EU Regulation 396/2005: Pesticide Residue Testing and the Critical Role of QuEChERS Evaporation in Food Safety

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 4th May 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you application note by Shimadzu, presentation by MDCW / JEOL and technical note by Thermo Fisher Scientific!<h3>1. MDCW / JEOL: Flow-Modulated GCxGC-QMS Analysis Without Splitting Off the GC Flow</h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_16_Jensen_11e29d5022.pdf">Full PDF for download</a></li></ul><section><div><div><div><div><div><div>This presentation by Kirk Jensen (JEOL USA) explores the feasibility of performing flow-modulated comprehensive two-dimensional gas chromatography (GC×GC) coupled with quadrupole mass spectrometry (QMS) without splitting the GC flow, which is traditionally required to protect MS systems from high carrier gas flows. The core concept builds on GC×GC, where compounds are separated using a primary and secondary column connected via a modulator, significantly increasing separation power compared to one-dimensional GC. The presentation contrasts thermal modulation (offering sharper peaks and higher theoretical sensitivity but requiring cryogenic cooling) with flow modulation, which avoids cryogens, handles volatile analytes well, and is more flexible, but typically demands higher gas flows that standard MS systems cannot tolerate .To address this limitation, the study utilizes the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=24&amp;search=JMS-Q1600GC">JEOL JMS-Q1600GC</a> UltraQuad quadrupole GC-MS system, which can accept unusually high carrier gas flows (up to ~20 mL/min), enabling direct coupling with a SepSolve INSIGHT flow modulator without splitting the effluent . The analytical setup includes dual GC columns (e.g., Zebron ZB-5MSplus for the first dimension and BPX50 for the second), high secondary flow rates (~25 mL/min), and electron ionization (EI) MS detection. Additional system components include optional FID detection, bleed line control, and ChromeSpace software for data processing . This configuration allows full analyte transfer into the MS, eliminating the need for flow splitting and potentially improving detection efficiency.Experimental results demonstrate the applicability of this approach to complex mixtures, including a pesticide mixture containing over 200 compounds and real-world samples such as perfumes and fuels. The GC×GC-MS system produced detailed two-dimensional chromatograms with high spectral quality, enabling the correct identification of approximately 120 compounds despite relatively moderate spectral match factors . Comparisons at different flow rates (e.g., 25 vs. 50 mL/min) showed that spectral integrity and compound identification remain robust, indicating that higher flow operation does not significantly compromise MS performance.In conclusion, the work demonstrates that flow-modulated GC×GC-QMS without flow splitting is feasible, provided that the MS system can tolerate high carrier gas flows. While further optimization is needed (e.g., column selection, inlet pressure, and separation conditions), the approach offers a practical alternative to thermal modulation by eliminating cryogens and simplifying operation. Future work will focus on improving sensitivity, optimizing separations, and exploring alternative carrier gases such as hydrogen to reduce costs and expand applicability</div></div></div></div></div></div></section><h3>2. Shimadzu: Detailed Hydrocarbon Analysis by Nexis GC-2030 Using ASTM D6730</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00863_en_eb633bc741.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>Detailed compositional analysis of gasoline in accordance with ASTM D6730 is feasible using the Nexis GC-2030.&nbsp;</li><li>By employing PONAsolution, a PONA/DHA analysis software, laborious identification tasks can be reduced, and quantitation calculations and report generation can be performed automatically.</li></ul>ASTM D6730 specifies the analysis of hydrocarbons in gasoline and oxygenates such as ethanol, methyl tert-butyl ether (MTBE), and ethyl tert-butyl ether (ETBE) over a boiling point range up to 225 ̊C. Identification and quantification of individual compounds in gasoline are critically important for refinery process control and product quality assurance. In this application news, we report compositional analysis of gasoline conforming to ASTM D6730 using the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexis+GC-2030">Nexis GC-2030 gas chromatograph</a>. Gasoline typically comprises over 100 hydrocarbons, making identification tasks highly complex; however, PONAsolution, a PONA/DHA analysissoftware,simplifies this process.