<p><strong>The international standard ISO/IEC 17025 [1] clause 7.7.2 with regards to ensuring the validity of results, requires a laboratory to participate in proficiency testing (PT) and/or to participate in interlaboratory comparisons (ILCs) other than PT. However, no guidance as to what these other ILCs might be, or indeed how they might compare in relation to PT, is provided. This leaflet aims to outline other ILCs available, pointing out some of the limitations as compared to PT.&nbsp;</strong></p><p>There are three major types of ILCs in which a group of laboratories analyses identical portions from a homogeneous, stable test sample, with each type being characterized by its intended purpose [2,3]:</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_2_d9263807fb.jpg 245w," sizes="100vw" width="1507" height="607"></p><p>A key point is that PT is an ILC that is designed to specifically evaluate the performance of participants, providing them with an infrastructure to monitor and assess the validity of their results. This is not the key purpose of the two other ILCs, and thus depending on their intended purpose they have a number of limitations that laboratories need to be aware of when using them rather than PT. Only proficiency testing should have been conducted in full compliance to the competency standard ISO/IEC 17043 [4].&nbsp;</p><h4><strong>Evaluation of measurement procedure performance&nbsp;</strong></h4><p>These ILCs, are designed to assess how a particular measurement procedure performs and whether it is fit for its intended purpose. These ILCs are often referred to as a ‘method performance study’ or a ‘collaborative study’ [2]. Some limitations of using such ILCs for monitoring laboratory performance as an alternative to PT are:&nbsp;</p><ul><li>All participants use the same measurement procedure i.e. the measurement procedure that is being validated. Unless the measurement procedure is being routinely used by the participating laboratory such an ILC will not assess the routine performance of the laboratory using their own routine measurement procedure. Nor does it enable them to compare their performance with other laboratories using alternative measurement procedures.&nbsp;</li><li>The measurement procedure is likely to be new, so participants may not have established stable procedures and quality control, so performance may not reflect routine use.&nbsp;</li><li>The report from such an ILC would not provide information on the performance of the participant, if the statistical model used makes the assumption that all laboratories perform with equal variability.</li><li>The design of the study may require the participants to assess multiple samples and/or to undertake multiple replicate analysis on the test materials. This may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li><li>The conclusion of the ILC might be that the measurement procedure being assessed is not valid.&nbsp;</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg" alt="Eurachem: Interlaboratory comparisons other than proficiency testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_Interlaboratory_comparisons_other_than_proficiency_testing_3_a53ecd2f5d.jpg 157w," sizes="100vw" width="570" height="566"></p><h4><strong>Characterisation of candidate reference materials&nbsp;</strong></h4><p>These are ILCs that assign a property value to a candidate reference material, usually with a stated measurement uncertainty. These are often referred to as a ‘material certification study’ [2]. Limitations of using such ILCs as an alternative to PT are:&nbsp;</p><ul><li>The analysis of the candidate reference material is likely to require additional care in exercising the routine measurement procedure, such as substantially more replication, and/or may require quite different reporting formats (e.g. all valid replicates instead of a mean result). Thus, such an ILC will not necessarily provide an evaluation of the performance of the laboratory based on the routine use of their measurement procedures.&nbsp;</li><li>The report from such an ILC may include the results from the participating laboratories but would not provide information on the performance of each laboratory.&nbsp;</li><li>Participating laboratories may be required to assess multiple samples and/or to undertake multiple replicate analysis on the candidate reference materials. Thus this may not be representative of the routine measurements or tests undertaken by the laboratory.&nbsp;</li></ul><h4><strong>Other ILCs&nbsp;</strong></h4><p>Some other ILCs, whilst not being conducted in full compliance of the requirements of ISO/IEC 17043, may be designed to evaluate participant performance. These would include small ILCs as defined by EA‑2/21 [5] or split sample ILCs i.e. where a portion of a single sample is sent to two or three laboratories. Whilst these ILCs are specifically designed to evaluate participant performance, they may not provide a comprehensive comparison that a PT might provide. In such cases the laboratory needs to evaluate carefully the competence of the organization managing the ILC and the suitability of the service externally provided (ISO/IEC 17025 clause 6.6).</p>

