<p><strong>Join us for a free two-day LECO Separation Science Workshop on September 23–24, 2026, at the </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/companies/219"><strong>C³AL Laboratory</strong></a><strong> at Cal State LA. Registration is free, and meals and refreshments will be provided throughout the workshop.&nbsp;</strong></p><h4><strong>Registration</strong></h4><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://forms.cloud.microsoft/pages/responsepage.aspx?id=iYeNbqIuykW7qZP4_jUEVbznDB40eK1PgjPzhHyb__9URTFTTFA5UEEzQ1A4MUtFV0o4TEJTNlZCOS4u&amp;route=shorturl"><strong>Register HERE</strong></a></p><p class="cke-user_style-important"><strong>Space is limited, register today!</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/LECO_LECO_Separation_Science_Workshop_registration_332543a18e.jpg" alt="LECO: LECO Separation Science Workshop - QR code for registration" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_LECO_LECO_Separation_Science_Workshop_registration_332543a18e.jpg 156w," sizes="100vw" width="437" height="437"></p></blockquote><h4><strong>Hand-on Experience with the LECO Complex Chemical Composition Analysis Lab C<sup>3</sup>AL</strong></h4><ul><li>Work directly with LECO instruments in the C<sup>3</sup>AL Laboratory</li><li>Learn complete analytical workflows from sample to answer</li><li>Get expert guidance from LECO application scientists</li><li>Develop methods and solve real-world challenges</li><li>Collaborate, ask questions, and build your skills</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Cal_State_LA_The_LECO_Pegasus_BTX_system_in_Cal_State_LA_s_LECO_Complex_Chemical_Compositional_Analysis_Lab_enhances_research_and_student_training_in_advanced_chemical_analysis_cover_b739e727ca.jpg" alt="Cal State LA: The LECO Pegasus BTX system in Cal State LA’s LECO Complex Chemical Compositional Analysis Lab enhances research and student training in advanced chemical analysis" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Cal_State_LA_The_LECO_Pegasus_BTX_system_in_Cal_State_LA_s_LECO_Complex_Chemical_Compositional_Analysis_Lab_enhances_research_and_student_training_in_advanced_chemical_analysis_cover_b739e727ca.jpg 227w," sizes="100vw" width="1252" height="863"></p><p>The first day will focus on the <strong>fundamentals and theory</strong> of comprehensive two-dimensional gas chromatography (<strong>GC×GC</strong>), with an emphasis on understanding how GC×GC can enhance your research, solve complex analytical challenges, and support your laboratory or company goals.&nbsp;</p><p>The second day will be dedicated to <strong>hands-on activities</strong>, giving participants the opportunity to work directly with <strong>LECO instrumentation</strong>, learn <strong>practical analytical workflows</strong>, and <strong>analyze their own samples</strong> with guidance from LECO application scientists.&nbsp;</p><p>Whether you are new to GC×GC or looking to expand its use in your research or organization, this workshop offers a unique opportunity to learn, explore, and apply the technology in a practical setting. Space is limited, so register early!</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Cal_State_LA_LECO_QUADJET_G_Cx_GC_coupled_to_Pegasus_BT_4_D_TOM_MS_in_the_Complex_Chemical_Composition_Analysis_Lab_C_AL_077a14ae34/Cal-State-LA-LECO-QUADJET-GCxGC-coupled-to-Pegasus-BT-4D-TOM-MS-in-the-Complex-Chemical-Composition-Analysis-Lab-(CAL).jpg" alt="Cal State LA: LECO QUADJET GCxGC coupled to Pegasus BT 4D TOM MS in the Complex Chemical Composition Analysis Lab (C³AL)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Cal_State_LA_LECO_QUADJET_G_Cx_GC_coupled_to_Pegasus_BT_4_D_TOM_MS_in_the_Complex_Chemical_Composition_Analysis_Lab_C_AL_077a14ae34/thumbnail_Cal-State-LA-LECO-QUADJET-GCxGC-coupled-to-Pegasus-BT-4D-TOM-MS-in-the-Complex-Chemical-Composition-Analysis-Lab-(CAL).jpg 234w," sizes="100vw" width="1949" height="1299"></p>