<h4>PONAsolution</h4>PONAsolution Ver.6 provides retention index libraries for each relevant standard (ASTM D6730, D6729, D5134, D6733). Identification of n-alkanes automatically corrects the retention times of the remaining several hundred components, thus streamlining the identification process. When only a specific retention region requires adjustment, the two-point identification function is useful (Fig. 1). In the two-point identification procedure, reference and sample chromatograms are compared while assigning corresponding peaks. First, click on an identified component mark in the reference data (Fig. 1, a), then click the matching sample peak (Fig. 1, b). Repeat this for a second pair of peaks. The retention times of components between these two anchor points are then automatically corrected.<h4>Conclusion</h4>Compositional analysis of gasoline in accordance with ASTM D6730 was performed. The combination of SH PONA Tuning Column and SH-1 PONA main column enabled separation of compounds with closely spaced retention times. Moreover, use of PONAsolution software greatly simplifies complex identification tasks.<h3>3. Thermo Fisher Scientific: Fiber optic probes add flexibility to Raman chemical analysis</h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/drx3_flex_tech_note_tn54708_bebb56b870.pdf">Full PDF for download</a></li></ul>Fourier Transform Infrared Spectroscopy (FTIR) and Raman Spectroscopy are non-destructive analytical techniques that rely on the interaction of electromagnetic radiation with molecular vibrations to provide information about the chemical composition and structure of a sample. Despite their similarities, there are some distinct differences between the two techniques. In principle, FTIR is based on the absorption of infrared radiation by molecules and measures changes in dipole moment during molecular vibrations. Raman spectroscopy, on the other hand, is based on the inelastic scattering of monochromatic light and measures changes in polarizability during molecular vibrations.&nbsp;When applied to bulk chemical analysis, both FTIR and Raman spectroscopy can be used to analyze solids, liquids, and gases, but the nature of Raman spectroscopy lends some unique sampling advantages. Additionally, Raman often requires little to no sample preparation. Presented herein are application examples that highlight some of the sampling advantages of Raman spectroscopy. All the spectral data in this technical note were collected using a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2238">Thermo Scientific™ DXR3 Flex Raman Spectrometer</a> equipped with a fiber optic probe. (Fiber optics are readily available for Raman spectroscopy because of the use of visible and NIR light and do not require the exotic materials associated with FTIR fiber optics.) Preliminary tests for all samples were carried out using both 532 nm and 785 nm excitations, and it was determined that the 785 nm laser set gave an overall better balance between fluorescence and Raman scattering efficiency.<h4>Summary&nbsp;</h4>In this technical note, the analyses of a variety of samples by Raman spectroscopy are demonstrated. All samples were analyzed without sample preparation.&nbsp;<ul><li>Precise and localized analysis at the focal point of the Raman-exciting laser allows sampling through glass bottles, blister packaging and plastic containers, which eliminates possible cross contamination and analyst exposure to hazardous materials. The contributions from the packaging and containers depend on the type of container material, the container thickness, and the materials’ chemical compositional complexity, but these contributions can be readily subtracted out when needed.&nbsp;</li><li>Water is a weak Raman scatterer. Raman therefore has reduced water sensitivity, making it a preferred technique for aqueous solution analysis over FTIR. As demonstrated in the analysis of an energy drink, the Raman bands from water can be subtracted from the spectrum of the aqueous solution, leading to the identification of the components of the solution.&nbsp;</li><li>Raman spectroscopy is well suited for the analysis of inorganic materials, especially in identifying the crystal phases and polymorphs, as demonstrated by the analyses of minerals and pigments in a painting.&nbsp;</li><li>Fiber optic probes provide flexibility and ease of maneuverability. This is particularly advantageous when analyzing samples that are difficult to access or manipulate, such as large containers, geological samples and paintings</li></ul>The DXR3 Flex has multiple sampling options available. A properly configured fiber-optic probe is arguably the most versatile accessory for the analysis of bulk solids and liquids. The advantages, both from those inherent to Raman spectroscopy and those resulting from the use of fiber optic probe, provide opportunities for a wide variety of different applications when using the DXR3 Flex Raman Spectrometer.