Interlaboratory comparisons other than proficiency testing

RI Calibration in NIST26 Chromatogram and Applying to Calculating RI in Samples

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 29th June 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application note by <strong>Agilent Technologies, </strong>presentation by <strong>MDCW / William &amp; Mary </strong>and posters by <strong>Shimadzu</strong> and <strong>Thermo Fisher Scientific</strong> <strong>/ ASMS!</strong></p><h3><strong>1. Agilent Technologies: Residual Solvents Analysis Based on the 2025 USP &lt;467&gt; and Chinese Pharmacopoeia (ChP 0861)</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/br_8890b_gc_5994_9205en_agilent_fb5db29527.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p><strong>Using the </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8697"><strong>Agilent 8697 headspace sampler</strong></a><strong> and </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B"><strong>Agilent 8890B GC system</strong></a></p><p>Residual solvents are routinely introduced during pharmaceutical manufacturing as part of synthesis, purification, or formulation processes. Because these volatile organic compounds may pose toxicological risks, their levels must be carefully monitored to ensure patient safety and regulatory compliance. As a result, residual solvent analysis remains a critical component of quality control throughout the pharmaceutical development and manufacturing lifecycle.&nbsp;</p><p>USP &lt;467&gt; provides a harmonized framework for residual solvent analysis, defining solvent classifications, concentration limits, and analytical requirements.1 In September 2025, USP &lt;467&gt; was revised to reflect updated toxicological evaluations and regulatory expectations. The revised chapter expanded the class 2B solvent list and introduced performance requirements for newly added compounds, including tertiary butyl alcohol and cyclopentyl methyl ether (CPME). These updates increase the analytical scope of residual solvent testing and place greater emphasis on consistent system performance and suitability verification. In China, residual solvent control is governed by General Chapter 0861 of the Chinese Pharmacopoeia (ChP 0861)2 , which adopts a risk based classification system consistent with the International Council for Harmonisation (ICH) Q3C.3 Although the Chinese Pharmacopoeia uses different terminology for analytical procedures, its regulatory intent, solvent classification, and control principles are harmonized with USP &lt;467&gt;.&nbsp;</p><p>Gas chromatography with headspace sampling is widely used for residual solvent determination due to its robustness and suitability for volatile analytes. Alongside evolving regulatory requirements, modern GC systems have increasingly focused on intelligent operation to support method execution and compliance. The Agilent 8890B gas chromatograph incorporates GC Assist to help users perform a performance check of the GC system. When performance criteria are not met, the GC system provides alerts to notify the user. Upon user instruction, the GC can initiate a guided troubleshooting workflow, supporting step-by-step fault diagnosis through autonomous diagnostic functions, helping both experienced and less experienced analysts resolve issues efficiently during routine operation. In this application note, a headspace GC/FID method is presented for the determination of class 1, 2A, and the expanded class 2B residual solvents. This study demonstrates how updated regulatory requirements can be addressed using an intelligent GC platform that supports reliable system performance assessment, simplified troubleshooting, and consistent analytical performance.</p><h4><strong>Experimental</strong></h4><p>The experimental conditions described in this study follow the general chromatographic principles outlined in USP &lt;467&gt; procedures A and B. They are also consistent with the recommended headspace GC methods described in ChP 0861. In this work, the screening and confirmation concepts of procedures A and B were implemented simultaneously through a dual-column, dual-FID/GC configuration. Samples were introduced by an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8697"><strong>Agilent 8697 headspace sampler</strong></a> to an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B"><strong>8890B GC</strong></a> and equally split to an Agilent DB-Select 624 UI and a DB-WAX UI column for parallel detection, as shown in Figure 1. Comparable chromatographic performance was achieved with both helium and nitrogen carrier gases. Data were acquired using Agilent OpenLab CDS version 2.8, and noise was determined using a peak-to-peak (PtoP) approach for calculation of signal-to-noise ratios for target analytes.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>This application note demonstrates a harmonized headspace GC/FID workflow suitable for residual solvent analysis in compliance with both the 2025 revision of United States Pharmacopoeia (USP) &lt;467&gt; and the Chinese Pharmacopoeia (ChP 2025, General Chapter 0861). By implementing a dual‑column, dual-FID configuration on a single inlet, screening and confirmatory analyses can be performed simultaneously, significantly reducing total analysis time compared to traditional sequential approaches while maintaining orthogonal separation selectivity. The integrated Agilent 8697 headspace sampler and 8890B GC platform provides consistent chromatographic performance with both helium and nitrogen carrier gases, supporting flexible laboratory operation without compromising data quality. Beyond analytical performance, the intelligent capabilities of the 8890B GC enhance operational reliability and simplify daily use. Through continuous interaction with the user, the built‑in GC Assist function operates in a guided, wizard‑like manner, leading users step by step through the troubleshooting process for effective fault diagnosis. Together, these features enable a compliant, time-efficient, and user-friendly solution for residual solvent testing under the latest USP &lt;467&gt; and ChP&nbsp;0861 requirements.</p><h3><strong>2. MDCW / William &amp; Mary: Developing a Combined Approach to Green Gunshot Residue Analysis in the Forensic Laboratory</strong></h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_24_Saunders_f2c5bcdb20.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>Developing a Combined Approach to Green Gunshot Residue Analysis in the Forensic Laboratory presents a multidisciplinary strategy for improving the forensic analysis of <strong>"green" gunshot residue (GSR)</strong>, which originates from lead-free ammunition. Traditional GSR analysis relies heavily on the detection of lead, barium, and antimony particles using scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS). However, environmentally friendly ammunition replaces these heavy metals with more common elements, making conventional forensic protocols less effective. The authors therefore propose combining inorganic GSR (IGSR) characterization by SEM-EDS with organic GSR (OGSR) analysis using comprehensive two-dimensional gas chromatography coupled with mass spectrometry (GC×GC-MS).