LECO Separation Science Workshop

<p><strong>We are delighted to invite food scientists from academia and industry, representatives of (inter)national agencies, control authorities, governmental and commercial laboratories to attend </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/928"><strong>RAFA 2026</strong></a><strong> (12th Symposium on Recent Advances in Food Analysis), that takes place 3–6 November 2026 in Prague..</strong></p><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://rafa.easyevent.eu/tickets/"><strong>SUBMIT ABSTRACT</strong></a> <strong>FOR POSTER PRESENTATION by August 31, 2026</strong></p><p>Do not miss the opportunity to present your latest results at <strong>RAFA 2026</strong>.</p></blockquote><h5><strong>Next deadlines:</strong></h5><ul><li><strong>August 31, 2026</strong>: 2nd window – &nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.rafa2026.eu/sponsors_exhibitors_media_partners_info.html"><strong>Application for participation as a Sponsor or Exhibitor</strong></a></li><li><strong>September 30, 2026:&nbsp;</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.rafa2026.eu/registration.html"><strong>Registration at the regular rate</strong></a></li><li><strong>Abstract submission</strong> – <strong>Last minute posters </strong>(<i>May not appear in the RAFA 2026 program</i>)</li></ul></li></ul><p>Since its first edition in 2003, RAFA has grown into a <strong>prestigious international event</strong>, typically welcoming <strong>up to 850 participants</strong> from more than <strong>60 countries</strong> worldwide, with the support of more than 50 sponsors, exhibitors, media and supporting partners.</p><p>RAFA 2026 will provide an overview of contemporary trends in the <strong>ANALYTICAL &amp; BIOANALYTICAL STRATEGIES IN FOOD QUALITY AND SAFETY CONTROL</strong> and discuss the <strong>CHALLENGES AND NOVEL APPROACHES IN FOOD AND NATURAL PRODUCTS ANALYSIS</strong>.</p><p>View the <a target="_blank" rel="noopener noreferrer" href="https://www.rafa2026.eu/invited_speakers.html"><strong>list of distinguished speakers</strong></a> who have accepted our invitation to RAFA 2026 and will present current hot topics and future perspectives in food analysis!</p><blockquote><p>👉More details on the <a target="_blank" rel="noopener noreferrer" href="https://www.rafa2026.eu/scientific_programme.html"><strong>RAFA 2026 preliminary program</strong></a> can be found HERE.</p><p>👉OUR <a target="_blank" rel="noopener noreferrer" href="https://www.rafa2026.eu/about_sponsors_exhibitors_partners.html"><strong>SPONSORS, EXHIBITORS, MEDIA and SUPPORTING PARTNERS</strong></a></p></blockquote><p>You are kindly invited to join and contribute to our exciting scientific program and unforgettable social events!</p><p><strong>We look forward to meeting you again in Prague!</strong></p><ul><li>Prof. Jana Pulkrabova &amp; Dr. Stefan van Leeuwen, Symposium Chairs</li><li>Prof. Michele Suman, Symposium Co-chair</li><li>Prof. Jana Hajslova &amp; Prof. Michel Nielen, Symposium Honorary Chairs</li></ul>