News from LabRulezGCMS Library - Week 19, 2026

🎤Francis Femi OloyIn this episode of Concentrating on Chromatography, David speaks with Francis Femi Oloy about using chromatography to uncover hidden pollutants in real-world water systems.Femi’s team analyzed polychlorinated biphenyls (PCBs) in six major rivers in southwestern Nigeria — compounds that were banned decades ago but still persist in the environment. Using a workflow that many analytical labs will recognize — liquid–liquid extraction, cleanup, rotary evaporation, nitrogen blowdown, and GC-ECD detection — they quantified 25 PCB congeners at trace levels and linked the results to ecological and human health risk.<h4>In this conversation, we cover:</h4><ul><li>Why legacy pollutants like PCBs still show up today</li><li>Choosing GC-ECD vs LC-MS for halogenated compounds</li><li>Liquid–liquid extraction and matrix cleanup strategies</li><li>Why sample concentration is critical for dilute environmental samples</li><li>How rotovap + nitrogen blowdown work together without losing volatile analytes</li><li>Seasonal trends (why wet season levels were higher)</li><li>Translating concentration data into meaningful risk assessments</li></ul><h3>Video Transcription</h3><section><div><div><div><div><div><div>Persistent organic pollutants such as polychlorinated biphenyls (PCBs) remain a significant environmental concern despite decades of regulatory restrictions. In this interview, Francais Femi Oloy discusses the environmental and analytical challenges associated with monitoring PCB contamination in rivers of southwestern Nigeria, a rapidly industrializing region where urban growth, industrial activity, agriculture, and dense populations intersect with extensive aquatic systems.Oloy explains that his interest in environmental contaminant analysis emerged from observing unexplained health problems and environmental degradation while growing up in Nigeria. This motivated his transition into organic and environmental chemistry, with a focus on identifying pollutants present in drinking water, agricultural soils, and food systems. Southwestern Nigeria, particularly the Lagos region, represents a critical environmental monitoring area due to intense industrial development, shipping activity, and widespread human dependence on rivers for domestic use, agriculture, and fishing.Although PCBs are considered “legacy pollutants” and are no longer intentionally produced, the interview highlights why they continue to persist in aquatic environments. Old electrical transformers and aging industrial equipment still contain PCB residues, while historical contamination stored in river sediments can become remobilized during flooding, dredging, or sediment disturbance. Because PCBs are hydrophobic and resistant to degradation, they preferentially accumulate in sediments and bioaccumulate through aquatic food chains, creating long-term environmental and human exposure risks.A major focus of the discussion centers on the analytical workflow used for PCB determination in environmental water samples. Composite river water samples were collected in amber glass bottles to avoid contamination and photodegradation, preserved with sodium azide to minimize microbial activity, and stored under cooled conditions prior to extraction. The analytical protocol employed liquid–liquid extraction using dichloromethane (DCM) and hexane to recover both polar and nonpolar PCB congeners. Oloy emphasizes that liquid–liquid extraction was selected over solid-phase extraction (SPE) because of concerns about congener retention within sorbent materials and clogging issues associated with large-volume environmental samples.Following extraction, concentration and cleanup represented critical analytical stages due to the trace-level occurrence and volatility of PCBs. Silica and alumina cleanup procedures were used to remove matrix interferences prior to instrumental analysis. The concentration workflow combined rotary evaporation for bulk solvent reduction with nitrogen blowdown for final volume reduction to less than 1 mL, while carefully avoiding excessive temperature or complete dryness to minimize analyte loss. Oloy repeatedly stresses that improper concentration procedures are among the most common causes of analytical failure in PCB analysis.For instrumental determination, the study utilized gas chromatography coupled with electron capture detection (GC-ECD) rather than LC-MS or GC-MS. According to Oloy, GC was preferred because PCBs are sufficiently volatile for gas chromatographic separation, while ECD provided superior sensitivity and selectivity for chlorinated compounds at environmentally relevant concentrations. The interview also discusses analytical validation strategies, including the use of surrogate standards to assess recoveries, which ranged from approximately 85% to 114%, and signal-to-noise-based determination of detection limits.The study further examined seasonal variations in PCB concentrations, revealing higher levels during the wet season. This observation was attributed to rainfall-driven runoff from contaminated infrastructure, sediment resuspension, and lower temperatures that reduce volatilization losses. To communicate toxicological relevance beyond simple concentration reporting, the researchers also calculated toxic equivalency values (TEQs), converting mixtures of PCB congeners into biologically meaningful toxicity estimates comparable to dioxin toxicity metrics.Beyond environmental monitoring, Oloy highlights broader research interests focused on pollutant remediation and sustainable environmental protection. His group is also involved in developing catalytic materials capable of degrading or removing persistent contaminants from environmental systems. Throughout the discussion, he emphasizes that analytical chemistry plays a central role not only in detecting pollutants, but also in enabling prevention, remediation, and long-term environmental management strategies.</div></div></div></div></div></div></section><blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