</p><p>The presentation first describes the development of a new SEM-EDS characterization strategy tailored to green GSR particles. Instead of relying solely on the elemental composition defined by existing OSAC guidelines, the approach incorporates both particle morphology and elemental complexity. In parallel, the researchers optimized an extraction procedure for organic residues and developed a dedicated GC×GC-MS method. Method optimization focused on key chromatographic parameters such as inlet temperature, modulation period, carrier gas selection, and oven temperature program. Compared with previously published methods, the optimized workflow provided higher peak capacity, improved analyte resolution, and enhanced detection of characteristic OGSR compounds.</p><p>To verify the analytical performance, the optimized GC×GC-MS method was evaluated using several reference standards, including phthalates, nitroaromatic explosives, nitroglycerin, and a multi-component gun surveillance standard. The resulting two-dimensional chromatograms demonstrated excellent separation and clear identification of compounds relevant to firearm discharge residues, confirming that the method can reliably detect a broad range of organic GSR markers. The combination of enhanced chromatographic separation with mass spectrometric detection offers substantially greater resolving power than conventional one-dimensional GC-MS, making it particularly valuable for complex forensic samples.</p><p>The authors conclude that integrating SEM-EDS with GC×GC-MS provides a more comprehensive approach to modern GSR analysis, particularly for lead-free ammunition. The study successfully established a characterization strategy for inorganic green GSR, optimized extraction and chromatographic conditions for organic GSR, and verified the visibility and identification of target analytes using certified standards. Future work will focus on further method validation, incorporating retention indices and sorbent-based extraction techniques, and strengthening the scientific robustness of the approach to support forensic evidence under <strong>Rule 702</strong>, thereby improving the reliability and courtroom acceptance of green GSR analyses.</p><h3><strong>3. Shimadzu / ASMS: Impact of Soil Matrix on Microplastics Analysis by Py-GC/MS</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/TP_222_Impact_of_Soil_Matrix_on_Microplastics_Analysis_by_Py_GCMS_63fdb8ef7d.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The matrix is not just background—it actively participates in pyrolysis chemistry. Lignin-rich soils can co-pyrolyze, producing compounds that overlap with common PS or PVC markers, complicating interpretation. Matrix variability is substantial, with clear chemical and physical differences between forest soils, agricultural land, river sediments, and landfill cover materials. Soil particles act as sinks and sorbents, interacting with microplastics and altering degradation pathways. Sample preparation can introduce bias, and in some cases does more harm than good.&nbsp;</p><p>In this poster, we present a method to improve quantitative accuracy in Py-GCMS microplastics analysis by assessing the matrix effect, while also addressing key challenges in the qualitative identification</p><h4><strong>Experimental Methods&nbsp;</strong></h4><ul><li>Three soil samples were collected from different locations (Figure 1) and homogenized using a mortar/pestle.&nbsp;</li><li>From each sample, 200g were dried in a vial for 3 hours at 40C and 2mg was weighed into a PY cup.&nbsp;</li><li>Targeted microplastics include PE, PP, PS, ABS, PMMA, PC, PVC, N6, and N66. The percentage distribution of polymers in the MPs-CaCO3 standard, as well as the mass of each analyte in a 4 mg standard within a CaCO3 diluent, is shown in Figure 1.&nbsp;</li><li>These were analyzed using a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Py-GC%2FMS"><strong>PY-GCMS instrument</strong></a>, shown in Figure 2.&nbsp;</li><li>A 5-point calibration curve was prepared, in triplicate, by weighing 0.2mg, 0.4mg, 0.8mg, 2.0mg, and 4.0mg from Frontier’s Low calibration standard mix of microplastics.&nbsp;</li><li>A matrix-matched calibration curve was generated by spiking sample B with the same concentration as the calibration levels.&nbsp;</li><li>Samples were analyzed, and analytes in the sample were quantified in µg, calculated using the calibration curve of known standard concentration.&nbsp;</li><li>Recovery studies were performed in blank samples to evaluate matrix effect for the targeted analytes. For this, a 2mg sample was weighed in triplicate, and 2mg of the standard mix was combined with 2mg of CaCO3 diluent.</li></ul><h4><strong>Conclusions</strong></h4><p>Future work will focus on improving microplastic identification by using multiple markers to reduce false positives, while advancing polymer identification tools and spectral libraries to better handle high-background matrix interferences.</p><p>Sample preparation is an important factor, and it needs to be considered and studied for different sample types, including environmental and clinical samples</p><h3><strong>4. Thermo Fisher Scientific / ASMS: Untargeted analysis of volatile PFAS in indoor air by thermal desorption GC high resolution </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/472"><strong>Orbitrap Mass Spectrometer</strong></a></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_004717_lsms_volatile_pfas_air_exploris_gc_efs_po004717_asms2026_na_en_69541bd1e3.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Per- and polyfluoroalkyl substances (PFAS) are persistent “forever chemicals” widely used in consumer products and commonly detected in indoor air. Volatile PFAS can originate from treated materials and degrade into harmful compounds linked to adverse health effects. Thermal desorption (TD) enables efficient air monitoring by preconcentrating volatile compounds for direct GC-MS analysis. Coupling TD with high-resolution Orbitrap GC-MS and advanced data processing allows comprehensive, untargeted screening of PFAS, supporting improved indoor air quality assessment.</p><h4><strong>Materials and methods</strong></h4><h5><strong>Sample preparation&nbsp;</strong></h5><ul><li>PFAS standards prepared in methanol and spiked onto sorbent tubes</li><li>Indoor air sampled (35 L) from carpeted, non-carpeted, and cleaning storage areas&nbsp;</li><li>Air collected using sorbent tubes with pumped sampling (TD-compatible). Test method(s)&nbsp;</li><li>Samples analyzed using thermal desorption (TD)–GC-MS (<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/472"><strong>Orbitrap Exploris GC</strong></a>)&nbsp;</li><li>TD preconcentration followed by GC separation and HRAM full-scan acquisition (EI/CI)&nbsp;</li><li>Method enabled untargeted screening of volatile compounds.&nbsp;</li></ul><h5><strong>Data analysis&nbsp;</strong></h5><ul><li>Data processed using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/76"><strong>Thermo Scientific Chromeleon CDS</strong></a>, FreeStyle, and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1759"><strong>Compound Discoverer Software&nbsp;</strong></a></li><li>Workflow included peak detection, deconvolution, and library matching.</li></ul><h4><strong>Conclusions&nbsp;</strong></h4><ul><li>TD-GC Orbitrap MS enables sensitive, untargeted detection of volatile PFAS in indoor air with minimal sample preparation&nbsp;</li><li>HRAM data combined with advanced software workflows provides confident identification and efficient data filtering&nbsp;</li><li>Higher PFAS levels observed in carpeted and cleaning areas, highlighting indoor sources and exposure risk</li></ul></div></div></div></div></div></div></section></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 27, 2026

