<blockquote>Welcome back to the topic of protecting your GC column! If you missed part 1 or would like to refresh your knowledge, find further tips on GC column protection <a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/knowledge-center/gc-knowledge-center/protecting-your-gc-column-pt1-tech-tip-en-1025">here.</a></blockquote>Protecting your GC column and instrument components from exposure to dirty samples or contaminants is important. Non-volatile or high molecular weight components can contaminate the stationary phase, causing poor peak resolution, lower accuracy, and poor column lifetime. Cutting off the damaged portion of column tubing will often restore your column’s performance, but over time performance will degrade to a point where the column can no longer be used. If you are experiencing rapid degradation of column performance, there are several simple ways to help protect your column and increase its lifetime.<h3>Use A Liner With Wool</h3>The liner is the first line of defense for your column, and the style you choose can make a big impact in how much contamination gets onto the column. The easiest thing to do is to add a small amount of silanized glass wool to a liner, which traps the non-volatile compounds and prevents them from entering directly into the column.&nbsp;<blockquote>Caution: glass wool can also add activity for acids, bases, and pesticides. Crushing the glass wool can expose undeactivated glass and free silanols (-OH groups) even if the wool has been deactivated. This leads to increased activity, so pre-packed liners, rather than self-packed ones are highly recommended to avoid reproducibility issues.</blockquote>In addition to choosing a liner with wool, ensure that your liner (and other system consumables) are free of contaminant build-up that may form over time. Septum cores and other particulates that remain can become trapped in the wool and are sometimes difficult to spot. Regularly replace the liner (and other system consumables as needed) to reduce troubleshooting and maintenance.<h3>Bake Out Your Column</h3>The easiest way to reduce column contamination is to add a short, high temperature bake-out at the end of your standard GC method. This bake out helps remove high boiling contaminants that would otherwise remain in the column and cause damage. To bake out, the final oven temperature needs to be set high enough to ensure elution of these compounds, but not so high as to cause thermal damage. This can be done either isothermally, or more commonly, via an oven ramp until the last components elute from the column. Caution: NEVER exceed the upper temperature limits of your column. DO NOT exceed more than fifteen minutes at the upper isothermal temperature limit specified for the column.

