<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 6th April 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies, BaySpec, </strong>poster by <strong>MDCW / William &amp; Mary </strong>and<strong> </strong>brochure by<strong> Shimadzu!</strong></p><h3><strong>1. Agilent Technologies: High-Throughput BTEX Analysis in Nail Products by SPME and GC/TQ</strong></h3><p><strong>Minimal steps, maximum precision</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_btex_analysis_nail_products_spme_gctq_5994_9009en_agilent_24ef32dd13.pdf"><strong>Full PDF for download</strong></a></li></ul><p>BTEX compounds—benzene, toluene, ethylbenzene, and xylenes—are volatile aromatic hydrocarbons widely used as solvents in industrial and consumer products. Among these, toluene is the most prevalent in nail polish formulations, where it serves as a solvent to dissolve resins and pigments, ensuring smooth application, uniform color dispersion, and rapid drying. Historically, these properties made toluene a preferred ingredient in nail coatings, including traditional polishes, gel formulations, and nail art products. However, its inclusion presents challenges for regulatory compliance and product reformulation. In response to these challenges, the California Department of Toxic Substances Control (DTSC) has listed nail products containing toluene as Priority Products under the Safer Consumer Products Regulations.1 Manufacturers selling such products in California must submit a Priority Product Notification and conduct an Alternative Analysis if toluene concentrations exceed the 100-ppm threshold.&nbsp;</p><p>To support compliance and ensure accurate monitoring of BTEX levels in nail products, robust analytical methods are essential. Solid phase microextraction (SPME) coupled with gas chromatography/triple quadrupole mass spectrometry (GC/TQ) has emerged as a preferred approach for volatile organic compound analysis due to its solvent-free sample preparation, high sensitivity, and compatibility with complex cosmetic matrices. The 8890 GC with 7000 Series GC/TQ offers enhanced detection capabilities through dynamic multiple reaction monitoring (dMRM), enabling precise quantification of BTEX compounds at trace levels, below regulatory thresholds. This platform provides the analytical rigor required for method validation, including limits of detection, recovery, and precision, ensuring compliance with California's stringent performance criteria and supporting industry efforts toward improving consumer product&nbsp;quality.&nbsp;</p><h4><strong>Experimental</strong></h4><h5><strong>GC/TQ analysis&nbsp;</strong></h5><p>Analyses were performed on an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890+GC"><strong>8890 GC</strong></a> coupled to a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7000"><strong>7000 Series GC/TQ </strong></a>equipped with an EI extractor ion source (Figure 2). The instrument operating parameters are listed in Table 2. The system was operated in splitless mode with an inlet temperature of 200&nbsp;°C, a purge flow of 3 mL/min, and a purge flow to split vent of 50&nbsp;mL/min at 2&nbsp;minutes. Carrier gas was helium at a constant flow of 0.693&nbsp;mL/min with a total flow of 53.7 mL/min. The chromatographic separation was accomplished on an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=DB-624+Ultra+Inert+column"><strong>Agilent J&amp;W DB-624 Ultra Inert column</strong></a> (20&nbsp;m × 0.18&nbsp;mm, 1&nbsp;µm, part number 121-1324UI). The oven program started at 40&nbsp;°C (hold 2&nbsp;minutes), ramped at 35&nbsp;°C/min to 160&nbsp;°C, and held for 2.58&nbsp;minutes, giving a total run time of 8.0&nbsp;minutes. The transfer line was maintained at 230&nbsp;°C, with the ion source at 230&nbsp;°C and quadrupoles at 150&nbsp;°C.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>A rapid, high-throughput headspace‑SPME GC/TQ method was developed for quantifying BTEX in nail product matrices, using a 100-µm PDMS Agilent Smart SPME fiber on an Agilent 8890 GC with Agilent 7000 Series GC/TQ. The method provides solvent-free extraction, 8-minute chromatographic runs, and an ~11-minute total cycle time, enabling high-throughput analysis with robust selectivity in dMRM mode. Quality control results demonstrated mean recoveries of 100 to 107% with RSDs ≤ 8%, meeting method acceptance criteria for compliance-focused testing for toluene. Integration of Smart SPME automation and the intelligent features of the 8890 GC and 7000 Series GC/TQ allows a practical, defensible solution for routine laboratories monitoring BTEX in nail products. Calibration performance showed high linearity and low variance across the working ranges, with all compounds meeting initial calibration criteria via R² ≥ 0.995 or average RF RSD ≤ 20%. Combined with the short cycle time and automated fiber tracking, this workflow is ideally suited for routine compliance testing of BTEX in nail products using the 8890 GC and 7000&nbsp;Series GC/TQ.</p><h3><strong>2. BaySpec: Detection of residual pesticides on fruits and vegetables using Portability miniature mass s pectrometer</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Bay_Spec_App_Note_Portability_Pesticides_4a7311fb3e.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Pesticides are used in a variety of different ways during the production of food. Ranging from preventing crop damage by insects, rodents and molds during growth to prolonging storage of food after harvest. Because of the frequent usage, the residual pesticides are often found in many agricultural products and their monitoring and control is an important step in achieving and maintaining overall food safety in the modern society.&nbsp;</p><p>Mass spectrometry in connection with different separation techniques currently represents the main analytical approach for determination of residual pesticides in food. Traditionally, samples need to be collected and send to a laboratory for analysis using techniques such as GC-MS or HPLC-MS, which are costly and time-consuming. In addition, the conventional mass spectrometry usually requires laborious sample pretreatment, which does not allow for immediate in-situ sample determination. Presented here is an application of Thermal Desorption ElectroSpray Ionization (TD-ESI) for pesticide screening coupled to a portable mass spectrometer.&nbsp;</p><p>TD-ESI is a mass spectrometry technique from the family of ambient ionization methods that utilizes very simple probing of different surfaces with no or limited sample pretreatment while it is still noted for its selective and sensitive detection capabilities. In TD-ESI a solid surface or a liquid sample is touched by a simple metallic probe that absorbs the analyte. The probe is then inserted into a heated tube and the desorbed analyte is carried by gas flow into an orthogonally mounted electrospray. The electrospraty plume extracts the analyte and further ionization and ion introduction follows the conventional electrospray mechanism.