Article

Application

Academy

Video

Software

Poster

Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

Eurachem

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

James Little/Mass Spec Interpretation Services

EST Analytical AS120 Autosampler

The AS120 GC Autosampler boosts productivity with dual-injector support, 120/200 vial capacity, programmable injections, and seamless GC/GC-MS integration.

<p><strong>The AS120 Autosampler is a cost-effective, fully electric XYZ sampler for GC and GC/MS applications. Driven by stepper motor technology, it combines modern engineering with user-friendly operation, meeting both routine and advanced analytical needs. With high-capacity sample trays, flexible injection modes, and reliable performance, the AS120 ensures laboratories can boost productivity while maintaining precise, consistent results.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/EST_Analytical_AS_120_Autosampler_7cc5a79884.jpg" alt="EST Analytical: AS120 Autosampler" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_EST_Analytical_AS_120_Autosampler_7cc5a79884.jpg 203w," sizes="100vw" width="1056" height="812"></p><h4><strong>Key Features</strong></h4><h5><strong>Maximum Productivity</strong></h5><ul><li>Dual-injector capability for maximum GC throughput</li><li>Automated injector alignment—no manual adjustments required</li><li>Variable injection rate tailored to injector type and analytical method</li><li>Choice of 120- or 200-position sample trays, easily removable for quick loading</li></ul><h5><strong>Durable, Flexible Engineering</strong></h5><ul><li>Robust XYZ syringe mechanism accesses vials, solvents, and standards with precision</li><li>Adjustable parameters: injection volume, speed, dwell times, and solvent flush options</li><li>Supports multiple methods per sequence and dual-column operation</li><li>Fully programmable via intuitive keypad interface</li></ul><h5><strong>Hassle-Free Operation</strong></h5><ul><li>Compatible with screw-cap and crimp-top septum vials</li><li>Simple GC integration with standard remote I/O signals and RS-232 communication</li><li>Quick mounting with keypad-based syringe/injector alignment</li><li>Priority manual sample feature enables urgent “RUSH” sample handling</li></ul><h4><strong>Technical Specifications</strong></h4><ul><li><strong>Drive</strong>: All-electric, stepper motor XYZ system</li><li><strong>Capacity</strong>: 120 or 200 vial tray options</li><li><strong>Compatibility</strong>: GC and GC/MS systems with standard I/O and RS-232 interface</li><li><strong>Injection Modes</strong>: Variable rate, programmable volume, dual-injector support</li><li><strong>Control</strong>: Keypad-driven menu with multiple method programming</li><li><strong>Sample Handling</strong>: Screw-cap or crimp-top septum vials</li></ul>

EST Analytical FLEX 2 Robotic Sampling Platform

The FLEX 2 autosampler streamlines GC/GC-MS workflows with liquid, headspace, and SPME capability, MTX tool change, and Prep Ahead for faster, more reliable VOC analysis.

