<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 25th May 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application note by<strong> Shimadzu, </strong>presentation by <strong>MDCW / University of Washington</strong> and poster by <strong>Waters Corporation!</strong></p><h3><strong>1. MDCW / University of Washington: Implementing Tile-Based Fisher Ratio Analysis of GC×GC-TOFMS Data to Obtain a Master Peak Table of All Detected Analyte Compounds in Many Petroleum-Based Samples</strong></h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_9_Halvorsen_136808e314.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>This presentation describes the development of a new chemometric workflow for processing <strong>GC×GC-TOFMS (comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry)</strong> data from petroleum-derived fuels. The work was conducted by researchers from the University of Washington in collaboration with Chevron Technical Center and focuses on creating a comprehensive <strong>Master Peak Table (MPT)</strong> containing all detectable analytes across multiple fuel sample classes. The motivation was that moving from conventional GC to GC×GC dramatically increased chromatographic peak capacity and resolution, but also created a need for more sophisticated data analysis methods capable of handling the much larger number of detected compounds.</p><p>The analytical platform employed <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37"><strong>GC×GC-TOFMS</strong></a> with a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1289"><strong>thermal-flow modulator</strong></a> and a TOF mass spectrometer detector. Fuel samples were analyzed using an <strong>Rxi-1 column (30 m × 0.25 mm × 0.25 μm)</strong> in the first dimension and an <strong>Rxi-17MS column (2.0 m × 0.18 mm × 0.20 μm)</strong> in the second dimension. The sample set included multiple petroleum products such as hydrobates, reformates, naphthas, FCC gasoline, and blank samples. Log-scale chromatograms revealed numerous late-eluting trace compounds and significant compositional differences between fuel batches that were not readily visible in conventional chromatographic representations.</p><p>To process these highly complex datasets, the researchers implemented a <strong>tile-based Fisher Ratio (F-ratio) chemometric approach</strong> using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/348"><strong>ChromaTOF Tile software</strong></a>. The method divides GC×GC chromatograms into small tiles and identifies regions where analyte signals differ significantly between sample classes by comparing between-class and within-class variance. Instead of relying solely on F-ratio ranking, the workflow incorporates statistical testing against blank samples. Three blank chromatograms were used to establish tile-specific confidence intervals and p-test thresholds, allowing the system to determine whether detected signals represent genuine compounds rather than background noise. This strategy enabled the creation of a unified master peak table while minimizing problems caused by retention-time shifts and reducing the need for manual user intervention.</p><p>Application of the method generated <strong>719 statistically significant analyte hits</strong> across the fuel classes and demonstrated excellent reproducibility, with only <strong>6.3% of classifications showing inconsistent behavior among replicates</strong>. Detected compounds included hydrocarbons and aromatic species such as <strong>1-methylnaphthalene, 1,2,4-trimethylbenzene, β-vatirenene, 2-octene, and tetramethylheptadecane</strong>, whose occurrence patterns aligned well with expected fuel chemistry. The resulting master peak table contained both shared and sample-specific compounds and provided a much more comprehensive representation of petroleum composition than conventional workflows. The authors conclude that the approach should be broadly applicable to other complex sample types and could be extended using alternative chemometric metrics beyond Fisher Ratio analysis to address different experimental objectives.</p><h3><strong>2. Shimadzu: A Simple Method for Determination of β-Sitosterol as a Marker of Vegetable Oil Adulteration in Ghee by GC</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_06_sip_gc_042_en_f4c307005b.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>ShimadzuNexis GC-2030 can be effectivelyused for determination of adulteration of Ghee with vegetable oil.</li><li>The NexisGC-2030 easily meets the acceptancecriteria as per the proposed FSSAI method no.01.097:2022.</li><li>This method is suitable for routine food industry analysis and academic research.</li></ul><p>The most common milk product in Indian cuisine is ghee or clarified butter. Due to its high cost, ghee is adulterated with vegetable oil, to gain commercial benefits. β-sitosterol, a common phytosterol, found in a variety of natural sources, including vegetable fat or oil from plants (Figure 1). It is used as a marker of vegetable oil adulteration in ghee<sup>1</sup>.