Tracking Toxic PCBs in River Water using Gas Chromatography–Electron Capture Detection

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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Metrohm

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Agilent Technologies

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Waters Corporation

<h4>The Waters 2024 Virtual Summer School - An Educational Journey to Master Food &amp; Environmental Analysis</h4>Unlock the full potential of LC-MS techniques with our immersive and educational sessions at the Waters Virtual F&amp;E Late Summer School 2024. From September 24th to 26th, engage with leading experts and discover cutting-edge methods for environmental and food analysis.<h5>Why attend?</h5><ul><li>Comprehensive Learning: Dive deep into advanced LC-MS techniques and gain practical knowledge to enhance your laboratory's analytical capabilities.</li><li>Expert Insights: Learn from industry leaders and gain firsthand experience through detailed modules on chromatography, mass spectrometry, and sample preparation.</li><li>Regulatory Compliance: Stay ahead with the latest insights on EU regulations for PFAS analysis in food and water, ensuring your lab meets stringent standards.</li></ul><h3>Episode #6: Automated Sample Preparation | F&amp;E Summer School - Day 2 - Module 2</h3>This Module builds on the previous one by adding automation to the sample preparation methods. The Andrew+™ pipetting robot offers fully automated liquid handling using electronic pipettes and labware holders called Dominos for a full walk-away automation solution.Creating the connected laboratory, Andrew+ is part of the OneLab™ ecosystem, executing laboratory protocols designed in OneLab software. This flexible architecture enables you to effortlessly transition from laborious manual pipetting procedures to error-free, fully-robotized lab workflows – without any knowledge of programming, laboratory robotics or automation engineering. and explains processes the Andrew+ pipetting robot can take over in your lab.The European Union has adopted Commission Recommendation (EU) 2022/1431 to monitor PFAS in fruits, vegetables, milk and baby food. To achieve quantification at lowest levels of PFAS in food matrices, sample preparation is required which comprise of many pipetting steps and can be time-consuming and error prone. We will demonstrate an automate workflow for the analysis of PFAS in milk using a pipetting robot and stacked dual-phase SPE cartridges to meet EU 2022/1431 levels.<h5>What you'll learn:</h5>Possibilities to automat liquid handling processes in LC and LC-MS e.g.<ul><li>Serial dilution</li><li>Calibration curve</li><li>Solid Phase Extraction (SPE)</li></ul><blockquote>Presenter:&nbsp;Xavier Rodríguez (Business Development Manager Chemistry Group, Southern Europe, Waters)Xavier is part of the European Market Development Team. He works as an Application Specialist with focus on sample prep and has more than 20 years of experience in solving sample prep challenges.Presenter:&nbsp;Daniel Ng PhD (Principal Scientist, Waters Corporation)Daniel Ng received his PhD from the University of Manchester in mass spectrometry proteomics. He worked for 5 years at the Waters mass spectrometry headquarters in Wilmslow, UK, as a service support development engineer specializing in mass spectrometry instrumentation. In 2019, he took up a new role as a principal scientist at the International Food and Water Research Centre (Waters) in Singapore focusing on using advanced instrumentation to answer analytical challenges in the food and water industry. Since 2023, Daniel has lead the Food, Environmental and Material Science Analytical Professional Service team in the Asia-Pacific Region, developing analytical solutions to meet key challenges that customers face.</blockquote>

Waters Corporation: The Waters 2024 Virtual Summer School

Automated Sample Preparation

The Andrew+™ pipetting robot offers fully automated liquid handling using electronic pipettes and labware holders.