<p><strong>The FLEX 2 is a versatile GC autosampler designed to handle both sample preparation and sample introduction for GC and GC/MS analysis. Supporting liquid injection, headspace, and SPME, it delivers exceptional accuracy and reproducibility. Its Prep Ahead function improves efficiency by allowing sample preparation during ongoing GC runs, maximizing system utilization and throughput.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/EST_Analytical_FLEX_2_Robotic_Sampling_Platform_3_853e02f151.jpg" alt="EST Analytical: FLEX 2 Robotic Sampling Platform" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_EST_Analytical_FLEX_2_Robotic_Sampling_Platform_3_853e02f151.jpg 168w," sizes="100vw" width="628" height="584"></p><h4><strong>Key Features</strong></h4><h5><strong>Flexible Sample Preparation with Multi Tool Change (MTX)</strong></h5><ul><li>Automated <strong>Multi Tool Change (MTX)</strong> enables seamless switching between tools</li><li>Enhances laboratory productivity, accuracy, and safety by reducing manual prep errors</li><li>Supports dilution, reagent addition, and internal standard spiking with precision</li><li>Can operate as a benchtop preparation station for derivatization and extraction steps</li></ul><h5><strong>Liquid Injection Capabilities</strong></h5><ul><li>Injection range: <strong>0.5–10 μL</strong> (standard syringe) or <strong>50–500 μL</strong> (optional large-volume syringe)</li><li>Supports both standard and large-volume injections (up to 500 μL)</li><li>Programmable injection speed control, from ultra-fast to very slow</li><li>Optional cooled trays available for temperature-sensitive samples</li></ul><h5><strong>Headspace Sampling</strong></h5><ul><li>Injection range: <strong>100–2500 μL</strong> (2.5 mL syringe), <strong>100–1000 μL</strong> (1.0 mL syringe), or <strong>500–5000 μL</strong> (5.0 mL syringe)</li><li>Offers both <strong>orbital</strong> and <strong>oscillating</strong> agitation to improve sample consistency</li><li>Six heated vial positions for <strong>2, 10, or 20 mL vials</strong></li><li>Temperature range: <strong>ambient to 200 °C</strong></li><li>Shaking: orbital (120–750 rpm) or oscillation (190 Hz)</li></ul><h5><strong>Automated SPME</strong></h5><ul><li>Compatible with both traditional and direct immersion SPME methods</li><li>Heated conditioning station:<ul><li>Fiber: <strong>ambient to 350 °C</strong></li><li>Needle: <strong>ambient to 150 °C</strong></li><li>Sweep gas port for conditioning</li></ul></li><li>Heated mixing station: <strong>ambient to 150 °C</strong>, mixing speeds <strong>380–725 rpm</strong></li></ul><h5><strong>Efficiency &amp; Throughput</strong></h5><ul><li><strong>Prep Ahead function</strong> allows ongoing sample prep during GC runs</li><li>Fully automates switching between liquid injection, headspace, and SPME with MTX</li><li>Reduces manual workload and preparation errors while improving reproducibility</li></ul><h4><strong>Technical Specifications</strong></h4><ul><li><strong>Compatible Systems</strong>: GC and GC/MS platforms</li><li><strong>Injection Modes</strong>: Liquid (0.5–500 μL), Headspace (100–5000 μL), SPME (traditional &amp; direct immersion)</li><li><strong>Temperature Ranges</strong>: Headspace up to 200 °C, SPME fiber up to 350 °C, SPME needle up to 150 °C</li><li><strong>Agitation</strong>: Orbital (120–750 rpm) and oscillating (190 Hz)</li><li><strong>Capacity</strong>: Six heated vial positions for 2, 10, or 20 mL vials</li><li><strong>Automation</strong>: Multi Tool Change (MTX), Prep Ahead function</li></ul>

EST Analytical LGX-50 for Methane in Water

The EST LGX-50 automates RSK-175 dissolved gas testing in water, boosting throughput, ensuring ASTM/EPA compliance, and reducing manual sample preparation errors.

<p><strong>The LGX-50 automates the preparation of water samples for headspace analysis of dissolved gases such as methane, ethane, and ethene. Traditionally, RSK-175 testing has been labor-intensive and time-consuming, requiring manual vial preparation. The LGX-50 eliminates this step, streamlining workflows and ensuring compliance with EPA Method 5035 and ASTM D8028. By automating dissolved gas extraction, laboratories can boost throughput, reduce errors, and deliver more consistent results for shale gas and environmental testing.</strong></p><h4><strong>Key Features</strong></h4><h5><strong>Maximized Productivity</strong></h5><ul><li>Fully automates <strong>RSK-175 sample processing</strong></li><li>ASTM D8028 compliant for dissolved gas testing</li><li>Holds up to <strong>50 samples</strong> for high-throughput operation</li><li>Optical sensors prevent vial misplacement and syringe/elevator errors</li><li>Robust XYZ design ensures reliability and consistent performance</li></ul><h5><strong>Simplified Operation</strong></h5><ul><li>Intuitive, user-friendly software designed for quick setup and operation</li><li>Remote access functionality allows labs to monitor sample progress via the server</li><li>Reduces manual preparation steps, increasing accuracy and reproducibility</li></ul><h4><strong>Technical Specifications</strong></h4><ul><li><strong>Compliance</strong>: EPA Method 5035, ASTM D8028</li><li><strong>Capacity</strong>: Up to 50 samples per batch</li><li><strong>Target Compounds</strong>: Methane, ethane, ethene, and other dissolved gases in water</li><li><strong>Automation</strong>: XYZ robotic design with optical sensors for error prevention</li><li><strong>Software</strong>: Intuitive, remote-access capable interface</li></ul>

Watrex Helium Saver – intelligent helium savings for GC/MS

Helium Saver™ by Watrex Praha cuts helium use in GC/MS. It auto-switches to nitrogen when idle, prevents manual errors, and lowers costs without sacrificing analytical quality.