How to Protect Your GC Column - Part 2

🎤 Presenter: Christopher Freye (Los Alamos National Laboratory)💾 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_1_Freye_10783a9cf3.pdf">PDF presentation</a><h3>Abstract</h3>Two-dimensional gas chromatography (<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?instrumentationItems=2">GC×GC</a>) when coupled with mass spectrometry (MS) especially high-resolution mass spectrometry (HRMS) provides the ideal technique to discover minute chemical changes. However, GC×GC analyses result in extremely large datasets (GBs of information) wherein the statistically significant chemical changes are buried within the background chemical matrix. To combat these issues, many chemometric techniques have been developed or applied. Recently we introduced a new chemometric technique for GC-MS termed alteration analysis (ALA) and two-dimensional correlation (2DCOR) which can be used to discover statistically significant chemical changes across a series of chromatograms and understand the relationship between the statistically relevant changes. ALA generates three sets of information, the basic alteration map (BAM) which is the magnitude of the change, the synchronous alteration map (SAM) which describes the linear change, and the asynchronous alteration map (AAM) which describes the non-linear change. 2DCOR can then be used to understand the relationship between the chemical changes but 2DCOR can also resolve the sequence of the changes. A workflow for GC×GC-MS will be demonstrated. Special attention will be given to what differentiates the GC×GC work flow from GC for both the ALA and 2DCOR.<h3>Video Transcription</h3>The presentation focuses on how advanced mathematical and chemometric methods can be used to extract meaningful information from highly complex chromatographic data, especially in multidimensional chromatography coupled with mass spectrometry (GC×GC-MS, LC-MS).<h4>Why traditional data analysis falls short</h4>Modern multidimensional chromatography generates extremely large datasets, often containing billions of data points. Visual inspection, peak tables, or classical identification-based workflows are impractical—especially when:<ul><li>Samples are highly complex (e.g. petroleum, metabolomics, high explosives)</li><li>Most compounds are unknown unknowns</li><li>The key question is not what the compounds are, but whether samples differ and how</li></ul>Program managers and decision-makers are primarily interested in detecting statistically significant changes, not exhaustive compound identification.<h4>Introduction of Alteration Analysis (ALA)</h4>To address subtle, trend-based changes across series of chromatograms, the speaker introduces Alteration Analysis (ALA), a chemometric approach adapted from spectroscopy and applied to chromatography.ALA quantitatively evaluates how individual data points change across multiple samples, allowing detection of:<ul><li>Extremely subtle trends</li><li>Overlapping peaks</li><li>Changes hidden in noise or baseline interference</li></ul>Key ALA outputs include:<ul><li>BAM (Basic Alteration Map): magnitude of change</li><li>SAM (Systematic Alteration Map): linear changes</li><li>AM (Alteration Map): nonlinear changes</li></ul>Even changes as small as 1% per sample can be detected reliably, including peaks that are heavily overlapped.<h4>Beyond detection: understanding relationships with 2D Correlation</h4>Once statistically significant changes are identified, two-dimensional correlation analysis (2D-COR) is used to understand relationships between changing compounds, including:<ul><li>Whether compounds are correlated or anti-correlated</li><li>The sequence of changes over time (which changes happen first)</li></ul>This is especially critical for degradation and aging studies, where intermediate species may appear and disappear before the final state—information that traditional methods like Fisher ratio or PCA often miss.<h4>Solving GC×GC challenges with tiling</h4>GC×GC data introduces additional challenges due to:<ul><li>Peak misalignment</li><li>Exponential data growth during correlation calculations</li></ul>The presenter explains how tile-based approaches reduce data dimensionality, overcome alignment issues, and make ALA and 2D correlation computationally feasible—even for massive GC×GC-MS datasets.<h4>Real-world application: explosive aging studies</h4>The methodology was applied to aging and decomposition of high explosives, where:<ul><li>Over 250 chemical changes were identified</li><li>Many intermediate species would have been missed using traditional comparisons</li><li>ALA combined with 2D correlation enabled reconstruction of degradation pathways</li><li>The most significant change was not necessarily the first change, a critical insight for risk assessment and stability studies</li></ul><h4>Key takeaway</h4>By combining Alteration Analysis and 2D correlation, the approach:<ul><li>Detects statistically guaranteed chemical changes</li><li>Handles subtle, overlapped, and noisy signals</li><li>Determines magnitude, type, interrelationships, and order of changes</li><li>Shifts chromatographic data analysis from identification-driven to decision-driven</li></ul>This math-driven workflow enables faster, more reliable interpretation of complex chromatographic datasets and provides actionable insights for applications such as explosive aging, pharmaceutical degradation, and complex mixture analysis.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote>

Discovery analysis for GCxGC trends using alteration and 2D correlation (Chris Freye, MDCW 2026)