RAFA 2026 - Deadline for Abstract Submission for poster presentation is coming

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 17th August 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Shimadzu </strong>and <strong>Waters Corporation</strong>, brochure by<strong> Thermo Fisher Scientific </strong>and poster by<strong> MDCW / Arizona State University!</strong></p><h3><strong>1. MDCW / Arizona State University: Identifying Non-Biological Variance in Untargeted Analysis in Breath VOCs</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/P_8_Zabin_7786c8003b.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>When performing untargeted analyses for breath biomarker discovery, the goal is to identify biological signals in the breath chemistry that can help detect disease states, probe microbial interactions, and track environmental exposures. However, untargeted metabolomics and downstream data analysis workflows are vulnerable to signal contamination by non-biological variance associated with sample collection and handling and instrumental drift, which can obscure meaningful biological patterns.&nbsp;</p><h4><strong>Objective/Aims</strong></h4><p>The goal of this study is to identify and quantify non-biological variance in untargeted volatile metabolomics arising from sample collection procedures and instrumental drift.</p><h4><strong>Methods</strong></h4><p>Breath samples were collected and transferred onto Thermal Desorption Tubes (TDTs) in technical duplicates. TDTs were stored at 4˚C and analyzed using two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37"><strong>GC×GC– TOFMS</strong></a>).</p><h4><strong>Conclusions</strong></h4><p>Instrument drift and other non-biological factors can strongly affect metabolomics data. Consistent, timedependent patterns of dissimilarity highlight the need to identify and control these sources of variance to ensure reliable biomarker discovery.</p><h3><strong>2. Shimadzu: Analysis of Volatile PFAS in Textiles Using </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-TQ8040+RX"><strong>GCMS-TQ8040 RX</strong></a><strong> with MMI</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01257_en_beb993613a.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>User benefits</strong></h4><ul><li>Using the GCMS-TQ8040 RX and the Multi-Mode Injection Unit (MMI), 12 volatile PFAS including compounds listed in EN 17681-2,<br>can be analyzed at the ppb level without preconcentration.</li><li>The spike recovery test shows good percentage recoveries of all compounds (80–120 %) that are at or below the EU Persistent<br>Organic Pollutants (POPs) threshold limit (25 ppb)</li></ul><p>Per- and polyfluoroalkyl substances (PFAS) are used in textile products because of their useful properties, such as heat resistance and water repellency. However, PFAS are also extremely stable substances that resist degradation and accumulate in the environment, which has led to concerns about their effects on humans. Since eliminating sources of PFAS is essential to prevent them from accumulating in the environment and in living organisms, many countries are passing laws that restrict the production, distribution, and use of PFAS in products. For example, the EU POPs Regulation sets a permitted threshold of up to 0.025 mg/kg (25 ppb) for certain PFAS (including PFOA, PFOS, and PFHxS) in substances, mixtures, or articles1) . EN 17681 defines standard test methods for PFAS analysis in textiles2),3) .&nbsp;</p><p>In a previous <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01108_en_e04fe25939.pdf"><strong>Application News, No. 01-01108</strong></a>, an example of analyzing volatile and nonvolatile PFAS in textiles using LC/MS/MS and GC/MS/MS based on this standard was introduced. This study shows an example of trace analysis of volatile PFAS (Table1) in textiles using the newly developed GCMS-TQ RX series equipped with the Multi-Mode Injection Unit (MMI).</p><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-TQ8040+RX"><strong>GCMS-TQ8040 RX&nbsp;</strong></a></h4><p>Delivering highly sensitive multi-component simultaneous analysis, the system improves operational efficiency through Analytical Intelligence , while also providing performance as a single GC-MS. The GCMS-TQ RX Series is a versatile triple quadrupole GC-MS that demonstrates high performance across a wide range of application fields. By combining it with the newly developed Multi-Mode Injection Unit (MMI), multiple injection methods are supported and analytical capability is further expanded.</p><h4><strong>Multi-Mode Injection Unit (MMI)&nbsp;</strong></h4><p>The Multi-Mode Injection Unit (MMI) supports a wide range of injection modes in a single unit, including split/splitless (SPL), programmable temperature vaporization (PTV), large-volume injection (LVI), direct injection, and thermal desorption/extraction (TD/TE). Dedicated software with an intuitive user interface enables easy method creation and seamless method transfer, simplifying analytical workflows. In this Application News, use of the MMI enables a threefold increase the injection volume compared with conventional injection methods, while maintaining peak shape.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>Using the GCMS-TQ8040 RX and the MMI, volatile PFAS in textiles were analyzed. The results showed that all compounds measured in this study could be analyzed at 25 ppb or below. Furthermore, in the spike recovery test at the EU POPs regulatory limit of 25 ppb, recoveries were within 80 to 120 % for all compounds, showing good results. By increasing the injection volume with the MMI, trace levels of volatile PFAS can be measured even with the standard GCMS-TQ8040 RX model.</p><h3><strong>3. Thermo Fisher Scientific: Increase manufacturing productivity with handheld Raman analyzers</strong></h3><ul><li>Product specification</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tsg3_product_spec_en_c5faf63c57.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Raw material ID testing for pharmaceutical and biotechnology manufacturing quality control processes requires speed, ease and efficiency to maintain continuous manufacturing. Samples are often brought to a quality control lab for testing, increasing costs and decreasing productivity. The Thermo Scientific™ TruScan™ G3 Handheld Raman Analyzer enables non-technical operators to rapidly perform raw material ID testing without the need of a lab, bringing lab-quality performance and results to any setting, whether that be a warehouse or loading dock.&nbsp;</p><p>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=3&amp;search=TruScan+G3"><strong>TruScan G3 Handheld Raman Analyzer</strong></a> uses lab-proven Raman spectroscopy to perform rapid material identification at the point of need to decrease sampling costs and increase inventory turns. Designed for intuitive operation, its non-destructive point-and-shoot sampling principle facilitates rapid verification of a broad range of chemical compounds through sealed packaging to minimize the risk of contamination and exposure.