too late, and how inline Raman spectroscopy enables faster, more proactive detection—before consequences escalate.</li><li><strong>Identify where inline Raman fits in your operations:</strong> Whether you're in chemicals, pharma, energy, or manufacturing, learn how this technology supports product integrity, safety compliance, and cost control across your process streams.</li></ul><h4><strong>Who Should Attend:</strong></h4><ul><li><strong>Production and operations leaders</strong> – including Production Managers, Plant Managers and Operational Managers</li><li><strong>Technical and quality experts </strong>– such as Process Engineers, Quality Control Specialists and Automation &amp; Control Engineers</li><li><strong>Safety and compliance professionals</strong> – including EHS Managers, Safety Officers and Compliance Specialists</li><li><strong>Strategic decision-makers</strong> – such as Project Leads and Technical Stakeholders</li></ul><blockquote><p><strong>Presenter: </strong>Kyle Rasmussen (Quality Assurance Lead, HFSinclair Midstream)</p><p><strong>Presenter:&nbsp;</strong>Teresa Alleman (Product Quality, HFSinclair)</p><p><strong>Presenter:&nbsp;</strong>Elena Hagemann (Product Manager, Process Spectroscopy, Metrohm USA)</p><p><strong>Presenter:&nbsp;</strong>Alexandra Taylor (Contributing Editor, C&amp;EN Media Group)</p></blockquote>

Metrohm: Inline Raman: Avoid the Million-Dollar Product Mix-Up

Inline Raman: Avoid the Million-Dollar Product Mix-Up

Discover how inline Raman spectroscopy prevents product mix-ups, improves safety, and cuts costs with rapid material identification

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>In semiconductor manufacturing, even the smallest impurity can destroy wafers, disrupt production, and cost millions. As fabs push to produce smaller, faster, and more powerful chips, the need to ensure that ultra-high purity (UHP) gas is used during production has never been more critical. Traditional techniques like gas chromatography and spectroscopy can’t keep pace with today’s demands for speed, accuracy, and parts-per-trillion (ppt) sensitivity.</strong></p><p>Join Thermo Fisher Scientific and Dan Merriman, Senior Advisor - Process Analyzers, as we introduce the APIX δQ and APIX Quattro mass spectrometers. These next-generation solutions combine Atmospheric Pressure Ionization Mass Spectrometry (API-MS) with advanced calibration and software to deliver unmatched performance when assessing gas supplies. In this session, you’ll learn how leading fabs are transforming their quality control workflows, protecting every wafer, and meeting the most stringent industry standards with confidence.</p><h4><strong>Here are some key learnings you'll take from this webinar:</strong></h4><h5><strong>Why ultra-high purity gas analysis is essential to yield</strong></h5><ul><li>Discover how trace impurities can cause wafer scrap, downtime, and revenue loss—and why ppt-level gas analysis is critical to protecting production.</li></ul><h5><strong>The advantages of APIX δQ and APIX Quattro mass spectrometers</strong></h5><ul><li>Learn how Thermo Scientific’s APIX analyzers deliver ultra-fast two-minute cycle times, ppt sensitivity, and multi-gas capability—replacing multiple instruments with one integrated solution.</li></ul><h5><strong>Steps to confidently transition to API-MS</strong></h5><ul><li>Explore how to implement APIX systems and streamline calibration with integrated gas processors.</li></ul><h5><strong>How APIX technology aligns with the future of semiconductor QC</strong></h5><ul><li>See how API-MS supports automation, continuous monitoring, and next-generation industry standards, helping fabs safeguard reliability in a fast-evolving market.</li></ul><p><i>Register today to join us for this insightful webinar so you can keep your semiconductor production in top shape.</i></p><blockquote><p><strong>Presenter: </strong>Dan Merriman (Senior Advisor - Process Analyzers, Thermo Fisher Scientific)</p><p>Dan Merriman is a global leader in process analytics and instrumentation with more than 30 years of experience advancing technologies that protect critical industries. At Thermo Fisher Scientific, he has guided worldwide sales, marketing, and product strategy. Recognized for his depth of expertise, Dan has authored numerous white papers and application notes and conducted extensive research that has influenced industry standards in monitoring and measurement.</p></blockquote></div></div></div>

Thermo Fisher Scientific: Every Wafer Counts: How ppt-Level Gas Analysis Safeguards Semiconductor Production

Every Wafer Counts: How ppt-Level Gas Analysis Safeguards Semiconductor Production

Discover how APIX mass spectrometers enable ppt-level UHP gas monitoring, prevent wafer loss, and enhance semiconductor QC with fast, reliable API-MS analysis.