</p><p>The primary goal of this study is to assess the vegetable oil adulteration in ghee by analyzing β-Sitosterol as a marker using gas chromatography (GC). This will establish a foundation for the rapid detection of ghee adulteration. In this study, a simple, sensitive, and inexpensive method is developed for extraction of β-Sitosterol from ghee which is then subjected to gas chromatography with flame ionization detection for quantitation. The effects of several important parameters influencing the extraction efficiencies of β-Sitosterol including water-immiscible organic solvent (type and volume), volume of water, sonication time, surfactant (type and concentration), and organic modifier (type and volume) were investigated. This method is ideal for routine analysis in the food industry during the manufacturing, processing, and commercial testing of milk fat samples, or for academic research purposes.</p><h4><strong>&nbsp;Sample Preparation and Analysis Conditions</strong></h4><p>Standard and sample preparations were conducted following the guidelines outlined in the proposed FSSAI method No. 01.097:20222. The analysis was performed using a Shimadzu <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexis+GC-2030"><strong>Nexis GC-2030</strong></a> equipped with a Flame Ionization Detector (FID), as shown in Figure 2. The specific configuration and analytical conditions used during the study are provided in Table 1.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>A gas chromatography–based method using GC-2030 was developed for the estimation of β-Sitosterol in ghee. The method exhibits a detection limit of 2 %, enabling the identification of vegetable oil adulteration in ghee at levels as low as 2 %. At this adulteration level, the signal of β-Sitosterol achieved a signal-to-noise (S/N) greater than 3, confirming the reliability of detection at the established limit. This method provides a reliable and effective approach for the quantification of β-Sitosterol, which serves as a marker for vegetable oil adulteration in ghee.</p><h3><strong>3. Waters Corporation: Multidimensional Characterization of Short Chain Chlorinated Paraffins (SCCPs) with GC-APCI and Cyclic Ion Mobility</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009386_3232568115.pdf"><strong>Full PDF for download</strong></a></li></ul><p>This poster presents a multidimensional analytical approach for the characterization of <strong>short-chain chlorinated paraffins (SCCPs)</strong>, a class of persistent environmental pollutants included in the Stockholm Convention due to their environmental persistence and bioaccumulation potential. SCCPs are highly complex mixtures of chlorinated hydrocarbons containing thousands of possible congeners, making their analysis particularly challenging. The study evaluates the use of <strong>gas chromatography coupled with atmospheric pressure chemical ionization, cyclic ion mobility spectrometry, and high-resolution mass spectrometry (GC-APCI-IMS-HRMS)</strong> as a powerful platform for improved SCCP characterization.</p><p>The analytical instrumentation consisted of a modified <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890"><strong>Agilent 8890 gas chromatograph</strong></a> equipped with an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=7&amp;search=Rxi-5SilMS"><strong>Rxi-5SilMS capillary column</strong></a><strong> (30 m × 0.25 mm × 0.25 μm)</strong> and connected to a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/202"><strong>Waters SELECT SERIES Cyclic IMS</strong></a><strong> high-resolution mass spectrometer</strong> using an <strong>Atmospheric Pressure GC (APGC) ion source</strong>. Unlike conventional electron ionization methods, APCI was operated in negative-ion mode with a chloroform modifier, promoting the formation of characteristic <strong>[M+Cl]⁻ molecular ions</strong>. This significantly reduced fragmentation and provided strong molecular-ion signals, improving both qualitative identification and quantitative analysis of SCCP homologues.</p><p>Using three commercial SCCP technical mixtures (51.5%, 55%, and 63% chlorine content), the researchers demonstrated that GC-APCI-HRMS could selectively detect SCCP homologues according to carbon-chain length and degree of chlorination. Although substantial chromatographic overlap was observed among many homologues, the addition of <strong>ion mobility spectrometry (IMS)</strong> introduced a valuable extra separation dimension. Distinct drift-time versus m/z trendlines were observed for compounds sharing the same number of chlorine atoms, allowing homologues to be grouped and characterized more effectively than by chromatographic retention and mass spectrometry alone. The IMS data also enabled estimation of the relative abundance of individual homologue groups within each technical mixture.</p><p>The authors further explored the resolving power of the <strong>cyclic IMS device</strong> by employing multiple ion-mobility passes (up to eight cycles) to investigate individual SCCP congeners. While complete separation of individual congeners within a homologue group was not achieved, higher ion-mobility resolution revealed measurable differences between early- and late-eluting species and provided additional insight into compositional differences among SCCP mixtures. The study concludes that combining <strong>GC-APCI, cyclic ion mobility spectrometry, and high-resolution mass spectrometry</strong> offers a powerful multidimensional workflow for the characterization of complex chlorinated paraffin mixtures and may improve environmental monitoring and future regulatory analysis of these challenging contaminants.</p></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 22, 2026