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 9th February 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you technical note by Agilent Technologies, presentation by MDCW / University of Copenhagen and application notes by Shimadzu and Thermo Fisher Scientific!<h3>1. Agilent Technologies: What Causes Spots on <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?instrumentationItems=19&amp;manufacturerItems=1&amp;search=PLOT">PLOT Columns</a>? Will It Affect the Performance of the Column?</h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_what_causes_spots_plot_columns_affecting_performance_5994_8775en_agilent_3b7180512a.pdf">Full PDF for download</a></li></ul>Spots on porous layer open tubular (PLOT) columns are caused by small voids in the stationary phase coating inside the tube. These spots are areas where there is an uneven coating or lack of phase. It is normal to find some voids in the phase coating of PLOT columns. The stationary phase in PLOT columns is an opaque, solid, and porous material. In many Agilent PLOT columns such as the GS-Alumina phases, molecular sieves, porous polymers (Q and U), and the GS-OxyPLOT, the stationary phase is visible as a white powder. For many PLOT columns, the stationary phase fill solution is a viscous suspension of particles that are less than 10 microns in diameter. The phase is coated using a dynamic process in which a plug of fill solution is pushed through the tubing, and the plug’s speed and viscosity determines the thickness of the stationary phase layer. Once the PLOT’s stationary phase is deposited, it is held in place by electrostatic charge, chemical interactions between particles, and/or binding agents. In wall‑coated open tubular (WCOT) columns, stationary phases such as polysiloxanes or polyethylene glycols are immobilized by chemical bonding to the glass surface and cross-linking between polymer strands. Because this type of bonding and cross‑linking is not possible with PLOT phases, the result is a stationary phase layer that is both fundamentally different and inherently less stable in PLOT columns than in WCOT&nbsp;columns.<h3>2. MDCW / University of Copenhagen: One-shot tensor decomposition of full-scale GC×GC-VUV datasets for resolving petrochemical groups</h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_17_Schneide_67c8ff7866.pdf">Full PDF for download</a></li></ul>The presentation introduces a novel all-samples-at-once, shift-invariant tri-linear tensor decomposition approach for the analysis of full-scale <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?search=GC%C3%97GC-VUV">GC×GC-VUV</a> datasets, aimed at resolving and quantifying petrochemical groups. Traditional template-based or pixel-based methods struggle with retention-time shifts and co-eluting compounds, often requiring manual intervention and prior chemical knowledge. The proposed approach leverages the intrinsic low-rank structure of GC×GC-VUV data to enable robust, automated group-level analysis across multiple samples simultaneously.At the core of the method is a shift-invariant tri-linear model, conceptually related to PARAFAC and multivariate curve resolution, but extended using frequency-domain (FFT-based) modeling to explicitly account for chromatographic peak shifts. By decomposing the entire dataset in one step, the model provides accurate estimates of peak landscapes, VUV spectra, and relative peak areas, while remaining agnostic to retention-time variability. Importantly, the approach requires only a small number of tunable parameters, making it practical for routine use.The method was demonstrated on a case study involving 14 petrochemical gas-oil samples, including straight-run, hydrotreated, hydroconverted, coker, and light cycle oils. Extracted VUV spectra showed excellent agreement with reference spectra from a VUV spectral database, enabling confident assignment of components to chemical groups such as saturates, olefins, and mono- to poly-aromatics. Quantitative results exhibited high repeatability (RSD typically 3–9%) and strong correlation with established template-based reference methods.Overall, the work demonstrates that one-shot, shift-invariant tensor decomposition provides a powerful and scalable alternative to conventional GC×GC data-analysis strategies. By combining chemical interpretability, robustness to chromatographic shifts, and strong quantitative performance, the approach opens new opportunities for automated, high-confidence group-level analysis of complex petrochemical samples and beyond.<h3>3. Shimadzu: Py-Screener Ver. 3: Simultaneously Test for Substances Regulated Under RoHS, TSCA, and POPs</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00949_en_4754e50164.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>In just one analysis, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=Py-Screener">Py-Screener</a> Ver. 3 can determine levels of phthalate esters, brominated flame retardants (PBBs, PBDEs), PIP (3:1), UV-328, dechlorane plus (DP), short-chain chlorinated paraffins (SCCPs), and medium-chain chlorinated paraffins (MCCPs).&nbsp;</li><li>It can also test for SCCPs and MCCPs by electron ionization (EI) instead of negative chemical ionization (NCI).&nbsp;</li><li>PIP (3:1), UV-328, DP, and SCCPs and MCCPs can be screened without the need for corresponding reference materials.</li></ul>Countries and regulatory bodies worldwide are introducing increasingly stringent regulations on the chemical substances used in electronic devices and industrial products. The RoHS Directive and REACH regulations in the EU, the Toxic Substances Control Act (TSCA) in the USA, and the Stockholm Convention on Persistent Organic Pollutants (POPs) are also targeting an increasingly broad range of substances. Therefore, manufacturers are required to accurately identify regulated substances in their products and comply with each regulation. While Py-Screener Ver. 2 can screen for seven phthalate esters and brominated flame retardants, including substances regulated under the RoHS Directive, version 3 can also screen for PIP (3:1), which is regulated under the TSCA, as well as UV328, DP, and SCCPs and MCCPs , which are regulated under the Stockholm Convention on POPs. A list of supported substances isshown in Table 1. This article introduces the simultaneous analysis of multiple regulated substances and a case study of testing specific regulated substances in samples, using Py-Screener Ver. 3.