&nbsp;</p><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2219"><strong>Bayspec’s Portability mass spectrometer</strong></a> is less than 10kg highly portable and battery operated linear ion trap mass spectrometer with atmospheric pressure inlet (API). When TD-ESI is combined with PortabilityTM then it is possible to perform fast in-field detection of analytes including residual pesticides, directly of the surfaces of fresh food products without any sample pre-treatment. Fast pesticide screening by Portability mass spectrometer can immediately disclose fake organic food products as well as to discover elevated levels of residual pesticides.&nbsp;</p><p>TD-ESI-MS was used to rapidly screen residual pesticides on the surfaces of different fruits and vegetables. Direct sampling probe was used to introduce analytes from surfaces of unprocessed samples. Due to short analysis times (1-5s a sample), the technique allows for fast screening for applications in food and environmental safety. MS (as well as MS/MS) analyses can be performed on surface-residual pesticides at ppm and sub-ppm levels. The miniaturized TD-ESI ion source compatible with Portability is available from BaySpec. This ion source mounts on the Portability front inlet and does not require any additional support, external power or gases. The simple intuitive software interface is operated by touch screen and makes the instrument extremely easy to control. The external TD-ESI source is fully integrated into the main software environment and the hyphenated system is thus very user-friendly, does not require excessive training and can be operated by persons with no previous mass spectrometry experiences.</p><h3><strong>3. MDCW / William &amp; Mary: Volatile Characterization of American Foulbrood Disease Using Comprehensive Two-Dimensional Gas Chromatography</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/P_15_Christensen_39521e3391.pdf"><strong>Full PDF for download</strong></a></li></ul><p>American foulbrood (AFB) is a deadly disease spread by Paenibacillus larvae bacterial spores, targeting the brood stage of Apis mellifera honey bees. Broods perish in a matter of days after exposure to the spores, forming infected colloidal scales in the hive that adult bees cannot remove. 1,2 The spores are extremely persistent and resistant to typical treatment methods, which standardized the immediate euthanasia of bees and destruction of the hive and associated equipment by burning. 3 In an effort to expedite identification of the spores, scent-detection dogs have been trained for use in apiaries. Furthermore, gammairradiation has been tested as a proposed treatment method as it would offer a nondestructive alternative to sterilization.</p><p>The goals of this study were to use comprehensive two-dimensional gas chromatography – time-of-flight mass spectrometry (GC×GC-TOFMS) to characterize the volatiles associated with AFB disease for understanding scent detection and to measure the effectiveness of gamma-irradiation in sterilizing these volatiles.</p><h4><strong>Methods</strong></h4><p>Samples included blanks, material from healthy comb, aged unsterilized diseased scales, fresh unsterilized diseased scales, and diseased scales sterilized with the proposed treatment method of gamma-irradiation. These samples were stored in headspace vials (Figure 3) in the freezer when not in use. No sample preparation was required before injection with solidphase microextraction using the LPAL-3 (CTC Analytics).</p><p>Analysis was performed using a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37"><strong>Pegasus BT4D</strong></a> (LECO Corporation) according to the parameters described below in Table 1. <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/41"><strong>ChromaTOF software</strong></a> (LECO Corporation) was used to analyze the chromatographic data. Preliminary identifications were assigned to peaks using a minimum signal to noise of 200 and a minimum stick count of 3.</p><h4><strong>Conclusions</strong></h4><p>GC×GC-TOFMS can be used to distinguish the volatile profiles of A. mellifera samples at different stages of infection with AFB disease. Future Directions for Research:&nbsp;</p><ul><li>Discrimination of volatiles specific to AFB from non-specific volatiles&nbsp;</li><li>Characterization of AFB-specific volatiles for scent-detection purposes&nbsp;</li><li>Measurement of gamma-irradiation sterilization success in removing AFB volatiles</li></ul><h3><strong>4. Shimadzu: Screening System for Phthalate Esters, Brominated Flame Retardants and Other Regulated Substances Py-Screener Ver.3</strong></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c146_e507_45f041b0d7.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Py-Screener"><strong>Py-Screener™ Ver. 3</strong></a> can screen for 7 types of phthalate esters and brominated flame retardants (PBBs, PBDEs), including substances regulated under the RoHS Directive. In addition, it can also test for PIP (3:1), which is regulated under the US TSCA (Toxic Substances Control Act), as well as UV-328, Dechlorane Plus (DP), and short-chain chlorinated paraffins (SCCPs) and medium-chain chlorinated paraffins (MCCPs), which are regulated under the Stockholm Convention (POPs Convention) on Persistent Organic Pollutants (POPs). These regulated compounds, thermally extracted from the sample by Pyrolysis-GC-MS (Py-GC-MS), are selectively detected and quantified. Py-Screener Ver. 3 consists of dedicated software for easy screening, special standard samples, and a sampling tool kit, making it simple to operate even for first-time users.</p><h5><strong>Shimadzu Corporation’s Solutions for Complying with International Hazardous Substance Regulations</strong></h5><p>When manufacturing and exporting products, it is necessary to comply with the chemical and hazardous substance regulations established by each country. Products contain many parts and use various materials and substances. Therefore, it is the manufacturer’s responsibility to manage the entire supply chain to ensure that harmful substances are not contained. Shimadzu Corporation provides analysis solutions that comply with these regulations.</p><h5><strong>Applicable Systems and Software</strong></h5><ul><li><strong>GC-MS: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-QP2020+NX"><strong>GCMS-QP™2020 NX</strong></a>, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-QP2020"><strong>GCMS-QP2020,</strong></a> <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-QP2010+Ultra"><strong>GCMS-QP2010 Ultra</strong></a></li><li><strong>Pyrolyzer:</strong> <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=42&amp;search=EGA%2FPY-3030D"><strong>EGA/PY-3030D</strong></a> multi-shot pyrolyzer</li><li><strong>Autosampler:</strong> AS-2020E, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=42&amp;search=AS-1020E"><strong>AS-1020E auto-shot sampler&nbsp;</strong></a></li><li><strong>GC-MS Workstation:</strong> <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMSsolution"><strong>GCMSsolution</strong></a>™ (Ver. 4.60SP2 or later) + <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=LabSolutions+Insight"><strong>LabSolutions Insight</strong></a>™ (Ver. 5.0 or later)</li><li><strong>Py Workstation:</strong> EGA-PY3030 program (Ver. 1.54 or later)</li></ul>