<p><strong>Low analyte recovery is one of the most common challenges encountered during Solid Phase Extraction (SPE) sample preparation. In this Phenomenex Video Tip, Genevie Hodson, Senior Manager of Technical Support and Applications at Phenomenex, explains a practical troubleshooting approach for situations where analyte recovery after an </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=6&amp;manufacturerItems=50"><strong>SPE </strong></a><strong>procedure is lower than expected.</strong></p><p>The key objective of troubleshooting is not simply to identify that recovery is low, but to determine exactly where the analyte was lost during the extraction process. Once the point of loss has been identified, corrective actions can be implemented systematically.</p><h3><strong>Fundamental Principle of SPE Recovery Troubleshooting</strong></h3><h4><strong>Determine Where the Analyte Is Going</strong></h4><p>The most important step when troubleshooting low recovery is to identify the location of the missing analyte.</p><p>The process begins with the assumption that the sample originally contained 100% of the target analyte. If the final recovery is lower than expected, some portion of the analyte has been lost during SPE processing.</p><p>To identify the loss point, each fraction generated during the SPE procedure must be collected and analyzed separately.</p><h5><strong>Fractions to Collect</strong></h5><p>During the SPE workflow, the following fractions should be collected individually:</p><ul><li><strong>Load fraction (flow-through)</strong></li><li><strong>Wash fraction(s)</strong></li><li><strong>Elution fraction</strong></li></ul><p>Each collected fraction is transferred into a vial and analyzed using the laboratory’s analytical method.</p><p><strong>The analytical results reveal whether the analyte is:</strong></p><ul><li>Present in the load fraction</li><li>Present in one of the wash fractions</li><li>Present in the elution fraction</li><li>Missing from all collected fractions</li></ul><p>The location of the analyte provides direct information about the root cause of the recovery problem and guides the next troubleshooting steps.</p><h4><strong>Scenario 1: Analyte Detected in the Load Fraction</strong></h4><h5><strong>What It Means</strong></h5><ul><li>If the analyte appears in the load fraction, it was not retained by the SPE sorbent during sample loading.</li><li>Instead of binding to the stationary phase, the analyte passed directly through the cartridge.</li></ul><h5><strong>Possible Causes</strong></h5><ol><li><strong>Incorrect Phase Selection</strong></li></ol><ul><li>The selected SPE sorbent may not be appropriate for the analyte being extracted.</li><li>If the analyte cannot interact effectively with the sorbent chemistry, retention will not occur.</li></ul><ol start="2"><li><strong>Excessively Strong Sample Solvent</strong></li></ol><ul><li>The sample may be dissolved in a solvent that is too strong.</li><li>A strong sample solvent can prevent proper interaction between the analyte and the sorbent, causing breakthrough during loading.</li></ul><ol start="3"><li><strong>Incorrect pH Conditions</strong></li></ol><ul><li>Retention often depends on maintaining the analyte in the correct ionization state.</li><li>If the sample pH is not appropriate, the analyte may not interact correctly with the sorbent and therefore will not be retained.</li></ul><ol start="4"><li><strong>Sorbent Overload</strong></li></ol><ul><li>The SPE cartridge may have received:<ul><li>Too much analyte</li><li>Too much sample matrix</li></ul></li><li>When sorbent capacity is exceeded, analytes can break through the cartridge and appear in the load fraction.</li></ul><h5><strong>Corrective Action</strong></h5><p>When overload is suspected, increasing the amount of sorbent can improve analyte retention and prevent breakthrough.</p><h4><strong>Scenario 2: Analyte Detected in the Wash Fraction</strong></h4><h5><strong>What It Means</strong></h5><p>If the analyte appears in the wash fraction, it was initially retained but subsequently removed during the washing step.</p><h5><strong>Possible Causes</strong></h5><ol><li><strong>Wash Solvent Too Strong</strong></li></ol><ul><li>The most common cause is an overly aggressive wash solvent.</li><li>A wash solution with excessive elution strength can remove the analyte before the intended elution step.</li></ul><ol start="2"><li><strong>Incorrect pH During Washing</strong></li></ol><ul><li>When pH control is required for retention, the same conditions must be maintained throughout the process.</li><li>A pH change during washing may alter analyte retention and cause premature elution.</li></ul><h5><strong>Corrective Action</strong></h5><p><strong>Review:</strong></p><ul><li>Wash solvent composition</li><li>Wash solvent strength</li><li>pH conditions during washing</li></ul><p>Adjustments should ensure that the analyte remains retained until the elution step.</p><h4><strong>Scenario 3: Analyte Missing from All Fractions</strong></h4><h5><strong>What It Means</strong></h5><ul><li>If the analyte is not found in the load fraction, wash fractions, or elution fraction, it is likely still retained on the SPE sorbent.</li><li>In this situation, the analyte has not been effectively eluted from the cartridge.</li></ul><h5><strong>Possible Cause</strong></h5><p><strong>Elution Solvent Not Strong Enough</strong></p><ul><li>The final elution solvent may lack sufficient strength to remove the analyte from the sorbent.</li><li>As a result, the analyte remains bound to the stationary phase and never reaches the collection vial.</li></ul><h4><strong>Corrective Action</strong></h4><ul><li>Increase the strength of the elution solvent during the final SPE elution step.</li><li>A stronger solvent can improve analyte desorption and recovery.</li></ul><h3><strong>Summary of Low Recovery Troubleshooting Strategy</strong></h3><p>The recommended troubleshooting workflow consists of four steps:</p><h4><strong>1. Collect All SPE Fractions</strong></h4><p><strong>Gather:</strong></p><ul><li>Load fraction</li><li>Wash fraction(s)</li><li>Elution fraction</li></ul><h4><strong>2. Analyze Each Fraction Separately</strong></h4><p>Use the analytical method to determine where the analyte is located.</p><h4><strong>3. Identify the Root Cause</strong></h4><div><div><h5><strong>Analyte Location&nbsp;&nbsp;/&nbsp;&nbsp;Likely Cause</strong></h5><ul><li><strong>Load fraction:</strong> Incorrect phase, strong sample solvent, incorrect pH, sorbent overload</li><li><strong>Wash fraction: </strong>Wash solvent too strong, incorrect pH</li><li><strong>Not found in any fraction:</strong> Incomplete elution from sorbent</li></ul></div></div><h4><strong>4. Apply Corrective Measures</strong></h4><p><strong>Modify:</strong></p><ul><li>Sorbent selection</li><li>Sample solvent composition</li><li>pH conditions</li><li>Sorbent amount</li><li>Wash solvent strength</li><li>Elution solvent strength</li></ul><h3><strong>Other Common SPE Issues</strong></h3><p>In addition to low recovery, several other SPE-related problems are commonly encountered.</p><p><strong>These include:</strong></p><ul><li>Contamination</li><li>Reproducibility Problems</li><li>Flow-Related Issues</li></ul><h3><strong>Conclusion</strong></h3><p>Successful troubleshooting of low SPE recovery depends on identifying where the analyte is lost during the extraction process. Collecting and analyzing individual SPE fractions provides a systematic method for locating the analyte and determining the underlying cause of poor recovery.</p><p>Whether the analyte passes through during loading, elutes during washing, or remains bound to the sorbent after extraction, fraction-based investigation enables targeted corrective actions. This structured approach allows SPE methods to be optimized efficiently and helps restore acceptable analyte recovery.</p>