This session will provide a comprehensive introduction to the user interface, ensuring you can navigate with ease. Discover the various acquisition modes available and learn how to select the best one for your specific application.Additionally, we will explore the innovative Intelligent Reflex feature, highlighting its benefits in boosting your productivity.Whether you’re new to MassHunter or looking to refine your skills, this webinar is designed to enhance your understanding and efficiency.<blockquote>Presenter: Christian Hegmanns (Application Specialist LC/MS, Agilent Technologies, Waldbronn, Germany)Christian Hegmanns is a state-certified food chemist and works at Agilent as an LC/MS application specialist.With over 10 years of experience in the field of instrumental analysis, Christian develops customer-oriented solutions for a variety of applications with a focus on food analysis.</blockquote>

Agilent Technologies: MassHunter Masterclass Months

MassHunter Acquisition Q-TOF Part I – Basic Overview

Join us for an insightful webinar where we delve into the essentials of MassHunter Acquisition Q-TOF. 

This webinar will guide you through optimizing your Q-TOF for superior data quality by selecting the most suitable tune mode for your samples.We will delve into various MS acquisition modes, including MS only, All Ions (QRAI), Auto MS/MS (directed MS/MS; targeted MS/MS), and PRM mode.Learn how to fine-tune method settings to enhance your data quality and achieve the best analytical results. Whether you’re a seasoned user or new to QTOF, this session will provide valuable insights to elevate your mass spectrometry.<blockquote>Presenter: &nbsp;Stefan Schaebler (Application Specialist LC/MS, Agilent Technologies)Stefan completed his PhD in Biology, specializing in LC-MS-based lipidomics and metabolomics. Following his doctoral studies, he joined Agilent Technologies as an LC/MS Application Specialist. In this role, Stefan focuses on small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</blockquote>

MassHunter Acquisition Q-TOF Part II – Advance Settings

Join us for an in-depth exploration of advanced settings in MassHunter Acquisition for Q-TOF systems.

We’ll explore how outlier setup can help you focus on samples and compounds that require your attention, ensuring accurate and reliable results.Additionally, you’ll learn how viewing compounds and calibration at a glance can expedite data review, making the process faster and more intuitive.Finally, we’ll demonstrate how easily you can summarize your results in comprehensive reports or export them to Excel, streamlining your workflow and enhancing productivity.Don’t miss this opportunity to enhance your data analysis skills with MassHunter Quant!<blockquote>Presenter: Peter Kornas (LC/MS Applikationsspezialist, Agilent Technologies)Peter Kornas has more than 10 years of experience in the development and validation of analytical methods for the determination of pesticides, mycotoxins and contaminants using LC/MS/MS. Before joining Agilent as an LC/MS application specialist in 2018, he worked as an analytical chemist in the food industry. During this time, he was responsible for the development and validation of analytical methods and worked in close coordination with Regulatory Affairs to ensure compliance with the legal requirements of the LC/MS method portfolio.</blockquote>

MassHunter Quant – A Fast and Easy Way from Data to Results

Join us and discover how quickly a quantitation method can be set up, enabling efficient data processing.

Join us for an insightful webinar where we will explore the critical aspects of differentiating good from bad data and how this distinction can significantly influence your results. From screening to quantification, discover the value of targeted data analysis workflows using non-targeted data with our innovative software and hardware.Find by Formula algorithm. Learn to identify the most suitable MS/MS approach for your experiments, initiate quantitation for your compounds of interest, and incorporate retention times (RTs) and MS/MS spectra into a custom database and library.This session is designed to enhance your understanding and application of Q-TOF data analysis, ensuring robust and reliable outcomes.<blockquote>Presenter: Hannah Florance (Agilent Technologies)Hannah has had multiple roles in the life sciences, starting as a protein chemist, before moving into proteomics and then metabolomics. A major part of her time working in academia involved running LC and GCMS core facilities supporting projects ranging from synthetic biology to cancer research. She is currently an LCMS applications specialist for Agilent. Presenter: Stefan Schaebler (Application Specialist LC/MS, Agilent Technologies)Stefan completed his PhD in Biology, specializing in LC-MS-based lipidomics and metabolomics. Following his doctoral studies, he joined Agilent Technologies as an LC/MS Application Specialist. In this role, Stefan focuses on small molecule applications using LC-QTOF, with a strong emphasis on software tools and data interpretation.</blockquote>

MassHunter Qual – The Solid Pillar in Q-TOF Data Analysis

We will explore the critical aspects of differentiating good from bad data and how this distinction can significantly influence your results.