News from LabRulezGCMS Library - Week 15, 2026

Microplastics and Nanomaterials: Understanding Emerging Contaminants in Environmental Testing

<div><div><div><p><strong>Our immune system is incredibly powerful: among other things, it can recognize and destroy cancer cells. But tumors can be just as effective at avoiding detection – they build “invisibility shields” to protect themselves from attack.</strong></p></div></div><div><p>One breakthrough in cancer therapy has been immune checkpoint inhibitors (ICIs), drugs that reactivate immune T cells and help them fight tumors again. However, only about 20–50% of patients respond well to this treatment. Researchers are therefore seeking alternative therapeutic strategies. A small and well-known molecule called adenosine plays a key role in these efforts.</p><p>When tumor cells are stressed or dying, they release ATP, which is normally a signal that something is wrong in the tissue. But in the tumor microenvironment, ATP gets rapidly broken down by two enzymes, CD39 and CD73. Released adenosine acts like a chemical “calm-down” signal, binds to immune cells (T cells, NK cells, and others), and tells them to slow down, reducing their ability to kill cancer cells. Targeting CD73 therefore represents a promising strategy for developing new cancer treatments.</p></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg" alt="IOCB Prague: Development of potent inhibitors to boost the immune system's ability to fight cancer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Nove_latky_mohou_podporit_imunitni_system_v_boji_s_rakovinou_88c5e82cd5.jpeg 245w," sizes="100vw" width="661" height="363"></p><p>At IOCB Prague, interdisciplinary teams led by Jan Řezáč, Jan Konvalinka, and Michal Hocek used a newly developed high-throughput screening method to test over 5,000 compounds, identifying two ribonucleoside derivatives as promising CD73 inhibitors.</p><p>The scientists then improved the compounds’ activity by carefully modifying the ribonucleoside scaffold with bulky (het)aryl groups. Further optimization improved the pharmacokinetic properties of these compounds, yielding inhibitors with low clearance, long half-life, high solubility, and strong selectivity over related enzymes such as CD39.</p><p>In cellular experiments, the compounds reduced adenosine production in cancer cells, restored T cell activation, and showed no toxicity toward human fibroblasts. The most active compound showed a single-digit picomolar inhibition constant (Ki).</p><p>These findings establish a strong foundation for further in vivo efficacy and combination studies, which will explore the therapeutic potential of this novel inhibitor class.</p><blockquote><h4><strong>The Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707"><strong>Potent Competitive Inhibitors of Ecto-5′-nucleotidase (CD73) based on 6-(Het)aryl-7-deazapurine Ribonucleoside 5′-O-Bisphosphonates</strong></a></h4><p>Ugnė Šinkevičiu̅tė, Magdalena Šímová, Radek Staník, Lenka Poštová Slavětínská, Kristýna Blažková, Pavel Šácha, Martin Lepšík, Jan Řezáč, Jan Konvalinka, Tereza Ormsby, Michal Tichý, Michal Hocek</p><p><i><span><strong>ACS Pharmacol. Transl. Sci.</strong></span></i><strong> </strong><span><strong>2026, 9, 1, 191–213</strong></span></p><p><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acsptsci.5c00707">https://pubs.acs.org/doi/10.1021/acsptsci.5c00707</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>CD73 generates immunosuppressive adenosine in the tumor microenvironment and is a promising target for cancer immunotherapy. We have designed and systematically studied diverse 2-substituted 7-deazapurine ribonucleoside 5′-<i>O</i>-bisphosphonates bearing a variety of (het)aryl groups at position 6 and discovered their highly potent and selective CD73 inhibition activity. The most active compounds (with single-digit picomolar <i>K</i><sub>i</sub>) contained bicyclic (het)aryl groups at position 6 in combination with chlorine at position 2. Further optimization of pharmacokinetic properties identified inhibitors with low clearance, long half-life, high solubility, and excellent selectivity over CD39 and NTPDase3. They effectively suppressed adenosine formation in MDA-MB-231 cells, rescued CD8<sup>+</sup> T cell activation, and were nontoxic to human fibroblasts. Overall, their profile compares favorably with <strong>AB680</strong>, a CD73 inhibitor currently in phase I/II clinical trials.</p></div>