SPE Troubleshooting: Understanding and Resolving Low Recovery in Solid Phase Extraction

<p><strong>New edition of the Wiley Registry of Mass Spectral Data expands compound coverage to over 915,500 reference spectra, strengthening a foundational layer of Wiley’s scientific data and research intelligence portfolio.</strong></p><p>Wiley, a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation and learning, today released the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/887"><strong>Wiley Registry of Mass Spectral Data 2026</strong></a>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Registry_of_Mass_Spectral_Data_2026_bc408d8245.jpg" alt="Wiley: Registry of Mass Spectral Data 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Registry_of_Mass_Spectral_Data_2026_bc408d8245.jpg 110w," sizes="100vw" width="1527" height="2162"></p><p>As AI-driven research pipelines become standard practice across pharmaceuticals, materials science and forensic investigation, the quality of reference data underpinning those pipelines determines whether results are trusted—or stall at the verification stage.</p><p>The Wiley Registry of Mass Spectral Data 2026 addresses this issue directly: <strong>One of the world’s largest and most trusted mass spectral reference databases</strong> for identifying unknown chemical compounds, it is now expanded and validated to meet the analytical demands of modern, AI-assisted laboratory workflows.</p><p>Laboratories face increasingly complex analytical challenges—from detecting emerging environmental contaminants to identifying novel substances in forensic investigations. As a result, having access to a comprehensive, rigorously validated spectral database has become foundational to getting results right. It is also a critical validation layer for AI-driven workflows.</p><p>The Wiley Registry database helps scientists and researchers around the world with <strong>environmental testing, forensic investigation, food safety research, drug analysis, defense research, homeland security</strong>, and more, providing critical reference data for identifying and analyzing chemical compounds and materials.</p><p>The new edition represents a significant expansion of the collection, which now contains <strong>more than 915,500 reference spectra</strong>—the unique chemical “signatures” used to identify substances—making it among the most comprehensive databases of its kind. <strong>More than 42,000 new GC-MS spectra</strong> representing <strong>34,100 compounds </strong>have been added, with data from laboratories, world patents and peer-reviewed scientific literature. Each spectrum is validated to the same rigorous standard, ensuring that the data perform reliably whether a researcher is running a manual comparison or feeding it into an automated identification pipeline.</p><p>The Wiley Registry is part of Wiley’s growing portfolio of scientific data and research intelligence solutions, which includes spectral databases, chemistry and materials literature, and analytical tools designed to support researchers and organizations from discovery through to applied outcomes. Wiley spectral database solutions are trusted by the world’s top pharmaceutical companies and many Fortune 500 organizations—reflecting Wiley’s mission to transform knowledge into actionable intelligence, equipping researchers with the rigorous reference data that drives real-world scientific discovery.</p><p><strong>Updated every three years,</strong> the Wiley Registry is among the company’s longest-standing data products, with a history spanning decades of continuous development.</p><p>“<i>The Wiley Registry is a foundational layer of intelligence for any laboratory conducting GC-MS analysis—and increasingly, for the AI-assisted workflows being built around that analysis</i>,” said Armughan Rafat, Wiley senior vice president and chief AI &amp; data analytics officer. “<i>By expanding compound coverage and applying consistent quality measures across the collection, we help analysts provide a deterministic layer to move from unknown to identified faster.</i>”</p><p>Available in the most common instrumentation manufacturer formats, the Wiley Registry of Mass Spectral Data 2026 also offers bundled options to access even more data with its <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/885"><strong>Wiley Registry/NIST</strong></a> and the <strong>KnowItAll GC-MS Library collection</strong> for labs seeking the most comprehensive coverage and workflow integration. The Wiley Registry is also available as a KnowItAll subscription for continued access to new data as they are added to the collection.</p><p>Spectral databases contain detailed “<strong>fingerprints</strong>” of substances captured through analytical techniques such as <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/934"><strong>mass spectrometry (MS)</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1271"><strong>Raman spectroscopy</strong></a>, enabling researchers to identify unknown materials by comparing their spectral signatures against validated reference spectra. This data is essential for quality control, research verification and discovery across industries from pharmaceuticals to materials science.</p><blockquote><p>For more information about the Wiley Registry of Mass Spectral Data 2026, please <a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/solutions/technique/gc-ms/wiley-registry-of-mass-spectral-data/"><strong>visit this website</strong></a>.</p></blockquote><h4><strong>About Wiley</strong></h4><p>Wiley (NYSE: WLY) is a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation, and learning. With more than 200 years at the center of the scholarly ecosystem, Wiley combines trusted publishing heritage with AI-powered platforms to transform how knowledge is discovered, accessed, and applied. From individual researchers and students to Fortune 500 R&amp;D teams, Wiley enables the transformation of scientific breakthroughs into real-world impact. From knowledge to impact—Wiley is redefining what's possible in science and learning. Visit us at Wiley.com.</p>