<p><strong>An automated device that significantly reduces helium consumption in gas chromatography. It switches between helium and nitrogen according to the set schedule, eliminates errors from manual switching, and lowers operating costs – without compromising measurement quality. Easy configuration via USB, universally compatible with any GC/MS system.&nbsp;</strong></p><p>Helium Saver™ by <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>Watrex Praha</strong></a> is an innovative device designed for gas chromatography (GC) and GC/MS systems, providing an efficient answer to the rising costs of helium. Helium is indispensable for GC/MS thanks to its inertness and separation properties, but it is scarce, expensive, and its price continues to increase.&nbsp;</p><h4><strong>How does Helium Saver™ work?&nbsp;</strong></h4><p>The device automatically switches between helium and nitrogen according to a user-defined schedule:&nbsp;</p><ul><li>during measurements, helium is used,&nbsp;</li><li>outside of working hours (e.g., overnight), the system runs on nitrogen,&nbsp;</li><li>before the start of the working day, the chromatograph is automatically flushed with helium, ensuring it is ready for analysis.&nbsp;</li></ul><p>This process eliminates the need for manual switching, reduces human error, and significantly lowers helium consumption.&nbsp;</p><h4><strong>Key Benefits&nbsp;</strong></h4><ul><li><strong>Helium and cost savings&nbsp;</strong>– consumption of helium reduced by tens of percent.</li><li><strong>No compromise in measurement quality&nbsp;</strong>– analyses are always performed under optimal conditions.&nbsp;</li><li><strong>Easy USB configuration&nbsp;</strong>– the device connects as a flash drive, settings can be edited in any text editor, no special software required.&nbsp;</li><li><strong>Universal compatibility&nbsp;</strong>– easily integrates with any GC/MS system.&nbsp;</li><li><strong>Automatic and manual modes&nbsp;</strong>– flexible operation depending on laboratory needs.&nbsp;</li><li><strong>Multi-instrument support&nbsp;</strong>– can be configured for multiple gas chromatographs simultaneously.&nbsp;</li></ul><h4><strong>Why choose Helium Saver™?&nbsp;</strong></h4><p>Helium Saver™ is the ideal choice for laboratories aiming to cut operating costs, increase efficiency, and contribute to more sustainable use of helium – a limited natural resource. The device combines user-friendly operation with intelligent automation, offering a modern solution for everyday laboratory practice.</p>

BaySpec Continuity Portable Mass Spectrometer

Continuity™ is a highly sensitive portable mass spectrometer with built-in MS/MS, broad mass range, and ambient ionization, delivering real-time, lab-quality analysis directly in the field without sample preparation.

<h3><strong>Higher sensitivity portable mass spectrometer</strong></h3><p><strong>Continuity™ - the most sensitive portable mass spectrometer designed to provide quality and reliable mass spectrometer analysis outside of the laboratory. Continuity™ was created to provide even higher sensitivity, greater specificity with built-in MS/MS, and larger mass range coverage than its ground-breaking counterpart Portability™.&nbsp;</strong></p><p>Like its counterpart, Continuity™ requires no sample preparation and is compatible with almost any ambient ionization source including ESI, APCI, TD-ESI, TD-APCI, and DBDI. It allows for a broad range of applications from clinical to drug to chemical and biological threats analysis. The user-friendly interface, rapid deployment, and real-time results make Continuity™ a great solution for fast, dependable, and highly sensitive field analysis for any user in any location. This potable mass spectrometer is the excellent solution for various challenging applications, including vapors/liquids/solids, CWAs/TICs, biological/biomedical, forensic, agriculture, food safety, security, and explosives.</p><h4><strong>Key Features</strong></h4><ul><li>Portable and High Sensitivity</li><li>Vapors, Liquids, Solids</li><li>Ambient Ionization</li><li>MS/MS Analysis</li><li>No Tanks or External Pumps</li><li>No Sample Prep</li><li>Field Analysis Ready</li><li>Real-time Results</li></ul><h4><strong>Technical specification</strong></h4><ul><li><strong>Mass Range: </strong>m/z = 50 – 1200 amu&nbsp;&nbsp;</li><li><strong>Detection Limit: </strong>High parts-per-trillion/ picograms</li><li><strong>Mass Resolution: </strong>0.49 amu (FWHM)&nbsp;&nbsp;&nbsp;&nbsp;</li><li><strong>MS/MS Capability:</strong> Yes&nbsp;&nbsp;</li><li><strong>Dimension:</strong> 15 x 15 x 15.5 in&nbsp;&nbsp;&nbsp;</li><li><strong>Weight:</strong> 44 lbs. (20 kg)</li></ul>

BaySpec Portability Miniature Portable Mass Spectrometer

BaySpec Portability is an ultra-compact portable mass spectrometer delivering real-time, lab-quality MS/MS analysis in the field with no sample preparation and broad ambient ionization compatibility.