Join our upcoming webinar on the MassHunter Quant Screener Tool to discover how to harness the power of quantitative analysis for effective screening and identification of potential suspect compounds.This session will provide in-depth guidance on creating methods from PCDL databases, evaluating result parameters, and generating straightforward summary reports. Additionally, learn how retention time (RT) prediction can enhance your screening process by significantly accelerating and simplifying large database searches.Don’t miss this opportunity to elevate your analytical capabilities!<blockquote>Presenter: &nbsp;Jonathan Spencer (Application Specialist, Agilent Technologies)Jonathan studied BSc Natural Sciences at the University of Nottingham and later went on to Sheffield Hallam University to study a MSc in Forensic Science.Following graduation, he spent 2 years as a Confirmatory Analyst in an anti-doping and forensic toxicology lab, before joining Agilent as an LC/MS Applications Scientist. At Agilent, he focuses on small molecule applications using LC/TQ and LC/Q-TOF in fields of like food, forensic and environmental analysis.</blockquote>

MassHunter Quant Screener Tool

Discover how to harness the power of quantitative analysis for effective screening and identification of potential suspect compounds. 

We kindly invite you to join us for this live webinar: An Introduction to Nanoscale Infrared Spectroscopy and Imaging with Photothermal AFM-IR. Infrared (IR) spectroscopy is a commonly used characterization technique for organic materials and many inorganic compounds and crystals. While powerful, it is limited by the diffraction limit to resolution on the order of several microns, and the lateral resolution is strongly dependent on the wavelength. Photothermal AFM-IR&nbsp;is a novel technique which offers IR spectroscopy and imaging on materials with a lateral resolution 1000x better than traditional FTIR and &lt;1 nm detection sensitivity with model-free interpretation. AFM-IR achieves this by using an AFM probe as the detector of photothermal expansion. This opens a variety of applications on both organic and inorganic materials where nanometer sensitivity and resolution are key.<div> In this webinar we will:</div><ul><li>Introduce the photothermal AFM-IR technique</li><li>Explore the surprisingly simple mechanism underlying the technique</li><li>Highlight a few of its many broad applications</li><li>Offer a demonstration of photothermal AFM-IR on the Dimension IconIR system</li></ul><blockquote>Presenter: Peter De Wolf, Ph.D., (Director of Technology &amp; Application Development)Peter De Wolf is director for AFM technology &amp; application development at Bruker Nano Surfaces, covering all applications related to Scanning Probe Microscopy (SPM). He obtained his PhD from IMEC, Belgium on the development of new SPM methods for 2D carrier profiling in semiconductors and has more than 25 years of experience on SPM. He is the author and co-author of over 30 publications related to electrical characterization using SPM. He also owns several SPM patents, and developed several new SPM modes for electrical characterization.Presenter: Cassandra Phillips, Ph.D. (Application Scientist, Bruker)Cassandra did her Ph.D. at the University of Toronto exploring the photophysics of boron nitride nanotubes using scattering scanning nearfield optical microscopy (s-SNOM) and computational models. She has been working at Bruker Nano Surfaces and Metrology since September 2019 as an Applications Scientist focusing on nanoscale IR spectro-microscopy and other correlated imaging techniques realized with atomic force microscopy.Presenter: Dr. Qichi Hu, (Senior Applications Scientist )Qichi is currently a Senior Staff Applications Scientist at Bruker Nano. He received a bachelor’s degree from Peking University and Ph.D. from University of British Columbia. He then did postdocs in U.S. university and national labs. Qichi has been working on nanoIR development and applications for over a decade, at Anasys and now at Bruker.</blockquote>

Bruker: Introduction to Nanoscale Infrared Spectroscopy and Imaging with Photothermal AFM-IR

Introduction to Nanoscale Infrared Spectroscopy and Imaging with Photothermal AFM-IR

An Introduction to Nanoscale Infrared Spectroscopy and Imaging with Photothermal AFM-IR.