Wiley releases the 2026 edition of the Wiley Registry of Mass Spectral Data to expand GC-MS identification intelligence

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Thermo Scientific ITEX Dynamic Headspace Tool 

Thermo Scientific ITEX Dynamic Headspace Tool enables automated VOC enrichment with ppt sensitivity using dynamic headspace for GC workflows.

<p><strong>The Thermo Scientific™ ITEX Dynamic Headspace Tool is an autosampler accessory for the</strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/63"><strong> TriPlus™ RSH </strong></a><strong>and </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/422"><strong>TriPlus RSH SMART</strong></a><strong> Autosamplers designed for the enrichment of volatile organic compounds (VOCs) using dynamic headspace technology. It enables ppt-level sensitivity and allows sample enrichment to be easily integrated into an automated gas chromatography (GC) workflow.</strong></p><ul><li>The ITEX-DHS technique uses a gas-tight syringe to collect the headspace and a microtrap inside the syringe needle to efficiently trap and concentrate VOCs through repeated syringe strokes.&nbsp;</li><li>Sensitivity can be scaled according to the number of strokes, making the method suitable for both low- and high-concentration samples.&nbsp;</li><li>The system is designed for easy method set-up with only a few parameters, simple access to the trap, and excellent robustness for long-term operation.&nbsp;</li><li>A closed system removes any risk of breakthrough.&nbsp;</li><li>Independent trap desorption temperature and flow control maximize desorption efficiency without affecting GC inlet settings.&nbsp;</li><li>When used with the TriPlus RSH SMART autosampler, the SMART gas-tight syringe enables automatic usage traceability.&nbsp;</li><li>The entire automated workflow can be fully controlled through <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/76"><strong>Thermo Scientific™ Chromeleon™ CDS</strong></a>.</li></ul><p>For VOC analysis in many liquid and solid samples, ITEX offers a valuable alternative to classical enrichment techniques by combining ease of use with robust performance.</p><h3><strong>Key features</strong></h3><ul><li>Dynamic headspace VOC enrichment with<strong> ppt-level sensitivity</strong></li><li><strong>Easy integration</strong> into automated GC workflows</li><li><strong>Gas-tight syringe and microtrap</strong> in the needle for efficient analyte concentration</li><li><strong>Scalable sensitivity</strong> based on the number of syringe strokes</li><li><strong>Easy method set-up</strong> with few parameters</li><li><strong>Robust design </strong>for long-term operation</li><li><strong>Closed system</strong> minimizing the risk of breakthrough</li><li><strong>Independent desorption</strong> temperature and flow control</li><li><strong>Automatic usage</strong> traceability with SMART gas-tight syringe</li><li>Full control through <strong>Chromeleon CDS</strong></li></ul><h3><strong>Technical specifications</strong></h3><ul><li><strong>Description: </strong>includes SMART gas-tight syringe, focusing trap, built-in trap heating, cooling fan, and trap cleaning capability</li><li><strong>Application: </strong>enrichment of volatile organic compounds (VOCs)</li><li><strong>Compatible equipment: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/63"><strong>TriPlus RSH</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/422"><strong>TriPlus RSH SMART </strong></a>Autosamplers</li><li><strong>Type:</strong> autosampler accessory</li><li><strong>Unit size: </strong>each</li></ul>

Thermo Scientific TriPlus™ RSH SMART Autosampler

Extend automation, performance, and versatility for GC and GC/MS applications, while ensuring easier and safer operations through SMART consumables ID recognition and usage tracking.