&nbsp;</p><p>The TruScan G3 Handheld Raman Analyzer is built with a state-of-the-art optical platform paired with a field-proven embedded chemometrics engine. Our patented, multivariate residual analysis offers the most effective chemometric solution for material identification – with two spectral pre-processing options, that are easy to operate in challenging environments and sampling conditions.</p><h4><strong>Key features&nbsp;</strong></h4><ul><li>Non-destructive, point and shoot sampling through plastic bags, glass containers, blister packs and clear gel caps&nbsp;</li><li>Optional immersion probe for in-situ analysis and ergonomic comfort</li><li>Backwards compatibility with TruScan RM Handheld Raman Analyzer validated methods, makes TruScan G3 Handheld Raman Analyzer deployment a quick method transfer for a near seamless experience&nbsp;</li><li>A secured method for transferring of data via WIFI or wired connection for peace of mind&nbsp;</li><li>No frequent hardware maintenance nor consumables to operate are required&nbsp;</li><li>Digital data sign-off enhances 21 CFR Part 11 compliance&nbsp;</li></ul><h4><strong>Applications&nbsp;</strong></h4><ul><li>Incoming raw, in-process, or finished material identity verification&nbsp;</li><li>Identity check prior to dispensing of materials during manufacturing&nbsp;</li><li>Field or laboratory counterfeit drug identification</li></ul><h3><strong>4. Waters Corporation: Extending PFAS Analytical Workflows with APGC-MS/MS Analysis: A Method for 35 GC-Amenable PFAS Compounds</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009500_en_4b615b3bc2.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>Benefits&nbsp;</strong></h4><ul><li>An APGC-MS/MS method for the analysis of 35 GC-amenable PFAS allowing for characterization of PFAS samples beyond the suite of commonly targeted LC-MS/MS compounds, for a more complete assessment of PFAS burden</li><li>Injection of samples already extracted for LC-MS/MS analysis is possible without having to perform solvent exchange, saving time and labor &nbsp;</li><li>Sensitive and robust analysis to detect trace levels of PFAS in samples</li></ul><p>Routine PFAS analysis most commonly utilizes liquid chromatography (LC) as the separation technique and is the basis for most standardized methods that are currently available. While this is a key technique in the analysis of PFAS, there are classes of volatile and semi-volatile PFAS that do not chromatograph well using LC and require the use of gas chromatography (GC) to be successfully analyzed. Classes of PFAS that favor GC analysis include, but are not limited to, fluorotelomer alcohols (FTOH), fluorotelomer acrylates (FTAcr), fluorotelomer methacrylates (FTMAC), and fluorotelomer acetates (FTOAc). Additionally, there are classes that can be analyzed using both LC and GC techniques, including sulfonamides (PFSA) and sulfonamidoethanols (PFSE).&nbsp;</p><p>All of these compounds are considered precursor compounds that terminally transform into the most widely studied PFAS, perfluoroalkyl carboxylates (PFCA) and perfluoroalkyl sulfonates (PFSA). Not only are they precursors in the synthesis of PFCA and PFSA end products, they are also intentionally used in products such as food packaging and textiles to impart grease and water proofing qualities.&nbsp;</p><p>These precursor compounds are also discharged into the environment through similar routes as their end products (landfills, manufacturing waste, firefighting foams, etc), but also through volatilization, transport and deposition through the atmosphere either in the gas phase or bound to particulates. Like most PFAS, not much is known about the human toxicity of these particular PFAS, although some animal and in vitro studies do point to similar health effects as more commonly studied PFCAs and PFSAs, including liver and kidney toxicity, endocrine disruption and negative immune effects.1-4 Furthermore, their ability to transform in the environment to PFCAs and PFSAs, which are known to have toxic health implications, make them of concern.&nbsp;</p><p>GC-MS/MS analysis for the volatile and semi-volatile GC amenable PFAS provides an additional tool in the workflow of PFAS sample analysis, increasing the comprehensiveness of sample characterization. In this application note, the development of an atmospheric pressure gas chromatography (APGC) coupled to tandem quadrupole mass spectrometry (MS/MS) method will be presented. Application of this method to authentic samples will be explored in a companion application note.</p><h4><strong>Experimental</strong></h4><ul><li><strong>GC system:</strong> <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890"><strong>Agilent 8890&nbsp;</strong></a></li><li><strong>Autosampler:</strong> <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7693A"><strong>7693A ALS</strong></a></li><li><strong>MS system:</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/554"><strong>Xevo™ TQ Absolute Mass Spectrometer&nbsp;</strong></a></li><li><strong>Ionization mode:</strong> API+</li></ul><h4><strong>Conclusion&nbsp;</strong></h4><p>An optimized APGC-MS/MS method for the analysis of 35 GC amenable PFAS has been presented, providing a practical way to extend existing workflows with sensitive and accurate analysis for fluorotelomer alcohols, acrylates, methacrylates, acetates, sulfonamides and sulfonamidoethanols. This approach could integrate seamlessly with existing LC-MS/MS workflows, allowing labs to extend compound coverage without requiring changes to established sample preparation protocols. Performance for all compounds was found to be optimal with the use of a siltek deactivated inlet liner and a 30 m x 0.25 mm ID, 0.50 µm Rtx-200 column. This configuration allows for the injection of samples pre-extracted for LC-MS/MS analysis that are in mainly methanol and water, allowing labs to generate additional insights without increasing sample prep burden. Method LLOQs ranged from 0.005 – 5.0 ng/mL, with most compounds being below 0.10 ng/mL, delivering robust performance across compound classes, indicating the method can be used for trace level applications. Overall, APGC-MS/MS adds a complementary capability to LC-MS/MS methods, allowing labs to comprehensively assess PFAS contamination for better understanding and informed regulatory or product safety decisions. Further application notes will demonstrate the use of this method in environmental and food packaging samples, highlighting how labs can gain more complete PFAS insights while leveraging existing workflows.</p></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 34, 2026