Nanoscale IR Spectroscopy / Imaging with Photothermal AFM-IR

Just one analysis for multiple chemical and physical parameters – Near-Infrared Spectroscopy (NIRS) is a fast and highly efficient solution to consolidate your quality control to a single analytical method.In our upcoming webinar on November 7, Maria Cartez and Andreas Agerer, Product and Application Specialists NIRS at Metrohm International Headquarters, will give you a brief introduction to NIRS. They will then show you how this technology can be combined with robotic sampling to maximize sample throughput in a fully automated workflow. Next, they will show you how your titrations can also be integrated, making this platform approach a multi-method solution for your daily routine analysis.In the final part of the webinar Maria and Andreas will present application examples from different industries, such as multi-parameter analysis in edible oils and moisture content in lyophilized pharmaceutical samples, to illustrate the benefits of automated NIRS analysis.Register now for this virtual event; we are looking forward to welcome you!Key learnings of this webinar:<ul><li>Near-Infrared Spectroscopy - how does it work?</li><li>How to maximize sample throughput using latest automation solutions</li><li>Examples of NIRS automation applications for the analysis of foodstuffs, chemicals, and pharmaceuticals</li><li>How to consolidate your titrations and NIR parameters to a single platform</li></ul>Who should attend?Lab managers, lab technicians, QC managers, chemists.<blockquote>Presenter: Maria Cartes (Product Specialist Spectroscopy, Metrohm International Headquarters)Dr. Maria Cartes studied chemistry. After finishing her PhD studies on ethylene polymerization at the University of Seville (Spain), she moved to Switzerland to work as a postdoc. In 2021, Maria joined Metrohm where she works as Product Specialist in the Competence Center Spectroscopy, providing international support and product training for NIRS.Presenter: Andreas Agerer (Application Specialist NIRS, Metrohm International Headquarters)Andreas Agerer is an Application Specialist at Metrohm AG, working in the Competence Center Spectroscopy since 2018. In this time, he has been responsible for developing NIRS methods tailored to new application areas and supporting sales teams during feasibility studies. Andreas completed his university graduate work in the field of polymer analysis using vibrational spectroscopy.</blockquote>

Metrohm: Transfrom your QC Workflow: Near-Infrared Spectroscopy meets Automation

Transform your QC Workflow: Near-Infrared Spectroscopy meets Automation

We will give you a brief introduction to NIRS and show you how this technology can be combined with robotic sampling