<div><div id="product-description"><p><strong>Expand automated sampling capabilities beyond liquid, headspace, and solid phase microextraction (SPME) injections. The advanced, built-in robotics of the Thermo Scientific™ TriPlus™ RSH SMART Autosampler deliver exceptional precision, sample handling flexibility, and reliable unattended operation. Enabling SMART consumables tracking, it offers easier, safer and traceable operations. Accurate and repeatable sample preparation and injection are essential to achieving the highest quality GC/GC-MS results. Enhance data quality and laboratory efficiency by automating your entire sample handling workflow.</strong></p></div><div><p>The TriPlus RSH SMART Autosampler brings together technological innovations that further expand automation, performance and versatility for GC and GC-MS applications, while ensuring easier and safer operations through SMART consumables ID recognition and usage tracking. Automated high-precision sample handling eliminates the manual labor and downtime typically required for tasks as standard/sample dilutions, internal standard addition and derivatization.</p><h3><strong>SMART Consumables</strong></h3><p>Validated SMART consumables are equipped with unique SMART chip storing parameters, ranges and usage history; enabling full traceability of sample preparation down to the syringe.</p><h3><strong>Automatic Syringe Changeout</strong></h3><p>Automatic Tool Change (ATC) capability automates the use of different syringes for sample preparation steps or different injection techniques within the sequence.</p><h3><strong>Vial Bottom Sensing Expands Application Range</strong></h3><p>Precise detection of vial bottoms enables the autosampler to accurately withdraw from sample amounts as little as 5 μL, enhancing data quality of sample-limited applications.</p><h3><strong>Flexible liquid sample handling</strong></h3><p>Optimized liquid injection modes and customizable syringe filling techniques, support a wide range of sample types and full GC inlet compatibility.</p><h3><strong>Automated headspace injection for volatile analysis</strong></h3><p>High temperature gas-tight syringe allows direct headspace injection into the GC inlet for increased injection volume flexibility. Sample vial capacity of up to 300x 10 mL/20 mL vials and sample incubation overlapping, facilitate long unattended operation.</p><h3><strong>Automated, solvent-free SPME</strong></h3><p>Precise control of all steps—fiber preconditioning, adsorption and desorption, as well as fiber washes—delivers maximum performance for SPME applications. Boost productivity with the optimized SPME Arrow design. It offers optimized fiber geometry to achieve 10x superior sensitivity compared to classical SPME, 2x faster extraction time and superior robustness.</p><h3><strong>Automated Sample Preparation</strong></h3><p>The Triplus RSH SMART Autosampler combines highly versatile sample injection capability with automated sample preparation procedures, eliminating typical GC-MS workflow bottlenecks. Daily operations ranging from sample/standard dilution to more complex derivatization protocols, can be fully automated and easily programmed with the Sampling Workflow Editor Software.</p><h3><strong>Extend productivity with the optional 1D barcode reader</strong></h3><p>The optional 1D barcode reader eliminates the need to log and track sample information manually; enabling you to streamline internal operations, save time, increase efficiency, and reduce errors.</p><h3><strong>Specifications</strong></h3><ul><li><strong>Type: </strong>TriPlus RSH SMART Standard Liquid, Regular Rail</li><li><strong>Sample Capacity:</strong> 4608 Well Plates, 840 x 0.5 mL or 0.7 mL Vials, 648 x 2 mL Sample Vials, 240 x 10 mL or 20 mL Vials</li><li><strong>Injection Mode: </strong>8 Fully Customizable Method-Specific Injection Mode Presets</li><li><strong>Injection Speed:</strong> Selectable from 0.1 μL/s to 2000 μL/s</li><li><strong>Injection Volume: </strong>0.1 to 10,000 μL</li><li><strong>Description: </strong>TriPlus RSH SMART configured for liquid injection on regular X-axis length. Only for manual tool change. Complete with liquid syringe tool, 2 x 10 μL SMART syringes, standard washing station and a single tray holder with 3 trays for 2 mL vials. Expandible to other sampling techniques (Headspace, SPME, SPME Arrow, ITEX-DHS) and with sample preparation tools.</li><li><strong>Tool Exchange:</strong> Only for manual tool exchange. No tool park station.</li><li><strong>For Use With (Equipment):</strong> Compatible with Smart syringes/fibers only.</li></ul></div></div>

Thermo Scientific™ TriPlus™ RSH Autosampler

Robotic GC autosampler with multimode injection, tool exchange, and full sample prep automation. Enables 24/7 workflows for food, environmental, and forensic labs.