<h4>Analysis Process</h4>Py-Screener Ver. 3 can determine levels of phthalate esters and brominated flame retardants contained in products in accordance with the international analytical standards IEC62321-8 and IEC62321-3-3. It can also test for specific regulated substances (Table 1) under the same conditions and in the same analysis. In this test, background intensity and instrument sensitivity (S/N) were verified before analyzing samples. These parameters are prescribed by IEC62321-8 to ensure the accuracy of the methods used. Background intensity and instrument sensitivity were determined using a reference material (PN: 225-31003- 91) *1 that consisted of a plastic sheet that was spiked with seven phthalate esters. The results met the criteria for both parameters.The testing workflow is shown in Fig. 1. Before testing samples, calibration curves were prepared by analyzing the 1000 mg/kg phthalate ester reference material and polypropylene spiked with brominated flame retardants (ERM-EC591). A hole puncher was used to punch out two discs at a time of the phthalate ester reference material, and a cutter was used to obtain pieces of the other materials. Each material was weighed in a sample cup for analysis. During the analysis of samples, phthalate esters and some of the regulated brominated flame retardants were quantitated using a one-point calibration curve. The remaining brominated flame retardants and specific regulated substances were quantitated using the correction factor database*2 that is included with Py-Screener Ver. 3.<h4>Conclusion</h4>Py-Screener Ver. 3 successfully determined in samples the concentrations of the regulated substances PIP (3:1), UV-328, DP, and SCCPs and MCCPs. Normally, SCCP and MCCP levels are tested using NCI, but Py-Screener Ver. 3 uses EI. This enables it to test for not only SCCPs and MCCPs but also phthalate esters, brominated flame retardants, and other regulated substances in just one analysis. In addition, by using the relative correction factors linked to DEHP in the phthalate ester reference material, the levels of these regulated substances were determined without the need for the corresponding reference materials. Py-Screener Ver. 3 can also create a screening program that addresses substance restrictions under the RoHS Directive, the US TSCA, and the POPs Convention.<h3>4. Thermo Fisher Scientific: Improving low carbon steel production in specialty steel processes</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/prima_pro_process_mass_spectrometer_an1626_7fc840235f.pdf">Full PDF for download</a></li></ul>World crude steel production reached 1,691 million tonnes in 2017, up by 5.3% compared to 2016.1 While much of this capacity is still produced in primary steel processes such as basic oxygen furnaces and electric arc furnaces, the need for refined steel with greater durability and resistance to heat and corrosion has led to the increased use of vacuum degassing processes, such as VOD and RH, in secondary steel production. These processes are able to achieve ultra-low levels of residual carbon, while at the same time retaining desired levels of other alloy materials. If these processes are to achieve the required level of steel product quality, they need fast, continuous gas analysis of the furnace exhaust gas. Without accurate information on the composition of the gas leaving the furnace, any variations in the decarburization process are only detected after the event, resulting in the production of out-of-specification steel.<h4>Advantages of mass spectrometry&nbsp;</h4>Traditional Non-Dispersive Infra-Red (NDIR) analyzers are used in many conventional steelmaking processes to measure CO and CO2 , but they can only sample at atmospheric pressure. In vacuum steelmaking the process pressure changes dramatically, typically from atmospheric pressure down to less than 1 mbar, over the 20-30 minutes of the melt. So NDIR analyzers have to sample some distance downstream from the process. Analytical data is updated several minutes after the gas leaves the melt and the control system is forced to operate on historic rather than real-time data.&nbsp;Paramagnetic analyzers can be used to measure O2 , while thermal conductivity analyzers can be used to measure H2 . These analyzers also suffer from slow response, while the need to operate three different types of analyzers adds to the plant maintenance burden. Moreover, the three analyzers cannot analyze inert gases, so N2 is calculated by difference, a result that suffers from the sum of the errors of the three analytical techniques.&nbsp;Mass spectrometry operates at high vacuum so it is ideal for monitoring vacuum processes. It is also able to monitor all seven components in Table 1 in seconds rather than minutes, ensuring the plant control model is frequently updated with accurate compositional data.<h4>Precision of analysis&nbsp;</h4>At the heart of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=Prima+PRO+Mass+Spectrometer">Thermo Scientific™ Prima PRO Mass Spectrometer</a> (MS) is a magnetic sector analyzer which offers unrivalled precision and accuracy compared with other mass spectrometers. Thermo Fisher Scientific manufactures both quadrupole and magnetic sector mass spectrometers; over thirty years of industrial experience have shown the magnetic sector based analyzer offers the best performance for industrial on-line gas analysis.&nbsp;Key advantages of magnetic sector analyzers include improved precision, accuracy, long intervals between calibrations, and resistance to contamination. Typically, analytical precision is between 2 and 10 times better than a quadrupole analyzer, depending on the gases analyzed and complexity of the mixture.&nbsp;A unique feature of the Prima PRO magnet is that it is laminated. Its analysis times are similar to a quadrupole analyzer, offering the unique combination of rapid analysis and high stability. This allows the rapid and extremely stable analysis of an unlimited number of user-defined gases. The scanning magnetic sector is controlled with 24-bit precision using a magnetic flux measuring device for extremely stable mass alignment.&nbsp;The ion source is an enclosed type for high sensitivity, minimum background interference, and maximum contamination resistance. This is a high-energy (1000 eV) analyzer that offers extremely rugged performance in the presence of gases and vapors that have the potential for contaminating the analyzer. Typical performance specifications for the Prima PRO MS are shown in Table 1. Analytical performance is demonstrated by analyzing the calibration bottle over 1 hour following calibration, with an analysis time of just 6 seconds. Standard deviations measured on the calibration cylinder will be equal to or better than the stated values.