<h3><strong>Portable real-time mass spectroscopic analysis</strong></h3><p><strong>Portability™ - BaySpec’s miniature portable mass spectrometer. This ultra-compact portable mass spectrometer was designed to provide master quality and reliable mass spectroscopic analysis outside of the laboratory. Portability™ strips out the cost of and logistics chore for lab test outsourcing. Requiring no sample preparation and its compatibility with almost any ambient ionization source including ESI, APCI, TD-ESI, TD-APCI, and DBDI.&nbsp;</strong></p><p>This self-contained portable mass spectrometer offers a simple solution for a wide range of applications, such as vapors/liquids/solids, CWAs/TICs, biological/biomedical, forensic, agriculture, food safety, security, and explosives. The user-friendly interface, rapid deployment, and real-time results make Portability a great solution for fast and dependable field analysis for any user in any location.</p><h4><strong>Key Features</strong></h4><ul><li>Ultra-compact &amp; Potable</li><li>Vapors, Liquids, Solids</li><li>Atmospheric Ionization</li><li>MS/MS Capability</li><li>No Tanks or External Pumps</li><li>No Sample Prep</li><li>Field Analysis Ready</li><li>Real-time Results</li></ul><h4><strong>Technical specification</strong></h4><ul><li><strong>Mass Range: </strong>m/z = 50 – 600 amu&nbsp;&nbsp;</li><li><strong>Detection Limit: </strong>Low parts-per-billion/ nanograms</li><li><strong>Mass Resolution: </strong>0.49 amu (FWHM)&nbsp;&nbsp;&nbsp;&nbsp;</li><li><strong>MS/MS Capability:</strong> Yes&nbsp;&nbsp;</li><li><strong>Dimension:</strong> 14.5 x 13 x 9 in&nbsp;&nbsp;&nbsp;</li><li><strong>Weight:</strong> 22 lbs. (10 kg)</li></ul>

BaySpec Agility Portable Mass Spectrometer

Agility™ is BaySpec’s most compact, lightweight mass spectrometer, delivering Portability™-level performance with the lowest SWaP in the lineup.

<p><strong>The epitome of streamlined mass spectrometry, Agility™ offers the same performance as our Portability™ series instruments, but with the lowest size, weight, and power (SWaP) specifications in our lineup. This makes it exceptionally suited for scenarios where minimal footprint and maximum mobility are paramount. Each system is optimized for specific analytical tasks, offering custom specifications tailored to meet unique requirements.</strong></p><h4><strong>Technical specification</strong></h4><ul><li><strong>Detection Limit: </strong>Low parts-per-billion/ nanograms</li><li><strong>Mass Range:&nbsp;</strong><ul><li>m/z 40 — 500</li><li>m/z 80 — 1000</li></ul></li><li><strong>Mass Resolution: </strong>Unit</li><li><strong>Weight: </strong>7 kg (15 lbs.)</li><li><strong>Size: </strong>22.1 x 25.4 x 32.5 cm (8.7” x 10.0” x 12.8”)</li><li><strong>Average Power: </strong>100-240 VAC 50/60 Hz or 24 VDC, 80 W</li></ul>

BaySpec Ion-K9 Portable, Non-Contact Trace Vapor Detector

BaySpec Ion-K9 is the world’s first portable non-contact vapor detector using mass spectrometry. It delivers ppt-level sensitivity for real-time detection of explosives and narcotics in field and security applications.