<h4><strong>Flexible, high-capacity autosampler for GC and GC-MS with advanced sample prep automation</strong></h4><p><strong>The TriPlus RSH Autosampler is a versatile robotic sampling platform designed to maximize automation, precision, and productivity in gas chromatography workflows. Fully compatible with Thermo Scientific™ GC and GC-MS systems, it supports liquid, headspace (HS), and SPME/SPME Arrow injections, with optional modules for µSPE, ITEX-DHS, and automated sample preparation. The unique Automatic Tool Change (ATC) system allows the autosampler to switch between up to six syringes in a single sequence, enabling unattended workflows for complex multistep protocols.</strong></p><h3><strong>Key Features and Benefits</strong></h3><h4>🧪 <strong>Multimode Injection and Sample Handling</strong></h4><ul><li>Supports liquid, headspace, SPME, SPME Arrow, and ITEX-DHS techniques</li><li>Switch between injection modes in a single sequence using ATC</li><li>Bottom vial sensing enables precise injections from as little as <strong>5 μL</strong> of sample</li></ul><h4>🔁 <strong>Automated Sample Preparation</strong></h4><ul><li>Perform dilution, standard addition, derivatization, and internal standard workflows</li><li>Tools: Vortexer, Incubator, Heatex-Stirrer, Dilutor, µSPE module</li><li>Visual drag-and-drop <strong>Sampling Workflow Editor</strong> for custom prep protocols</li></ul><h4>📦 <strong>High Throughput and Capacity</strong></h4><ul><li>Unattended operation with up to <strong>972 × 2 mL vials</strong> or <strong>840 × 0.7 mL vials</strong></li><li>Extended X-arm option for larger trays and accessory support</li><li>Dual-GC configurations with Clone Mode or DoublePro setups</li></ul><h4>⚙️ <strong>Precision and Flexibility</strong></h4><ul><li>Automated Tool Change (ATC): Up to <strong>6 tools</strong> in one sequence</li><li>Injection volume range: <strong>0.1 μL to 10 mL</strong></li><li>Compatible with all major GC injector types (SSL, PTV, OC, PKD, PPKD)</li></ul><h4>🧠 <strong>Smart Software and Control</strong></h4><ul><li>Fully integrated with <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/76"><strong>Chromeleon™</strong></a>,<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758"><strong> Xcalibur™</strong></a>, and <strong>Chrom-Card™ CDS</strong></li><li>Local controller or virtual terminal control interface</li><li>Barcode readers for full sample tracking</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/application::product.product/Thermo-TriPlus-RSH-Autosampler-1.jpg" alt="Thermo Scientific™ TriPlus™ RSH Autosampler" width="null" height="null"></p><h3><strong>Applications</strong></h3><ul><li><strong>Food safety</strong>: Trace analytes, contaminants, derivatization (e.g. FAMEs, dioxins)</li><li><strong>Environmental</strong>: VOCs, SVOCs, POPs, air toxics</li><li><strong>Forensics &amp; clinical</strong>: Biological matrices, explosive residues, drugs</li><li><strong>Chemical industry</strong>: Routine QC, trace impurities, residual solvents</li><li><strong>High-throughput labs</strong>: 24/7 unattended workflows with complex prep steps</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/application::product.product/QExactive-GCMSMS-Orbitrap-with-Autosampler-sideangle-1856x1391.jpg-650.jpg" alt="Thermo Scientific™ TriPlus™ RSH Autosampler" width="null" height="null"></p>

Thermo Scientific™ TriPlus™ 500 GC Headspace Autosampler

Powered by a completely new design, the Thermo Scientific™ TriPlus™ 500 Headspace Autosampler delivers reliability and robustness for testing laboratories performing volatiles analysis.