News from LabRulezGCMS Library - Week 07, 2026

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The Multidimensional Chromatography (MDC) Workshop draws experts in this exciting field to share and discuss their research.

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Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in industrial, government and academic laboratories.

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Thermo Scientific™ EA IsoLink™ IRMS System

With the Thermo Scientific™ EA IsoLink™ IRMS Platform, leverage familiar technology and existing expertise for expanded CNSOH isotope analysis, allowing all elemental analysis on a single platform.

<h3>All your elemental analysis on one platform</h3>The EA IsoLink IRMS Platform leverages the existing technological platform of the EA IsoLink IRMS System and FlashSmart EA.<h4>More freedom. More flexibility.</h4>With the Thermo Scientific™ EA IsoLink™ IRMS Platform, you can leverage familiar technology and your staff’s existing know-how for expanded CNSOH isotope analysis, enabling you to perform all your elemental analysis on one technological platform. With different configurations to choose from, your lab can get the capabilities it needs today, with flexibility for the future. Featuring software- driven automation and scalability to grow as you do.<h4>Choose the configuration that’s right for you.</h4>The EA IsoLink IRMS System is an automated, easy-to-use solution for isotopic analysis of carbon, nitrogen, sulfur, oxygen and hydrogen - using bulk samples powered by chromatography-driven technology with high sensitivity on small samples. Available in basic configurations with upgradeability options, this platform offers high throughput and unattended operation, so your lab can get more done in less time.<h4>The EA IsoLink IRMS System features:</h4><ul><li>Thermo Scientific™ Flash™ IRMS EA for sample preparation for IRMS analysis</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2231">Thermo Scientific™ ConFlo IV</a> Universal Interface</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2232">Thermo Scientific™ DELTA™ Q IRMS</a></li></ul><h4>The FlashSmart EA features:</h4><ul><li>Thermo Scientific™ FlashSmart™ EA for weight percentage characterization of CNSHO</li></ul><h3>EA IsoLink CN and CN/OH</h3><ul><li>A powerful solution for C and N, O and H analysis - upgradeable for S analysis</li></ul><h3>EA IsoLink OH</h3><ul><li>Offering dedicated oxygen and hydrogen analysis - with scalability to expand your capabilities to C, N and S</li></ul><h3>EA IsoLink CNSOH</h3><ul><li>A fully automated single system for C, N and S analysis by flash combustion, and O and H analysis by high temperature conversion</li></ul><h4>Connectivity with Thermo Scientific™ IRMS Portfolio</h4>The Flash EA Series connected to the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2232">DELTA Q IRMS</a> provides precise and sensitive measurement of the isotope fingerprints - C, N, S, O and H isotopes - a unique chemical signature of samples. This helps you gain unique insights into food history and origin, as well as environmental pollutants, forensics and geosciences.<figure class="image"><img style="aspect-ratio:650/552;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_EA_Iso_Link_IRMS_System_2_01d3ed421c.jpg" alt="Thermo Scientific™ EA IsoLink™ IRMS System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_EA_Iso_Link_IRMS_System_2_01d3ed421c.jpg 184w," sizes="100vw" width="650" height="552"></figure><h3>More automation. More scalability. All in a single platform.</h3>Delivering proven performance with unprecedented robustness and ease of use, the EA IsoLink IRMS Platform can help your lab drive efficiency, improve cost-effectiveness, and minimize training for new operators.<h4>Low cost per sample for reduced operational costs</h4>Less helium consumption: Helium consumption is reduced by more than 60% for NCS and NC sample analysis, and reduced by more than 30% for OH sample analysis (compared with previous systems).Less replication: Because the EA IsoLink IRMS System measures high and low concentrations in the same sample (wide dynamic range), it reduces the need for replicate analysis (e.g., high carbon and low sulfur, such as in food authenticity or ecology applications).High throughput: Fast analysis provides high sample throughput, resulting in lower cost per sample.<h4>High sensitivity driven by chromatography - even for the smallest sample size</h4>Temperature-ramped GC: Equipped with a temperature-ramped GC feature, the EA IsoLink System gives your lab the highest performance on small sample sizes through optimal baseline separation of analyte gases and sharp peak shapes.Performance synergies: The combination of in-line flash combustion technology and temperature-ramped GC separation significantly improves the performance for all your EA-IRMS applications.<h4>System modularity for future-proof investment</h4>The EA IsoLink IRMS System’s modular design provides the highest flexibility for all applications - enabling you to adapt and scale to new analyses in the future. Through smart upgrade paths, you can easily modify the system to increase performance and productivity as your needs grow over time. Boost your CN system with an S upgrade or add CNS to your OH isotope fingerprints.Thermo Scientific™ MAS Plus Autosampler provides a 125-position helium-purged sample chamber, low blank autosampler for CNS and OH analysis.Thermo Scientific™ AS 1610 Liquid Autosampler offers a versatile solution for injecting liquid samples.Macro reactors enable CNS Analysis of large sample sizes (greater than 60 mg) and higher throughput on standard sample sizes to mg range.