Protect Semiconductor Production with ppt-Level Gas Analysis

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h5><strong>Welcome from the Chair</strong></h5><h5><strong>5th</strong><i><strong> Separations</strong></i><strong> Webinar</strong></h5><h5><strong>(Young Scholars Workshop) Metric Tools for the Evaluation of Chromatographic Methods</strong></h5><p>In 1998, Paul Anastas and John Warner were the pioneers who coined the term “Green Chemistry”, as a result of high concern for human health and the protection of the environment from exposure to hazardous chemicals. Since then, many metric tools have been proposed to evaluate the green character of an analytical method. However, soon after, analytical chemists realised that greenness is not the only criterion to be taken into consideration when selecting an analytical method. The consideration of other parameters, such as the type of analysis, the number of compounds that can be determined in one run, the analytical technique and required instrumentation, the throughput, the commercial availability of reagents, the automation degree, the need for pre-concentration to meet legislation criteria, etc., is also essential. Therefore, the practicality and applicability of these approaches are also to be taken into account. Moreover, the analytical performance and innovation grade should, in the meantime, be evaluated using metric tools. The principles and the relevant indices will be described in the webinar, while the software and its application will be demonstrated.</p><h4><strong>Registration</strong></h4><blockquote><p class="cke-user_style-important"><a target="_blank" rel="noopener noreferrer" href="https://us02web.zoom.us/webinar/register/8017635192887/WN_6K8Eez0xQUOs3ccK3j0NLQ#/registration"><strong>Register here</strong></a></p></blockquote><p><strong>This is a FREE webinar.</strong> After registering, you will receive a confirmation email containing information on how to join the webinar. <strong>Registrations with academic institutional email addresses will be prioritized</strong>.</p><p>Certificates of attendance will be delivered to those who attend the live webinar.</p><h4><strong>Program</strong></h4><h5><strong>2:00 – 2:10 pm Chair Introduction</strong></h5><ul><li>Prof. Dr. Victoria Samanidou</li></ul><h5><strong>2:10 – 2:30 pm Complementing Greenness Evaluation in White Analytical Chemistry: The Roles of the Blue Applicability Grade Index for practicality evaluation</strong></h5><ul><li>Dr. Natalia Manousi&nbsp;</li></ul><h5><strong>2:30 – 2:50 pm Meet “VIGI”: A New Survey-Based Metric to Assess Innovation in Analytical Chemistry Methods</strong></h5><ul><li>Dr. Adrián Fuente-Ballesteros</li></ul><h5><strong>2:50 – 3:10 pm How Red Analytical Performance Index can be used to assess methods in terms of analytical performance: Theory and Applications</strong></h5><ul><li>Dr. Natalia Manousi</li></ul><h5><strong>3:10 – 3:30 pm Introducing “GLANCE”: A Graphical Layout Tool for Analytical Chemistry Evaluation</strong></h5><ul><li>Dr. Adrián Fuente-Ballesteros</li></ul><h5><strong>3:30 – 4:00 pm Q&amp;A</strong></h5><h5><strong>4:00 – 4:10 pm Closing of Webinar</strong></h5><ul><li>Prof. Dr. Victoria Samanidou</li></ul><blockquote><p><strong>Event Chair:</strong> Prof. Dr. Victoria Samanidou (Laboratory of Analytical Chemistry, School of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece)</p><p><strong>Keynote speaker: </strong>Dr. Natalia Manousi (Institute of Chemical Technologies and Analytics, TU Wien, Vienna, Austria)</p><p><strong>Keynote speaker: </strong>Dr. Adrián Fuente-Ballesteros (Analytical Chemistry Group (TESEA), I. U. CINQUIMA, Faculty of Sciences, University of Valladolid, Valladolid, Spain)</p></blockquote></div></div></div>

Sciforum: (Young Scholars Workshop) Metric Tools for the Evaluation of Chromatographic Methods

(Young Scholars Workshop) Metric Tools for the Evaluation of Chromatographic Methods

Learn how new metric tools assess greenness, practicality, performance, and innovation in chromatographic methods at the 5th Separations Webinar.

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