Article

Events

Application

Food

Poster

RAFA provides an overview of contemporary trends in ANALYTICAL & BIOANALYTICAL STRATEGIES IN FOOD QUALITY AND SAFETY CONTROL and discusses CHALLENGES / NOVEL APPROACHES IN FOOD AND NATURAL PRODUCTS ANALYSIS.

Recent Advances in Food Analysis (RAFA)

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

In 1936, the Laboratory Equipment Company introduced the first rapid carbon determinator for the American iron and steel industry.  Today, almost 80 years later, LECO is recognized globally as a leader in the development of high-quality analytical instrumentation, mass spectrometers, comprehensive two-dimensional chromatography, metallography & optical equipment as well as consumables.

LECO

Waters CERTIFIED HPLC Vials

Reducing failed assays from unknown contaminant peaks and limiting instrument downtime from out of specification vials is a priority for your lab. Waters sample vials can help you do just that.

<div><div><h4><strong>Meet your analytical challenges with the right vial.</strong></h4></div></div><div><div><p><strong>The right vial.&nbsp;</strong><span><strong>A world of difference.</strong></span></p><p>Reducing failed assays from unknown contaminant peaks and limiting instrument downtime from out of specification vials is a priority for your lab. Waters sample vials can help you do just that.</p><p>All Waters sample vials are held to the tightest dimensional tolerances. Manufactured via a 2-, 3-, or 4-step certification process, we ensure that Waters Certified Vials meet and maintain specified vial dimensions, levels of cleanliness and adsorption properties from batch to batch.&nbsp;Find the right vial for your application and autosampler - use our <a target="_blank" rel="noopener noreferrer" href="https://find.waters.com/VialSelector/"><strong>Vial Selector</strong></a> to find your perfect match.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_118649175c.jpg" alt="Waters CERTIFIED Vials: Table 1. Vials for Routine and Advanced Analyses." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_118649175c.jpg 245w," sizes="100vw" width="1226" height="754"></p><h3><strong>Waters LCMS CERTIFIED</strong></h3><p><span><strong>✅ </strong></span>Dimensional Test</p><p><span><strong>✅ </strong></span>Septum GC Test</p><p><span><strong>✅ </strong></span>HPLC UV Test</p><p><span><strong>✅ </strong></span>MS Scan</p><ul><li>Low MS interferences from known residues &amp; polymers</li><li>For routine QC and LC-MS analysis with lower analyte concentrations from 10-100s ng/ml.</li></ul><h3><strong>Waters TruView<sup>TM</sup> LCMS CERTIFIED</strong></h3><p><span><strong>✅ </strong></span>Dimensional Test</p><p><span><strong>✅ </strong></span>Septum GC Test</p><p><span><strong>✅ </strong></span>HPLC UV Test</p><p><span><strong>✅ </strong></span>MS Scan</p><p><span><strong>✅&nbsp;</strong></span>Low Adsorption Test</p><div><div><ul><li>Lowest MS interferences from known residues &amp; polymers</li><li>For high-end LC-MS analysis and quantification of analytes with a concentration of below 1 ng/ml with reduced adsorption of polar analytes.</li></ul><h3><strong>Waters CERTIFIED</strong></h3><p><span><strong>✅ </strong></span>Dimensional Test</p><p><span><strong>✅ </strong></span>Septum GC Test</p><p><span><strong>✅ </strong></span>HPLC UV Test</p><div><div><ul><li>No UV interferences caused caused by manufacturing and packaging residues</li><li>For routine QC LC-UV analysis&nbsp;of compounds in µg/mL&nbsp;concentrations.&nbsp;</li></ul><h3><strong>MAXPEAK QuanRecovery</strong></h3><ul><li>For high recovery peptide and protein quantification workflows. Reduces sample losses due to non-specific binding (NSB) and ionic interactions.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_2_4fba532335.jpg" alt="Waters CERTIFIED Vials: Vials Shapes." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_2_4fba532335.jpg 245w," sizes="100vw" width="1261" height="617"></p><div><div><h3><strong>Control data quality risks and reduce unexpected or ghost peaks</strong></h3><p>Don’t let the presence of background noise impact your results, causing data quality risks and unexpected or ghost peaks. Background noise can come from many factors.&nbsp;One of the most important factors are vial and septa cleanliness, which introduces contamination peaks. Ghost peaks are introduced by analyte degradation that can be triggered by significant pH changes in the diluent. In this chromatogram, the top shows normal behavior, and the bottom chromatogram shows ghost peaks.</p><p>Waters Certified vials are cleanliness tested so you don’t have to worry about contaminant peaks. The TruView pH Control Vials are certified to minimize and control a pH shift away from the neutral.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_4_7749301ba1.jpg" alt="Waters CERTIFIED Vials: Prevent the appearance of unexpected peaks during LC/UV analysis with Waters LC/GC Certified Vials as a control strategy." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_4_7749301ba1.jpg 245w," sizes="100vw" width="1024" height="535"></p><h3><strong>More time on development. Less on troubleshooting</strong></h3><p>Stop losing valuable development time on troubleshooting due to analyte loss from non-specific adsorption. Waters TruView pH Control LCMS Certified Vials have the lowest adsorptive losses on the market, and you can rely on them to provide consistency from batch to batch and vial to vial. This chromatogram shows a comparison of adsorptive loss of chlorhexidine in a variety of vials.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_5_d3e42fa7f2.jpg" alt="Waters CERTIFIED Vials: Comparison of adsorptive loss of chlorhexidine acetate in a variety of vials." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_5_d3e42fa7f2.jpg 245w," sizes="100vw" width="1024" height="633"></p><div><div><h3><strong>Ideal for demanding MS work</strong></h3><p>LCMS Certified Vials are suited for analyte concentrations in the 100s ng/mL concentration. Waters LCMS Certified Vials are tested by MS scans from 250 to 1000 <i>m/z</i> with specifications set on the total ion count and presence of clusters in the high mass range. This chromatogram shows a comparison of typical MS scans of Waters LCMS Certified Vials to vials of other sources and clean solvents.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_3_4869fbf57a.jpg" alt="Waters CERTIFIED Vials: Comparing typical MS scans of Waters LCMS Certified Vials, with vials from other sources." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_3_4869fbf57a.jpg 245w," sizes="100vw" width="1024" height="406"></p><div><div><h3><strong>Stay in control of your samples' pH</strong></h3><p>The analysis of low abundance species, pH sensitive analytes or not yet well understood compound mixtures benefit from consistent and well controlled vial surfaces. The glass surface of TruView pH Control LCMS Certified Vials minimizes pH shifts away from the neutral and thus eliminates unwanted reactions and resulting ghost peaks.&nbsp;Ghost peaks are very difficult to troubleshoot.</p><p>Waters TruView pH Control LCMS Certified vials were used to analyze two compounds, drospirenone and lovastatin. The TruView pH Control LCMS Certified Vials show little to no degradant formed over the time tested. Standard glass vials showed considerable degradant formation over the same testing time with irreproducible formation of the degradant across different vials.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_6_4dc330d849.jpg" alt="Waters CERTIFIED Vials: UV peak areas of lovastatin degradant across replicate vials and different vial types. Error bars indicate standard deviation for the replicate injection peak area." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_6_4dc330d849.jpg 245w," sizes="100vw" width="1024" height="605"></p><div><div><h3><strong>Reducing adsorption starts here</strong></h3><p>Inconsistent analytical results from small molecule analyte adsorption onto the surface of glass vials can be a problem at today’s low analyte concentrations. Some scientists have even experienced total analyte loss with samples stored in vials for an extended time. The vial chemistry, specifically the&nbsp;glass surface, is the major contributor to this problem.</p><p>Polar analytes&nbsp;may adsorb to the glass vial surface by polar-polar interaction and/or ion exchange mechanisms, thereby reducing the overall amount of sample in solution. TruView Certified LCMS Vials&nbsp;reduce this problem dramatically due to a stringent manufacturing process. The process yields a glass surface that has a lower concentration of free ions on the surface.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_CERTIFIED_Vials_8_064003b933.jpg" alt="Waters CERTIFIED Vials: Nortriptyline at 1 ppb concentration in several vials. The tall peak is the initial injection; the smaller peak (overlaid) is the four-hour injection. The first two chromatograms are competitor’s vials. The third chromatogram is for the Waters TruView LCMS Certified vial. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_CERTIFIED_Vials_8_064003b933.jpg 245w," sizes="100vw" width="1912" height="1182"></p><div><div><h3><strong>No analyte left behind</strong></h3><p>Instrument development is yielding more sensitive mass spectrometers. With more sensitive instruments, analytes can be detected at pg/mL levels. At these concentrations, understanding adsorption issues is critical for good quantitative results. We tested adsorption loss for the major manufacturers and saw high sample loss across manufacturers and clear and amber glass types – with significantly less loss with Waters TruView Autosampler Vials.</p><h4><strong>Average Analyte Loss</strong></h4><p><strong>Manufacturer: Clear Glass / Amber Glass</strong></p><ul><li><strong>Vendor A</strong>: 55% / 69%</li><li><strong>Vendor B</strong>: 25% / 25%</li><li><strong>Vendor C</strong>: 54% / 74%</li><li><strong>Vendor D</strong>: 18% / 59%</li><li><strong>Vendor E</strong>: 75% / Not tested</li><li><strong>Waters TruView LCMS Certified Vial</strong>: 1% / 6%</li></ul></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific QuEChERS Sample Preparation Kits