Development of potent inhibitors to boost the immune system's ability to fight cancer

Article

Application

Environment

Scientific article

Science and research

Poster

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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Agilent Technologies

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LECO

Thermo Fisher Scientific

Wasson-ECE Instrumentation

Waters Corporation

<p><strong>As sustainable practices become more popular, reusing resources like wastewater and biosolids for agriculture is an enticing prospect. Microplastics detected in these are a concern, especially given their ability to adsorb contaminants. Their sources vary from a mix of local residential and industrial practices.</strong></p><p>Within a closed wastewater treatment system, we used LDIR to determine the quantity of microplastics at various points along the treatment process, as well as possible sources based on sewer samples.</p><blockquote><p><strong>Presenter:</strong> Ian Eggleston (Masters Student in Plant and Soil Sciences, Stockbridge School of Agriculture, UM, Amherst)</p><p>Ian is a Masters Student in the Plant and Soil Sciences program at Stockbridge School of Agriculture. His research focus is on microplastics in aquatic environments and their implications with agricultural practices. From experience testing PFAS and organic contaminants at an environmental lab, he applies similar methodology to microplastic analysis.</p></blockquote>

Agilent Technologies: Microplastics in Wastewater: A Population Based Approach to Identifying Potential Sources

Microplastics in Wastewater: A Population Based Approach to Identifying Potential Sources

Within a closed wastewater treatment system, we used LDIR to determine the quantity of microplastics at various points along the treatment process.

Microplastics in Wastewater: Identifying Potential Sources

<p><strong>This webinar will explore how the new Agilent 8850 gas chromatograph, now compatible with single and triple quadrupole mass spectrometry, can save users bench space, utility costs, and analysis time without compromising on performance. Viewers will see these features demonstrated through multiple applications, including gasoline aromatic composition by ASTM D5769, Total Petroleum Hydrocarbons (TPH), distilled spirits analysis, and more.</strong></p><blockquote><p><strong>Presenter: </strong>James Cain, PhD (Product Manager, Agilent Technologies, Inc.)</p><p>As Product Manager in the Gas Phase Separations Division of Agilent, James helps guide the development of new technology and insights for the gas chromatography market. He is focused on understanding the needs of GC users globally, tracking changes in the market and regulatory landscape, and seeking new opportunities to apply Agilent innovation to emerging applications.</p><p>James earned his BS in Chemistry from the University of Pittsburgh and PhD in Organic Chemistry from the University of Arizona. After serving in various research and commercial roles with other organizations, including as an Agilent customer, he has been a product manager with Agilent Technologies for the last four years.</p></blockquote>

Agilent Technologies: Becoming a Better Chromatographer - Educational Webinar Series

Small Size, Big Impact – High-Performance Benchtop GC and GC/MS with the Agilent 8850 GC

Learn how the Agilent 8850 GC with SQ/QQQ MS boosts efficiency and performance in TPH, ASTM D5769, spirits analysis, and more.