<p><strong>Powered by a completely new design, the Thermo Scientific™ TriPlus™ 500 Headspace Autosampler delivers reliability and robustness for testing laboratories performing volatiles analysis.</strong></p><p>Valve-and-loop technology and <strong>other innovative features</strong> ensure that this autosampler streamlines daily workflows, saving time with reliable unattended operation, optimizing sample throughput with expanded vial capability, and facilitating method portability with powerful software. Smartly integrated with the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/483"><strong>Thermo Scientific™ TRACE™ 1600 Series GC</strong></a><strong>,</strong> this modular platform provides today's analytical testing and services laboratories with the productivity needed to succeed.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Schematicke_znazorneni_nastriku_pomoci_Head_Space_autosampleru_Thermo_Tri_Plus_500_fd64009b8a/Pragolab-Schematicke-znazorneni-nastriku-pomoci-HeadSpace-autosampleru-Thermo-TriPlus-500.jpg" alt="Thermo Scientific™ TriPlus™ 500 GC Headspace Autosampler: Valve-and-loop headspace injection principle" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Schematicke_znazorneni_nastriku_pomoci_Head_Space_autosampleru_Thermo_Tri_Plus_500_fd64009b8a/thumbnail_Pragolab-Schematicke-znazorneni-nastriku-pomoci-HeadSpace-autosampleru-Thermo-TriPlus-500.jpg 245w," sizes="100vw" width="1812" height="560"></p><h4><strong>Reliability for analytical testing and services laboratories and versatility for research and method development.</strong></h4><p>The new design of the TriPlus 500 Headspace Autosampler incorporates innovative features for highly accurate analytical results, including:</p><h5><strong>New pneumatic controls for high precision and robustness</strong></h5><ul><li><strong>Best injection repeatability</strong> for consistent results at every run.</li><li><strong>No carryover </strong>due to effective sample path purging.</li><li><strong>Automatic leak check </strong>during injection to ensure safe runs.</li></ul><figure class="image"><img style="aspect-ratio:681/480;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Tri_Plus_500_GC_Headspace_Autosampler_2_62a58c525f.jpg" alt="Thermo Scientific™ TriPlus™ 500 GC Headspace Autosampler: Long Sequence Area Counts Repeatability. 120 consecutive headspace injections of a 50 ppm ethanol solution in water (5 ml in 10 ml crimp top vial). Overall RSD%=0.7" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Tri_Plus_500_GC_Headspace_Autosampler_2_62a58c525f.jpg 221w," sizes="100vw" width="681" height="480"></figure><h5><strong>Best sample integrity and ease-of-use via direct column connection</strong></h5><ul><li><strong>A shorter sample path</strong> for high inertness towards polar compounds.</li><li><strong>Expanded high temperature</strong> <strong>applicability</strong> <strong>with higher recovery </strong>of high boiling point compounds.</li><li><strong>Simplified method set up </strong>with no transfer line and injector temperature settings required.</li></ul><figure class="image"><img style="aspect-ratio:720/484;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Tri_Plus_500_GC_Headspace_Autosampler_3_a7e8932898.jpg" alt="Thermo Scientific™ TriPlus™ 500 GC Headspace Autosampler: Recovery of a standard hydrocarbon mixture C10-C40 at high temperature operation, showing >60% recovery at 300°C" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Tri_Plus_500_GC_Headspace_Autosampler_3_a7e8932898.jpg 232w," sizes="100vw" width="720" height="484"></figure><h5><strong>Compact yet scalable design for better laboratory efficiency and productivity</strong></h5><ul><li>Compact HS-GC design saves<strong> 30%</strong> of valuable bench space.</li><li>Tailored throughput requirements with in-field scalability from<strong> 12 to 240 vials</strong>, requiring no additional space and no compromise on performance.</li><li>Faster sample equilibration with the new <strong>Quick Spin Shaking design</strong> for maximal sensitivity in a shorter cycle time.</li></ul><h5><strong>Comprehensive HS-GC configuration solution</strong></h5><ul><li>Available with<strong> direct column connection</strong> or transfer line for maximum configuration flexibility.</li><li>When a direct column connection is not possible, the autosampler configured with a transfer line maintains <strong>high precision, efficient sample transfer.</strong></li><li>When configured with a transfer line, the TriPlus 500 HS autosampler<strong> </strong>is ideal for connecting to the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/483"><strong>Thermo Scientific™ TRACE™ 1600 Series GC</strong> </a>with auxiliary oven or for connection to third-party GC instruments</li><li>The TriPlus 500 HS with transfer line allows <strong>combined headspace and liquid injection</strong> in the same column, through operation with the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/70"><strong>TriPlus 100 LS </strong></a><strong>or TriPlus RSH or</strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/422"><strong> RSH SMART</strong></a><strong> autosampler on the same GC.</strong></li></ul><h5><strong>Software and system checks for compliance and data integrity</strong></h5><ul><li>Integrated with <strong>Thermo Scientific™ Chromeleon™ CDS software</strong>, Title 21 CFR Part 11-compliant.</li><li>Easy analytical system performance qualification with the IQ/OQ/PQ Qualification Wizard and daily sequence performance checks with the System Suitability Test Wizard.</li></ul><h4><strong data-start="0" data-end="18" data-is-only-node="">Specifications</strong></h4><ul><li><strong data-start="21" data-end="30">Type:</strong> TriPlus™ 500 GC Headspace Autosampler</li><li><strong data-start="71" data-end="91">Sample Capacity:</strong> 12 Vials, Upgradable to 120 and 240 Vials</li><li><strong data-start="136" data-end="155">Injection Mode:</strong>&nbsp;<ul><li>Standard</li><li>Multiple Headspace Extraction (MHE)</li><li>Multiple Headspace Injection (MHI)</li></ul></li><li><strong data-start="240" data-end="256">Description:</strong> TriPlus™ 500 Headspace Autosampler with Direct Column Connection</li><li><strong data-start="324" data-end="337">Software:</strong> Thermo Scientific™ Chromeleon CDS, Thermo Scientific™ TraceFinder, and Thermo Scientific™ XCalibur Software</li><li><strong data-start="448" data-end="477">For Use With (Equipment):</strong> <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/483">Trace 1600 Series</a></li><li><strong data-start="498" data-end="511">Quantity:</strong> Each</li><li><strong data-start="519" data-end="533">Unit Size:</strong> Each</li></ul>

Products from category HeadSpace and SPME injection from Thermo Fisher Scientific - page 1

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