<p><strong>Ion-K9 is a breakthrough portable system for non-contact, real-time detection of trace vapors of explosives and narcotics. It combines ppt-level sensitivity, a miniaturized linear ion trap mass analyzer, and non-radioactive ionization in a rugged, field-deployable platform designed for security and forensic operations.</strong></p><p>By enabling <strong>direct vapor detection without physical sampling</strong>, Ion-K9 significantly improves operator safety while accelerating screening of people, baggage, cargo, vehicles, and environments.</p><h4><strong>Key Features</strong></h4><ul><li>Non-contact vapor sampling</li><li>Ultra-high sensitivity down to <strong>9 pptv</strong></li><li>Simultaneous detection of explosives and narcotics</li><li>Positive and negative ion polarity</li><li>Miniaturized <strong>Linear Ion Trap</strong> mass analyzer</li><li>Non-radioactive ionization source</li><li><strong>&gt;99.999% threat detection</strong> with &lt;0.001% false alarm rate</li><li>Integrated PC with Windows 11</li><li>Audio-visual alarms with intuitive user interface</li><li>AC and battery operation</li><li>Designed and manufactured in the USA (ISO 9001:2015)</li></ul><h4><strong>Detected Substances</strong></h4><h5><strong>Explosives</strong></h5><ul><li>HMX, RDX</li><li>TNT, TNB, DNT, DNB, NT, NB</li><li>ADNT, DANT, TAT</li><li>DMNB</li><li>ETN, PETN</li><li>Tetryl</li><li>HNX (R-salt)</li><li>NG, EGDN</li><li>TATP, HMTD</li><li>Chlorates, perchlorates, nitrates</li></ul><h5><strong>Narcotics</strong></h5><ul><li>Cocaine</li><li>Fentanyl and analogs</li><li>Heroin</li><li>Ketamine</li><li>Methamphetamine, MDMA</li><li>Morphine, oxymorphone</li><li>Nitazenes</li><li>Benzodiazepines and precursors</li></ul><h4><strong>Technical Specifications</strong></h4><ul><li><strong>Sensitivity:</strong> down to 9 pptv</li><li><strong>Sampling method:</strong> non-contact vapor sampling</li><li><strong>Ion polarity:</strong> positive and negative</li><li><strong>Mass analyzer:</strong> miniaturized linear ion trap</li><li><strong>Ionization source:</strong> non-radioactive</li><li><strong>False alarm rate:</strong> &lt;0.001%</li><li><strong>Integrated computer:</strong> Intel Core i7, Windows 11</li><li><strong>Display:</strong> 10.1″ touchscreen LCD</li><li><strong>Dimensions:</strong> 20 × 15 × 15 in (51 × 38 × 38 cm)</li><li><strong>Weight:</strong> 39 lb (18 kg)</li><li><strong>Power:</strong> 100–240 VAC 50/60 Hz or 24 VDC, ~250 W, battery capable</li><li><strong>Operating temperature:</strong> −5 °C to 45 °C</li><li><strong>Operating humidity:</strong> 0–95% RH (non-condensing)</li><li><strong>Alarm system:</strong> audio-visual</li><li><strong>Output:</strong> clear threat / no-threat indication with detailed analytical data</li></ul><h4><strong>Typical Applications</strong></h4><ul><li>Airport and border security</li><li>Forensic and law enforcement investigations</li><li>Screening of personnel, baggage, and cargo</li><li>Critical infrastructure protection</li><li>Field detection of explosives and narcotics</li></ul>

BaySpec ESI Ionization Source

Electrospray Ionization (ESI) enables sensitive analysis of non-volatile, thermally labile compounds, producing multiply charged ions and supporting LC-MS workflows in portable MS systems.

<h4><strong>Ambient Ionization Sources for Portable Mass Spectrometers</strong></h4><p>BaySpec offers many types of ionization sources to use with our <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2219"><strong>Portability™</strong></a><strong> </strong>and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2218"><strong>Continuity™</strong></a> portable mass spectrometers. Delivering ultimate mobility and ease of use, BaySpec’s Portability™ and Continuity™ are compatible with ambient ionization techniques, which do not require any gases or tanks to run measurements. Making it ideal for field analysis, ambient ionization does not require sample preparation; sample introduction quick, direct, and easy to perform by anyone in any location. Providing flexibility to perform applications using various ionization techniques, the external ionization sources can also easily be swapped in less than a minute.</p><h4><strong>Key Features</strong></h4><ul><li>TD-ESI, ESI, TD-APCI, Swab-APCI, APCI, DBDI, and more</li><li>Ambient Ionization</li><li>No Tanks or External Pumps</li><li>No Sample Prep</li><li>Swappable</li><li>Field Analysis Ready</li><li>Real-time Results</li><li>Vapors, Liquids, Solids</li></ul><h4><strong>ElectroSpray Ionization (ESI)</strong></h4><p>Ideal for analyzing non-volatile and thermally labile molecules like proteins and peptides. It generates single and multiply<br>charged ions in positive and negative modes, operates efficiently at low flow rates, and integrates seamlessly with liquid chromatography systems. Features an optional thermal desorber for converting solid or liquid samples into vapors.</p>

BaySpec APCI Ionization Source

BaySpec ambient ionization sources enable fast, field-ready MS analysis without sample preparation. APCI is ideal for less polar compounds, delivering sensitive real-time results.

<h4><strong>Ambient Ionization Sources for Portable Mass Spectrometers</strong></h4><p>BaySpec offers many types of ionization sources to use with our <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2219"><strong>Portability™</strong></a><strong> </strong>and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2218"><strong>Continuity™</strong></a> portable mass spectrometers. Delivering ultimate mobility and ease of use, BaySpec’s Portability™ and Continuity™ are compatible with ambient ionization techniques, which do not require any gases or tanks to run measurements. Making it ideal for field analysis, ambient ionization does not require sample preparation; sample introduction quick, direct, and easy to perform by anyone in any location. Providing flexibility to perform applications using various ionization techniques, the external ionization sources can also easily be swapped in less than a minute.</p><h4><strong>Key Features</strong></h4><ul><li>TD-ESI, ESI, TD-APCI, Swab-APCI, APCI, DBDI, and more</li><li>Ambient Ionization</li><li>No Tanks or External Pumps</li><li>No Sample Prep</li><li>Swappable</li><li>Field Analysis Ready</li><li>Real-time Results</li><li>Vapors, Liquids, Solids</li></ul><h4><strong>Atmospheric Pressure Chemical Ionization (APCI)</strong></h4><p>Well-suited for less polar and some nonpolar molecules, generating primarily singly charged ions. APCI operates effectively without auxiliary gas and offers adjustable probe tip positioning for maximum sensitivity, supporting both positive and negative ion modes.</p>

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