<h4>Added flexibility with flash EA series</h4>The flexibility of the Flash EA Series helps you meet growing analytical needs in IRMS and Organic Elemental Analysis (OEA).The FlashSmart Elemental Analyzer for OEA delivers accuracy and precision with internationally recognized certifications. Its straightforward modular design offers a variety of optimized application configurations, including CHN, CHNS, S, N/Protein, CN, CNS, CHNS/O and more. High throughput with 24/7 operation, low cost per sample and optimized helium consumption are all driven by our fully automated dedicated OEA software, Thermo Scientific™ EagerSmart™ Data Handling Software, which can grow with your analytical needs without need for an upgrade.<h4>Smart automation for ease of use</h4>Because of its intelligent software and intuitive design, the EA IsoLink Platform allows operators to leverage familiar technology for higher productivity.Software Platform: <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">The Thermo Scientific™ Qtegra™ Intelligent Scientific Data Solution </a>(ISDS) Software provides seamless control and automation for unattended operation and improved productivity. Regardless of operator skills or the final application, the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Qtegra ISDS Software</a> offers logical, streamlined interface allowing straight forward measurement set-up through analytical Workflows. The software includes auto-stop, standby modes, and other features to minimize intervention. It also allows for integrated data evaluation strategies, customized reports and method development. All of the auto-diagnostics ensure important aspects of the instrument are monitored, maximizing uptime.Thermo Scientific™ smartEA option: This option allows you to focus on your research by combining ease-of-use and unattended analysis to deliver high-precision results. The smartEA option uses the analyzer’s Thermal Conductivity Detector (TCD) trace to define the required sample dilutions in the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2231">ConFlo IV Universal Interface</a>. The straightforward automated workflow allows you to analyze very small amounts, such as nitrogen and sulfur, along with highly abundant elements, such as carbon - all from the same sample.<h3>Addressing a world of applications</h3>For origin and authenticity questions, the EA IsoLink IRMS Platform provides precise and sensitive measurement of the isotope fingerprints - C, N, S, O and H isotopes - a unique chemical signature of samples, helping you gain unique insights into their history and origin.<h4>Food authenticity and origin</h4>Is the label declaration on my food correct?From fruits and vegetables, to wine, honey and coffee, the EA IsoLink IRMS Platform provides isotopic fingerprints ideally suited to determining food integrity.<ul><li>Food adulteration</li><li>Food and beverage origin</li><li>Agronomy</li></ul><h4>Environmental</h4>What is the source of pollution in the soil, water or air?An assessment of individual organic pollutants particles in air contamination (e.g. PM2.5) will be traced with C, N, and S isotope fingerprints.<ul><li>Marine science</li><li>Ecology and biology</li><li>Petroleum and exploration</li></ul><h4>Geosciences</h4>What was the weather like thousands of years ago?By analyzing materials such as sediments, ice cores and speleothems, researchers can understand epochal changes in vegetation, rainfall patterns and temperature.<ul><li>Soil science</li><li>Palaeoclimatology research</li></ul><h4>Forensics</h4>How can we investigate provenance and dietary preferences?From tracing explosives, illegal drugs, counterfeit currency, animal tissues such as ivory, dietary preferences and crime scene evidence, forensic investigations based on isotope fingerprints examine samples’ origin.<ul><li>Archaeology</li><li>Provenance</li></ul><h3>Connectivity for origin and authenticity</h3>Your lab can focus on isotopic investigations by taking advantage of having one partner and one platform for your elemental and isotope analysis. Thanks to the connectivity of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/2232">DELTA Q IRMS</a> and the connecting peripherals that are fully controlled by the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Qtegra ISDS Software</a>, you can also leverage the high throughput, unattended operation and flexibility for demanding analysis, regardless of the applications.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_EA_Iso_Link_IRMS_System_2_dcb8a3d338.jpg" alt="Thermo Scientific™ EA IsoLink™ IRMS System " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_EA_Iso_Link_IRMS_System_2_dcb8a3d338.jpg 245w," sizes="100vw" width="1464" height="933">

Thermo Scientific Triton Series Multicollector Thermal Ionization Mass Spectrometer (TIMS)

High-precision multicollector TIMS for demanding isotope ratio analysis, delivering exceptional sensitivity, stability, and accuracy for ultra-small and low-abundance samples.