GC and GC/MS with Agilent 8850 GC

<div><div><div><div><div><div><article><div><div><div><div><div><div><article><div><div><div><div><div><div><article><div><div><div><div><div><div><p>Device for diluting standards with diluent gas to create multi-point calibrations from single cylinders.</p></div></div></div></div></div></div></article></div></div></div></div></div></div></article></div></div></div></div></div></div></article></div></div></div></div></div></div><blockquote><p><strong>Presenter:</strong> John Wasson</p><p>John Wasson has over 40 years of experience in Gas Chromatography and Chemical Instrumentation. He is President of Wasson-ECE Instrumentation, Inc.</p></blockquote>

Wasson-ECE Instrumentation: Free Webinar Series

Dynamic Blender

Device for diluting standards with diluent gas to create multi-point calibrations from single cylinders.

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Analytical determination of pesticides in chili peppers is highly challenging due to the complex matrix, which is rich in capsaicinoids and other lipophilic compounds that can significantly interfere with chromatographic analysis. Conventional chromatographic setups for routine pesticide analysis based on gas chromatography coupled to tandem mass spectrometry (GC-MS/MS) resulted in co-elution problems for several analytes with dominant matrix components.</strong></p><p>In this study, a method for the determination of a broad spectrum of pesticide residues in fresh and dried chili peppers was developed, optimized, and validated using QuEChERS extraction followed by comprehensive two-dimensional gas chromatography coupled to mass spectrometry (GCxGC-MS, Pegasus BTX).</p><p>The method was validated in accordance with the requirements of SANTE/11312/2021 (V2). For the majority of target pesticides, recoveries ranged between 70 and 120 %, with relative standard deviations below 20 %. Limits of quantification reached low µg/kg levels despite the complexity of the matrix.</p><p>Analysis of real samples confirmed the presence of multiple pesticide residues in all analyzed samples, with dried chili exhibiting a higher frequency and concentration of residues compared to fresh chili.</p><p>These findings confirm the high level of pesticide contamination in chili peppers and demonstrate that GCxGC-MS is a powerful and reliable tool for pesticide residue analysis even in such complex matrices.</p><blockquote><p><strong>Presenter: </strong>Michal Stupák, PhD (Assistant Professor, Department of Food Analysis and Nutrition | University of Chemistry and Technology Prague, Czechia)</p></blockquote></div></div></div>

LECO: Advanced GCxGC-MS Strategy for Pesticide Analysis in a Highly Complex Chili Pepper Matrix

Advanced GCxGC-MS Strategy for Pesticide Analysis in a Highly Complex Chili Pepper Matrix

GCxGC-MS (Pegasus BTX) combined with QuEChERS provides robust, SANTE-compliant pesticide residue analysis in complex chili pepper matrices.

GCxGC-MS for Pesticide Analysis in Chili Pepper Matrix

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Make faster, more confident decisions while improving consistency and control in therapeutic protein manufacturing.</strong></p><p>This webinar explores how real-time, in-line process monitoring delivers actionable, non-destructive insight across downstream operations. Learn how enhanced visibility into critical process parameters can reduce reliance on offline testing, strengthen process understanding and support continuous control strategies in downstream operations.</p><p>Join our industry expert to see how data-driven monitoring approaches help streamline workflows, minimize variability and address key challenges in modern biomanufacturing.</p><h4><strong>Attend this webinar to:</strong></h4><ul><li>Understand how Process Raman supports automation in biomanufacturing</li><li>Explore practical applications such as protein quantification during clarified harvest and excipient monitoring during ultrafiltration/diafiltration, integrating process control</li><li>Learn how to leverage data-rich insights to optimize workflows, enhance process understanding and address modern biomanufacturing challenges</li></ul><blockquote><p><strong>Presenter: </strong>Michelle Nolasco (Systems Design Engineer, Thermo Fisher Scientific)</p><p>Michelle Nolasco leads innovation initiatives and collaborations for bioproduction at Thermo Fisher Scientific. Michelle specializes in downstream processes and has experience in automation and advanced analytics.</p></blockquote></div></div></div>

Thermo Fisher Scientific: Real-Time In-Line Insight for Therapeutic Protein Production

Real-Time In-Line Insight for Therapeutic Protein Production

Learn how process Raman enables real-time monitoring, automation, and data-driven control to optimize downstream biomanufacturing workflows.