QuEChERS is a versatile sample preparation method for analyzing pesticides, veterinary drugs, and other residues in various sample types before GC-MS or LC-MS analysis.

<div><div><div><h3><strong>QuEChERS sample preparation—now easier, more convenient, and affordable</strong></h3><p><strong>QuEChERS</strong> (<strong><u>Q</u></strong><u>u</u>ick, <strong><u>E</u></strong>asy, <strong><u>C</u></strong>heap, <strong><u>E</u></strong>ffective, <strong><u>R</u></strong>ugged, and <strong><u>S</u></strong>afe)is a <strong>sample preparation method</strong> that was initially developed in 2003 for <strong>analyzing veterinary drugs in food</strong>. The method was also tested for <strong>pesticide residue analysis in plant material</strong> with great success. In 2003, the <strong>detailed method was published</strong> in the journal AOAC International. Since then, the QuEChERS method has evolved into a <strong>sample preparation technique used on a variety of analytes</strong> in an <strong>expanding number of sample types</strong> before analysis by <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/gas-chromatography-mass-spectrometry-gc-ms.html"><strong>GC-MS</strong></a><strong> or </strong><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms.html"><strong>LC-MS</strong></a>.</p><p><strong>Thermo Scientific QuEChERS kits</strong> contain <strong>pre-packaged, ready-weighed salts, sorbents, and buffers</strong> to <strong>streamline your workflow</strong> and <strong>minimize the potential for error</strong>. The kits are grouped according to your <strong>analytes of interest</strong>, <strong>sample matrix</strong>, and <strong>preferred QuEChERS method</strong>:</p><ul><li><strong>Original 2003 Method</strong></li><li><strong>AOAC 2007.01 Method</strong></li><li><strong>EN 15662 Method</strong></li><li><strong>NY/T 1380-2007 Method</strong></li></ul><p><strong>Complete packages</strong>—including both <strong>extraction and clean-up kits</strong>—are available. <strong>Extraction-only and cleanup-only kits</strong> are also offered to suit your laboratory’s sample preparation needs. These <strong>pre-packaged kits save time and money</strong>, make QuEChERS procedures <strong>easier and more convenient</strong>, and ensure <strong>quality to yield reproducible results</strong> and <strong>excellent recoveries</strong> for a wide variety of analytes.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Qu_E_Ch_ERS_Sample_Preparation_Kits_2_1e99f0c81b.jpg" alt="Thermo Scientific QuEChERS Sample Preparation Kits" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Qu_E_Ch_ERS_Sample_Preparation_Kits_2_1e99f0c81b.jpg 217w," sizes="100vw" width="891" height="640"></p><h3><strong>Typical QuEChERS workflow</strong></h3><div><div><div><div><div><p>As shown in the workflow diagram below, the <strong>QuEChERS method has four basic steps</strong>:</p><ol><li><strong>Homogenize sample</strong> (fruit or vegetable)</li><li><strong>Extract analytes of interest</strong> from a sample using <strong>extraction salts</strong> (pesticide residues, veterinary drugs, and/or mycotoxins)</li><li><strong>Clean-up the resulting supernatant</strong> using <strong>dispersive solid phase extraction (dSPE)</strong></li><li><strong>Analyze by GC-MS or LC-MS</strong></li></ol><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Qu_E_Ch_ERS_Sample_Preparation_Kits_496491ceff.jpeg" alt="Thermo Scientific QuEChERS Sample Preparation Kits" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Qu_E_Ch_ERS_Sample_Preparation_Kits_496491ceff.jpeg 245w," sizes="100vw" width="1170" height="706"></p><div><h3><strong>QuEChERS products</strong></h3></div><div><h4><strong>QuEChERS extraction kits for original 2003 method</strong></h4></div><div><p>The <strong>original QuEChERS method</strong> (Anastassiades et al, 2003) was developed by <strong>Steven J. Lehotay and Michelangelo Anastassiades</strong> in 2003 for the <strong>determination of pesticide residues in fruits and vegetables</strong>. The original method was created to <strong>analyze non-base-sensitive compounds</strong> and uses a <strong>sodium chloride buffer</strong> to <strong>reduce polar interferences</strong> and <strong>enhance extraction</strong>. <strong>Buffering</strong> is an important part of the QuEChERS procedure because it <strong>allows for analysis of pesticides and other residues</strong> that display <strong>pH dependence in their recoveries</strong>, depending on the <strong>sample matrix</strong>. <strong>Three different extraction kits</strong> are available to support the <strong>original 2003 QuEChERS method</strong>.