The Thermo Scientific™ Triton™ Series Multicollector Thermal Ionization Mass Spectrometer (TIMS) is a high-precision platform designed for the most demanding isotope ratio measurements. Built on more than two decades of continuous development, the Triton Series combines field-proven TIMS performance with state-of-the-art detection and ion-optical technologies to deliver exceptional accuracy, stability, and sensitivity—especially for small samples and low-abundance isotopes.At the heart of the Triton Series is a high-stability thermal ionization source, optimized for maximum ion transmission and minimal kinetic energy spread. This ensures highly reproducible ion beams for both single- and double-filament techniques, enabling precise isotope ratio analysis across a wide range of elements and applications.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Triton_Series_Multicollector_Thermal_Ionization_Mass_Spectrometer_TIMS_2_e9fa5e958e.jpg" alt="Thermo Scientific Triton Series Multicollector Thermal Ionization Mass Spectrometer (TIMS)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Triton_Series_Multicollector_Thermal_Ionization_Mass_Spectrometer_TIMS_2_e9fa5e958e.jpg 182w," sizes="100vw" width="650" height="558"><h3>Advanced detection and ion optics</h3>The Triton Series integrates multiple complementary detector technologies to address diverse analytical challenges:<ul><li>10¹³ Ω Amplifier Technology extends the lower detection limits, delivering faster response times, extremely low noise, and significantly improved internal precision for small ion beams.</li><li>Retarding Potential Quadrupole (RPQ) lenses provide exceptional abundance sensitivity by suppressing scattered ions and mass tailing, enabling accurate quantification of minor isotopes even next to intense ion beams.</li><li>Multi Ion Counting (MIC) packages allow simultaneous detection of the lowest-intensity ion beams using SEM and CDD ion counters, with flexible configurations tailored to nuclear, geochronological, and geochemical applications.</li><li>Stable, linear SEM and CDD ion counters ensure reliable measurements for ultra-low sample amounts and rare isotopes.</li><li>High-performance Faraday cups guarantee uniform response, long operational lifetime, and excellent linearity for high-precision static and dynamic measurements.</li><li>Movable multicollector array supports up to nine Faraday cups with precise alignment over a wide mass range, extendable to static Ca and Li isotope measurements.</li><li>Virtual amplifier technology enables cancellation of gain factor uncertainties through amplifier rotation, achieving low-ppm external reproducibility in efficient static measurement modes.</li></ul><h3>Designed for the most demanding isotope ratio applications</h3>The Triton Series is ideally suited for applications where ultimate precision and high abundance sensitivity are essential, including:<ul><li>Radiogenic and stable isotope geochemistry</li><li>Geochronology (U–Pb, Pb–Pb, Rb–Sr, Sm–Nd, Lu–Hf systems)</li><li>Nuclear safeguards and nuclear forensic isotope analysis</li><li>Environmental and cosmochemical research</li><li>Analysis of ultra-small sample amounts and isotopically scarce materials</li></ul>Available in configurations such as Triton XT and Triton Plus, tailored to different performance priorities within high-precision isotope ratio analysis, the Thermo Scientific Triton Series TIMS offers a flexible, future-proof solution that continues to set the benchmark for thermal ionization mass spectrometry.

Thermo Scientific ConFlo IV Universal Continuous Flow Interface

Universal continuous flow interface for IRMS enabling automated multi-device control, higher throughput, lower costs, and stable, unattended isotope analysis.