<div><h4><strong>Empower Tips</strong></h4><p><strong>Data integrity is the non-negotiable prerequisite for trust in pharmaceutical operations. Regulatory agencies like FDA and EMA have made it clear: data integrity failures are among the top reasons for warning letters, import alerts, and product recalls. When not properly understood and managed, risks can lead to severe consequences for your organization. Managing computerized system risks is critical to maintaining data integrity in regulated environments.</strong></p><p>In this session, our experts will address common challenges and practical strategies for managing risks. We will explore best practices for reducing vulnerabilities and for compliance with global regulatory expectations, and you will gain actionable insights to strengthen your data integrity program.</p><p>Protecting data integrity isn’t just about compliance - it’s about safeguarding patient safety, maintaining operational efficiency for supply chain resilience, and preserving your company’s reputation. With regulators tightening expectations and digital transformation accelerating, now is the time to understand and mitigate computerized system risks before they become liabilities.</p><h4><strong>In this webinar we will cover:</strong></h4><ul><li>Strategies to identify, assess, and mitigate risks</li><li>System configuration&nbsp;</li><li>Procedural controls</li><li>Best practices</li></ul><h4><strong>Who should attend?</strong></h4><ul><li>If you manage regulated data, this webinar is created for you!</li></ul><p><i>Don't miss it.</i></p><blockquote><p><strong>Presenter:</strong> Neil Lander (Senior Principal Product Manager, Waters Corporation)</p><p>Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Senior Principal Product Manager focusing on Informatics solutions.</p><p>He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives.</p><p><strong>Presenter:</strong> Tracy Hibbs (Principal Consulting Marketing Manager, Waters Corporation)</p><p>Tracy has been with Waters Corporation since 1999 and currently serves as Principal Consulting Marketing Manager, focusing on Informatics Solutions.</p><p>With extensive experience in roles such as Technical Trainer, Business Impact Consultant, and Education Manager, Tracy supports the Waters Empower software suite and drives the development of laboratory data management solutions that help organizations meet scientific and operational goals in regulated environments.</p><p>Prior to joining Waters, Tracy worked as a research scientist specializing in chromatography and data systems.</p></blockquote></div>

Waters Corporation: Ask Me Anything About Managing Computerized System Risks to Data Integrity

Ask Me Anything About Managing Computerized System Risks to Data Integrity

Learn how to manage computerized system risks in regulated labs. Discover practical strategies and best practices to protect data integrity.

Managing Computerized System Risks to Data Integrity

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p>As focus expands beyond water and soil, laboratories face an urgent need to monitor volatile PFAS in air and consumer products, driving demand for robust, flexible analytical workflows capable of addressing an increasingly broad range of volatile and semi-volatile fluorinated compounds in air.</p><p>In this session, industry experts from Markes present a comprehensive, end-to-end integrated sampling and analysis toolkit for these emerging applications in air and materials.</p><p>Case studies will include industrial applications such as the characterization of products of incomplete destruction (PIDs) associated with PFAS remediation and thermal treatment processes, aligned with US EPA OTM-50 methodologies, stack emissions and landfill gas. In addition, ambient air monitoring for environmental impact assessment will be discussed with relation to developing CEN practices.</p><p>Indoor air applications will also be covered in the context of human health concerns, with reference to ASTM D8560 and ASTM D8591, demonstrating approaches for assessing PFAS emissions in occupied spaces. Additional examples will explore PFAS emissions from consumer materials within the home and food contact materials.</p><p>Emerging approaches for total fluorine screening and non-targeted PFAS analysis will also be introduced, addressing the need to identify unknown or novel fluorinated compounds beyond conventional targeted lists.</p><h4><strong>What You’ll Learn</strong></h4><ul><li>Have the opportunity to view a demonstration of compliant workflows spanning sample collection, introduction, pre-concentration, separation, detection, and data interpretation</li><li>Learn how to assess PFAS off-gassing from consumer goods and food contact materials</li><li>Discover strategies for characterizing Products of Incomplete Destruction (PIDs), stack emissions, and landfill gas emissions</li><li>Explore approaches for total fluorine screening and identifying novel PFAS beyond the standard lists</li></ul><h4><strong>Who should attend?</strong></h4><ul><li>Environmental consultants, testing laboratories, and regulators seeking practical, end-to-end workflows to support evolving PFAS standards, guidance, and regulatory requirements.</li><li>Researchers and industry professionals working in PFAS remediation, product stewardship, materials development, or exposure assessment who need flexible tools for both targeted and non-targeted PFAS analysis.&nbsp;</li></ul><blockquote><p><strong>Presenter: </strong>Caroline Widdowson (Director of Scientific Affairs, Markes International)</p><p>Dr Caroline Widdowson is a specialist in the sampling and analysis of trace-level volatile and semi-volatile organic compounds in solids, liquids and gases. She holds a PhD in Organic Chemistry and an MBA. She is currently Director of Scientific Affairs at Markes, an advanced analytical instrument manufacturer.</p><p>Caroline works closely with international standards organizations, regulators, and scientific groups, supporting countries in the development of practical and reliable sampling and analytical methods. She is Chair of the UK national standards committee (BSI) for Indoor Air Quality and Convenor of ISO committee working groups that develop international standards for the measurement of VOCs in ambient, indoor, and in-vehicle air.</p><p><strong>Presenter:&nbsp;</strong>Aaron Davies (Channel Marketing Manager, Markes International)</p><p>Dr Aaron Davies holds a PhD in Chemistry from Cardiff and Monash Universities and brings extensive industrial experience as a Process and Product Development Chemist and GC–MS Product Specialist. In his current role as Channel Marketing Manager at Markes, Aaron focuses on his passion for thermal desorption, working closely with customers and channels to simplify sample preparation and optimize analytical methods.</p></blockquote></div></div></div>

SeparationScience: PFAS in Air: A Practical Toolkit for Real-world Applications

PFAS in Air: A Practical Toolkit for Real-world Applications

Discover practical solutions and emerging approaches for monitoring volatile and semi-volatile PFAS in air and materials.