</p><h5><strong>Chemicals used in the original 2003 method</strong></h5></div><ul><li><strong>Acetonitrile:</strong> Used to perform single-phase extraction (SPE) on a sample</li><li><strong>Anhydrous MgSO₄:</strong> Induces phase separation between water content in sample and acetonitrile layer during liquid-liquid partitioning step; removes remaining water from sample during dispersive solid phase extraction (dSPE) step</li><li><strong>NaCl:</strong> Induces phase separation between water content in sample and acetonitrile layer during liquid-liquid partitioning step; removes residual water from sample; reduces polar interference and enhances extraction</li><li><strong>PSA:</strong> Primary secondary amine, used to remove polar matrix components, citric co-extractives, and free fatty acids, from sample during dispersive solid phase extraction (dSPE) step</li></ul><div><h4><strong>QuEChERS extraction and clean-up kits for AOAC 2007.01 method</strong></h4><p>The <strong>AOAC 2007.01 QuEChERS Method</strong> was developed by <strong>Steven J. Lehotay and his co-workers</strong>, who <strong>modified the original 2003 method</strong> to accommodate the use of <strong>acetate buffering at higher concentration</strong> for <strong>greater buffering strength</strong>. <strong>Buffering</strong> is an important part of the QuEChERS procedure because it <strong>allows for analysis of pesticides and other residues</strong> that display <strong>pH dependence in their recoveries</strong>, depending on the <strong>sample matrix</strong>. These <strong>extraction and clean-up products</strong> here support the <strong>AOAC 2007.01 method</strong>.</p><div><h5><strong>Chemicals used in the AOAC 2007.01 method</strong></h5><ul><li><strong>Acetonitrile:</strong> Used to perform single-phase extraction on a sample</li><li><strong>Anhydrous MgSO₄:</strong> Induces phase separation between water content in sample and acetonitrile layer during liquid-liquid partitioning step; removes remaining water from sample during dispersive solid phase extraction (dSPE) step</li><li><strong>NaOAc:</strong> Buffers the sample to stabilize pH</li><li><strong>PSA:</strong> Primary secondary amine, used to remove polar matrix components, citric co-extractives, and free fatty acids, from sample during dispersive solid phase extraction (dSPE) step</li><li><strong>C18:</strong> Removes fats, sterols, and other non-polar interferences from sample</li><li><strong>GCB:</strong> Graphitized carbon black, removes pigment (<i>not recommended for use with planar pesticides</i>)</li></ul><div><h4><strong>QuEChERS extraction and clean-up kits for EN 15662 method</strong></h4><p>The <strong>extraction and clean-up products</strong> here support the <strong>EN 15662 method</strong>. <strong>Widely used in Europe</strong>, the EN 15662 method was developed by <strong>Michelangelo Anastassiades and co-workers</strong>, who <strong>modified the original 2003 method</strong> to accommodate the use of <strong>citrate buffering at a relatively low buffering capacity</strong>. This variation uses a <strong>sodium chloride buffer</strong> to <strong>minimize polar interferences</strong> in addition to <strong>sodium citrate dihydrate</strong> and <strong>disodium citrate sesquihydrate buffers</strong>. <strong>Buffering</strong> is an important part of the QuEChERS procedure because it <strong>allows for analysis of pesticides and other residues</strong> that display <strong>pH dependence in their recoveries</strong>, depending on the <strong>sample matrix</strong>.</p><h5><strong>Chemicals used in the EN 15662 method</strong></h5><ul><li><strong>Acetonitrile:</strong> Used to perform single-phase extraction on a sample</li><li><strong>Anhydrous MgSO₄:</strong> Induces phase separation between water content in sample and acetonitrile layer during liquid-liquid partitioning step; removes remaining water from sample during dispersive solid phase extraction (dSPE) step</li><li><strong>NaCl:</strong> Induces phase separation between water content in sample and acetonitrile layer during liquid-liquid partitioning step; removes residual water from sample</li><li><strong>Trisodium Citrate:</strong> Buffers the sample to stabilize pH</li><li><strong>Disodium Citrate Sesquihydrate:</strong> Buffers the sample to stabilize pH</li><li><strong>PSA:</strong> Primary secondary amine, used to remove polar matrix components, citric co-extractives, and free fatty acids, from sample during dispersive solid phase extraction (dSPE) step</li><li><strong>C18:</strong> Removes fats, sterols, and other non-polar interferences from sample</li><li><strong>GCB:</strong> Graphitized carbon black, removes pigment (<i>not recommended for use with planar pesticides</i>)</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Qu_E_Ch_ERS_Sample_Preparation_Kits_3_721562526f.jpg" alt="Thermo Scientific QuEChERS Sample Preparation Kits" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Qu_E_Ch_ERS_Sample_Preparation_Kits_3_721562526f.jpg 245w," sizes="100vw" width="1471" height="488"></p><div><h4><strong>QuEChERS clean-up kit for NY/T 1380-2007 method</strong></h4></div><div><p>The <strong>NY/T 1380-2007 method</strong> is <strong>recommended by China Ministry of Agriculture</strong> for the <strong>QuEChERS Method sample preparation</strong> of <strong>51 specific pesticide residues</strong> in <strong>fruits and vegetables</strong> with <strong>analysis by GC-MS</strong>.</p><h5><strong>Chemicals used in the NY/T 1380-2007 method</strong></h5><ul><li><strong>Anhydrous MgSO₄:</strong> Induces phase separation between water content in sample and acetonitrile layer during liquid-liquid partitioning step; removes remaining water from sample during dispersive solid phase extraction (dSPE) step</li><li><strong>PSA:</strong> Primary secondary amine, used to remove polar matrix components, citric co-extractives, and free fatty acids, from sample during dSPE step</li><li><strong>C18:</strong> Removes fats, sterols, and other non-polar interferences from sample</li></ul></div></div></div></div></div></div></div></div></div></div></div></div>

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