Near-Infrared Spectroscopy meets Automation

Following up from our very successful previous sessions, we are delighted to offer another panel discussion in the ever-popular “Ask the Agilent Experts” series.Have you ever had a question about your GC/GCMS analysis and thought, “I have no idea what to do,” or that since the question seemed so simple, everyone must already know the answer and “Am I the only one who doesn’t know what to do?” We can assure you that you are not alone.If you have a question, we can guarantee that you are not the first…nor the last person to ask the question, especially when it comes to gases. Sometimes the simplest of questions can have the most complex answers. A question about the leaks on your mass spectrometer can lead to a discussion about how gas quality impacts sensitivity. A question about what to do when converting a method from helium to hydrogen carrier gas can lead to a discussion about column dimensions, column bleed, and what thermal stability means. There’s no such thing as an easy answer because the answer always depends on many different factors.Experts from Agilent, as well as from the field, will discuss some of the most frequently asked questions about GC and GCMS (which may seem like simple questions but have anything but simple answers). We'll also answer new questions that we hope you will submit to us.By attending this webinar, you will learn:<ul><li>How different carrier gases impact results and what to consider when converting methods from one carrier gas to another.</li><li>What is column bleed, how it relates to thermal stability, how your carrier gas can impact it, and why it matters even when using selective detectors like mass specs.</li><li>What is the difference between gas cylinders and gas generators, and should you consider using gas saving measures when using a generator.</li></ul>What you need to know:Date: 7th November, 2024Start times:<ul><li>Broadcast #1: 7th November - 7:00 PST (Los Angeles) / 9:00 CST (Chicago) / 10:00 EST (New York) / 15:00 GMT (London) / 16:00 CET (Paris/Berlin)</li><li>Broadcast #2: 7th November - 11:00 PST (Los Angeles) / 13:00 CST (Chicago) / 14:00 EST (New York)</li><li>Broadcast #3: 8th November - 8:30 IST (New Delhi) / 11:00 SGT (Singapore) / 11:00 CST (Shanghai) / 12:00 JST (Tokyo) / 14:00 AEDT (Sydney) / 16:00 NZDT (Auckland)</li></ul>Duration: Approximately 60 minutes<blockquote>Presenter: Vanessa Abercrombie (MFS, GC Applications Chemist, Agilent Technologies)Vanessa Abercrombie is a GC applications chemist at Agilent Technologies in Folsom, California, USA. Vanessa has a broad background in GC and GC/MS, including experience as an instrument chemist at Bode Technology in Virginia working under contract to the FBI’s Laboratory Division. Prior to that, Vanessa worked for ETS Labs in St. Helena, California, as an analytical chemist, where she researched and developed quantitative separations by GC/MS and UHPLC for beer, wine, and spirits. She holds a Masters of Forensic Science from The George Washington University and a Bachelor of Arts in Chemistry from Sonoma State University.Presenter: Ed Connor (Product Manager, PEAK Scientific Instruments)Ed joined PEAK in 2013 as a GC product specialist and then moved to product management. He’s been working on many collaborative projects with PEAK customers and major instrument manufacturers worldwide. The main focus of these collaborations has been looking at conversion from helium to hydrogen carrier gas for GC applications. Ed completed his Dr.Sc. at ETH Zurich in 2007 using GC-MS to look at herbivore-induced plant volatiles and their interaction with beneficial insects. He then joined the University of Zurich where his work focused primarily on floral volatile analysis using a variety of volatile collection methods, GC-MS, and GC-FID.Moderator: Diane Turner (Director &amp; Senior Consultant, Anthias Consulting Ltd)A Warwick University graduate, Diane completed her Master's in analytical chemistry and started her career in environmental chemistry, later gaining significant experience as an applications chemist. Diane’s area of research through her PhD studies at The Open University was disease diagnosis. She has developed methods and given support and training for companies in most industries around the world for more than 20 years. Diane holds voluntary roles with The Royal Society of Chemistry and other scientific organizations.</blockquote>

Separation Science: Ask the Agilent Experts Series – Part 6: The Gas Edition

Ask the Agilent Experts Series – Part 6: The Gas Edition

GC and GC/MS scientists discuss and answer more of your most frequently asked questions.

Join us on November 14, 10 AM (EST) for a virtual roundtable discussion featuring top experts from AbbVie, Almac, and the FDA, as they share their insights into the evolving landscape of nitrosamine testing in the pharmaceutical industry.In this exclusive event, our distinguished panel will address critical topics, including the most significant analytical challenges and how to navigate them, cutting edge technologies, as well as regulatory trends for nitrosamine testing in the pharmaceutical industry.Key discussion points include:<ul><li>Overcoming the major challenges in detecting nitrosamines</li><li>Current techniques and technologies&nbsp;</li><li>How to build a robust method for nitrosamine analysis</li><li>The impact of recent regulatory changes on the industry</li><li>Future trends in nitrosamine testing and regulatory landscapes</li></ul>Gain insights from leading voices in pharmaceutical analysis and stay ahead of the latest trends in nitrosamine testing.Sign up now to reserve your spot.<blockquote>Presenter: Kevin Parker (Senior Scientist I, Analytical R&amp;D, Small Molecule CMC Development, AbbVie)Presenter: Jessica Hoskins (Principal Research Scientist I, Small Molecule Analytical R&amp;D, Predictive Stability and Structure Elucidation, AbbVie)Presenter: Alan Thompson (Technical Leader, Analytical Chemistry, Almac)Presenter: Jingyue Yang (Senior Research Scientist, US FDA)</blockquote>

The Analytical Scientist: Nitrosamine Analysis in the Pharma Industry: Trends, Challenges, and Future Perspectives

Nitrosamine Analysis in the Pharma Industry: Trends, Challenges, and Future Perspectives

A virtual roundtable discussion featuring top experts from AbbVie, Almac, and the FDA.

GCMS webinars focusing on Academy/Principles - page 4