PFAS in Air: Practical Toolkit for Real-world Applications

<div><h4><strong>Navigating Challenges and Opportunities for Environmental Testing Labs Under the Revised EU Water Framework Directive</strong></h4><p><strong>The European Commission’s proposed updates to the Water Framework, Groundwater, and Environmental Quality Standards Directives are bringing new responsibilities and opportunities for environmental testing labs. With expanded pollutant lists - including PFAS, pharmaceuticals, and pesticide metabolites—and stricter monitoring and reporting requirements, the landscape of water analysis is rapidly evolving.</strong></p><p>Join the 4th Waters Environmental Webinar Series to explore how your lab can navigate these challenges and turn regulatory change into opportunity.</p><p>Register for free and partner with us to shape the future of European water quality.</p><h5><strong>Why Attend</strong></h5><p>Stay ahead of new EU regulatory demands with insights from leading experts. Gain practical guidance, share experiences with peers, and prepare your lab for the next generation of water quality standards.</p><h5><strong>Highlights</strong></h5><ul><li>New pollutant categories and analytical challenges</li><li>Updates to monitoring protocols and reporting</li><li>Innovative methods to meet revised Environmental Quality Standards</li><li>Strategic guidance for compliance and adaptation</li></ul><p><strong>Lead the change in water analysis—stay ahead, stay compliant, and make a real impact.</strong></p><h4><strong>EPISODE 1: GC-MS/MS Under Atmospheric Pressure – What are the benefits for Dioxin and Pyrethroid analysis?</strong></h4><h5><strong>What You Will Learn</strong></h5><ul><li>How to reach highest sensitivity for Pyrethroids in aqueous samples</li><li>How to bring POP's analysis in environmental samples to an easy, flexible, and robust level</li><li>How to overcome the helium shortage - nitrogen as an alternative GC-carrier gas</li></ul><p><i><strong>Join and partner with us to shape the future of European water quality.</strong></i></p><blockquote><p><strong>Presenter:</strong> Matthias Ruff (Co-Fachbereichsleiter Umweltanalytik, Bau- und Verkehrsdirektion des Kantons Bern *BVD)</p><p>Dr. Matthias Ruff completed his dissertation at the University of Bern and ETH Zurich. He then pursued postdoctoral research at Eawag's Department of Environmental Chemistry. Since 2016, Dr. Ruff has been working for the Canton of Berne at the Laboratory for the Protection of Water and Soil. His expertise lies in Analytical Chemistry, with a focus on techniques such as LC-MSMS, LC-HRMS, GC-MSMS, and APGC-MSMS. The title of his presentation will be: easureing Pyrethroid- and other Insecticides in low pg/L-levels using AP-GC-MSMS – Experiences, Facts and Tasks</p><p><strong>Presenter: </strong>Daniel Dahlberg (Head of Development, SGS Environmental, Sweden)</p><p>Daniel works as head of development at SGS Environmental Sweden, previously SYNLAB Analytics &amp; Services and before that Alcontrol. In his current position he is working on new products for the SGS analytical portfolio, where analytical performance needs to be in line with regulations and client. In recent years they’ve been analysing around 5000 dioxin samples per year in diverse environmental matrices and food &amp; feed. Daniel previously held a position as technical specialist in organic analytical chemistry, with a focus on trace analysis with GC-MS (GC-MS, GC-MSMS and GC-HRMS), where he worked with method development and analysis of POPs. He started his career in dioxin analysis in 2010 on a magnetic sector instrument and in 2014 we started verification of performance on APGC and later on EI-GC-MSMS as well.</p><p><strong>Presenter: </strong>Cliff Svenman (Technical Specialist, SGS Analytics Sweden)</p><p>Cliff has spent 10 years as an analytical chemist working in an environmental contract lab with a focus on dioxins and PCBs. His main duties are method development, sample analysis and technical support. He started using APGC in 2017 and has developed several methods for the system since then.</p><p><strong>Presenter: </strong>Frank Dorman (Senior Principal Market Development Mgr<br>Waters)</p><p>Frank Dorman is currently Senior Business Development Manager at Waters, focusing on their global environmental business, and, concurrently, a resident scholar in the Chemistry Department at Dartmouth College in Hanover, NH. In his role at Waters, Dorman manages the research-focused environmental market, external collaborations, and interfaces with R&amp;D for new product development. Prior to this, he was an associate professor in the Department of Biochemistry and Molecular Biology (BMB) at Penn State University in University Park, PA. Dorman’s scientific interests are in gas and liquid chromatography and fundamental characterization, instrumentation and column development, and mass spectrometry and atomic spectroscopy applied to trace analysis in complex sample matrices.</p><p><strong>Presenter: </strong>Janitha De-Alwis (JD), Principal F&amp;E Market Development Manager, Waters Corporation</p><p>Janitha De-Alwis (known as JD) is an applications chemist in the European demo lab, based in Wilmslow, UK. His main role focuses on application development work for the food and environmental sector. JD takes great pride in speaking to, and advising, many food and environmental customers. His position requires him to be reactive and proactive to the changes in the food industry, such as changing regulations, topical issues and food safety risks.</p></blockquote></div>