Thermo Scientific™ ConFlo IV Universal Continuous Flow Interface is a versatile continuous flow interface designed to significantly expand the application range of stable isotope laboratories using isotope ratio mass spectrometry (IRMS). The ConFlo IV system enables seamless connection of multiple sample preparation devices, delivering fully automated, stable, and highly reproducible measurements.The system features intelligent management of all required reference gases, automatic sample-size recognition, precise matching of sample and reference signals, and advanced self-diagnostics. These capabilities reduce operator involvement, lower operating costs, and increase overall laboratory throughput.<h3>Key features</h3><ul><li>Management of multiple devices Automated switching between different sample preparation units, including activation, deactivation, and reference gas changes, maximizes IRMS utilization.</li><li>Continuous, unattended operation Application switching can occur at any time without operator intervention; preparation devices can be regenerated and reloaded while other analyses are running.</li><li>Maximized performance and efficiency Using reference gases instead of bulk reference materials reduces operating costs by nearly 50 % while increasing sample throughput by almost 50 %.</li><li>Enhanced accuracy and stability Automatic adjustment of reference gas pulse intensities equalizes conditions between sample and reference gases, improving precision and long-term reliability.</li><li>Advanced data quality control Critical system parameters affecting data quality are automatically monitored across all sample sequences.</li><li>Single-interface control All connected preparation and inlet devices are controlled through one interface, with the ability to add new samples or entirely new applications without interrupting ongoing data acquisition.</li></ul>

Thermo Scientific DELTA Q Isotope Ratio Mass Spectrometer

High-performance IRMS combining exceptional sensitivity, robust design, and intuitive Qtegra ISDS software for food authenticity, environmental, forensic, and research isotope applications.

The Thermo Scientific™ DELTA™ Q Isotope Ratio Mass Spectrometer (IRMS) represents a new evolutionary step in isotope ratio analysis, combining outstanding analytical performance with intuitive operation powered by <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Qtegra™ Intelligent Scientific Data Solution (ISDS)</a> software.&nbsp;The DELTA Q IRMS is designed for seamless integration with a wide range of Thermo Scientific peripherals, making it a highly flexible platform for applications such as food authenticity testing, environmental and forensic analysis, doping control, and advanced scientific research.<h4>Outstanding sensitivity</h4><ul><li>Sensitivities of up to 800 molecules per CO₂ ion in dual-inlet mode and 1,000 molecules per ion in continuous-flow mode.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_DELTA_Q_Isotope_Ratio_Mass_Spectrometer_2_671e47510f.jpg" alt="Thermo Scientific DELTA Q Isotope Ratio Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_DELTA_Q_Isotope_Ratio_Mass_Spectrometer_2_671e47510f.jpg 197w," sizes="100vw" width="650" height="517"><h4>Versatility for diverse applications</h4><ul><li>Support for up to 10 collectors in multiple configurations, covering all IRMS applications up to m/z 96.</li><li>Simultaneous mass range up to ±25%, enabling efficient multi-isotope measurements.</li><li>Compatibility with preconcentrators, elemental analyzers, GC interfaces, LC interfaces, and continuous-flow inlets.</li><li>On-line H₂ capability for hydrogen isotope analysis.</li></ul><h4>Highly robust and reliable design</h4><ul><li>A monolithic analyzer with fixed alignment of all ion-optical components, including the electromagnet, ensuring exceptional long-term stability and robustness.</li><li>Integrated signal amplifiers and digitizers minimize external connections and increase reliability.</li><li>Fixed-position ion optics eliminate the need for realignment during installation or routine maintenance.</li><li>Optimized pumping strategy enables single-stage turbo pumping for all standard continuous-flow applications.</li><li>Comprehensive, automated diagnostics driven by Qtegra ISDS software support continuous performance monitoring.</li></ul><h4>Compact and user-friendly design</h4><ul><li>Compact footprint requiring minimal laboratory space.</li><li>Dedicated space for online peripherals on top of the instrument.</li><li>Dual inlet, µ-volume, and multiport interfaces are neatly integrated inside the system.</li><li>Continuous-flow interfaces can be fully controlled from the front panel.</li><li>All pumps are located internally, reducing noise and laboratory clutter.</li></ul><h4>Qtegra™ ISDS Software</h4><ul><li>Significantly increases laboratory productivity with automatic Get Ready functionality, ready-to-use templates, and built-in quality control tools.</li><li>Intelligent, optimized workflows guide users from sample to result while allowing flexible switching between system configurations.</li><li>Ensures full data integrity and traceability for raw data, metadata, and reported results.</li></ul><h4>ACT label certification</h4>The DELTA Q IRMS is certified with the ACT Environmental Impact Label from My Green Lab, providing transparent, third-party verified information on environmental impact across manufacturing, energy and water use, packaging, and end-of-life considerations—supporting sustainable laboratory procurement and reduced carbon footprint.

Products from category IRMS - page 1

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