GC-MS/MS Under Atmospheric Pressure – What are the benefits for Dioxin and Pyrethroid analysis?

Webinar on EU Water Framework Directive updates, new pollutant requirements, and advanced GC-MS/MS strategies for dioxins and pyrethroids analysis.

GC-MS/MS Under Atmospheric Pressure

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Join this practical, admin-focused session to get more out of the Thermo Scientific Chromeleon Administration Console. We’ll walk through proven tips, lesser-known features, and real-world best practices that help simplify user management, control access, improve performance, and reduce day-to-day admin headaches.</strong></p><ul><li><strong>Work smarter, not harder</strong> – Learn time-saving shortcuts and new features that streamline routine admin tasks.</li><li><strong>Avoid common pitfalls</strong> – Discover best practices that help maintain system stability, security, and compliance.</li><li><strong>Get expert insights</strong> – Pick up practical guidance you can apply immediately in your Chromeleon environment.</li></ul><p>This session is designed for <strong>anyone wanting to learn more about administration of Chromeleon CDS</strong>. &nbsp;Learn how to configure, maintain and support your Chromeleon software environment. You should attend if you want to learn how to <strong>manage users and permissions, control access and security, or discover best practices to reduce day-to-day admin effort</strong>. Get practical, immediately usable tips to keep your Chromeleon setup running smoothly, securely, and compliantly.</p><p><i>Cannot attend the broadcast on February 26? Please register anyway to automatically receive the link to the recording.</i></p><blockquote><p><strong>Presenter: </strong>Darren Barrington-Light (Senior Manager, Product Marketing, Thermo Fisher Scientific)</p><p>Darren Barrington-Light’s background includes over 25 years of experience in the field of analytical chemistry, chromatography hardware and computer software. Having worked in chromatography throughout his career, Darren has a unique understanding of the requirements of organizations that rely on chromatography data to manage their day to day operations. As capabilities have advanced, he has worked with clients across multiple industries to show them how software solutions can help them to improve their day to day operations and drive fast, informed decisions.</p></blockquote></div></div></div>

Thermo Fisher Scientific: Chromeleon Admin Console I: Expert Tips and Tricks

Chromeleon Admin Console I: Expert Tips and Tricks

Chromeleon Administration Console webinar: improve user management, security, performance, and compliance with practical admin best practices.

<p><strong>The Agilent Oil and Gas Insights Series 2026 presents three focused webinars showcasing advanced analytical solutions for natural gas and petrochemical applications. The series covers end‑to‑end natural gas characterization — from compositional analysis to sulphur detection and calorific value determination — followed by a deep dive into liquid chromatography workflows for petroleum products using the Agilent InfinityLab LC Series. The final session highlights fast, robust Micro‑GC technologies for mudlogging, hydrogen‑blended gas monitoring, and odorization control. Together, these sessions equip laboratories and operators with the tools to enhance accuracy, efficiency, and compliance across the energy value chain.</strong></p><h3><strong>Part 1: Natural Gas with Sulfur by Classical GC</strong></h3><p>In this seminar, you will learn about the solutions offered by Agilent for the natural gas production, from simple to more complex, including the detection of sulfur compounds in high or trace concentrations. This seminar is useful for understanding the characterization of the product as it comes from the well or once is ready for distribution to the end user. The calculation of the calorific value of the gas is key for this industry and is also covered in this talk.</p><blockquote><p><strong>Presenter: </strong>Mario Morales (Product Specialist IDO GC and GC/MS, Agilent Technologies)</p><p>Mario has over 24 years of experience as Field Service Engineer and a Pre-Sales GC/ GC-MS Specialist.</p><p><strong>Presenter:&nbsp;</strong>Laurent Pascaud (Product Specialist IDO GC and GC/MS,<br>Agilent Technologies)</p><p>After 10 years of experience within the French Anti-Doping Agency, Laurent Pascaud joined Agilent Technologies in 2007.</p><p>He now has over 15 years of analytical development expertise, first as an applications engineer and then as a GC and GC/MS product specialist in various chemical markets.</p></blockquote>

Agilent Technologies: Agilent Oil and Gas Insights Series 2026

Natural Gas with Sulfur by Classical GC

In this seminar, you will learn about the solutions offered by Agilent for the natural gas production, from simple to more complex.

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